Ayana E Morales, Ruby Gumenick, Caitlyn M Genovese, Yun Yeong Jang, Ariene Ouedraogo, Maite Ibáñez de Garayo, Tania Pannellini, Sanjay Patel, Matthew E Bott, Julio Alvarez, Sung Soo Mun, Jennifer Totonchy, Archana Gautam, Jesus Delgado de la Mora, Stephanie Chang, Dagmar Wirth, Marcelo Horenstein, Tao Dao, David A Scheinberg, Paul G Rubinstein, Aggrey Semeere, Jeffrey Martin, Catherine C Godfrey, Carlee B Moser, Roy M Matining, Thomas B Campbell, Margaret Z Borok, Susan E Krown, Ethel Cesarman
In people living with HIV, Kaposi Sarcoma (KS), a vascular neoplasm caused by the KS herpesvirus (KSHV/HHV-8), remains the most common malignancy worldwide. Individuals living with HIV, receiving otherwise effective antiretroviral therapy, may present with extensive disease requiring chemotherapy. Hence, new therapeutic approaches are needed. The Wilms' tumor 1 (WT1) protein is overexpressed and associated with poor prognosis in several hematologic and solid malignancies and has shown promise as an immunotherapeutic target...
January 8, 2024: PLoS Pathogens