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https://www.readbyqxmd.com/read/28743160/the-prognostic-utility-of-baseline-alpha-fetoprotein-for-hepatocellular-carcinoma-patients
#1
Jack P Silva, Richard A Gorman, Nicholas G Berger, Susan Tsai, Kathleen K Christians, Callisia N Clarke, Harveshp Mogal, T Clark Gamblin
INTRODUCTION: Alpha-fetoprotein (AFP) has a valuable role in postoperative surveillance for hepatocellular carcinoma (HCC) recurrence. The utility of pretreatment or baseline AFP remains controversial. The present study hypothesized that elevated baseline AFP levels are associated with worse overall survival in HCC patients. METHODS: Adult HCC patients were identified using the National Cancer Database (2004-2013). Patients were stratified according to baseline AFP measurements into the following groups: Negative (<20), Borderline (20-199), Elevated (200-1999), and Highly Elevated (>2000)...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28742842/new-hydrazonoindolin-2-ones-synthesis-exploration-of-the-possible-anti-proliferative-mechanism-of-action-and-encapsulation-into-plga-microspheres
#2
Mohamed I Attia, Wagdy M Eldehna, Samar A Afifi, Adam B Keeton, Gary A Piazza, Hatem A Abdel-Aziz
The synthesis and molecular characterization of new isatin-based hydrazonoindolin-2-ones 4a-o and 7a-e are reported. The in vitro anti-proliferative potential of the synthesized compounds 4a-o and 7a-e was examined against HT-29 (colon), ZR-75 (breast) and A549 (lung) human cancer cell lines. Compounds 7b, 7d and 7e were the most active congeners against the tested human cancer cell lines with average IC50 values of 4.77, 3.39 and 2.37 μM, respectively, as compared with the reference isatin-based drug, sunitinib, which exhibited an average IC50 value of 8...
2017: PloS One
https://www.readbyqxmd.com/read/28742635/long-exercise-test-in-the-interattack-period-of-periodic-paralysis-a-useful-and-sensitive-diagnostic-tool
#3
Jiaoting Jin, Fangfang Hu, Min Li, Suhang Shang, Xing Qin, Hongmei Cao, Jingxia Dang
PURPOSE: The reference values of long exercise test are inconsistent in previous studies. Our research aims to determine the reference values and improve diagnostic efficiency of long exercise test in periodic paralysis. METHODS: In this study, 100 healthy controls, 35 non-periodic paralysis patients, and 47 patients with periodic paralysis were recruited. The procedures of long exercise test were conducted following McMannis(1986) method. RESULTS: The decrease rate in compound muscle action potential amplitudes was correlated with gender, and it was not influenced by age, height, weight, and exercise...
July 24, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28742257/dynamic-carboniferous-tropical-forests-new-views-of-plant-function-and-potential-for-physiological-forcing-of-climate
#4
REVIEW
Jonathan P Wilson, Isabel P Montañez, Joseph D White, William A DiMichele, Jennifer C McElwain, Christopher J Poulsen, Michael T Hren
Contents I. II. III. IV. V. VI. References SUMMARY: The Carboniferous, the time of Earth's penultimate icehouse and widespread coal formation, was dominated by extinct lineages of early-diverging vascular plants. Studies of nearest living relatives of key Carboniferous plants suggest that their physiologies and growth forms differed substantially from most types of modern vegetation, particularly forests. It remains a matter of debate precisely how differently and to what degree these long-extinct plants influenced the environment...
July 25, 2017: New Phytologist
https://www.readbyqxmd.com/read/28742128/construction-and-characterization-of-the-korean-whole-saliva-proteome-to-determine-ethnic-differences-in-human-saliva-proteome
#5
Ha Ra Cho, Han Sol Kim, Jun Seo Park, Seung Cheol Park, Kwang Pyo Kim, Troy D Wood, Yong Seok Choi
As the first step to discover protein disease biomarkers from saliva, global analyses of the saliva proteome have been carried out since the early 2000s, and more than 3,000 proteins have been identified in human saliva. Recently, ethnic differences in the human plasma proteome have been reported, but such corresponding studies on human saliva in this aspect have not been previously reported. Thus, here, in order to determine ethnic differences in the human saliva proteome, a Korean whole saliva (WS) proteome catalogue indexing 480 proteins was built and characterized through nLC-Q-IMS-TOF analyses of WS samples collected from eleven healthy South Korean male adult volunteers for the first time...
