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https://www.readbyqxmd.com/read/28802661/efficacy-of-isolated-limb-perfusion-ilp-in-patients-with-merkel-cell-carcinoma-mcc-a-multicenter-experience
#1
L M van Veenendaal, M F Madu, M E T Tesselaar, C Verhoef, D J Grünhagen, A C J van Akkooi
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and potentially aggressive neuroendocrine tumor of the skin, with a propensity for locoregional metastases. In two expert referral centers, isolated limb perfusion (ILP) is used to obtain locoregional control in selected locoregionally advanced MCC patients. This study describes our experience. METHOD: Patients who underwent ILP for MCC were analyzed. ILP was performed with melphalan and tumor necrosis factor (TNF) combination therapy...
August 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28802497/update-on-merkel-cell-carcinoma
#2
REVIEW
Paul W Harms
Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine malignancy. Merkel cell polyomavirus, a tumorigenic DNA virus, is present in most MCC tumors, with implications for tumor biology, diagnosis, and management. Merkel cell polyomavirus-positive tumors have a high burden of UV-signature mutations, similar to melanoma. The histopathologic diagnosis of MCC requires immunohistochemistry to exclude morphologically similar entities. Therapies for advanced disease are currently lacking. Here, the features of MCC are reviewed, including recent molecular discoveries with implications for improved therapy for advanced disease...
September 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28802095/the-diagnostic-utility-of-merkel-cell-polyomavirus-immunohistochemistry-in-a-fine-needle-aspirate-of-metastatic-merkel-cell-carcinoma-of-unknown-primary-to-the-pancreas
#3
Long Li, Kyle Molberg, Naga Cheedella, Joel Thibodeaux, Stacy Hinson, Elena Lucas
Merkel cell carcinoma (MCC) is an aggressive skin tumor with a high tendency for metastases. We report a case of MCC initially presenting as axillary and pancreatic metastases. A 33-year-old HIV-positive Hispanic male presented with a history of a rapidly growing axillary mass. A needle core biopsy demonstrated an epithelioid neoplasm composed of small to medium-sized cells with high nuclear-cytoplasmic ratio, nuclear molding, and frequent mitotic figures. A subsequent PET scan revealed a 1.5 cm FDG avid mass in the pancreas...
August 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28797319/baseline-assessment-of-25-hydroxyvitamin-d-reference-material-and-proficiency-testing-external-quality-assurance-material-commutability-a-vitamin-d-standardization-program-study
#4
Karen Phinney, Christopher Sempos, Susan Tai, Johanna Camara, Stephen Wise, John Eckfeldt, Andrew Hoofnagle, Graham Carter, Julia Jones, Gary Myers, Ramon Durazo-Arvizu, W Greg Miller, Lorin Bachmann, Ian Young, Juanita Pettit, Andrew Liu, Stephen Brooks, Kurtis Sarafin, Michael Thamm, Gert Mensink, Markus Busch, Martina Rabenberg, Kevin Cashman, Mairead Kiely, Karen Galvin, Joy Zhang, Michael Kinsella, Kyungwon Oh, Sun-Wha Lee, Chae Jung, Lorna Cox, Gail Goldberg, Kate Guberg, Sarah Meadows, Ann Prentice, Lu Tian, Patsy Brannon, Robyn Lucas, Peter Crump, Etienne Cavalier, Joyce Merkel, Joseph Betz, Grahame Caldwell
The Vitamin D Standardization Program (VDSP) coordinated a study in 2012 to assess the commutability of reference materials and proficiency testing/external quality assurance materials for total 25-hydroxyvitamin D [25(OH)D] in human serum, the primary indicator of vitamin D status. A set of 50 single-donor serum samples as well as 17 reference and proficiency testing/external quality assessment materials were analyzed by participating laboratories that used either immunoassay or LC-MS methods for total 25(OH)D...
August 10, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28793172/tropomyosin-receptor-kinase-a-expression-on-merkel-cell-carcinoma-cells
#5
Ulrike Wehkamp, Sophie Stern, Sandra Krüger, Axel Hauschild, Christoph Röcken, Friederike Egberts
Importance: Merkel cell carcinoma (MCC) is a malignant neuroendocrine skin tumor frequently associated with the Merkel cell polyomavirus. Immune checkpoint therapy showed remarkable results, although not all patients are responsive to this therapy. Anti-tropomyosin receptor kinase A (TrkA)-targeted treatment has shown promising results in several tumor entities. Objective: To determine TrkA expression in MCC as a rationale for potential targeted therapy. Design, Setting, and Participants: This case series study investigated the MCC specimens of 55 patients treated at the Department of Dermatology, University Hospital of Schleswig-Holstein, Kiel, Germany, from January 1, 2005, through December 31, 2015...
