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https://www.readbyqxmd.com/read/28926963/broad-and-inconsistent-muscle-food-classification-is-problematic-for-dietary-guidance-in-the-u-s
#1
REVIEW
Cody L Gifford, Lauren E O'Connor, Wayne W Campbell, Dale R Woerner, Keith E Belk
Dietary recommendations regarding consumption of muscle foods, such as red meat, processed meat, poultry or fish, largely rely on current dietary intake assessment methods. This narrative review summarizes how U.S. intake values for various types of muscle foods are grouped and estimated via methods that include: (1) food frequency questionnaires; (2) food disappearance data from the U.S. Department of Agriculture Economic Research Service; and (3) dietary recall information from the National Health and Nutrition Examination Survey data...
September 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28926600/publication-trends-of-research-on-diabetes-mellitus-and-t-cells-1997-2016-a-20-year-bibliometric-study
#2
Ye Gao, Yiran Wang, Xiao Zhai, Yifei He, Rong Chen, Jingjing Zhou, Ming Li, Qijin Wang
INTRODUCTION: Diabetes Mellitus (DM) is a huge burden for human health. Recent studies show the close relationship between DM and T cells. We investigated the trend in DM and T cells research. METHODS: Using the Web of Science database, we searched the publications on DM and T cells in 1997-2016, and studied the source data using bibliometric methodology. Excel 2016, GraphPad Prism 5, and VOSviewer software were used to analyze the publication trend in DM and T cells research...
2017: PloS One
https://www.readbyqxmd.com/read/28926569/am-i-who-i-say-i-am-unobtrusive-self-representation-and-personality-recognition-on-facebook
#3
Margeret Hall, Simon Caton
Across social media platforms users (sub)consciously represent themselves in a way which is appropriate for their intended audience. This has unknown impacts on studies with unobtrusive designs based on digital (social) platforms, and studies of contemporary social phenomena in online settings. A lack of appropriate methods to identify, control for, and mitigate the effects of self-representation, the propensity to express socially responding characteristics or self-censorship in digital settings, hinders the ability of researchers to confidently interpret and generalize their findings...
2017: PloS One
https://www.readbyqxmd.com/read/28926338/melk-is-not-necessary-for-the-proliferation-of-basal-like-breast-cancer-cells
#4
Hai-Tsang Huang, Hyuk-Soo Seo, Tinghu Zhang, Yubao Wang, Baishan Jiang, Qing Li, Dennis L Buckley, Behnam Nabet, Justin M Roberts, Joshiawa Paulk, Shiva Dastjerdi, Georg E Winter, Hilary McLauchlan, Jennifer Moran, James E Bradner, Michael J Eck, Sirano Dhe-Paganon, Jean J Zhao, Nathanael S Gray
Thorough preclinical target validation is essential for the success of drug discovery efforts. In this study, we combined chemical and genetic perturbants, including the development of a novel selective maternal embryonic leucine zipper kinase (MELK) inhibitor HTH-01-091, CRISPR/Cas9-mediated MELK knockout, a novel chemical-induced protein degradation strategy, RNA interference and CRISPR interference to validate MELK as a therapeutic target in basal-like breast cancers (BBC). In common culture conditions, we found that small molecule inhibition, genetic deletion, or acute depletion of MELK did not significantly affect cellular growth...
September 19, 2017: ELife
https://www.readbyqxmd.com/read/28925975/new-insights-into-the-genome-organization-of-yeast-killer-viruses-based-on-atypical-killer-strains-characterized-by-high-throughput-sequencing
#5
Manuel Ramírez, Rocío Velázquez, Antonio López-Piñeiro, Belén Naranjo, Francisco Roig, Carlos Llorens
Viral M-dsRNAs encoding yeast killer toxins share similar genomic organization, but no overall sequence identity. The dsRNA full-length sequences of several known M-viruses either have yet to be completed, or they were shorter than estimated by agarose gel electrophoresis. High-throughput sequencing was used to analyze some M-dsRNAs previously sequenced by traditional techniques, and new dsRNAs from atypical killer strains of Saccharomyces cerevisiae and Torulaspora delbrueckii. All dsRNAs expected to be present in a given yeast strain were reliably detected and sequenced, and the previously-known sequences were confirmed...
