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https://www.readbyqxmd.com/read/28454045/canadian-harm-reduction-policies-a-comparative-content-analysis-of-provincial-and-territorial-documents-2000-2015
#1
REVIEW
T Cameron Wild, Bernie Pauly, Lynne Belle-Isle, Walter Cavalieri, Richard Elliott, Carol Strike, Kenneth Tupper, Andrew Hathaway, Colleen Dell, Donald MacPherson, Caitlin Sinclair, Kamagaju Karekezi, Benjamin Tan, Elaine Hyshka
BACKGROUND: Access to harm reduction interventions among substance users across Canada is highly variable, and largely within the policy jurisdiction of the provinces and territories. This study systematically described variation in policy frameworks guiding harm reduction services among Canadian provinces and territories as part of the first national multimethod case study of harm reduction policy. METHODS: Systematic and purposive searches identified publicly-accessible policy texts guiding planning and organization of one or more of seven targeted harm reduction services: needle distribution, naloxone, supervised injection/consumption, low-threshold opioid substitution (or maintenance) treatment, buprenorphine/naloxone (suboxone), drug checking, and safer inhalation kits...
April 25, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28453674/ntcard-a-streaming-algorithm-for-cardinality-estimation-in-genomics-data
#2
Hamid Mohamadi, Hamza Khan, Inanc Birol
Motivation: Many bioinformatics algorithms are designed for the analysis of sequences of some uniform length, conventionally referred to as k -mers. These include de Bruijn graph assembly methods and sequence alignment tools. An efficient algorithm to enumerate the number of unique k -mers, or even better, to build a histogram of k -mer frequencies would be desirable for these tools and their downstream analysis pipelines. Among other applications, estimated frequencies can be used to predict genome sizes, measure sequencing error rates, and tune runtime parameters for analysis tools...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28453528/guidance-in-author-instructions-of-hematology-and-oncology-journals-a-cross-sectional-and-longitudinal-study
#3
Ingrid Toews, Nadine Binder, Robert F Wolff, Guenes Toprak, Erik von Elm, Joerg J Meerpohl
BACKGROUND: The debate about the value of biomedical publications led to recommendations for improving reporting quality. It is unclear to what extent these recommendations have been endorsed by journals. We analyzed whether specific recommendations were included in author instructions, which journal characteristics were associated with their endorsement, how endorsement of the domains changed and whether endorsement was associated with change of impact factor between 2010 and 2015. METHODS: We considered two study samples consisting of "Hematology" and "Oncology" journals of the Journal Citation Report 2008 and 2014, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28453306/the-association-of-lung-clearance-index-with-copd-and-fev-1-reduction-in-men-born-in-1914
#4
Suneela Zaigham, Per Wollmer, Gunnar Engström
Lung Clearance Index (LCI) provides an overall measurement of ventilation inhomogeneity. This population-based study examines whether LCI predicts pulmonary obstruction and incidence of chronic obstructive pulmonary disease (COPD) events over a long-term follow-up. Multiple breath nitrogen washout and spirometry were performed in 674 men from the cohort "Men born in 1914" at age 55 years. Subjects were classified into quartiles (Q) of LCI and according to LCI above and below upper limit of normal (ULN). Incidence of COPD events (COPD hospitalisations or COPD-related deaths) were monitored over the remaining life span of the men, by linkage with national hospital registers...
April 28, 2017: COPD
https://www.readbyqxmd.com/read/28449360/biologic-variability-of-cardiac-troponin-i-in-healthy-dogs-and-dogs-with-different-stages-of-myxomatous-mitral-valve-disease-using-standard-and-high-sensitivity-immunoassays
#5
Randolph L Winter, Ashley B Saunders, Sonya G Gordon, Matthew W Miller, Geoffrey T Fosgate, Jan S Suchodolski, Jörg M Steiner
BACKGROUND: Biologic variability (BV) is one aspect of interpreting changes in biomarker concentrations known to be clinically important in people with cardiac disease, but it has not been adequately addressed in dogs so far. OBJECTIVES: The purpose of the study was to determine BV of cardiac troponin I (cTnI) in healthy dogs and dogs with 3 stages of myxomatous mitral valve disease (MMVD). METHODS: Healthy dogs and dogs with 3 stages of MMVD were prospectively assigned to groups based on comprehensive clinical evaluation using current guidelines...