2017: PloS One
https://www.readbyqxmd.com/read/28742033/the-impact-of-model-based-clutter-suppression-on-cluttered-aberrated-wavefronts
#6
Kazuyuki Dei, Brett Byram
Recent studies reveal that both phase aberration and reverberation play a major role in degrading ultrasound image quality. We previously developed an algorithm for suppressing clutter, but we have not yet tested it in the context of aberrated wavefronts. In this study, we evaluate our previously reported algorithm, called aperture domain model image reconstruction (ADMIRE), in the presence of phase aberration and in the presence of multipath scattering and phase aberration. We use simulations to investigate phase aberration corruption and correction in the presence of reverberation...
July 20, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28741711/diffusion-tensor-imaging-in-multiple-sclerosis-at-different-final-outcomes
#7
O Andersen, A Hildeman, M Longfils, H Tedeholm, B Skoog, W Tian, J Zhong, S Ekholm, L Novakova, B Runmarker, O Nerman, S E Maier
OBJECTIVES: Methods to evaluate the relative contributions of demyelination vs axonal degeneration over the long-term course of MS are urgently needed. We used magnetic resonance diffusion tensor imaging (DTI) to estimate degrees of demyelination and axonal degeneration in the corpus callosum (CC) in cases of MS with different final outcomes. MATERIALS AND METHODS: We determined DTI measures mean diffusivity (MD), fractional anisotropy (FA), and axial (AD) and radial (RD) diffusivities in the CC of 31 MS patients, of whom 13 presented a secondary progressive course, 11 a non-progressive course, and seven a monophasic course...
July 25, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28741468/development-of-standard-reference-material-srm-2973-vitamin-d-metabolites-in-frozen-human-serum-high-level
#8
Susan Tai, Michael Nelson, Mary Bedner, Brian Lang, Karen Phinney, Lane Sander, James Yen, Joseph Betz, Christopher Sempos, Stephen Wise
The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health Office of Dietary Supplements and the Vitamin D Standardization Program, has recently issued a new serum-matrix Standard Reference Material (SRM): 2973 Vitamin D Metabolites in Frozen Human Serum (High Level). SRM 2973 was designed to provide a serum material with a total 25-hydroxyvitamin D [25(OH)D] concentration near 100 nmol/L to complement the existing serum-based SRMs with values assigned for total 25(OH)D between 20 and 80 nmol/L...
July 24, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28741442/a-systematic-review-of-the-methods-of-diagnostic-accuracy-studies-of-the-afirma%C3%A2-gene-expression-classifier
#9
Quan-Yang Duh, Naifa Busaidy, Catherine Rahilly-Tierney, Hossein Gharib, Gregory W Randolph
BACKGROUND: The Afirma® Gene Expression Classifier (GEC) risk-stratifies Bethesda System for the Reporting of Thyroid Cytopathology class III/IV (indeterminate) thyroid nodules (ITNs) as Suspicious for malignancy or Benign. Several authors have published studies describing the diagnostic accuracy of the GEC. However, the quality of these methods has not been rigorously examined. SUMMARY: We searched Medline and EMBASE for studies published between January 1, 2010 and June 30, 2016 examining the sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of the GEC...
July 25, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28741302/estimates-of-biologic-variation-in-specific-feline-pancreatic-lipase-concentrations-in-cats-without-clinical-or-ultrasonographic-evidence-of-pancreatitis
#10
Margaret Cohn-Urbach, Craig G Ruaux, Sarah Nemanic
BACKGROUND: Serum concentrations of feline-specific pancreatic lipase are commonly used for diagnosis and monitoring of pancreatitis in cats, but little is known regarding biologic variation of this analyte. OBJECTIVES: The purpose of the study was to determine biologic variation, index of individuality, and reference change values (RCV) for specific feline pancreatic lipase concentrations (Spec fPL) in apparently healthy cats. METHODS: Four blood samples were collected prospectively from 12 apparently healthy cats at 2-week intervals...