September 19, 2017: Toxins
https://www.readbyqxmd.com/read/28925077/network-wide-screen-identifies-variation-of-novel-precise-on-module-targets-using-conformational-modudaoism
#6
Bing Li, Jun Liu, Yanan Yu, Pengqian Wang, Yingying Zhang, Xumin Ni, Qiong Liu, Xiaoxu Zhang, Zhong Wang, Yongyan Wang
Modular targeting is promising in drug research at network level, but it's challenging to quantificationally identify the precise On-modules. Based on a proposed Modudaoism (MD), we defined conserved MD (MDc) and varied MD (MDv) to quantitatively evaluate the conformational and energy variations of modules, and thereby identify the conserved and discrepant allosteric modules. Compared with the Zsummary , MDc/MDv got an optimized result of module preserved ratio and modular structure. In mice anti-ischemic networks, 3, 5, and 1 conserved allosteric modules as well as 4, 1, and 3 On-modules of baicalin (BA), jasminoidin (JA), and ursodeoxycholic acid (UA) were identified by MDc and MDv, 5 unique allosteric modules and their characteristic actions were revealed...
September 19, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28924611/size-effects-resolve-discrepancies-in-40-years-of-work-on-low-temperature-plasticity-in-olivine
#7
Kathryn M Kumamoto, Christopher A Thom, David Wallis, Lars N Hansen, David E J Armstrong, Jessica M Warren, David L Goldsby, Angus J Wilkinson
The strength of olivine at low temperatures and high stresses in Earth's lithospheric mantle exerts a critical control on many geodynamic processes, including lithospheric flexure and the formation of plate boundaries. Unfortunately, laboratory-derived values of the strength of olivine at lithospheric conditions are highly variable and significantly disagree with those inferred from geophysical observations. We demonstrate via nanoindentation that the strength of olivine depends on the length scale of deformation, with experiments on smaller volumes of material exhibiting larger yield stresses...
September 2017: Science Advances
https://www.readbyqxmd.com/read/28924426/changes-in-the-whole-blood-donor-population-in-south-west-germany-2010-versus-2016
#8
Michael Müller-Steinhardt, Christian Weidmann, Harald Klüter
BACKGROUND: In the recent past, the discrepancy between blood supply and future demand may have been overestimated. As medical progress develops rapidly, it will be essential to monitor ongoing demographic changes in the donor population regularly and to re-evaluate retention and recruiting strategies. The aim of the current study was to compare first-time donor (FTD) characteristics and their return rates. We therefore compared whole blood (WB) donations in total and the annual donation frequencies in 2010 and in 2015/2016...
August 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28924359/brazilian-orthopedists-opinions-and-perceptions-on-femoroacetabular-impingement
#9
Leandro Ejnisman, Moin Khan, Olufemi Rolland Ayeni, Mohit Bhandari, Helder de Souza Miyahara, Jose Ricardo Negreiros Vicente
OBJECTIVE: To assess the opinion of Brazilian orthopedists surgeons on the diagnosis and treatment of femoroacetabular impingement (FAI). METHODS: A questionnaire was sent to several orthopedic societies around the world, including the Sociedade Brasileira de Ortopedia e Traumatologia (SBOT). This questionnaire was sent electronically and included questions on many topics related to FAI. RESULTS: 253 Brazilian orthopedists responded the questionnaire...
November 2016: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28924095/a-comparative-study-of-reference-dosimetries-in-japan-and-canada
#10
Toru Kawachi, Tetsurou Katayose, Takumi Kodama, Ryouhei Miyasaka, Morihito Shimizu, Hidetoshi Saitoh
In Japan and North America, different dosimetry protocols have been implemented to determine the absorbed dose to water: JSMP Standard Dosimetry 12 and AAPM TG-51 addendum. In this study, Japanese and Canadian reference dosimetries for high energy photon beams were compared theoretically, and then they were verified experimentally. We estimated the theoretical differences of the ion recombination correction factors, the leakage correction factors, the radial dose distribution correction factors, the calibration factors, the beam quality correction factors and the absorbed dose to water...
