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https://www.readbyqxmd.com/read/28088725/risk-management-financial-evaluation-and-funding-for-wastewater-and-stormwater-reuse-projects
#1
Casey Furlong, Saman De Silva, Kein Gan, Lachlan Guthrie, Robert Considine
This paper has considered risk management, financial evaluation and funding in seven Australian wastewater and stormwater reuse projects. From the investigated case studies it can be seen that responsible parties have generally been well equipped to identify potential risks. In relation to financial evaluation methods some serious discrepancies, such as time periods for analysis, and how stormwater benefits are valued, have been identified. Most of the projects have required external, often National Government, funding to proceed...
January 12, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28087769/enzyme-efficiency-but-not-thermostability-drives-cefotaxime-resistance-evolution-in-tem-1-%C3%AE-lactamase
#2
Jennifer Knies, Fei Cai, Daniel M Weinreich
A leading intellectual challenge in evolutionary genetics is to identify the specific phenotypes that drive adaptation. Enzymes offer a particularly promising opportunity to pursue this question, because many enzymes' contributions to organismal fitness depend on a comparatively small number of experimentally accessible properties. Moreover, on first principles the demands of enzyme thermostability stand in opposition to the demands of catalytic activity. This observation, coupled with the fact that enzymes are only marginally thermostable, motivates the widely held hypothesis that mutations conferring functional improvement require compensatory mutations to restore thermostability...
January 12, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28080963/is-the-cardiac-monitoring-function-related-to-the-self-in-both-the-default-network-and-right-anterior-insula
#3
Mariana Babo-Rebelo, Nicolai Wolpert, Claude Adam, Dominique Hasboun, Catherine Tallon-Baudry
The self has been proposed to be rooted in the neural monitoring of internal bodily signals and might thus involve interoceptive areas, notably the right anterior insula (rAI). However, studies on the self consistently showed the involvement of midline default network (DN) nodes, without referring to visceral monitoring. Here, we investigate this apparent discrepancy. We previously showed that neural responses to heartbeats in the DN encode two different self-dimensions, the agentive 'I' and the introspective 'Me', in a whole-brain analysis of magnetoencephalography (MEG) data...
November 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28080054/bond-dissociation-energies-for-diatomic-molecules-containing-3d-transition-metals-benchmark-scalar-relativistic-coupled-cluster-calculations-for-twenty-molecules
#4
Lan Cheng, Jürgen Gauss, Branko Ruscic, Peter B Armentrout, John F Stanton
Benchmark scalar-relativistic coupled-cluster calculations for dissociation energies of the twenty diatomic molecules containing 3d transition metals in the 3dMLBE20 database (Xu et al., J. Chem. Theory Comput. 2015, 11, 2036) ) are reported. Electron correlation and basis set effects are systematically studied. The agreement between theory and experiment is in general satisfactory. For a subset of sixteen molecules, the standard deviation between computational and experimental values is 9 kJ/mol with the maximum deviation being 15 kJ/mol...
January 12, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28079800/discrepancy-between-financial-disclosures-of-authors-of-clinical-practice-guidelines-and-reports-by-industry
#5
Nikolaos Andreatos, Ioannis M Zacharioudakis, Fainareti N Zervou, Maged Muhammed, Eleftherios Mylonakis
There is a substantial effort to increase the accuracy of conflicts of interest (COI) reporting, and reduce the influence of COI between physicians and industry, especially as it relates to clinical practice guidelines.We used the newly implemented Open Payments dataset to evaluate the accuracy of COI disclosures of authors of clinical practice guidelines that were either newly published or revised within 2014 and were included in the National Guideline Clearinghouse (NGC) website (maintained by the U.S. Department of Health and Human Services)...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079237/celiac-disease-prevalence-is-not-increased-in-patients-with-functional-dyspepsia
#6
Juan Lasa, Liliana Spallone, Silvina Gandara, Elsa Chaar, Saul Berman, David Zagalsky
BACKGROUND: - Previous evidence trying to assess the risk of celiac disease among dyspeptic patients has been inconclusive, showing in some cases notorious discrepancies. OBJECTIVE: - To determine the prevalence of celiac disease in patients with dyspepsia compared to healthy controls without dyspepsia. METHODS: - Adult patients under evaluation for dyspepsia were invited to participate. These patients were offered an upper gastrointestinal endoscopy with duodenal biopsies...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28078322/diagnostic-dilemma-in-discordant-thyroid-function-tests-due-to-thyroid-hormone-autoantibodies
#7
Panudda Srichomkwun, Neal H Scherberg, Jasminka Jakšić, Samuel Refetoff
OBJECTIVE: Assay interference could be the cause of abnormal thyroid function tests. Early recognition prevents inappropriate patient management. The objective of this report is to present a case with discordant thyroid function tests in different thyroid assay platforms due to thyroid autoantibodies. METHODS: We present a case her family, laboratory data and methods that investigate immunoassay interference. RESULTS: A 21-year-old woman with autoimmune thyroid disease was treated for hypothyroidism with levothyroxine and noted to have elevated total and free thyroxine, free triiodothyronine but normal thyroid-stimulating hormone...