July 24, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28741108/automated-clean-up-separation-and-detection-of-polycyclic-aromatic-hydrocarbons-in-particulate-matter-extracts-using-a-2d-lc-2d-gc-system-a-method-translation-from-two-fids-to-two-ms-detectors
#11
Hwanmi Lim, Trifa M Ahmed, Christoffer Bergvall, Roger Westerholm
An online two-dimensional (2D) liquid chromatography/2D gas chromatography system with two mass-selective detectors has been developed on the basis of a previous system with two flame ionization detectors. The method translation involved the change of carrier gas from hydrogen to helium, column dimension and detectors. The 2D system with two mass-selective detectors was validated with use of polycyclic aromatic hydrocarbon (PAH) standards and two standard reference materials from air and diesel exhaust. Furthermore, the system was applied to a real sample, wood smoke particulates...
July 24, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28741093/fetal-right-ventricular-prominence-associated-postnatal-abnormalities-and-coarctation-clinical-prediction-tool
#12
Alyssa Power, Alberto Nettel-Aguirre, Deborah Fruitman
Fetal right ventricular (RV) prominence is a known indicator of possible left-sided structural heart disease with a low positive predictive value for aortic coarctation. There is a paucity of data on identifying which fetuses with RV prominence will have postnatal arch obstruction. Our study objectives were to create a clinical prediction tool for coarctation and to describe the diagnostic outcomes of our cohort with fetal RV prominence. We performed a retrospective review of patients referred with fetal RV prominence from January 2009 to October 2015...
July 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28741057/the-role-of-angiography-in-the-congruence-of-cardiovascular-measurements-between-autopsy-and-postmortem-imaging
#13
Renaud Troxler, Costin Minoiu, Paul Vaucher, Katarzyna Michaud, Francesco Doenz, Kewin Ducrot, Silke Grabherr
INTRODUCTION: Postmortem CT angiography is the method of choice for the postmortem imaging investigations of the cardiovascular (CV) system. However, autopsy still remains the gold standard for CV measurement. Nevertheless, there are not any studies on CV measurements on the multi-phase postmortem angiography (MPMCTA) which includes comparisons with autopsy. Therefore, the aim of this study is to compare CV measurements between the native CT scan and the three phases of the MPMCTA to find out which of these modalities correlate the best with autopsy measurements...
July 24, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28740918/impact-of-moving-target-on-measurement-accuracy-in-3d-and-4d-pet-imaging-a-phantom-study
#14
Yunfeng Cui, James Bowsher, Jing Cai, Fang-Fang Yin
PURPOSE: The purpose of this study was to evaluate the impact of tumor motion on maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) measurements in both 3-dimensional and respiratory-correlated, 4-dimensional positron emission tomography (PET) imaging. We also evaluated the effect of implementing different attenuation correction methods in 4-dimensional PET image reconstruction on SUVmax and MTV. METHODS AND MATERIALS: An anthropomorphic thorax phantom with a spherical ball as a surrogate for a tumor was used...
January 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740616/unlocking-the-potential-of-established-products-toward-new-incentives-rewarding-innovation-in-europe
#15
Gabrielle Nayroles, Sandrine Frybourg, Sylvie Gabriel, Åsa Kornfeld, Fernando Antoñanzas-Villar, Jaime Espín, Claudio Jommi, Nello Martini, Gérard de Pouvourville, Keith Tolley, Jürgen Wasem, Mondher Toumi
Background: Many established products (EPs - marketed for eight years or more) are widely used off-label despite little evidence on benefit-risk ratio. This exposes patients to risks related to safety and lack of efficacy, and healthcare providers to liability. Introducing new indications for EPs may represent a high societal value; however, manufacturers rarely invest in R&D for EPs. The objective of this research was to describe incentives and disincentives for developing new indications for EPs in Europe and to investigate consequences of current policies...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/28740596/improved-hepascore-in-hepatitis-c-predicts-reversal-in-risk-of-adverse-outcome
#16
Angus W Jeffrey, Yi Huang, W Bastiaan de Boer, Leon A Adams, Gerry MacQuillan, David Speers, John Joseph, Gary P Jeffrey
AIM: To establish if serial Hepascore tests (referred to as delta Hepascore) in those with chronic hepatitis C (CHC) correlate with the increase and/or decrease in risk of liver related complications. METHODS: Three hundred and forty-six CHC patients who had two Hepascore tests performed were studied. During 1944 patient years follow-up 28 (8.1%) reached an endpoint. The Hepascore is a serum test that provides clinically useful data regarding the stage of liver fibrosis and subsequent clinical outcomes in chronic liver disease...
