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https://www.readbyqxmd.com/read/29786775/stormram-4-an-mr-safe-robotic-system-for-breast-biopsy
#1
Vincent Groenhuis, Françoise J Siepel, Jeroen Veltman, Jordy K van Zandwijk, Stefano Stramigioli
Suspicious lesions in the breast that are only visible on magnetic resonance imaging (MRI) need to be biopsied under MR guidance with high accuracy and efficiency for accurate diagnosis. The aim of this study is to present a novel robotic system, the Stormram 4, and to perform preclinical tests in an MRI environment. Excluding racks and needle, its dimensions are 72 × 51 × 40 mm. The Stormram 4 is driven by two linear and two curved pneumatic stepper motors. The linear motor is capable of exerting 63 N of force at a pressure of 0...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786588/-infectious-complications-of-prostate-biopsy
#2
Marcin Łykowski, Bartosz Dybowski, Sławomir Poletajew, Tomasz Piecha, Piotr Radziszewski
Prostate cancer is the second most common malignancy in men in Poland. Prostate biopsy remains the gold standard for diagnosis. Every year, the number of procedures is increasing, so knowledge of possible complications is becoming crucial. Over time, a continuous increase in infectious complications of prostate biopsy is observed, so it is important to identify risk factors and preventive methods. Antibiotic prophylaxis is mandatory for prostate biopsy. Simultaneously, complications after prostate biopsy affect as many as 90% of patients, including up to 17% of infective complications...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29784450/physician-assessed-and-patient-reported-urinary-morbidity-after-radio-chemotherapy-and-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer
#3
Lars Fokdal, Richard Pötter, Kathrin Kirchheiner, Jacob Chr Lindegaard, Nina Boje Kibsgaard Jensen, Christian Kirisits, Cyrus Chargari, Umesh Mahantshetty, Ina Maria Jürgenliemk-Schulz, Barbara Segedin, Peter Hoskin, Kari Tanderup
BACKGROUND AND PURPOSE: The EMBRACE study is a prospective multi-institutional study on MRI guided adaptive brachytherapy (IGABT) in locally advanced cervix cancer (LACC). This analysis describes early to late urinary morbidity assessed by physicians and patients (PRO). MATERIAL AND METHODS: A total of 1176 patients were analysed. Median follow up (FU) was 27 (1-83) months. Morbidity (CTCAE v.3) and PRO (EORTC QLQ-C30&CX24) was prospectively assessed at baseline (BL), and during FU...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29781334/surgical-treatment-of-dystonia
#4
Rubens G Cury, Suneil K Kalia, Binit B Shah, Joohi Jimenez-Shahed, L K Prashanth, Elena Moro
Treatment of dystonia should be individualized and tailored to the specific needs of patients. Surgical treatment is an important option in medically refractory cases. Several issues regarding type of the surgical intervention, targets, and predict factors of benefit are still under debate. Areas covered: To date, several clinical trials have proven the benefit and safety of deep brain stimulation (DBS) for inherited and idiopathic isolated dystonia, whereas there is still insufficient evidence in combined and acquired dystonia...
May 21, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29770292/innovative-interventional-catheterization-techniques-for-congenital-heart-disease
#5
REVIEW
Jeffrey D Zampi, Wendy Whiteside
Since 1929, when the first cardiac catheterization was safely performed in a human by Dr. Werner Forssmann (on himself), there has been a rapid progression of cardiac catheterization techniques and technologies. Today, these advances allow us to treat a wide variety of patients with congenital heart disease using minimally invasive techniques; from fetus to infants to adults, and from simple to complex congenital cardiac lesions. In this article, we will explore some of the exciting advances in cardiac catheterization for the treatment of congenital heart disease, including transcatheter valve implantation, hybrid procedures, biodegradable technologies, and magnetic resonance imaging (MRI)-guided catheterization...
