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https://www.readbyqxmd.com/read/27913599/the-effect-of-food-quality-during-growth-on-spatial-memory-consolidation-in-adult-pigeons
#1
M F Scriba, J Gasparini, L Jacquin, C Mettke-Hofmann, N C Rattenborg, A Roulin
Poor environmental conditions experienced during early development can have negative long-term consequences on fitness. Animals can compensate negative developmental effects through phenotypic plasticity by diverting resources from non-vital to vital traits such as spatial memory to enhance foraging efficiency. We tested in young feral pigeons (Columba livia) how diets of different nutritional value during development affect the capacity to retrieve food hidden in a spatially complex environment, a process we refer to as "spatial memory"...
December 2, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27913029/pharmacovigilance-and-biomedical-informatics-a-model-for-future-development
#2
Paul Beninger, Michael A Ibara
PURPOSE: The discipline of pharmacovigilance is rooted in the aftermath of the thalidomide tragedy of 1961. It has evolved as a result of collaborative efforts by many individuals and organizations, including physicians, patients, Health Authorities, universities, industry, the World Health Organization, the Council for International Organizations of Medical Sciences, and the International Conference on Harmonisation. Biomedical informatics is rooted in technologically based methodologies and has evolved at the speed of computer technology...
November 29, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27912210/relative-contributions-of-arterial-stiffness-and-hypertension-to-cardiovascular-disease-the-framingham-heart-study
#3
Teemu J Niiranen, Bindu Kalesan, Naomi M Hamburg, Emelia J Benjamin, Gary F Mitchell, Ramachandran S Vasan
BACKGROUND: The presence and implications of abnormal arterial stiffness, a potential independent predictor of outcomes, in community-dwelling treated hypertensives is unknown. Furthermore, limited data exist regarding the risk of cardiovascular disease (CVD) associated with arterial stiffness across the entire range of blood pressure. METHODS AND RESULTS: We measured carotid-femoral pulse wave velocity (PWV) and classical CVD risk factors in 2127 community-dwelling participants (mean age 60 years, 57% women) of The Framingham Offspring Cohort...
October 26, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27911914/performance-of-the-modified-mini-mental-state-examination-3ms-in-assessing-specific-cognitive-function-in-patients-undergoing-peritoneal-dialysis
#4
Yi Li, Xue Tian, Zu-Ying Xiong, Jin-Lan Liao, Li Hao, Gui-Ling Liu, Ye-Ping Ren, Qin Wang, Li-Ping Duan, Zhao-Xia Zheng, Wen-Xiang Quan, Jie Dong
PURPOSE: While Cognitive impairment (CI) has been identified as an independent risk factors for mortality in patients undergoing peritoneal dialysis (PD), it is inadequately assessed. We evaluated the applicability of the Modified Mini-Mental State Examination (3MS) in assessing specific cognitive function and compared it to a detailed neuropsychological test battery as the reference standard. METHODS: In this multicentric cross-sectional study, we enrolled 445 clinically stable patients from five PD units, who were undergoing PD for at least 3 months...
