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Marki E Klapperich, Brittany A Buhalog, Molly A Hinshaw
A male in his twenties presented with a tender finger nodule that had been present for 3 months. Histopathological examination revealed a dermis with nodules of necrotic, athypical epithelaia cells with high nuclear to cytoplasmic ratios. Glandular formation was present with lumens lined by columnar epithelium, consistent with digital papillary adenocarcinoma. Digital papilary adenocarcinoma is a rare malignant adnexal tumor arising from sweat glands and requires further work-up.
April 15, 2018: Dermatology Online Journal
Glenmore Lasam, Marcelina Lasam
A case of a 73-year-old woman with a history of von Recklinghausen disease (neurofibromatosis type 1) who presented initially with a gradual onset of shortness of breath and lightheadedness with no associated fever, chills, angina, palpitations, cough, weight loss, night sweats, nausea, vomiting, or constipation. She was found to be severely bradycardic and in third degree atrioventricular block by her primary care physician. She was admitted in the hospital because of intermittent bouts of lightheadedness and progression of the shortness of breath...
June 2018: Cardiology Research
Bibai Ren, Glenmore Lasam
We report a case of a 56-year-old man who presented initially with a sudden onset of right-sided facial droop and weakness, aphasia, and confusion with no associated fever, chills, syncope, fatigue, weight loss, night sweats, nausea, vomiting, diarrhea, odontalgia, palpitations, cough, or dyspnea. Code stroke was called and the patient received tissue plasminogen activator (tPA) with subsequent resolution of his symptoms. Cranial magnetic resonance imaging showed left frontal punctate cortical restricted diffusion consistent with subacute to acute infarction...
June 2018: Cardiology Research
Anna Szeliga, Adam Czyzyk, Agnieszka Podfigurna, Andrea R Genazzani, Alessandro D Genazzani, Blazej Meczekalski
Women during perimenopausal period experience a range of symptoms, which interfere with physical, sexual, and social life. About 65-75% of symptoms connected with postmenopausal period are vasomotor symptoms (VMS), such as hot flushes and night sweats. Hot flushes are subjective sensation of heat associated with cutaneous vasodilatation and drop in core temperature. It is suspected that VMS are strongly correlated with pulsatile oversecretion of gonadotropin-releasing hormone (GnRH) and subsequently luteinizing hormone (LH)...
June 14, 2018: Gynecological Endocrinology
Yuka Koyama, Takao Mukuda, Sawako Hamasaki, Hironobu Nakane, Toshiyuki Kaidoh
Angiotensin II (Ang II) synthesized in response to body fluid loss caused by actions such as sweating and breathing is today considered as one of the essential factors for promoting hippocamal neurogenesis. Because heat-stimuli, along with exercise, increases systemic levels of Ang II, the effects of short-term heat exposure on hippocampal neurogenesis were examined in adult male rats. When rats were exposed daily to a 1 h heat treatment (36.0 ± 0.1°C) during a 7 d experimental period, the number of doublecortin-immunoreactive newborn cells in the hippocampal dentate gyrus was increased approximately 1...
June 11, 2018: Neuroscience
R Morris-Jones
No abstract text is available yet for this article.
June 2018: British Journal of Dermatology
N Yoshioka, K Kurata, T Takahashi, M Ariizumi, T Mori, H Fujisawa, N Kameyama, Y Okuyama
Body odor is mainly caused by secreted sweat. Although sweat is almost odorless immediately after secretion, decomposition or denaturation of components contained in sweat by bacteria on the skin surface contributes to unpleasant body odor. Body odor is due to various substances and aldehydes are primarily detected in body odor [1-4]. This article is protected by copyright. All rights reserved.
June 13, 2018: International Journal of Cosmetic Science
Hima Gopinath, Ramalingam Karthiga, Kaliaperumal Karthikeyan
BACKGROUND: The role of sweat gland in inflammation has not received sufficient attention. The thermal stress during the summer months in tropical areas provides an opportunity to study the morphological patterns of inflammation produced primarily by the sweat gland. AIM: To collect clinical data on sweat-induced dermatitis during the summer months. METHODS: A hospital-based descriptive cross-sectional study was done during the hot and humid summer months of April to June in a tertiary care institute in Puducherry...