August 9, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28770842/persistent-anthrax-as-a-major-driver-of-wildlife-mortality-in-a-tropical-rainforest
#6
Constanze Hoffmann, Fee Zimmermann, Roman Biek, Hjalmar Kuehl, Kathrin Nowak, Roger Mundry, Anthony Agbor, Samuel Angedakin, Mimi Arandjelovic, Anja Blankenburg, Gregory Brazolla, Katherine Corogenes, Emmanuel Couacy-Hymann, Tobias Deschner, Paula Dieguez, Karsten Dierks, Ariane Düx, Susann Dupke, Henk Eshuis, Pierre Formenty, Yisa Ginath Yuh, Annemarie Goedmakers, Jan F Gogarten, Anne-Céline Granjon, Scott McGraw, Roland Grunow, John Hart, Sorrel Jones, Jessica Junker, John Kiang, Kevin Langergraber, Juan Lapuente, Kevin Lee, Siv Aina Leendertz, Floraine Léguillon, Vera Leinert, Therese Löhrich, Sergio Marrocoli, Kerstin Mätz-Rensing, Amelia Meier, Kevin Merkel, Sonja Metzger, Mizuki Murai, Svenja Niedorf, Hélène De Nys, Andreas Sachse, Joost van Schijndel, Ulla Thiesen, Els Ton, Doris Wu, Lothar H Wieler, Christophe Boesch, Silke R Klee, Roman M Wittig, Sébastien Calvignac-Spencer, Fabian H Leendertz
Anthrax is a globally important animal disease and zoonosis. Despite this, our current knowledge of anthrax ecology is largely limited to arid ecosystems, where outbreaks are most commonly reported. Here we show that the dynamics of an anthrax-causing agent, Bacillus cereus biovar anthracis, in a tropical rainforest have severe consequences for local wildlife communities. Using data and samples collected over three decades, we show that rainforest anthrax is a persistent and widespread cause of death for a broad range of mammalian hosts...
August 2, 2017: Nature
https://www.readbyqxmd.com/read/28765251/severe-infection-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#7
Aladdin J Mohammad, Mårten Segelmark, Rona Smith, Martin Englund, Jan-Åke Nilsson, Kerstin Westman, Peter A Merkel, David R W Jayne
OBJECTIVE: To compare the rate of severe infections after the onset of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with the rate in the background population, and to identify predictors of severe infections among patients with AAV. METHODS: The study cohort was 186 patients with AAV diagnosed from 1998 to 2010, consisting of all known cases in a defined population in southern Sweden. For each patient, 4 age- and sex-matched reference subjects were randomly chosen from the background population...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28765246/the-omeract-core-domain-set-for-outcome-measures-for-clinical-trials-in-polymyalgia-rheumatica
#8
Sarah L Mackie, Helen Twohig, Lorna M Neill, Eileen Harrison, Beverley Shea, Rachel J Black, Tanaz A Kermani, Peter A Merkel, Christian D Mallen, Frank Buttgereit, Chetan Mukhtyar, Lee S Simon, Catherine L Hill
OBJECTIVE: To inform development of a core domain set for outcome measures for clinical trials in polymyalgia rheumatica (PMR), we conducted patient consultations, a systematic review, a Delphi study, and 2 qualitative studies. METHODS: Domains identified by 70% or more of physicians and/or patients in the Delphi study were selected. The conceptual framework derived from the 2 qualitative research studies helped inform the meaning of each domain and its relationship to the others...
August 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28763797/evaluation-of-real-world-treatment-outcomes-in-patients-with-distant-metastatic-merkel-cell-carcinoma-following-second-line-chemotherapy-in-europe
#9
Jürgen C Becker, Eva Lorenz, Selma Ugurel, Thomas K Eigentler, Felix Kiecker, Claudia Pföhler, Ivonne Kellner, Friedegund Meier, Katharina Kähler, Peter Mohr, Carola Berking, Gabriele Haas, Christoph Helwig, Dina Oksen, Dirk Schadendorf, Lisa Mahnke, Murtuza Bharmal
BACKGROUND AND AIMS: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer; few treatments exist for patients with advanced disease. Once tumors metastasize to distant sites, patients generally receive chemotherapy, but response duration and progression-free survival (PFS) are typically short. Few studies have assessed the efficacy of second-line chemotherapy for metastatic MCC. Here, we studied outcomes in patients who received ≥ 2 lines of chemotherapy for metastatic MCC. MATERIALS AND METHODS: Patients in an MCC-specific registry diagnosed with stage IV MCC between November 1, 2004, and September 15, 2015, and treated with second-line or later chemotherapy were analyzed retrospectively...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28763479/expression-of-merkelcell-polyomavirus-mcpyv-large-t-antigen-in-merkel-cell-carcinoma-lymph-node-metastases-predicts-poor-outcome
#10
Georg Haymerle, Stefan Janik, Alexandra Fochtmann, Johannes Pammer, Helga Schachner, Lucas Nemec, Michael Mildner, Roland Houben, Matthaeus Ch Grasl, Boban M Erovic
BACKGROUND: The aim of this study was to determine the prevalence of MCPyV in Merkel cell carcinoma (MCC) primaries versus lymph node metastasis and to evaluate possible prognostic factors. METHODS: Samples of MCC primaries and lymph node metastases were stained immunohistochemically for the MCPyV large T-antigen and expression was compared to patients´ clinical outcome. RESULTS: 41 MCC patients were included. 33 (61%) out of 54 specimens were MCPyV-positive in the immunohistochemistry...
