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Chen Du, Ningli Chai, Enqiang Linghu, Ying Gao, Zhenjuan Li, Longsong Li, Yaqi Zhai, Zhongsheng Lu, Jiangyun Meng, Ping Tang
BACKGROUND AND AIMS: Submucosal tunneling endoscopic resection (STER) is increasingly used for the treatment of submucosal tumors (SMTs) originating from the muscularis propria layer; however, endoscopic submucosal excavation (ESE) is still performed in many hospitals for its low-skill and experience requirements. This study aimed to compare STER with ESE for cardial SMTs. METHODS: From March 2013 to February 2017, patients with cardial SMTs undergoing STER (n = 47) and ESE (n = 40) were retrospectively assessed...
May 15, 2018: Surgical Endoscopy
Sharon Chiang, Tanu Garg, Austin Hu, Hitha Amin, Alfredo Davalos-Balderas, Isabel Alfradique-Dunham, Corey E Goldsmith
No abstract text is available yet for this article.
May 15, 2018: Neurology
Björn J P van Der Ster, Nicolaas H Sperna Weiland, Berend E Westerhof, Wim J Stok, Johannes J van Lieshout
Heart rate (HR) has an impact on the central blood pressure (BP) wave shape and is related to pulse wave velocity and therefore to timing and duration of systole and diastole. This study tested the hypothesis that in healthy subjects both in rest and during sympathetic stimulation the relation between HR and pulse pressure (PP) is described by a linear effect model. Forty-four healthy volunteers were subjected to sympathetic stimulation by continuous lower body negative pressure (LBNP) until the onset of pre-syncopal symptoms...
2018: Frontiers in Physiology
Joshua Sheehan, Jessica Tate, Ryan Mott, Carol Geer, Rachel Wolfe, Roy E Strowd, Amy Guzik
OBJECTIVE: To highlight the importance of a broad differential and histopathologic confirmation in patients with newly diagnosed cancer with brain lesions atypical for CNS metastasis. METHODS: We report 2 cases of biopsy-proven CNS vasculitis in patients undergoing treatment for a newly diagnosed nonmetastatic cancer. Comprehensive medical record review was performed to identify the clinical presentation, representative neuroimaging, histopathologic features, and response to treatment...
April 24, 2018: Neurology
Ningli Chai, Wengang Zhang, En-Qiang Linghu
A 28-year-old woman was found a submucosal mass in the greater curvature of prepyloric area under EUS (Figure 1). Submucosal tunneling endoscopic resection (STER)1, 2 was performed, and the procedure began with the creation of an inverse T entry (transverse entry incision, 1.0 cm; longitudinal entry incision, 0.5 cm)3 ; Subsequently, a submucosal tunnel of 4 cm was established, and ended about 0.5 cm distal to the mass; Afterward, the mass was extracted by a snare following on the endoscopic resection. Finally, the reversed T entry was closed by eight clips (Video 1)...
April 19, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Gabriel S Ferreira, Mario Bronzati, Max C Langer, Juliana Sterli
Pleurodires or side-necked turtles are today restricted to freshwater environments of South America, Africa-Madagascar and Australia, but in the past they were distributed much more broadly, being found also on Eurasia, India and North America, and marine environments. Two hypotheses were proposed to explain this distribution; in the first, vicariance would have shaped the current geographical distribution and, in the second, extinctions constrained a previously widespread distribution. Here, we aim to reconstruct pleurodiran biogeographic history and diversification patterns based on a new phylogenetic hypothesis recovered from the analysis of the largest morphological dataset yet compiled for the lineage, testing which biogeographical process prevailed during its evolutionary history...
March 2018: Royal Society Open Science
Marija Petek Šter, Ljiljana Cvejanov Kezunović, Milena Cojić, Davorina Petek, Igor Švab
Introduction: One of the aims of health care reform in Montenegro is to strengthen primary care. An important step forward is the implementation of specialty training in family medicine (FM). The aim of this article is to evaluate the implementation of specialty training in family medicine in Montenegro, regarding the content, structure and methods, by the first generation of trainees and the coordinator of the training. Methods: A questionnaire was sent by mail in July and August 2017 to all 26 eligible trainees who started specialty training in 2013...
June 2018: Zdravstveno Varstvo
Davorina Petek, Marija Petek-Ster, Ksenija Tusek-Bunc
Background: Health-related quality of life (HRQoL) is measuring a patient's experience of his health status and represents an outcome of medical interventions. Existing data proves that a healthy lifestyle is positively associated with HRQoL in all age groups. Patients with a high risk for cardiovascular disease typically led an unhealthy lifestyle combined with risk diseases. We aimed to analyse these characteristics and their reflection in HRQoL. Methods: A cross-sectional study in 36 family practices, stratified by location and size...
March 2018: Zdravstveno Varstvo
Yanmin Huang, Haiyan Wen, Jiahua Zheng, Chunfang Gan, Liping Pang, Chunling Pang, Xiaolan Liu, Junyan Zhan, Jianguo Cui
Using cholesterol, stigmasterol and sitosterol as starting materials, a series of 7-subsitituted-ster-3-yl 2-methoxybenzoate analogs were prepared through reacting with 2-methoxybenzoyl chloride and introducing some function groups, such as carbonyl, hydroxyl and various thiosemicarbazones, at 7-position of steroidal nucleus. The structures of these new compounds were characterized by IR, NMR and HRMS. Their antiproliferative activities were evaluated by using several types of cancer cells. Interestingly, the compounds displayed potent antiproliferative activity against CNE-2 (nasopharyngeal carcinoma cell lines), BEL-7402 (human liver cancer cell lines) and HepG2 (human liver cancer cell lines), suggesting that they have potential to be drug candidates for cancer treatment...
