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JOURNAL ARTICLE
Veronica Yu, Sule Yilmaz, Jorie Freitag, Kah Poh Loh, Lee Kehoe, Grace Digiovanni, Jessica Bauer, Chandrika Sanapala, Ronald M Epstein, Reza Yousefi-Nooraie, Supriya Mohile
OBJECTIVES: Explore how older patients utilize their social networks to inform prognostic understanding. METHODS: In a pilot study of adults (≥65 years old) with advanced cancer, 16 patients completed surveys, social network maps, and semi-structured interviews exploring with whom they preferred to communicate about their illness. Interviews were analyzed using open-coding, and codes were categorized into emergent themes. Social network maps and themes were analyzed via mixed-methods social network analysis (MMSNA)...
October 15, 2022: Patient Education and Counseling
#22
JOURNAL ARTICLE
Izzy Gainsburg, Veronica Derricks, Cleveland Shields, Kevin Fiscella, Ronald Epstein, Veronica Yu, Jennifer Griggs
Disparities between Black and White Americans persist in medical treatment and health outcomes. One reason is that physicians sometimes hold implicit racial biases that favor White (over Black) patients. Thus, disrupting the effects of physicians' implicit bias is one route to promoting equitable health outcomes. In the present research, we tested a potential mechanism to short-circuit the effects of doctors' implicit bias: patient activation, i.e., having patients ask questions and advocate for themselves...
August 9, 2022: Proceedings of the National Academy of Sciences of the United States of America
#23
JOURNAL ARTICLE
Avalene W K Tan, Ronald H L Li, Yu Ueda, Joshua A Stern, Mehrab Hussain, Satoshi Haginoya, Ashely N Sharpe, Catherine T Gunther-Harrington, Steven E Epstein, Nghi Nguyen
Wildfires pose a major health risk for humans, wildlife, and domestic animals. We previously discovered pathophysiologic parallels between domestic cats with naturally occurring smoke inhalation and thermal burn injuries and human beings with similar injuries; these were characterized by transient myocardial thickening, cardiac troponin I elevation and formation of intracardiac thrombosis. While the underlying mechanisms remain unclear, results from murine models suggest that platelet priming and activation may contribute to a global hypercoagulable state and thrombosis...
2022: Frontiers in Veterinary Science
#24
JOURNAL ARTICLE
Lee Kehoe, Chandrika Sanapala, Grace DiGiovanni, Reza Yousefi-Nooraie, Sule Yilmaz, Jessica Bauer, Kah Poh Loh, Sally Norton, Paul Duberstein, Charles Kamen, Nikesha Gilmore, Abdi Gudina, Amber Kleckner, Supriya Mohile, Ronald M Epstein
BACKGROUND: Little is known about how older adults (OA) with advanced cancer interact with social network members (NM), and the nature of communication. This qualitative study aimed to characterize the processes by which OAs with cancer engage with NMs regarding their illness. METHODS: OAs 65 + with advanced cancer and considering treatment (n = 29) and NMs (n = 18) underwent semi-structured interviews asking 1) about their illness understanding; 2) to identify NMs with whom OAs discuss health-related matters; and 3) to describe the content, process, and impact of those illness-related conversations...
October 2022: Patient Education and Counseling
#25
REVIEW
Savanah D Gisriel, Ji Yuan, Ryan C Braunberger, Danielle L V Maracaja, Xueyan Chen, Xiaojun Wu, Jenna McCracken, Mingyi Chen, Yi Xie, Laura E Brown, Peng Li, Yi Zhou, Tarsheen Sethi, Austin McHenry, Ronald G Hauser, Nathan Paulson, Haiming Tang, Eric D Hsi, Endi Wang, Qian-Yun Zhang, Ken H Young, Mina L Xu, Zenggang Pan
Rare cases of human herpesvirus 8 (HHV8)-negative effusion-based large B-cell lymphoma (EB-LBCL) occur in body cavities without antecedent or concurrent solid mass formation. In contrast to HHV8 + primary effusion lymphoma (PEL), EB-LBCL has no known association with HIV or HHV8 infection. However, the small sample sizes of case reports and series worldwide, especially from non-Japanese regions, have precluded diagnostic uniformity. Therefore, we conducted a retrospective, multi-institutional study of 55 cases of EB-LBCL and performed a comprehensive review of an additional 147 cases from the literature to identify distinct clinicopathologic characteristics...
