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https://www.readbyqxmd.com/read/28526521/coexistence-of-aspergilloma-and-pulmonary-hydatid-cyst-in-an-immunocompetent-individual
#1
F Aala, H Badali, S Hashemi Fesharaki, M Boroumand, M Sotoudeh Anvari, H Davari, S Agha Kuchak Afshari, S Khodavaisy
Echinococcosis is a zoonotic disease caused by Echinococcus granulosus sensu lato. The liver and lungs are the most commonly sites of infections, but involvements of other organs were also observed. Recently, the coinfection of pulmonary hydatid cyst with aspergilloma has been reported in the literature. Herein, we report a successful treatment of coinfection of cystic echinoccosis with aspergilloma due to Aspergillus flavus in a 34-year-old female. In vitro antifungal susceptibility tests revealed that the MIC values for antifungals employed in this case were posaconazole (0...
May 16, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28513812/common-dermatophytes-and-in-vitro-anti-fungal-susceptibility-testing-in-patients-attending-the-dermatological-clinic-at-the-hospital-for-tropical-medicine-bangkok
#2
Watcharamat Muangkaew, Thanwa Wongsuk, Natthanej Luplertlop
Dermatophytes comprising the genera Trichophyton, Microsporum, and Epidermophyton are important causes of superficial mycoses. The number of infected patients and the distribution of species of these organisms in our hospital were unknown. We therefore aimed to investigate the clinical pattern of dermatophyte infections and to identify the species of these dermatophytes at the Dermatological Clinic of the Hospital for Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok in a 1-year period...
May 17, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28513771/species-distribution-and-antifungal-susceptibility-patterns-of-candida-isolates-from-a-public-tertiary-teaching-hospital-in-the-eastern-cape-province-south-africa
#3
P Mnge, B I Okeleye, S D Vasaikar, T Apalata
Candida species are the leading cause of invasive fungal infections, and over the past decade there has been an increased isolation of drug resistant Candida species. This study aimed to identify the species distribution of Candida isolates and to determine their unique antifungal susceptibility and resistance patterns. During a cross-sectional study, 209 Candida isolates (recovered from 206 clinical samples) were collected and their species distribution was determined using ChromAgar Candida. The Vitek-2 system (Biomerieux, South Africa) was used to determine minimum inhibitory concentrations (MICs) to azoles (fluconazole, voriconazole), echinocandins (caspofungin, micafungin), polyenes (amphotericin B) and flucytosine...
May 15, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28511380/fungal-profile-of-vulvovaginal-candidiasis-in-a-tertiary-care-hospital
#4
Krishnapriya Kalaiarasan, Rakesh Singh, Latha Chaturvedula
INTRODUCTION: Vulvovaginal Candidiasis (VVC) is a common medical health problem of adult women. It is most commonly caused by Candida albicans. But there is a change in fungal profile. Sabouraud's Dextrose Agar (SDA) is the most common culture medium used where mixed fungal infection may be missed. It can be detected easily by using chromogenic culture medium. AIM: To know the fungal profile of vulvovaginal candidiasis using Candida CHROMagar and antifungal susceptibility pattern in patients attending tertiary care hospital...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28510690/trichosporonosis-in-pediatric-patients-with-a-hematologic-disorder
#5
Catherine E Foster, Morven S Edwards, Julienne Brackett, Deborah A Schady, C Mary Healy, Carol J Baker
Background.: Trichosporonosis is an emerging and often fatal opportunistic fungal infection in immunocompromised patients, particularly those with hematologic malignancy, but data in children are lacking. Methods.: We report here 3 cases of invasive infection caused by Trichosporon asahii in pediatric patients with acute lymphoblastic leukemia at Texas Children's Hospital in Houston, Texas. We also conducted a literature review and identified 16 additional reports of pediatric patients with invasive T asahii infection and an underlying malignant or nonmalignant hematologic disorder...
