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https://www.readbyqxmd.com/read/29150766/spinobot-an-mri-guided-needle-positioning-system-for-spinal-cellular-therapeutics
#1
Alexander Squires, John N Oshinski, Nicholas M Boulis, Zion Tsz Ho Tse
The neurodegenerative disease amyotrophic lateral sclerosis (ALS) results in the death of motor neurons in voluntary muscles. There are no cures for ALS and few available treatments. In studies with small animal models, injection of cellular therapeutics into the anterior horn of the spinal cord has been shown to inhibit the progression of ALS. It was hypothesized that spinal injection could be made faster and less invasive with the aid of a robot. The robotic system presented-SpinoBot-uses MRI guidance to position a needle for percutaneous injection into the spinal cord...
November 17, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29136287/quantification-of-mri-visibility-and-artefacts-at-3t-of-liquid-fiducial-marker-in-a-pancreas-tissue-mimicking-phantom
#2
Sergej Schneider, Rasmus Irming Jølck, Esther Gera Cornelia Troost, Aswin Louis Hoffmann
PURPOSE: X-ray based position verification of the target volume in image-guided radiation therapy (IGRT) of patients with pancreatic ductal adenocarcinoma (PDAC) is currently performed on solid fiducial markers that are implanted under endoscopic ultrasonography. A new biodegradable liquid fiducial marker has recently been introduced. To assess its potential use for magnetic resonance imaging (MRI) guided photon or proton radiotherapy of PDAC, the MRI visibility and artefacts of this marker were quantified and compared against solid gold markers...
November 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29135471/first-patients-treated-with-a-1-5-t-mri-linac-clinical-proof-of-concept-of-a-high-precision-high-field-mri-guided-radiotherapy-treatment
#3
B W Raaymakers, I M Jürgenliemk-Schulz, G H Bol, M Glitzner, A N T J Kotte, B van Asselen, J C J de Boer, J J Bluemink, S L Hackett, M A Moerland, S J Woodings, J W H Wolthaus, H M van Zijp, M E P Philippens, R Tijssen, J G M Kok, E N de Groot-van Breugel, I Kiekebosch, L T C Meijers, C N Nomden, G G Sikkes, P A H Doornaert, W S C Eppinga, N Kasperts, L G W Kerkmeijer, J H A Tersteeg, K J Brown, B Pais, P Woodhead, J J W Lagendijk
The integration of 1.5 T MRI functionality with a radiotherapy linear accelerator (linac) has been pursued since 1999 by the UMC Utrecht in close collaboration with Elekta and Philips. The idea behind this integrated device is to offer unrivalled, online and real-time, soft-tissue visualization of the tumour and the surroundings for more precise radiation delivery. The proof of concept of this device was given in 2009 by demonstrating simultaneous irradiation and MR imaging on phantoms, since then the device has been further developed and commercialized by Elekta...
November 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29128843/shape-controlled-magnetic-mesoporous-silica-nanoparticles-for-magnetically-mediated-suicide-gene-therapy-of-hepatocellular-carcinoma
#4
Zheng Wang, Zhimin Chang, Mengmeng Lu, Dan Shao, Juan Yue, Dian Yang, Xiao Zheng, Mingqiang Li, Kan He, Ming Zhang, Li Chen, Wen-Fei Dong
Magnetic nanoparticles (NPs) have emerged as a promising tool for suicide gene therapy. However, the separate delivery of the suicide gene and prodrug in current systems limits their clinical translation. Therefore, improving magnetically mediated suicide gene therapy by exploring higher performance magnetic NP-based hybrid nanoplatforms is an important challenge. In the current study, shape-controlled magnetic mesoporous silica nanoparticles (M-MSNs) were prepared, and their performance in magnetic resonance imaging (MRI)-guided, magnetically targeted and hyperthermia-enhanced suicide gene therapy of hepatocellular carcinoma (HCC) was investigated...
November 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/29117337/seeg-is-a-safe-procedure-for-a-comprehensive-anatomic-exploration-of-the-insula-a-retrospective-study-of-108-procedures-representing-254-transopercular-insular-electrodes
#5
Anne Laure Salado, Laurent Koessler, Gabriel De Mijolla, Emmanuelle Schmitt, Jean-Pierre Vignal, Thierry Civit, Louise Tyvaert, Jacques Jonas, Louis Georges Maillard, Sophie Colnat- Coulbois
BACKGROUND: The exploration of the insula in pre-surgical evaluation of epilepsy is considered to be associated with a high vascular risk resulting in an incomplete exploration of the insular cortex. OBJECTIVE: To report a retrospective observational study of insular exploration using stereoelectroencephalography (sEEG) with transopercular and parasagittal oblique intracerebral electrodes from January 2008 to January 2016. The first purpose of this study was to evaluate the surgical risks of insular cortex sEEG exploration...
