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https://www.readbyqxmd.com/read/28532118/facile-synthesis-of-polymeric-fluorescent-organic-nanoparticles-based-on-the-self-polymerization-of-dopamine-for-biological-imaging
#1
Yingge Shi, Ruming Jiang, Meiying Liu, Lihua Fu, Guangjian Zeng, Qing Wan, Liucheng Mao, Fengjie Deng, Xiaoyong Zhang, Yen Wei
Polymeric fluorescent organic nanoparticles (polymer-FONs) have raised considerable research attention for biomedical applications owing to their advantages as compared with fluorescent inorganic nanoparticles and small organic molecules. In this study, we presented an efficient, facile and environment-friendly strategy to produce polymer-FONs, which relied on the self-polymerization of dopamine and polyethyleneimine (PEI) in rather mild conditions. To obtain the final polymer-FONs, aldehyde group-containing copolymers (named as poly(UA-co-PEGMA)) were synthesized by reversible addition-fragmentation chain-transfer polymerization using polyethylene glycol methyl ether methacrylate (PEGMA) and 1-undecen-10-al (UA) as monomers...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532094/electrochemical-sensing-of-doxorubicin-in-unprocessed-whole-blood-cell-lysate-and-human-plasma-samples-using-thin-film-of-poly-arginine-modified-glassy-carbon-electrode
#2
Jafar Soleymani, Mohammad Hasanzadeh, Morteza Eskandani, Maryam Khoubnasabjafari, Nasrin Shadjou, Abolghasem Jouyban
A thin film of poly-arginine fabricated on glassy carbon electrode by one step electrodeposition method is applied for detection of doxorubicin hydrochloride in whole blood, cell lysate, and untreated-plasma samples. Cyclic voltammetry results indicated that the doxorubicin is oxidized via two electrons and two protons at physiological pH (pH=7.4) using poly-arginine thin film modified glassy carbon. More importantly, electrostatic repulsion takes place between the prepared polymer film-modified electrode and selected drug resulting in the signal amplification on oxidation of doxorubicin and lowering its over potential and thereby selective detection of doxorubicin in real samples...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532037/multifactor-analysis-on-the-effect-of-collagen-concentration-cross-linking-and-fiber-pore-orientation-on-chemical-microstructural-mechanical-and-biological-properties-of-collagen-type-i-scaffolds
#3
E Suesca, A M A Dias, M E M Braga, H C de Sousa, M R Fontanilla
This work evaluates the effect of processing variables on some physicochemical and mechanical properties of multi- and unidirectional laminar collagen type I scaffolds. The processing variables considered in this study included microstructure orientation (uni- and multidirectional fiber/pore controlled by freeze-drying methodology), cross-linking (chemical - using genipin and glutaraldehyde, and physical - using a dehydrothermal method), and collagen concentration (2, 5 and 8mg/ml). The biocompatibility of the scaffolds obtained in each of the evaluated manufacturing processes was also assessed...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531973/properties-and-toughening-mechanisms-of-pva-pam-double-network-hydrogels-prepared-by-freeze-thawing-and-anneal-swelling
#4
Kangkang Ou, Xia Dong, Chengling Qin, Xinan Ji, Jinxin He
It is well known that preparation method of hydrogels has a significant effect on their properties. In this paper, freeze-thawing and anneal-swelling were applied to prepare poly(vinyl alcohol)/polyacrylamide (PVA/PAM) double-network hydrogels with covalently and physically cross-linked networks. The properties of these hydrogels were investigated and compared to control hydrogels. Results indicated that hydrogels fabricated by freeze-thawing show larger pores size and higher swelling capacity than those made by anneal-swelling and control hydrogels...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531855/investigation-on-the-fast-co-pyrolysis-of-sewage-sludge-with-biomass-and-the-combustion-reactivity-of-residual-char
#5
Shuanghui Deng, Houzhang Tan, Xuebin Wang, Fuxin Yang, Ruijie Cao, Zhao Wang, Renhui Ruan
Gaining the valuable fuels from sewage sludge is a promising method. In this work, the fast pyrolysis characteristics of sewage sludge (SS), wheat straw (WS) and their mixtures in different proportions were carried out in a drop-tube reactor. The combustion reactivity of the residual char obtained was investigated in a thermogravimetric analyzer (TGA). Results indicate that SS and WS at different pyrolysis temperatures yielded different characteristic gas compositions and product distributions. The co-pyrolysis of SS with WS showed that there existed a synergistic effect in terms of higher gas and bio-oil yields and lower char yield, especially at the WS adding percentage of 80wt%...
