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angiotensinogen

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https://www.readbyqxmd.com/read/28416584/2-methoxyestradiol-reduces-angiotensin-ii-induced-hypertension-and-renal-dysfunction-in-ovariectomized-female-and-intact-male-mice
#1
Ajeeth K Pingili, Karen N Davidge, Shyamala Thirunavukkarasu, Nayaab S Khan, Akemi Katsurada, Dewan S A Majid, Frank J Gonzalez, L Gabriel Navar, Kafait U Malik
Cytochrome P450 1B1 protects against angiotensin II (Ang II)-induced hypertension and associated cardiovascular changes in female mice, most likely via production of 2-methoxyestradiol. This study was conducted to determine whether 2-methoxyestradiol ameliorates Ang II-induced hypertension, renal dysfunction, and end-organ damage in intact Cyp1b1(-/-), ovariectomized female, and Cyp1b1(+/+) male mice. Ang II or vehicle was infused for 2 weeks and administered concurrently with 2-methoxyestradiol. Mice were placed in metabolic cages on day 12 of Ang II infusion for urine collection for 24 hours...
April 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28396529/brain-renin-angiotensin-system-does-it-exist
#2
Bibi S van Thiel, Alexandre Góes Martini, Luuk Te Riet, David Severs, Estrellita Uijl, Ingrid M Garrelds, Frank P J Leijten, Ingrid van der Pluijm, Jeroen Essers, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Ludovit Paulis, Romana Rajkovicova, Oliver Domenig, Marko Poglitsch, A H Jan Danser
Because of the presence of the blood-brain barrier, brain renin-angiotensin system activity should depend on local (pro)renin synthesis. Indeed, an intracellular form of renin has been described in the brain, but whether it displays angiotensin (Ang) I-generating activity (AGA) is unknown. Here, we quantified brain (pro)renin, before and after buffer perfusion of the brain, in wild-type mice, renin knockout mice, deoxycorticosterone acetate salt-treated mice, and Ang II-infused mice. Brain regions were homogenized and incubated with excess angiotensinogen to detect AGA, before and after prorenin activation, using a renin inhibitor to correct for nonrenin-mediated AGA...
April 10, 2017: Hypertension
https://www.readbyqxmd.com/read/28395289/urinary-angiotensinogen-and-renin-excretion-are-associated-with-chronic-kidney-disease
#3
Annett Juretzko, Antje Steinbach, Anke Hannemann, Karlhans Endlich, Nicole Endlich, Nele Friedrich, Uwe Lendeckel, Sylvia Stracke, Rainer Rettig
BACKGROUND/AIMS: Several studies sought to identify new biomarkers for chronic kidney disease (CKD). As the renal renin-angiotensin system is activated in CKD, urinary angiotensinogen or renin excretion may be suitable candidates. We tested whether urinary angiotensinogen or renin excretion is elevated in CKD and whether these parameters are associated with estimated glomerular filtration rate (eGFR). We further tested whether urinary angiotensinogen or renin excretion may convey additional information beyond that provided by albuminuria...
April 11, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28379619/blood-pressure-lowering-efficacy-of-renin-inhibitors-for-primary-hypertension
#4
REVIEW
Vijaya M Musini, Kendra Ak Lawrence, Patricia M Fortin, Ken Bassett, James M Wright
BACKGROUND: Hypertension is a chronic condition associated with an increased risk of mortality and morbidity. Renin is the enzyme responsible for converting angiotensinogen to angiotensin I, which is then converted to angiotensin II. Renin inhibitors are a new class of drugs that decrease blood pressure (BP) by preventing the formation of both angiotensin I and angiotensin II. OBJECTIVES: To quantify the dose-related BP lowering efficacy of renin inhibitors compared to placebo in the treatment of primary hypertension...
