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https://www.readbyqxmd.com/read/29042582/portable-biosensor-for-monitoring-cortisol-in-low-volume-perspired-human-sweat
#1
David Kinnamon, Ramesh Ghanta, Kai-Chun Lin, Sriram Muthukumar, Shalini Prasad
A non-faradaic label-free cortisol biosensor was demonstrated using MoS2 nanosheets integrated into a nanoporous flexible electrode system. Low volume (1-5 μL) sensing was achieved through use of a novel sensor stack design comprised of vertically aligned metal electrodes confining semi-conductive MoS2 nanosheets. The MoS2 nanosheets were surface functionalized with cortisol antibodies towards developing an affinity biosensor specific to the physiological relevant range of cortisol (8.16 to 141.7 ng/mL) in perspired human sweat...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042177/antibiotic-exposure-and-interpersonal-variance-mask-the-effect-of-ivacaftor-on-respiratory-microbiota-composition
#2
Anton Y Peleg, Jocelyn Choo, Katherine Langan, Deirdre Edgeworth, Dominic Keating, John Wilson, Geraint B Rogers, Tom Kotsimbos
BACKGROUND: G551D is a class III mutation of the cystic fibrosis transmembrane regulator (CFTR) that results in impaired chloride channel function in cystic fibrosis (CF). Ivacaftor, a CFTR-potentiating agent improves sweat chloride, weight, lung function, and pulmonary exacerbation rate in CF patients with G551D mutations, but its effect on the airway microbiome remains poorly characterised. METHODS: Twenty CF patients with at least one G551D mutation from a single centre were recruited to a 4month double-blind, placebo-controlled, crossover study of ivacaftor with 28days of active treatment...
October 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29040221/thermoeffector-responses-at-a-fixed-rate-of-heat-production-in-heart-failure-patients
#3
Bryce N Balmain, Ollie Jay, Norman R Morris, Kenji Shiino, Glenn M Stewart, Rohan Jayasinghe, Jonathan Chan, Surendran Sabapathy
PURPOSE: Heart failure (HF) patients appear to exhibit altered thermoregulatory responses during exercise in the heat. However, the extent to which these responses are altered due to physiological impairments independently of biophysical factors associated with differences in metabolic heat production (Hprod), evaporative heat balance requirements (Ereq) and/or body size, is presently unclear. Therefore, we examined thermoregulatory responses in 10 HF and 10 age-matched controls (CON) similar in body size during exercise at a fixed rate of Hprod, and therefore Ereq in a 30°C environment...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29040085/sources-of-pharmaceuticals-and-personal-care-products-in-swimming-pools
#4
Laura M Suppes, Ching-Hua Huang, Wan-Ning Lee, Kyle J Brockman
Pharmaceuticals and personal care products (PPCPs) in swimming pool water are hypothesized to originate from fill water and anthropogenic sources like urine, sweat, swimwear and body surfaces. However, research exploring PPCP origins in pools is lacking. This research investigates PPCP sources at 31 swimming pools. Pool water was analyzed for 24 representative PPCPs using advanced liquid chromatography-mass spectrometry techniques. Fill water was analyzed as a contamination source and to determine if swimmers introduce PPCPs to pools...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29039233/the-relationships-of-classic-psychedelic-use-with-criminal-behavior-in-the-united-states-adult-population
#5
Peter S Hendricks, Michael Scott Crawford, Karen L Cropsey, Heith Copes, N Wiles Sweat, Zach Walsh, Gregory Pavela
Criminal behavior exacts a large toll on society and is resistant to intervention. Some evidence suggests classic psychedelics may inhibit criminal behavior, but the extent of these effects has not been comprehensively explored. In this study, we tested the relationships of classic psychedelic use and psilocybin use per se with criminal behavior among over 480,000 United States adult respondents pooled from the last 13 available years of the National Survey on Drug Use and Health (2002 through 2014) while controlling for numerous covariates...