April 2018: Translational pediatrics
https://www.readbyqxmd.com/read/29766770/mri-guided-thrombolysis-for-stroke-with-unknown-time-of-onset
#6
Götz Thomalla, Claus Z Simonsen, Florent Boutitie, Grethe Andersen, Yves Berthezene, Bastian Cheng, Bharath Cheripelli, Tae-Hee Cho, Franz Fazekas, Jens Fiehler, Ian Ford, Ivana Galinovic, Susanne Gellissen, Amir Golsari, Johannes Gregori, Matthias Günther, Jorge Guibernau, Karl Georg Häusler, Michael Hennerici, André Kemmling, Jacob Marstrand, Boris Modrau, Lars Neeb, Natalia Perez de la Ossa, Josep Puig, Peter Ringleb, Pascal Roy, Enno Scheel, Wouter Schonewille, Joaquin Serena, Stefan Sunaert, Kersten Villringer, Anke Wouters, Vincent Thijs, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Christian Gerloff
Background Under current guidelines, intravenous thrombolysis is used to treat acute stroke only if it can be ascertained that the time since the onset of symptoms was less than 4.5 hours. We sought to determine whether patients with stroke with an unknown time of onset and features suggesting recent cerebral infarction on magnetic resonance imaging (MRI) would benefit from thrombolysis with the use of intravenous alteplase. Methods In a multicenter trial, we randomly assigned patients who had an unknown time of onset of stroke to receive either intravenous alteplase or placebo...
May 16, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29766752/mri-guided-intravenous-alteplase-for-stroke-still-stuck-in-time
#7
Tudor G Jovin
No abstract text is available yet for this article.
May 16, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29765792/stereotactic-mri-guided-adaptive-radiation-therapy-smart-for-locally-advanced-pancreatic-cancer-a-promising-approach
#8
Elaine Luterstein, Minsong Cao, James Lamb, Ann C Raldow, Daniel A Low, Michael L Steinberg, Percy Lee
Locally advanced pancreatic cancer (LAPC) is characterized by poor prognosis and low response durability with standard-of-care chemotherapy or chemoradiotherapy treatment. Stereotactic body radiation therapy (SBRT), which has a shorter treatment course than conventionally fractionated radiotherapy and allows for better integration with systemic therapy, may confer a survival benefit but is limited by gastrointestinal toxicity. Stereotactic MRI-guided adaptive radiation therapy (SMART) has recently gained attention for its potential to increase treatment precision and thus minimize this toxicity through continuous real-time soft-tissue imaging during radiotherapy...
March 14, 2018: Curēus
https://www.readbyqxmd.com/read/29762138/theranostic-gold-magnetite-hybrid-nanoparticles-for-mri-guided-radiosensitization
#9
Devid Maniglio, Filippo Benetti, Luca Minati, Jorge Jovicich, Aldo Valentini, G Speranza, Claudio Migliaresi
The main limitation of drug-enhanced radiotherapy concerns the difficulty to evaluate the effectiveness of cancer targeting after drug administration hindering the standardization of therapies based on current radiosensitizing compounds. The challenge regards the development of systems able to combine imaging and radiotherapy enhancement in order to perform highly reliable cancer theragnosis. For these reasons, gold-magnetite hybrid nanoparticles are proposed as innovative theranostic nanotools for imaging-guided radiosensitization in cancer treatment...
May 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29759775/real-time-x-mri-guided-left-ventricular-lead-implantation-for-targeted-delivery-of-cardiac-resynchronization-therapy
#10
Jonathan M Behar, Peter Mountney, Daniel Toth, Sabrina Reiml, Maria Panayiotou, Alexander Brost, Bernhard Fahn, Rashed Karim, Simon Claridge, Tom Jackson, Ben Sieniewicz, Nik Patel, Mark O'Neill, Reza Razavi, Kawal Rhode, Christopher Aldo Rinaldi
OBJECTIVES: This study sought to test the feasibility of a purpose-built, integrated software platform to process, analyze, and overlay cardiac magnetic resonance (CMR) data in real time within a combined cardiac catheter laboratory and magnetic resonance imaging scanner suite (X-MRI) to guide left ventricular (LV) lead implantation. BACKGROUND: Suboptimal LV lead position is a major determinant of poor cardiac resynchronization therapy (CRT) response, and the optimal site is highly patient specific...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29758089/current-commercial-techniques-for-mri-guided-attenuation-correction-are-insufficient-and-will-limit-the-wider-acceptance-of-pet-mri-technology-in-the-clinic
#11
Ciprian Catana, Harald H Quick, Habib Zaidi
Whole-body hybrid PET/MR imaging has been used since its introduction in 2010 in clinical and research settings for diagnosis, staging and restaging, assessment of response to treatment and radiation therapy planning. However, the quantitative potential of PET/MRI is challenged by the lack of reliable and accurate MRI-guided attenuation correction (MRAC) owing to the lack of direct relationship between MRI signal, reflecting proton density and relaxation time properties, and electron density, which is linked to photon attenuation properties of biological tissues...
