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https://www.readbyqxmd.com/read/27919405/merkel-cell-carcinoma-an-update-of-key-imaging-techniques-prognostic-factors-treatment-and-follow-up
#1
B Llombart, S Kindem, M Chust
Merkel cell carcinoma, though rare, is one of the most aggressive tumors a dermatologist faces. More than a third of patients with this diagnosis die from the disease. Numerous researchers have attempted to identify clinical and pathologic predictors to guide prognosis, but their studies have produced inconsistent results. Because the incidence of Merkel cell carcinoma is low and it appears in patients of advanced age, prospective studies have not been done and no clear treatment algorithm has been developed...
December 2, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27902331/the-plasma-virome-of-febrile-adult-kenyans-shows-frequent-parvovirus-b19-infections-and-a-novel-arbovirus-kadipiro-virus
#2
Carolyne Ngoi, Juliana Siqueira, Linlin Li, Xutao Deng, Peter Mugo, Susan Graham, Matt Price, Eduard Sanders, Eric Delwart
Viral nucleic acids present in the plasma of 498 Kenyan adults with unexplained fever were characterized by metagenomics analysis of 51 sample pools. The highest to lowest fraction of plasma pools was positive for parvovirus B19 (75%), pegivirus C (GBV-C) (67%), alpha anellovirus (59%), gamma anellovirus (55%), beta anellovirus (41%), Dengue virus genotype 2 (DENV-2) (16%), HIV-1 (6%), HHV-6 (6%), HBV (4%), rotavirus (4%), norovirus (4%), rhinovirus C (2%), Merkel cell polyomavirus (MCPyV)(2%) and Kadipiro virus (2%)...
October 24, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27901062/assessing-the-feasibility-of-fly-based-surveillance-of-wildlife-infectious-diseases
#3
Constanze Hoffmann, Melanie Stockhausen, Kevin Merkel, Sébastien Calvignac-Spencer, Fabian H Leendertz
Monitoring wildlife infectious agents requires acquiring samples suitable for analyses, which is often logistically demanding. A possible alternative to invasive or non-invasive sampling of wild-living vertebrates is the use of vertebrate material contained in invertebrates feeding on them, their feces, or their remains. Carrion flies have been shown to contain vertebrate DNA; here we investigate whether they might also be suitable for wildlife pathogen detection. We collected 498 flies in Taï National Park, Côte d'Ivoire, a tropical rainforest and examined them for adenoviruses (family Adenoviridae), whose DNA is frequently shed in feces of local mammals...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895041/infections-and-the-risk-of-incident-giant-cell-arteritis-a-population-based-case-control-study
#4
Rennie L Rhee, Peter C Grayson, Peter A Merkel, Gunnar Tomasson
OBJECTIVES: Alterations in the immune system and infections are suspected to increase susceptibility to giant cell arteritis (GCA). Recently herpes zoster has been directly implicated in the pathogenesis of GCA. We examined the association between prior infections, in particular herpes zoster, and incident GCA in a population-based cohort. METHODS: A nested case-control study was performed using an electronic database from the UK. Cases with newly diagnosed GCA were identified using a validated algorithm and compared with age-matched, sex-matched and practice-matched controls...
November 28, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27891748/an-isosteric-and-fluorescent-dna-base-pair-consisting-of-4-aminophthalimide-and-2-4-diaminopyrimidine-as-c-nucleosides
#5
Marcus Merkel, Lars Dehmel, Nikolaus P Ernsting, Hans-Achim Wagenknecht
A 13mer DNA duplex containing the artificial 4-aminophthalimide:2,4-diaminopyrimidine (4AP:DAP) base pair in the central position was characterized by optical and NMR spectroscopy. The fluorescence of 4AP in the duplex has a large Stokes shift of Δλ=124 nm and a quantum yield of ΦF =24 %. The NMR structure shows that two interstrand hydrogen bonds are formed and confirms the artificial base pairing. In contrast, the 4-N,N-dimethylaminophthalimide moiety prefers the syn conformation in DNA. The fluorescence intensity of this chromophore in DNA is very low and the NMR structure shows no significant interaction with DAP...