October 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29039047/the-expression-pattern-of-keratin-24-in-tissue-engineered-dermo-epidermal-human-skin-substitutes-in-an-in-vivo-model
#6
Agnes S Klar, Katarzyna Michalak, Sophie Böttcher-Haberzeth, Ernst Reichmann, Martin Meuli, Thomas Biedermann
AIMS AND OBJECTIVES: The use of autologous tissue-engineered skin substitutes is a promising approach to cover large skin defects in patients. Preclinical investigation is pivotal to test and improve the quality of these bio-engineered substitutes. In the skin, the epidermis, formed mainly by keratinocytes, provides the first physical barrier protecting from the environment. Proper keratinocyte differentiation and, thus, formation of a stratified epidermis is essential for this function...
October 16, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29037527/cork-study-in-cf-sustained-improvements-in-ultra-low-dose-chest-ct-scores-post-cftr-modulation-with-ivacaftor
#7
Nicola J Ronan, Gisli G Einarsson, Maria Twomey, Denver Mooney, David Mullane, Muireann NiChroinin, Grace O'Callaghan, Fergus Shanahan, Desmond M Murphy, Owen J O'Connor, Cathy A Shortt, Michael M Tunney, Joseph A Eustace, Michael M Maher, J Stuart Elborn, Barry J Plant
BACKGROUND: Ivacaftor produces significant clinical benefit in patients with cystic fibrosis (CF) with the G551D mutation. Prevalence of this mutation at Cork CF Centre is 23%. This study assessed the impact of CFTR modulation on multiple modalities of patient assessment. METHODS: Thirty three patients with the G551D mutation were assessed at baseline and prospectively three monthly for one year post initiation of ivacaftor. Change in ultra-low dose chest CT, blood inflammatory mediators, and sputum microbiome were assessed...
October 13, 2017: Chest
https://www.readbyqxmd.com/read/29037399/comparison-of-heat-strain-recovery-in-different-anti-heat-stress-clothing-ensembles-after-work-to-exhaustion
#8
Yijie Zhao, Wen Yi, Albert P C Chan, Daniel W M Chan
A hot environment combined with physically demanding tasks can subject workers to a higher risk of heat stress. A series of regulations and guidelines have been proposed to design appropriate anti-heat stress work uniform to reduce body heat strain. The present study aimed to examine heat strain recovery in different anti-heat stress clothing ensembles after work to exhaustion in the heat. 10 healthy males performed intermittent treadmill running/walking to exhaustion, followed by 30min passive recovery sitting in a climatic chamber, which simulated the hot and humid outdoor environment (34°C temperature, 60% relative humidity, 0...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29037398/thermoregulation-of-male-sheep-of-indigenous-or-exotic-breeds-in-a-tropical-environment
#9
Messy Hannear de Andrade Pantoja, Sérgio Novita Esteves, Manuel Antonio Chagas Jacinto, José Ricardo Macedo Pezzopane, Cláudia Cristina Paro de Paz, Jamile Andréa Rodrigues da Silva, José de Brito Lourenço Junior, Felipe Zandonadi Brandão, Ana Beatriz Bossois Moura, Narian Romanello, Daniela Botta, Alexandre Rossetto Garcia
Climate change has intensified the frequency of heat waves in the world, thereby exposing farm animals to stressful conditions. For better productive performance it is important to identify the most resilient genotypes. Thus, our objective was to evaluate the thermoregulatory responses of rams of tropical indigenous (Morada Nova and Santa Inês) and exotic breeds (Dorper and Texel), by monitoring the environmental and physiological indicators related to heat tolerance. The experiment was carried out in a tropical climate region (Cwa), in Brazil, for twelve months, which comprised spring, summer, autumn and winter...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29036002/multimodal-imaging-in-klippel-tr%C3%A3-naunay-weber-syndrome-clinical-photography-computed-tomoangiography-infrared-thermography-and-99mtc-phytate-lymphoscintigraphy
#10
Su Wan Kim, Heesung Song
We report the case of a 19-year-old man who presented with a 12-year history of progressive fatigue, feeling hot, excessive sweating, and numbness in the left arm. He had undergone multimodal imaging and was diagnosed as having Klippel-Trénaunay-Weber syndrome (KTWS). This is a rare congenital disease, defined by combinations of nevus flammeus, venous and lymphatic malformation, and hypertrophy of the affected limbs. Lower extremities are affected mostly. Conventional modalities for evaluating KTWS are ultrasonography, CT, MRI, lymphoscintigraphy, and angiography...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29032948/anxiety-and-pain-related-to-mandibular-block-injections-comparison-of-self-reported-measures-and-physiological-response
#11
Jacco G Tuk, Jerome A Lindeboom, Linda Hoogendoorn, Byron W Taylor, Arjen J van Wijk
OBJECTIVE: The aim of this study was to determine whether patients with a pain score ≥7 (high pain group) after a mandibular block injection had a higher physiologic response compared with patients with scores <7 (low pain group). STUDY DESIGN: Before oral surgery, patients (n = 66) filled out questionnaires to measure anxiety and expected pain. The questionnaires also assessed patients' experiences with dental injections and dental anxiety, as well as their emotional state and intensity of anxiety...
