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Wei Qin, Adam Miranowicz, Peng-Bo Li, Xin-You Lü, J Q You, Franco Nori
We propose an experimentally feasible method for enhancing the atom-field coupling as well as the ratio between this coupling and dissipation (i.e., cooperativity) in an optical cavity. It exploits optical parametric amplification to exponentially enhance the atom-cavity interaction and, hence, the cooperativity of the system, with the squeezing-induced noise being completely eliminated. Consequently, the atom-cavity system can be driven from the weak-coupling regime to the strong-coupling regime for modest squeezing parameters, and even can achieve an effective cooperativity much larger than 100...
March 2, 2018: Physical Review Letters
Verena M Throm, David Männle, Thomas Giese, Andrea S Bauer, Matthias M Gaida, Juergen Kopitz, Thomas Bruckner, Konstanze Plaschke, Svetlana P Grekova, Klaus Felix, Thilo Hackert, Nathalia A Giese, Oliver Strobel
Smoking is associated with increased risk and poorer prognosis of pancreatic ductal adenocarcinoma (PDAC). Nicotine acts through cholinergic nicotinic receptors, preferentially α7 (CHRNA7) that also binds the endogenous ligand SLURP1 (Secreted Ly-6/uPAR-Related Protein 1). The clinical significance of SLURP1 and its interaction with nicotine in PDAC are unclear. We detected similar levels of SLURP1 in sera from healthy donors and patients with chronic pancreatitis or PDAC; higher preoperative values were associated with significantly better survival in patients with resected tumors...
February 20, 2018: Oncotarget
Vadim I Agol, Anatoly P Gmyl
Reproduction of RNA viruses is typically error-prone due to the infidelity of their replicative machinery and the usual lack of proofreading mechanisms. The error rates may be close to those that kill the virus. Consequently, populations of RNA viruses are represented by heterogeneous sets of genomes with various levels of fitness. This is especially consequential when viruses encounter various bottlenecks and new infections are initiated by a single or few deviating genomes. Nevertheless, RNA viruses are able to maintain their identity by conservation of major functional elements...
June 2018: Microbiology and Molecular Biology Reviews: MMBR
Keesha L Roach, Patricia E Hershberger, Julienne N Rutherford, Robert E Molokie, Zaijie Jim Wang, Diana J Wilkie
Pain is the quintessential symptom for individuals suffering from sickle cell disease (SCD). Although the degree of suffering and the cost of treatment are staggering, SCD continues to be grossly understudied, including a lack of data for pain-related genes and prevalence of polymorphisms in this population. This lack of data adds to the inadequacy of pain therapy in this population. Pain genetics investigators have recently examined allele frequencies of single-nucleotide polymorphisms from candidate genes in people who have SCD...
March 1, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
J Sumankuuro, J Crockett, S Wang
OBJECTIVES: Maternal and neonatal healthcare outcomes in Sub-Saharan Africa (SSA) remain poor despite decades of different health service delivery interventions and stakeholder investments. Qualitative studies have attributed these results, at least in part, to sociocultural beliefs and practices. Thus there is a need to understand, from an overarching perspective, how these sociocultural beliefs affect maternal and neonatal health (MNH) outcomes. STUDY DESIGN: A qualitative meta-synthesis of primary studies on cultural beliefs and practices associated with maternal and neonatal health care was carried out, incorporating research conducted in any country within SSA, using data from men, women and health professionals gathered through focus group discussions, structured and semistructured interviews...
March 1, 2018: Public Health
Michael N Pham, Nicole Barbaro, Andrew M Holub, Christopher J Holden, Justin K Mogilski, Guilherme S Lopes, Sylis C A Nicolas, Yael Sela, Todd K Shackelford, Virgil Zeigler-Hill, Lisa L M Welling
Sperm competition theory can be used to generate the hypothesis that men alter the quality of their ejaculates as a function of sperm competition risk. Using a repeated measures experimental design, we investigated whether men produce a higher quality ejaculate when primed with cues to sperm competition (i.e., imagined partner infidelity) relative to a control prime. Men ( n = 45) submitted two masturbatory ejaculates-one ejaculate sample for each condition (i.e., sperm competition and control conditions). Ejaculates were assessed on 17 clinical parameters...