2017: PloS One
https://www.readbyqxmd.com/read/28762116/merkel-cell-carcinoma-of-the-head-and-neck-recommendations-for-diagnostics-and-treatment
#11
REVIEW
Urs Dietmar Achim Müller-Richter, Anja Gesierich, Alexander Christian Kübler, Stefan Hartmann, Roman Camillus Brands
BACKGROUND: Merkel cell carcinoma (MCC) is a rare, aggressive tumor that often occurs in the head and neck region. Because of these features, the classifications and diagnostic and treatment regimens are frequently modified. Especially in the anatomically complex head and neck region, it is crucial to be aware of the current recommendations for diagnostics and treatment of MCC to ensure appropriate treatment. This overview aims to summarize the currently available literature. METHODS: The authors reviewed the relevant literature and international guidelines for MCC from 2012 to 2017 with respect to epidemiology and prognosis, diagnostic procedures and imaging, surgery, radiation, systemic treatment, and aftercare...
July 31, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28761962/coincident-metastatic-melanoma-and-merkel-cell-carcinoma-with-complete-remission-on-treatment-with-pembrolizumab
#12
Alexander Thiem, Hermann Kneitz, Patrick Schummer, Stefan Herz, David Schrama, Roland Houben, Matthias Goebeler, Bastian Schilling, Anja Gesierich
No abstract text is available yet for this article.
August 1, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28756078/patient-reported-outcomes-in-takayasu-s-arteritis
#13
Fatma Alibaz-Oner, Antoine G Sreih, Peter A Merkel, Haner Direskeneli
Patient-reported outcomes (PROs) are assessment tools coming directly from patients about their feelings, perceptions, health-related functions, and treatment effects without interpretation by health-care providers. There is a global interest for more "patient-centered care" and PROs in rheumatology. Assessment of disease impact through patient-reported outcome (PRO) measures is a key element for clinical care and clinical research in Takayasu's arteritis (TAK). Currently there are no disease-specific PRO measures to assess quality of life for patients with TAK...
July 26, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28753430/defining-a-cancer-dependency-map
#14
Aviad Tsherniak, Francisca Vazquez, Phil G Montgomery, Barbara A Weir, Gregory Kryukov, Glenn S Cowley, Stanley Gill, William F Harrington, Sasha Pantel, John M Krill-Burger, Robin M Meyers, Levi Ali, Amy Goodale, Yenarae Lee, Guozhi Jiang, Jessica Hsiao, William F J Gerath, Sara Howell, Erin Merkel, Mahmoud Ghandi, Levi A Garraway, David E Root, Todd R Golub, Jesse S Boehm, William C Hahn
Most human epithelial tumors harbor numerous alterations, making it difficult to predict which genes are required for tumor survival. To systematically identify cancer dependencies, we analyzed 501 genome-scale loss-of-function screens performed in diverse human cancer cell lines. We developed DEMETER, an analytical framework that segregates on- from off-target effects of RNAi. 769 genes were differentially required in subsets of these cell lines at a threshold of six SDs from the mean. We found predictive models for 426 dependencies (55%) by nonlinear regression modeling considering 66,646 molecular features...
July 27, 2017: Cell
https://www.readbyqxmd.com/read/28753336/beam-recoil-polarization-measurement-of-%C3%AF-0-electroproduction-on-the-proton-in-the-region-of-the-roper-resonance
#15
S Štajner, P Achenbach, T Beranek, J Beričič, J C Bernauer, D Bosnar, R Böhm, L Correa, A Denig, M O Distler, A Esser, H Fonvieille, J M Friedrich, I Friščić, S Kegel, Y Kohl, H Merkel, M Mihovilovič, J Müller, U Müller, L Nungesser, J Pochodzalla, B S Schlimme, M Schoth, F Schulz, C Sfienti, S Širca, M Thiel, L Tiator, A Tyukin, A Weber, I Yaron
The helicity-dependent recoil proton polarizations P_{x}^{'} and P_{z}^{'} as well as the helicity-independent component P_{y} have been measured in the p(e[over →],e^{'}p[over →])π^{0} reaction at four-momentum transfer Q^{2}≃0.1  GeV^{2}, center-of-mass proton emission angle θ_{p}^{*}≃90°, and invariant mass W≃1440  MeV. This first precise measurement of double-polarization observables in the energy domain of the Roper resonance P_{11}(1440) by exploiting recoil polarimetry has allowed for the extraction of its scalar electroexcitation amplitude at an unprecedentedly low value of Q^{2}, establishing a powerful instrument for probing the interplay of quark and meson degrees of freedom in the nucleon...