May 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29757471/image-based-retrospective-4d-mri-in-external-beam-radiotherapy-a-comparative-study-with-a-digital-phantom
#12
Chiara Paganelli, John Kipritidis, Danny Lee, Guido Baroni, Paul Keall, Marco Riboldi
PURPOSE: Several image-based retrospective sorting methods of 4D Magnetic Resonance Imaging (4D MRI) have been proposed for respiratory motion reconstruction in external beam radiotherapy. However, the optimal strategy for providing accurate and artefact-free 4D MRI, ideally corresponding to an average breathing cycle, is not yet defined. This study presents a proactive comparison of three published image-based sorting methods, to define a groundwork for benchmarking in 4D MRI. METHODS: Three published 4D MRI methods were selected for image retrospective sorting; body area, mutual information and navigator slice...
May 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29753549/respiratory-motion-resolved-self-gated-4d-mri-using-rotating-cartesian-k-space-rock-initial-clinical-experience-on-an-mri-guided-radiotherapy-system
#13
Fei Han, Ziwu Zhou, Dongsu Du, Yu Gao, Shams Rashid, Minsong Cao, Narek Shaverdian, John V Hegde, Michael Steinberg, Percy Lee, Ann Raldow, Daniel A Low, Ke Sheng, Yingli Yang, Peng Hu
PURPOSE: To optimize and evaluate the respiratory motion-resolved, self-gated 4D-MRI using Rotating Cartesian K-space (ROCK-4D-MRI) method in a 0.35 T MRI-guided radiotherapy (MRgRT) system. METHODS AND MATERIALS: The study included seven patients with abdominal tumors treated on the MRgRT system. ROCK-4D-MRI and 2D-CINE, was performed immediately after one of the treatment fractions. Motion quantification based on 4D-MRI was compared with those based on 2D-CINE...
May 9, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29752976/can-dynamic-contrast-enhanced-mri-evaluate-vegf-expression-in-brain-glioma-an-mri-guided-stereotactic-biopsy-study
#14
Ningning Di, Wenna Cheng, Xingyue Jiang, Xinjiang Liu, Jinliang Zhou, Qian Xie, Zhihui Chu, Huacheng Chen, Bin Wang
PURPOSE: To investigate whether pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to evaluate vascular endothelial growth factor (VEGF) expression in brain glioma based on a point-to-point basis. MATERIALS AND METHODS: Forty-seven patients with treatment-naïve glioma received preoperative DCE-MRI before stereotactic biopsy. We histologically quantified VEGF from section of stereotactic biopsies, and co-registered biopsy locations with localized measurements of DCE-MRI parameters including volume transfer coefficient (Ktrans ), reverse reflux rate constant (Kep), extracellular extravascular volume fraction (Ve) and blood plasma volume (Vp)...
May 9, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29730155/an-innovative-therapeutic-approach-for-malignant-mesothelioma-treatment-based-on-the-use-of-gd-boron-multimodal-probes-for-mri-guided-bnct
#15
Diego Alberti, Annamaria Deagostino, Antonio Toppino, Nicoletta Protti, Silva Bortolussi, Saverio Altieri, Silvio Aime, Simonetta Geninatti Crich
The aim of this study is to develop an innovative imaging guided approach based on Boron Neutron Capture Therapy, for the treatment of mesothelioma, assisted by the quantification of the in vivo boron distribution by MRI. The herein reported results demonstrate that overexpressed Low Density Lipoproteins receptors can be successfully exploited to deliver to mesothelioma cells a therapeutic dose of boron (26 μg/g), significantly higher than in the surrounding tissue (3.5 μg/g). Boron and Gd cells uptake was assessed by ICP-MS and MRI on two mesothelioma (ZL34, AE17) and two healthy (MRC-5 and NMuMg) cell lines...
