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Retinal angiography

Qian Wang, Szy Yann Chan, Yanni Yan, Jingyan Yang, Wenjia Zhou, Jost B Jonas, Wen Bin Wei
PURPOSE: To examine the vascular density in different retinal layers and in the choriocapillaris in eyes with retinal vein occlusions (RVO). METHODS: Applying optical coherence tomography angiography (OCTA), we examined patients with unilateral RVOs and normal individuals of a control group. RESULTS: The study group included 48 patients with unilateral RVO and the control group 17 normal individuals. Eyes affected by RVO as compared to the contralateral unaffected eyes (all P < 0...
June 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Chikako Hara, Taku Wakabayashi, Hiroshi Toyama, Yoko Fukushima, Kaori Sayanagi, Shigeru Sato, Hirokazu Sakaguchi, Kohji Nishida
PURPOSE: To investigate the frequency and patient characteristics that influence anatomic response of intravitreal aflibercept in treatment-naïve neovascular age-related macular degeneration (AMD). DESIGN: Retrospective, interventional, consecutive case series. METHODS: Three hundred and sixty-five eyes of 365 patients with AMD who underwent 3 monthly intravitreal aflibercept treatments with follow-up for at least 12 months were investigated...
June 15, 2018: British Journal of Ophthalmology
Sasan Moghimi, Linda M Zangwill, Rafaella C Penteado, Kyle Hasenstab, Elham Ghahari, Huiyuan Hou, Mark Christopher, Adeleh Yarmohammadi, Patricia Isabel C Manalastas, Takuhei Shoji, Christopher Bowd, Robert N Weinreb
PURPOSE: To investigate prospectively the relationship between macular and peripapillary vessel density and progressive retinal nerve fiber layer (RNFL) loss in patients with mild to moderate primary open-angle glaucoma. DESIGN: Prospective, observational study. PARTICIPANTS: One hundred thirty-two eyes of 83 patients with glaucoma followed up for at least 2 years (average: 27.3±3.36 months). METHODS: Measurements of macular whole image vessel density (m-wiVD) and optic nerve head whole image vessel density (onh-wiVD) were acquired at baseline using OCT angiography...
June 12, 2018: Ophthalmology
Fumitaka Hirose, Junichi Kiryu, Yasuhiko Tabata, Hiroshi Tamura, Kunihiro Musashi, Noriaki Takase, Hideaki Usui, Soichiro Kuwayama, Aki Kato, Nagahisa Yoshimura, Yuichiro Ogura, Tsutomu Yasukawa
Proliferative vitreoretinopathy (PVR) is a challenging pathological condition, often causing failure of retinal detachment surgery. The purpose of this study was to evaluate the feasibility of a delivery system of bioactive proteins using anionic and cationic gelatin microspheres and to establish a new PVR model in rabbits by intraocular sustained delivery of basic fibroblast growth factor (bFGF) and interferon-beta (IFNβ). Anionic and cationic gelatin microspheres were prepared and immersed in bFGF and IFNβ solution, respectively, to yield a polyion complex between gelatin matrix and a bioactive protein...
June 12, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Mariana Ingolotti, Enrique Alfonso Roig Melo-Granados, Pedro Mario González-Madrigal, Humberto Ruiz García
PURPOSE: To report a case of central retinal artery occlusion in a patient with macular telangiectasia Type 2 using multimodal imaging. METHODS: Observational case report. RESULTS: A 58-year-old woman who presented with acute painless unilateral vision loss was diagnosed with central retinal artery occlusion in her right eye with macular telangiectasia Type 2 findings in both eyes. Fundus examination revealed retinal whitening with unusual cherry-red spot plus small crystalline deposits in the temporal macula...
June 13, 2018: Retinal Cases & Brief Reports
Thomas S Hwang, Ahmed M Hagag, Jie Wang, Miao Zhang, Andrew Smith, David J Wilson, David Huang, Yali Jia
Importance: Diabetic retinopathy (DR) is a leading cause of vision loss that is managed primarily through qualitative clinical examination of the retina. Optical coherence tomography angiography (OCTA) may offer an objective and quantitative method of evaluating DR. Objective: To quantify capillary nonperfusion in 3 vascular plexuses in the macula of eyes patients with diabetes of various retinopathy severity using projection-resolved OCTA (PR-OCTA). Design, Setting, and Participants: Cross-sectional study at a tertiary academic center comprising 1 eye each from healthy control individuals and patients with diabetes at different severity stages of retinopathy...
