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Ronald Epstein

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https://www.readbyqxmd.com/read/29148892/impact-of-prognostic-discussions-on-the-patient-physician-relationship-prospective-cohort-study
#1
Joshua J Fenton, Paul R Duberstein, Richard L Kravitz, Guibo Xing, Daniel J Tancredi, Kevin Fiscella, Supriya Mohile, Ronald M Epstein
Purpose Some research has suggested that discussion of prognosis can disrupt the patient-physician relationship. This study assessed whether physician discussion of prognosis is associated with detrimental changes in measures of the strength of the patient-physician relationship. Methods This was a longitudinal cohort study of 265 adult patients with advanced cancer who visited 38 oncologists within community- and hospital-based cancer clinics in Western New York and Northern California. Prognostic discussion was assessed by coding transcribed audio-recorded visits using the Prognostic and Treatment Choices (PTCC) scale and by patient survey at 3 months after the clinic visit...
November 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29109138/author-response-education-research-positive-effect-of-scheduled-faculty-modeling-on-clerkship-student-bedside-skills-exposure-and-learning
#2
Robert Thompson Stone, Trenton Tollefson, Ronald Epstein, Ralph F Jozefowicz, Jonathan W Mink
No abstract text is available yet for this article.
November 7, 2017: Neurology
https://www.readbyqxmd.com/read/28952370/preventive-dental-care-at-6-month-intervals-is-associated-with-reduced-caries-risk
#3
Valerie J Flaherman, Jacqueline Epstein, Louis Amendola, Ronald Inge, John D Featherstone, Megumi Okumura
No abstract text is available yet for this article.
March 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28892432/patient-clinician-communication-american-society-of-clinical-oncology-consensus-guideline
#4
REVIEW
Timothy Gilligan, Nessa Coyle, Richard M Frankel, Donna L Berry, Kari Bohlke, Ronald M Epstein, Esme Finlay, Vicki A Jackson, Christopher S Lathan, Charles L Loprinzi, Lynne H Nguyen, Carole Seigel, Walter F Baile
Purpose To provide guidance to oncology clinicians on how to use effective communication to optimize the patient-clinician relationship, patient and clinician well-being, and family well-being. Methods ASCO convened a multidisciplinary panel of medical oncology, psychiatry, nursing, hospice and palliative medicine, communication skills, health disparities, and advocacy experts to produce recommendations. Guideline development involved a systematic review of the literature and a formal consensus process. The systematic review focused on guidelines, systematic reviews and meta-analyses, and randomized controlled trials published from 2006 through October 1, 2016...
November 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28841847/the-social-and-behavioral-influences-sbi-study-study-design-and-rationale-for-studying-the-effects-of-race-and-activation-on-cancer-pain-management
#5
Cezanne M Elias, Cleveland G Shields, Jennifer J Griggs, Kevin Fiscella, Sharon L Christ, Joseph Colbert, Stephen G Henry, Beth G Hoh, Haslyn E R Hunte, Mary Marshall, Supriya Gupta Mohile, Sandy Plumb, Mohamedtaki A Tejani, Alison Venuti, Ronald M Epstein
BACKGROUND: Racial disparities exist in the care provided to advanced cancer patients. This article describes an investigation designed to advance the science of healthcare disparities by isolating the effects of patient race and patient activation on physician behavior using novel standardized patient (SP) methodology. METHODS/DESIGN: The Social and Behavioral Influences (SBI) Study is a National Cancer Institute sponsored trial conducted in Western New York State, Northern/Central Indiana, and lower Michigan...
August 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28806452/sharing-experiences-of-illness-and-care
#6
Louise Locock, Richard Lehman, Ronald M Epstein
No abstract text is available yet for this article.
September 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28659511/ronald-epstein-md-bringing-mindfulness-into-the-examination-room
#7
Ronald Epstein
Advances in Mind-Body Medicine (Advances): You have come out with a book recently, titled Attending: Medicine, Mindfulness, and Humanity. What was the motive for writing this book? Dr Epstein: I knew that it was time to expand beyond writing for medical audiences and peer-reviewed journals when 2 realizations struck me. One is that important change in medicine often comes from the outside in as opposed to from the inside out. The degree to which the public is educated and energized about an issue can produce a change in medicine...
April 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/28607143/education-research-positive-effect-of-scheduled-faculty-modeling-on-clerkship-student-bedside-skills-exposure-and-learning
#8
Robert Thompson Stone, Trenton Tollefson, Ronald Epstein, Ralph F Jozefowicz, Jonathan W Mink
OBJECTIVE: To evaluate the effect of scheduled bedside skills modeling for third-year medical students on their neurology clerkship. METHODS: During the 2012-2014 academic years, 56 third-year medical students participated in a curricular pilot program involving a scheduled bedside skills modeling experience during the first week of their neurology clerkship, whereas 131 students underwent the typical rotation. The experience consisted of observing a faculty member conduct a comprehensive encounter on a new outpatient...