July 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28740443/approaches-to-teach-evidence-based-practice-among-health-professionals-an-overview-of-the-existing-evidence
#17
REVIEW
Athina E Patelarou, Konstantinos G Kyriakoulis, Aliki A Stamou, Aggelos Laliotis, Dimitra Sifaki-Pistolla, Michail Matalliotakis, Emmanuel Prokopakis, Evridiki Patelarou
Health care professionals' adoption of evidence-based practice (EBP) remains limited, although most health care professionals are familiar with EBP and believe in its value. This systematic review aimed to bring together the best methods used to teach EBP to health professionals. The authors conducted a systematic search for the period 2005-2015 (an update of the search took place in October 2016) using PubMed interface (Medline). MeSH terms as well as free-text keywords were used. Studies were analyzed and evaluated by title and abstract...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28739581/a-novel-prognostic-model-for-transplant-free-survival-in-primary-sclerosing-cholangitis
#18
Elisabeth M de Vries, Junfeng Wang, Kate D Williamson, Mariska M Leeflang, Kirsten Boonstra, Rinse K Weersma, Ulrich Beuers, Roger W Chapman, Ronald B Geskus, Cyriel Y Ponsioen
OBJECTIVE: Most prognostic models for primary sclerosing cholangitis (PSC) are based on patients referred to tertiary care and may not be applicable for the majority of patients with PSC. The aim of this study was to construct and externally validate a novel, broadly applicable prognostic model for transplant-free survival in PSC, based on a large, predominantly population-based cohort using readily available variables. DESIGN: The derivation cohort consisted of 692 patients with PSC from the Netherlands, the validation cohort of 264 patients with PSC from the UK...
July 24, 2017: Gut
https://www.readbyqxmd.com/read/28739561/smartphone-based-monitoring-of-objective-and-subjective-data-in-affective-disorders-where-are-we-and-where-are-we-going-systematic-review
#19
Ezgi Dogan, Christian Sander, Xenija Wagner, Ulrich Hegerl, Elisabeth Kohls
BACKGROUND: Electronic mental health interventions for mood disorders have increased rapidly over the past decade, most recently in the form of various systems and apps that are delivered via smartphones. OBJECTIVE: We aim to provide an overview of studies on smartphone-based systems that combine subjective ratings with objectively measured data for longitudinal monitoring of patients with affective disorders. Specifically, we aim to examine current knowledge on: (1) the feasibility of, and adherence to, such systems; (2) the association of monitored data with mood status; and (3) the effects of monitoring on clinical outcomes...
July 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28739448/hydrocortisone-and-ascorbic-acid-synergistically-prevent-and-repair-lps-induced-pulmonary-endothelial-barrier-dysfunction
#20
Nektarios Barabutis, Vikramjit Khangoora, Paul E Marik, John D Catravas
BACKGROUND: Sepsis refers the dysregulated host immune response elicited by microbial infections resulting in life-threatening organ dysfunction. Sepsis represents a medical challenge, since it is associated with a rate of death as high as 60%. Septic shock is strongly associated with vascular dysfunction and elevated pulmonary capillary permeability. We recently reported that the combination of hydrocortisone (HC), ascorbic acid (VitC) and thiamine dramatically improves outcomes and reduces mortality in septic patients...
July 21, 2017: Chest
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