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https://www.readbyqxmd.com/read/28424190/odd-chain-fatty-acids-as-a-biomarker-for-dietary-fiber-intake-a-novel-pathway-for-endogenous-production-from-propionate
#1
Karolin Weitkunat, Sara Schumann, Daniela Nickel, Silke Hornemann, Klaus J Petzke, Matthias B Schulze, Andreas Fh Pfeiffer, Susanne Klaus
Background: The risk of type 2 diabetes is inversely correlated with plasma concentrations of odd-chain fatty acids [OCFAs; pentadecanoic acid (15:0) and heptadecanoic acid (17:0)], which are considered as biomarkers for dairy fat intake in humans. However, rodent studies suggest that OCFAs are synthesized endogenously from gut-derived propionate. Propionate increases with dietary fiber consumption and has been shown to improve insulin sensitivity.Objective: We hypothesized that OCFAs are produced in humans from dietary fibers by a novel endogenous pathway...
April 19, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28416401/polymeric-nanoparticles-for-sirna-delivery-production-and-applications
#2
Gennara Cavallaro, Carla Sardo, Emanuela Fabiola Craparo, Barbara Porsio E Gaetano Giammona
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for obtaining an ideal carrier for siRNA...
April 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28416145/the-ginkgo-biloba-extract-gbe-protects-the-kidney-from-damage-produced-by-a-single-and-low-dose-of-carbon-tetrachloride-in-adult-male-rats
#3
R M Chávez-Morales, F Jaramillo-Juárez, M L Rodríguez-Vázquez, M C Martínez-Saldaña, F A Posadas Del Río, J A Garfias-López
Gingko biloba leaves have been used as herbal medicine in China for 5000 years, and the standardized leaf extract (GB-STE) has some beneficial effects in the treatment of age-related, cardiovascular, and neurological diseases. The aim of this study was to investigate the renoprotective effects of the Gingko biloba extract (GbE) against the toxicity of a single and relatively low dose of carbon tetrachloride (CCl4). In male adult Wistar rats, we determined the urine flux, the concentration of total proteins in urine, the concentration of glucose in urine, and the concentration of malondialdehyde (MDA) in renal cortex as well as two markers of renal function (clearance of inulin and p-aminohippurate); we also compared the histological lesions caused by CCl4...
April 13, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28413905/pre-meal-inulin-consumption-does-not-affect-acute-energy-intake-in-overweight-and-obese-middle-aged-and-older-adults
#4
Katarina Smiljanec, Cassie M Mitchell, Olivia F Privitera, Andrew P Neilson, Kevin P Davy, Brenda M Davy
BACKGROUND: Three-fourths of adults older than 55 years in the United States are overweight or obese. Prebiotics including inulin-type fructans may benefit with weight management. AIM: We aimed to investigate the acute effects of pre-meal inulin consumption on energy intake (EI) and appetite in older adults. METHODS: Sedentary, overweight or obese middle-aged and older adults ( n = 7, 60.9 ± 4.4 years, BMI 32.9 ± 4.3 kg/m(2)) ingested inulin (10 g) or a water preload before each test period in a randomly assigned order...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28408434/renal-and-vascular-effects-of-uric-acid-lowering-in-normouricemic-patients-with-uncomplicated-type-1-diabetes
#5
Yuliya Lytvyn, Ronnie Har, Amy Locke, Vesta Lai, Derek Fong, Andrew Advani, Bruce A Perkins, David Z I Cherney
Higher plasma uric acid (PUA) levels are associated with lower GFR and higher blood pressure (BP) in patients with type 1 diabetes (T1D). Our aim was to determine the impact of PUA lowering on renal and vascular function in patients with uncomplicated T1D.T1D patients (n=49) were studied under eu- and hyperglycemic conditions at baseline and after PUA lowering with febuxostat (FBX) for 8 weeks. Healthy controls (HC) were studied under normoglycemic conditions (n=24). PUA, GFR (inulin), effective renal plasma flow (ERPF, paraaminohippurate), BP and hemodynamic responses to an infusion of angiotensin II (assessment of intrarenal RAAS) were measured pre- and post-FBX...
