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https://www.readbyqxmd.com/read/28714842/molecular-and-biochemical-characteristics-of-the-inulosucrase-hugo-from-streptomyces-viridochromogenes-dsm40736-t%C3%A3-494
#1
Hans-Jörg Frasch, Sander S van Leeuwen, Lubbert Dijkhuizen
Polyfructans are synthesized from sucrose by plants (mostly inulin) and by both Gram-negative and Gram-positive bacteria (mostly levan). In the phylum Actinobacteria only levan synthesis by Actinomyces species has been reported. We have identified a putative fructansucrase gene (hugO) in Streptomyces viridochromogenes DSM40736 (Tü494). HugO was heterologously expressed and biochemically characterized. HPSEC-MALLS and 2D-1H-13C nuclear magnetic resonance (NMR) spectroscopy analysis showed that the fructan polymer produced in vitro has an Molecular Weight of 2...
July 17, 2017: Microbiology
https://www.readbyqxmd.com/read/28694176/anxiogenic-effects-of-a-lactobacillus-inulin-and-the-synbiotic-on-healthy-juvenile-rats
#2
Camila Barrera-Bugueño, Ornella Realini, Jorge Escobar-Luna, Ramón Sotomayor-Zárate, Martin Gotteland, Marcela Julio-Pieper, Javier A Bravo
Gut microbiota interventions, including probiotic and prebiotic use can alter behavior in adult animals and healthy volunteers. However, little is known about their effects in younger individuals. To investigate this, male Sprague-Dawley rats (post-natal day 21, PND21) received Lactobacillus casei 54-2-33 (10(4)cfu/ml), inulin as prebiotic (16mg/ml), or both together (synbiotic) via drinking water for 14days. Control rats received water alone. Open field (OF) and elevated plus maze (EPM) behaviors were evaluated at PND34 and 35, respectively...
July 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/28692849/designing-healthier-comminuted-meat-products-effect-of-dietary-fibers-on-water-distribution-and-texture-of-a-fat-reduced-meat-model-system
#3
Minyi Han, Hanne Christine Bertram
Development of healthier meat products is needed to meet consumers' request. The effects of dietary fiber addition on the water distribution, water binding capacity (WBC), and textural properties of a fat-reduced model meat system enriched with inulin, cellulose, carboxymethyl cellulose (CMC), chitosan, pectin, respectively, were investigated in this study. The fibers were incorporated in powder form to constitute 2% (w/w) of the meat batter. In general, fiber enrichment resulted in significant lower cooking loss and improved WBC, while the impact on texture was dependent on the specific dietary fiber...
July 3, 2017: Meat Science
https://www.readbyqxmd.com/read/28686947/chicory-fructans-in-pig-diet-reduce-skatole-in-back-fat-of-entire-male-pigs
#4
M Aluwé, E Heyrman, S Theis, C Sieland, K Thurman, S Millet
Androstenone, skatole and indole are main compounds responsible for boar taint, an off-odour in meat of some entire male pigs. Several feed ingredients derived from chicory have been reported to reduce fat skatole levels, while results for indole are more contradictory. The skatole-reducing effect is probably based on the prebiotic effects described for fructan compounds. Inulin and oligofructose have a high and low degree of polymerization, respectively. The fermentation rate decreases with an increasing degree of polymerization, which may result in differing effects of the compounds on skatole and/or indole levels...
June 26, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28684691/administration-of-inulin-supplemented-gluten-free-diet-modified-calcium-absorption-and-caecal-microbiota-in-rats-in-a-calcium-dependent-manner
#5
Urszula Krupa-Kozak, Lidia H Markiewicz, Grzegorz Lamparski, Jerzy Juśkiewicz
In coeliac disease (CD), the risk of adverse calcium balance and reduced bone density is induced mainly by the disease, but also by a gluten-free diet (GFD), the only accepted CD therapy. Prebiotics through the beneficial impact on intestinal microbiota may stimulate calcium (Ca) absorption. In the present study, we hypothesised that the dietary inulin in GFD would influence positively the intestinal microbiota, and by that will stimulate the absorption of calcium (Ca), especially in the conditions of Ca malnutrition...