June 13, 2017: Neurology
https://www.readbyqxmd.com/read/28602414/the-older-adult-with-locoregionally-advanced-head-and-neck-squamous-cell-carcinoma-knowledge-gaps-and-future-direction-in-assessment-and-treatment
#9
REVIEW
Ronald Maggiore, Zachary S Zumsteg, Karlynn BrintzenhofeSzoc, Kelly M Trevino, Ajeet Gajra, Beatriz Korc-Grodzicki, Joel B Epstein, Stewart M Bond, Ira Parker, Julie A Kish, Barbara A Murphy, Noam A VanderWalde
Older adults with head and neck squamous cell carcinoma (HNSCC) pose unique treatment and supportive care challenges to oncologists and other cancer care providers. The majority of patients with HNSCC present with locoregionally advanced disease, for which combined-modality treatment integrating chemotherapy and radiation therapy is often necessary to maximize tumor control. However, applying these approaches to an older population with concomitant comorbidities and a higher risk of functional impairments remains challenging and is exacerbated by the paucity of studies involving older adults...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28561649/mastering-resilience-in-oncology-learn-to-thrive-in-the-face-of-burnout
#10
Fay J Hlubocky, Miko Rose, Ronald M Epstein
Oncology clinician burnout has become a noteworthy issue in medical oncology directly affecting the quality of patient care, patient satisfaction, and overall organizational success. Due to the increasing demands on clinical time, productivity, and the evolving medical landscape, the oncology clinician is at significant risk for burnout. Long hours in direct care with seriously ill patients/families, limited control over daily responsibilities, and endless electronic documentation, place considerable professional and personal demands on the oncologist...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28552193/the-trio-framework-conceptual-insights-into-family-caregiver-involvement-and-influence-throughout-cancer-treatment-decision-making
#11
REVIEW
Rebekah Laidsaar-Powell, Phyllis Butow, Cathy Charles, Amiram Gafni, Vikki Entwistle, Ronald Epstein, Ilona Juraskova
OBJECTIVE: Family caregivers are regularly involved in cancer consultations and treatment decision-making (DM). Yet there is limited conceptual description of caregiver influence/involvement in DM. To address this, an empirically-grounded conceptual framework of triadic DM (TRIO Framework) and corresponding graphical aid (TRIO Triangle) were developed. METHODS: Jabareen's model for conceptual framework development informed multiple phases of development/validation, incorporation of empirical research and theory, and iterative revisions by an expert advisory group...
November 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28506538/epitope-specific-immunotherapy-targeting-cd4-positive-t-cells-in-coeliac-disease-two-randomised-double-blind-placebo-controlled-phase-1-studies
#12
Gautam Goel, Tim King, A James Daveson, Jane M Andrews, Janakan Krishnarajah, Richard Krause, Gregor J E Brown, Ronald Fogel, Charles F Barish, Roger Epstein, Timothy P Kinney, Philip B Miner, Jason A Tye-Din, Adam Girardin, Juha Taavela, Alina Popp, John Sidney, Markku Mäki, Kaela E Goldstein, Patrick H Griffin, Suyue Wang, John L Dzuris, Leslie J Williams, Alessandro Sette, Ramnik J Xavier, Ludvig M Sollid, Bana Jabri, Robert P Anderson
BACKGROUND: A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free mix of three peptides that include immunodominant epitopes for gluten-specific CD4-positive T cells. The vaccine is intended to engage and render gluten-specific CD4-positive T cells unresponsive to further antigenic stimulation. We assessed the safety and pharmacodynamics of the vaccine in patients with coeliac disease on a gluten-free diet...
July 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28466666/european-and-russian-physician-awareness-of-best-management-approaches-for-infections-due-to-antibiotic-resistant-gram-negative-bacteria
#13
Paurus Irani, Tehseen Salimi, Robert Epstein, Megan Leone-Perkins, Ronald Aubert, Mona Khalid, Emma Epstein, J Russell Teagarden
OBJECTIVES: The rapid spread of infections due to antibiotic-resistant, Gram-negative bacteria in Europe and surrounding regions requires a heightened level of awareness among physicians within their practice settings. METHODS: We surveyed 800 physicians who treat these infections across France, Germany, Spain, Italy, and Russia to assess their awareness of best management approaches. RESULTS: We found that more than two-thirds do not consider themselves highly aware of best management practices...
May 25, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28349411/what-s-the-opposite-of-burnout
#14
Ronald M Epstein
No abstract text is available yet for this article.
July 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28277698/does-educating-patients-about-the-early-palliative-care-study-increase-preferences-for-outpatient-palliative-cancer-care-findings-from-project-empower
#15
Michael Hoerger, Laura M Perry, Robert Gramling, Ronald M Epstein, Paul R Duberstein
OBJECTIVES: Randomized controlled trials, especially the Early Palliative Care Study (Temel et al., 2010), have shown that early outpatient palliative cancer care can improve quality of life for patients with advanced cancer or serious symptoms. However, fear and misconceptions drive avoidance of palliative care. Drawing from an empowerment perspective, we examined whether educating patients about evidence from the Early Palliative Care Study would increase preferences for palliative care...