April 13, 2017: Diabetes
https://www.readbyqxmd.com/read/28407078/inulin-with-different-degrees-of-polymerization-modulates-composition-of-intestinal-microbiota-in-mice
#6
Limeng Zhu, Song Qin, Shixiang Zhai, Yonglin Gao, Lili Li
The study aimed to analyse the global influences of dietary inulin with different degrees of polymerization (DP) on intestinal microbial communities. 6-week-old male C57BL/6J mice were treated with fructo-oligosaccharides (FOS) and inulin for 6 weeks. Fecal samples were obtained at time point 0 and 6th week. 16S rRNA sequence analysis was used to measure intestinal microbiota performed on Illumina MiSeq platform. Influences of dietary inulin on intestinal microbiota were more complex effects than bifidogenic effects, relative abundance of butyrate-producing bacteria increased after interventions...
April 12, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28401294/drinking-and-water-permeability-in-the-pacific-hagfish-eptatretus-stoutii
#7
Chris N Glover, Chris M Wood, Greg G Goss
Hagfish are osmoconformers, maintaining an internal osmolality that matches their seawater habitats. Hagfish would, therefore, appear to have no physiological need to drink, but previous studies are equivocal regarding whether drinking in hagfish occurs. The current study addressed this knowledge gap, by examining drinking and water permeability in the Pacific hagfish, Eptatretus stoutii. One-third of analysed hagfish were shown to accumulate radiolabelled drinking rate markers (tritiated inulin and polyethylene glycol-4000) in their gut tissues; however, this was attributed to the presence of markers in the blood perfusing the digestive tract, following absorption through paracellular pathways at the gill...
April 11, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28393631/prebiotic-evaluation-of-red-seaweed-kappaphycus-alvarezii-using-in-vitro-colon-model
#8
Dayang Marshitah Bajury, Muhamad Hanif Rawi, Iqbal Hakim Sazali, Aminah Abdullah, Shahrul Razid Sarbini
Red seaweed (Kappaphycus alvarezii) cultivated from Sabah (RSS) and Langkawi (RSL) were digested using in vitro mouth, gastric and duodenal model. The digested seaweed then fermented in a pH-controlled batch culture system inoculated with human faeces to mimic the distal colon. Bacterial enumeration were monitored using fluorescent in situ hybridisation, and the fermentation end products, the short chain fatty acids (SCFA), were analysed using HPLC. Both RSS and RSL showed significant increase of Bifidobacterium sp...
April 10, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28392242/development-of-microdialysis-methodology-for-interstitial-insulin-measurement-in-rodents
#9
Ann E Griffin, Ruth Macdonald, Anton J M Wagenmakers, Janice M Marshall, Simon M Poucher
INTRODUCTION: Accurate assessment of muscle insulin sensitivity requires measurement of insulin concentration in interstitial fluid (ISF), but has proved difficult. We aimed to optimise measurement of ISF insulin concentrations in rat muscles in vivo using microdialysis. METHODS: Factorial experimental design experiments were performed in vitro to determine optimal conditions for insulin recovery with microdialysis probes. These conditions were tested in vivo, adjusted appropriately and used in lean and obese Zucker rats to compare ISF insulin concentrations basally and during hyperinsulinaemic-euglycaemic (HE) clamp...
April 6, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28381524/inulin-prebiotic-is-it-all-about-bifidobacteria
#10
Sandrine Paule Claus
No abstract text is available yet for this article.