2017: AACE Clin Case Rep
https://www.readbyqxmd.com/read/28077627/a-feasibility-study-on-the-use-of-phantoms-with-statistical-lung-masses-for-determining-the-uncertainty-in-the-dose-absorbed-by-the-lung-from-broad-beams-of-incident-photons-and-neutrons
#8
Atiyeh Ebrahimi Khankook, Hashem Miri Hakimabad, Laleh Rafat Motavalli
Computational models of the human body have gradually become crucial in the evaluation of doses absorbed by organs. However, individuals may differ considerably in terms of organ size and shape. In this study, the authors sought to determine the energy-dependent standard deviations due to lung size of the dose absorbed by the lung during external photon and neutron beam exposures. One hundred lungs with different masses were prepared and located in an adult male International Commission on Radiological Protection (ICRP) reference phantom...
January 10, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28077337/stress-hormone-epinephrine-adrenaline-and-norepinephrine-noradrenaline-effects-on-the-anaerobic-bacteria
#9
REVIEW
Lyudmila Boyanova
Microbial endocrinology is a relatively new research area that already encompasses the anaerobes. Stress hormones, epinephrine and norepinephrine, can affect the growth of anaerobic bacteria such as Fusobacterium nucleatum, Prevotella spp., Porhyromonas spp., Tanerella forsythia and Propionibacterium acnes and can increase virulence gene expression, iron acquisition and many virulence factors of some anaerobic species such as Clostridium perfringens, Porphyromonas gingivalis and Brachyspira pilosicoli. Epinephrine and norepinephrine effects can lead to a growth increase or decrease, or no effect on the growth of the anaerobes...
January 8, 2017: Anaerobe
https://www.readbyqxmd.com/read/28076962/role-of-post-mapping-computed-tomography-in-virtual-assisted-lung-mapping
#10
Masaaki Sato, Kazuhiro Nagayama, Hideki Kuwano, Jun-Ichi Nitadori, Masaki Anraku, Jun Nakajima
Background Virtual-assisted lung mapping is a novel bronchoscopic preoperative lung marking technique in which virtual bronchoscopy is used to predict the locations of multiple dye markings. Post-mapping computed tomography is performed to confirm the locations of the actual markings. This study aimed to examine the accuracy of marking locations predicted by virtual bronchoscopy and elucidate the role of post-mapping computed tomography. Methods Automated and manual virtual bronchoscopy was used to predict marking locations...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28076957/collapse-precedes-folding-in-denaturant-dependent-assembly-of-ubiquitin
#11
Govardhan Reddy, Dave Thirumalai
The folding of small protein Ubiquitin (Ub), which plays an indispensable role in targeting proteins for degradation and DNA damage response is complex. A number of experiments on Ub folding have reached differing conclusions regarding the relation between collapse and folding, and whether intermediates are populated. In order to resolve these vexing issues, we elucidate the denaturant-dependent thermodynamics and kinetics of Ub folding at low and neutral pH as a function of Guanidinium chloride and Urea using coarse-grained molecular simulations...
January 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28076806/measurement-of-slow-spontaneous-release-of%C3%A2-11-cis-retinal-from-rhodopsin
#12
He Tian, Thomas P Sakmar, Thomas Huber
The vertebrate visual photoreceptor rhodopsin (Rho) is a unique G protein-coupled receptor as it utilizes a covalently tethered inverse agonist (11-cis-retinal) as the native ligand. Previously, electrophysiological studies showed that ligand binding of 11-cis-retinal in dark-adapted Rho was essentially irreversible with a half-life estimated to be 420 years, until after thermal isomerization to all-trans-retinal, which then slowly dissociates. This long lifetime of 11-cis-retinal binding was considered to be physiologically important for minimizing background signal (dark noise) of the visual system...
January 10, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28076751/salter-harris-type-iv-fracture-of-the-proximal-phalanx-of-the-thumb-with-rotation-of-the-epiphysis-outcome-10-years-following-open-reduction-and-k-wire-fixation
#13
Mohammad M Al-Qattan
INTRODUCTION: Salter-Harris type IV fracture of the proximal phalanx with 90° rotation of the epiphysis is very rare. We report on a case of Salter-Harris type IV fracture of the proximal phalanx of the thumb with rotation of the epiphysis and document the outcome 10 years after surgery. PRESENTATION OF CASE: A 5-year old boy presented with Salter-Harris type IV fracture of the thumb with 90° rotation of the epiphysis. Open reduction and K-wire fixation was done...
December 27, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28076669/medication-discrepancies-at-outpatient-departments-for-mood-and-anxiety-disorders-in-the-netherlands-risks-and-clinical-relevance
#14
Mirjam Simoons, Hans Mulder, Arne J Risselada, Frederik W Wilmink, Robert Schoevers, Henricus G Ruhé, Eric N van Roon
OBJECTIVE: To identify discrepancies between actual drug use by outpatients with mood and anxiety disorders and medication overviews from health care providers as well as to investigate the clinical relevance of those discrepancies. METHODS: A cross-sectional study in adults visiting 1 of 4 participating outpatient departments for mood and anxiety disorders was conducted between March and November 2014. DSM-5 criteria were used to assign the psychiatric diagnosis...