May 9, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29116748/mno2-functionalized-co-p-nanocomposite-a-new-theranostic-agent-for-ph-triggered-t1-t2-dual-modality-magnetic-resonance-imaging-guided-chemo-photothermal-synergistic-therapy
#6
Longhai Jin, Jianhua Liu, Ying Tang, Lanqing Cao, Tianqi Zhang, Qinghai Yuan, Yinghui Wang, Hongjie Zhang
Construction of stimuli-responsive theranostic nanoagents that can improve the sensitivity of diagnostic imaging and boost the therapeutic efficiency has been demostrated to a promising approach for cancer diagnosis and treatment. Herein, we constructed a novel theranostic agent with Co-P nanocomposites as core, mesoporous silica as shell, and MnO2 nanosheets as "gatekeeper", which have been employed for pH-activatable T1/T2 dual mode MRI-guided chemo-photothermal combination anticancer therapy in vitro and in vivo...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29105881/mri-guided-preoperative-125-i-seed-localizations-case-report
#7
Christine Lee
Preoperative nonwire localizations with (125) I seeds are performed using mammographic or ultrasonographic guidance. Current MRI-guided interventions in the breast are primarily limited to biopsies and wire localizations. Occasionally, nonwire localization with (125) I seeds is preferred, but the target is only well seen on MRI. This case report describes how MRI-guided preoperative two (125) I seed bracket localization was performed.
November 5, 2017: Breast Journal
https://www.readbyqxmd.com/read/29104835/online-adaptive-radiation-therapy-implementation-of-a-new-process-of-care
#8
James Lamb, Minsong Cao, Amar Kishan, Nzhde Agazaryan, David H Thomas, Narek Shaverdian, Yingli Yang, Suzette Ray, Daniel A Low, Ann Raldow, Michael L Steinberg, Percy Lee
Onboard magnetic resonance imaging (MRI) guided radiotherapy is now clinically available in nine centers in the world. This technology has facilitated the clinical implementation of online adaptive radiotherapy (OART), or the ability to alter the daily treatment plan based on tumor and anatomical changes in real-time while the patient is on the treatment table. However, due to the time sensitive nature of OART, implementation in a large and busy clinic has many potential obstacles as well as patient-related safety considerations...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29103479/is-breast-magnetic-resonance-imaging-mri-useful-for-diagnosis-of-additional-sites-of-disease-in-patients-recently-diagnosed-with-pure-ductal-carcinoma-in-situ-dcis
#9
A P Benveniste, T Ortiz-Perez, L O Ebuoma, K A Sepulveda, F J Severs, A Roark, T Wang, E L Sedgwick
PURPOSE: To determine if breast MRI is useful for detecting additional or invasive sites of disease in patients initially diagnosed with pure DCIS. MATERIALS AND METHODS: A retrospective review of women diagnosed with pure DCIS who underwent a breast MRI for evaluation of extent of disease was performed at a single institution from January 2013 to April 2015. Data analysis included imaging (mammography, ultrasound and MRI) and pathology characteristics (histology and biomarker status) of the primary DCIS as well as descriptors for the additional sites of disease incidentally found by breast MRI...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29102740/clinical-outcomes-with-mri-guided-image-based-brachytherapy-in-cervical-cancer-an-institutional-experience
#10
Vijai Simha, Bhavana Rai, Firuza D Patel, Rakesh Kapoor, Suresh C Sharma, Oinam A Singh, Veenu Singla, Bhaswanth Dhanireddy, Sushmita Ghoshal
PURPOSE: To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer. METHODS AND MATERIALS: Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guided BT 7 Gy × 4 fractions with a minimum dose of 85.7 Gy (EQD2) to the high-risk clinical target volume (HRCTV). The BT dose was initially prescribed to point A and plans were optimized to ensure coverage of both point A and HRCTV while maintaining doses to the organs at risk within the recommended constraints...