November 28, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27891228/a-probabilistic-algorithm-to-process-geolocation-data
#6
Benjamin Merkel, Richard A Phillips, Sébastien Descamps, Nigel G Yoccoz, Børge Moe, Hallvard Strøm
BACKGROUND: The use of light level loggers (geolocators) to understand movements and distributions in terrestrial and marine vertebrates, particularly during the non-breeding period, has increased dramatically in recent years. However, inferring positions from light data is not straightforward, often relies on assumptions that are difficult to test, or includes an element of subjectivity. RESULTS: We present an intuitive framework to compute locations from twilight events collected by geolocators from different manufacturers...
2016: Movement Ecology
https://www.readbyqxmd.com/read/27887864/optimization-of-cgmp-purification-and-expansion-of-umbilical-cord-blood-derived-t-regulatory-cells-in-support-of-first-in-human-clinical-trials
#7
David H McKenna, Darin Sumstad, Diane M Kadidlo, Bjorn Batdorf, Colin J Lord, Sarah C Merkel, Christine M Koellner, Julie M Curtsinger, Carl H June, James L Riley, Bruce L Levine, Jeffrey S Miller, Claudio G Brunstein, John E Wagner, Bruce R Blazar, Keli L Hippen
BACKGROUND AIMS: Thymic-derived regulatory T cells (tTreg) are critical regulators of the immune system. Adoptive tTreg transfer is a curative therapy for murine models of autoimmunity, graft rejection, and graft-versus-host disease (GVHD). We previously completed a "first-in-human" clinical trial using in vitro expanded umbilical cord blood (UCB)-derived tTreg to prevent GVHD in patients undergoing UCB hematopoietic stem cell transplantation (HSCT). tTreg were safe and demonstrated clinical efficacy, but low yield prevented further dose escalation...
November 22, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27880818/merkel-cell-polyomavirus-small-t-antigen-promotes-pro-glycolytic-metabolic-perturbations-required-for-transformation
#8
Christian Berrios, Megha Padi, Mark A Keibler, Donglim Esther Park, Vadim Molla, Jingwei Cheng, Soo Mi Lee, Gregory Stephanopoulos, John Quackenbush, James A DeCaprio
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells. To gain insight into cellular perturbations induced by MCPyV ST, we performed transcriptome analysis of normal human fibroblasts with inducible expression of ST. MCPyV ST dynamically alters the cellular transcriptome with increased levels of glycolytic genes, including the monocarboxylate lactate transporter SLC16A1 (MCT1)...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27879975/metastatic-merkel-cell-carcinoma-response-to-nivolumab
#9
Frances M Walocko, Benjamin Y Scheier, Paul W Harms, Leslie A Fecher, Christopher D Lao
BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy with limited treatment options. Several lines of evidence support the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) axis as a likely contributor to immune evasion in MCC. CASE PRESENTATION: We report a case of a patient with metastatic MCC with a significant and durable response to nivolumab, a humanized IgG4 monoclonal anti-PD-1 antibody. CONCLUSION: Immunotherapy with PD-1/PD-L1 inhibitors has become a rational and promising treatment option for MCC in the advanced or metastatic disease...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27878368/-therapy-options-for-malignant-eyelid-tumors
#10
M Weiling, A Bergua, F E Kruse, L Holbach
Basal cell carcinomas are the most common malignant tumors of the eyelids. Patient history, clinical symptoms and signs, inspection, palpation and slit-lamp examination usually allow a working diagnosis; however, the clinical diagnosis requires histopathological confirmation and determination of the histopathological type. Squamous cell carcinomas, sebaceous gland carcinomas, melanomas and Merkel cell carcinomas can metastasize usually via the lymph vessels into the regional lymph nodes. Microscopically controlled excision of the primary tumor into healthy tissue is most commonly the first goal...