June 14, 2018: JAMA Ophthalmology
Jing-Yu Min, Yanan Lv, Suqin Yu, Yuan-Yuan Gong
PURPOSE: The present study analyzed the appearances of optical coherence tomography angiography (OCTA) in patients with central serous chorioretinopathy (CSC) based on fluorescein angiography (FA) and indocyanine green angiography (ICGA). METHOD: In the current case series, 54 eyes of 50 patients diagnosed as CSC were evaluated retrospectively. OCTA, FA, and ICGA were performed on each patient. Two trained observers examined the OCTA images independently to confirm and compare the choriocapillary appearance with that on FA/ICGA...
June 12, 2018: Lasers in Surgery and Medicine
Ma Ludivina Robles-Osorio, Renata García-Franco, Carlos D Núñez-Amaro, Ximena Mira-Lorenzo, Paulina Ramírez-Neria, Wendy Hernández, Ellery López-Star, Thomas Bertsch, Gonzalo Martínez de la Escalera, Jakob Triebel, Carmen Clapp
Background: Diabetic retinopathy (DR) and diabetic macular edema (DME) are potentially blinding, microvascular retinal diseases in people with diabetes mellitus. Preclinical studies support a protective role of the hormone prolactin (PRL) due to its ocular incorporation and conversion to vasoinhibins, a family of PRL fragments that inhibit ischemia-induced retinal angiogenesis and diabetes-derived retinal vasopermeability. Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride...
2018: Frontiers in Endocrinology
Tomoaki Murakami, Kiyoshi Suzuma, Yoko Dodo, Tatsuya Yoshitake, Shota Yasukura, Hideo Nakanishi, Masahiro Fujimoto, Maho Oishi, Akitaka Tsujikawa
Diabetic hyperreflective foci in the outer retinal layers are a clinically relevant finding on optical coherence tomography (OCT) images, although their characteristics remain to be elucidated. Here we investigated the decorrelation signal around hyperreflective foci on OCT angiography (OCTA) images in diabetic retinopathy (DR). We retrospectively reviewed sufficient quality OCTA images from 102 eyes of 66 patients that were obtained using split-spectrum amplitude-decorrelation angiography algorithm. Most confluent hyperreflective foci were randomly deposited or appeared in a radiating array on the en-face structural OCT images in the inner nuclear layer (INL) or Henle's fiber layer (HFL), respectively...
June 11, 2018: Scientific Reports
Chetan Kantibhai Patel, Miranda Buckle
This article explores the development of retinal imaging, with particular emphasis on ultra-widefield imaging and the key concept of field of view. Two ultra-widefield imaging platforms are examined in detail-Optomap and Spectralis-noncontact imaging systems that include protocols for performing angiography in infants. Applications of ultra-widefield imaging are illustrated using case studies, including diagnosis, monitoring, and screening.
June 11, 2018: Asia-Pacific Journal of Ophthalmology
Ahmed M Hagag, Alex D Pechauer, Liang Liu, Jie Wang, Miao Zhang, Yali Jia, David Huang
Purpose: Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia. Design: Prospective cohort study. Participants: Nine eyes from 9 healthy participants. Methods: One eye from each participant was scanned using a commercial spectral-domain OCT system. Two repeated macular scans (3 × 3 mm2 ) were acquired at baseline and during oxygen breathing...
April 2018: Ophthalmology Retina
Yinchen Shen, Xun Xu, Hui Cao
BACKGROUND: Pigmented paravenous retinochoroidal atrophy (PPRCA) is an unusual retinal degeneration, and its performance on optical coherence tomography angiography (OCTA) is unclear. We report a Chinese female case of PPRCA and her OCTA features. CASE PRESENTATION: A 66-year-old female patient was referred to the author's center for gradual progressive loss of vision in both eyes and photophobia of 2 years duration. She reported having no family history of inherited ocular diseases...
June 7, 2018: BMC Ophthalmology
Qing Peng, Yutong Chen, Rui Hua
AIM: To establish a novel retinal angiography method, red-free angiography (RFA), to investigate retinal changes in age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). METHODS: Following the venous phase of fundus fluorescein angiography (FFA), the detection mode was switched to red-free reflectance to acquire RFA images using the same parameters. RESULTS: RFA showed subretinal fluid, polyps, and outer retinal tubulation, with a higher definition than the FFA and red-free reflectance results...
June 7, 2018: Ophthalmic Research
Paolo Milani, Giovanni Montesano, Luca Rossetti, Fulvio Bergamini, Alfredo Pece
PURPOSE: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. METHODS: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. RESULTS: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1...