November 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28076538/comparative-study-of-satisfaction-of-users-and-health-professionals-with-the-public-dental-service
#15
Danielle Bordin, Cristina Berger Fadel, Suzely Adas Saliba Moimaz, Cléa Adas Saliba Garbin, Nemre Adas Saliba
The objective was to confront the view of users and health professionals about the satisfaction with the public dental service. Interviews were conducted with users, professionals considered directly (ESB) and indirectly (ACS) involved in oral health. Variables were evaluated individually and grouped into domains. A score was created for the analysis and the Kruskal-Wallis test was applied. The respondents positively assessed the quality of the dental services. The ACS demonstrated less satisfaction compared to users regarding general satisfaction in the Physical Structure and Medical Care domains and the variables: quality of clinical care; guidance to the patient after treatment performed in the specialty; and period of dental care...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28076332/lysosomal-acid-phosphatase-2-is-an-unfavorable-prognostic-factor-but-is-associated-with-better-survival-in-stage-ii-colorectal-cancer-patients-receiving-chemotherapy
#16
Yu-Chieh Lee, Chia-Yu Su, Yuan-Feng Lin, Chun-Mao Lin, Chih-Yeu Fang, Yen-Kuang Lin, Michael Hsiao, Chi-Long Chen
Colorectal cancer (CRC) is one of the leading cancers worldwide. Surgery is the main therapeutic modality for stage II CRC. However, the implementation of adjuvant chemotherapy remains controversial and is not universally applied so far. In this study, we found that the protein expression of lysosomal acid phosphatase 2 (ACP2) was increased in CRC and that stage II CRC patients with high ACP2 expression showed a poorer outcome than those with low ACP2 expression (p = 0.004). To investigate this discrepancy, we analyzed the relation between ACP2 expression and several clinical cofactors...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28076298/comparison-of-abbott-realtime-genotype-ii-genematrix-restriction-fragment-mass-polymorphism-and-sysmex-hiscl-hcv-gr-assays-for-hepatitis-c-virus-genotyping
#17
Mi-Soon Han, Yongjung Park, Hyon-Suk Kim
BACKGROUND: Hepatitis C virus (HCV) genotype is a predictive marker for treatment response. We sequentially evaluated the performances of two nucleic acid amplification tests (NAATs) and one serology assay for HCV genotype: Abbott RealTime genotype II (RealTime II), GeneMatrix restriction fragment mass polymorphism (RFMP), and Sysmex HISCL HCV Gr (HISCL Gr). METHODS: We examined 281 clinical samples with three assays. The accuracy was assessed using the HCV Genotype Performance Panel PHW204 (SeraCare Life Sciences) for two NAATs...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28075436/gait-kinematic-deviations-in-patients-with-developmental-dysplasia-of-the-hip-treated-with-total-hip-arthroplasty
#18
Yong Nie, Ning Ning, Fuxing Pei, Bin Shen, Zongke Zhou, Zongming Li
Comprehensive gait analysis of patients with Crowe type II and III developmental dysplasia of the hip (DDH) after successful total hip arthroplasty (THA) is lacking in the literature. This study evaluated gait function in joint kinematics after unilateral and bilateral THA in patients with DDH. In addition, the effect of high cup position on gait function was investigated. A total of 16 unilateral and 15 bilateral cementless THA patients due to DDH and 10 healthy participants comprised the study population...
January 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/28075218/the-relationship-between-stroke-survivors-perceived-identity-and-mood-self-esteem-and-quality-of-life
#19
Irina Lapadatu, Reg Morris
OBJECTIVES: To examine change in identity after stroke and to elucidate its relationship with mood and quality of life. To test Higgins' theory of the impact of identity (self-discrepancy) on anxiety and depression. To examine the role of self-esteem in mediating the relationship between identity and outcomes. METHOD: Sixty-five community-living first-time stroke survivors, mean age 61.58 and time since stroke 5.60 years, were recruited from stroke charities. A cross-sectional study used the Head Injury Semantic Differential Scale, the Hospital Anxiety and Depression Scale, the Rosenberg Self-Esteem Scale, the Stroke-Specific Quality of Life Questionnaire (adapted) and the Barthel Index...
January 11, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28074941/enhancing-the-detection-of-dysmorphic-red-blood-cells-and-renal-tubular-epithelial-cells-with-a-modified-urinalysis-protocol
#20
Yu Chu-Su, Kenichi Shukuya, Takashi Yokoyama, Wei-Chou Lin, Chih-Kang Chiang, Chii-Wann Lin
Urinary sediment is used to evaluate patients with possible urinary tract diseases. Currently, numerous protocols are applied to detect dysmorphic red blood cells (RBCs) and renal tubular epithelial cells (RTECs) in urinary sediment. However, distinct protocols are used by nephrologists and medical technologists for specimen concentration and observation, which leads to major discrepancies in the differential counts of formed elements such as dysmorphic RBCs and RTECs and might interfere with an accurate clinical diagnosis...
January 11, 2017: Scientific Reports
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