November 22, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27856777/virus-related-merkel-cell-carcinoma-complicating-fingolimod-treatment-for-multiple-sclerosis
#11
Heidi N Beadnall, Anthony J Gill, Sean Riminton, Michael H Barnett
No abstract text is available yet for this article.
November 16, 2016: Neurology
https://www.readbyqxmd.com/read/27856290/enhanced-neurogenic-biomarker-expression-and-reinnervation-in-human-acute-skin-wounds-treated-by-electrical-stimulation
#12
Anil Sebastian, Susan W Volk, Poonam Halai, James Colthurst, Ralf Paus, Ardeshir Bayat
Electrical stimulation (ES) is known to promote cutaneous healing, however its ability to regulate reinnervation remains unclear. Firstly, we show that ES treatment of human acute cutaneous wounds (n=40) increased reinnervation. Next, to define neurophysiological mechanisms through which ES impacts repair, microarray of wound biopsies was performed on days 3, 7, 10 and 14 post-wounding. This identified neural differentiation biomarkers Class III β-tubulin (TUBB3; melanocyte development and neuronal marker) and its upstream molecule Factor Induced Gene 4 (FIG4; phosphatidylinositol (3,5)-bisphosphate 5-phosphatase) as significantly up-regulated post-ES treatment...
November 14, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27852729/functional-role-of-airflow-sensing-hairs-on-the-bat-wing
#13
Susanne J Sterbing-D'Angelo, Mohit Chadha, Kara L Marshall, Cynthia F Moss
The wing membrane of the big brown bat (Eptesicus fuscus) is covered by a sparse grid of microscopic hairs. We showed previously that various tactile receptors (e.g. lanceolate endings and Merkel cell neurite complexes) are associated with wing hair follicles. Furthermore, we found that depilation of these hairs decreased the maneuverability of bats in flight. In the present study, we investigated whether somatosensory signals arising from the hairs carry information about air flow parameters. Neural responses to calibrated air puffs on the wing were recorded from primary somatosensory cortex of Eptesicus fuscus...
November 16, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27851971/distinct-trends-of-dna-methylation-patterning-in-the-innate-and-adaptive-immune-systems
#14
Ronald P Schuyler, Angelika Merkel, Emanuele Raineri, Lucia Altucci, Edo Vellenga, Joost H A Martens, Farzin Pourfarzad, Taco W Kuijpers, Frances Burden, Samantha Farrow, Kate Downes, Willem H Ouwehand, Laura Clarke, Avik Datta, Ernesto Lowy, Paul Flicek, Mattia Frontini, Hendrik G Stunnenberg, José I Martín-Subero, Ivo Gut, Simon Heath
DNA methylation and the localization and post-translational modification of nucleosomes are interdependent factors that contribute to the generation of distinct phenotypes from genetically identical cells. With 112 whole-genome bisulfite sequencing datasets from the BLUEPRINT Epigenome Project, we analyzed the global development of DNA methylation patterns during lineage commitment and maturation of a range of immune system effector cells and the cancers that arise from them. We show clear trends in methylation patterns that are distinct in the innate and adaptive arms of the human immune system, both globally and in relation to consistently positioned nucleosomes...
