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Voriconazol

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https://www.readbyqxmd.com/read/29778564/simultaneous-quantification-of-systemic-azoles-and-their-major-metabolites-in-human-serum-by-hplc-pda-role-of-azole-metabolic-rate
#1
Alicia Gomez-Lopez, Laura Alcazar-Fuoli, Leticia Bernal-Martínez
We describe the development and validation of a novel liquid chromatography assay (HPLC/PDA) for simultaneous quantification of voriconazole, itraconazole, and posaconazole, as well as some of their major metabolites, voriconazole N-oxide and hydroxy-itraconazole, in human serum. Analytes were detected using a PDA system that allows the characterization of the specific UV spectra of each compound. The assay exhibited linearity between 0.25-16 mg/L for all the compounds tested. The accuracy and within- and between-day precision of the assay were in acceptable ranges...
April 14, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29771861/vincristine-associated-neuropathy-with-antifungal-usage-a-kaiser-northern-california-experience
#2
Mina Nikanjam, Aida Sun, Mark Albers, Kristine Mangalindin, Eyun Song, Hyma Vempaty, Danny Sam, Edmund V Capparelli
The dose-limiting toxicity for vincristine is peripheral neuropathy which can be potentiated with concurrent usage of azole antifungals. The current retrospective study assessed the incidence of concurrent vincristine and azole antifungal usage to determine if it led to increased neurotoxicity for the Kaiser Northern California pediatric acute lymphoblastic leukemia (ALL) and Hodgkin lymphoma patient population. Data were obtained from the electronic medical record (2007 to 2014). In total, 130 subjects received at least one dose of vincristine for ALL or Hodgkin lymphoma (median age 9, 88% ALL, 58% male, 47% Caucasian)...
May 16, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29770723/the-impact-of-azole-antifungal-drugs-on-imatinib-metabolism-in-human-liver-microsomes
#3
Xingxian Luo, Taifeng Li, Ze Yu, Xuecai Xue, Haiyang Zhao, Na Li, Liping Ma, Changqing Yang, Lin Huanglin, Wangyu Feng
1. Imatinib is widely used for the treatment of hematologic malignancies. It is common that imatinib is clinically co-prescribed with azole antifungal agents since these patients are more prone to invasive antifungal infection. The present study was to investigate the effects of azole antifungal drugs, including ketoconazole, fluconazole, voriconazole, itraconazole and posaconazole on imatinib metabolism. 2. The main metabolites, 1-OH midazolam and N-desmethyl imatinib, were determined in the absence and in the presence of various levels of ketoconazole, fluconazole, voriconazole, itraconazole and posaconazole...
May 17, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29767615/relevance-of-antifungal-penetration-in-biofilm-associated-resistance-of-candida-albicans-and-non-albicans-candida-species
#4
Rachna Singh, Anjna Kumari, Karminder Kaur, Parul Sethi, Arunaloke Chakrabarti
The role of penetration limitation in Candida biofilm-associated antifungal resistance remains unclear. Most of the previous work has been done on Candida albicans, although non-albicans (NAC) species are also implicated in invasive candidiasis and the biofilm matrix has been shown to vary amongst different species. Only a few studies have evaluated clinical isolates. This study aimed to determine the relevance of penetration limitation in the antifungal resistance of biofilms formed by C. albicans and NAC clinical isolates, using an agar disk diffusion assay...
May 16, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29766554/primary-cutaneous-aspergillosis-at-the-site-of-cyanoacrylate-skin-adhesive-in-a-neonate
#5
Ayan Kusari, Jessica Sprague, Lawrence F Eichenfield, Catalina Matiz, Victoria R Barrio
Primary cutaneous aspergillosis is a rare but potentially life-threatening disease. We present the case of a premature infant who developed primary cutaneous aspergillosis with Aspergillus niger at the site of a skin abrasion that had been treated with a purple-colored cyanoacrylate product. The infection was treated successfully with gentle debridement of the cyanoacrylate product, followed by intravenous voriconazole and topical fluconazole. To our knowledge, this is the first reported case of primary cutaneous aspergillosis occurring at the site of cyanoacrylate-based skin adhesive...
