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https://www.readbyqxmd.com/read/29136066/unsuspected-lymphomatoid-granulomatosis-in-a-patient-with-antisynthetase-syndrome
#1
Stephanie L Skala, Alexandra C Hristov, Johann E Gudjonsson, May P Chan
Clinical diagnosis of lymphomatoid granulomatosis (LYG) often is difficult, especially in patients with multiple comorbidities. We present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks' duration. Her medical history was remarkable for recent radiation therapy for recurrent breast cancer and antisynthetase syndrome complicated by interstitial lung disease and controlled with azathioprine. Computed tomography showed ground-glass opacities and nodular infiltrates in all lung lobes, raising concern for radiation pneumonitis and drug toxicity...
October 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29126226/optimizing-tuberculosis-diagnosis-in-hiv-infected-inpatients-meeting-the-criteria-of-seriously-ill-in-the-who-algorithm
#2
Rulan Griesel, Annemie Stewart, Helen van der Plas, Welile Sikhondze, Molebogeng X Rangaka, Mark P Nicol, Andre P Kengne, Marc Mendelson, Gary Maartens
BACKGROUND: The WHO algorithm for the diagnosis of tuberculosis in seriously ill HIV-infected patients lacks a firm evidence base. We aimed to develop a clinical prediction rule for the diagnosis of tuberculosis and to determine the diagnostic utility of the Xpert MTB/RIF assay in seriously ill HIV-infected patients. METHODS: We conducted a prospective study among HIV-infected inpatients with any cough duration and WHO-defined danger signs. Culture-positive tuberculosis from any site was the reference standard...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29113291/treatment-of-advanced-gastrointestinal-cancer-with-genetically-modified-autologous-mesenchymal-stem-cells-treat-me-1-a-phase-i-first-in-human-first-in-class-trial
#3
Jobst C von Einem, Sylvia Peter, Christine Günther, Hans-Dieter Volk, Gerald Grütz, Christoph Salat, Oliver Stoetzer, Peter J Nelson, Marlies Michl, Dominik P Modest, Julian W Holch, Martin Angele, Christiane Bruns, Hanno Niess, Volker Heinemann
Purpose: This phase I, first in human, first in class clinical study aimed at evaluating the safety, tolerability and efficacy of treatment with genetically modified mesenchymal stromal cells (MSC) in combination with ganciclovir (GCV). MSC_apceth_101 are genetically modified autologous MSCs used as vehicles for a cell-based gene therapy in patients with advanced gastrointestinal adenocarcinoma. Experimental design: The study design consisted of a dose-escalation 3 + 3 design...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102094/early-disseminated-lyme-disease-masquerading-as-mononucleosis-a%C3%A2-case-report
#4
Richard Tumminello, Lindsey Glaspey, Anita Bhamidipati, Patrick Sheehan, Sundip Patel
BACKGROUND: Disseminated Lyme disease can be difficult to diagnose, as it begins with nonspecific signs and symptoms, which, if not treated correctly, can lead to atrioventricular conduction blocks and meningitis. In addition, the diagnosis can be further complicated by potentially false-positive test results. CASE REPORT: We report a case of early-disseminated Lyme disease presenting with Borrelia meningitis and concomitant Lyme carditis, which was misdiagnosed as mononucleosis...
