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Lindsey J Papacostas, Andrew Henderson, Keat Choong, David Sowden
We describe a case of subcutaneous infection as a result of traumatic implantation caused by the fungus Lasiodiplodia theobromae. It was isolated in multiple swabs from the foot of an active healthy male. The fungus was identified by traditional mycology culture methods though this was slow with much time required for sporulation on only one of the agars used. Identification was confirmed by DNA sequencing. The patient was successfully treated with Voriconizole.
June 2015: Medical Mycology Case Reports
Marcia Castillo
An adolescent female received an isolated intestinal transplant. She developed severe exfoliative rejection and required complete enterectomy. The patient developed a septic hip and lung lesions with biopsy-proven Aspergillus nidulans and was treated with caspofungin, ambiosome, and voriconizole. After completing a year of treatment and extensive physical therapy, the patient requested retransplant. The case was presented to the ethics committee, which determined that the patient demonstrated understanding of the risks and benefits...
December 2013: Progress in Transplantation
Ryan B Miller, Alex C McLaren, Christine Pauken, Henry D Clarke, Ryan McLemore
BACKGROUND: Local delivery of antifungals is an important modality in managing orthopaedic fungal infection. Voriconazole is a powder antifungal suitable for addition to bone cement that is released from bone cement but the mechanical properties of antimicrobial-loaded bone cement (ALBC) made with voriconazole are unknown. QUESTIONS/PURPOSES: (1) Is voriconazole release dose-dependent? (2) Is released voriconazole active? (3) Is the loss of ALBC's compressive strength caused by voriconazole dose- and elution-dependent? METHODS: Sixty standard test cylinders were fabricated with ALBC: 300 or 600 mg voriconazole per batch eluted for 30 days in deionized water...
January 2013: Clinical Orthopaedics and related Research
Sinthumathi Natesan, Georgi Abraham, Milly Mathew, M K Lalitha, C N Srinivasan
A 29-year-old diabetic woman who had a previously failed renal allograft on maintenance hemodialysis developed sternal aspergillosis with Aspergillus terreus following a pericardiectomy. She was successfully treated with surgical debridement and a combination of antifungal agents including amphotericin B, caspofungin, and voriconizole. The diagnostic difficulties and management are discussed.
October 2007: Hemodialysis International
Matthew T Bennett, Sandra Sirrs, Janice K Yeung, Clayton A Smith
All-trans-retinoic acid (ATRA) is a new and effective treatment of acute promyelocytic leukemia. It has many side-effects, including the retinoic acid syndrome and Sweet's syndrome. There have been only nine cases of hypercalcemia associated with ATRA described in the literature. We discuss a case of hypercalcemia, which we believe was due to inhibition of cytochrome P450 function by voriconizole when used concomitantly with ATRA.
December 2005: Leukemia & Lymphoma
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