April 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28378551/changes-in-urinary-angiotensinogen-associated-with-deterioration-of-kidney-function-in-patients-with-type-2-diabetes-mellitus
#5
Min Jin Lee, Sang Soo Kim, In Joo Kim, Sang Heon Song, Eun Heui Kim, Ji Yeong Seo, Jong Ho Kim, Sungsu Kim, Yun Kyung Jeon, Bo Hyun Kim, Yong Ki Kim
Urinary angiotensinogen (AGT) is potentially a specific biomarker for the status of the intrarenal renin-angiotensin system (RAS) in patients with diabetes mellitus. We explored whether changes in urinary AGT excretion levels were associated with the deterioration of kidney function in type 2 diabetes patients with preserved kidney function. Urinary baseline AGT levels were measured in 118 type 2 diabetic patients who were not taking RAS blockers and who had estimated glomerular filtration rates (eGFRs) ≥ 60 mL/min/1...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28376078/the-expression-of-renin-angiotensin-aldosterone-axis-components-in-infantile-hemangioma-tissue-and-the-impact-of-propranolol-treatment
#6
James R Dornhoffer, Ting Wei, Haihong Zhang, Emily Miller, Mario Cleves, Gresham T Richter
BACKGROUND: Propranolol's mechanism of action for controlling infantile hemangioma (IH) remains unclear. We hypothesize that this non-selective beta antagonist downregulates Renin-Angiotensin-Aldosterone (RAA) axis components, preventing angiogenic substrate induction of IH. METHODS: IH tissue and serum were collected from children with propranolol-treated or untreated IHs during surgery. Patients' normal skin and serum from demographically matched children were used as controls...
April 4, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28367083/proteomics-analysis-to-identify-and-characterize-the-biomarkers-and-physical-activities-of-non-frail-and-frail-older-adults
#7
Ching-Hung Lin, Chen-Chung Liao, Chi-Huang Huang, Yu-Tang Tung, Huan-Cheng Chang, Mei-Chich Hsu, Chi-Chang Huang
Globally, the proportion of older adults is increasing. Older people face chronic conditions such as sarcopenia and functional decline, which are often associated with disability and frailty. Proteomics assay of potential serum biomarkers of frailty in older adults. Older adults were divided into non-frail and frail groups (n = 6 each; 3 males in each group) in accordance with the Chinese-Canadian Study of Health and Aging Clinical Frailty Scale. Adults were measured for grip power and the 6-min walk test for physical activity, and venous blood was sampled after adults fasted for 8 h...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28362327/the-salutary-influence-of-forest-bathing-on-elderly-patients-with-chronic-heart-failure
#8
Genxiang Mao, Yongbao Cao, Bozhong Wang, Sanying Wang, Zhuomei Chen, Jirong Wang, Wenmin Xing, Xiaoxu Ren, Xiaoling Lv, Jianhua Dong, Shasha Chen, Xiuyuan Chen, Guofu Wang, Jing Yan
The aim of the current study was to test the hypothesis that forest bathing would be beneficial for elderly patients with chronic heart failure (CHF) as an adjunctive therapy. Two groups of participants with CHF were simultaneously sent to the forest or an urban control area for a four-day trip, respectively. Subjects exposed to the forest site showed a significant reduction of brain natriuretic peptide (BNP) in comparison to that of the city group and their own baseline levels. The values for the cardiovascular disease related pathological factors, including endothelin-1 (ET-1), and constituents of the renin-angiotensin system (RAS), including renin, angiotensinogen (AGT), angiotensin II (ANGII), and ANGII receptor type 1 or 2 (AT1 or AT2) in subjects exposed to the forest environment were lower than those in the urban control group...
March 31, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28361007/association-of-angiotensinogen-gene-snps-and-haplotypes-with-risk-of-hypertension-in-eastern-indian-population
#9
Pulakes Purkait, Kalpataru Halder, Sunil Thakur, Abhishikta Ghosh Roy, Pradip Raychaudhuri, Sandip Bhattacharya, B N Sarkar, J M Naidu
BACKGROUND: Angiotensinogen (AGT) enzyme comprises a vital module of RAAS system that effectively controls the blood pressure and related cardiovascular functions. Ample association studies have reported the importance of AGT variants in cardiovascular and non-cardiovascular adversities. But lately, owing to the complexity of the many anomalies, the haplotype based examination of genetic variation that facilitates the identification of polymorphic sites which are located in the vicinity of the causative polymorphic site, gets greater appreciation...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28356296/sex-dependent-effects-of-antenatal-glucocorticoids-on-insulin-sensitivity-in-adult-sheep-role-of-the-adipose-tissue-renin-angiotensin-system
#10
G Angela Massmann, Jie Zhang, Won Joon Seong, Minhyoung Kim, Jorge P Figueroa
Exposure to glucocorticoids in utero is associated with changes in organ function and structure in the adult. The aims of this study were to characterize the effects of antenatal exposure to glucocorticoids on glucose handling and the role of adipose tissue. Pregnant sheep received betamethasone (Beta, 0.17 mg/kg) or vehicle (V) 24-h apart at 80-days gestation and allowed to deliver at term. At 9 months, male and female offspring were fed at either 100% of nutritional allowance (lean) or ad libitum for 3 months (obese)...