October 2022: Modern Pathology
#26
JOURNAL ARTICLE
Khadar Abdi, Ramy Abramsky, Nickie Andescavage, Jephté Bambi, Sudeepta Basu, Cynthia Bearer, Eric J Benner, Thérèse Biselele, Nikolay Bliznyuk, Jeroen Breckpot, Galen Carey, Agnes Chao, Line Iadsatian Christiansen, Silvia Comani, Pierpaolo Croce, Maarten De Vos, Anneleen Dereymaeker, Laura Dubois, Amelia J Eisch, Adrian Epstein, Neta Geva, Yael Geva, Marc Gewillig, Sheyenne Gillis, Ronald N Goldberg, Magnus Gram, Simon Gregory, Danielle Guez-Barber, Masahiro Hayakawa, Nicole Lind Henriksen, Tim Hermans, Reli Hershkovitz, Kristine Holgersen, Bo Holmqvist, Vaibhav Jain, Katrien Jansen, Vinay Kandula, Kushal Kapse, Masahiro Kawaguchi, Abdulhafeez Khair, Mohammad Khazaei, Hiroyuki Kidokoro, Frederico C Kiffer, Katherine Kisilewicz, Sumire Kumai, Helene Lacaille, David Ley, Catherine Limperopoulos, Sandy Ebba Hallengreen Lindholm, Prosper Lukusa, Rebecca Lundberg, Peter MacFarlane, Pavle Matak, Laetitia Mavinga, Catherine Mayer, Gloire Mbayabo, Takamasa Mitsumatsu, Gerrye Mubungu, Jonathan Murnick, Tomohiko Nakata, Hajime Narita, Parvathi Nataraj, Jun Natsume, Gunnar Naulaers, Rahul Nikam, Niklas Ortenlöf, Katherine Ottolini, Xiaoyu Pan, Kelly Pegram, Anna A Penn, Subechhya Pradhan, Khadijeh Raeisi, Nicholas Rickman, Blaire Rikard, Reut Rotem, Per Torp Sangild, Yoshiaki Sato, Fumi Sawamura, Eilon Shany, Ilan Shelef, Anna Shiraki, Laura Smets, Livia Sura, Ryosuke Suzui, Takeshi Suzuki, Bruno-Paul Tady, Gentaro Taga, Gabriella Tamburro, Liesbeth Thewissen, J Will Thompson, Thomas Thymann, Cansu Tokat, Claire-Marie Vacher, Cyndi Valdes, Suvi Vallius, Sergei Vatolin, Hama Watanabe, Adi Yehuda Weintraub, Michael Weiss, Hiroyuki Yamamoto, Salem Shimrit Yaniv, Noelle Younge, Sanghee Yun, Filippo Zappasodi
No abstract text is available yet for this article.
2022: Journal of Neonatal-perinatal Medicine
#27
JOURNAL ARTICLE
Zahidah I Zeid, Tom Hughes, Mei-Ho Lee, Jimmy Lee, Reza Tarmizi, Fernandes Opook, Alexter Japrin, Mohamed S M Azian, Muhammad Y Wazlan, Nor A Aziz, Ronald H M Tinggu, Emilly Sion, Siew T Wong, Jum R A Sukor, Jonathan H Epstein, Peter Daszak
The Bornean sun bear ( Helarctos malayanus euryspilus ) is the smallest subspecies of sun bear. Their numbers are declining, and more research is needed to better understand their health and biology. Forty-four bears housed at the Bornean Sun Bear Conservation Centre (BSBCC) in Sabah, Malaysia, were screened for known and novel viruses in November 2018. Ursid γ-herpesvirus type 1 (UrHV-1) is a herpesvirus that has been detected from swab samples of clinically healthy sun bears and biopsy samples of oral squamous cell carcinoma in sun bears...
March 2022: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
#28
JOURNAL ARTICLE
Electronic bridge to mental health for college students: A randomized controlled intervention trial.
Cheryl A King, Daniel Eisenberg, Jacqueline Pistorello, William Coryell, Ronald C Albucher, Todd Favorite, Adam Horwitz, Erin E Bonar, Daniel Epstein, Kai Zheng
OBJECTIVE: Suicide is the second leading cause of death among college students in the United States, and the percentage of students reporting suicidal thoughts is increasing. Nevertheless, many students at risk do not seek mental health (MH) services. This randomized controlled trial (RCT) examined the efficacy of Electronic Bridge to Mental Health for College Students (eBridge) for increasing at-risk students' linkage to MH services. METHOD: Students from four universities were recruited via email; 40,347 (22...