April 21, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28531841/positive-affective-functioning-in-anhedonic-individuals-daily-life-anything-but-flat-and-blunted
#6
V E Heininga, E Van Roekel, J J Ahles, A J Oldehinkel, A H Mezulis
BACKGROUND: Anhedonia, the decreased interest and pleasure, is often described as 'flat' or 'blunted' positive affect (PA). Yet, little is known about PA functioning in anhedonic individuals' daily lives. The current study investigates PA reactivity to pleasurable experiences in anhedonia together with its relevant temporal dynamics (i.e., variability, instability, and inertia), and expands current knowledge by exploring the role of arousal therein. METHODS: Using the Experience Sampling Method (ESM), we collected 90 assessments of real-life PA experiences across 30 days in 18-24 year old individuals with anhedonia (N=69) and without anhedonia (N=69)...
April 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28531816/predicted-phototoxicities-of-carbon-nano-material-by-quantum-mechanical-calculations
#7
Don Betowski
The purpose of this research was to develop a predictive model for the phototoxicity potential of carbon nanomaterials (fullerenols and single-walled carbon nanotubes). This model is based on the quantum mechanical (ab initio) calculations on these carbon-based materials and comparison of the triplet excited states of these materials to published work relating phototoxicity of polynuclear aromatic hydrocarbons (PAH) to their predictive triplet excited state energy. A successful outcome will add another tool to the arsenal of predictive methods for the U...
March 31, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28531550/barriers-and-facilitators-in-providing-oral-care-to-nursing-home-residents-from-the-perspective-of-care-aides-a-systematic-review-and-meta-analysis
#8
REVIEW
Matthias Hoben, Alix Clarke, Kha Tu Huynh, Nadia Kobagi, Angelle Kent, Huimin Hu, Raissa A C Pereira, Tianyuan Xiong, Kexin Yu, Hongjin Xiang, Minn N Yoon
BACKGROUND: Oral health of nursing home residents is generally poor, with severe consequences for residents' general health and quality of life and for the health care system. Care aides in nursing homes provide up to 80% of direct care (including oral care) to residents, but providing oral care is often challenging. Interventions to improve oral care must tailor to identified barriers and facilitators to be effective. This review identifies and synthesizes the evidence on barriers and facilitators care aides perceive in providing oral care to nursing home residents...
May 11, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28531179/the-gingival-vein-as-a-minimally-traumatic-site-for-multiple-blood-sampling-in-guinea-pigs-and-hamsters
#9
Mariana Valotta Rodrigues, Simone Oliveira de Castro, Cynthia Zaccanini de Albuquerque, Vânia Gomes de Moura Mattaraia, Marcelo Larami Santoro
Laboratory animals are still necessary in scientific investigation and vaccine testing, but while novel methodological approaches are not available for their replacement, the search for new, humane, easy, and painless methods is necessary to diminish their stress and pain. When multiple blood samples are to be collected from hamsters and guinea pigs, the number of available venipuncture sites-which are greatly diminished in these species in comparison with other rodents due to the absence of a long tail-, harasses animal caregivers and researchers...
2017: PloS One
https://www.readbyqxmd.com/read/28531172/experimental-evaluation-of-cryopreservative-solutions-to-maintain-in-vitro-and-in-vivo-infectivity-of-p-berghei-sporozoites
#10
Naresh Singh, Samantha J Barnes, Sandra Kennedy, John H Adams
The rodent malaria parasite Plasmodium berghei is an excellent model organism for laboratory-based experimental evaluation of anti-malarial therapeutics prior to studies with human malaria parasites. The rodent model is especially important for evaluation of pre-erythrocytic (PE) stage therapies, especially as current efforts to develop new PE vaccines and drugs is limited by access to P. falciparum and P. vivax sporozoites. Developing a more effective method for cryopreservation of sporozoites would help improve access to sporozoites for laboratories lacking suitable insectary facilities...