March 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28344754/role-of-angiotensin-converting-enzyme-and-angiotensinogen-gene-polymorphisms-in-angiotensin-converting-enzyme-inhibitor-mediated-antiproteinuric-action-in-type-2-diabetic-nephropathy-patients
#11
Neerja Aggarwal, Pawan Kumar Kare, Parul Varshney, Om Prakash Kalra, Sri Venkata Madhu, Basu Dev Banerjee, Anil Yadav, Alpana Raizada, Ashok Kumar Tripathi
AIM: To investigate the role of genetic variants of angiotensin converting enzyme (ACE) and angiotensinogen (AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy (DN) patients. METHODS: In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor (ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio (ACR) in urine...
March 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28337615/longer-duration-of-obesity-is-associated-with-a-reduction-in-urinary-angiotensinogen-in-prepubertal-children
#12
Manuela Morato, Liane Correia-Costa, Teresa Sousa, Dina Cosme, Franz Schaefer, José Carlos Areias, António Guerra, Alberto Caldas Afonso, Henrique Barros, Ana Azevedo, António Albino-Teixeira
BACKGROUND: We aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender. Also, we aimed to evaluate whether plasma angiotensinogen (P-AGT) and hydrogen peroxide (H2O2) play a role in the putative association. METHODS: Cross-sectional evaluation of 305 children aged 8-9 years (160 normal weight, 86 overweight, and 59 obese). Anthropometric measurements and 24-h ambulatory blood pressure monitoring were performed...
March 23, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28337307/effects-of-microrna-29a-on-retinopathy-of-prematurity-by-targeting-agt-in-a-mouse-model
#13
Xin-Ke Chen, Li-Juan Ouyang, Zheng-Qin Yin, Yuan-You Xia, Xiu-Rong Chen, Hui Shi, Yan Xiong, Lian-Hong Pi
BACKGROUND: This study aimed to explore the effects of microRNA-29a (miR-29a) on retinopathy of prematurity (ROP) by targeting angiotensinogen (AGT) expression in a mouse model. METHODS: Ninety-six C57BL/6J mice were selected and divided into the normal control group (n = 12) and the oxygen-induced retinopathy (OIR) group (n = 84). All the mice in the OIR group were assigned to the following seven groups (12 mice in each group): the blank, miR-29a mimics, miR-29a inhibitors, empty plasmid, miR-29a mimics + si-AGT, miR-29a inhibitors + si-AGT and si-AGT groups...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28330766/water-metabolism-dysfunction-via-renin-angiotensin-system-activation-caused-by-liver-damage-in-mice-treated-with-microcystin-rr
#14
Qing Zhong, Feng Sun, Weiguang Wang, Wenqing Xiao, Xiaoni Zhao, Kangding Gu
Microcystins (MCs) are a group of monocyclic heptapeptide toxins that have been shown to act as potent hepatotoxins. However, the observed symptoms of water metabolism disruption induced by microcystin-RR (MC-RR) or MCs have rarely been reported, and a relatively clear mechanism has not been identified. In the present study, male mice were divided into 4 groups (A: 140μg/kg, B: 70μg/kg,C: 35μg/kg, and D: 0μg/kg) and administered MC-RR daily for a month. On day 8 of treatment, an increase in water intake and urine output was observed in the high-dose group compared with the control, and the symptoms worsened with the repeated administration of the toxin until day 30...
March 19, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28324005/insulin-inhibits-nrf2-gene-expression-via-heterogeneous-nuclear-ribonucleoprotein-f-k-in-diabetic-mice
#15
Anindya Ghosh, Shaaban Abdo, Shuiling Zhao, Chin-Han Wu, Yixuan Shi, Chao-Sheng Lo, Isabelle Chenier, Thierry Alquier, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Chan
Oxidative stress induces endogenous antioxidants via nuclear factor erythroid 2-related factor 2 (Nrf2), potentially preventing tissue injury. We investigated whether insulin affects renal Nrf2 expression in type 1 diabetes (T1D) and studied its underlying mechanism. Insulin normalized hyperglycemia, hypertension, oxidative stress, and renal injury; inhibited renal Nrf2 and angiotensinogen (Agt) gene expression; and upregulated heterogeneous nuclear ribonucleoprotein F and K (hnRNP F and hnRNP K) expression in Akita mice with T1D...