July 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28682148/pharmacokinetics-of-an-intracerebroventricularly-administered-antibody-in-rats
#6
Yuki Noguchi, Motohiro Kato, Kazuhisa Ozeki, Masaki Ishigai
The pharmacokinetics (PK) of an antibody in the brain and the spinal cord is insufficiently understood, which is an obstacle to the discovery of antibody drugs that target diseases in the central nervous system. In this study, we focused on the elimination of IgG from cerebrospinal fluid (CSF) circulating in the brain and the spinal cord in rats, and, in order to evaluate the influence of CSF bulk flow on the clearance of IgG, also examined the PK of inulin in CSF. To monitor their concentrations in CSF, IgG and inulin were co-administered into the lateral ventricle via a catheter, and CSF was collected from the cisterna magna via another catheter time-sequentially...
July 6, 2017: MAbs
https://www.readbyqxmd.com/read/28676886/production-of-functional-inulin-type-fructooligosaccharides-by-an-enzyme-from-penicillium-citrinum
#7
Yoshiya Tashiro, Hideo Ueno, Masakazu Takaba, Sachio Hayashi
We report the production of functional inulin-type fructooligosaccharides such as trisaccharide 1-kestose, O-β-D-fructofuranosyl-(2→1)-β-D-fructofuranosyl α-D-glucopyranoside, and tetrasaccharide nystose, O-β-D-fructofuranosyl-(2→1)-β-D-fructofuranosyl-(2→1)-β-D-fructofuranosyl α-D-glucopyranoside, from sucrose by an enzyme from Penicillium citrinum. Sucrose acted as a fructosyl donor and acceptor for the enzyme. The optimum pH and temperature for the enzymatic reaction were 5 and 50 °C, respectively...
July 4, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28676380/investigation-of-the-biodistribution-breakdown-and-excretion-of-delta-inulin-adjuvant
#8
Lixin Wang, Thomas Barclay, Yunmei Song, Paul Joyce, Isaac G Sakala, Nikolai Petrovsky, Sanjay Garg
Insoluble, nanostructured delta inulin particles enhance the immunogenicity of co-administered protein antigens and consequently are used as a vaccine adjuvant (Advax™). To better understand their immunomodulatory properties, the in vitro hydrolysis and in vivo distribution of delta inulin particles were investigated. Delta inulin particle hydrolysis under bio-relevant acidic conditions resulted in no observable change to the bulk morphology using SEM, and HPLC results showed that only 6.1% of the inulin was hydrolysed over 21days...
July 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28669593/pathogen-mimicking-vaccine-delivery-system-designed-with-a-bioactive-polymer-inulin-acetate-for-robust-humoral-and-cellular-immune-responses
#9
Hemachand Tummala, Sunny Kumar, Siddharth S Kesharwani, Bhimanna Kuppast, Mohammed Ali Bakkari
New and improved vaccines are needed against challenging diseases such as malaria, tuberculosis, Ebola, influenza, AIDS, and cancer. The majority of existing vaccine adjuvants lack the ability to significantly stimulate the cellular immune response, which is required to prevent the aforementioned diseases. This study designed a novel particulate based pathogen-mimicking vaccine delivery system (PMVDS) to target antigen-presenting-cells (APCs) such as dendritic cells. The uniqueness of PMVDS is that the polymer used to prepare the delivery system, Inulin Acetate (InAc), activates the innate immune system...
