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Natalia Drabińska, Elżbieta Jarocka-Cyrta, Lidia Hanna Markiewicz, Urszula Krupa-Kozak
Celiac disease (CD) is associated with intestinal microbiota alterations. The administration of prebiotics could be a promising method of restoring gut homeostasis in CD. The aim of this study was to evaluate the effect of prolonged oligofructose-enriched inulin (Synergy 1) administration on the characteristics and metabolism of intestinal microbiota in CD children following a gluten-free diet (GFD). Thirty-four paediatric CD patients (mean age 10 years; 62% females) on a GFD were randomized into two experimental groups receiving Synergy 1 (10 g/day) or placebo (maltodextrin; 7 g/day) for 3 months...
February 12, 2018: Nutrients
Newsha Nourbehesht, Hajar Shekarchizadeh, Nafiseh Soltanizadeh
Inulin, rice bran oil and rosemary essential oil were used to produce high quality emulsion filled gel (EFG) using ultrasonic radiation. Response surface methodology was used to investigate the effects of oil content, inulin content and power of ultrasound on the stability and consistency of prepared EFG. The process conditions were optimized by conducting experiments at five different levels. Second order polynomial response surface equations were developed indicating the effect of variables on EFG stability and consistency...
April 2018: Ultrasonics Sonochemistry
Mircea Oroian, Sergiu Paduret, Sorina Ropciuc
BACKGROUND: The aim of this study is to evaluate the usefulness of a voltammetric e-tongue (three electrodes: reference electrode (Ag/AgCl), counter electrode (glassy carbon electrode rod) and working electrode (Au, Ag, Pt and glass electrode)) for honey adulteration detection. For this purpose a number of 55 samples of authentic honey (acacia, honeydew, sunflower, tilia and polyfloral) and 150 adulterated ones were analyzed. The adulteration was made using fructose, glucose, inverted sugar, hydrolyzed inulin syrup and malt wort in different percentages: with 5, 10, 20, 30, 40 and 50%, respectively...
February 10, 2018: Journal of the Science of Food and Agriculture
Kevin D'hoe, Lorenza Conterno, Francesca Fava, Gwen Falony, Sara Vieira-Silva, Joan Vermeiren, Kieran Tuohy, Jeroen Raes
Wheat bran fibers are considered beneficial to human health through their impact on gut microbiota composition and activity. Here, we assessed the prebiotic potential of selected bran fractions by performing a series of fecal slurry anaerobic fermentation experiments using aleurone as well as total, ultrafine, and soluble wheat bran (swb) as carbon sources. By combining amplicon-based community profiling with a fluorescent in situ hybridization (FISH) approach, we found that incubation conditions favor the growth of Proteobacteria such as Escherichia and Bilophila...
2018: Frontiers in Microbiology
Eloá Lourenço do Carmo, Rhana Amanda Ribeiro Teodoro, Pedro Henrique Campelo Félix, Regiane Victória de Barros Fernandes, Érica Resende de Oliveira, Taís Regina Lima Abreu Veiga, Soraia Vilela Borges, Diego Alvarenga Botrel
The properties and stability of spray-dried beetroot extract using maltodextrin (MD), inulin (IN), and whey protein isolate (WPI) as carrier agents were evaluated. The values of moisture, betalains content, and retention were 3.33-4.24%, 348.79-385.47 mg/100 g (dry-basis), and 88.45-95.69%, respectively. Higher values of antioxidant activity were observed for the treatments using WPI. The treatment with inulin alone presented higher hygroscopicity in the moisture adsorption isotherms at 25 °C and lower thermal stability when evaluating the thermogravimetric curves...
May 30, 2018: Food Chemistry
Barbara Speranza, Daniela Campaniello, Noemi Monacis, Antonio Bevilacqua, Milena Sinigaglia, Maria Rosaria Corbo
The aim of this study was to develop a functional fresh cream cheese with Bifidobacterium animalis subsp. lactis DSM 10140 or Lactobacillus reuteri DSM 20016 and prebiotics (inulin, FOS and lactulose). The research was divided into two steps: in vitro evaluation of the effects of prebiotic compounds; validation at laboratory level with production of functional cream mini-cheeses. Prebiotics showed a protective effect: B. animalis subsp. lactis DSM 10140 cultivability on Petri dishes was positively influenced by lactulose, whereas fructooligosaccharides (FOS) were the prebiotic compounds able to prolong Lb...