April 27, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28449091/gwab-a-web-server-for-the-network-based-boosting-of-human-genome-wide-association-data
#6
Jung Eun Shim, Changbae Bang, Sunmo Yang, Tak Lee, Sohyun Hwang, Chan Yeong Kim, U Martin Singh-Blom, Edward M Marcotte, Insuk Lee
During the last decade, genome-wide association studies (GWAS) have represented a major approach to dissect complex human genetic diseases. Due in part to limited statistical power, most studies identify only small numbers of candidate genes that pass the conventional significance thresholds (e.g. P ≤ 5 × 10-8). This limitation can be partly overcome by increasing the sample size, but this comes at a higher cost. Alternatively, weak association signals can be boosted by incorporating independent data. Previously, we demonstrated the feasibility of boosting GWAS disease associations using gene networks...
April 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28449017/a-multifaceted-intervention-to-improve-primary-care-radiology-referral-quality-and-value-in-canterbury
#7
Kieran Holland, Graham McGeoch, Carolyn Gullery
AIMS: This article describes a seven-year multifaceted intervention leading to sustained improvement in primary care radiology referral quality and value in Canterbury, New Zealand, and discusses the transferability to other health systems. METHODS: Access criteria were developed with input from general practitioners and hospital-based specialists, and embedded in locally developed clinical pathways. A referral management service was created to streamline referral processes...
April 28, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28448975/validation-of-a-case-finding-algorithm-for-hidradenitis-suppurativa-using-administrative-coding-from-a-clinical-database
#8
Andrew Strunk, Margaretta Midura, Vassiliki Papagermanos, Allireza Alloo, Amit Garg
BACKGROUND: Requisite to the application of clinical databases for observational research in hidradenitis suppurativa (HS) is the identification of an accurate case cohort. OBJECTIVE: To assess the validity of utilizing administrative codes to establish the HS cohort from a large clinical database. METHODS: In this retrospective study using chart review as the reference standard, we calculated several estimates of the diagnostic accuracy of at least 1 ICD-9 code for HS...
April 28, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28448877/synthesis-structure-and-cytotoxicity-of-a-series-of-dioxidomolybdenum-vi-complexes-featuring-salan-ligands
#9
Satabdi Roy, Monalisa Mohanty, Sagarika Pasayat, Sudarshana Majumder, Kulanthaivel Senthilguru, Indranil Banerjee, Martin Reichelt, Hans Reuter, Ekkehard Sinn, Rupam Dinda
Seven hexacoordinated cis-dioxidomolybdenum(VI) complexes [MoO2L(1-7)] (1-7) derived from various tetradentate diamino bis(phenolato) "salan" ligands, N,N'-dimethyl-N,N'-bis-(2-hydroxy-3-X-5-Y-6-Z-benzyl)-1,2-diaminoethane {(X=Br, Y=Me, Z=H (H2L(1)); X=Me, YCl, Z=H (H2L(2)); X=(i)Pr, Y=Cl, Z=Me (H2L(3))} and N,N'-bis-(2-hydroxy-3-X-5-Y-6-Z-benzyl)-1,2-diaminopropane {(X=Y=(t)Bu, Z=H (H2L(4)); X=Y=Me, Z=H (H2L(5)); X=(i)Pr, YCl, Z=Me (H2L(6)); X=Y=Br, Z=H (H2L(7))} containing O-N donor atoms, have been isolated and structurally characterized...
April 18, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28448682/validation-of-the-behavioural-observation-scale-3-for-the-evaluation-of-pain-in-adults
#10
M Frasca, B Burucoa, S Domecq, N Robinson, V Dousset, M Cadenne, F Sztark, M Floccia
BACKGROUND: Many behavioural scales are available to assess pain but none are suitable for a quick evaluation of non-sedated and non-geriatric adults. The Behavioural Observation Scale 3 (BOS-3) is short, composed of five items. This study examined its feasibility and diagnostic performances. METHODS: Adult patients were included from medical and surgical departments of the University Hospital of Bordeaux. In a cross-sectional study, BOS-3 was compared to Numerical Rate Scale (NRS) with communicating patients (CP) and Behavioural Scale for the Elderly Person (ECPA2) with non-communicating patients (NCP)...