2016: PloS One
https://www.readbyqxmd.com/read/27911444/impact-of-optical-coherence-tomography-scanning-density-on-quantitative-analyses-in-neovascular-age-related-macular-degeneration
#5
S B Velaga, M G Nittala, R K Konduru, F Heussen, P A Keane, S R Sadda
PurposeTo assess the influence of varying B-scan frame-sampling densities on retinal thickness and volume measurements from spectral domain optical coherence tomography (OCT) in eyes with neovascular age-related macular degeneration (AMD).MethodsVolume OCT data (512 × 128 macular cube over 6 × 6 mm) were collected from 39 eyes with neovascular AMD. All 128 B-scans in each image set were manually segmented, allowing quantification of the neurosensory retina, subretinal fluid (SRF), subretinal hyperreflective material (SRHM), and pigment epithelium detachment (PED)...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27910823/optimized-mlaa-for-quantitative-non-tof-pet-mr-of-the-brain
#6
Didier Benoit, Claes N Ladefoged, Ahmadreza Rezaei, Sune H Keller, Flemming L Andersen, Liselotte Højgaard, Adam E Hansen, Søren Holm, Johan Nuyts
For quantitative tracer distribution in positron emission tomography, attenuation correction is essential. In a hybrid PET/CT system the CT images serve as a basis for generation of the attenuation map, but in PET/MR, the MR images do not have a similarly simple relationship with the attenuation map. Hence attenuation correction in PET/MR systems is more challenging. Typically either of two MR sequences are used: the Dixon or the ultra-short time echo (UTE) techniques. However these sequences have some well-known limitations...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27910113/diagnostic-accuracy-of-faecal-biomarkers-in-detecting-colorectal-cancer-and-adenoma-in-symptomatic-patients
#7
M M Widlak, C L Thomas, M G Thomas, C Tomkins, S Smith, N O'Connell, S Wurie, L Burns, C Harmston, C Evans, C U Nwokolo, B Singh, R P Arasaradnam
BACKGROUND: The diagnosis of colorectal cancer (CRC) can be difficult as symptoms are variable with poor specificity. Thus, there is a quest for simple, non-invasive testing that can help streamline those with significant colonic pathology. AIM: To assess using faecal immunochemical test for haemoglobin (FIT) or faecal calprotectin (FCP) to detect CRC and adenoma in symptomatic patients referred from primary care. METHODS: A total of 799 referred for urgent lower gastrointestinal investigations were prospectively recruited...
December 1, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27909866/the-influence-of-the-bullet-shape-on-the-width-of-abrasion-collars-and-the-size-of-gunshot-entrance-holes
#8
Rebecca Pircher, Demet Preiß, Stefan Pollak, Annette Thierauf-Emberger, Markus Große Perdekamp, Dorothee Geisenberger
To investigate if there is any correlation between the bullet design and the respective dimensions of the abrasion collar and the skin defect in gunshot entrance wounds, experimental studies were performed on dyed pig skin. For the test shots, .38 Special revolver cartridges with three different bullet designs (round nose, wadcutter, and truncated cone) were used. With the help of an image editing program in combination with an image analyzing system, the area size of the abrasion rings and the skin defects was calculated automatically...
December 1, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27909859/sofa-score-and-left-ventricular-systolic-function-as-predictors-of-short-term-outcome-in-patients-with-sepsis
#9
Francesca Innocenti, Vittorio Palmieri, Aurelia Guzzo, Valerio Teodoro Stefanone, Chiara Donnini, Riccardo Pini
In a group of septic patients, we assess the short-term prognostic value of LV systolic performance, evaluated through conventional left ventricular ejection fraction (LVEF) and left ventricular global longitudinal strain (LV GLS). One hundred forty-seven patients with sepsis were recruited; LVEF by planimetry and peak GLS by 2D speckle tracking could be assessed within 24 h. The study population was stratified according to SOFA tertiles assessed at the time of the echocardiogram (G1: SOFA score <5; G2: SOFA score 5-7; G3: SOFA score >7)...