September 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29028127/pure-mucinous-colloid-adenocarcinoma-of-the-conjunctiva
#12
Valentina Logunova, Olayemi Sokumbi
Mucinous carcinomas of the periorbital area are very rare malignant tumors and can be primary or secondary to metastasis. Primary mucinous carcinomas of the eyelid include, most commonly, primary cutaneous mucinous carcinoma with endocrine mucin-producing sweat gland carcinoma being a remote second.[1,2,3,4] To our knowledge, primary mucinous carcinomas of conjunctiva or lacrimal gland elements have not been described in the literature.[5,6] Metastatic carcinoma from visceral sites should also be considered in the differential diagnosis...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29027680/determination-of-thiocyanate-as-a-biomarker-of-tobacco-smoke-constituents-in-selected-biological-materials-of-human-origin
#13
Sylwia Narkowicz, Ewa Jaszczak, Żaneta Polkowska, Bogumiła Kiełbratowska, Alicja Kotłowska, Jacek Namieśnik
In order to protect human health, it is necessary to biomonitor toxic substances originating from tobacco smoke in biological materials sampled from the persons with different exposures to tobacco smoke constituents. Thiocyanate anion is a biomarker of exposure to tobacco smoke components which is characterized by a relatively long half-life in the human body, i.e. 6 days. In this work, we present the results of thiocyanate determinations performed on the samples of placenta, meconium, saliva, breast milk, sweat and blood...
October 13, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29026613/a-case-of-generalized-argyria-presenting-with-muscle-weakness
#14
Inha Jung, Eun-Jeong Joo, Byung Seong Suh, Cheol-Bae Ham, Ji-Min Han, You-Gyung Kim, Joon-Sup Yeom, Ju-Yeon Choi, Ji-Hye Park
BACKGROUND: Argyria is a rare irreversible cutaneous pigmentation disorder caused by prolonged exposure to silver. Herein, we report a case of generalized argyria that developed after chronic ingestion of soluble silver-nano particles and presented with muscle weakness. CASE PRESENTATION: A 74-year-old woman visited our emergency room, complaining of fever and mental deterioration. She was diagnosed with acute pyelonephritis and recovered after antibiotic therapy...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29024370/classification-of-heat-related-illness-symptoms-among-florida-farmworkers
#15
Abby D Mutic, Jacqueline M Mix, Lisa Elon, Nathan J Mutic, Jeannie Economos, Joan Flocks, Antonio J Tovar-Aguilar, Linda A McCauley
BACKGROUND: Farmworkers working in hot and humid environments have an increased risk for heat-related illness (HRI) if their thermoregulatory capabilities are overwhelmed. The manifestation of heat-related symptoms can escalate into life-threatening events. Increasing ambient air temperatures resulting from climate change will only exacerbate HRI in vulnerable populations. We characterize HRI symptoms experienced by farmworkers in three Florida communities. METHODS: A total of 198 farmworkers enrolled in 2015-2016 were asked to recall if they experienced seven HRI symptoms during the previous work week...
