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https://www.readbyqxmd.com/read/29777928/binding-studies-of-triclocarban-with-bovine-serum-albumin-insights-from-multi-spectroscopy-and-molecular-modeling-methods
#1
Jiao Guan, Xin Yan, Yajing Zhao, Yinhe Sun, Xin Peng
The antimicrobial triclocarban (TCC) is frequently found in various personal care products (PCPs), and recent studies have demonstrated that it shows a high unintended biological activity on humans and wildlife. To evaluate the toxicity of TCC at the protein level, the effect of TCC on bovine serum albumin (BSA) has been investigated using various spectroscopic methods in combination with molecular modeling. Analysis of fluorescence quenching data of BSA revealed the formation of a ground state BSA-TCC complex with a binding constant of 2...
May 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29775817/janus-graphene-oxide-nanosheet-a-promising-additive-for-enhancement-of-polymeric-membranes-performance-prepared-via-phase-inversion
#2
Mahdi Akbari, Mojtaba Shariaty-Niassar, Takeshi Matsuura, Ahmad Fauzi Ismail
Although polymeric membranes find important role in water and waste water treatment in recent years, their fouling is still an important problem. Application of hydrophilic nanoparticles (NPs) is one of the proposed methods for reducing fouling of membranes but their dispersion and stability in hydrophobic polymer matrix is challenging. In this study Janus functionalization of the NPs was introduced as a promising technique toward achieving this goal. Polysulfone (PSf) membranes containing various concentrations of graphene oxide (GO) nanosheets and Janus graphene oxide (Janus GO) nanosheets (as additives) were fabricated via phase inversion...
May 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29775708/gelatin-alginate-coacervates-for-circumventing-proteolysis-and-probing-intermolecular-interactions-by-spr
#3
Hui-Chong Lau, Seonghee Jeong, Aeri Kim
Complex coacervates based on natural biopolymers have been explored as a protein delivery system to provide controlled release of loaded protein and circumvent its proteolytic degradation in chronic wounds. The coacervates composed of gelatin A (GA) and sodium alginate (SA) were optimized with respect to turbidity, size, zeta potential, and polydispersity index. Bovine serum albumin (BSA), a model protein, was effectively encapsulated in the coacervates, resulting in protection from trypsin digestion and controlled release...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775081/reference-values-of-left-heart-echocardiographic-dimensions-and-mass-in-male-peri-pubertal-athletes
#4
Elena Cavarretta, Francesco Maffessanti, Fabio Sperandii, Emanuele Guerra, Federico Quaranta, Antonia Nigro, Monia Minati, Marco Rebecchi, Chiara Fossati, Leonardo Calò, Fabio Pigozzi
Background Several articles have proposed reference values in healthy paediatric subjects, but none of them has evaluated a large population of healthy trained adolescents. Design The study purpose was to establish normal echocardiographic measurements of left heart (aortic root, left atrium and left ventricular dimensions and mass) in relation to age, weight, height, body mass index, body surface area and training hours in this specific population. Methods We retrospectively evaluated 2151 consecutive, healthy, peri-pubertal athletes (100% male, mean age 12...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29774185/protein-modified-ultra-small-gold-clusters-for-dual-modal-in-vivo-fluorescence-photoacoustic-imaging
#5
Duyang Gao, Yubin Liu, Yating Wang, Zhen Yuan
Background: Construction of nanoprobes for dual-modal fluorescence/photoacoustic imaging (PAI) is of great importance for the detection of disease pathology and the development of innovative therapeutics. Previously ultra-small gold clusters were designed and used as contrast agents for fluorescence imaging (FLI). However, it is not clear whether they can also serve as promising probes for PAI. In this study, protein-modified ultra-small gold clusters are produced and examined quantitatively as enhanced contrast agents for dual-modal in vivo fluorescence and PAI...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29768984/anti-cancer-study-and-whey-protein-complexation-of-new-lanthanum-iii-complex-with-the-aim-of-achieving-bioactive-anticancer-metal-based-drugs
#6
Somaye Shahraki, Fereshteh Shiri, Mostafa Heidari Majd, Somaye Dahmardeh
In this study a new lanthanum (III)-amino acid complex utilizing cysteine has been synthesized and characterized. The anticancer activities of the prepared La(III) complex against MCF-7 cell lines were studied. Results of MTT assay showed that at all three incubation times, the cytotoxic effect of prepared La(III) complex on MCF-7 breast cancer cell lines displays a time- and dose-dependent inhibitory effects. The interactions of the La(III) complex with two whey proteins (bovine serum albumin, BSA, and Bovine β-lactoglobulin, βLG) have been explored by using spectroscopic and molecular dicking methods...
