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tooth development

John R Apps, Gabriela Carreno, Jose Mario Gonzalez-Meljem, Scott Haston, Romain Guiho, Julie E Cooper, Saba Manshaei, Nital Jani, Annett Hölsken, Benedetta Pettorini, Robert J Beynon, Deborah M Simpson, Helen C Fraser, Ying Hong, Shirleen Hallang, Thomas J Stone, Alex Virasami, Andrew M Donson, David Jones, Kristian Aquilina, Helen Spoudeas, Abhijit R Joshi, Richard Grundy, Lisa C D Storer, Márta Korbonits, David A Hilton, Kyoko Tossell, Selvam Thavaraj, Mark A Ungless, Jesus Gil, Rolf Buslei, Todd Hankinson, Darren Hargrave, Colin Goding, Cynthia L Andoniadou, Paul Brogan, Thomas S Jacques, Hywel J Williams, Juan Pedro Martinez-Barbera
Adamantinomatous craniopharyngiomas (ACPs) are clinically challenging tumours, the majority of which have activating mutations in CTNNB1. They are histologically complex, showing cystic and solid components, the latter comprised of different morphological cell types (e.g. β-catenin-accumulating cluster cells and palisading epithelium), surrounded by a florid glial reaction with immune cells. Here, we have carried out RNA sequencing on 18 ACP samples and integrated these data with an existing ACP transcriptomic dataset...
March 14, 2018: Acta Neuropathologica
Kelsey H Elliott, Grethel Millington, Samantha A Brugmann
BACKGROUND: Submandibular glands (SMGs) are specialized epithelial structures which generate saliva necessary for mastication and digestion. Loss of SMGs can lead to inflammation, oral lesions, fungal infections, problems with chewing/swallowing, and tooth decay. Understanding the development of the SMG is important for developing therapeutic options for patients with impaired SMG function. Recent studies have suggested Sonic hedgehog (Shh) signaling in the epithelium plays an integral role in SMG development; however, the mechanism by which Shh influences gland development remains nebulous...
March 13, 2018: Developmental Dynamics: An Official Publication of the American Association of Anatomists
Naureen Narula, Faraz Siddiqui, Nakul Katyal, Akshay Avula, Michel Chalhoub
Internal carotid artery dissection (ICAD) accounts for 25% of cerebrovascular accidents in young and middle-aged patients. Dissection occurs when the intimal wall of an artery is damaged as a result of trauma or defect. ICAD development after dental work is a relatively uncommon phenomenon. Our study highlights a rare presentation of ICAD that resulted from a direct lidocaine nerve block injection in a patient undergoing pulpotomy for a right maxillary second premolar tooth. We have described the case and reviewed the literature on this rare but potentially life-threatening phenomenon...
January 5, 2018: Curēus
Priyam Jani, Chao Liu, Hua Zhang, Khaled Younes, M Douglas Benson, Chunlin Qin
OBJECTIVE: The bone morphogenetic proteins (BMPs) play crucial roles in tooth development. However, several BMPs retain expression in the dentin of the fully patterned and differentiated tooth. We hypothesized that BMP signaling therefore plays a role in the function of the differentiated odontoblast, the job of which is to lay down and mineralize the dentin matrix. DESIGN: We generated mice deficient in Bmp2 and 4 using a dentin matrix protein 1 (Dmp1) promoter-driven cre recombinase that was expressed in differentiated odontoblasts...
February 7, 2018: Archives of Oral Biology
Yousif A Al Dulaijan, Lei Cheng, Michael D Weir, Mary Anne S Melo, Huaibing Liu, Thomas W Oates, Lin Wang, Hockin H K Xu
OBJECTIVE: Rechargeable calcium phosphate (CaP) composites were developed recently. However, none of the rechargeable CaP composites was antibacterial. The objectives of this study were to develop the first rechargeable CaP composite that was antibacterial, and to investigate the effects of adding dimethylaminohexadecyl methacrylate (DMAHDM) into rechargeable CaP composite on ion rechargeability and re-release as well as biofilm properties. METHODS: DMAHDM was synthesized via a Menschutkin reaction...
March 8, 2018: Journal of Dentistry
Jonathan P Wiens, Gary R Goldstein, Mark Andrawis, Mijin Choi, Jennifer W Priebe
STATEMENT OF PROBLEM: Multiple definitions of centric relation (CR) have evolved over time that may have created confusion or impeded understanding. A recent attempt to achieve a singular definition by surveying the members of the Academy of Prosthodontics (AP) did not achieve majority consensus. PURPOSE: The purpose of this study was to identify those aspects or attributes within the existing definitions of CR in which there was agreement or disagreement among the members of the AP...