2017: PloS One
https://www.readbyqxmd.com/read/28531125/characterizing-dynamic-walking-patterns-and-detecting-falls-with-wearable-sensors-using-gaussian-process-methods
#11
Taehwan Kim, Jeongho Park, Seongman Heo, Keehoon Sung, Jooyoung Park
By incorporating a growing number of sensors and adopting machine learning technologies, wearable devices have recently become a prominent health care application domain. Among the related research topics in this field, one of the most important issues is detecting falls while walking. Since such falls may lead to serious injuries, automatically and promptly detecting them during daily use of smartphones and/or smart watches is a particular need. In this paper, we investigate the use of Gaussian process (GP) methods for characterizing dynamic walking patterns and detecting falls while walking with built-in wearable sensors in smartphones and/or smartwatches...
May 20, 2017: Sensors
https://www.readbyqxmd.com/read/28530848/splanchnic-thoracoabdominal-and-cerebral-blood-flow-volumes-in-healthy-children-and-young-adults-in-fasting-and-postprandial-states-determining-reference-ranges-by-using-phase-contrast-mr-imaging
#12
Prakash Muthusami, Shi-Joon Yoo, Rajiv Chaturvedi, Navjot Gill, Jonathan Windram, Daryl Schantz, Milan Prsa, Pablo Caro-Dominguez, Mike Seed, Lars Grosse-Wortmann, Simon C Ling, Govind B Chavhan
Purpose To estimate reference ranges for blood flow volume (BFV) in major splanchnic, thoracoabdominal, and neck vessels by using phase-contrast magnetic resonance (MR) imaging in children and young adults in fasting and postprandial states. Materials and Methods In this institutional research ethics board-approved prospective study, healthy volunteers underwent phase-contrast MR imaging in a fasting state and again after a standardized meal. BFV values were reported as medians and ranges, and postmeal to premeal BFV ratios were calculated...
May 22, 2017: Radiology
https://www.readbyqxmd.com/read/28530770/diagnostic-value-of-appendicular-doppler-ultrasonography-in-acute-appendicitis
#13
Hüseyin Uzunosmanoğlu, Yunsur Çevik, Şeref Kerem Çorbacıoğlu, Emine Akıncı, Hakan Buluş, Kadir Ağladıoğlu
BACKGROUND: Acute appendicitis is one of the most common causes of acute abdominal pain prompting emergency department (ED) visits. It is critical for the physicians to promptly and accurately diagnose acute appendicitis. The present study aimed to evaluate the diagnostic efficacy of Doppler ultrasonography (USG) in patients with acute appendicitis and compare this new method with other commonly used radio-diagnostic tools. METHODS: All patients who were diagnosed with acute appendicitis at the Kecioren Training and Research Hospital ED and later underwent appendectomy between October 2012 and April 2013 were included in the study...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28530547/application-of-machine-learning-approaches-for-protein-protein-interactions-prediction
#14
Mengying Zhang, Qiang Su, Yi Lu, Manman Zhao, Bing Niu
BACKGROUND: Proteomics endeavors to study the structures, functions and interactions of proteins. Information of the protein-protein interactions (PPIs) helps to improve our knowledge of the functions and the 3D structures of proteins. Thus determining the PPIs is essential for the study of the proteomics. OBJECTIVE: In this review, in order to study the application of machine learning in predicting PPI, some machine learning approaches such as support vector machine (SVM), artificial neural networks (ANNs) and random forest (RF) were selected, and the examples of its applications in PPIs were listed...