May 17, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29766280/novel-insights-into-nucleoamino-acids-biomolecular-recognition-and-aggregation-studies-of-a-thymine-conjugated-l-phenyl-alanine
#7
Giovanni N Roviello
This article deals with the synthesis in solid phase and characterization of a nucleoamino amide, based on a phenylalaninamide moiety which was N-conjugated to a thymine nucleobase. In analogy to the natural nucleobase-amino acid conjugates, endowed with a wide range of biological properties, the nucleoamino amide interacts with single-stranded nucleic acids as verified in DNA- and RNA-binding assays conducted by CD and UV spectroscopies. These technologies were used to show also that this conjugate binds serum proteins altering significantly their secondary structure, as evidenced by CD and UV using BSA as a model...
May 15, 2018: Amino Acids
https://www.readbyqxmd.com/read/29763760/multispectroscopic-and-bioimaging-approach-for-the-interaction-of-rhodamine-6g-capped-gold-nanoparticles-with-bovine-serum-albumin
#8
N Manjubaashini, Mookkandi Palsamy Kesavan, Jegathalaprathaban Rajesh, T Daniel Thangadurai
Binding interaction of Bovine Serum Albumin (BSA) with newly prepared rhodamine 6G-capped gold nanoparticles (Rh6G-Au NPs) under physiological conditions (pH 7.2) was investigated by a wide range of photophysical techniques. Rh6G-Au NPs caused the static quenching of the intrinsic fluorescence of BSA that resulted from the formation of ground-state complex between BSA and Rh6G-Au NPs. The binding constant from fluorescence quenching method (Ka  = 1.04 × 104  L mol-1 ; LoD = 14.0 μM) is in accordance with apparent association constant (Kapp  = 1...
May 7, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29762622/charge-switchable-nanocapsules-with-multistage-ph-responsive-behaviours-for-enhanced-tumour-targeted-chemo-photodynamic-therapy-guided-by-nir-mr-imaging
#9
Jia Zhou, Tianliang Li, Chunlei Zhang, Junyuan Xiao, Daxiang Cui, Yingsheng Cheng
Multifunctional nanoplatforms have been developed into advanced drug delivery systems for cancer therapy. In this study, we report a charge-switchable nanocapsule with multistage pH-responsive behaviors. First, DOX-encapsulated and oleylamine-embedded hollow structures with a diameter of 132 ± 21 nm are prepared via the double emulsion method. Subsequently, the hollow structures are encompassed by Gd-DTPA-, chlorin e6 (Ce6)-, and folate (FA)-modified BSA to form tumour-targeted, dual NIR/MR imaging-guided and chemo-photodynamic therapeutic nanoplatforms...
May 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29762230/outcomes-after-infections-in-adolescents-and-young-adults-with-continuous-flow-left-ventricular-assist-devices
#10
Sharon Chen, Ryan S Cantor, Scott Auerbach, Kurt Schumacher, Christopher S Almond, Pirooz Eghtesady, Juan Alejos, Bibhuti B Das, Borah J Hong, Robert Jaquiss, James K Kirklin, Aamir Jeewa
Infections in adult ventricular assist device patients increase subsequent mortality and stroke risk. Less is known about outcomes after infections in younger patients, where diabetes and obesity, risk factors associated with poor outcomes, are less prevalent. The purpose of this study was to examine outcomes after infections in adolescents and young adults with continuous-flow left ventricular assist devices (VAD) bridged to transplant. From Pediatric Interagency Registry for Mechanically Assisted Circulatory Support and Interagency Registry for Mechanical Circulatory Support registries, we identified patients aged 12-29 years with continuous-flow VADs implanted as bridged to transplant from September 2012 to March 2016...