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29760306/necessity-for-a-significant-maintenance-dosage-reduction-of-voriconazole-in-patients-with-severe-liver-cirrhosis-child-pugh-class-c
#6
Takehiro Yamada, Shungo Imai, Yasuyuki Koshizuka, Yuki Tazawa, Keisuke Kagami, Naoki Tomiyama, Ryosuke Sugawara, Akira Yamagami, Tsuyoshi Shimamura, Ken Iseki
Therapeutic drug monitoring for voriconazole, an antifungal agent, is essential for maximizing efficacy and preventing toxicity. The aim of this study was to elucidate the optimal maintenance dose of voriconazole in patients with severe liver cirrhosis (Child-Pugh class C) by reviewing the plasma trough concentrations obtained by therapeutic drug monitoring and daily doses of voriconazole. We retrospectively evaluated 6 patients with Child-Pugh class C cirrhosis who received oral voriconazole treatment and were liver transplant recipients or were awaiting liver transplantation...
May 11, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29760132/a-multimodal-imaging-approach-enables-in-vivo-assessment-of-antifungal-treatment-in-a-mouse-model-of-invasive-pulmonary-aspergillosis
#7
Jennifer Poelmans, Uwe Himmelreich, Liesbeth Vanherp, Luca Zhai, Amy Hillen, Bryan Holvoet, Sarah Belderbos, Matthias Brock, Johan Maertens, Greetje Vande Velde, Katrien Lagrou
Aspergillus fumigatus causes life-threatening lung infections in immunocompromised patients. Mouse models are extensively used in research to assess the in vivo efficacy of antifungals. In recent years, there has been an increasing interest in the use of non-invasive imaging techniques to evaluate experimental infections. However, single imaging modalities have limitations concerning the type of information they can provide. In this study, magnetic resonance imaging and bioluminescence imaging were combined to obtain longitudinal information on the extent of developing lesions and fungal load in a leucopenic mouse model of IPA...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29758184/therapeutic-penetrating-keratoplasty-button-cultures-in-the-mycotic-ulcer-treatment-trial-ii-a-randomized-trial-comparing-oral-voriconazole-vs-placebo
#8
Julie Cho, N Venkatesh Prajna, Prajna Lalitha, Revathi Rajaraman, Tiruvengada Krishnan, Yijie Brittany Lin, Kathryn J Ray, Thomas M Lietman, Jennifer Rose-Nussbaumer
OBJECTIVE: To compare oral voriconazole versus placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis. DESIGN: Non-prespecified, secondary case-control analysis from a multicenter, double-masked, randomized placebo-controlled clinical trial STUDY PARTICIPANTS: Patients with smear-positive filamentous fungal ulcers and visual acuity of 20/400 or worse who eventuated to therapeutic penetrating keratoplasty (TPK). INTERVENTION: Study participants were randomized to oral voriconazole versus oral placebo; all received topical antifungal drops...
May 11, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750016/spotlight-on-isavuconazole-in-the-treatment-of-invasive-aspergillosis-and-mucormycosis-design-development-and-place-in-therapy
#9
REVIEW
Jeffrey D Jenks, Helmut Jf Salzer, Juergen Prattes, Robert Krause, Dieter Buchheidt, Martin Hoenigl
In recent decades, important advances have been made in the diagnosis and treatment of invasive aspergillosis (IA) and mucormycosis. One of these advances has been the introduction of isavuconazole, a second-generation broad spectrum triazole with a favorable pharmacokinetic and safety profile and few drug-drug interactions. Phase III trials in patients with IA and mucormycosis demonstrated that isavuconazole has similar efficacy to voriconazole for the treatment of IA (SECURE trial) and liposomal amphotericin B for the treatment of mucormycosis (VITAL trial with subsequent case-control analysis) and a favorable safety profile with significantly fewer ocular, hepatobiliary, and skin and soft tissue adverse events compared to voriconazole...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29748145/design-synthesis-and-evaluation-of-benzoheterocycle-analogues-as-potent-antifungal-agents-targeting-cyp51
#10
Shizhen Zhao, Peng Wei, Mengya Wu, Xiangqian Zhang, Liyu Zhao, Xiaolin Jiang, Chenzhou Hao, Xin Su, Dongmei Zhao, Maosheng Cheng
To further enhance the anti-Aspergillus efficacy of our previously discovered antifungal lead compound 1, a series of benzoheterocycle analogues were designed, synthesized and evaluated for their in vitro antifungal activity. The most promising compounds 13s and 14a exhibited excellent antifungal activity against C. albicans, C. neoformans, A. fumigatus and fluconazole-resistant C. albicans strains, that was superior or comparable to those of the reference drugs fluconazole and voriconazole. GC-MS analyses suggested that the novel compound 13s might have a similar mechanism to fluconazole by inhibiting fungal lanosterol 14α-demethylase (CYP51)...