January 31, 2022: Journal of Consulting and Clinical Psychology
#29
JOURNAL ARTICLE
Michael Hoerger, Robert Gramling, Ronald Epstein, Joshua J Fenton, Supriya G Mohile, Richard L Kravitz, Brenna Mossman, Holly G Prigerson, Sarah Alonzi, Kirti Malhotra, Paul Duberstein
BACKGROUND: Informed treatment decision-making necessitates accurate prognostication, including predictions about quality of life. AIMS: We examined whether oncologists, patients with advanced cancer, and caregivers accurately predict patients' future quality of life and whether these predictions are prospectively associated with end-of-life care and bereavement. MATERIALS & METHODS: We conducted secondary analyses of clinical trial data...
June 2022: Psycho-oncology
#30
JOURNAL ARTICLE
Jaffer Okiring, Isobel Routledge, Adrienne Epstein, Jane F Namuganga, Emmanuel V Kamya, Gloria Odei Obeng-Amoako, Catherine Maiteki Sebuguzi, Damian Rutazaana, Joan N Kalyango, Moses R Kamya, Grant Dorsey, Ronald Wesonga, Steven M Kiwuwa, Joaniter I Nankabirwa
BACKGROUND: Environmental factors such as temperature, rainfall, and vegetation cover play a critical role in malaria transmission. However, quantifying the relationships between environmental factors and measures of disease burden relevant for public health can be complex as effects are often non-linear and subject to temporal lags between when changes in environmental factors lead to changes in malaria incidence. The study investigated the effect of environmental covariates on malaria incidence in high transmission settings of Uganda...
October 30, 2021: BMC Public Health
#31
JOURNAL ARTICLE
Kevin Fiscella, Ronald M Epstein, Jennifer J Griggs, Mary M Marshall, Cleveland G Shields
RATIONALE: Implicit racial bias affects many human interactions including patient-physician encounters. Its impact, however, varies between studies. We assessed the effects of physician implicit, racial bias on their management of cancer-related pain using a randomized field experiment. METHODS: We conducted an analysis of a randomized field experiment between 2012 and 2016 with 96 primary care physicians and oncologists using unannounced, Black and White standardized patients (SPs)who reported uncontrolled bone pain from metastatic lung cancer...
2021: PloS One
#32
REVIEW
Samuel B Harvey, Ronald M Epstein, Nicholas Glozier, Katherine Petrie, Jessica Strudwick, Aimee Gayed, Kimberlie Dean, Max Henderson
The COVID-19 pandemic has heightened interest in how physician mental health can be protected and optimised, but uncertainty and misinformation remain about some key issues. In this Review, we discuss the current literature, which shows that despite what might be inferred during training, physicians are not immune to mental illness, with between a quarter and a third reporting increased symptoms of mental ill health. Physicians, particularly female physicians, are at an increased risk of suicide. An emerging consensus exists that some aspects of physician training, working conditions, and organisational support are unacceptable...
September 4, 2021: Lancet
#33
JOURNAL ARTICLE
Md Abul Ehsan Bhuiyan, Chandi Witharana, Anna K Liljedahl, Benjamin M Jones, Ronald Daanen, Howard E Epstein, Kelcy Kent, Claire G Griffin, Amber Agnew
Deep learning (DL) convolutional neural networks (CNNs) have been rapidly adapted in very high spatial resolution (VHSR) satellite image analysis. DLCNN-based computer visions (CV) applications primarily aim for everyday object detection from standard red, green, blue (RGB) imagery, while earth science remote sensing applications focus on geo object detection and classification from multispectral (MS) imagery. MS imagery includes RGB and narrow spectral channels from near- and/or middle-infrared regions of reflectance spectra...
September 17, 2020: Journal of Imaging
#34
JOURNAL ARTICLE
Ronald M Epstein, Frederick Marshall, Mechelle Sanders, Michael S Krasner
INTRODUCTION: Mindfulness-based interventions for health professionals have been linked to improvements in burnout, well-being, empathy, communication, patient-centered care, and patient safety, but the optimal formats and intensity of training have been difficult to determine because of the paucity of studies and the heterogeneity of programs. A 4-days residential "Mindful Practice" workshop for physicians and medical educators featuring contemplative practices, personal narratives, and appreciative dialogs about challenging experiences may hold promise in improving participants' well-being while also improving compassionate care, job satisfaction, work engagement, and teamwork...