October 25, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29096334/symptom-burden-profile-in-myelofibrosis-patients-with-thrombocytopenia-lessons-and-unmet-needs
#5
Allison H Scotch, Heidi Kosiorek, Robyn Scherber, Amylou C Dueck, Stefanie Slot, Sonja Zweegman, Peter A W Te Boekhorst, Suzan Commandeur, Harry Schouten, Federico Sackmann, Ana Kerguelen Fuentes, Dolores Hernández-Maraver, Heike L Pahl, Martin Griesshammer, Frank Stegelmann, Konstanze Döhner, Thomas Lehmann, Karin Bonatz, Andreas Reiter, Francoise Boyer, Gabriel Etienne, Jean-Christophe Ianotto, Dana Ranta, Lydia Roy, Jean-Yves Cahn, Claire N Harrison, Deepti Radia, Pablo Muxi, Norman Maldonado, Carlos Besses, Francisco Cervantes, Peter L Johansson, Tiziano Barbui, Giovanni Barosi, Alessandro M Vannucchi, Chiara Paoli, Francesco Passamonti, Bjorn Andreasson, Maria L Ferrari, Alessandro Rambaldi, Jan Samuelsson, Gunnar Birgegard, Zhijian Xiao, Zefeng Xu, Yue Zhang, Xiujuan Sun, Junqing Xu, Jean-Jacques Kiladjian, Peihong Zhang, Robert Peter Gale, Ruben A Mesa, Holly L Geyer
Myelofibrosis is a myeloproliferative neoplasm associated with progressive cytopenias and high symptom burden. MF patients with thrombocytopenia have poor prognosis but the presence of thrombocytopenia frequently precludes the use of JAK2 inhibitors. In this study, we assessed quality of life and symptom burden in 418 MF patients with (n=89) and without (n=329) thrombocytopenia using prospective data from the MPN-QOL study group database, including the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and Total Symptom Score (MPN10)...
October 14, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29082266/allopurinol-induced-granulomatous-hepatitis-a-case-report-and-review-of-literature
#6
Umair Iqbal, Hafiz Umair Siddiqui, Hafsa Anwar, Ahmad Chaudhary, Abdulhadi Affan Quadri
Liver enzyme elevation is a common reason for referral to a gastroenterologist. Drugs are one of the most common reasons for asymptomatic elevation of liver enzymes. We present here a case of granulomatous hepatitis (GH) secondary to long-term use of allopurinol. An 83-year-old male with a history of chronic gout and hypertension was evaluated for elevation of liver enzymes. He denies any complaints of abdominal pain, nausea, fever, chills, weight loss, night sweats, or yellowness of skin. He denies any use of herbal medications...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29079714/tocilizumab-for-the-treatment-of-slc29a3-mutation-positive-phid-syndrome
#7
Nadia K Rafiq, Khalid Hussain, Paul A Brogan
Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) is associated with recessive mutations in SLC29A3, encoding the equilibrative nucleoside transporter hENT3 expressed in mitochondria, causing PHID and H syndromes, familial Rosai-Dorfman disease, and histiocytosis-lymphadenopathy-plus syndrome. Autoinflammation is increasingly recognized in these syndromes. We previously reported a 16-year-old girl with PHID syndrome associated with severe autoinflammation that was recalcitrant to interleukin-1 and tumor necrosis factor-α blockade...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29071584/childhood-brucellosis-in-eastern-india
#8
Devarati Dutta, Anindita Sen, Debkishore Gupta, Prabir Kuila, Debasmita Chatterjee, Sugat Sanyal, Satadal Das
OBJECTIVE: To investigate the presence of childhood brucellosis presenting as PUO (pyrexia of unknown origin) cases in Eastern zone of India. METHODS: Blood samples were collected from PUO patients aged ≤18 y. The main diagnostic tools were STAT, RBPT, ELISA- IgM, IgG and PCR. Although mainly PUO cases were selected for the study, other associated clinical manifestations were also noted. RESULTS: The findings revealed significantly higher percentage of infection in female children (14...