May 3, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29727287/direct-regularization-from-co-registered-contrast-mri-improves-image-quality-of-mri-guided-near-infrared-spectral-tomography-of-breast-lesions
#16
Limin Zhang, Shudong Jiang, Yan Zhao, Jinchao Feng, Brian W Pogue, Keith D Paulsen
An approach using direct regularization from co-registered dynamic contrast enhanced magnetic reson- ance images was used to reconstruct near-infrared spectral tomography patient images, which does not need image segmentation. 20 patients with mammography/ultrasound confirmed breast abnormalities were involved in this paper, and the resulting images indicated that tumor total hemoglobin concentration contrast differentiated malignant from benign cases (p-value = 0.021). The approach prod- uced reconstructed images, which significantly reduced surface artifacts near the source-detector locations (p-value = 4...
May 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29709434/no-effect-of-music-on-anxiety-and-pain-during-transrectal-prostate-biopsies-a-randomized-trial
#17
Vignesh T Packiam, Charles U Nottingham, Andrew J Cohen, Scott E Eggener, Glenn S Gerber
OBJECTIVE: To investigate the effect of ambient music on anxiety and pain in men undergoing prostate biopsies. METHODS: Between September 2015 and June 2016, men undergoing office transrectal prostate biopsy at our institution were randomly assigned to music (n=85) or control (n=97) groups. We examined clinical characteristics, pathologic variables, and baseline anxiety using the Trait Instrument of State-Trait Anxiety Inventory (STAI-T). Primary outcomes included anxiety assessed by State Instrument of STAI (STAI-S) and pain using a Visual Analog Scale (VAS)...
April 27, 2018: Urology
https://www.readbyqxmd.com/read/29696097/mechanical-validation-of-an-mri-compatible-stereotactic-neurosurgery-robot-in-preparation-for-pre-clinical-trials
#18
Christopher J Nycz, Radian Gondokaryono, Paulo Carvalho, Nirav Patel, Marek Wartenberg, Julie G Pilitsis, Gregory S Fischer
The use of magnetic resonance imaging (MRI) for guiding robotic surgical devices has shown great potential for performing precisely targeted and controlled interventions. To fully realize these benefits, devices must work safely within the tight confines of the MRI bore without negatively impacting image quality. Here we expand on previous work exploring MRI guided robots for neural interventions by presenting the mechanical design and assessment of a device for positioning, orienting, and inserting an interstitial ultrasound-based ablation probe...
September 2017: Proceedings of the ... IEEE/RSJ International Conference on Intelligent Robots and Systems
https://www.readbyqxmd.com/read/29687050/correlation-of-apparent-diffusion-coefficient-ratio-on-3-0-t-mri-with-prostate-cancer-gleason-score
#19
Rajeev Jyoti, Tarun Pankaj Jain, Hodo Haxhimolla, Heath Liddell, Sean Edward Barrett
Introduction: The purpose was to investigate the usefulness of ADCratio on Diffusion MRI to discriminate between benign and malignant lesions of Prostate. Methods: Images of patients who underwent in-gantry MRI guided prostate lesion biopsy were retrospectively analyzed. Prostate Cancers with 20% or more Gleason score (GS) pattern 3 + 3 = 6 in each core or any volume of higher Gleason score pattern were included. ADCratio was calculated by two reviewers for each lesion...
2018: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29686604/ultrasound-triggered-effects-of-the-microbubbles-coupled-to-gdnf-plasmid-loaded-pegylated-liposomes-in-a-rat-model-of-parkinson-s-disease
#20
Peijian Yue, Wang Miao, Lin Gao, Xinyu Zhao, Junfang Teng
Background: The purpose of this study was to investigate ultrasound-triggered effects of PEGylated liposomes-coupled microbubbles mediated gene transfer of glial cell line-derived neurotrophic factor (GDNF) plasmid (PLs-GDNF-MBs) on behavioral deficits and neuron loss in a rat model of Parkinson's disease (PD). Methods: The unloaded PLs-MBs were characterized for particle size, concentration and zeta potential. PD rat model was established by a unilateral 6-hydroxydopamine (6-OHDA) lesion. Rotational, climbing pole, and suspension tests were used to evaluate behavioral deficits...
2018: Frontiers in Neuroscience
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