January 1, 2022: Journal of Continuing Education in the Health Professions
#35
JOURNAL ARTICLE
Andrea Guennoun, Salim Bougarn, Taushif Khan, Rafah Mackeh, Mahbuba Rahman, Fatima Al-Ali, Manar Ata, Waleed Aamer, Debra Prosser, Tanwir Habib, Evonne Chin-Smith, Khawla Al-Darwish, Qian Zhang, Alya Al-Shakaki, Amal Robay, Ronald G Crystal, Khalid Fakhro, Amal Al-Naimi, Eman Al Maslamani, Amjad Tuffaha, Ibrahim Janahi, Mohammad Janahi, Donald R Love, Mohammed Yousuf Karim, Bernice Lo, Amel Hassan, Mehdi Adeli, Nico Marr
PURPOSE: Human serine/threonine kinase 4 (STK4) deficiency is a rare, autosomal recessive genetic disorder leading to combined immunodeficiency; however, the extent to which immune signaling and host defense are impaired is unclear. We assessed the functional consequences of a novel, homozygous nonsense STK4 mutation (NM_006282.2:c.871C > T, p.Arg291*) identified in a pediatric patient by comparing his innate and adaptive cell-mediated and humoral immune responses with those of three heterozygous relatives and unrelated controls...
November 2021: Journal of Clinical Immunology
#36
JOURNAL ARTICLE
Diana Naehrig, Aaron Schokman, Jessica Kate Hughes, Ronald Epstein, Ian B Hickie, Nick Glozier
OBJECTIVES: Clinician well-being has been recognised as an important pillar of healthcare. However, research mainly addresses mitigating the negative aspects of stress or burnout, rather than enabling positive aspects. With the added strain of a pandemic, identifying how best to maintain and support the well-being, satisfaction and flourishing of general practitioners (GPs) is now more important than ever. DESIGN: Systematic review. DATA SOURCES: We searched MEDLINE, PsycINFO, Embase, CINAHL and Scopus from 2000 to 2020...
August 18, 2021: BMJ Open
#37
JOURNAL ARTICLE
Ronald M Epstein
BACKGROUND: Epistemic uncertainty refers to situations in which available evidence is insufficient or unreliable, often accompanied by complexity due to novel contexts, multifactorial causation, and emerging options (the "unknowable unknown"). It stands in contrast to aleatory uncertainty where probabilities are known, and potential benefits and harms can be calculated and presented graphically (the "knowable unknown"). DISCUSSION: Epistemic uncertainty is common, and encompasses uncertainty about the nature of the illness, whom to entrust with one's care, and one's ability to adapt and cope...
November 2021: Patient Education and Counseling
#38
JOURNAL ARTICLE
Gina Tuch, Chandrika Sanapala, Supriya G Mohile, Paul R Duberstein, Enrique Soto-Perez-de-Celis, Huiwen Xu, Eva Culakova, Marie Flannery, Reza Yousefi-Nooraie, Ronald M Epstein, Colin McHugh, Valerie Aarne, Hannah Kim, Jodi Geer, Mark A O'Rourke, Nicholas J Vogelzang, Kah Poh Loh
BACKGROUND: Caregiver perceived autonomy support by the oncologist is important for caregiver well-being and may be affected by the patient's survival. We determined the association of caregiver-oncologist discordance in patient's life expectancy estimates with perceived autonomy support over time and whether the association differed by patient survival status. MATERIALS AND METHODS: We used data from a geriatric assessment cluster-randomized trial (URCC 13070) that recruited patients aged at least 70 years with incurable cancer considering or receiving treatment, their caregivers, and their oncologists...
November 2021: Oncologist
#39
JOURNAL ARTICLE
Fahad Saeed, Paul R Duberstein, Ronald M Epstein, Valerie J Lang, Scott E Liebman
INTRODUCTION: Moral distress is a negative affective response to a situation in which one is compelled to act in a way that conflicts with one's values. Little is known about the workplace scenarios that elicit moral distress in nephrology fellows. METHODS: We sent a moral distress survey to 148 nephrology fellowship directors with a request to forward it to their fellows. Using a 5-point (0-4) scale, fellows rated both the frequency (never to very frequently) and severity (not at all disturbing to very disturbing) of commonly encountered workplace scenarios...
2021: American Journal of Nephrology
#40
EDITORIAL
Ronald M Epstein, Michael R Privitera
No abstract text is available yet for this article.
July 2021: JCO oncology practice
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