April 5, 2017: Gut
https://www.readbyqxmd.com/read/28377388/targeting-the-gut-microbiota-with-inulin-type-fructans-preclinical-demonstration-of-a-novel-approach-in-the-management-of-endothelial-dysfunction
#11
Emilie Catry, Laure B Bindels, Anne Tailleux, Sophie Lestavel, Audrey M Neyrinck, Jean-François Goossens, Irina Lobysheva, Hubert Plovier, Ahmed Essaghir, Jean-Baptiste Demoulin, Caroline Bouzin, Barbara D Pachikian, Patrice D Cani, Bart Staels, Chantal Dessy, Nathalie M Delzenne
OBJECTIVE: To investigate the beneficial role of prebiotics on endothelial dysfunction, an early key marker of cardiovascular diseases, in an original mouse model linking steatosis and endothelial dysfunction. DESIGN: We examined the contribution of the gut microbiota to vascular dysfunction observed in apolipoprotein E knockout (Apoe(-/-)) mice fed an n-3 polyunsaturated fatty acid (PUFA)-depleted diet for 12 weeks with or without inulin-type fructans (ITFs) supplementation for the last 15 days...
April 4, 2017: Gut
https://www.readbyqxmd.com/read/28372184/effects-of-inulin-with-different-degree-of-polymerization-on-gelatinization-and-retrogradation-of-wheat-starch
#12
Denglin Luo, Yun Li, Baocheng Xu, Guangyue Ren, Peiyan Li, Xuan Li, Sihai Han, Jianxue Liu
The effects of three types of inulin, including FS (DP≤10), FI (DP of 2-60) and FXL (DP≥23), on the gelatinization and retrogradation characteristics of wheat starch were investigated. As the concentration of inulin added into starch increased, the gelatinization temperature increased whereas the breakdown value decreased, and the value of setback first decreased and then increased slightly. The three types of inulin with lower concentrations (<15%) all showed obvious suppression effects on the short-term retrogradation of wheat starch...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28371380/dietary-fat-content-modulates-the-hypolipidemic-effect-of-dietary-inulin-in-rats
#13
Kyu-Ho Han, Aiko Yamamoto, Ken-Ichiro Shimada, Hiroto Kikuchi, Michihiro Fukushima
SCOPE: Dietary fat content (low versus high fat) may modulate the serum lipid-lowering effect of high-performance (HP)-inulin. This study investigated the effect of dietary HP-inulin on metabolism in rats fed a low- or high-fat diet. METHODS AND RESULTS: Rats were fed a diet of 5% fat with 5% cellulose or 5% HP-inulin (average degree of polymerization = 24) (low-fat diet) or of 20% fat with 5% cellulose or 5% HP-inulin (high-fat diet) for 28 days. Total, HDL, and non-HDL cholesterols, and triglyceride concentrations in the serum were measured along with total lipid content of liver and feces...
March 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28368356/analysis-of-the-anti-cancer-effects-of-cincau-extract-premna-oblongifolia-merr-and-other-types-of-non-digestible-fibre-using-faecal-fermentation-supernatants-and-caco-2-cells-as-a-model-of-the-human-colon
#14
Samsu U Nurdin, Richard K Le Leu, Graeme P Young, James C R Stangoulis, Claus T Christophersen, Catherine A Abbott
Green cincau (Premna oblongifolia Merr) is an Indonesian food plant with a high dietary fibre content. Research has shown that dietary fibre mixtures may be more beneficial for colorectal cancer prevention than a single dietary fibre type. The aim of this study was to investigate the effects of green cincau extract on short chain fatty acid (SCFA) production in anaerobic batch cultures inoculated with human faecal slurries and to compare these to results obtained using different dietary fibre types (pectin, inulin, and cellulose), singly and in combination...
April 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28363806/novel-role-of-insulin-in-the-regulation-of-glucose-excretion-by-mourning-doves-zenaida-macroura
#15
Karen L Sweazea, Eldon J Braun, Richard Sparr
In mammals, insulin primarily lowers plasma glucose (PGlu) by increasing its uptake into tissues. Studies have also shown that insulin lowers PGlu in mammals by modulating glomerular filtration rate (GFR). Birds have naturally high PGlu and, although insulin administration significantly decreases glucose concentrations, birds are resistant to insulin-mediated glucose uptake into tissues. Since prior work has not examined the effects of insulin on GFR in birds, the purpose of the present study was to assess whether insulin can augment renal glucose excretion and thereby lower PGlu...