2017: Japanese Journal of Medical Physics
https://www.readbyqxmd.com/read/28923686/high-speed-video-analysis-improves-the-accuracy-of-spinal-cord-compression-measurement-in-a-mouse-contusion-model
#11
Marion Fournely, Yvan Petit, Éric Wagnac, Jérôme Laurin, Virginie Callot, Pierre-Jean Arnoux
BACKGROUND: Animal models of spinal cord injuries aim to utilize controlled and reproducible conditions. However, a literature review reveals that mouse contusion studies using equivalent protocols may show large disparities in the observed impact force vs. cord compression relationship. The overall purpose of this study was to investigate possible sources of bias in these measurements. The specific objective was to improve spinal cord compression measurements using a video-based setup to detect the impactor-spinal cord time-to-contact...
September 15, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28923462/competing-perspectives-on-frames-of-reference-in-language-and-thought
#12
Peggy Li, Linda Abarbanell
A study found that Dutch-speaking children who prefer an egocentric (left/right) reference frame when describing spatial relationships, and Hai||om-speaking children who use a geocentric (north/south) frame had difficulty recreating small-scale spatial arrays using their language-incongruent system (Haun, Rapold, Janzen, & Levinson, 2011). In five experiments, we reconciled these results with another study showing that English (egocentric) and Tseltal Mayan (geocentric) speakers can flexibly use both systems (Abarbanell, 2010; Li, Abarbanell, Gleitman, & Papafragou, 2011)...
September 15, 2017: Cognition
https://www.readbyqxmd.com/read/28923376/visuo-spatial-construction-trajectories-in-fragile-x-syndrome-fxs-and-autism-spectrum-disorders-asd-evidence-of-cognitive-heterogeneity-within-neurodevelopmental-conditions
#13
Carrie J Ballantyne, María Núñez, Kallia Manoussaki
BACKGROUND/AIMS: There have been discrepancies reported in visuo-spatial construction ability in children with Autism Spectrum Disorders (ASD), fragile X Syndrome (FXS) and those with a comorbid diagnosis of FXS and ASD (AFXS). This study aimed to provide a better understanding of the visuo-spatial processing styles in these heterogeneous neurodevelopmental disorders. METHODS AND PROCEDURE: Navon-type tasks were used to assess visuo-spatial construction ability across 5 groups of children: typically developing, FXS, AFXS, ASD children who scored low-moderate (HFA) and ASD children that scored severe (LFA) on the Childhood Autism Rating Scale (CARS)...
September 15, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28923278/can-adjunctive-therapies-augment-the-efficacy-of-endovascular-thrombolysis-a-potential-role-for-activated-protein-c
#14
REVIEW
Arun Paul Amar, Abhay P Sagare, Zhen Zhao, Yaoming Wang, Amy R Nelson, John H Griffin, Berislav V Zlokovic
In the management of acute ischemic stroke, vessel recanalization correlates with functional status, mortality, cost, and other outcome measures. Thrombolysis with intravenous tissue plasminogen activator has many limitations that restrict its applicability, but recent advances in the development of mechanical thrombectomy devices as well as improved systems of stroke care have resulted in greater likelihood of vessel revascularization. Nonetheless, there remains substantial discrepancy between rates of recanalization and rates of favorable outcome...
September 15, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28923058/a-model-of-plasmodium-vivax-concealment-based-on-plasmodium-cynomolgi-infections-in-macaca-mulatta
#15
Luis L Fonseca, Chester J Joyner, Mary R Galinski, Eberhard O Voit
BACKGROUND: Plasmodium vivax can cause severe malaria. The total parasite biomass during infections is correlated with the severity of disease but not necessarily quantified accurately by microscopy. This finding has raised the question whether there could be sub-populations of parasites that are not observed in peripheral blood smears but continue to contribute to the increase in parasite numbers that drive pathogenesis. Non-human primate infection models utilizing the closely related simian malaria parasite Plasmodium cynomolgi hold the potential for quantifying the magnitude of possibly unobserved infected red blood cell (iRBC) populations and determining how the presence of this hidden reservoir correlates with disease severity...