June 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28659890/pre-cultivation-with-selected-prebiotics-enhances-the-survival-and-the-stress-response-of-lactobacillus-rhamnosus-strains-in-simulated-gastrointestinal-transit
#10
Mariantonietta Succi, Patrizio Tremonte, Gianfranco Pannella, Luca Tipaldi, Autilia Cozzolino, Rossana Romaniello, Elena Sorrentino, Raffaele Coppola
In our study, we dwelled upon combinations of lactobacilli/prebiotics, considering four different strains belonging to the Lactobacillus rhamnosus species, including Lactobacillus rhamnosus GG (LGG), and different prebiotics often found in commercial synbiotic products, such as inulin, lactulose and polyols mannitol and sorbitol. In the first step of the research, the survival, the growth kinetic parameters and the protein expression of Lb. rhamnosus strains cultivated in presence of the different prebiotics as a unique carbon source were evaluated...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28656552/single-cell-oil-production-from-hydrolysates-of-inulin-by-a-newly-isolated-yeast-papiliotrema-laurentii-am113-for-biodiesel-making
#11
Guangyuan Wang, Lin Liu, Wenxing Liang
Microbial oils are among the most attractive alternative feedstocks for biodiesel production. In this study, a newly isolated yeast strain, AM113 of Papiliotrema laurentii, was identified as a potential lipid producer, which could accumulate a large amount of intracellular lipids from hydrolysates of inulin. P. laurentii AM113 was able to produce 54.6% (w/w) of intracellular oil in its cells and 18.2 g/l of dry cell mass in a fed-batch fermentation. The yields of lipid and biomass were 0.14 and 0.25 g per gram of consumed sugar, respectively...
June 27, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28656129/the-effects-of-synbiotic-bifidobacterium-lactis-b94-plus-inulin-addition-on-standard-triple-therapy-of-helicobacter-pylori-eradication-in-children
#12
Gonca Handan Ustundag, Halime Altuntas, Yasemin Dilek Soysal, Furuzan Kokturk
AIM: The aim of this study is to evaluate the effects of the synbiotic Bifidobacterium lactis B94 plus inulin addition to the standard triple therapy on Helicobacter pylori (H. pylori) infection eradication rates. METHODS: Children aged 6-16 years who had biopsy proven H. pylori infection were randomly classified into two groups. The first group received the standard triple therapy consisting of amoxicillin + clarithromycin + omeprazole. The second group was treated with the standard triple therapy and Bifidobacterium lactis B94 (5 × 10(9) CFU/dose) plus inulin (900 mg) for 14 days, concurrently...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28656099/effects-of-synbiotic-food-consumption-on-serum-minerals-liver-enzymes-and-blood-pressure-in-patients-with-type-2-diabetes-a-double-blind-randomized-cross-over-controlled-clinical-trial
#13
Zatollah Asemi, Mohammad Hossein Aarabi, Mohammad Hajijafari, Sabihe-Alsadat Alizadeh, Reza Razzaghi, Majid Mazoochi, Ahmad Esmaillzadeh
BACKGROUND: This research was to examine the effects of synbiotic intake on minerals, liver enzymes, and blood pressure in patients with type 2 diabetes (T2D). METHODS: This randomized, cross-over clinical trial was performed among 62 diabetic patients. Persons were randomly assigned to intake either a synbiotic (n = 62) or a control food (n = 62) for 6 weeks. A 3-week washout period was applied following which persons were crossed over to the alternate intervention arm for an additional 6 weeks...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28634691/modulation-of-rotavirus-severe-gastroenteritis-by-the-combination-of-probiotics-and-prebiotics
#14
REVIEW
Guadalupe Gonzalez-Ochoa, Lilian K Flores-Mendoza, Ramona Icedo-Garcia, Ricardo Gomez-Flores, Patricia Tamez-Guerra
Annual mortality rates due to infectious diarrhea are about 2.2 million; children are the most vulnerable age group to severe gastroenteritis, representing group A rotaviruses as the main cause of disease. One of the main factors of rotavirus pathogenesis is the NSP4 protein, which has been characterized as a viral toxin involved in triggering several cellular responses leading to diarrhea. Furthermore, the rotavirus protein NSP1 has been associated with interferon production inhibition by inducing the degradation of interferon regulatory factors IRF3, IRF5, and IRF7...