January 2018: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
James K McNulty, Andrea L Meltzer, Anastasia Makhanova, Jon K Maner
Two longitudinal studies of 233 newlywed couples suggest that automatic attentional and evaluative biases regarding attractive relationship alternatives can help people maintain relationships by avoiding infidelity. Both studies assessed participants' tendency to automatically disengage attention from photos of attractive, opposite sex individuals; one study assessed participants' tendency to devalue those individuals by comparing their attractiveness evaluations to evaluations made by single people, and both studies assessed infidelity and relationship status multiple times for approximately three years...
February 12, 2018: Journal of Personality and Social Psychology
Moses Kelly Kumwenda, Elizabeth Lucy Corbett, Jeremiah Chikovore, Mackwellings Phiri, Daniel Mwale, Augustine Talumba Choko, Marriot Nliwasa, Rodrick Sambakunsi, Miriam Taegtmeyer, Tore Jarl Gutteberg, Alister Munthali, Nicola Desmond
A community-based HIV self-testing study in Blantyre, Malawi demonstrated that not all individuals living in couples tested with their partner. We describe factors dissuading individuals in couples from self-testing with their partner. Data were drawn from qualitative study exploring consequences of HIV self-testing within couples. In-depth interviews were conducted with 33 individuals living in couples who tested alone. Participants expressed fear of dealing with HIV-discordant relationships. Failure to self-test with a partner was correlated with gender, with more men than women overtly declining or unconsciously unable to have joint HIV self-test...
February 6, 2018: AIDS and Behavior
Charles Negy, Diego Plaza, Abilio Reig-Ferrer, Maria Dolores Fernandez-Pascual
This cross-sectional study examined whether university students from the U.S. (n = 392) and Spain (n = 200) considered the viewing of sexually explicit material (SEM) to be tantamount to committing infidelity. Participants' ages ranged from 18 to 36 (U.S. sample) and 18 to 35 (Spain sample), respectively. At both universities, the study was made available to students via a computer program that allows recruitment and completion of the questionnaires online. It was found that the majority of U.S. and Spanish participants (73 and 77%, respectively) indicated that they did not consider viewing SEM as an act of infidelity...
February 1, 2018: Archives of Sexual Behavior
Stephanie R Barbari, Daniel P Kane, Elizabeth A Moore, Polina V Shcherbakova
DNA replication fidelity relies on base selectivity of the replicative DNA polymerases, exonucleolytic proofreading, and post-replicative DNA mismatch repair (MMR). Ultramutated human cancers without MMR defects carry alterations in the exonuclease domain of DNA polymerase ε (Polε). They have been hypothesized to result from defective proofreading. However, modeling in yeast of the most common variant, Polε-P286R, produced an unexpectedly strong mutator effect that exceeded the effect of proofreading deficiency by two orders of magnitude and indicated the involvement of other infidelity factors...
January 19, 2018: G3: Genes—Genomes—Genetics
Timothy Proctor, Kenneth Rudinger, Kevin Young, Mohan Sarovar, Robin Blume-Kohout
Randomized benchmarking (RB) is widely used to measure an error rate of a set of quantum gates, by performing random circuits that would do nothing if the gates were perfect. In the limit of no finite-sampling error, the exponential decay rate of the observable survival probabilities, versus circuit length, yields a single error metric r. For Clifford gates with arbitrary small errors described by process matrices, r was believed to reliably correspond to the mean, over all Clifford gates, of the average gate infidelity between the imperfect gates and their ideal counterparts...
September 29, 2017: Physical Review Letters
David E Melnikoff, April H Bailey
The preference for morality in others is regarded as a dominant factor in person perception. Moral traits are thought to foster liking, and immoral traits are thought to foster disliking, irrespective of the context in which they are embedded. We report the results of four studies that oppose this view. Using both explicit and implicit measures, we found that the preference for morality vs. immorality in others is conditional on the evaluator's current goals. Specifically, when immorality was conducive to participants' current goals, the preference for moral vs...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
Matamela Makongoza, Mzikazi Nduna
Intimate partner violence (IPV) is the most prevalent form of interpersonal violence experienced by women in South Africa. A study conducted with young women from South Africa, aged 13 to 23 years, estimated that 42% experienced physical violence from their intimate partners. The subtle and nuanced social dynamics of IPV are less understood owing to little qualitative research on this subject. This study qualitatively explored how young women perceive and experience IPV. Participants were recruited through snowballing from townships in Soweto, outside Johannesburg...
