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https://www.readbyqxmd.com/read/28214254/normothermia-in-arthroplasty
#1
REVIEW
Mark W Allen, David J Jacofsky
Since the initial design of surgical theaters, the thermal environment of the operating suite itself has been an area of concern and robust discussion. In the 1950s, correspondence in the British Medical Journal discussed the most suitable design for a surgeon's cap to prevent sweat from dripping onto the surgical field. These deliberations stimulated questions about the effects of sweat-provoking environments on the efficiency of the surgical team, not to mention the effects on the patient. Although these benefits translate to implant-based orthopedic surgery, they remain poorly understood and, at times, ignored...
January 17, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28213224/ordered-titanium-templates-functionalized-by-gold-films-for-biosensing-applications-towards-non-enzymatic-glucose-detection
#2
Katarzyna Grochowska, Mariusz Szkoda, Jakub Karczewski, Gerard Śliwiński, Katarzyna Siuzdak
Recently, metal nanostructures evoke much interest due to application potential in highly sensitive detectors in biochemistry and medical diagnostics. In this work we report on preparation and characteristics of thin (1-100nm) Au films deposited onto highly ordered structured titanium templates for SERS (Surface Enhanced Raman Spectroscopy) and electrochemical sensing. The Ti templates are formed by selective removal of TiO2 nanotubes out of as-anodized titanium substrate. The surface of the obtained material reproduce precisely the bottom layer of the nanotubes and consists of a uniformly distributed dimples with diameter of ~100nm...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28212277/clinical-and-molecular-evidence-of-abcc11-protein-expression-in-axillary-apocrine-glands-of-patients-with-axillary-osmidrosis
#3
Yu Toyoda, Tappei Takada, Tsuneaki Gomi, Hiroshi Nakagawa, Toshihisa Ishikawa, Hiroshi Suzuki
Accumulating evidence suggests that the risk of axillary osmidrosis is governed by a non-synonymous single nucleotide polymorphism (SNP) 538G>A in human ATP-binding cassette C11 (ABCC11) gene. However, little data are available for the expression of ABCC11 protein in human axillary apocrine glands that produce apocrine sweat-a source of odor from the armpits. To determine the effect of the non-synonymous SNP ABCC11 538G>A (G180R) on the ABCC11 in vivo, we generated transiently ABCC11-expressing transgenic mice with adenovirus vector, and examined the protein levels of each ABCC11 in the mice with immunoblotting using an anti-ABCC11 antibody we have generated in the present study...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28210628/usefulness-of-sweat-management-for-patients-with-adult-atopic-dermatitis-regardless-of-sweat-allergy-a-pilot-study
#4
Sakae Kaneko, Hiroyuki Murota, Susumu Murata, Ichiro Katayama, Eishin Morita
Background. Sweat is an aggravating factor in atopic dermatitis (AD), regardless of age. Sweat allergy may be involved in AD aggravated by sweating. Objective. We investigated whether sweat exacerbates adult AD symptoms and examined the extent of sweat allergy's involvement. Method. We asked 34 AD patients (17 men, 17 women; mean age: 27.8 years) to record the extent to which sweat aggravated their symptoms on a 10-point numerical scale. Participant responses were compared with histamine release tests (HRT)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28209466/pharmacokinetics-and-safety-of-cavosonstat-n91115-in-healthy-and-cystic-fibrosis-adults-homozygous-for-f508del-cftr
#5
Scott H Donaldson, George M Solomon, Pamela L Zeitlin, Patrick A Flume, Alicia Casey, Karen McCoy, Edith T Zemanick, Arun Mandagere, Janice M Troha, Steven A Shoemaker, James F Chmiel, Jennifer L Taylor-Cousar
BACKGROUND: Cavosonstat (N91115), an orally bioavailable inhibitor of S-nitrosoglutathione reductase, promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stability, with a mechanism of action complementary to CFTR correctors and potentiators. METHODS: A Phase I program evaluated pharmacokinetics, drug-drug interactions and safety of cavosonstat in healthy and cystic fibrosis (CF) subjects homozygous for F508del-CFTR...