April 27, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29747356/-research-on-the-surgery-treatment-and-etiology-of-fungal-endophthalmitis
#11
H Y Zhou, J J Ye, Y Y Chen, F T Dong
Objective: To evaluate the efficacy of vitrectomy and etiological diagnosis in the treatment of fungal endophthalmitis. Methods: A retrospective survey was done on the clinical manifestation, etiological diagnosis and treatment efficacy of 15 patients (15 eyes) who had been diagnosed with fungal endophthalmitis at the inpatient department of Peking Union Medical College Hospital during 2002-2015. A total of 15 eyes of 15 patients, 3 male and 12 female patients, were included in this study. The mean age of the patients was (45...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29747155/manual-punch-versus-automated-flow-through-sample-desorption-for-dried-blood-spot-lc-ms-ms-analysis-of-voriconazole
#12
Lisa C Martial, Erik van den Hombergh, Cornelis Tump, Otto Halmingh, David M Burger, Erik M van Maarseveen, Roger J Brüggemann, Rob E Aarnoutse
Dried blood spot (DBS) sampling is a patient-friendly alternative for plasma sampling for the purpose of therapeutic drug monitoring (TDM). To speed up the analysis time, an automated flow-through desorption method of DBS samples may be beneficial. This article describes the cross-validation of a manual punch DBS method with an automated desorption (DBS autosampler, DBSA) method for the DBS analysis of the antifungal drug voriconazole, followed by cross-validation of both DBS methods with a plasma-based method, and an assessment of agreement between DBS/DBSA and regular plasma concentration measurements (gold standard) in samples from patients on voriconazole treatment...
April 27, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29744898/moderate-correlation-between-systemic-il-6-responses-and-crp-with-trough-concentrations-of-voriconazole
#13
Bas Vreugdenhil, Walter J F M van der Velden, Ton Feuth, Matthijs Kox, Peter Pickkers, Frank L van de Veerdonk, Nicole M A Blijlevens, Roger J M Brüggemann
BACKGROUND: Voriconazole (VCZ) exhibits a wide intra-patient pharmacokinetic variability, which is disadvantageous because of the narrow-therapeutic range of VCZ. A considerable part of this variation remains unexplainable despite extensive knowledge of this drug. It is hypothesized that inflammation has an impact on voriconazole pharmacokinetics. In this study we investigated the correlation between voriconazole trough concentrations and various cytokines. METHODS: A prospective single center analysis was performed in adult hematology patients receiving voriconazole for possible, probable or proven IFD...
