keyword
https://read.qxmd.com/read/38317342/pretransplant-malignancy-in-pediatrics-is-not-a-risk-factor-for-renal-graft-failure
#21
JOURNAL ARTICLE
Asher Mandel, Samuel G Robinson, Benjamin Peticca, Tomas M Prudencio, Sunil S Karhadkar
BACKGROUND: In adults, pretransplant malignancy (PTM) negatively impacts patient survival due to immunosuppression regimens influencing post-transplantation tumor growth. Few reports investigate the outcomes of pediatric kidney transplantation with PTM. We compare transplant outcomes for pediatric patients with PTM to matched controls, including cancer types extending beyond Wilms tumor. METHODS: The United Network of Organ Sharing Database was queried to identify pediatric transplant recipients with histories of PTM...
February 2024: Pediatric Transplantation
https://read.qxmd.com/read/38302330/lsd1-promotes-the-fsh-responsive-follicle-formation-by-regulating-autophagy-and-repressing-wt1-in-the-granulosa-cells
#22
JOURNAL ARTICLE
Zijian Zhu, Meina He, Tuo Zhang, Ting Zhao, Shaogang Qin, Meng Gao, Wenji Wang, Wenying Zheng, Ziqi Chen, Longping Liu, Ming Hao, Bo Zhou, Hua Zhang, Jianbin Wang, Fengchao Wang, Guoliang Xia, Chao Wang
In a growing follicle, the survival and maturation of the oocyte largely depend on support from somatic cells to facilitate FSH-induced mutual signaling and chemical communication. Although apoptosis and autophagy in somatic cells are involved in the process of FSH-induced follicular development, the underlying mechanisms require substantial study. According to our study, along with FSH-induced antral follicles (AFs) formation, both lysine-specific demethylase 1 (LSD1) protein levels and autophagy increased simultaneously in granulosa cells (GCs) in a time-dependent manner, we therefore evaluated the importance of LSD1 upon facilitating the formation of AFs correlated to autophagy in GCs...
January 17, 2024: Science Bulletin
https://read.qxmd.com/read/38300383/wt1-and-tp53-as-valuable-diagnostic-biomarkers-for-relapse-after-hematopoietic-stem-cell-transplantation-in-acute-myeloid-leukemia
#23
JOURNAL ARTICLE
Ali Asghari-Ghomi, Faranak Fallahian, Javad Garavand, Mohammad Hossein Mohammadi
BACKGROUND: Relapse following hematopoietic stem cell transplantation (HSCT) occurs relatively frequently and is a significant risk factor for mortality in patients with acute myeloid leukemia (AML). Early diagnosis is, therefore, of utmost importance and can provide valuable guidance for appropriate and timely intervention. Here, the diagnostic value of two molecular markers, Wilms tumor 1 (WT1) and tumor suppressor protein p53 (TP53), were studied. METHODS AND RESULTS: Twenty AML patients undergoing HSCT participated in this investigation...
February 1, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38280040/bap1-wilms-tumor-1-and-calretinin-in-predicting-survival-and-response-to-first-line-chemotherapy-in-patients-with-pleural-mesothelioma
#24
JOURNAL ARTICLE
Tuna Han Yuce, Guntulu Ak, Selma Metintas, Emine Dundar, Oluf Dimitri Roe, Vasiliki Panou, Muzaffer Metintas
PURPOSE: There are currently no methods to predict response to chemotherapy in pleural mesothelioma (PM). The aim of this study is to investigate the predictive and prognostic role of BAP1, WT1 and calretinin expression and their combinations in pre-treatment tumor samples by immunohistochemical (IHC) staining. METHODS: The study included consecutive PM patients treated with chemotherapy alone at a University hospital between 2009 and 2020. BAP1 analyses were performed on formalin-fixed, paraffin-embedded tumor tissue samples of the patients, while WT1 and calretinin information were obtained from the histopathological diagnosis records...