December 1, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27909522/safety-and-necessity-of-thermal-esophageal-probes-during-radiofrequency-ablation-for-the-treatment-of-atrial-fibrillation
#10
Antonio Fasano, Prof Emeritus, Luca Anfuso Md, Stefano Bozzi Md, Claudio Pandozi Prof
BACKGROUND: Radiofrequency ablation is extensively used to achieve pulmonary veins isolation for the cure of atrial fibrillation. Luminal esophageal temperature can be monitored by means of suitable probes to prevent the onset of lesions. OBJECTIVE: To compute the thermal field generated by the ablation, to investigate the interaction between the electromagnetic field and the probe sensors, and to provide a safe interpretation of the temperature detected by the probe, supported by clinical data...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909155/extrapolation-techniques-evaluating-24-hours-of-average-electromagnetic-field-emitted-by-radio-base-station-installations-spectrum-analyzer-measurements-of-lte-and-umts-signals
#11
Stefano Mossetti, Daniela de Bartolo, Ivan Veronese, Marie Claire Cantone, Cristina Cosenza, Elisa Nava
International and national organizations have formulated guidelines establishing limits for occupational and residential electromagnetic field (EMF) exposure at high-frequency fields. Italian legislation fixed 20 V/m as a limit for public protection from exposure to EMFs in the frequency range 0.1 MHz-3 GHz and 6 V/m as a reference level. Recently, the law was changed and the reference level must now be evaluated as the 24-hour average value, instead of the previous highest 6 minutes in a day. The law refers to a technical guide (CEI 211-7/E published in 2013) for the extrapolation techniques that public authorities have to use when assessing exposure for compliance with limits...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27909036/defining-adolescent-common-mental-disorders-using-electronic-primary-care-data-a-comparison-with-outcomes-measured-using-the-cis-r
#12
Rosie P Cornish, Ann John, Andy Boyd, Kate Tilling, John Macleod
OBJECTIVE: To compare the prevalence of common mental disorders (CMDs) derived from data held in primary care records with that measured using the revised Clinical Interview Schedule (CIS-R) in order to assess the potential robustness of findings based only on routinely collected data. DESIGN AND SETTING: Comparison study using linkage between the Avon Longitudinal Study of Parents and Children (ALSPAC) and electronic primary care records. PARTICIPANTS: We studied 1562 adolescents who had completed the CIS-R in ALSPAC at age 17-18 years and had linkage established to their primary care records...
December 1, 2016: BMJ Open
https://www.readbyqxmd.com/read/27908968/psa-stratified-performance-of-18f-and-68ga-labeled-tracers-in-psma-pet-imaging-of-patients-with-biochemical-recurrence-of-prostate-cancer
#13
Felix Dietlein, Carsten Kobe, Stephan Neubauer, Matthias Schmidt, Simone Stockter, Thomas Fischer, Klaus Schomäcker, Axel Heidenreich, Boris D Zlatopolskiy, Bernd Neumaier, Alexander Drzezga, Markus Dietlein
PURPOSE: Several studies outlined the sensitivity of (68)Ga-labeled PET tracers against the prostate-specific membrane antigen (PSMA) for localization of relapsed prostate cancer in patients with renewed increase in the prostate-specific antigen (PSA), commonly referred to as biochemical recurrence. Labeling of PSMA tracers with (18)F offers numerous advantages, including improved image resolution, longer half-life and increased production yields. The aim of this study was to assess the PSA-stratified performance of the (18)F-labeled PSMA tracer (18)F-DCFPyL and the (68)Ga-labeled reference (68)Ga-PSMA-HBED-CC...
December 1, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27908967/kinetic-modeling-of-the-tau-pet-tracer-18f-av-1451-in-human-healthy-volunteers-and-alzheimer-s-disease-subjects
#14
Olivier Barret, David Alagille, Sandra Sanabria, Robert A Comley, Robby M Weimer, Edilio Borroni, Mark Mintun, Nicholas Seneca, Caroline Papin, Thomas Morley, Ken Marek, John P Seibyl, Gilles D Tamagnan, Danna Jennings
: (18)F-AV-1451 is currently the most widely used of several experimental tau PET tracers. The objective of this study was to evaluate (18)F-AV-1451 binding with full kinetic analysis using a metabolite corrected arterial input function, and to compare parameters derived from kinetic analysis with standardized uptake value ratio (SUVR) calculated over different imaging time intervals. METHODS: (18)F-AV-1451 PET brain imaging was completed in 16 subjects: 4 young healthy volunteers (YHV), 4 aged healthy volunteers (AHV) and 8 Alzheimer's disease subjects (AD)...
December 1, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27908840/prescription-opioid-taper-support-for-outpatients-with-chronic-pain-a-randomized-controlled-trial
#15
Mark D Sullivan, Judith A Turner, Cory DiLodovico, Angela D'Appolonio, Kari Stephens, Ya-Fen Chan
Patients receiving long-term opioid therapy for chronic pain and interested in tapering their opioid dose were randomly assigned to a 22-week taper support intervention (psychiatric consultation, opioid dose tapering, and 18 weekly meetings with a physician assistant to explore motivation for tapering and learn pain self-management skills) or usual care (N=35). Assessments were conducted at baseline and 22 and 34 weeks after randomization. Using an intention-to-treat approach, we constructed linear regression models to compare groups at each follow-up...
