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https://www.readbyqxmd.com/read/29677207/sweat-glucose-and-glut2-expression-in-atopic-dermatitis-implication-for-clinical-manifestation-and-treatment
#1
Emi Ono, Hiroyuki Murota, Yuki Mori, Yoshichika Yoshioka, Yuko Nomura, Takichi Munetsugu, Hiroo Yokozeki, Ichiro Katayama
Sweat includes active components and metabolites, which are needed to maintain skin homeostasis. Component changes in sweat derived from atopic dermatitis (AD) have been reported. To investigate the influence of sweat components on the pathogenesis of AD, we performed a multifaceted assessment, including nuclear magnetic resonance spectroscopy-based metabolomic analysis, and linked these features to clinical features of AD. Distinctive properties of AD sweat are the quite-variation in protein, anti-microbial peptides and glucose concentrations...
2018: PloS One
https://www.readbyqxmd.com/read/29676381/ectopic-hidradenoma-papilliferum-of-eyelid-a-rare-entity-with-diagnostic-challenge
#2
Prakriti Shukla, Anil K Malaviya
Hidradenoma papilliferum is a rare cutaneous adnexal tumour of middle aged females arising mainly in the apocrine sweat glands of perianal and genital region. Ectopic forms of this entity have been described with majority of them occurring on the head and neck region. We report a case of 16 years young male who presented with two small, well circumscribed, greyish-brown, firm, nodules on his left upper and lower eyelid. A clinical impression of basal cell carcinoma was assumed but on histopathological examination it was diagnosed as hidradenoma papilliferum of eyelid...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29674725/droplet-bubbling-evaporatively-cools-a-blowfly
#3
Guilherme Gomes, Roland Köberle, Claudio J Von Zuben, Denis V Andrade
Terrestrial animals often use evaporative cooling to lower body temperature. Evaporation can occur from humid body surfaces or from fluids interfaced to the environment through a number of different mechanisms, such as sweating or panting. In Diptera, some flies move tidally a droplet of fluid out and then back in the buccopharyngeal cavity for a repeated number of cycles before eventually ingesting it. This is referred to as the bubbling behaviour. The droplet fluid consists of a mix of liquids from the ingested food, enzymes from the salivary glands, and antimicrobials, associated to the crop organ system, with evidence pointing to a role in liquid meal dehydration...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669433/investigation-on-aetiological-factors-in-patients-with-hyperhidrosis
#4
Ayşe Akbaş, Fadime Kilinç
BACKGROUND: Hyperhidrosis is a condition where the amount of sweat released to skin surface increases due to the over-active eccrine sweat glands. Hyperhidrosis causes considerable psychosocial distress in affected people. It affects the quality of life and leads to social anxiety disorders. AIMS: No study has been conducted in our country to investigate the epidemiological, clinical and laboratory data of patients with hyperhidrosis. In this study, we aimed to retrospectively investigate the clinical and demographic characteristics, causes of sweating and laboratory findings in patients treated for hyperhidrosis at our outpatient clinic and to compare these data with the literature data...
April 18, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29667149/three-dimensional-reconstructed-eccrine-sweat-glands-with-vascularization-and-cholinergic-and-adrenergic-innervation
#5
Mingjun Zhang, Haihong Li, Liyun Chen, Shuhua Fang, Sitian Xie, Changmin Lin
Functional integrity of the regenerated tissues requires not only structural integrity but also vascularization and innervation. We previously demonstrated that the three-dimensional (3D) reconstructed eccrine sweat glands had similar structures as those of the native ones did, but whether the 3D reconstructed glands possessing vascularization and innervation was still unknown. In the study, Matrigel-embedded eccrine sweat gland cells were implanted under the inguinal skin. Ten weeks post-implantation, the vascularization, and innervation in the 10-week reconstructed eccrine sweat glands and native human eccrine sweat glands were detected by immunofluorescence staining...