February 13, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28209107/gastro-intestinal-manifestations-in-cystic-fibrosis-patients
#6
REVIEW
S Van Biervliet, C de Clercq, D Declercq, E Van Braeckel, S Van Daele, F De Baets, D De Looze
Cystic fibrosis (CF) is a life-limiting disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). This defective chloride channel, present in different organ systems such as respiratory system, gastrointestinal tract, reproductive system and sweat glands, disturbs the ion and water transport over the membranes leading to the well known CF symptoms. CF has outgrown paediatric care, as half of CF patients are currently adults. The CF gastrointestinal tract has its own particularities...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28208841/assessment-of-correlation-between-sweat-chloride-levels-and-clinical-features-of-cystic-fibrosis-patients
#7
Manzoor A Raina, Mosin S Khan, Showkat A Malik, Ab Hameed Raina, Mudassir J Makhdoomi, Javed I Bhat, Syed Mudassar
INTRODUCTION: Cystic Fibrosis (CF) is an autosomal recessive disorder and the incidence of this disease is undermined in Northern India. The distinguishable salty character of the sweat belonging to individuals suffering from CF makes sweat chloride estimation essential for diagnosis of CF disease. AIM: The aim of this prospective study was to elucidate the relationship of sweat chloride levels with clinical features and pattern of CF. MATERIALS AND METHODS: A total of 182 patients, with clinical features of CF were included in this study for quantitative measurement of sweat chloride...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28205099/evaluation-of-potentially-drug-related-patient-reported-common-symptoms-assessed-during-clinical-medication-reviews-a-cross-sectional-observational-study
#8
Tim W A Schoenmakers, Martina Teichert, Michel Wensing, Peter A G M de Smet
INTRODUCTION: Healthcare professionals tend to consider common non-alarming drug-related symptoms to be of little clinical relevance. However, such symptoms can have a substantial impact on the individual patient. Insight into patient-reported symptoms could aid pharmacists to identify improvements in medication treatment, for instance in the patient interview at the start of a clinical medication review (CMR). OBJECTIVE: The objectives of this study were to describe the numbers and types of patient-reported symptoms assessed during a CMR and to elucidate their potential association with the drugs in use...
February 15, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28204901/the-effect-of-hydration-status-on-the-measurement-of-lean-tissue-mass-by-dual-energy-x-ray-absorptiometry
#9
Clodagh M Toomey, William G McCormack, Phil Jakeman
PURPOSE: Athletes cycle between exercise and recovery. Exercise invokes changes in total body water from thermal sweating, muscle and hepatic glycogen depletion and metabolic water loss. Recovery from exercise results in rehydration, substrate repletion, and possible glycogen supercompensation. Such changes may corrupt the measurement of hydrated tissues, such as lean tissue mass (LTM), by dual-energy X-ray absorptiometry (DXA). The purpose of this study was to determine the effect of exercise and thermal dehydration and subsequent glycogen supercompensation on DXA-based measurement of body composition...
February 16, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28202694/pure-autonomic-failure-predictors-of-conversion-to-clinical-cns-involvement
#10
Wolfgang Singer, Sarah E Berini, Paola Sandroni, Robert D Fealey, Elizabeth A Coon, Mariana D Suarez, Eduardo E Benarroch, Phillip A Low
OBJECTIVE: Based on the observation that a subset of patients originally diagnosed with pure autonomic failure (PAF) eventually develops extrapyramidal or cerebellar involvement consistent with multiple system atrophy (MSA), Parkinson disease (PD), or dementia with Lewy bodies (DLB), we aimed to identify predictors of progression of PAF to more sinister synucleinopathies. METHODS: In this retrospective cohort study, we reviewed patients seen at Mayo Clinic Rochester by autonomic specialists between 2001 and 2011 and during initial evaluation diagnosed with orthostatic hypotension consistent with PAF (possible PAF)...
February 15, 2017: Neurology
https://www.readbyqxmd.com/read/28202441/effect-of-hypohydration-on-postsynaptic-cutaneous-vasodilation-and-sweating-in-healthy-men
#11
Matthew A Tucker, Ashley Six, Nicole E Moyen, Alf Z Satterfield, Matthew S Ganio
: Hypohydration decreases cutaneous vasodilation and sweating during heat stress, but it is unknown if these decrements are from postsynaptic (i.e. sweat gland/blood vessel) alterations. PURPOSE: To determine if hypohydration affects postsynaptic cutaneous vasodilation and sweating responses. METHODS: 12 healthy men participated in euhydrated (EU) and hypohydrated (HY) trials, with hypohydration induced via fluid restriction and passive heat-stress...
February 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28202022/hematologic-manifestations-of-babesiosis
#12
REVIEW
Tamer Akel, Neville Mobarakai
BACKGROUND: Babesiosis, a zoonotic parasitic infection transmitted by the Ixodes tick, has become an emerging health problem in humans that is attracting attention worldwide. Most cases of human babesiosis are reported in the United States and Europe. The disease is caused by the protozoa of the genus Babesia, which invade human erythrocytes and lyse them causing a febrile hemolytic anemia. The infection is usually asymptomatic or self-limited in the immunocompetent host, or follows a persistent, relapsing, and/or life threatening course with multi-organ failure, mainly in the splenectomized or immunosuppressed patients...
February 15, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28199715/the-relationships-of-expectancies-with-e-cigarette-use-among-hospitalized-smokers-a-prospective-longitudinal-study
#13
Peter S Hendricks, Christopher B Thorne, Sara N Lappan, Noah W Sweat, JeeWon Cheong, Rekha Ramachandran, Connie L Kohler, William C Bailey, Kathleen F Harrington
No abstract text is available yet for this article.