March 30, 2018: Natural Product Research
John G Gunderson, Alan Fruzzetti, Brandon Unruh, Lois Choi-Kain
The authors review four theories that propose different conceptualizations of borderline personality disorder's (BPD) core psychopathology: excess aggression, emotional dysregulation, failed mentalization, and interpersonal hypersensitivity. The theories are compared in their ability to explain BPD's coaggregation of four usually distinct sectors of psychopathology, their high overlap with other disorders, their ability to distinguish BPD from other disorders, their integration of heritability, and their clinical applicability...
April 2018: Journal of Personality Disorders
Kerstin Schweyer, Marc Aurel Busche, Jochen Hammes, Andreas Zwergal, Carsten Buhmann, Thilo van Eimeren, Günter U Höglinger
No abstract text is available yet for this article.
March 6, 2018: Neurology
Ming-Yan Cai, Bo-Qun Zhu, Mei-Dong Xu, Wen-Zheng Qin, Yi-Qun Zhang, Wei-Feng Chen, Marie Ooi, Quan-Lin Li, Li-Qing Yao, Ping-Hong Zhou
BACKGROUND AND AIMS: The management of subepithelial tumors with a predominant extraluminal growth pattern or extra-GI tumors can be challenging and traditionally requires a surgical resection that is not only invasive but may carry a significant risk of morbidity and mortality. We aimed to assess the feasibility, safety, and efficacy of a novel endoscopic technique termed submucosal tunnel endoscopic resection for extraluminal tumors (STER-ET). METHODS: We prospectively enrolled patients who underwent STER-ET for GI subepithelial tumors with a predominant extraluminal growth pattern or extra-GI tumors located at the level of cardia or the proximal part of the lesser curvature of the stomach seen on cross-sectional imaging between January 2016 and March 2017...
February 27, 2018: Gastrointestinal Endoscopy
Shankar Kumar, Irina Chis Ster, Richard Pollok, Ivan Muscat, Timothy D Planche
We studied healthcare-associated and community-associated Clostridium difficile infection (CDI) in Jersey, Channel Islands (2008-2012). The Island's stable population has reliable denominator data, a clearly defined at-risk population, and healthcare contact that is easily followed. The vast majority of CDI cases had had recent healthcare contact, and true community-associated disease is extremely rare.Infect Control Hosp Epidemiol 2018;39:603-607.
May 2018: Infection Control and Hospital Epidemiology
Anuja Patil, Ritu Shree, Darakhshan Naheed, Manoj K Goyal, Sahil Mehta, Chirag K Ahuja, Bishan D Radotra, Vivek Lal
No abstract text is available yet for this article.
February 27, 2018: Neurology
Paul Gadient, Dimitri Archer, Negar Asdaghi
No abstract text is available yet for this article.
February 20, 2018: Neurology
Mauricio F Villamar, Farhan A Mirza, Jonathan H Smith, Vanessa D Smith
No abstract text is available yet for this article.
February 6, 2018: Neurology
Dennis Yang, Peter V Draganov
OPINION STATEMENT: "Third space" endoscopy, also commonly referred as submucosal endoscopy, is founded on the principle that the deeper layers of the gastrointestinal (GI) tract can be accessed by tunneling in the submucosal space without compromising the integrity of the overlying mucosa. Peroral endoscopic myotomy (POEM), endoscopic submucosal dissection (ESD), and submucosal tunneling endoscopic resection (STER) are innovative techniques within the field of third space endoscopy in the management of esophageal disorders...
March 2018: Current Treatment Options in Gastroenterology
Sven Streit, Jacobijn Gussekloo, Robert A Burman, Claire Collins, Biljana Gerasimovska Kitanovska, Sandra Gintere, Raquel Gómez Bravo, Kathryn Hoffmann, Claudia Iftode, Kasper L Johansen, Ngaire Kerse, Tuomas H Koskela, Sanda Kreitmayer Peštić, Donata Kurpas, Christian D Mallen, Hubert Maisonneuve, Christoph Merlo, Yolanda Mueller, Christiane Muth, Rafael H Ornelas, Marija Petek Šter, Ferdinando Petrazzuoli, Thomas Rosemann, Martin Sattler, Zuzana Švadlenková, Athina Tatsioni, Hans Thulesius, Victoria Tkachenko, Peter Torzsa, Rosy Tsopra, Canan Tuz, Marjolein Verschoor, Rita P A Viegas, Shlomo Vinker, Margot W M de Waal, Andreas Zeller, Nicolas Rodondi, Rosalinde K E Poortvliet
OBJECTIVES: We previously found large variations in general practitioner (GP) hypertension treatment probability in oldest-old (>80 years) between countries. We wanted to explore whether differences in country-specific cardiovascular disease (CVD) burden and life expectancy could explain the differences. DESIGN: This is a survey study using case-vignettes of oldest-old patients with different comorbidities and blood pressure levels. An ecological multilevel model analysis was performed...
March 2018: Scandinavian Journal of Primary Health Care
Martin Kronenbuerger, Alessandro Olivi, David S Zee
No abstract text is available yet for this article.
January 23, 2018: Neurology
Shunzhe Song, Xu Wang, Shen Zhang, Yanxia Li, Xiaonan Zhang, Xufang Chu
BACKGROUND:  Submucosal tunneling endoscopic resection (STER) has emerged as a feasible technique for resecting upper gastrointestinal (GI) tract submucosal tumors (SMTs) through natural orifice transluminal endoscopic surgery. STER reduces the risk of postoperative perforation and abdominal infections and promotes rapid wound healing. The aim of this meta-analysis was to evaluate the safety and efficacy of STER for small (≤ 3.5 cm) upper GI SMTs and explore the potential factors influencing STER's efficacy and complication rate...
April 2018: Zeitschrift Für Gastroenterologie
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