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Retinal angiography

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https://www.readbyqxmd.com/read/29451996/foveal-avascular-zone-area-changes-analyzed-using-oct-angiography-after-successful-rhegmatogenous-retinal-detachment-repair
#1
Je Moon Woo, Yo Sep Yoon, Jong Eun Woo, Jung Kee Min
PURPOSE: To investigate foveal avascular zone (FAZ) area after surgery in patients with rhegmatogenous retinal detachment (RRD) that involved or uninvolved the macula, and to evaluate the correlation between FAZ area and visual outcomes using swept-source optical coherence tomography angiography (OCTA). MATERIALS AND METHODS: This retrospective case-control study included 34 eyes (34 patients) with recent onset RRD that were successfully repaired with a single, uncomplicated surgical procedure (pars plana vitrectomy with gas tamponade)...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29451992/optical-coherence-tomography-angiography-of-the-peripapillary-retina-in-normal-tension-glaucoma-and-chronic-nonarteritic-anterior-ischemic-optic-neuropathy
#2
Rodolfo Mastropasqua, Luca Agnifili, Enrico Borrelli, Vincenzo Fasanella, Lorenza Brescia, Luca Di Antonio, Leonardo Mastropasqua
PURPOSE: To analyze the retinal radial peripapillary capillary (RPC) network in normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) eyes using optical coherence tomography angiography (OCTA). MATERIAL AND METHODS: Twenty-two patients with NTG, 22 patients with unilateral chronic NAION, and 23 age-matched controls were enrolled. Patients underwent OCTA to obtain en face angiograms of the peripapillary region. The main outcome measures were as follows: (1) the whole en face image perfusion density (WPD) and (2) the circumpapillary perfusion density (CPD)...
February 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29450622/comparison-of-retinal-microvascular-changes-in-eyes-with-high-tension-glaucoma-or-normal-tension-glaucoma-a-quantitative-optic-coherence-tomography-angiographic-study
#3
Huan Xu, Ruyi Zhai, Yuan Zong, Xiangmei Kong, Chunhui Jiang, Xinghuai Sun, Yi He, Xiqi Li
PURPOSE: The aim of this study is to determine and compare the changes in the retinal vasculature in eyes with high-tension glaucoma (HTG) or normal-tension glaucoma (NTG). METHODS: The right eyes of 43 HTG subjects, 33 NTG subjects, and 51 age- and sex-matched normal subjects were included in this cross-sectional study. Signals were projected from the internal limiting membrane to retinal pigment epithelium. The retinal perfused vessel densities in the peripapillary and parafoveal regions were measured automatically with optic coherence tomography angiography and the split-spectrum amplitude-decorrelation angiography algorithm...
February 15, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29450547/aflibercept-action-in-a-rabbit-model-of-chronic-retinal-neovascularization-reversible-inhibition-of-pathologic-leakage-with-dose-dependent-duration
#4
Jingtai Cao, Thomas C MacPherson, Bibiana V Iglesias, Yang Liu, Natasha Tirko, George D Yancopoulos, Stanley J Wiegand, Carmelo Romano
Purpose: We establish and characterize the chronic retinal neovascularization (RNV) induced by intravitreal (IVT) injection of DL-α-aminoadipic acid (AAA) in a rabbit model and investigate the extent and duration of inhibitory actions induced by IVT aflibercept on the RNV. Methods: Rabbits received a single IVT injection of AAA, with weekly follow-up fundus photography, fluorescein angiography (FA), and optical coherence tomography (OCT). After 10 weeks, they received a single IVT aflibercept or control injection...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29449066/characteristics-of-headache-in-relation-to-the-manifestation-of-susac-syndrome
#5
Diana Obelienienė, Raminta Macaitytė, Renata Balnytė, Rūta Pėstininkaitė, Rymantė Gleiznienė, Jūratė Balčiūnienė
Susac syndrome is characterized by a clinical triad of encephalopathy, branch retinal artery occlusion, and hearing loss. Due to the absence of the whole complex of the triad in the majority of cases at disease presentation, the syndrome often remains underdiagnosed and untreated. Headache is estimated to affect up to 80% of Susac syndrome patients, but the relevance of headache characteristics and profile is not yet clear. The proposed diagnostic criteria of the European Susac Consortium acknowledge headache as a possible brain manifestation if it is new, described as migrainous or oppressive, and precedes the other symptoms by not more than 6 months...