November 15, 2016: Cell Reports
https://www.readbyqxmd.com/read/27851600/1966-amikacin-pharmacokinetics-during-high-dialysate-flow-on-continuous-venovenous-hemodialysis
#15
Alison Merkel, Cassandra Bellamy, Dan Negoianu, Christina Candeloro
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850229/589-continuous-versus-intermittent-pantoprazole-infusion-therapy-for-gastrointestinal-ulcer-bleeding
#16
Alison Merkel, Douglas Benedetti, Eardie Curry, Fletcher Srygley, Nora Talley, Nicolas Forcade
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27846393/decoding-the-dna-methylome-of-mantle-cell-lymphoma-in-the-light-of-the-entire-b-cell-lineage
#17
Ana C Queirós, Renée Beekman, Roser Vilarrasa-Blasi, Martí Duran-Ferrer, Guillem Clot, Angelika Merkel, Emanuele Raineri, Nuria Russiñol, Giancarlo Castellano, Sílvia Beà, Alba Navarro, Marta Kulis, Núria Verdaguer-Dot, Pedro Jares, Anna Enjuanes, María José Calasanz, Anke Bergmann, Inga Vater, Itziar Salaverría, Harmen J G van de Werken, Wyndham H Wilson, Avik Datta, Paul Flicek, Romina Royo, Joost Martens, Eva Giné, Armando Lopez-Guillermo, Hendrik G Stunnenberg, Wolfram Klapper, Christiane Pott, Simon Heath, Ivo G Gut, Reiner Siebert, Elías Campo, José I Martín-Subero
We analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas (MCL) in comparison with cell subpopulations spanning the entire B cell lineage. We identified two MCL subgroups, respectively carrying epigenetic imprints of germinal-center-inexperienced and germinal-center-experienced B cells, and we found that DNA methylation profiles during lymphomagenesis are largely influenced by the methylation dynamics in normal B cells. An integrative epigenomic approach revealed 10,504 differentially methylated regions in regulatory elements marked by H3K27ac in MCL primary cases, including a distant enhancer showing de novo looping to the MCL oncogene SOX11...
November 14, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27845682/should-violent-offenders-be-forced-to-undergo-neurotechnological-treatment-a-critical-discussion-of-the-freedom-of-thought-objection
#18
Thomas Søbirk Petersen, Kristian Kragh
In this paper we examine one reason for rejecting the view that violent offenders should be forced to undergo neurotechnological treatments (NTs) involving such therapies as psychoactive medication to curb violent behaviour. The reason is based on the concern that forced treatment violates the offender's right to freedom of thought. We argue that this objection can be challenged. First, we present some specifications of what a right to freedom of thought might mean. We focus on the recently published views of Jared Craig, and Jan Cristopher Bublitz and Reinhard Merkel...
November 14, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27832373/human-polyomavirus-and-human-papillomavirus-prevalence-and-viral-load-in-non-malignant-tonsillar-tissue-and-tonsillar-carcinoma
#19
Stephan Herberhold, Martin Hellmich, Marcus Panning, Eva Bartok, Steffi Silling, Baki Akgül, Ulrike Wieland
Human papillomaviruses (HPVs) are an acknowledged cause of a subset of oropharyngeal cancers, especially of tonsillar cancer. Similar to HPV, some human polyomaviruses (HPyVs), such as Merkel cell polyomavirus (MCPyV), have an oncogenic potential. Recently, several novel HPyVs have been discovered. The aim of our study was to determine viral DNA prevalence and viral DNA load of 13 different HPyVs in benign and malignant tonsillar tissue and to compare the data with those found for HPV. A total of 78 biopsies of palatine tonsils with a histologic diagnosis of non-malignant disease (chronic tonsillitis, tonsillar hyperplasia, n = 40) or tonsillar squamous cell carcinoma (n = 38) were included in the study...
November 10, 2016: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/27829143/touch-receptors-undergo-rapid-remodeling-in-healthy-skin
#20
Kara L Marshall, Rachel C Clary, Yoshichika Baba, Rachel L Orlowsky, Gregory J Gerling, Ellen A Lumpkin
Sensory tissues exposed to the environment, such as skin, olfactory epithelia, and taste buds, continuously renew; therefore, peripheral neurons must have mechanisms to maintain appropriate innervation patterns. Although somatosensory neurons regenerate after injury, little is known about how these neurons cope with normal target organ changes. To elucidate neuronal plasticity in healthy skin, we analyzed the structure of Merkel-cell afferents, which are gentle touch receptors, during skin remodeling that accompanies mouse hair-follicle regeneration...
November 8, 2016: Cell Reports
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