March 8, 2018: Journal of Prosthetic Dentistry
Melissa R Mandarakas, Kristy J Rose, Oranee Sanmaneechai, Manoj P Menezes, Kathryn M Refshauge, Joshua Burns
A functional outcome measure for infants (aged 0-3 years) with Charcot-Marie-Tooth disease (CMT) is needed for upcoming disease-modifying trials. A systematic review of outcome measures for infants with neuromuscular disorders was completed to determine if validated measures were available for the CMT infant population. We assessed 20,375 papers and identified seven functional outcome measures for infants with neuromuscular disorders. Six were developed and validated for Spinal Muscular Atrophy (SMA). There were no CMT-specific outcome measures identified, however one (Motor Function Measure) assessed a range of neuromuscular disorders including 13 infants and children with CMT...
March 9, 2018: Journal of the Peripheral Nervous System: JPNS
B K Apaydin, F Yasar
Background and Aim: Age estimation plays a significant role in forensic science, archeology, pediatric endocrinology and clinical dentistry. Tooth development is a reliable pathway for age estimation, especially in children. The aim of this study was to evaluate the accuracy of the Demirjian method (DM), Willems method (WM) and Cameriere method (CM). Materials and Methods: This study included panaramic radiographs of 330 individuals (165 girls, 165 boys) aged between 5 and 15...
March 2018: Nigerian Journal of Clinical Practice
Maytté Marcano-Caldera, Jose Luis Mejía-Cardona, José Hernán Parra Sanchez, Catalina Méndez de la Espriella, Eduardo Covo Morales, Gustavo Sierra Varón, Martha Gómez Díaz, Natalia Fortich Mesa, Paola Escobar Villegas, Patricia Bermúdez Reyes, Patricia Rodríguez Sanchez, Pedro Mejia Fernández, Ruth Ángela Gómez-Scarpetta, Vanessa Bernal Alfaro, Olga Lucia Cifuentes Aguirre, Olga Patricia López Soto, Asgeir Sigurdsson
BACKGROUND/AIM: Dental trauma in school populations has a high frequency and school teachers are often close to the place where such injuries occur. However, many studies have confirmed the lack of knowledge as to how to act in these cases. The aim of this study was to determine the knowledge in regard to dental trauma of school teachers in Colombia. MATERIALS AND METHODS: A multi-centre, descriptive cross-sectional study was performed in 251 schools using a stratified randomized sampling...
March 8, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Roshanak Ghafari, Arash Ghodousi, Esmaeil Poordavar
Tooth development is widely used for age estimation and staging physical maturity. It is of great importance in dental age estimation in forensic dentistry, orthodontic treatment planning, and pediatric endocrinology. This study aimed to compare the accuracy of two age estimation methods, i.e., the London Atlas and Smith's method, using the panoramic view of developing teeth. In this descriptive-analytic study, panoramic radiographs of 339 healthy individuals, including 145 boys and 194 girls, were assessed...
March 7, 2018: International Journal of Legal Medicine
Natalia S Moiseeva, Anatoly A Kunin
Restorative filling materials used for dental caries prevention and treatment consist of various components including monomers or oligomers, which play a significant role in forming the main structure of these materials, as well as in characterising their physical, mechanical and chemical properties. The necessity for the development and improvement of structural characteristics of polymeric dental filling materials intended for caries prevention and their life duration increase served as the initiating factor of our research...
March 2018: EPMA Journal
Raji P Grewal, Kinsi Oberoi, Leema Reddy Peddareddygari
Charcot-Marie-Tooth disease type 4C, an autosomal recessive genetic neuropathy, is caused by mutations in the SH3TC2 (SH3 domain and tetratricopeptide repeats 2) gene. Interestingly, although mutations in this gene have been observed in European gypsies, a population that originated in India, there are few publications describing Indian patients. We report our analysis of a 50-year-old woman of Asian Indian descent with onset of progressive distal weakness and sensory loss in childhood. A clinical examination revealed the presence of a neuropathy with pes cavus without spinal abnormalities...
January 2018: Case Reports in Neurology
Yoko Eguchi, Kumiko Tasato, Shinichiro Nakajima, Yoshihiro Noda, Sakiko Tsugawa, Shunichiro Shinagawa, Hidehito Niimura, Nobuyoshi Hirose, Yasumichi Arai, Masaru Mimura
BACKGROUND: Despite a steady increase in life expectancy, a few studies have investigated cross-sectional correlates and longitudinal predictors of cognitive function, a core domain of the successful aging, among socio-clinico-demographic factors in the oldest-old exclusively. OBJECTIVES: The aims of this study were to examine socio-clinico-demographic characteristics associated with global cognition and its changes in the oldest-old. METHODS: We reanalyzed a dataset of cognitively preserved community-dwelling subjects aged 85 years and older in the Tokyo Oldest Old Survey on Total Health, a 6-year longitudinal observational study...