June 2018: Food Microbiology
Melanie P Chin, George L Bakris, Geoffrey A Block, Glenn M Chertow, Angie Goldsberry, Lesley A Inker, Hiddo J L Heerspink, Megan O'Grady, Pablo E Pergola, Christoph Wanner, David G Warnock, Colin J Meyer
BACKGROUND: Increases in measured inulin clearance, measured creatinine clearance, and estimated glomerular filtration rate (eGFR) have been observed with bardoxolone methyl in 7 studies enrolling approximately 2,600 patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The largest of these studies was Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes (BEACON), a multinational, randomized, double-blind, placebo-controlled phase 3 trial which enrolled patients with T2D and CKD stage 4...
January 18, 2018: American Journal of Nephrology
Lisa R Hoving, Margreet R de Vries, Rob C M de Jong, Saeed Katiraei, Amanda Pronk, Paul H A Quax, Vanessa van Harmelen, Ko Willems van Dijk
The prebiotic inulin has proven effective at lowering inflammation and plasma lipid levels. As atherosclerosis is provoked by both inflammation and hyperlipidemia, we aimed to determine the effect of inulin supplementation on atherosclerosis development in hypercholesterolemic APOE*3-Leiden (E3L) mice. Male E3L mice were fed a high-cholesterol (1%) diet, supplemented with or without 10% inulin for 5 weeks. At week 3, a non-constrictive cuff was placed around the right femoral artery to induce accelerated atherosclerosis...
February 3, 2018: Nutrients
Hong-Mei Shang, Hai-Zhu Zhou, Jun-Yan Yang, Ran Li, Hui Song, Hong-Xin Wu
This study was designed to investigate the in vitro and in vivo antioxidant activities of inulin. The in vitro assays demonstrated that the antioxidant activities of inulin, including the DPPH radical scavenging activity, ABTS scavenging activity and ferric reducing power, were weak and significantly lower than those of Vitamin C (P < 0.05). The influence of dietary supplementation with inulin on the antioxidant status of laying hens was evaluated with in vivo antioxidant assays. The results indicated that inulin supplementation quadratically improved the egg production rate of the laying hens (P < 0...
2018: PloS One
Vivek Kumar, Ashok Kumar Yadav, Yoshinari Yasuda, Masaru Horio, Vinod Kumar, Nancy Sahni, Krishan L Gupta, Seiichi Matsuo, Harbir Singh Kohli, Vivekanand Jha
BACKGROUND: Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correction factors in the originally developed creatinine-based GFR estimation equations for populations around the world. Existing equations have not been validated in the vegetarian Indian population. We examined the performance of creatinine and cystatin-based GFR estimating equations in Indians...
February 1, 2018: BMC Nephrology
Virginia Castel, Amelia C Rubiolo, Carlos R Carrara
No abstract text is available yet for this article.
January 2018: Food Research International
Irene A Rubel, Carolina Iraporda, Rocio Novosad, Fernanda A Cabrera, Diego B Genovese, Guillermo D Manrique
In this study the operational extraction variables to obtain higher yields of inulin from Jerusalem artichoke tubers (JAT), as well as the optimal conditions to obtain a stable and dispersible powdered product by either spray or freeze drying, were studied. With this purpose, the powder yield, moisture content, water activity and flowability or products obtained by different experimental conditions were analyzed. Inulin rich carbohydrates (IRC) extraction was performed from lyophilized and ground tubers employing distilled hot water as solvent...
January 2018: Food Research International
Livnat Afriat-Jurnou, Rami Cohen, Irina Paluy, Ran Ben-Adiva, Itamar Yadid
Inulinases are fructofuranosyl hydrolases that target the β-2,1 linkage of inulin and hydrolyze it into fructose, glucose and inulooligosaccharides (IOS), the latter are of growing interest as dietary fibers. Inulinases from various microorganisms have been purified, characterized and produced for industrial applications. However, there remains a need for inulinases with increased catalytic activity and better production yields to improve the hydrolysis process and fulfill the growing industrial demands for specific fibers...
February 1, 2018: Biotechnology Progress
Lian-Hua Cui, Chang-Guo Yan, Hui-Shan Li, Whee-Soo Kim, Liang Hong, Sang-Kee Kang, Yun-Jaie Choi, Chong-Su Cho
Synbiotics are a combination of probiotics and prebiotics, which lead to synergistic benefits in host welfare. Probiotics have been used as an alternative to antibiotics. Among the probiotics, Pediococcus acidilactici (PA) has shown excellent antimicrobial activity against Salmonella Gallinarum (SG) as a major poultry pathogen and has improved the production performances of animals. Inulin is widely used as a prebiotic for the improvement of animal health and growth. The main aim of this study is to investigate the effect of the antimicrobial activity of inulin nanoparticles (INs)-internalized PA encapsulated into alginate/chitosan/alginate (ACA) microcapsules (MCs) in future in vivo application...