February 3, 2018: Medicina
https://www.readbyqxmd.com/read/29448042/quantitative-comparisons-between-optical-coherence-tomography-angiography-and-matched-histology-in-the-human-eye
#6
Dong An, Chandrakumar Balaratnasingam, Morgan Heisler, Ashley Francke, MyeongJin Ju, Ian L McAllister, Marinko Sarunic, Dao-Yi Yu
The aim was to quantitatively compare retinal vascular detail as seen on optical coherence tomography angiography (OCTA) and matched histology in the human eye. 13 normal human donor eyes were used. The central retinal artery was cannulated after which human packed red blood cells were perfused through the retinal vasculature. Retinal vessels were imaged using a custom-built OCTA device during red blood cell perfusion. The eye was subsequently perfused with endothelial cell antibodies and the flat-mounted retina studied histologically using a confocal scanning laser microscope...
February 12, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29443808/retinal-microvasculature-alteration-in-paracentral-acute-middle-maculopathy-and-acute-macular-neuroretinopathy-a-quantitative-optical-coherence-tomography-angiography-study
#7
Alexei N Kulikov, Dmitrii S Maltsev, Tatiana A Leongardt
PURPOSE: To present a series of idiopathic paracentral acute middle maculopathy (PAMM) and acute macular neuroretinopathy (AMN) cases and to compare the microvascular retinal status of PAMM/AMN eyes with those of healthy individuals. METHODS: Six eyes with PAMM and two eyes with AMN in a total of six patients were included in this study. Multimodal retinal imaging, including optical coherence tomography angiography, was performed in all patients. The vessel density of the superficial capillary plexus and deep capillary plexus, as well as the area, circularity, and angle of the superficial foveal avascular zone (FAZ) were measured and compared with the same parameters in age-matched healthy individuals...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29443804/progression-of-retinal-ischemia-in-a-case-of-macular-telangiectasia-type-1-after-ranibizumab-injection-optical-coherence-tomography-angiography-findings
#8
Massimo Lorusso, Roberta Zito, Eleni Nikolopoulou, Luisa Micelli Ferrari, Maria Vittoria Cicinelli, Giuseppe Querques, Tommaso Micelli Ferrari
PURPOSE: To describe a case of a 68-year-old man with macular telangiectasia (MacTel) Type 1 in the right eye, showing an increase in capillary ischemia after intravitreal ranibizumab. METHODS: The patient underwent complete ophthalmologic evaluation, including best-corrected visual acuity, intraocular pressure, anterior segment and fundus examination, optical coherence tomography (OCT), and OCT angiography at baseline and on each visit. Fluorescein angiography was performed at baseline...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29443803/newly-diagnosed-asymptomatic-retinal-astrocytic-hamartoma-in-an-older-adult
#9
A Kaan Gündüz, Carol L Shields, Gökçen Çöndü, Ragıp Gürsel
BACKGROUND: To report a coincidentally discovered retinal astrocytic hamartoma in an asymptomatic older woman with no history of tuberous sclerosis or neurofibromatosis. METHODS: A 63-year-old Turkish woman underwent routine ophthalmic examination. RESULTS: Visual acuity was 20/25 in each eye. On fundus examination, the right eye showed a flat yellow-white superficial retinal lesion in the inferotemporal macula and measuring 1 mm in diameter...