May 9, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29743305/five-year-national-surveillance-of-invasive-candidiasis-species-distribution-and-azole-susceptibility-from-the-china-hospital-invasive-fungal-surveillance-net-chif-net-study
#14
Meng Xiao, Zi-Yong Sun, Mei Kang, Da-Wen Guo, Kang Liao, Sharon C-A Chen, Fanrong Kong, Xin Fan, Jing-Wei Cheng, Xin Hou, Meng-Lan Zhou, Ying Li, Shu-Ying Yu, Jing-Jing Huang, He Wang, Ying-Chun Xu
Data on the epidemiology of invasive candidiasis (IC) and antifungal susceptibility of Candida isolates in China are still limited. Here we report surveillance for IC from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study. Sixty-five tertiary hospitals collected 8,829 Candida isolates from August 1, 2009 to July 31, 2014. Matrix-assisted laser desorption/ionization -time of flight mass spectrometry supplemented by rDNA sequencing was used to define species, and fluconazole and voriconazole susceptibilities determined by the Clinical and Laboratory Standards Institute disk diffusion method...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29739053/fungal-infection-caused-by-geotrichum-capitatum-in-a-severe-aplastic-anemia-patient-a-case-report-and-review-of-the-literature
#15
Wulin Shan, Chunyang Dai, Jingsong Kan, Ming Li, Meiling Yin
BACKGROUND: Invasive fungal infections often occur in immunocompromised patients. Here, we report an infection case caused by Geotrichum capitatum in a severe aplastic anemia patient. METHODS: Identification of the pathogenic bacteria was done by sequencing and mass spectrometric analysis. RESULTS: The fungal infection was isolated from blood cultures. The pathogenic bacteria were identified as Geotrichum capitatum. The infection was primarily cured by voriconazole and caspofungin monotherapy...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29737099/-determination-of-voriconazole-in-human-plasma-and-its-bioequivalence-by-hplc-ms-ms
#16
Jin Xiang, Qin Yu, Mao-Zhi Liang, Yong-Ping Qin, Feng Nan
OBJECTIVE: To develop a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for the determination of voriconazole in human plasma and its bioequivalence. METHODS: 48 healthy male volunteers received a single dose of 200 mg voriconazole tablets in a two period (with two preparations) and randomized crossover bioequivalence study. Their plasma voriconazole was determined using HPLC-MS/MS. The pharmacokinetic parameters and bioequivalence of the two preparations were calculated with WinNonlin® 6...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29735820/-fusarium-the-versatile-pathogen
#17
REVIEW
Ananya Tupaki-Sreepurna, Anupma Jyoti Kindo
Fusarium is an emerging human opportunistic pathogen of growing importance, especially among immunosuppressed haematology patients due to an increased incidence of disseminated infections over the past two decades. This trend is expected only to continue due to the advances in medical and surgical technologies that will prolong the lives of the severely ill, making these patients susceptible to rare opportunistic infections. Production of mycotoxins, enzymes such as proteases, angio-invasive property and an intrinsically resistant nature, makes this genus very difficult to treat...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735569/isavuconazole-concentration-in-real-world-practice-consistency-with-results-from-clinical-trials
#18
David Andes, Laura Kovanda, A Desai, Theresa Kitt, M Zhao, Thomas J Walsh
Clinical use of voriconazole, posaconazole, and itraconazole revealed the need for therapeutic drug monitoring (TDM) of plasma concentrations of these antifungal agents. This need for TDM was not evident from clinical trials of these drugs. In order to establish if this requirement also applies to isavuconazole, we examined the plasma concentrations of 283 samples receiving isavuconazole in clinical practice and compared the values to those from clinical trials. The concentration distributions from real-world use and clinical trials were nearly identical (>1 μg/mL in 90% of patients)...
May 7, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29729017/risk-assessment-for-the-spread-of-candida-sp-in-dental-chair-unit-waterlines-using-molecular-techniques
#19
Wissame Mazari, Zahia Boucherit-Otmani, Imad Abdelhamid El Haci, Amine Ilahi, Kebir Boucherit
AIMS: The aim of this study was to evaluate the presence of yeasts in dental chair unit waterlines (DCUWLs) and to test their ability to form biofilms. MATERIALS AND METHODS: Eighteen dental waterlines were analysed by culture in liquid Sabouraud in order to allow the quantification and the purification of isolated yeasts from their internal surfaces. All isolates were identified by standard laboratory procedures, including CHROMagar Candida medium for orientation, commercial yeast identification system Api Candida, MALDI-TOF MS and DNA sequencing...
May 4, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29725999/clinical-pharmacokinetics-and-pharmacodynamics-of-isavuconazole
#20
REVIEW
Matthew W McCarthy, Brad Moriyama, Ruta Petraitiene, Thomas J Walsh, Vidmantas Petraitis
In March 2015, the extended-spectrum triazole antifungal isavuconazole was granted approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of invasive aspergillosis and mucormycosis. Isavuconaozle has activity against a broad range of yeasts, dimorphic fungi, and molds and is associated with fewer toxicities than voriconazole. It also has predictable pharmacokinetics in adults, fewer drug-drug interactions than many existing antifungal agents, and is available in both oral and β-cyclodextrin-free intravenous formulations...
May 4, 2018: Clinical Pharmacokinetics
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