April 17, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29663538/methylxanthine-drug-monitoring-with-wearable-sweat-sensors
#6
Li-Chia Tai, Wei Gao, Minghan Chao, Mallika Bariya, Quynh P Ngo, Ziba Shahpar, Hnin Y Y Nyein, Hyejin Park, Junfeng Sun, Younsu Jung, Eric Wu, Hossain M Fahad, Der-Hsien Lien, Hiroki Ota, Gyoujin Cho, Ali Javey
Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to prescriptions, and understand the complex pharmacokinetics of drugs. Conventional drug tests rely on invasive blood draws. While urine and sweat are attractive alternative biofluids, the state-of-the-art methods require separate sample collection and processing steps and fail to provide real-time information. Here, a wearable platform equipped with an electrochemical differential pulse voltammetry sensing module for drug monitoring is presented...
April 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29662322/a-comparative-trial-of-ice-application-versus-emla-cream-in-alleviation-of-pain-during-botulinum-toxin-injections-for-palmar-hyperhidrosis
#7
Adel Alsantali
Background: Botulinum toxin is a safe and effective therapy for palmar hyperhidrosis, but the associated pain from injections limits the usefulness of this method of treatment. Purpose: To evaluate the efficacy of Eutectic Mixture of Local Anesthetics (EMLA) cream versus ice application in alleviation of pain during botulinum toxin injections for palmar hyperhidrosis. Methods: In this prospective study, 23 patients underwent palm Botox injections to treat their excessive sweating...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29660167/muse-microscopy-with-uv-surface-excitation-a-novel-approach-to-real-time-inexpensive-slide-free-dermatopathology
#8
Amir Qorbani, Farzad Fereidouni, Richard Levenson, Sana Yasmine Lahoubi, Zachary T Harmany, Austin Todd, Maxwell A Fung
Traditional histology relies on processing and physically sectioning either frozen or formalin-fixed, paraffin-embedded (FFPE) tissue into thin slices (typically 4-6 microns) prior to staining and viewing on a standard wide-field microscope. MUSE represents a novel alternative microscopy method that works with ultraviolet (UV) excitation using oblique cis-illumination which can generate high-quality images from the cut surface of fresh or fixed tissue after brief staining, with no requirement for fixation, embedding and histological sectioning of tissue specimens...
April 16, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29659406/topical-botulinum-toxin-type-a-liposomal-cream-for-primary-axillary-hyperhidrosis-a-double-blind-randomized-split-site-vehicle-controlled-study
#9
Suparuj Lueangarun, Chairat Sermsilp, Therdpong Tempark
BACKGROUND: Despite its effectiveness in treating primary axillary hyperhidrosis (PAH), topical botulinum toxin type A (BTX-A) is highly resistant to transdermal absorption. Topical BTX-A liposomal cream is recommended as a novel, noninvasive modality to enhance skin penetration. OBJECTIVE: To evaluate the efficacy and safety of topical BTX-A liposomal cream in comparison with liposomal vehicle cream alone in the treatment of PAH. MATERIALS AND METHODS: A prospective, randomized, double-blinded, split-site study was conducted in 20 subjects, aged 18 to 50 years, all of whom had symmetrical axillary sweating with Hyperhidrosis Disease Severity Scale scores between 2 to 4...