June 12, 2018: International Journal of Dermatology
Y Xiaoling, W Chao, W Wenming, L Feng, J Hongzhong
BACKGROUND: Palmoplantar pustulosis (PPP) is a refractory, nonbacterial impetigo confined to the palms and soles. Its pathogenesis is still obscure, but it may be associated with the large eccrine sweat glands and pores of palmoplantar skin. PPP is considered to be a localized pustular psoriasis. Interleukin (IL)-8, IL-36γ and IL-36Ra play important roles in the pathogenesis of pustular psoriasis, but their role in PPP is unclear. AIM: To evaluate IL-8, IL-36γ and IL-36Ra expression in PPP, and their relationship with acrosyringia and pustule formation...
June 12, 2018: Clinical and Experimental Dermatology
Chihiro Endo, Todd A Johnson, Ryoko Morino, Kazuyuki Nakazono, Shigeo Kamitsuji, Masanori Akita, Maiko Kawajiri, Tatsuya Yamasaki, Azusa Kami, Yuria Hoshi, Asami Tada, Kenichi Ishikawa, Maaya Hine, Miki Kobayashi, Nami Kurume, Yuichiro Tsunemi, Naoyuki Kamatani, Makoto Kawashima
Skin trait variation impacts quality-of-life, especially for females from the viewpoint of beauty. To investigate genetic variation related to these traits, we conducted a GWAS of various skin phenotypes in 11,311 Japanese women and identified associations for age-spots, freckles, double eyelids, straight/curly hair, eyebrow thickness, hairiness, and sweating. In silico annotation with RoadMap Epigenomics epigenetic state maps and colocalization analysis of GWAS and GTEx Project eQTL signals provided information about tissue specificity, candidate causal variants, and functional target genes...
June 12, 2018: Scientific Reports
Bence Kővári, Lajos Kocsis, Erika Varga, Gábor Cserni
Encouraged by our previous finding of growth hormone-releasing hormone receptor (GHRH-R) expression in metaplastic and neoplastic apocrine breast epithelium, we examined a small series of skin adnexal tumours with various degrees of apocrine (oxyphilic) differentiation, as well as normal axillary and anogenital apocrine sweat glands, for the expression of GHRH-R. Sections of formalin-fixed paraffin-embedded tissue blocks were immunostained for gross cystic disease fluid protein-15 (GCDFP-15) and androgen receptor (AR), to prove apocrine differentiation and correlate it with areas of GHRH-R expression...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Y Poorun, M Z Dauhoo, M Bessafi, M K Elahee, A Gopaul, A Khoodaruth
This work presents the development and physical analysis of a sweat transport model that couples the fluctuations in air and vapour concentrations, and temperature, in a one-dimensional porous clothing assembly. The clothing is exposed to inherent time-varying conditions due to variations in the body temperature and ambient conditions. These fluctuations are governed by a coupled system of nonlinear relaxation-transport-diffusion PDEs of Petrovskii parabolic type. A condition for the well-posedness of the resulting system of equations is derived...
May 2018: Royal Society Open Science
Yi-Yu Peng, Hui-Tao Jing, Lan Luan, Ying-Ying Tu
OBJECTIVE: To observe the clinical efficacy of joint application of electroacupuncture (EA), acupointinjection and fire-needle in the treatment of menopausal syndrome (MS) women. METHODS: One hundred MS patients were randomized into control group and combined treatment group ( n =50 patients in each). The combined treatment group was treated by joint application of EA, acupoint-injection and fire-needle stimulation, and the control group treated by EA stimulation alone...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Karan Agrawal, Lauren A Hassoun, Negar Foolad, Kamil Borkowski, Theresa L Pedersen, Raja K Sivamani, John W Newman
Skin disease alters cutaneous lipid mediator metabolism, and if skin secretions contain evidence of these changes, they may constitute useful clinical matrices with low associated subject burden. The influences of skin diseases on sebum lipid mediators are understudied. Here, sebum oxylipins, endocannabinoids, sphingolipids, and fatty acids were quantified from the non-lesional bilateral cheeks of subjects with and without quiescent atopic dermatitis (AD) using LC-MS/MS and GC-MS. AD decreased C36 [NS] and [NdS] ceramide concentrations...