February 13, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29443780/analysis-of-the-characteristics-of-optical-coherence-tomography-angiography-for-retinal-cavernous-hemangioma-a-case-report
#10
Shuyuan Lyu, Ming Zhang, Ruikang K Wang, Yunxia Gao, Qinqin Zhang, Xiaoxue Min
RATIONALE: Retinal cavernous hemangioma is a rare congenital vascular malformation with typical fundus changes. Optical coherence tomography angiography (OCTA), which is in rise in the recent years, is a rapid and noninvasive technology to assist in obtaining information regarding the blood flow changes in the fundus lesions from different layers without injecting a contrast agent. PATIENT CONCERNS: A 40-year-old male patient with visual occlusion in the right eye for >1 month was reported...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443367/swept-source-oct-angiography-of-multiple-evanescent-white-dot-syndrome-with-inflammatory-retinal-pigment-epithelial-detachment
#11
Swarup S Swaminathan, Fang Zheng, Andrew R Miller, Giovanni Gregori, Janet L Davis, Philip J Rosenfeld
A 30-year-old woman with photopsias and decreased vision was diagnosed with multiple evanescent white dot syndrome (MEWDS) with an atypical inflammatory subfoveal retinal pigment epithelial detachment (PED) and imaged using swept-source optical coherence tomography (SS-OCT) during several visits. SS-OCT imaging revealed a focal area of attenuated choriocapillaris underneath the PED. An attempt to treat the presumed macular inflammatory lesion with corticosteroids resulted in bilateral exudation consistent with central serous chorioretinopathy...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29443365/detection-of-choriocapillaris-loss-in-alport-syndrome-with-swept-source-oct-angiography
#12
Swarup S Swaminathan, Parth Shah, Fang Zheng, Giovanni Gregori, Philip J Rosenfeld
A patient previously diagnosed with Alport Syndrome was evaluated using multimodal imaging. Optical coherence tomography (OCT) demonstrated significant thinning of the inner retina within the macula, and inner retinal cysts were found in the peripheral macula. OCT angiography demonstrated loss of the choriocapillaris. Abnormal collagen appears to have multiple deleterious effects on the retinal and choroidal structure and vasculature. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:138-141.].
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29443360/swept-source-oct-angiography-of-full-thickness-macular-holes-appearance-and-artifacts
#13
Zofia Michalewska, Jerzy Nawrocki
BACKGROUND AND OBJECTIVE: To evaluate swept-source optical coherence tomography angiography (SS-OCTA) images in full-thickness macular holes (FTMHs). PATIENTS AND METHODS: SS-OCTA of FTMHs was performed before or after surgery. Vitrectomy with the temporal inverted internal limiting membrane flap technique was used. The authors measured the diameter and area of the foveal avascular zone (FAZ) in superficial and deep retina vasculature. RESULTS: In 88 patients, two artifact types were observed...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29443029/in-vivo-multimodal-imaging-and-analysis-of-mouse-laser-induced-choroidal-neovascularization-model
#14
Symantas Ragauskas, Eva Kielczewski, Joseph Vance, Simon Kaja, Giedrius Kalesnykas
Laser-induced choroidal neovascularization (CNV) is a well-established model to mimic the wet form of age-related macular degeneration (AMD). In this protocol, we aim to guide the reader not simply through the technical considerations of generating laser-induced lesions to trigger neovascular processes, but rather focus on the powerful information that can be obtained from multimodal longitudinal in vivo imaging throughout the follow-up period. The laser-induced mouse CNV model was generated by a diode laser administration...
January 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29442245/retrobulbar-and-intraocular-blood-flow-in-anterior-ischaemic-optic-neuropathy-are-linked-to-the-functional-impairment
#15
David Kuerten, Matthias Fuest, Marion Bienert, Niklas Plange
PURPOSE: Evaluation of ocular haemodynamics in patients with acute non-arteritic anterior ischaemic optic neuropathy (NAION) by colour Doppler imaging and fluorescein angiography and correlation of blood flow parameters to visual field loss and visual acuity. METHODS: Blood flow velocities (peak systolic velocity (PSV), end-diastolic velocity (EDV)) of the ophthalmic artery (OA), central retinal artery (CRA) and nasal and temporal posterior ciliary arteries (PCAs) were measured via colour Doppler imaging...