April 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28322753/myeloperoxidase-asymmetric-dimethyl-arginine-and-the-renin-angiotensin-aldosterone-system-in-cardiovascular-risk-patients-cross-sectional-findings-from-the-ludwigshafen-risk-and-cardiovascular-health-luric-study
#16
Sieglinde Zelzer, Dietmar Enko, Stefan Pilz, Andreas Tomaschitz, Winfried März, Andreas Meinitzer
OBJECTIVES: The leukocyte-derived myeloperoxidase (MPO), the nitric oxidase synthase (NOS) inhibitor asymmetrical dimethyl-arginine (ADMA) and the renin-angiotensin-aldosterone-system (RAAS) are associated with cardiovascular diseases (CVD). This study aimed to investigate potential interactions between the RAAS, ADMA and MPO in cardiovascular risk patients. DESIGN AND METHODS: All in all, 1446 patients, who were referred to coronary angiography, were included in this prospective study...
March 18, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28302554/structure-based-analysis-of-single-nucleotide-variants-in-the-renin-angiotensinogen-complex
#17
REVIEW
David K Brown, Olivier Sheik Amamuddy, Özlem Tastan Bishop
The renin-angiotensin system (RAS) plays an important role in regulating blood pressure and controlling sodium levels in the blood. Hyperactivity of this system has been linked to numerous conditions including hypertension, kidney disease, and congestive heart failure. As such, various classes of drugs have been developed to inhibit this system. These drugs are aimed at preventing angiotensin II from performing its function by inhibiting angiotensin II receptors or inhibiting angiotensin-converting enzyme from converting angiotensin I to angiotensin II...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28288872/local-renin-angiotensin-system-regulates-the-differentiation-of-mesenchymal-stem-cells-into-insulin-producing-cells-through-angiotensin-type-2-receptor
#18
Nermin Abdel-Hamid Sadik, Nadia Said Metwally, Olfat Gamil Shaker, Mahmoud Sanad Soliman, Ahmed Abdelaziz Mohamed, Mai Mohamed Abdelmoaty
Differentiation of stem cells into insulin-producing cells (IPCs) suitable for therapeutic transplantation offers a desperately needed approach for the diabetic patients. Elucidation of the molecular mechanisms during the differentiation of MSCs into IPCs assists the successful production of IPCs and provides an important insight into the improvement of the role of MSCs as a therapeutic tool for diabetes mellitus. The present study aimed to investigate the role of local renin-angiotensin system (RAS) on MSCs differentiation into IPCs by measuring the expression of local RAS in MSCs during the differentiation into IPCs and assessing the effect of angiotensin type 1 receptor (AT1R) blocker and angiotensin type 2 receptor (AT2R) blocker on the differentiation process...
March 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28283551/a-novel-role-for-mir-133a-in-centrally-mediated-activation-of-the-renin-angiotensin-system-in-congestive-heart-failure
#19
Neeru M Sharma, Shyam Sundar Nandi, Hong Zheng, Paras K Mishra, Kaushik P Patel
Activated renin-angiotensin system (RAS) within the central nervous system has been implicated in sympathoexcitation during various disease conditions including congestive heart failure (CHF). In particular, activation of RAS in the paraventricular nucleus (PVN) of the hypothalamus has been recognized to augment sympathoexcitation in CHF. We observed a 2.6-fold increase in angiotensinogen (AGT) in the PVN of CHF. To elucidate the molecular mechanism for increased expression of AGT, we performed in silico analysis of 3'-untranslated region (3'UTR) of AGT and found potential binding site for microRNA-133a(miR-133a)...
March 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28276504/pathologic-roles-of-receptor-associated-prorenin-system-in-idiopathic-epiretinal-membrane
#20
Yoko Dong, Atsuhiro Kanda, Kousuke Noda, Wataru Saito, Susumu Ishida
Receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates tissue renin-angiotensin system (RAS) and RAS-independent signaling via (P)RR. The aim of this study is to determine the association of RAPS with idiopathic epiretinal membrane (iERM). Reverse transcription-PCR indicated the expression of RAPS components, including (P)RR and Ang II type 1 receptor (AT1R), in iERM tissues and human Müller glial cell line. Double-labeling analyses demonstrated that (P)RR and AT1R were detected in cells positive for glial fibrillary acidic protein, a marker for glial cells, and co-localized with prorenin and angiotensinogen, respectively...
March 9, 2017: Scientific Reports
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