May 11, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29759781/sex-specific-response-to-cardiac-resynchronization-therapy-effect-of-left-ventricular-size-and-qrs-duration-in-left-bundle-branch-block
#11
Niraj Varma, Jason Lappe, Jiayan He, Mark Niebauer, Mahesh Manne, Patrick Tchou
OBJECTIVES: In this study, the authors sought to assess the impact of body and heart size on sex-specific cardiac resynchronization therapy (CRT) response rate, according to QRS duration (QRSd) as a continuum. BACKGROUND: Effects of CRT differ between sexes for any given QRSd. METHODS: New York Heart Association functional class III/IV patients with nonischemic cardiomyopathy and "true" left bundle branch block (LBBB) were evaluated...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759242/a-fluorescence-probe-acted-on-site-i-binding-for-human-serum-albumin
#12
Yuqing Xu, Meng Zhang, Boyan Li, Wen Wang, Baozhong Wang, Yushun Yang, Hailiang Zhu
A sensitive turn-on probe XYQ, has been developed for the monitoring of HSA species with highly selective and instantaneous response to real- urine sample and living cells imaging. Furthermore, the fluorescence probe acted on Site I and discrimination of HSA from BSA.
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759236/rapid-synthesis-of-three-dimensional-sulfur-doped-porous-graphene-via-solid-state-microwave-irradiation-for-protein-removal-in-plasma-sample-pretreatment
#13
Fan Li, Linyi Lu, Die Gao, Min Wang, Dandan Wang, Zhining Xia
In this work, we prepared three-dimensional sulfur-doped porous graphene (3D-SPG) via solid-state microwave method and first introduced it to plasma sample pretreatment as adsorbent for the removal of proteins. The efficient heating effect of solid-state microwave irradiation endowed the as-prepared 3D-SPG with large specific surface area, porous structures and sulfur-doped conjugated π electron surface, thus producing an outstanding adsorbent for proteins adsorption. The adsorption behavior of 3D-SPG towards proteins was explored using bovine serum albumin (BSA) as the model protein and several kinetic models and isotherm models were employed to describe the adsorption process...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759186/affinity-capture-surface-carboxyl-functionalized-mos-2-sheets-to-enhance-the-sensitivity-of-surface-plasmon-resonance-immunosensors
#14
Nan-Fu Chiu, Ting-Li Lin
The development of functionalized molybdenum disulfide (MoS2 ) has led to a new trend in the biosensing field, owing to its high sensitivity and bio-affinity characteristics with regards to the simple synthesis of carboxyl-functionalized MoS2 nanocomposites. In this study, we used monochloroacetic acid (MCA) to successfully modify carboxyl-MoS2 . The efficiency of this MCA modification method showed a higher -COOH group content of 30.1%, mainly due to chlorine atoms occupying the MoS2 sulfur vacancy to allow for the formation of a strong bonding effect...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29757700/adhesion-characteristics-of-porcine-pancreatic-islets-and-exocrine-tissue-to-coating-materials
#15
Yoshiki Nakashima, Chika Miyagi-Shiohira, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi
Since the report of the Edmonton protocol in 2000, islet transplantation has been implemented worldwide, and xenotransplantation using porcine islets has also been reported. In addition, many basic experiments using pancreatic islets and exocrine tissue after isolation have been reported. Recently, exocrine cells have been found to be essential for inducing the differentiation of pancreatic islets. Therefore, the importance of the culture conditions for pancreatic tissue when conducting experiments using pancreatic tissue is also increasing...