June 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28239644/hla-dq-%C3%AE-1-alleles-associated-with-epstein-barr-virus-ebv-infectivity-and-ebv-gp42-binding-to-cells
#16
Qingxue Li, Wei Bu, Erin Gabriel, Fiona Aguilar, Yo Hoshino, Hiroko Miyadera, Christoph Hess, Ronald L Hornung, Amitava Roy, Jeffrey I Cohen
Epstein-Barr virus (EBV) infects B cells and ~95% of adults are infected. EBV glycoprotein gp42 is essential for entry of virus into B cells. EBV gp42 binds to the β1 chain of HLA-DQ, -DR, and -DP on B cells, and uses these molecules for infection. To investigate if certain HLA-DQ alleles are associated with EBV seronegativity, we recruited ~3,300 healthy adult blood donors, identified 106 EBV-seronegative individuals, and randomly selected a control group of EBV-seropositive donors from the donor pool. A larger than expected proportion of EBV-seronegative subjects were HLA-DQ β1 *04/*05 and *06/*06, and to a lesser extent, *02/*03, compared with the control group, while a larger than expected portion of EBV-seropositive persons were HLA-DQ β1 *02/*02...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28167571/pharmacoepidemiology-of-clinically-relevant-hypothyroidism-and-hypertension-from-sunitinib-and-sorafenib
#17
Christine M Walko, Ronald E Aubert, Ninh M La-Beck, Gosia Clore, Vivian Herrera, Helen Kourlas, Robert S Epstein, Howard L McLeod
BACKGROUND: Thyroid dysfunction and hypertension (HTN) have been sporadically reported with sunitinib (SUN) and sorafenib (SOR). Determination of the side effect incidence will enhance monitoring and management recommendations. METHODS: An observational cohort study was performed using deidentified pharmacy claims data from a 3-year period to evaluate patients prescribed SUN, SOR, or capecitabine (CAP; comparison group). The primary outcome was time to first prescription for thyroid replacement or HTN treatment...
February 2017: Oncologist
https://www.readbyqxmd.com/read/28156512/a-cluster-randomized-trial-of-a-patient-centered-communication-intervention-in-advanced-cancer-the-values-and-options-in-cancer-care-voice-study
#18
Richard L Kravitz, Paul Duberstein, Daniel J Tancredi, Guibo Xing, Ronald M Epstein
2 Background: Observational studies demonstrate links between patient-centered communication, prognosis discordance, quality of life (QoL) and aggressive treatments near the end of life, yet there are few randomized evaluations of communication interventions in advanced cancer. METHODS: We completed a cluster randomized controlled trial in cancer clinics in Western NY and Northern CA with medical oncologists (n = 38 randomized to intervention or control) and their community-dwelling adult patients with advanced non-hematologic cancer (n = 265; 194 with enrolled caregivers)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28135140/promoting-end-of-life-discussions-in-advanced-cancer-effects-of-patient-coaching-and-question-prompt-lists
#19
RANDOMIZED CONTROLLED TRIAL
Rachel A Rodenbach, Kim Brandes, Kevin Fiscella, Richard L Kravitz, Phyllis N Butow, Adam Walczak, Paul R Duberstein, Peter Sullivan, Beth Hoh, Guibo Xing, Sandy Plumb, Ronald M Epstein
Purpose To build on results of a cluster randomized controlled trial (RCT) of a combined patient-oncologist intervention to improve communication in advanced cancer, we conducted a post hoc analysis of the patient intervention component, a previsit patient coaching session that used a question prompt list (QPL). We hypothesized that intervention-group participants would bring up more QPL-related topics, particularly prognosis-related topics, during the subsequent oncologist visit. Patients and Methods This cluster RCT with 170 patients who had advanced nonhematologic cancer (and their caregivers) recruited from practices of 24 participating oncologists in western New York...
March 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27982024/epstein-barr-virus-positive-follicular-lymphoma
#20
Nicholas Mackrides, German Campuzano-Zuluaga, Yvan Maque-Acosta, Adrienne Moul, Nouf Hijazi, Francis Offiong Ikpatt, Ronald Levy, Ramiro E Verdun, Kranthi Kunkalla, Yasodha Natkunam, Izidore S Lossos, Francisco Vega, Jennifer Chapman
Epstein-Barr virus (EBV) -associated follicular lymphoma is only rarely reported. Herein, we report the largest series analyzing prevalence and clinicopathologic characteristics of EBV-associated follicular lymphoma occurring in unselected cases. Out of 382 analyzed cases, 10 EBV-positive follicular lymphomas were identified (prevalence=2.6%, 95% confidence interval 1.3-4.0%). All EBV-positive follicular lymphomas showed EBV-encoded small RNA-positive lymphoma cells present in a follicular distribution. Of these, eight also had tissue available for testing of expression of latent membrane protein 1 (LMP1), out of which six (75%) were positive...
April 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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