May 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28507937/the-utilization-of-rna-silencing-technology-to-mitigate-the-voriconazole-resistance-of-aspergillus-flavus-lipofectamine-based-delivery
#6
Sanam Nami, Behzad Baradaran, Behzad Mansoori, Parivash Kordbacheh, Sasan Rezaie, Mehraban Falahati, Leila Mohamed Khosroshahi, Mahin Safara, Farideh Zaini
Purpose: Introducing the effect of RNAi in fungi to downregulate essential genes has made it a powerful tool to investigate gene function, with potential strategies for novel disease treatments. Thus, this study is an endeavor to delve into the silencing potentials of siRNA on cyp51A and MDR1 in voriconazole-resistant Aspergillus flavus as the target genes. Methods: In this study, we designed three cyp51A-specific siRNAs and three MDR1-specific siRNAs and after the co-transfection of siRNA into Aspergillus flavus, using lipofectamine, we investigated the effect of different siRNA concentrations (5, 15, 25, 50nM) on cyp51A and MDR1 expressions by qRT-PCR...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28506251/diversity-in-vitro-virulence-traits-and-antifungal-susceptibility-pattern-of-gastrointestinal-yeast-flora-of-healthy-poultry-gallus-gallus-domesticus
#7
Supram Hosuru Subramanya, Nawal Kishor Sharan, Bharat Prasad Baral, Deependra Hamal, Niranjan Nayak, Peralam Yegneswaran Prakash, Brijesh Sathian, Indira Bairy, Shishir Gokhale
BACKGROUND: Poultry farming and consumption of poultry (Gallus gallus domesticus) meat and eggs are common gastronomical practices worldwide. Till now, a detailed understanding about the gut colonisation of Gallus gallus domesticus by yeasts and their virulence properties and drug resistance patterns in available literature remain sparse. This study was undertaken to explore this prevalent issue. RESULTS: A total of 103 specimens of fresh droppings of broiler chickens (commercial G domesticus) and domesticated chickens (domesticated G domesticus) were collected from the breeding sites...
May 15, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28505263/substantial-impairment-of-voriconazole-clearance-by-high-dose-meropenem-in-a-patient-with-renal-failure
#8
Mazyar Mahmoudi, Thorsten Brenner, Gencay Hatiboglu, Jürgen Burhenne, Johanna Weiss, Markus A Weigand, Walter E Haefeli
A critically ill patient with multiple postoperative infections repeatedly required profound voriconazole dose reductions whenever high-dose meropenem was added. Subsequent in vitro assessment confirmed inhibition of cytochrome P450 (CYP) 2C19 and CYP3A4 by meropenem, suggesting that during meropenem narrow therapeutic index drugs metabolized by these CYPs will require close monitoring.
May 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28504057/molecular-dynamic-modeling-of-cyp51b-in-complex-with-azole-inhibitors
#9
Pan Gao, Yinglu Cui, Rongling Wu
Cytochrome P450 14α-sterol demethylase (CYP51), the key enzyme in sterol biosynthesis pathway, is an important target protein of cholesterol-lowering agents, antifungal drugs and herbicides. CYP51B enzyme is one of the CYP51 family members. In the present study, we have chosen four representative inhibitors of CYP51B: diniconazole(Din), fluconazole(Flu), tebuconazole(Teb), voriconazole(Vor) and launched to investigate the binding features of CYP51B-inhibitor and gating characteristics via molecular docking and molecular dynamics(MD) simulations...
May 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28501467/keratitis-by-a-rare-pathogen-colletotrichum-gloeosporioides-a-case-report
#10
S T Pote, A Chakraborty, K K Lahiri, M S Patole, R A Deshmukh, S R Shah
Colletotrichum species have been reported infrequently as the cause of keratitis or subcutaneous lesions. The patient we describe developed keratitis after ocular trauma. The sample from the corneal scrapings grew Colletotrichum gloeosporioides as identified from morphological characters and DNA sequence of the 'Internal Transcribed Spacer' (ITS) region. The patient underwent topical application of amphotericin-B followed by itraconazole and natamycin treatment. Simultaneous oral voriconazole regimen leads to complete regression of corneal ulcer...