May 22, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28530524/is-real-world-evidence-used-in-p-t-monographs-and-therapeutic-class-reviews
#15
Jason T Hurwitz, Mary Brown, Jennifer S Graff, Loretta Peters, Daniel C Malone
BACKGROUND: Payers are faced with making coverage and reimbursement decisions based on the best available evidence. Often these decisions apply to patient populations, provider networks, and care settings not typically studied in clinical trials. Treatment effectiveness evidence is increasingly available from electronic health records, registries, and administrative claims. However, little is known about when and what types of real-world evidence (RWE) studies inform pharmacy and therapeutic (P&T) committee decisions...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28530515/cost-effectiveness-of-strategies-to-increase-cervical-screening-uptake-at-first-invitation-strategic
#16
Apostolos Tsiachristas, Matthew Gittins, Henry Kitchener, Alastair Gray
Objective To assess the cost-effectiveness of strategies to increase cervical cancer screening uptake at first invitation (STRATEGIC trial). Methods We performed an economic analysis alongside the STRATEGIC trial, comparing each of seven novel interventions for improving cervical screening uptake with control general practices in Greater Manchester and Grampian (United Kingdom). A template was developed to measure the intervention costs. Trial estimates of screening uptake were combined with data from the literature to estimate healthcare costs of each intervention...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28530484/in%C3%A2-vivo-geometry-of-the-kissing-stent-and-covered-endovascular-reconstruction-of-the-aortic-bifurcation-configurations-in-aortoiliac-occlusive-disease
#17
Erik Groot Jebbink, Thijs G Ter Mors, Cornelis H Slump, Robert H Geelkerken, Suzanne Holewijn, Michel Mpj Reijnen
Objectives Various configurations of kissing stent (KS) configurations exist and patency rates vary. In response the covered endovascular reconstruction of the aortic bifurcation configuration was designed to minimize mismatch and improve outcome. The aim of the current study is to compare geometrical mismatch of kissing stent with the covered endovascular reconstruction of the aortic bifurcation configuration in vivo. Methods Post-operative computed tomographic data and patient demographics from 11 covered endovascular reconstruction of the aortic bifurcation and 11 matched kissing stent patients were included...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28530469/rapid-bacterial-detection-during-endodontic-treatment
#18
D B Herzog, N A Hosny, S A Niazi, G Koller, R J Cook, F Foschi, T F Watson, F Mannocci, F Festy
Bacteria present in the root canal (RC) space following an RC treatment (RCT) can lead to persistent infections, resulting in treatment failure and the need for reintervention or extraction. Currently, there are no standardized methods in use to clinically detect bacterial presence within RC spaces. The use of paper point sampling and fluorescence staining was shown to be a rapid method, able to detect residual bacteria following treatment. The study demonstrated that Calcein acetoxymethyl (AM) proved to be a suitable dye for detecting vital bacteria within mature endodontic biofilms, with an improved sensitivity over colony-forming unit counting in a stressed biofilm model...
June 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28530427/a-meta-analytic-review-of-the-association-between-pubertal-timing-and-psychopathology-in-adolescence-are-there-sex-differences-in-risk
#19
Josie M Ullsperger, Molly A Nikolas
Research examining pubertal timing effects on psychopathology has emphasized that a subset of adolescents, particularly females, who experience early pubertal maturation relative to their peers appear to be at increased risk for psychopathology. The aims of the current meta-analysis were (a) to quantify the magnitude of early pubertal timing effects on psychopathology, (b) to examine potential moderators of pubertal timing effects (sex, psychopathology domain, sample composition, measurement method, and mean sample age), and (c) to examine findings in relation to hypotheses in the extant literature explicating differential pubertal timing effects for early versus late youth and males versus females...
May 22, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28530417/effects-of-predictor-weighting-methods-on-incremental-validity
#20
Paul R Sackett, Jeffrey A Dahlke, Oren R Shewach, Nathan R Kuncel
It is common to add an additional predictor to a selection system with the goal of increasing criterion-related validity. Research on the incremental validity of a second predictor is generally based on forming a regression-weighted composite of the predictors. However, in practice predictors are commonly used in ways other than regression-weighted composites, and we examine the robustness of incremental validity findings to other ways of using predictors, namely, unit weighting and multiple hurdles. We show that there are settings in which the incremental value of a second predictor disappears, and can even produce lower validity than the first predictor alone, when these alternatives to regression weighting are used...
May 22, 2017: Journal of Applied Psychology
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