January 27, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38264368/dosimetric-comparison-of-3d-conformal-radiotherapy-3d-crt-intensity-modulated-radiotherapy-imrt-and-volumetric-modulated-arc-therapy-vmat-in-cardiac-sparing-whole-lung-irradiation
#25
JOURNAL ARTICLE
Ryohei Yamauchi, Shinobu Akiyama, Norifumi Mizuno, Takako Kobayashi, Tomoko Itazawa, Tomoyuki Masuda, Miki Hirano, Fumihiro Tomita, Yosuke Hosoya, Jiro Kawamori
Introduction Whole lung irradiation (WLI) is used for the treatment of lung metastasis in Wilms tumor and Ewing sarcoma; however, cardiac complications are one of the concerns. We report the dosimetric advantages of WLI using volumetric-modulated arc therapy (VMAT) and present a dosimetric comparison of VMAT with anteroposterior-posteroanterior (AP-PA) and static-field intensity-modulated radiation therapy (IMRT). Additionally, we evaluated the dosimetric impact of respiratory motion and intra-fractional motion during VMAT treatment...
December 2023: Curēus
https://read.qxmd.com/read/38259681/emergency-angioembolization-for-life-threatening-hemorrhage-in-wilms-tumor
#26
Areej Salim, Sajid Ali, Muhammad Ali Sheikh, Tariq Latif, Islah Ud Din
INTRODUCTION: Renal artery embolization has been used in a palliative fashion for symptomatic relief of hematuria or flank pain in unresectable renal cell carcinoma in adults. There is limited data on the use of embolization for actively bleeding and unresectable tumors in the oncological pediatric population. CASE DESCRIPTION: A previously healthy 5-year-old boy with no significant past medical or surgical history presented to the clinic with gradually worsening abdominal distension associated with occasional abdominal pain, gross hematuria, and lethargy for four months...
2024: Journal of cancer & allied specialties
https://read.qxmd.com/read/38259676/association-of-wilms-tumor-with-crossed-fused-renal-ectopia-in-children-a-case-report
#27
Sajid Ali, Tariq Latif, Muhammad Ali Sheikh, Muhammad Bilal Shafiq
INTRODUCTION: Wilms tumor is the most common renal malignancy in children. The occurrence of Wilms tumor with various congenital genitourinary anomalies has been reported, particularly in horseshoe kidneys, hypospadias, disorder of sexual development, and double collecting system. However, Wilms tumor with crossed renal ectopia is a rare finding. CASE DESCRIPTION: We are reporting a case report of Wilms tumor in a 3-year-old girl who presented with a huge left flank mass with cross-fused renal ectopia...
2024: Journal of cancer & allied specialties
https://read.qxmd.com/read/38251681/race-and-ethnic-group-enrollment-and-outcomes-for-wilms-tumor-analysis-of-the-current-era-children-s-oncology-group-study-aren03b2
#28
JOURNAL ARTICLE
Harold N Lovvorn Iii, Lindsay A Renfro, Daniel J Benedetti, Meera Kotagal, Hannah M Phelps, Peter F Ehrlich, Andrea C Lo, Jesse K Sandberg, Amanda L Treece, Kenneth W Gow, Richard D Glick, Andrew M Davidoff, Nicholas G Cost, David B Dix, Conrad V Fernandez, Jeffrey S Dome, James I Geller, Elizabeth A Mullen
INTRODUCTION: To review race and ethnic group enrollment and outcomes for Wilms tumor (WT) across all four risk-assigned therapeutic trials from the current era Children's Oncology Group Renal Tumor Biology and Risk Stratification Protocol, AREN03B2. METHODS: For WT patients enrolled on AREN03B2 (2006-2019), disease and biologic features, therapeutic study-specific enrollment, and event-free (EFS) and overall (OS) 4-year survival were compared between institutionally reported race and ethnic groups...