April 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29651916/assessment-of-exposure-risk-of-irinotecan-and-its-active-metabolite-sn-38-through-perspiration-during-chemotherapy
#10
Kei Irie, Akira Okada, Yoshio Masuda, Keizo Fukushima, Nobuyuki Sugioka, Chiyuki Okuda, Akito Hata, Reiko Kaji, Yutaka Okada, Nobuyuki Katakami, Shoji Fukushima
Background Irinotecan (CPT-11) is the key drug used in chemotherapy for many malignant tumors. CPT-11 has cholinergic activity and induces perspiration during intravenous administration. In this study, concentrations of CPT-11 and its active metabolite, SN-38, released during perspiration were measured and risk of exposure of these drugs was assessed. Method Beads of sweat were collected using a dropper from four patients undergoing a chemotherapy regimen involving intravenous administration of CPT-11. The concentrations of CPT-11 and SN-38 in sweat were measured using liquid chromatography tandem mass spectrometry...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29650525/flushing-disorders-associated-with-gastrointestinal-symptoms-part-1-neuroendocrine-tumors-mast-cell-disorders-and-hyperbasophila
#11
REVIEW
Vaibhav Rastogi, Devina Singh, Joseph J Mazza, Dennis Yang, Dipendra Parajuli, Steven H Yale
Flushing is the subjective sensation of warmth accompanied by visible cutaneous erythema occurring throughout the body with a predilection for the face, neck, pinnae, and upper trunk where the skin is thinnest and cutaneous vessels are superficially located and in greatest numbers. Flushing can be present in either a wet or dry form depending upon whether neural-mediated mechanisms are involved. Activation of the sympathetic nervous system results in wet flushing, accompanied by diaphoresis, due to concomitant stimulation of eccrine sweat glands...
April 12, 2018: Clinical Medicine & Research
https://www.readbyqxmd.com/read/29650028/a-rare-presentation-of-pulmonary-sarcoidosis-as-a-solitary-lung-mass-a-case-report
#12
Dylan W Kelleher, Madeleine Yaggi, Robert Homer, Erica L Herzog, Changwan Ryu
BACKGROUND: Sarcoidosis is a multisystem, chronic granulomatous disease of unknown etiology that predominantly affects the lungs. Pulmonary sarcoidosis classically presents with constitutional symptoms and computed tomographic scan findings of bilateral, symmetric micronodules in a peribronchovascular distribution with upper and middle lung zone predominance accompanied by bilateral, symmetric hilar lymphadenopathy. A solitary lung mass is a rare finding for pulmonary sarcoidosis, and with its associated constitutional symptoms, it strongly mimics a malignancy...
April 13, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29649196/diagnosis-of-abdominal-tuberculosis-in-christchurch-new-zealand-a-case-series
#13
James Bevin, Simon Dalton, Chris Wakeman, Will Perry
AIM: Abdominal tuberculosis presents with non-specific symptoms, including generalised abdominal pain. Prompt and accurate diagnosis is critical to improving outcomes and avoiding complications. We conducted a retrospective review of cases of abdominal tuberculosis presenting to Christchurch Hospital to explore the epidemiology, clinical features and diagnostic modalities used. METHOD: Cases were identified by searching for relevant ICD discharge codes from January 1996 to January 2016...
April 13, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29644077/unusual-presentation-of-pheochromocytoma-thirteen-years-of-anxiety-requiring-psychiatric-treatment
#14
Catherine Alguire, Jessica Chbat, Isabelle Forest, Ariane Godbout, Isabelle Bourdeau
Pheochromocytoma is a rare tumor of the adrenal gland. It often presents with the classic triad of headache, palpitations and generalized sweating. Although not described as a typical symptom of pheochromocytoma, anxiety is the fourth most common symptom reported by patients suffering of pheochromocytoma. We report the case of a 64 year old man who had severe anxiety and panic disorder as presenting symptoms of pheochromocytoma. After 13 years of psychiatric follow-up, the patient was diagnosed with malignant pheochromocytoma...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29643124/myocardial-ischemia-as-a-result-of-external-coronary-compression-from-infective-aortic-root-aneurysm-atypical-presentation-of-prosthetic-valve-endocarditis
#15
Baskar Sekar, Richard Wheeler, Navroz Masani, Sean Gallagher
This case describes an unusual presentation of prosthetic valve endocarditis: an acute coronary syndrome. A 67-year-old gentleman presented with cardiac sounding chest pain on a background of a short history of night sweats, weight loss and general malaise. Four months previously he had undergone bio-prosthetic aortic valve replacement for severe aortic stenosis and single vessel bypass grafting of the obtuse marginal. Whilst having chest pain his ECG showed infero-lateral ST depression. Early coronary angiography revealed a new right coronary artery lesion that was not present prior to his cardiac surgery...
