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https://www.readbyqxmd.com/read/28817235/discrepant-hpv-cytology-cotesting-results-are-there-differences-between-cytology-negative-versus-hpv-negative-cervical-intraepithelial-neoplasia
#1
Jessica M Tracht, Antoinette D Davis, Danielle N Fasciano, Isam-Eldin A Eltoum
BACKGROUND: The objective of this study was to compare cervical high-grade squamous intraepithelial lesions subcategorized as cervical intraepithelial neoplasia-3 (CIN-3)-positive after a negative cytology result but positive for high-risk human papillomavirus (HR-HPV) testing to those with a negative HR-HPV test but positive cytology (atypical squamous cells of undetermined significance [ASCUS]-positive/HPV-negative) and to assess reasons for discrepancies. METHODS: The authors retrospectively analyzed women who underwent screening with cytology and HPV testing from 2010 through 2013...
August 17, 2017: Cancer
https://www.readbyqxmd.com/read/28816470/effects-of-postwarning-specificity-on-memory-performance-and-confidence-in-the-eyewitness-misinformation-paradigm
#2
Philip A Higham, Hartmut Blank, Karlos Luna
The influence of postevent misinformation on memory is typically constrained by postwarnings, but little is known about the effectiveness of particular features of postwarnings, such as their specificity. Experiment 1 compared 2 levels of postwarning specificity: A general postwarning just stated the presence of misinformation, whereas a specific postwarning identified the test items for which misinformation had been presented earlier. The specific postwarning, but not the general postwarning, eliminated both the misinformation effect and its deleterious impact on memory monitoring (using a classic 2-alternative forced-choice recognition procedure)...
August 17, 2017: Journal of Experimental Psychology. Applied
https://www.readbyqxmd.com/read/28816149/a-multi-institution-retrospective-analysis-of-cervix-intracavitary-brachytherapy-treatments-part-1-is-eqd2-good-enough-for-reporting-radiobiological-effects
#3
Emma C Fields, Rakhi Melvani, George Hajdok, David D'Souza, Bernard Jones, Kelly Stuhr, Quentin Diot, Christine M Fisher, Nitai Mukhopadhyay, Dorin Todor
PURPOSE: When brachytherapy doses are reported or added, biologically effective dose (BED) minimum dose covering 90% of the volume (D90) is used as if dose is delivered uniformly to the target. Unlike BED(D90), equivalent uniform BED (EUBED) and generalized biologically equivalent uniform dose (gBEUD) are quantities that integrate dose inhomogeneity. Here we compared BED(D90) and equivalent uniform BED (EUBED)/gBEUD in 3 settings: (1) 2 sites using tandem and ovoid (T&O) but different styles of implants; (2) 2 sites using different devices-T&O and tandem and ring (T&R)-and different styles; and (3) the same site using T&O and T&R with the same style...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28815618/effect-on-gene-expression-of-three-allelic-variants-in-gata-motifs-of-abo-rhd-and-rhce-regulatory-elements
#4
Katie Fennell, Roser Hoffman, Ken Yoshida, Sadahiko Iwamoto, Lavendri Govender, Kuben Vather, Ashika Sookraj, Ute Jentsch, Chantale Pambrun, Catherine McAuley, Margaret A Keller, Gorka Ochoa-Garay
BACKGROUND: Only a few genetic variants have been reported in regulatory elements of blood group genes. Most of them affect GATA motifs, binding sites for the GATA-1 transcription factor. STUDY DESIGN AND METHODS: Samples from two patients and one donor with unusual or discrepant serology for ABO, RhD, and RhCE antigens were analyzed by DNA sequencing. Analyzed regions included the coding sequence and portions of regulatory elements. The effect of some variants on gene expression was evaluated in reporter gene assays...
August 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28815543/understanding-the-role-of-lncrnas-in-nervous-system-development
#5
Brian S Clark, Seth Blackshaw
The diversity of lncRNAs has expanded within mammals in tandem with the evolution of increased brain complexity, suggesting that lncRNAs play an integral role in this process. In this chapter, we will highlight the identification and characterization of lncRNAs in nervous system development. We discuss the potential role of lncRNAs in nervous system and brain evolution, along with efforts to create comprehensive catalogues that analyze spatial and temporal changes in lncRNA expression during nervous system development...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28815338/prolonged-hypotension-after-carotid-artery-stenting-incidence-predictors-and-consequences
#6
Elif Gökçal, Elvin Niftaliyev, Çiğdem Deniz, Mehmet Ergelen, Vildan Güzel, Ömer Göktekin, Talip Asil
BACKGROUND: Hemodynamic changes frequently occur after carotid artery stenting (CAS), and in some patients these changes, particularly hypotension, may be prolonged. There are discrepant results for predicting patients at high risk for these prolonged hemodynamic changes and identifying the effect on clinical outcome. In this study, we aimed to determine the frequency, predictors and consequences associated with prolonged hypotension (PH) after CAS in our center. METHODS: We retrospectively analyzed the demographics, risk factors, nature of carotid disease, degree of stenosis of both internal carotid arteries, stent diameter and site of dilatation during stenting in 137 CAS procedures...