November 28, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27908505/diagnostic-advantage-of-stress-computed-tomography-myocardial-perfusion-over-single-photon-emission-computed-tomography-for-the-assessment-of-myocardial-ischemia
#16
Yasushi Ueki, Atsushi Izawa, Daisuke Kashiwagi, Shigeki Nishiyama, Shinichi Aso, Chihiro Suzuki, Shumpei Sakurai, Kazuhiro Oguchi, Yoshikazu Yazaki, Uichi Ikeda, Koichiro Kuwahara
BACKGROUND: This study compared adenosine stress computed tomography myocardial perfusion (CTP) with single-photon emission computed tomography (SPECT) in the diagnosis of functionally significant coronary artery stenosis using fractional flow reserve (FFR) as reference standard. METHODS: We included a total of 93 coronary arteries from 31 patients in whom at least one vessel with ≥50% stenosis was detected with computed tomography coronary angiography. All patients underwent both SPECT and adenosine stress CTP, followed by invasive coronary angiography (ICA) and FFR...
November 28, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27908487/mercury-exposure-and-source-tracking-in-distinct-marine-caged-fish-farm-in-southern-china
#17
Xiaoyu Xu, Wen-Xiong Wang
Coasts of South China have experienced an unprecedented growth in its marine-caged fish industry. We analyzed mercury concentrations and stable mercury isotope ratios in fourteen fish species from two cage-cultured farms in Southern China. Total mercury concentrations of all species were lower than the human health screening values, but the human exposures through consumption of several carnivorous fish exceeded the USEPA's reference dose. Isotopic compositions in the sediment (δ(202)Hg: -1.45‰ to -1.23‰; Δ(199)Hg: -0...
November 28, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27908406/trace-element-biomonitoring-in-hair-of-school-children-from-a-polluted-area-by-sector-field-inductively-coupled-plasma-mass-spectrometry
#18
Evgenii J Drobyshev, Nikolay D Solovyev, Natalya B Ivanenko, Maria Yu Kombarova, Alexander A Ganeev
In the current study, a biomonitoring of 18 hair trace elements (Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Ni, Pb, Se, V, Zn, Ca, Na and P) in school children from Leningradskaya Oblast' is reported. A case group, residing in a proximity to the toxic waste disposal grounds (Krasniy Bor), has been assessed vs. controls from a non-urban settlement Seltso. In total, 166 hair samples were analysed using double focusing sector field inductively coupled plasma mass spectrometry after microwave-assisted sample digestion with nitric acid...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27908178/a-probability-based-multi-cycle-sorting-method-for-4d-mri-a-simulation-study
#19
Xiao Liang, Fang-Fang Yin, Yilin Liu, Jing Cai
PURPOSE: To develop a novel probability-based sorting method capable of generating multiple breathing cycles of 4D-MRI images and to evaluate performance of this new method by comparing with conventional phase-based methods in terms of image quality and tumor motion measurement. METHODS: Based on previous findings that breathing motion probability density function (PDF) of a single breathing cycle is dramatically different from true stabilized PDF that resulted from many breathing cycles, it is expected that a probability-based sorting method capable of generating multiple breathing cycles of 4D images may capture breathing variation information missing from conventional single-cycle sorting methods...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27908154/mass-detection-in-digital-breast-tomosynthesis-deep-convolutional-neural-network-with-transfer-learning-from-mammography
#20
Ravi K Samala, Heang-Ping Chan, Lubomir Hadjiiski, Mark A Helvie, Jun Wei, Kenny Cha
PURPOSE: Develop a computer-aided detection (CAD) system for masses in digital breast tomosynthesis (DBT) volume using a deep convolutional neural network (DCNN) with transfer learning from mammograms. METHODS: A data set containing 2282 digitized film and digital mammograms and 324 DBT volumes were collected with IRB approval. The mass of interest on the images was marked by an experienced breast radiologist as reference standard. The data set was partitioned into a training set (2282 mammograms with 2461 masses and 230 DBT views with 228 masses) and an independent test set (94 DBT views with 89 masses)...
December 2016: Medical Physics
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