January 22, 2024: Journal of the American College of Surgeons
https://read.qxmd.com/read/38246972/pulmonary-metastatectomy-in-pediatric-cancer-patients-at-national-cancer-institute-egypt-prognostic-factors-and-outcome
#29
JOURNAL ARTICLE
Asmaa Hamoda, Inas Elattar, Heba Mahmoud, Mohamed Abdelrahman, Emad Ebied
BACKGROUND: Metastatic tumors account for 80% of all lung tumors in children. Wilms tumour and osteosarcoma are the most tumors of childhood that produce lung metastases. The aim of the current study is to assess the prognostic factors of pulmonary metastatectomy in pediatric solid tumours as age, number, size, site,laterality, resectability of pulmonary nodules, and number of Thoracotomies. Calculate overall survival among patients who underwent pulmonary metastatectomy. METHODS: It is a retrospective study including all pediatric patients with metastatic solid tumors to lungs treated at pediatric oncology department, National Cancer Institute, Cairo University from 2008 to 2014...
January 22, 2024: Journal of the Egyptian National Cancer Institute
https://read.qxmd.com/read/38231344/bone-marrow-derived-mesenchymal-stromal-cells-obstruct-aml-targeting-cd8-%C3%A2-clonal-effector-and-car-t-cell-function-while-promoting-a-senescence-associated-phenotype
#30
JOURNAL ARTICLE
Russell Towers, Lidia Trombello, Maximilian Fusenig, Antje Tunger, Anna-Lena Baumann, Roberto Savoldelli, Rebekka Wehner, Frederick Fasslrinner, Claudia Arndt, Francesco Dazzi, Malte Von Bonin, Anja Feldmann, Michael P Bachmann, Manja Wobus, Marc Schmitz, Martin Bornhäuser
Bone marrow mesenchymal stromal cells (MSCs) have been described as potent regulators of T-cell function, though whether they could impede the effectiveness of immunotherapy against acute myeloid leukemia (AML) is still under investigation. We examine whether they could interfere with the activity of leukemia-specific clonal cytotoxic T-lymphocytes (CTLs) and chimeric antigen receptor (CAR) T cells, as well as whether the immunomodulatory properties of MSCs could be associated with the induction of T-cell senescence...
January 17, 2024: Cancer Immunology, Immunotherapy: CII
https://read.qxmd.com/read/38224851/downregulation-of-wtap-causes-dilated-cardiomyopathy-and-heart-failure
#31
JOURNAL ARTICLE
Lei Shi, Xinzhi Li, Meiwei Zhang, Cong Qin, Zhiguo Zhang, Zheng Chen
RNA binding proteins have been shown to regulate heart development and cardiac diseases. However, the detailed molecular mechanisms is not known. In this study, we identified Wilms' tumor 1-associating protein (WTAP, a key regulatory protein of the m6 A RNA methyltransferase complex) as a key regulator of heart function and cardiac diseases. WTAP is associated with heart development, and its expression is downregulated in both human and mice with heart failure. Cardiomyocyte-specific knockout of Wtap (Wtap-CKO) induces dilated cardiomyopathy, heart failure and neonatal death...
January 13, 2024: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/38223339/single-cell-transcriptomes-of-kidneys-in-a-6-month-old-boy-with-denys-drash-syndrome-reveal-stromal-cell-heterogeneity-in-the-tumor-microenvironment
#32
JOURNAL ARTICLE
Tao Li, Jiangfeng Zhou, Haiyan Wu, Xiucheng Gao, Qiyang Shen, Rui Cheng, Mingshun Zhang
BACKGROUND: Denys-Drash syndrome (DDS) is a rare disease characterized with pseudohermaphroditism, nephroblastoma (also known as Wilms tumor), and diffuse mesangial sclerosis. The therapy for DDS is largely supportive, i.e. surgery and chemotherapy for Wilms tumor and renal replacement therapy. Due to the limited understanding of the pathogenesis, precision therapy for DDS is yet to be explored. We sought to explore the cellular components and interactions in kidney tissues from an infant with DDS...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38212830/correlating-food-and-nutritional-patterns-with-cancers-in-the-pediatric-oncology-population-at-two-specialized-hospitals-in-tanzania
#33
JOURNAL ARTICLE
Dafrosa Joseph Monko, Haikael David Martin, Emmanuel Abraham Mpolya
BACKGROUND: This study of nutritional patterns in relation to cancers among pediatric oncology population in Tanzania was motivated by the lack of up-to-date information about the nutritional practices, the controversy around the importance of nutritional support and the lack of consistent nutritional criteria among pediatric oncology populations. METHODS: A survey study in two cancer referral hospitals of children diagnosed with any cancers, aged between 1 and 17 years inclusive and being eligible for enteral feeding included 131 children...