November 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29101365/biomineral-nano-theranostic-agent-for-magnetic-resonance-image-guided-augmented-radiofrequency-ablation-of-liver-tumor
#11
Anusha Ashokan, Vijay Harish Somasundaram, Genekehal Siddaramana Gowd, Ida M Anna, Giridharan L Malarvizhi, Badrinathan Sridharan, Rupal B Jobanputra, Reshmi Peethambaran, A K K Unni, Shantikumar Nair, Manzoor Koyakutty
Theranostic nanoparticles based on biocompatible mineral compositions can significantly improve the translational potential of image guided cancer nano-therapy. Here, we report development of a single-phase calcium phosphate biomineral nanoparticle (nCP) with dual-mode magnetic resonance contrast (T1-T2) together with radiofrequency (RF) mediated thermal response suitable for image-guided RF ablation of cancer. The nanoparticles (NP) are engineered to provide dual MR contrast by an optimized doping concentration (4...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29097137/3t-multiparametric-mri-guided-high-dose-rate-combined-intracavitary-and-interstitial-adaptive-brachytherapy-for-the-treatment-of-cervical-cancer-with-a-novel-split-ring-applicator
#12
Elisha Fredman, Bryan Traughber, Tarun Podder, Valdir Colussi, Yiran Zheng, Suzanne Russo, Karin Herrmann, Raj Paspulati, Steven Waggoner, Kristin Zanotti, Christa Nagel, John Nakayama, Mitchell Machtay, Rodney Ellis
PURPOSE: To evaluate the role of 3T-MRI-guided adaptive high-dose-rate (HDR) combined intracavitary and interstitial brachytherapy for cervical cancer using a novel intracavitary split-ring (ICSR) applicator adapter. METHODS AND MATERIALS: We retrospectively reviewed all HDR brachytherapy cases from 2013 to 2015 using an ICSR applicator. Initial optimization was performed using 3T multiparametric MRI (mpMRI) series with an applicator in place. The mpMRI series were discretionarily acquired before subsequent fractions for possible target adaptation...
October 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29096215/intermittent-theta-burst-stimulation-induces-correlated-changes-in-cortical-and-corticospinal-excitability-in-healthy-older-subjects
#13
Tamara Gedankien, Peter J Fried, Alvaro Pascual-Leone, Mouhsin M Shafi
OBJECTIVE: We studied the correlation between motor evoked potentials (MEPs) and early TMS-evoked EEG potentials (TEPs) from single-pulse TMS before and after intermittent Theta Burst Stimulation (iTBS) to the left primary motor cortex (M1) in 17 healthy older participants. METHODS: TMS was targeted to the hand region of M1 using a MRI-guided navigated brain stimulation system and a figure-of-eight biphasic coil. MEPs were recorded from the right first dorsal interosseous muscle using surface EMG...
September 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29094851/prospective-nonrandomized-study-of-diagnostic-accuracy-comparing-prostate-cancer-detection-by-transrectal-ultrasound-guided-biopsy-to-magnetic-resonance-imaging-with-subsequent-mri-guided-biopsy-in-biopsy-na%C3%A3-ve-patients
#14
Roberto Castellucci, Ana I Linares Quevedo, Francisco J Sánchez Gómez, Jesús Díez Rodríguez, Leopoldo Cogorno, Isidro Cogollos Acuña, Isabel Salmerón Béliz, Marta Muñoz Fernández de Legaría, Luis Martínez Piñeiro
BACKGROUND: To evaluate the diagnostic efficacy in cancer prostate (PCa) of Multiparametric prostate magnetic resonance imaging (mp-MRI) targeted biopsy compared to standard systematic transrectal ultrasound-guided biopsy (TRUSGB) in biopsy-naïve patients. METHODS: A total of 168 biopsy-naïve men with clinical suspicion of PCa due to elevated PSA levels and/or an abnormal digital rectal examination were consecutively enrolled from July 2011 to July 2014. All patients underwent TRUSGB...