February 1, 2018: Journal of Microbiology and Biotechnology
R A Pederzolli, A G Van Kessel, J Campbell, S Hendrick, K M Wood, G B Penner
The objective of this study was to determine effect of ruminal acidosis and low feed intake on the regional barrier function of the gastrointestinal tract. Twenty-one Holstein steers were fed for ad libitum intake for 5 d (CON), fed at 25% of ad libitum intake for 5 d (LFI), or provided 2 d of ad libitum intake follows by 1-d of feed restriction (25% of ad libitum intake), 1 day where 30% of ad libitum DMI was provided as pelleted barley followed by the full allocation (RA) and fed for ad libitum intake the following day...
January 29, 2018: Journal of Animal Science
Ryuji Nagata, Mao Echizen, Yukari Yamaguchi, Kyu-Ho Han, Kenichiro Shimada, Kiyoshi Ohba, Tomoko Kitano-Okada, Taizo Nagura, Hirokatsu Uchino, Michihiro Fukushima
The effect of a combination of inulin (INU) and polyphenol-containing adzuki bean extract (AE) on intestinal fermentation was examined in vitro using fermenters for 48 h and in vivo using rats for 28 d. The total short-chain fatty acid concentrations in the fermenters were decreased by a combination of INU and AE, but the concentration in the INU + AE group was higher than the cellulose (CEL) and CEL + AE groups. The cecal propionate concentration was increased by a combination of INU and AE compared with their single supplement...
January 31, 2018: Bioscience, Biotechnology, and Biochemistry
Yoshimitsu Gotoh, Osamu Uemura, Kenji Ishikura, Tomoyuki Sakai, Yuko Hamasaki, Yoshinori Araki, Riku Hamda, Masataka Honda
BACKGROUND: The gold standard for evaluation of kidney function is renal inulin clearance (Cin). However, the methodology for Cin is complicated and difficult, especially for younger children and/or patients with bladder dysfunction. Therefore, we developed a simple and easier method for obtaining the estimated glomerular filtration rate (eGFR) using equations and values for several biomarkers, i.e., serum creatinine (Cr), serum cystatin C (cystC), serum beta-2 microglobulin (β2MG), and creatinine clearance (Ccr)...
January 25, 2018: Clinical and Experimental Nephrology
Maria Wiese, Bekzod Khakimov, Sebastian Nielsen, Helena Sørensen, Frans van den Berg, Dennis Sandris Nielsen
Driven by the growing recognition of the influence of the gut microbiota (GM) on human health and disease, there is a rapidly increasing interest in understanding how dietary components, pharmaceuticals and pre- and probiotics influence GM. In vitro colon models represent an attractive tool for this purpose. With the dual objective of facilitating the investigation of rare and expensive compounds, as well as an increased throughput, we have developed a prototype in vitro parallel gut microbial fermentation screening tool with a working volume of only 5 ml consisting of five parallel reactor units that can be expanded with multiples of five to increase throughput...
2018: PeerJ
Hisashi Hoshida, Kenta Kidera, Ryuta Takishita, Nobuhisa Fujioka, Taiki Fukagawa, Rinji Akada
The production of extracellular proteins by the thermotolerant yeast Kluyveromyces marxianus, which utilizes various sugars, was investigated using media containing sugars such as glucose, galactose, and xylose. SDS-PAGE analysis of culture supernatants revealed abundant production of an extracellular protein when cells were grown in xylose medium. The N-terminal sequence of the extracellular protein was identical to a part of the inulinase encoded by INU1 in the genome. Inulinase is an enzyme hydrolyzing β-2,1-fructosyl bond in inulin and sucrose and is not required for xylose assimilation...
January 19, 2018: Journal of Bioscience and Bioengineering
Dongdong Wang, Feifei Sun, Chunbo Lu, Peng Chen, Zhaojie Wang, Yuanhao Qiu, Haibo Mu, Zehong Miao, Jinyou Duan
Colorectal cancer is one of the most common types of tumor in the world. Here we developed a lipoic acid esterified polysaccharide (inulin) delivery system for tanshinone IIA to treat colorectal cancer in vitro. The release of tanshinone IIA in the system was highly responsive to glutathione, which is commonly abundant in cancer cells. In addition, this drug delivery system was proliferative to Bifidobacterium longum, the common inhabitant of human intestine. Thus, this strategy might be useful to improve colon cancer therapy efficacy of anticancer drugs and meanwhile promote the growth of beneficial commensal flora in the gut...
January 20, 2018: International Journal of Biological Macromolecules
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