August 17, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28815301/keeping-brains-young-with-making-music
#7
Lars Rogenmoser, Julius Kernbach, Gottfried Schlaug, Christian Gaser
Music-making is a widespread leisure and professional activity that has garnered interest over the years due to its effect on brain and cognitive development and its potential as a rehabilitative and restorative therapy of brain dysfunctions. We investigated whether music-making has a potential age-protecting effect on the brain. For this, we studied anatomical magnetic resonance images obtained from three matched groups of subjects who differed in their lifetime dose of music-making activities (i.e., professional musicians, amateur musicians, and non-musicians)...
August 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28815203/transition-to-subspecialty-sign-out-at-an-academic-institution-and-its-advantages
#8
Joanna L Conant, Pamela C Gibson, Janice Bunn, Abiy B Ambaye
Many pathology departments are introducing subspecialty sign-out in surgical pathology. In 2014, the University of Vermont Medical Center transitioned from general sign-out to partial subspecialty sign-out to include gastrointestinal and breast/cervix subspecialty benches; other specimens remained on general benches. Our experiences with the transition are described, including attending pathologist, trainee, support staff, and clinician satisfaction. A survey was e-mailed to all University of Vermont Medical Center anatomic pathology attendings, pathology trainees, pathologist assistants and grossing technicians, and clinicians who send surgical pathology specimens, immediately before and 1 year after transitioning to partial subspecialty sign-out...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28815162/clinical-application-of-ceramics-in-anterior-cervical-discectomy-and-fusion-a-review-and-update
#9
REVIEW
Shayan Abdollah Zadegan, Aidin Abedi, Seyed Behnam Jazayeri, Hirbod Nasiri Bonaki, Alexander R Vaccaro, Vafa Rahimi-Movaghar
STUDY DESIGN: Narrative review. OBJECTIVES: Anterior cervical discectomy and fusion (ACDF) is a reliable procedure, commonly used for cervical degenerative disc disease. For interbody fusions, autograft was the gold standard for decades; however, limited availability and donor site morbidities have led to a constant search for new materials. Clinically, it has been shown that calcium phosphate ceramics, including hydroxyapatite (HA) and tricalcium phosphate (TCP), are effective as osteoconductive materials and bone grafts...
June 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28814223/discrepancies-in-genetic-testing-results-for-coeliac-disease-call-for-standardised-testing-and-reporting
#10
A James M Daveson, Michael Varney, Kate E Jackson, Jason A Tye-Din
No abstract text is available yet for this article.
August 21, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28814125/recreational-drug-use-at-a-major-music-festival-trend-analysis-of-anonymised-pooled-urine
#11
Lotte Christine Groth Hoegberg, Cecilie Christiansen, Jesper Soe, Rasmus Telving, Mette Findal Andreasen, Dan Staerk, Lona Louring Christrup, Kenneth Thermann Kongstad
OBJECTIVE: The spread of new psychoactive substances (NPS) has expanded rapidly in the last decade. The complexity of the pharmacological effects of NPS challenges the traditional treatment guidelines, and information of the emergence of new arrivals is valuable. Our knowledge on the actual range of recreational drugs used and NPS available in Denmark is limited as identification is possible only when consumers become patients in the healthcare system or through drug seizures. We aimed to detect classical recreational drugs and NPS in the urine of music festival attendees and evaluate if the use of NPS could have been predicted by comparing study data with drug seizure data from the previous year published by European and Danish health authorities...
August 17, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28813620/transitioning-from-paper-to-digital-state-statutory-and-regulatory-frameworks-for-health-information-technology
#12
Cason Schmit, Gregory Sunshine, Dawn Pepin, Tara Ramanathan, Akshara Menon, Matthew Penn
OBJECTIVES: In all health system sectors, electronic health information (EHI) is created, used, released, and reused. We examined states' efforts to address EHI uses in law to provide an understanding of the EHI legal environment. METHODS: Attorney researchers used WestlawNext to search for EHI-related statutes and regulations of the US states, US territories, and the District of Columbia in effect as of January 2014. The researchers independently catalogued provisions by the EHI use described in the law...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/28813564/multi-inducer-grouping-for-curve-completion-perceptual-and-computational-exploration
#13
Nir-Cohen Gal, Arad Boaz, Ben-Shahar Ohad
The human visual system excels in object recognition and scene interpretation even in scenes in which some (or even all) observed objects are partially occluded or fragmented. This highly efficient capacity is facilitated by constructive processes of contour completion between inducers to yield the perception of whole objects across gaps. A fundamental problem of the process is when and how the visual system groups different inducers in the visual scene between which completion occurs. Previous studies on this grouping problem, inspired mostly by relatability theory (Kellman & Shipley, 1991), focused on one good continuation condition that dictates whether a given pair of inducers would group together or not...