June 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Miaomiao Tang, Xiaoyuan Ji, Hua Xu, Lu Zhang, Airui Jiang, Bin Song, Yuanyuan Su, Yao He
Ocular neovascularization can result in devastating diseases that lead to marked vision impairment and eventual visual loss. In clinical implementation, neovascular eye diseases are firstly diagnosed by fluorescein angiography and then treated by multiple intravitreal injections, which nevertheless involves vision-threatening complications, as well as lack of real-time monitoring disease progression and timely assessment of therapeutic outcomes. To address this critical issue, we herein pre-sent a kind of theranostic agents made of peptide-functionalized silicon nanoparticles (SiNPs), suitable for simultaneous ocular neovascularization imaging and therapy...
June 6, 2018: Analytical Chemistry
Michael J Ammar, Anton M Kolomeyer, Nirali Bhatt, Madhura A Tamhankar, Michael T Mullen, Alexander J Brucker
PURPOSE: We report a patient with branch retinal artery occlusion predominant Susac syndrome and review the literature on current diagnostic modalities and therapeutic approaches for this rare condition. METHODS: Case report. RESULTS: A 23-year-old white male presented with a 5-month history of a scotoma in his right eye vision, headaches, and intermittent paresthesias of the lower extremities. Ophthalmic examination was normal with the exception of a hypopigmented small retinal area inferonasal to the fovea in the right eye...
May 30, 2018: Retinal Cases & Brief Reports
Tingting Gao, Jinfeng Qu, Jing Xiao, Jie Hu, Mingwei Zhao
PURPOSE: To evaluate the efficacy of half-dose photodynamic therapy (PDT) for the treatment of bullous retinal detachment. METHODS: Interventional prospective case series in six eyes from six consecutive patients with bullous retinal detachment. The effected eyes were treated with indocyanine green angiography (ICGA)-guided half-dose PDT with multifocal and large laser spots. Clinical evaluations included best-corrected visual acuity (BCVA), ophthalmoscopy, ophthalmic B scan, fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and ICGA at each scheduled visit at baseline; at 1, 3, and 6 months after PDT; and during follow-up after 6 months...
June 4, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Fangyao Tang, Zihan Sun, Raymond Wong, Jerry Lok, Alexander Lam, Clement C Tham, Carmen Km Chan, Shaheeda Mohamed, Thomas Ch Lam, Simon Kh Szeto, Danny S Ng, Carol Y Cheung
AIM: To examine the correlation of best-corrected visual acuity (BCVA) with intercapillary area (ICA) measured from optical coherence tomography angiography (OCT-A) in patients with diabetes, and to compare the strength of associations between BCVA with ICA and other OCT-A metrics. METHODS: A cross-sectional study involved 447 eyes from 299 patients with diabetes. All participants underwent OCT-A with a swept-source OCT (Triton DRI-OCT, Topcon, Tokyo, Japan). An automated customised MATLAB programme was used to quantify ICA (the mean of the 10 largest areas including foveal avascular zone (FAZ) area (ICA10_FAZ) and excluding FAZ area (ICA10_excFAZ)) and other OCT-A metrics (FAZ area, FAZ circularity and vessel density) from the macular OCT-A images...
June 4, 2018: British Journal of Ophthalmology
Fatih Horozoğlu, Sever Özkan
BACKGROUND: Intravitreal steroid injection is one of the treatment choices in diabetic macular edema (DME). Dexamethasone (Dx) implant is the most novel form of intravitreal steroid therapy. Macular thickness improvement is well known effect of Dx implant however; subfoveal choroidal coat thickness (SFCT) changes need to be investigated. AIMS: To evaluate the early central macular thickness (CMT) and SFCT alterations after single dose dexamethasone implant injection in DME...
June 5, 2018: Balkan Medical Journal
Xiao Na Wang, Qi Sheng You, Hui Ying Zhao, Xiao Yan Peng
OBJECTIVE: To investigate optical coherence tomography (OCT) characteristics of tuberculous serpiginous-like choroiditis (Tb-SLC) and serpiginous choroiditis (SC) and to perform OCT to differentiate between these conditions. METHODS: This retrospective, case-control study examined consecutively enrolled patients with active Tb-SLC or SC. Patients underwent comprehensive ocular examinations and imaging (OCT, color fundus photography, autofluorescence imaging, fluorescein angiography, and indocyanine green angiography)...
May 2018: Biomedical and Environmental Sciences: BES
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