March 7, 2018: International Journal of Geriatric Psychiatry
S Hayano, Y Fukui, N Kawanabe, K Kono, M Nakamura, Y Ishihara, H Kamioka
In developing teeth, the sequential and reciprocal interactions between epithelial and mesenchymal tissues promote stem/progenitor cell differentiation. However, the origin of the stem/progenitor cells has been the subject of considerable debate. According to recent studies, mesenchymal stem cells originate from periarterial cells and are regulated by neurons in various organs. The present study examined the role of innervation in tooth development and rodent incisor stem/progenitor cell homeostasis. Rodent incisors continuously grow throughout their lives, and the lower incisors are innervated by the inferior alveolar nerve (IAN)...
March 1, 2018: Journal of Dental Research
Déborah Lousan do Nascimento Poubel, Liliana Vicente Melo de Lucas Rezende, Júlio César Franco Almeida, Fernanda Cristina Pimentel Garcia, Isabela Porto de Toledo, Wilson Roberto Poi, Eliete Neves da Silva Guerra
BACKGROUND/AIM: Several strategies have been developed for tooth fragment reattachment following fracture. Although many techniques have been reported, there is no consensus on which one has the best results in terms of the bond strength between the fragment and the dentin over time. The aim of this study was to assess the currently reported tooth fragment reattachment techniques for fractured crowns of anterior teeth. MATERIALS AND METHODS: The PubMed, LILACS, Web of Science, Cochrane and Scopus databases were searched in October 2016, and the search was updated in February 2017...
March 7, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Xiaoling Yu, Xiaosheng Cheng, Ning Dai, Hu Chen, Changjiang Yu, Yuchun Sun
BACKGROUND AND OBJECTIVE: In dentistry, the complete denture is a conventional treatment for edentulous patients. The computer-aided design and computer-aided manufacturing (CAD/CAM) has been applied on the digital complete denture which is developed rapidly. Tooth selection and arrangement is one of the most important parts in digital complete denture. In this paper, we propose a new method of personalized teeth arrangement. METHODS: This paper presents a method of arranging teeth virtually for a complete denture...
March 2018: Computer Methods and Programs in Biomedicine
T A Elkerbout, D E Slot, C Van Loveren, G A Van der Weijden
FOCUS QUESTION: What is the efficacy of a chlorhexidine (CHX) mouthwash (MW) containing sodium fluoride (NaF) compared to a CHX - MW alone on the parameters of plaque, gingivitis and discoloration? MATERIAL AND METHODS: MEDLINE-PubMed, Cochrane-CENTRAL, and EMBASE were searched for papers from inception to December 2017. The inclusion criteria were (randomized) controlled clinical trials conducted in human subjects with good general health and without removable prosthesis...
March 7, 2018: International Journal of Dental Hygiene
Xiaoshan Wu, Lei Hu, Yan Li, Yang Li, Fu Wang, Ping Ma, Jinsong Wang, Chunmei Zhang, Canhua Jiang, Songlin Wang
The tooth root transmits and balances occlusal forces through the periodontium to the alveolar bone. The periodontium, including the gingiva, the periodontal ligament, the cementum and the partial alveolar bone, derives from the dental follicle (DF), except for the gingiva. In the early developmental stages, the DF surrounds the tooth germ as a sphere and functions to promote tooth eruption. However, the morphological dynamics and factors regulating the differentiation of the DF during root elongation remain largely unknown...
2018: International Journal of Medical Sciences
Robert L Engelmeier
Part III of this four-part series about nonanatomic denture tooth development traces the evolution of this movement from the mid-1930s through the World War II era up to the early 1950s. By this time, the general preference for posterior denture occlusion had shifted from anatomic to nonanatomic teeth, and all the major denture tooth manufacturing companies listed at least one nonanatomic design in their inventories.
March 5, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
M K Fehrenbach, U Nestler, J Meixensberger, M K Bernhard, A Merkenschlager, S Weise, M Krause
INTRODUCTION: The ciliopathy "Joubert syndrome" was first described in 1969 by Dr. Marie Joubert and most subtypes follow an autosomal recessive inheritance. The complex disorder shows typical clinical features, such as hyperventilation, abnormal eye movements, and retardation. A pathognomonic midbrain-hindbrain malformation, the molar tooth sign, can be found on magnetic resonance imaging of the brainstem. There are a little more than 200 reports of Joubert syndrome in the literature...
March 5, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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