July 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
Margaret Rosenfeld, Claire E Wainwright, Mark Higgins, Linda T Wang, Charlotte McKee, Daniel Campbell, Simon Tian, Jennifer Schneider, Steve Cunningham, Jane C Davies
BACKGROUND: Ivacaftor is generally safe and effective in patients aged 2 years and older who have cystic fibrosis and specific CFTR mutations. We assessed its use in children aged 12 to <24 months. METHODS: The ARRIVAL study is a phase 3, single-arm, two-part, multicentre study. Eligible children were aged 12 to <24 months at enrolment and had a confirmed diagnosis of cystic fibrosis and a CFTR gating mutation on at least one allele and could participate in one or both parts of the study...
June 6, 2018: Lancet Respiratory Medicine
Ehab F Salim, Gaser A Ali
BACKGROUND: There are different techniques for thoracoscopic sympathectomy for management of primary hyperhidrosis. Each technique has the advantage of giving good surgical results but may cause complications which depend on the level of sympathectomy used in each technique. METHODS: From October 2012 to August 2016, a total number of 120 patients (of primary palmar and axillary hyperhidrosis) were enrolled in this prospective randomized study. Patients were randomized preoperatively and divided into two groups: group A (underwent T2, T3, and T4 sympathectomy), and group B (underwent T3 and T4 sympathectomy) with one year of follow-up...
June 7, 2018: Annals of Thoracic Surgery
Leah C Horslen, Candice L Wilshire, Brian E Louie, Eric Vallières
BACKGROUND: Endoscopic thoracic sympathectomy (ETS) is the gold standard treatment for primary hyperhidrosis, with excellent short-term results. The potential for adverse effects, particularly compensatory sweating (CS), may affect long-term satisfaction. In this retrospective review we aimed to examine the long-term results, and quality of life (QOL) following ETS in the management of primary, dominantly palmar hyperhidrosis from a single institution. METHODS: A review of patients who had undergone ETS for primary palmar or axillary hyperhidrosis between 02/2004-05/2015 was performed...
June 7, 2018: Annals of Thoracic Surgery
Ivan Adamec, Luka Crnošija, Anamari Junaković, Magdalena Krbot Skorić, Mario Habek
OBJECTIVE: To determine autonomic dysfunction (AD) differences in patients with relapsing remitting multiple sclerosis (pwRRMS) and progressive MS (pwPMS). METHODS: Composite autonomic scoring scale (CASS) and heart rate variability (HRV) were performed in 40 pwRRMS and 30 pwPMS. RESULTS: pwPMS had a significantly higher sudomotor index and total CASS score compared to pwRRMS (p < 0.001 and p < 0.001, respectively). Disease duration positively correlated with sudomotor index and total CASS (rs  = 0...
June 4, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Sophia Khattak, Iain Sim, Luke Dancy, Benjamin Whitelaw, Dan Sado
Myocarditis is inflammation of the cardiac muscle. The symptoms, signs and basic investigation findings can mimic that of myocardial infarction. The most common cause is infection (most commonly viral). Cardiovascular magnetic resonance (CMR) is the gold standard non-invasive diagnostic test for potential acute myocarditis as it allows assessment of myocardial oedema and scar. A man aged 25 years was admitted with chest pain, dizziness, headache, palpitations and sweating. His troponin was mildly positive. A CMR was performed which showed mild myocarditis and a right suprarenal mass which was confirmed to be a phaeochromocytoma based on biochemistry and a dedicated imaging workup...
June 8, 2018: BMJ Case Reports
Udit Chaddha, Pradnya D Patil, Ashraf Omar, Rajat Walia, Tanmay S Panchabhai
A 47-year-old man who was a redo double lung transplant recipient (cytomegalovirus [CMV] status: donor positive/recipient positive; Epstein-Barr virus status: donor positive/recipient positive) presented to the hospital with 1 week of generalized malaise, low-grade fevers, and dry cough. His redo lung transplantation was necessitated by bronchiolitis obliterans syndrome, and his previous lung transplantation 5 years earlier was for silicosis-related progressive massive fibrosis. He denied any difficulty breathing or chest pain...
June 2018: Chest
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