May 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28499959/impact-of-initial-empirical-antifungal-agents-on-the-outcome-of-critically-ill-patients-with-invasive-candidiasis-analysis-of-the-china-scan-study
#11
Na Cui, Hao Wang, Haibo Qiu, Ruoyu Li, Dawei Liu
The effect of different empirical antifungal agents on the clinical outcome of critically ill patients with invasive candidiasis (IC) has not been fully elucidated. In this study, 136 patients with proven IC who received empirical therapy in the China-SCAN multicentre study were retrospectively analysed. Initial empirical antifungal monotherapy consisted of a triazole [fluconazole (n = 61), voriconazole (n = 20) or itraconazole (n = 12)] or an echinocandin (n = 43). Hospital mortality as the primary outcome and global responses (clinical and microbiological) were assessed...
May 9, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28497621/endomyocardial-and-pericardial-aspergillosis-in-critically-ill-patients
#12
George Dimopoulos, Frantzeska Frantzeskaki, Marinos Kosmopoulos, Fabio Sylvio Taccone, Anne-Marie Van den Abeele, Pierre Bulpa, Frederic Forêt, Dirk Vogelaers, Stijn Blot
Invasive aspergillosis(IA) is a potentially lethal complication of Aspergillus infection affecting mainly immunocompromised hosts; however, during the last two decades its incidence was increasingly observed in critically ill immunocompetent patients. The objective of this study is to describe the clinical characteristics of histologically proven endomyocardial and pericardial invasion, in the context of IA, in critically ill patients. Eight critically ill patients with histopathological confirmation of endomyocardial/pericardial aspergillosis were evaluated...
May 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28497121/implementation-of-isavuconazole-in-a-fluorescence-based-high-performance-liquid-chromatography-kit-allowing-simultaneous-detection-of-all-four-currently-licensed-mold-active-triazoles
#13
René Jørgensen, Siri Rytcher Andersen, Karen Marie Thyssen Astvad, Maiken Cavling Arendrup
Isavuconazole (ISZ) is a newly available broad-spectrum triazole agent recently approved for the treatment of both invasive aspergillosis and mucormycosis. The aim of this study was to develop a simple and reliable method for therapeutic drug monitoring (TDM) of ISZ in human plasma samples. The method involves using a kit from ChromSystems intended for TDM of itraconazole (ITZ), posaconazole (PSZ), and voriconazole (VRZ) in serum/plasma for sample preparation and high-performance liquid chromatography, using fluorescence detection with emission and excitation wavelengths set to 261 and 366 nm, respectively...
May 2017: MSphere
https://www.readbyqxmd.com/read/28493006/activity-of-combined-antifungal-agents-against-multidrug-resistant-candida-glabrata-strains
#14
Laura Bedin Denardi, Jéssica Tairine Keller, Vanessa Oliveira, Débora Alves Nunes Mario, Janio Morais Santurio, Sydney Hartz Alves
In this study, we evaluated the in vitro activity of echinocandins, azoles, and amphotericin B alone and in combination against echinocandin/azole-sensitive and echinocandin/azole-resistant Candida glabrata isolates. Susceptibility tests were performed using the broth microdilution method in accordance with the Clinical and Laboratory Standards Institute document M27-A3. The checkerboard method was used to evaluate the fractional inhibitory concentration index of the interactions. Cross-resistance was observed among echinocandins; 15% of the isolates resistant to caspofungin were also resistant to anidulafungin and micafungin...
May 10, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28487449/voriconazole-induced-periostitis-deformans-a-mimicker-of-hpoa
#15
Karim Ladak, Laurence Rubin
No abstract text is available yet for this article.