January 11, 2024: BMC Nutrition
https://read.qxmd.com/read/38201471/congenital-tumors-magnetic-resonance-imaging-findings-with-focus-on-rare-tumors
#34
JOURNAL ARTICLE
Piotr Kwasniewicz, Julia Wieczorek-Pastusiak, Anna Romaniuk-Doroszewska, Monika Bekiesinska-Figatowska
Congenital tumors are rare and, owing to this rarity, there is limited information on many of them. A total of 839 fetal and postnatal MRI studies performed in the first 3 months of life were retrospectively reviewed. They were performed with the use of 1.5 T scanners. Seventy-six tumors were diagnosed based on fetal MRI between 20 and 37 gestational weeks, and 27 were found after birth, from 1 day of age to 3 months of life. Teratomas were the most common tumors in our dataset, mainly in the sacrococcygeal region (SCT), followed by cardiac rhabdomyomas and subependymal giant cell astrocytomas (SEGA) associated with TSC, and neuroblastomas...
December 20, 2023: Cancers
https://read.qxmd.com/read/38190392/wilms-tumor-1-wt1-antigen-is-overexpressed-in-kaposi-sarcoma-and-is-regulated-by-kshv-vflip
#35
JOURNAL ARTICLE
Ayana E Morales, Ruby Gumenick, Caitlyn M Genovese, Yun Yeong Jang, Ariene Ouedraogo, Maite Ibáñez de Garayo, Tania Pannellini, Sanjay Patel, Matthew E Bott, Julio Alvarez, Sung Soo Mun, Jennifer Totonchy, Archana Gautam, Jesus Delgado de la Mora, Stephanie Chang, Dagmar Wirth, Marcelo Horenstein, Tao Dao, David A Scheinberg, Paul G Rubinstein, Aggrey Semeere, Jeffrey Martin, Catherine C Godfrey, Carlee B Moser, Roy M Matining, Thomas B Campbell, Margaret Z Borok, Susan E Krown, Ethel Cesarman
In people living with HIV, Kaposi Sarcoma (KS), a vascular neoplasm caused by the KS herpesvirus (KSHV/HHV-8), remains the most common malignancy worldwide. Individuals living with HIV, receiving otherwise effective antiretroviral therapy, may present with extensive disease requiring chemotherapy. Hence, new therapeutic approaches are needed. The Wilms' tumor 1 (WT1) protein is overexpressed and associated with poor prognosis in several hematologic and solid malignancies and has shown promise as an immunotherapeutic target...
January 8, 2024: PLoS Pathogens
https://read.qxmd.com/read/38184433/characteristics-and-clinical-outcomes-of-children-with-wilms-tumour-a-15-year-experience-in-a-single-centre-in-nigeria
#36
JOURNAL ARTICLE
Abdulrasheed A Nasir, Nurudeen T Abdur-Raheem, Lukman O Abdur-Rahman, Taibat T Ibiyeye, Tolulope O Sayomi, Olanrewaju T Adedoyin, James O Adeniran
BACKGROUND: Wilms' tumor (WT) is the most common paediatric renal tumor and is one of the most treatment-responsive solid tumours. Survival from Wilms tumour (WT) in sub-Saharan Africa remains dismal as a result of late presentation, treatment abandonment and infrastructure deficit. The purpose of this study was to analyze the clinical outcome of children with Wilms tumour managed in a Nigerian referral centre over a 15-year period. METHODS: This is a retrospective study of children with WT (nephroblastoma) who were treated at our institution between January 2006 and December 2020...
