Alessandra Sottini, Virginia Quaresima, Mosè Barbaro, Lucia Moiola, Massimo Filippi, Maria Malentacchi, Marco Capobianco, Marco Puthenparampil, Paolo Gallo, Eleonora Cocco, Jessica Frau, Mauro Zaffaroni, Clara Guaschino, Chiara Stampatori, Chiara Mancinelli, Laura Brambilla, Valentina Torri Clerici, Marika Vianello, Francesca Vitetta, Diana Ferraro, Pamela Rosettani, Maura Chiara Danni, Marta Conti, Maria Grimoldi, Ruggero Capra, Luisa Imberti
Thymic and bone marrow outputs were evaluated in 13 sequential samples of 68 multiple sclerosis patients who initiated alemtuzumab and were clinically followed for 48 months. Three months after alemtuzumab infusions, the levels of new T lymphocytes were significantly reduced, but progressively increased reaching the highest values at 36 months, indicating the remarkable capacity of thymic function recovery. Newly produced B cells exceeded baseline levels as early as 3 months after alemtuzumab initiation...
September 15, 2023: Journal of Neuroimmunology