December 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29076274/transcranial-mri-guided-high-intensity-focused-ultrasound-for-treatment-of-essential-tremor-a-pilot-study-on-the-correlation-between-lesion-size-lesion-location-thermal-dose-and-clinical-outcome
#15
Christian Federau, Maged Goubran, Jarrett Rosenberg, Jaimie Henderson, Casey H Halpern, Veronica Santini, Max Wintermark, Kim Butts Pauly, Pejman Ghanouni
BACKGROUND: Transcranial MR-guided high-intensity focused ultrasound (tcMRgFUS) is a promising noninvasive method to treat medication-refractory essential tremor. PURPOSE/HYPOTHESIS: To define the correlation between lesion size after ablation, thermal dose, and clinical outcome in tcMRgFUS treatment of essential tremor. STUDY TYPE: Retrospective. POPULATION/SUBJECTS/PHANTOM/SPECIMEN/ANIMAL MODEL: Eight patients with medication-refractory essential tremor were treated using a tcMRgFUS system at 3T...
October 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29066883/mri-guided-targeting-delivery-of-doxorubicin-with-reduction-responsive-lipid-polymer-hybrid-nanoparticles
#16
Bo Wu, Shu-Ting Lu, Kai Deng, Hui Yu, Can Cui, Yang Zhang, Ming Wu, Ren-Xi Zhuo, Hai-Bo Xu, Shi-Wen Huang
In recent years, there has been increasing interest in developing a multifunctional nanoscale platform for cancer monitoring and chemotherapy. However, there is still a big challenge for current clinic contrast agents to improve their poor tumor selectivity and response. Herein, we report a new kind of Gd complex and folate-coated redox-sensitive lipid-polymer hybrid nanoparticle (Gd-FLPNP) for tumor-targeted magnetic resonance imaging and therapy. Gd-FLPNPs can simultaneously accomplish diagnostic imaging, and specific targeting and controlled release of doxorubicin (DOX)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29064370/stability-analysis-of-a-deterministic-dose-calculation-for-mri-guided-radiotherapy
#17
Oleksandr Zelyak, B Gino Fallone, Joel St Aubin
Modern effort in radiotherapy to address the challenges of tumor localization and motion has led to the development of MRI guided radiotherapy technologies. Accurate dose calculations must properly account for the effects of the MRI magnetic fields. Previous work has investigated the accuracy of a deterministic linear Boltzmann transport equation (LBTE) solver that includes magnetic field, but not the stability of the iterative solution method. In this work, we perform a stability analysis of this deterministic algorithm including an investigation of the convergence rate dependencies on the magnetic field, material density, energy, and anisotropy expansion...
October 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29060836/a-new-4-dof-parallel-robot-for-mri-guided-percutaneous-interventions-kinematic-analysis
#18
Jin Seob Kim, David Levi, Reza Monfaredi, Kevin Cleary, Iulian Iordachita
In this paper, we present the concept of a novel 4-DOF parallel robot for MRI-guided percutaneous interventions. This system belongs to the class of patient-mounted robots, with two parallel circular stages along which two actuating joints move. As a first step, we present the concept of the robot and its kinematic analysis. This robot has the potential of increased rigidity and reduced inertial effect compared to its predecessor. It also minimizes the number of moving components, which enhances safety during the robot's operation...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057436/non-invasive-therapeutic-use-of-high-intensity-focused-ultrasound-hifu-with-3-tesla-magnetic-resonance-imaging-in-women-with-symptomatic-uterine-fibroids
#19
Tomasz Łoziński, Justyna Filipowska, Grzegorz Gurynowicz, Iwona Gabriel, Artur Czekierdowski
Benign uterine fibroids are common female genital tract tumors and if symptomatic often require extensive surgery. When tumors are multiple and large or unusually located, the operative treatment may lead to significant morbidity and compromise quality of life. Recovery period after surgical treatment may be complicated by patient's medical condition and wound healing problems. Currently used other non-surgical treatment modalities usually provide only a temporal symptoms relief and may not be efficient in all affected women...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29054380/toxicity-and-efficacy-of-re-irradiation-of-high-grade-glioma-in-a-phase-i-dose-and-volume-escalation-trial
#20
Søren Møller, Per Munck Af Rosenschöld, Junia Costa, Ian Law, Hans Skovgaard Poulsen, Svend Aage Engelholm, Silke Engelholm
INTRODUCTION: The purpose of this study was to evaluate the safety and efficacy of PET and MRI guided re-irradiation of recurrent high-grade glioma (HGG) and to assess the impact of radiotherapy dose, fractionation and irradiated volume. MATERIAL AND METHODS: Patients with localized, recurrent HGG (grades III-IV) and no other treatment options were eligible for a prospective phase I trial. Gross tumor volumes for radiotherapy were defined using T1-contrast enhanced MRI and (18)F-fluoro-ethyl tyrosine PET...
October 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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