October 26, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29066920/study-of-the-clinical-and-functional-characteristics-of-asthmatic-children-with-obstructive-sleep-apnea
#9
Yen Nguyen-Hoang, Thuy Nguyen-Thi-Dieu, Sy Duong-Quy
BACKGROUND AND OBJECTIVE: The obstructive sleep apnea (OSA) is a common respiratory disorder in children, especially those at preschool and school ages. This study aimed to describe the characteristics of asthmatic children with OSA and the symptoms for a high risk of OSA. SUBJECTS AND METHODS: It was a prospective and descriptive study. The data of asthmatic children including medical history, clinical examination, blood tests, spirometry, exhaled nitric oxide (NO), and respiratory polygraphy were registered for analyses...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29020319/tuberculosis-case-finding-with-combined-rapid-point-of-care-assays-xpert%C3%A2-mtb-rif-and-lam-in-hiv-positive-individuals-starting-antiretroviral-treatment-in-mozambique
#10
Marco Floridia, Fausto Ciccacci, Mauro Andreotti, Archa Hassane, Zita Sidumo, Nurja A Magid, Horacio Sotomane, Muhlavasse David, Elsa Mutemba, Junia Cebola, Remigio Josè Mugunhe, Fabio Riccardi, Maria Cristina Marazzi, Marina Giuliano, Leonardo Palombi, Sandro Mancinelli
Background: Tuberculosis (TB) is a major health concern in several countries, and effective diagnostic algorithms in HIV+ patients are urgently needed. Methods: At prescription of antiretroviral therapy (ART), all patients of three Mozambican health centres were screened for TB, with a combined approach: the WHO 4-symptom screening (fever, cough, night sweats, weight loss) (WHO-4SS), a rapid test detecting mycobacterial lipoarabinomannan in urine (LAM), and a molecular assay on sputum (Xpert® MTB/RIF, repeated if first result was negative)...
July 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28993352/delays-in-diagnosis-and-treatment-of-extrapulmonary-tuberculosis-in-guatemala
#11
Pooja Ajay Shah, Merida Coj, Peter Rohloff
A 23-year-old indigenous Guatemalan man presented in 2016 to our clinic in Sololá, Guatemala, with 10 months of recurrent neck swelling, fevers, night sweats and weight loss. Previously, he had sought care in three different medical settings, including a private physician-run clinic, a tertiary private cancer treatment centre and, finally, a rural government health post. With assistance from our institution's accompaniment staff, the patient was admitted to a public tertiary care hospital for work-up. Rifampin-susceptible tuberculosis was diagnosed, and appropriate treatment was begun...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28955147/diagnosis-and-treatment-of-rash-fever-with-anxiety
#12
Yueyun Zhu
A patient was admitted to our hospital with irregular rash, fever, fatigue, night sweats, and insomnia. The patient's condition showed no improvements with routine testing and treatments. In this paper, a successful treatment is presented for future therapeutic reference of this type of patient.
August 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28953683/classic-hodgkin-lymphoma-in-pelvis-a-case-report-highlights-diagnosis-and-treatment-challenges
#13
Fan Tang, Li Min, Yunxia Ye, Bo Tang, Yong Zhou, Wenli Zhang, Chongqi Tu
RATIONALE: Classic Hodgkin lymphoma with pelvic involvement is a rare entity. Diagnosis and treatment for such an uncommon disease are challenging. Here we report a special case of classic Hodgkin lymphoma in pelvis. PATIENT CONCERNS: A 20-year-old woman was admitted to our department due to left hip symptoms. The patient reported a history of drenching night sweats, low-grade fever, pruritic rash on the body, and an almost 15% weight loss during the previous 3 months...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28942834/brucellosis-a-lymphoma-like-presentation
#14
Marcel Massoud, Fouad Kerbage, Leony Antoun, Ribal Merhi, Souheil Hallit, Rabih Hallit
Brucellosis is one of the most common zoonotic infections worldwide caused by gram negative bacilli of the genus Brucella. It is transmitted to humans by contact with infected animals or derived food products such as unpasteurized milk. Brucellosis' clinical presentation varies widely from multi-systemic involvement to asymptomatic infection. We present the case of a 52-year-old Lebanese male who was admitted to our hospital with a 3-week history of fever (up to 40 °C), chills, night sweats and abdominal pain...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28941855/diagnosis-of-clinically-suspected-and-unsuspected-tubercular-lymphadenopathy-by-cytology-culture-and-smear-microscopy
#15
Vivek Gupta, Arvind Bhake
BACKGROUND: Tubercular lymphadenopathy (TBLN) accounts for 20-40% cases of extrapulmonary tuberculosis. But the common presenting symptoms of tuberculosis like fever, cough, weight loss, fatigue, and night sweats are not always associated with tuberculosis lymphadenopathy, thereby, making its diagnosis difficult. Our aim was to study if Fine Needle Aspiration Cytology (FNAC) combined with Zeihl Neelsen stain and culture for Mycobacterium tuberculosis bacilli could improve the diagnostic accuracy in patients clinically suspected and unsuspected for tubercular lymphadenitis...