February 11, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28197350/disseminated-mycobacterium-interjectum-infection-with-bacteremia-hepatic-and-pulmonary-involvement-associated-with-a-long-term-catheter-infection
#14
David Sotello, D Jane Hata, Mohammed Reza, Raj Satyanarayana, Vichaya Arunthari, Wendelyn Bosch
We present a 49-year-old female with one year of intermittent fevers, chills, night sweats, and significant weight loss. Liver and lung biopsy showed evidence of a granulomatous process. Blood and liver biopsy cultures yielded growth of presumed Mycobacterium interjectum, thought to be related to a disseminated long-term central venous catheter infection. She successfully received one year of combined antimicrobial therapy after catheter removal without recurrence of disease. M. interjectum has been previously described as a cause of lymphadenitis in healthy children and associated with pulmonary disease in adults, although other localized infections have been reported...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28195994/an-internet-based-cognitive-behavioral-therapy-for-treatment-induced-menopausal-symptoms-in-breast-cancer-survivors-results-of-a-pilot-study
#15
Vera Atema, Marieke van Leeuwen, Hester S A Oldenburg, Marc van Beurden, Myra S Hunter, Neil K Aaronson
OBJECTIVE: Previous studies demonstrated that a cognitive behavioral therapy (CBT) program delivered in group sessions is effective in alleviating treatment-induced menopausal symptoms in women with breast cancer, but also that in-person CBT is inconvenient for some women and can result in low levels of program compliance. A promising, alternative approach is to use the Internet to make this form of CBT more accessible and feasible for patients. The objective of this study was to evaluate the feasibility and to generate preliminary data on the efficacy of a guided, Internet-based CBT program...
February 13, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28195970/reduction-of-physiological-strain-under-a-hot-and-humid-environment-by-a-hybrid-cooling-vest
#16
Albert P C Chan, Y Yang, Francis K W Wong, Michael C H Yam, Del P Wong, W F Song
Cooling treatment is regarded as one of good practices to provide safe training conditions to athletic trainers in the hot environment. The present study aimed to investigate whether wearing a commercial lightweight and portable hybrid cooling vest that combines air ventilation fans with frozen gel packs was an effective means to reduce participants' body heat strain. In this within-subject repeated measures study, 10 male volunteers participated in two heat-stress trials (one with the cooling vest - COOL condition, and another without - CON condition, in a randomized order) inside a climatic chamber with a controlled ambient temperature 33 °C and relative humidity (RH) 75% on an experimental day...
February 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28194692/role-of-cftr-mutation-analysis-in-the-diagnostic-algorithm-for-cystic-fibrosis
#17
Michelle Ratkiewicz, Matthew Pastore, Karen Sharrock McCoy, Rohan Thompson, Don Hayes, Shahid Ijaz Sheikh
BACKGROUND: The cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation identification is being used with increased frequency to aid in the diagnosis of cystic fibrosis (CF) in those suspected with CF. Aim of this study was to identify diagnostic outcomes when CFTR mutational analysis was used in CF diagnosis. CFTR mutational analysis results were also compared with sweat chloride results. METHODS: This study was done on all patients at our institution who had CFTR mutation analysis over a sevenyear period since August 2006...
February 14, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28194136/substance-p-and-calcitonin-gene-related-peptide-key-regulators-of-cutaneous-microbiota-homeostasis
#18
REVIEW
Awa N'Diaye, Andrei Gannesen, Valérie Borrel, Olivier Maillot, Jeremy Enault, Pierre-Jean Racine, Vladimir Plakunov, Sylvie Chevalier, Olivier Lesouhaitier, Marc G J Feuilloley
Neurohormones diffuse in sweat and epidermis leading skin bacterial microflora to be largely exposed to these host factors. Bacteria can sense a multitude of neurohormones, but their role in skin homeostasis was only investigated recently. The first study focused on substance P (SP), a neuropeptide produced in abundance by skin nerve terminals. SP is without effect on the growth of Gram-positive (Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis) and Gram-negative (Pseudomonas fluorescens) bacteria...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28194072/an-unusual-cause-of-fever-generalized-lymphadenopathy-and-eosinophilia-in-a-hcv-positive-6-year-old-boy
#19
Rajesh Kumar, Prashant Sharma, Pranab Dey, Babu Ram Thapa
A 6-year-old boy presented with a 3-month history of high-grade fever and night-sweats but without chills/rigors. On examination, he had moderate hepatosplenomegaly with multiple enlarged cervical and axillary lymph nodes. His hemogram revealed anemia and marked eosinophilia. Initial investigations were negative, except anti-HCV IgG antibodies, that were positive. Bone marrow aspirate showed a single histiocyte containing suspicious intracellular yeast-like forms. Cervical lymph node aspiration revealed a heavy load of intra- and extra-cellular Histoplasma spp...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28193033/wearable-potentiometric-chloride-sweat-sensor-the-critical-role-of-the-salt-bridge
#20
Dong-Hoon Choi, Jin Seob Kim, Garry R Cutting, Peter C Searson
The components of sweat provide an array of potential biomarkers for health and disease. Sweat chloride is of interest as a biomarker for cystic fibrosis, electrolyte metabolism disorders, electrolyte balance, and electrolyte loss during exercise. Developing wearable sensors for biomarkers in sweat is a major technological challenge. Potentiometric sensors provide a relatively simple technology for on-body sweat chloride measurement, however, equilibration between reference and test solutions has limited the time over which accurate measurements can be made...
December 20, 2016: Analytical Chemistry
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