May 9, 2017: Clinical Medicine & Research
https://www.readbyqxmd.com/read/28483963/influence-of-experimental-cryptococcal-meningitis-in-wistar-rats-on-voriconazole-brain-penetration-assessed-by-microdialysis
#16
Izabel Almeida Alves, Keli Jaqueline Staudt, Carolina de Miranda Silva, Graziela de Araujo Lock, Teresa Dalla Costa, Bibiana Verlindo de Araujo
To advance in the treatment of cryptococcal meningites is crucial to know the drug's free fraction that reaches the biophase. In the present study we applied the microdialysis (μD) as a tool to determine the free levels reached by voriconazole (VRC) in the brain of healthy and Cryptococcus neoformans infected rats. The infection was induced by the i.v. administration of 1⋅10(5) CFU of yeast. The dose administered was 5 mg/kg i.v. of VRC. Plasma and microdialysate samples were analyzed by LC-MS/MS and LC-UV methods...
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28483956/the-tetrazole-vt-1161-is-a-potent-inhibitor-of-trichophyton-rubrum-through-its-inhibition-of-t-rubrum-cyp51
#17
Andrew G S Warrilow, Josie E Parker, Claire L Price, Edward P Garvey, William J Hoekstra, Robert J Schotzinger, Nathan P Wiederhold, W David Nes, Diane E Kelly, Steven L Kelly
Prior to characterization of antifungal inhibitors that target this enzyme, Trichophyton rubrum CYP51 was expressed in Escherichia coli, purified and characterized. T. rubrum CYP51 bound lanosterol, obtusifoliol and eburicol with similar affinities (Kd values 22.7, 20.3 and 20.9 μM), but displayed substrate specificity insofar as only eburicol was demethylated in CYP51 reconstitution assays (turnover number 1.55 min(-1), Km value 2 μM). The investigational agent VT-1161 bound tightly to T. rubrum CYP51 (Kd = 242 nM) with similar affinity as clotrimazole, fluconazole, ketoconazole and voriconazole (Kd values 179, 173, 312, and 304 nM, respectively), and with lower affinity than itraconazole (Kd = 53 nM)...
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28483449/luliconazole-an-alternative-antifungal-agent-against-aspergillus-terreus
#18
M Zargaran, S Taghipour, N Kiasat, E Aboualigalehdari, A Rezaei-Matehkolaei, A Zarei Mahmoudabadi, F Shamsizadeh
Aspergillus terreus is the fourth leading cause of invasive and non-invasive aspergillosis and one of the causative agents of morbidity and mortality among immunocompromised and high-risk patients. A. terreus appears to have increased as a cause of opportunistic fungal infections from superficial to serious invasive infections. Although, invasive aspergillosis is often treated empirically with amphotericin B, most A. terreus isolates are resistant both in vivo and in vitro to some antifungal drugs. In this study, we aimed to evaluate antifungals susceptibility profiles of the different strains of A...
May 5, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28482780/voriconazole-induced-hyponatraemia-associated-with-homozygous-cyp2c19-2-genotype
#19
Sharon Ho, Matthew Rawlins, Paul Ingram, Peter Boan
No abstract text is available yet for this article.
May 8, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28482076/genotyping-of-clinical-isolates-of-candida-glabrata-from-iran-by-multilocus-sequence-typing-and-determination-of-population-structure-and-drug-resistance-profile
#20
Saeid Amanloo, Masoomeh Shams-Ghahfarokhi, Mohammad Ghahri, Mehdi Razzaghi-Abyaneh
Candida glabrata is often the second most common causative agent for candidiasis following Candida albicans. Despite the importance of C. glabrata infections, few epidemiological studies have been conducted on this issue. The goal of this study was genotyping of clinical isolates of C. glabrata by multilocus sequence typing (MLST) technique for determination of the endemic prevalent genotypes and any association between isolation source and drug resistance. A total of 50 C. glabrata clinical isolates from Iran were analyzed by MLST and tested for in-vitro susceptibilities to amphotericin-B, caspofungin, fluconazole, and voriconazole according to the Clinical Laboratory Standards Institute (CLSI) M27-A4 document guidelines...
May 6, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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