May 14, 2018: Islets
https://www.readbyqxmd.com/read/29757441/the-safety-and-efficacy-of-propranolol-in-reducing-the-hypermetabolic-response-in-the-pediatric-burn-population
#16
Sylvia Ojeda, Emily Blumenthal, Pamela Stevens, Clark R Andersen, Lucy Robles, David N Herndon, Walter J Meyer
Pediatric burn patients often have hypertension and tachycardia for several years post-injury. Propranolol has shown to be effective in treating the hypermetabolic state secondary to a major burn injury. This study was conducted to document a safe and effective dosing regimen for three different age groups. One hundred four burn-injured children with a 30% to 92% total body surface area burn were treated for 1 to 2 years with propranolol in the outpatient setting. Guardians of the patients were instructed on how to take and monitor the systolic blood pressure and heart rate, and document their vital signs several times a day...
May 11, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29756642/reference-values-and-correlates-of-right-atrial-volume-in-healthy-adults-by-two-dimensional-echocardiography
#17
Francesco Ferrara, Luna Gargani, Saku Ruohonen, Olga Vriz, Marco Scalese, Valentina Russo, Alberto M Marra, Anna Agnese Stanziola, Antonio Cittadini, Antonello D'Andrea, Robert Naeije, Eduardo Bossone
BACKGROUND: Right atrial (RA) volume is an important parameter in the evaluation of patients with pulmonary hypertension. Aim of this study was to define reference ranges for RA volume by two-dimensional echocardiography (2DE) in healthy adults. METHODS: A total of 596 healthy subjects [mean age 45.7 ± 14.6 years, range 18-88 years; 60.1% women] underwent a transthoracic echocardiography. In addition, a meta-analysis was performed of published studies measuring RA volume in healthy subjects, using 2DE single plane area-length (A-L) and/or method of disks (MOD) at end-systole in apical four-chamber view...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29756358/echocardiographic-parameters-to-identify-sickle-cell-patients-with-cardio-pathology
#18
Simbo Chiadika, Mary Lim-Fung, Fiorella Llanos-Chea, Astrid Serauto Canache, Wei Yang, Christina Paruthi, Xu Zhang, David D McPherson, Modupe Idowu
BACKGROUND: Sickle cell disease (SCD) affects millions of people and causes chronic hemolytic anemia leading to vasculopathies such as pulmonary hypertension and abnormalities in cardiac function that increase complications and mortality. It is therefore crucial to identify cardiac abnormalities in SCD. We aimed to assess the prevalence of echocardiographic parameters in SCD to help identify cardiopulmonary risk. METHODS: Ninety-one patients (53% male), median age of 30, body surface area (BSA) of 1...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29755218/effects-of-yoga-training-on-body-composition-and-oxidant-antioxidant-status-among-healthy-male
#19
Indranil Manna
Background: The stressful condition may cause oxidative stress, which is responsible for various diseases. Aims: The present study was designed to find out whether yoga has impact on the reduction of oxidative stress. Methods: For the present study, 95 ( n = 95) healthy male volunteers within the age group of 18-24 years were included, 35 ( n = 35) volunteers were excluded. The remaining 60 ( n = 60) volunteers were randomly divided into two groups: (a) Yoga Group ( n = 30) and (b) Control Group ( n = 30)...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29754894/lethal-area-50-percent-la50-or-standardized-mortality-ratio-smr-which-one-is-more-conclusive
#20
Ali Ahmadabadi, Majid Khadem-Rezaiyan, Alireza Sedaghat, Seyed Hasan Tavousi, Nastaran Khorrampazhouh, Atiyeh Mohsenpour, Zeinab Goudarzi, Masoumeh Hassanpour
BACKGROUND: Burn injuries impose a considerable burden on healthcare systems. It is among the top ten causes of mortality and a major cause of disability. This study aimed to calculate and compare the lethal area fifty percent (LA50) and standardized mortality ratio (SMR) in patients with burns. METHODS: This is a five-year cross-sectional study. The study population consisted of 3284 patients with acute burns who were admitted to the Burn Department of Imam Reza Hospital in Mashhad, Iran, from 2010 to 2015...
May 10, 2018: Burns: Journal of the International Society for Burn Injuries
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