September 18, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28922838/comparative-genomics-of-a-drug-resistant-pseudomonas-aeruginosa-panel-and-the-challenges-of-antimicrobial-resistance-prediction-from-genomes
#16
J Jeukens, I Kukavica-Ibrulj, J G Emond-Rheault, L Freschi, R C Levesque
Antimicrobial resistance (AMR) is now recognized as a global threat to human health. The accessibility of microbial whole-genome sequencing offers an invaluable opportunity for resistance surveillance via the resistome, i.e. the genes and mutations underlying AMR. Unfortunately, AMR prediction from genomic data remains extremely challenging, especially for species with a large pan-genome. One such organism, for which multidrug-resistant (MDR) isolates are frequently encountered in the clinic, is Pseudomonas aeruginosa...
October 2, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28922317/medical-genetic-services-in-a-developing-country-lesson-from-thailand
#17
Chanin Limwongse
PURPOSE OF REVIEW: To give an example of how advances in medical genetics impact a developing country and how Thailand struggle to improve medical genetics services. RECENT FINDINGS: Thailand is an example of developing country with limited resources, low geneticist to population ratio, formally decentralized even though practically centralized healthcare system and growing public interest in medical genetic technology. Nonetheless, efforts have been and still being made in regard to expanding clinical genetics services, improving access to laboratory diagnosis, increasing rare disease medication in national formulary, and training of medical genetics personnel...
September 16, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28922293/the-role-of-vitamin-d-in-cancer-cachexia
#18
Fabio Penna, Andrea Camperi, Maurizio Muscaritoli, Nicoletta Filigheddu, Paola Costelli
PURPOSE OF REVIEW: The possibility to use vitamin D supplementation to improve muscle wasting, with particular focus on cancer cachexia, is discussed. RECENT FINDINGS: Vitamin D exerts biological actions on myogenic precursor proliferation and differentiation, impinging on muscle regeneration. However, the effects of VitD supplementation in diseases associated with muscle atrophy, such as cancer cachexia, are poorly investigated. Data obtained in experimental models of cancer cachexia show that the administration of vitamin D to tumor-bearing animals is not able to prevent or delay both muscle wasting and adipose tissue depletion, despite increased expression of muscle vitamin D receptor...
September 15, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28922257/endoscopic-and-histological-assessment-of-paediatric-inflammatory-bowel-disease-over-a-three-year-follow-up-period
#19
J J Ashton, Q Bonduelle, E Mossotto, T Coelho, A Batra, N A Afzal, B Vadgama, S Ennis, R M Beattie
OBJECTIVES: Discrepancies between Inflammatory bowel disease (IBD) endoscopic/histological extent are documented at diagnosis. It is unclear whether these differences persist through disease course, with potential impact on categorisation and management. We aimed to analyse the progression of disease over a 3-year period. METHODS: Patients aged < 17 years, diagnosed between 2010-2013 at Southampton Children's Hospital and followed-up for 3 years were eligible...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28921995/the-angel-and-the-devil-on-your-shoulder-friends-mitigate-and-exacerbate-21st-birthday-alcohol-related-consequences
#20
Jennifer Fillo, Lindsey M Rodriguez, Amber M Anthenien, Clayton Neighbors, Christine M Lee
Twenty-first birthdays are associated with heavier drinking and more negative consequences than any other high-risk drinking event. Friends are the strongest social influence on young adult drinking; however, previous research on college students' drinking has often only examined individuals' perceptions of "friends" generally. Unfortunately, this may obscure the positive influence of some friends and the negative influence of others. Using data drawn from a larger intervention study aimed at reducing 21st birthday drinking, this research examined how specific friends (N = 166) who were present at 21st birthday celebrations may have exacerbated or mitigated celebrants' (N = 166) experience of alcohol-related consequences, as well as how characteristics of that friendship moderate these effects...
September 18, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
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