February 20, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28353071/the-preliminary-study-of-prebiotic-potential-of-polish-wild-mushroom-polysaccharides-the-stimulation-effect-on-lactobacillus-strains-growth
#16
Renata Nowak, Natalia Nowacka-Jechalke, Marek Juda, Anna Malm
PURPOSE: According to the vast body of evidence demonstrating that the intestinal microbiota is undoubtedly linked with overall health, including cancer risk, searching for functional foods and novel prebiotic influencing on beneficial bacteria is necessary. The present study aimed to investigate the potential of polysaccharides from 53 wild-growing mushrooms to stimulate the growth of Lactobacillus acidophilus and Lactobacillus rhamnosus and to determine the digestibility of polysaccharide fractions...
March 28, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28350268/molecular-and-biopharmaceutical-investigation-of-alginate-inulin-synbiotic-coencapsulation-of-probiotic-to-target-the-colon
#17
Abdelbasset Atia, Ahmed I Gomma, Ismail Fliss, Eric Beyssac, Ghislain Garrait, Muriel Subirade
Colon targeting, as a site-specific delivery for oral formulation, remains a major challenge, especially for sensitive bioactive components such as therapeutic forms of phages, live attenuated virus and prebiotics-probiotics association. Synbiotics could be used to protect encapsulated probiotics during the gastrointestinal tract and control their release in the colon. To achieve these goals, effective prebiotics, such as inulin, could be combined with alginate - the most exploited polymer used for probiotic encapsulation - in the form of beads...
April 19, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28343458/association-between-urinary-metabolic-profile-and-the-intestinal-effects-of-cocoa-in-rats
#18
Malen Massot-Cladera, Jordi Mayneris-Perxachs, Adele Costabile, Jonathan R Swann, Àngels Franch, Francisco J Pérez-Cano, Margarida Castell
The aim of this study was to elucidate the relationship between the urinary metabolic fingerprint and the effects of cocoa and cocoa fibre on body weight, hormone metabolism, intestinal immunity and microbiota composition. To this effect, Wistar rats were fed, for 3 weeks, a diet containing 10 % cocoa (C10) or two other diets with same the proportion of fibres: one based on cocoa fibre (CF) and another containing inulin as a reference (REF) diet. The rats' 24 h urine samples were analysed by an untargeted 1H NMR spectroscopy-based metabonomic approach...
March 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28341907/utilization-of-inulin-containing-waste-in-industrial-fermentations-to-produce-biofuels-and-bio-based-chemicals
#19
REVIEW
Stephen R Hughes, Nasib Qureshi, Juan Carlos López-Núñez, Marjorie A Jones, Joshua M Jarodsky, Luz Ángela Galindo-Leva, Mitchell R Lindquist
Inulins are polysaccharides that belong to an important class of carbohydrates known as fructans and are used by many plants as a means of storing energy. Inulins contain 20 to several thousand fructose units joined by β-2,1 glycosidic bonds, typically with a terminal glucose unit. Plants with high concentrations of inulin include: agave, asparagus, coffee, chicory, dahlia, dandelion, garlic, globe artichoke, Jerusalem artichoke, jicama, onion, wild yam, and yacón. To utilize inulin as its carbon and energy source directly, a microorganism requires an extracellular inulinase to hydrolyze the glycosidic bonds to release fermentable monosaccharides...
April 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28339522/influence-of-postbiotic-rg14-and-inulin-combination-on-cecal-microbiota-organic-acid-concentration-and-cytokine-expression-in-broiler-chickens
#20
K Y Kareem, T C Loh, H L Foo, S A Asmara, H Akit
This study examined the effects of different combinations of inulin and postbiotics RG14 on growth performance, cecal microbiota, volatile fatty acids (VFA), and ileal cytokine expression in broiler chickens. Two-hundred-and sixteen, one-day-old chicks were allocated into 6 treatment groups, namely, a basal diet (negative control, NC), basal diet + neomycin and oxytetracycline (positive control, PC), T1 = basal diet + 0.15% postbiotic RG14 + 1.0% inulin, T2 = basal diet + 0.3% postbiotic RG14 + 1.0% inulin, T3 = basal diet + 0...
October 6, 2016: Poultry Science
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