October 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28933968/influence-of-menopausal-symptoms-on-perceived-work-ability-among-women-in-a-nigerian-university
#16
A O Olajubu, A E Olowokere, D O Amujo, T O Olajubu
OBJECTIVES: This study investigated the menopausal symptoms experienced by women of menopausal age in Ekiti State, Nigeria and the influence on their perceived work ability. METHOD: A descriptive cross-sectional research design was employed and the study was conducted among 200 working-class women aged 45 years and above who had experienced at least 12 continuous months of amenorrhea in Ekiti State University, Ado Ekiti. A semi-structured questionnaire adapted from the Greene Climacteric Scale and the work ability index was used to assess menopausal symptoms and work ability, respectively...
September 21, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28931157/is-nocturnal-foraging-in-a-tropical-bee-an-escape-from-interference-competition
#17
Adam R Smith, Shannon M Kitchen, Ryan M Toney, Christian Ziegler
Temporal niche partitioning may result from interference competition if animals shift their activity patterns to avoid aggressive competitors. If doing so also shifts food sources, it is difficult to distinguish the effects of interference and consumptive competition in selecting for temporal niche shift. Bees compete for pollen and nectar from flowers through both interference and consumptive competition, and some species of bees have evolved nocturnality. Here, we use tropical forest canopy towers to observe bees (the night-flying sweat bees Megalopta genalis and M...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28923180/menopause-in-latin-america-symptoms-attitudes-treatments-and-future-directions-in-costa-rica
#18
REVIEW
T D Locklear, B J Doyle, A L Perez, S M Wicks, G B Mahady
Similar to their US counterparts, Costa Rican women enter menopause at ∼50 years of age, have similar symptoms, including hot flashes and night sweats, as well as an overall negative attitude toward the menopausal transition. One study of rural women in Monteverde reported that women knew little about the menopausal transition, as the subject was not discussed. Similar to other Latin American women, the use of hormone therapy by Costa Rican women is low and instead they use alternative therapies, including massage, dietary changes and herbal medicines...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28906499/-incomplete-poems-syndrome-with-multicentric-castleman-s-disease
#19
P González de la Aleja, M García-Navarro, R Sánchez-Rodríguez, J M Ramos-Rincón
Castleman's disease (CD) is an atypical lymphoproliferative disorder of unknown cause, characterized by non-clonal nodal hyperplastic growth. Two forms of clinical presentation are currently recognized, one localized and the other multicentric, and four histopathologic variants. It is characterized by generalized lymphadenopathy, hepatosplenomegaly, fever and night sweats. CD may present severe pancytopenia, multi-organ failure, lymphoma evolution and it can sometimes be associated with paraneoplastic syndromes such as POEMS syndrome...
September 14, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28864556/massive-splenomegaly-due-to-concurrent-primary-epstein-barr-virus-and-cytomegalovirus-infection-in-a-patient-on-adalimumab
#20
Barathy Rani Ramasamy, Patrick Charles, Douglas Johnson, Albert Frauman
A 32-year-old man who was receiving adalimumab for seronegative rheumatoid arthritis presented with a 4-week history of fever, night sweats, fatigue, myalgias and diarrhoea. On examination, he had obvious splenomegaly but no lymphadenopathy or pharyngitis. Full blood count revealed mild neutropenia and significant lymphocytosis, with a blood film showing atypical lymphocytes. Liver function tests were mildly deranged with a mixed hepatitic and obstructive pattern. Ultrasound confirmed massive splenomegaly with a span of 21 cm in the long axis...
September 1, 2017: BMJ Case Reports
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