April 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28448607/complementing-the-topsoil-information-of-the-land-use-land-cover-area-frame-survey-lucas-with-modelled-n2o-emissions
#11
Emanuele Lugato, Lily Paniagua, Arwyn Jones, Wim de Vries, Adrian Leip
Two objectives of the Common Agricultural Policy post-2013 (CAP, 2014-2020) in the European Union (EU) are the sustainable management of natural resources and climate smart agriculture. To understand the CAP impact on these priorities, the Land Use/Cover statistical Area frame Survey (LUCAS) employs direct field observations and soil sub-sampling across the EU. While a huge amount of information can be retrieved from LUCAS points for monitoring the environmental status of agroecosystems and assessing soil carbon sequestration, a fundamental aspect relating to climate change action is missing, namely nitrous oxide (N2O) soil emissions...
2017: PloS One
https://www.readbyqxmd.com/read/28448307/explaining-performance-in-health-care-how-and-when-top-management-competencies-make-the-difference
#12
Milena Vainieri, Francesca Ferrè, Giorgio Giacomelli, Sabina Nuti
BACKGROUND: One of the most distinctive management competencies is related to the ability to structure the strategic vision, develop long-term plans, and communicate them efficiently to the employees in order to empower them to enact. These managerial competencies in complex organizations are strongly related to the capacity to engage professionals as a predictor of high-performing organizations. PURPOSE: The aim of this study was to investigate the relationship between top management competencies, information sharing, and organizational performance in public health care system and to look at the management role in assuring information sharing on organizational strategies to achieve professionals' engagement...
April 26, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28448160/validation-of-anam-for-cognitive-screening-in-a-mixed-clinical-sample
#13
Andrea S Vincent, Tresa M Roebuck-Spencer, L Eugenia Cox-Fuenzalida, Cady Block, James G Scott, Robert Kane
The Automated Neuropsychological Assessment Metrics (ANAM) is a library of computer based tests designed to measure cognitive function at a single time-point or longitudinally for detection of cognitive change. This study sought to validate ANAM as a cognitive screening tool for presence of confirmed neuropsychological diagnosis in an outpatient setting. Retrospective data analysis was conducted for 139 patients referred for outpatient neuropsychological assessment. Clinical diagnosis was made independent of ANAM test results and resulted in a diagnostic mix of both neurologic and psychologic etiologies...
April 27, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28447817/a-unified-framework-for-bounded-and-unbounded-numerical-estimation
#14
Dan Kim, John E Opfer
Representations of numerical value have been assessed by using bounded (e.g., 0-1,000) and unbounded (e.g., 0-?) number-line tasks, with considerable debate regarding whether 1 or both tasks elicit unique cognitive strategies (e.g., addition or subtraction) and require unique cognitive models. To test this, we examined how well a mixed log-linear model accounted for 86 5- to 9-year-olds' estimates on bounded and unbounded number-line tasks and how well it predicted mathematical performance. Compared with mixtures of 4 alternative models, the mixed log-linear model better predicted 76% of individual children's estimates on bounded number lines and 100% of children's estimates on unbounded number lines...
April 27, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28447341/chemotherapy-alone-versus-chemotherapy-plus-radiotherapy-for-adults-with-early-stage-hodgkin-lymphoma
#15
REVIEW
Oliver Blank, Bastian von Tresckow, Ina Monsef, Lena Specht, Andreas Engert, Nicole Skoetz
BACKGROUND: Combined modality treatment consisting of chemotherapy followed by localised radiotherapy is the standard treatment for patients with early stage Hodgkin lymphoma (HL). However, due to long- term adverse effects such as secondary malignancies the role of radiotherapy has been questioned recently and some clinical study groups advocate chemotherapy only for this indication. OBJECTIVES: To assess the effects of chemotherapy alone compared to chemotherapy plus radiotherapy in adults with early stage HL ...