April 11, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29627253/yeast-culture-increased-plasma-niacin-concentration-evaporative-heat-loss-and-feed-efficiency-of-dairy-cows-in-a-hot-environment
#16
Julia D L Dias, Rayana B Silva, Tatiane Fernandes, Eugenio F Barbosa, Larissa E C Graças, Rafael C Araujo, Renata A N Pereira, Marcos N Pereira
The supplementation of dairy cows with yeast culture may increase diet digestibility, plasma niacin concentration, heat dissipation, and lactation performance. Our objective was to evaluate the response of Holstein cows in late lactation (234 ± 131 d in milk) to dead yeast culture (YC, 15 g/d, Factor SC, GRASP, Saccharomyces cerevisiae) during Brazilian summer (temperature-humidity index >68 for 92.2% of the time). Thirty-two cows were individually fed a standard total mixed ration for 14 d and control (CTL) or YC treatments for 35 d, in a covariate adjusted complete randomized block design...
April 4, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29626974/a-young-man-with-hemoptysis-and-cavitary-lung-lesions
#17
Virginia A Brady, Andrey V Zinchuk, Mark D Siegel, Jennifer D Possick
A man in his 20s presented with 2 months of mild fatigue and intermittent hemoptysis of less than a tablespoon per episode. He was previously healthy and was on no medications. He denied fevers, night sweats, weight loss, wheezing, dyspnea, musculoskeletal symptoms, and rashes. He had emigrated from a South American country to the United States 3 years earlier. He worked as a groundskeeper but had no exposures to animals, mold, or dusts. He reported rare prior cigarette smoking with no history of alcohol or drug use...
April 2018: Chest
https://www.readbyqxmd.com/read/29626846/the-evolution-of-eccrine-sweat-gland-research-towards-developing-a-model-for-human-sweat-gland-function
#18
REVIEW
Douglas L Bovell
For several decades now, researchers, professional bodies, governments and journals such as the journal of Experimental Dermatology, have worked to reduce the number of animals used in experimentation. This review centers on investigations into how human sweat glands produce sweat and how that research has evolved over the years. It is hoped that this review will show, that as methodologies advanced, sweat gland research has come to rely less and less on a variety of animal models as investigative tools and information is being primarily obtained through human and mouse material, with a view to further reductions in using animal models...
April 7, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29624049/a-skin-attachable-stretchable-electrochemical-sweat-sensor-for-glucose-and-ph-detection
#19
Seung Yun Oh, Soo Yeong Hong, Yu Ra Jeong, Junyeong Yun, Heun Park, Sang Woo Jin, Geumbee Lee, Ju Hyun Oh, Hanchan Lee, Sang-Soo Lee, Jeong Sook Ha
As part of increased efforts to develop wearable healthcare devices for monitoring and managing physiological and metabolic information, stretchable electrochemical sweat sensors have been investigated. In this study, we report on the fabrication of a stretchable and skin-attachable electrochemical sensor for detecting glucose and pH in sweat. A patterned stretchable electrode was fabricated via layer-by-layer deposition of carbon nanotubes (CNT) on top of patterned Au nanosheets (AuNS) prepared by filtration onto stretchable substrate...
April 6, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29623230/hepatic-rupture-induced-by-spontaneous-intrahepatic-hematoma
#20
Jin-Bao Zhou, Wei-Bo Chen, Feng Zhu
The etiology of hepatic rupture is usually secondary to trauma, and hepatic rupture induced by spontaneous intrahepatic hematoma is clinically rare. We describe here a 61-year-old female patient who was transferred to our hospital with hepatic rupture induced by spontaneous intrahepatic hematoma. The patient had no history of trauma and had a history of systemic lupus erythematosus for five years, taking a daily dose of 5 mg prednisone for treatment. The patients experienced durative blunt acute right upper abdominal pain one day after satiation, which aggravated in two hours, accompanied by dizziness and sweating...
2018: Case Reports in Surgery
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