December 16, 2023: Journal of Pediatric Surgery
https://read.qxmd.com/read/38182986/ct-radiomics-to-differentiate-between-wilms-tumor-and-clear-cell-sarcoma-of-the-kidney-in-children
#37
JOURNAL ARTICLE
Yaxin Deng, Haoru Wang, Ling He
BACKGROUND: To investigate the role of CT radiomics in distinguishing Wilms tumor (WT) from clear cell sarcoma of the kidney (CCSK) in pediatric patients. METHODS: We retrospectively enrolled 83 cases of WT and 33 cases of CCSK. These cases were randomly stratified into a training set (n = 81) and a test set (n = 35). Several imaging features from the nephrographic phase were analyzed, including the maximum tumor diameter, the ratio of the maximum CT value of the tumor solid portion to the mean CT value of the contralateral renal vein (CTmax/CT renal vein), and the presence of dilated peritumoral cysts...
January 5, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38182143/microrna-193a-promotes-apoptosis-in-retinal-neuronal-cells-in-early-stage-diabetic-dm-rat-via-wilms-tumor-gene-1
#38
JOURNAL ARTICLE
Juan Yu, Kehai Che, Chong Gao, Xuemei Pu, Lijun Ren
OBJECTIVE: This study aimed to investigate the role and mechanism of microRNA (miR)-193a in promoting apoptosis of retinal neuronal cells in early diabetic (DM) rats. METHODS: Seventy-two male SD-grade rats were selected to establish a DM model by intraperitoneal injection of streptozotocin (STZ), and randomly divided into a control group (blank control group), a DM group (diabetic model group), a DM+miR-NC inhibitor group (miR-193a inhibition negative control group), a DM+miR-193a inhibitor group (miR-193a inhibitor group), DM+miR-NC mimic group (miR-193a overexpression negative control group), DM+miR-193a mimic group (miR-193a overexpression group), with12 rats in each group...
January 4, 2024: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38172596/wtap-mediated-m-6-a-modification-of-frzb-triggers-the-inflammatory-response-via-the-wnt-signaling-pathway-in-osteoarthritis
#39
JOURNAL ARTICLE
Xueying An, Rongliang Wang, Zhongyang Lv, Wenshu Wu, Ziying Sun, Rui Wu, Wenjin Yan, Qing Jiang, Xingquan Xu
Osteoarthritis (OA) is the most common form of arthritis. However, the exact pathogenesis remains unclear. Emerging evidence shows that N6-methyladenosine (m6 A) modification may have an important role in OA pathogenesis. This study aimed to investigate the role of m6 A writers and the underlying mechanisms in osteoarthritic cartilage. Among m6 A methyltransferases, Wilms tumor 1-associated protein (WTAP) expression most significantly differed in clinical osteoarthritic cartilage. WTAP regulated extracellular matrix (ECM) degradation, inflammation and antioxidation in human chondrocytes...
January 4, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38169393/pigt-promotes-cell-growth-glycolysis-and-metastasis-in-bladder-cancer-by-modulating-glut1-glycosylation-and-membrane-trafficking
#40
JOURNAL ARTICLE
Mingyue Tan, Qi Pan, Chao Yu, Xinyu Zhai, Jianyi Gu, Le Tao, Dongliang Xu
BACKGROUND: Bladder cancer is very common worldwide. PIGT is a subunit of the glycosylphosphatidylinositol transamidase which involves in tumorigenesis and invasiveness. m6A modification of mRNA has been linked to cell proliferation, tumor progression and other biological events. However, how PIGT is regulated and what is the function of PIGT in bladder cancer remains to be elucidated. METHODS: PIGT was silenced or overexpressed to study its role in regulating bladder cancer...
January 2, 2024: Journal of Translational Medicine
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