October 12, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/29023952/pharmacokinetics-and-electrophysiological-effects-of-sotalol-hydrochloride-in-horses
#16
B Broux, D De Clercq, A Decloedt, L Vera, M Devreese, R Gehring, S Croubels, G van Loon
BACKGROUND: Arrhythmias in horses may require long term anti-arrhythmic therapy. Unfortunately, oral anti-arrhythmic drugs for use in horses are currently scarce. In human patients and small animals, sotalol, a β-blocker with class III anti-arrhythmic properties, is often used for long-term treatment. OBJECTIVES: To determine the pharmacokinetics of sotalol at multiple oral dosages in unfasted horses, as well as the effects on electro- and echocardiographic measurements, right atrial and ventricular monophasic action potential (MAP) and effective refractory period (ERP)...
October 10, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29023279/syncope-episodes-and-blood-flow-restriction-training
#17
Juan Martín-Hernández, Alejandro Santos-Lozano, Carl Foster, Alejandro Lucia
The combination of low-load resistance training [or more recently, neuromuscular electrical stimulation (NMES)] with a moderate local blood flow restriction (BFR) is becoming a widespread training and rehabilitation method. Scientific data indicate the overall safety of BFR, at least in healthy young people. However, it has been associated with side effects, usually minor, and further research is warranted regarding the safety and efficacy of this technique, especially in clinical populations. We found 3 syncope/presyncopal episodes among 21 healthy people (9 men), all occurring in men and during familiarization sessions (in which BFR was applied alone) but not thereafter (BFR sessions combined with NMES): 1 subject experienced a brief syncope and 2 other subjects exhibited presyncopal symptoms (sweating, lightheadedness, and pallor)...
October 6, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29021192/orderly-recruitment-of-thermoeffectors-in-resting-humans
#18
Zachary J Schlader, James R Sackett, Suman Sarker, Blair D Johnson
The recruitment of thermoeffectors, including thermoregulatory behavior, relative to changes in body temperature has not been quantified in humans. We tested the hypothesis that changes in skin blood flow, behavior, and sweating or metabolic rate are initiated with increasing changes in mean skin temperature (Tskin) in resting humans. While wearing a water perfused suit, twelve healthy young adults underwent heat (HEAT) and cold (COLD) stress that induced gradual changes in Tskin Subjects controlled the temperature of their dorsal neck to their perceived thermal comfort...
October 11, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29020717/ulnar-nerve-injury-on-removal-of-a-contraceptive-implant
#19
Eva E O'Grady, Dominic M Power
The close proximity of contraceptive implant placement to the course of the ulnar nerve can result in injury. Several factors have been implicated in this complication including: low BMI, erroneous placement of the implant, implantation over the brachial groove, and migration of the implant from its original insertion. Clinicians should familiarise themselves with the vulnerable neurovascular structures in the area and refer promptly to a specialist if any neurological symptoms develop during placement or removal of these devices...
December 2016: Practitioner
https://www.readbyqxmd.com/read/29020319/tuberculosis-case-finding-with-combined-rapid-point-of-care-assays-xpert%C3%A2-mtb-rif-and-lam-in-hiv-positive-individuals-starting-antiretroviral-treatment-in-mozambique
#20
Marco Floridia, Fausto Ciccacci, Mauro Andreotti, Archa Hassane, Zita Sidumo, Nurja A Magid, Horacio Sotomane, Muhlavasse David, Elsa Mutemba, Junia Cebola, Remigio Josè Mugunhe, Fabio Riccardi, Maria Cristina Marazzi, Marina Giuliano, Leonardo Palombi, Sandro Mancinelli
Background: Tuberculosis (TB) is a major health concern in several countries, and effective diagnostic algorithms in HIV+ patients are urgently needed. Methods: At prescription of antiretroviral therapy (ART), all patients of three Mozambican health centres were screened for TB, with a combined approach: the WHO 4-symptom screening (fever, cough, night sweats, weight loss) (WHO-4SS), a rapid test detecting mycobacterial lipoarabinomannan in urine (LAM), and a molecular assay on sputum (Xpert® MTB/RIF, repeated if first result was negative)...
July 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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