July 14, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28746702/identifying-an-optimal-adjuvant-radiotherapy-dose-for-extremity-and-trunk-merkel-cell-carcinoma-following-resection-an-analysis-of-the-national-cancer-database
#16
Sagar A Patel, Muhammad M Qureshi, Debjani Sahni, Minh Tam Truong
Importance: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine neoplasm with a high risk of recurrence following resection. Despite a rising incidence over the past 3 decades, there is a paucity of prospective data owing to the rarity of this disease. Objective: To determine the optimal adjuvant radiation therapy (RT) dose following resection of localized MCC of the extremities or trunk. Design, Setting, and Participants: Using the National Cancer Database, a large national database consisting of a heterogeneous population and treatment settings, we retrospectively analyzed a cohort of 2093 patients 18 years or older with stage I to III MCC of the extremities and/or trunk treated with definitive surgery and adjuvant RT between 1998 and 2011...
July 26, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28740896/the-big-data-effort-in-radiation-oncology-data-mining-or-data-farming
#17
REVIEW
Charles S Mayo, Marc L Kessler, Avraham Eisbruch, Grant Weyburne, Mary Feng, James A Hayman, Shruti Jolly, Issam El Naqa, Jean M Moran, Martha M Matuszak, Carlos J Anderson, Lynn P Holevinski, Daniel L McShan, Sue M Merkel, Sherry L Machnak, Theodore S Lawrence, Randall K Ten Haken
Although large volumes of information are entered into our electronic health care records, radiation oncology information systems and treatment planning systems on a daily basis, the goal of extracting and using this big data has been slow to emerge. Development of strategies to meet this goal is aided by examining issues with a data farming instead of a data mining conceptualization. Using this model, a vision of key data elements, clinical process changes, technology issues and solutions, and role for professional societies is presented...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740894/postoperative-radiation-therapy-is-associated-with-a-reduced-risk-of-local-recurrence-among-low-risk-merkel-cell-carcinomas-of-the-head-and-neck
#18
Seesha R Takagishi, Tessa E Marx, Christopher Lewis, Erica S Tarabadkar, Ilsa D Juhlin, Astrid Blom, Jayasri G Iyer, Jay J Liao, Yolanda D Tseng, Teresa Fu, Paul Nghiem, Upendra Parvathaneni
PURPOSE: Merkel cell carcinoma (MCC) is a rare and often aggressive skin cancer. Typically, surgery is the primary treatment. Postoperative radiation therapy (PORT) is often recommended to improve local control. It is unclear whether PORT is indicated in patients with favorable Stage IA head and neck (HN) MCC. METHODS AND MATERIALS: We conducted a retrospective analysis of 46 low-risk HN MCC cases treated between 2006 and 2015. Inclusion criteria were defined as a primary tumor size of ≤ 2 cm, negative pathological margins, negative sentinel lymph node biopsy, and no immunosuppression...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28739498/increased-expression-of-ezh2-in-merkel-cell-carcinoma-is-associated-with-disease-progression-and-poorer-prognosis
#19
Kelly L Harms, Heather Chubb, Lili Zhao, Douglas R Fullen, Christopher K Bichakjian, Timothy M Johnson, Shannon Carskadon, Nallasivam Palanisamy, Paul W Harms
Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that affects tumorigenesis by epigenetic gene silencing. Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma that has a high risk of disease progression with nodal and distant metastases. Here, we evaluated EZH2 expression by immunohistochemistry in a cohort of 85 MCC tumors (29 primary tumors, 41 lymph node metastases, 13 in-transit metastases, and 2 distant metastases) with clinical follow-up. We show strong/moderate EZH2 expression in 54% of tumors...
July 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28735439/surgical-management-of-periocular-cancers-high-and-low-risk-features-drive-treatment
#20
REVIEW
Richard C Allen
PURPOSE OF REVIEW: Recent advances in the treatment of eyelid tumors have centered on the excision, evaluation of margins, role of sentinel lymph node biopsy, and adjunctive/adjuvant systemic and radiation therapy. The purpose of this review is to elaborate on these advances. RECENT FINDINGS: Mohs excision of basal cell carcinoma and squamous cell carcinoma continues to provide the greatest success in complete excision of the cancer, especially in those cases of high-risk disease including medial canthal location and recurrent disease...
September 2017: Current Oncology Reports
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