February 13, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29436208/use-of-octa-fa-and-ultra-widefield-imaging-in-quantifying-retinal-ischemia-a-review
#16
Chris Or, Almyr S Sabrosa, Osama Sorour, Malvika Arya, Nadia Waheed
As ischemia remains a key prognostic factor in the management of various diseases including diabetic retinopathy, an increasing amount of research has been dedicated to its quantification as a potential biomarker. Advancements in the quantification of retinal ischemia have been made with the imaging modalities of fluorescein angiography (FA), ultra-widefield imaging (UWF), and optical coherence tomography angiography (OCTA), with each imaging modality offering certain benefits over the others. FA remains the gold standard in assessing the extent of ischemia...
February 13, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29434227/the-nlrp3-inflammasome-may-contribute-to-pathologic-neovascularization-in-the-advanced-stages-of-diabetic-retinopathy
#17
Shyam S Chaurasia, Rayne R Lim, Bhav H Parikh, Yeo Sia Wey, Bo Bo Tun, Tien Yin Wong, Chi D Luu, Rupesh Agrawal, Arkasubhra Ghosh, Alessandra Mortellaro, Elizabeth Rackoczy, Rajiv R Mohan, Veluchamy A Barathi
Diabetic retinopathy (DR) is a retinal microvascular disease characterized by inflammatory and angiogenic pathways. In this study, we evaluated NLRP3 inflammasome in a double transgenic mouse model, Akimba (Ins2 Akita xVEGF +/- ), which demonstrates hyperglycemia, vascular hyperpermeability and neovascularization seen in the proliferative DR. Retinal structural integrity, vascular leakage and function were examined by fundus photography, fluorescein angiography, optical coherence tomography, retinal flat mounts, laser speckle flowgraphy (LSFG), and electroretinography in Akimba and its parental strains, Akita (Ins2 Akita ) and Kimba (trVEGF029) mice...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29429361/-evaluation-of-diabetic-microangiopathy-using-optical-coherence-tomography-angiography
#18
Cecília Czakó, Gábor László Sándor, Mónika Ecsedy, Zsuzsanna Szepessy, Ágnes Borbándy, Miklós Resch, András Papp, Zsuzsa Récsán, Hajnalka Horváth, Zoltán Zsolt Nagy, Illés Kovács
INTRODUCTION: Optical coherence tomography angiography is a non-invasive imaging technique that is able to visualize the different retinal vascular layers using motion contrast to detect blood flow without intravenous dye injection. This method might help to assess microangiopathy in diabetic retinopathy during screening and follow-up. AIM: To quantify retinal microvasculature alterations in both eyes of diabetic patients in relation to systemic risk factors using optical coherence tomography angiography...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29428456/precise-measurement-of-retinal-vascular-bed-area-and-density-on-ultra-wide-fluorescein-angiography-in-normal-subjects
#19
Wenying Fan, Akihito Uji, Enrico Borrelli, Michael Singer, Min Sagong, Jano van Hemert, Srinivas R Sadda
PURPOSE: To characterize and quantify the total retinal vascular bed area (RVBA) and vascular density (VD) in normal eyes using stereographically-corrected ultra-wide (UWF) fluorescein angiography (FA). DESIGN: Cross-sectional study METHODS: Fifty-nine eyes of 31 normal subjects with no evidence of ocular disease underwent FA using the Optos 200Tx. Central and peripheral-steered FA images were montaged and stereographically projected. The early phase FA was used to extract the retinal vasculature as a binary mask...
February 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29423458/posterior-ciliary-artery-occlusion
#20
Sohan Singh Hayreh
Objective: To compare the severity of ischemic damage following posterior ciliary artery (PCA) occlusion in old, atherosclerotic, hypertensive monkeys to that in young monkeys. Design: Experimental study. Subjects: Seven eyes of normal, healthy rhesus monkeys and 8 of old, atherosclerotic, hypertensive monkeys. Methods: By lateral orbitotomy, all PCAs were cut behind the eyeball in both groups of animals. The fundus and the optic disc were evaluated by repeated ophthalmoscopy, color fundus photography and fluorescein fundus angiography, before and immediately after cutting the PCAs and serially thereafter during the follow-up period...
February 2018: Ophthalmology Retina
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