April 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28447077/evidence-europe-2017-london-uk-february-22-23-2017
#16
A Kibble
As the political backdrop changes in both the U.S. and Europe, volatility in the pharma industry is beginning to be felt as the sector becomes sensitive to the uncertainty. U.S. President Trump has stated he will pursue an agenda against high U.S. drug prices and is expected to seek to repeal the Affordable Care Act, while in Europe, Brexit casts further unknowns in regulatory authorization procedures, trade and external reference pricing. With these factors in mind, Terrapin's Evidence Europe meeting provided for a very topical discussion on the use of evidence to define and communicate value in healthcare...
March 2017: Drugs of Today
https://www.readbyqxmd.com/read/28446741/methodology-to-define-biological-reference-values-in-the-environmental-and-occupational-fields-the-contribution-of-the-italian-society-for-reference-values-sivr
#17
Maria Cristina Aprea, Maria Luisa Scapellato, Maria Carmen Valsania, Andrea Perico, Luigi Perbellini, Maria Cristina Ricossa, Marco Pradella, Sara Negri, Ivo Iavicoli, Piero Lovreglio, Fabiola Salamon, Maurizio Bettinelli, Pietro Apostoli
BACKGROUND: Biological reference values (RVs) explore the relationships between humans and their environment and habits. RVs are fundamental in the environmental field for assessing illnesses possibly associated with environmental pollution, and also in the occupational field, especially in the absence of established biological or environmental limits. OBJECTIVES: The Italian Society for Reference Values (SIVR) determined to test criteria and procedures for the definition of RVs to be used in the environmental and occupational fields...
April 21, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28446573/serologic-testing-for-zika-virus-comparison-of-three-zika-virus-igm-elisas-and-initial-laboratory-experiences
#18
Dane Granger, Heather Hilgart, Lori Misner, Jaime Christensen, Sarah Bistodeau, Jennifer Palm, Anna K Strain, Marja Konstantinovski, Dakai Liu, Anthony Tran, Elitza S Theel
Serologic evaluation for Zika virus (ZIKV) infection currently includes an initial screen using an anti-ZIKV IgM antibody capture enzyme linked immunosorbent assay (MAC-ELISA) followed by supplemental testing of specimens with non-negative results by a plaque reduction neutralization test (PRNT). We compared the performance characteristics of three ELISAs for the detection of IgM-class antibodies to ZIKV, including the Centers for Disease Control and Prevention (CDC) Zika MAC-ELISA, the InBios ZIKV Detect™ MAC-ELISA, and the Euroimmun anti-Zika Virus IgM ELISA...
April 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28446455/the-economic-burden-of-physical-inactivity-a-systematic-review-and-critical-appraisal
#19
REVIEW
Ding Ding, Tracy Kolbe-Alexander, Binh Nguyen, Peter T Katzmarzyk, Michael Pratt, Kenny D Lawson
OBJECTIVE: To summarise the literature on the economic burden of physical inactivity in populations, with emphases on appraising the methodologies and providing recommendations for future studies. DESIGN: Systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO registration number CRD42016047705). DATA SOURCES: Electronic databases for peer-reviewed and grey literature were systematically searched, followed by reference searching and consultation with experts...
April 26, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28446293/-clinical-significance-of-peripheral-blood-eb-virus-detection-in-nk-t-cell-lymphoma-patients
#20
Jing Zhang, Lei Yue, Ying-Lu Li
OBJECTIVE: To explore the clinical significance of peripheral blood EB virus detection in NK/T cell lymphoma patients. METHODS: The positive rate of EB virus and EBV-DNA in 85 cases of NK/T cell lymphoma was assayed; the correlation of positive rate of EB virus with clinical staging, short-term and long-term prognosis was analyzed. RESULTS: The positive rate of EB virus in NK/T cell lymphoma was high (80.00%). The EBV-DNA copy number in peripheral blood leukocytes was higher than that in peripheral plasma (P<0...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
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