June 20, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28627061/glycaemic-and-insulinaemic-responses-of-adult-healthy-warm-blooded-mares-following-feeding-with-jerusalem-artichoke-meal
#15
M Glatter, M Bochnia, F Goetz, J Gottschalk, G Koeller, N Mielenz, D Hillegeist, J M Greef, A Einspanier, A Zeyner
This study aimed to investigate the impact of the supplementation of a pre-biotic compound [Jerusalem artichoke meal (JAM)] on the glycaemic and insulinaemic response in healthy, non-obese warm-blooded horses. Six adult mares [mean body weight (bwt) 529 ± 38.7 kg; body condition score 5.1 ± 0.49/9] were used. In two equal meals per day, the horses received crushed oat grains (1 g starch/kg bwt per day) and meadow hay (2 kg/100 kg bwt per day) which together were likely to meet the energy recommendation for light work (GfE, )...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28618173/inter-individual-differences-determine-the-outcome-of-wheat-bran-colonization-by-the-human-gut-microbiome
#16
Kim De Paepe, Frederiek-Maarten Kerckhof, Joran Verspreet, Christophe M Courtin, Tom Van de Wiele
Gut microbiota research reveals a vital role for the luminal and mucosal gut microbiota in human health. Fewer studies, however, have characterized the microbiome associated with undigested, insoluble dietary particles in the gut. These particles can act as a food source for bacteria and offer a physical platform to which they can attach. In this study, the microbiome colonizing wheat bran particles was analyzed. In a batch experiment, wheat bran particles were separately incubated with the fecal microbiota derived from ten donors and washed after 48h to remove loosely attached bacteria...
June 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28616072/the-advanced-strategy-for-enhancing-biobutanol-production-and-high-efficient-product-recovery-with-reduced-wastewater-generation
#17
Chuang Xue, Xiaotong Zhang, Jufang Wang, Min Xiao, Lijie Chen, Fengwu Bai
BACKGROUND: Butanol as an important chemical and potential fuel could be produced via ABE fermentation from lignocellulosic biomass. The use of food-related feedstocks such as maize and sugar cane may not be a sustainable solution to world's energy needs. Recently, Jerusalem artichoke tubers containing inulin have been used as feedstock for butanol production, but this bioprocess is not commercially feasible due to the great value of inulin as functional food. Till now, there is a gap on the utilization of Jerusalem artichoke stalk (JAS) as feedstock for microbial butanol production...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28596023/prebiotic-reduces-body-fat-and-alters-intestinal-microbiota-in-children-with-overweight-or-obesity
#18
Alissa C Nicolucci, Megan P Hume, Inés Martínez, Shyamchand Mayengbam, Jens Walter, Raylene A Reimer
BACKGROUND & AIMS: It might be possible to manipulate the intestinal microbiota with prebiotics or other agents to prevent or treat obesity. However, little is known about the ability of prebiotics to specifically modify gut microbiota in children with overweight/obesity or reduce body weight. We performed a randomized controlled trial to study the effects of prebiotics on body composition, markers of inflammation, bile acids in fecal samples, and composition of the intestinal microbiota in children with overweight or obesity...
June 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28594860/effect-of-probiotic-lactobacillus-on-lipid-profile-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Yucheng Wu, Qingqing Zhang, Yin Ren, Zhongbao Ruan
OBJECTIVE: To assess the efficacy of probiotic Lactobacillus on serum lipids using a meta-analysis of randomized, controlled trials. METHODS: Fifteen studies containing 15 trials, with 976 subjects were included. The pooled WMD was calculated by random effects model. RESULTS: Probiotic Lactobacillus consumption significantly reduced TC by 0.26mmol/l (95% CI, -0.40 to -0.12) and LDL-C by 0.23mmol/l (95% CI, -0.36 to -0.10). Subgroup analysis of trials found significantly reduction of TC using L...
2017: PloS One
https://www.readbyqxmd.com/read/28590342/supplementation-of-low-and-high-fat-diets-with-fermentable-fiber-exacerbates-severity-of-dss-induced-acute-colitis
#20
Jennifer P Miles, Jun Zou, Matam-Vijay Kumar, Michael Pellizzon, Edward Ulman, Matthew Ricci, Andrew T Gewirtz, Benoit Chassaing
BACKGROUND: Lack of dietary fiber has been suggested to increase the risk of developing various chronic inflammatory diseases, whereas supplementation of diets with fiber might offer an array of health-promoting benefits. Consistent with this theme, we recently reported that in mice, compositionally defined diets that are made with purified ingredients and lack fermentable fiber promote low-grade inflammation and metabolic syndrome, both of which could be ameliorated by supplementation of such diets with the fermentable fiber inulin...
July 2017: Inflammatory Bowel Diseases
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