August 1, 2017: Journal of Interpersonal Violence
Domenico Tosini
This article adds to the literature on familicide by providing specific insights from the Italian experience. It presents results of an exploratory investigation into male-perpetrated familicides in Italy between 1992 and 2015. Familicide is defined as the killing of the spouse or intimate partner, and at least one child, at the hand of the other spouse/partner. Incidents of familicide were collated from newspaper reports. We identified 90 cases, resulting in 207 deaths. On average, perpetrators were middle aged ( M = 46...
July 1, 2017: Journal of Interpersonal Violence
Dr Yaniv Efrati, Professor Mario Mikulincer
Compulsive sexual behavior comprises individual-based (e.g., sexual fantasies, compulsive sexual thoughts, masturbation) and partnered (e.g., interpersonal sexual conquests, repeated infidelity) facets. Most instruments for assessing compulsive sexual behavior, however, focus less on the individual-based facet and specifically on fantasies and compulsive thoughts. In the current research, we developed and validated an individual-based compulsive sexual behavior scale (I-CSB). In Study 1 (N = 492), the factorial structure of the I-CSB was examined...
December 27, 2017: Journal of Sex & Marital Therapy
Dylan Selterman, Justin R Garcia, Irene Tsapelas
Relationship infidelities are motivated by many distinct factors, with previous research indicating motivations of dissatisfaction, neglect, anger, and sexual desire (Barta & Kiene, 2005). We expand on this by demonstrating additional, empirically distinct motivations for infidelity. Using an Internet-based questionnaire, participants (N = 495), most of whom were young adults, self-reported their infidelities. In addition to evidence for previously studied motivations, our data demonstrate additional factors, including lack of love ("I had 'fallen out of love with' my primary partner"), low commitment ("I was not very committed to my primary partner"), esteem ("I wanted to enhance my popularity"), gaining sexual variety ("I wanted a greater variety of sexual partners"), and situational factors ("I was drunk and not thinking clearly")...
December 15, 2017: Journal of Sex Research
Benjamin Warach, Lawrence Josephs, Bernard S Gorman
This study employed a structural equation modeling (SEM) approach to examine the interrelationships between the self-serving bias and various known predictors of infidelity. Specifically, we sought to generate a path model depicting how the following variables jointly predict sexual infidelity perpetration: (1) insecure attachment, (2) pathological narcissism, (3) sexual narcissism, (4) primary psychopathy, (5) self-serving attributions for retaliatory infidelity, and (6) sexual betrayal victimization. We developed a structural model describing various pathways to sexual infidelity perpetration based on these six variables...
December 14, 2017: Journal of Sex & Marital Therapy
Lakshmi Goparaju, Nathan C Praschan, Lari Warren-Jeanpiere, Laure S Experton, Mary A Young, Seble Kassaye
Background: Pre-Exposure Prophylaxis (PrEP) use has remained low among US women while significantly increasing among men who have sex with men. Besides lack of awareness, women face several social and structural barriers in gaining access to and using PrEP. Methods: Four focus group discussions with 20 HIV-negative women who live in the Washington DC metropolitan area. Results: The women expressed concerns about social and structural barriers to PrEP use...
September 2017: Journal of AIDS & Clinical Research
Xihan Guo, Juan Ni, Yuqian Zhu, Tao Zhou, Xiaoling Ma, Jinglun Xue, Xu Wang
Folates comprise the essential B9 vitamin that act as cofactors and cosubstrates in one-carbon metabolism for both biosynthesis and methylation of DNA and RNA. Folate deficiency (FD) has been shown to induce chromosomal instability (CIN), yet the underlying mechanisms are poorly understood. Here, we used human NCM460 colon mucosal cells as a model to investigate the effect of FD on spindle assembly checkpoint (SAC), a cell-cycle regulatory pathway preventing CIN during mitosis. Cells were maintained in medium containing 1...
November 19, 2017: Mutagenesis
Vishakha Sharma, Hoi Yan Chow, Donald Siegel, Elisa Wurmbach
Massively parallel sequencing (MPS) is a powerful tool transforming DNA analysis in multiple fields ranging from medicine, to environmental science, to evolutionary biology. In forensic applications, MPS offers the ability to significantly increase the discriminatory power of human identification as well as aid in mixture deconvolution. However, before the benefits of any new technology can be employed, a thorough evaluation of its quality, consistency, sensitivity, and specificity must be rigorously evaluated in order to gain a detailed understanding of the technique including sources of error, error rates, and other restrictions/limitations...
2017: PloS One
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