August 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28813318/gender-and-ptsd-different-pathways-to-a-similar-phenotype
#14
REVIEW
Suzanne L Pineles, Kimberly A Arditte Hall, Ann M Rasmusson
Whereas research supports the existence of a single posttraumatic stress disorder (PTSD) phenotype across women and men, there may be important gender differences in the pathophysiology of, or mechanisms underlying, the disorder. This paper reviews recent literature on gender differences in emotional, cognitive, and neurobiological factors, and their relations with PTSD and relevant comorbidities. Key findings and limitations from both human and animal studies are discussed. Overall, more work is needed that utilizes objective measures in addition to self-report...
April 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28812848/the-elephants-in-the-room-sex-hiv-and-lgbt-populations-in-mena-intersectionality-in-lebanon-comment-on-improving-the-quality-and-quantity-of-hiv-data-in-the-middle-east-and-north-africa-key-challenges-and-ways-forward
#15
Rachel L Kaplan, Cynthia El Khoury
In response to this insightful editorial, we wish to provide commentary that seeks to highlight recent successes and illuminate the often unspoken hurdles at the intersections of culture, politics, and taboo. We focus on sexual transmission and draw examples from Lebanon, where the pursuit of data in quality and quantity is teaching us lessons about the way forward and where we are experiencing many of the challenges referenced in the editorial such as discrepancies between national statistics and rates derived via research as well as the impact of protracted political conflict and displacement...
December 4, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812814/a-comparison-of-iran-and-uk-eq-5d-3l-value-sets-based-on-visual-analogue-scale
#16
Aliasghar A Kiadaliri
BACKGROUND: Preference weights for EQ-5D-3L based on visual analogue scale (VAS) has recently been developed in Iran. The aim of the current study was to compare performance of this value set against the UK VAS-based value set. METHODS: The mean scores for all possible 243 health states were compared using Student t test. Absolute agreement and consistency were investigated using concordance correlation coefficient (CCC) and Bland-Altman plot. Health gains for 29 403 possible transitions between pairs of EQ-5D-3L health states were compared...
September 28, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812212/obesity-treatment-with-botulinum-toxin-a-is-not-effective-a-systematic-review-and-meta-analysis
#17
REVIEW
Fabio Bustamante, Vitor Ottoboni Brunaldi, Wanderley Marques Bernardo, Diogo Turiani H de Moura, Eduardo Turiani H de Moura, Manoel Galvão, Marco Aurélio Santo, Eduardo Guimarães H de Moura
The effectiveness of gastric injections of botulinum toxin-A (BTA) as primary treatment for obesity is not well known since results in literature are discrepant. Hence, we aimed to systematically review and meta-analyze the available data to assess the real effect of BTA therapy. We searched MEDLINE, Embase, Cochrane, SCOPUS, EBSCO, LILACS, and BVS. We considered eligible only randomized controlled trials enrolling obese patients comparing BTA versus saline injections. Our initial search identified 8811 records...
August 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28812133/-watchful-waiting-as-a-therapeutic-principle-for-diseases-of-the-vitreoretinal-interface
#18
REVIEW
H Hoerauf, B Kirchhof
Elective surgery of the vitreoretinal interface is currently the most common reason for vitrectomy in Germany. The evaluation and correct interpretation of spectral domain optical coherence tomography (SD-OCT) images is of great importance but the indications for vitrectomy in macular surgery should be based more on patient symptoms and not only the OCT findings. Watchful waiting is highlighted as an alternative therapeutic option in individual patients. This article addresses a number of aspects and discrepancies between findings and patients' level of suffering based on binocular symptoms...
August 15, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28812095/-working-hour-preferences-of-female-and-male-residents-developments-over-4%C3%A2-years-of-postgraduate-medical-training-in-germany
#19
REVIEW
Stine Ziegler, Lea Krause-Solberg, Martin Scherer, Hendrik van den Bussche
OBJECTIVES: This article addresses developments regarding working hours and working hour preferences of residents undergoing postgraduate training in Germany and analyses if, and for what reasons, full-time or part-time working models are preferred. METHODS: The source of data is the KarMed study, which is based on yearly postal surveys carried out among graduates of the year 2008/2009 from seven medical faculties in Germany. The interviews took place during the entire postgraduate training period...
August 15, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28811929/dual-energy-computed-tomography-angiography-virtual-calcified-plaque-subtraction-in-a-vascular-phantom
#20
Kwang Nam Jin, Jin Wook Chung, Eun-Ah Park, Whal Lee
BACKGROUND: Material decomposition of dual-energy computed tomography (DECT) enables subtraction of calcified plaque. PURPOSE: To evaluate the accuracy of lumen area measurement in calcified plaque by subtraction of DECT and to determine the effect of contrast material concentration, lumen diameter, density, and thickness of calcified plaque for the measurement. MATERIAL AND METHODS: Vessel phantoms were made with six lumen diameters (5.7, 4...
July 2017: Acta Radiologica Open
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