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tooth development

James C Melville, Marcus A Couey, Matthew S Tong, Robert E Marx
Central giant cell tumors (CGCTs) are uncommon lesions occurring in the jaw. They are benign but locally destructive osteolytic lesions. They usually occur in pediatric patients 5 to 15 years of age. Multiple noninvasive modalities of treatment (intralesional steroids, interferon, calcitonin, and denosumab) have been described for those lesions, but for those that are refractory to treatment, enucleation and curettage or resection is a curative surgery. This case report describes a pediatric patient who was diagnosed with an aggressive CGCT of the left mandible encompassing the right angle to the condyle...
September 29, 2016: Journal of Oral and Maxillofacial Surgery
Magali Hernandez, Bérengère Phulpin, Ludovic Mansuy, Dominique Droz
New targeted cancer therapies such as bisphosphonates, denosumab and bevacizumab are routinely used in adult for the past decades. Their introduction into pediatric medicine is more recent that means there is a paucity of data on long-term effects on dental development and on the risk of osteonecrosis of jaw. This paper aims to outline adverse effects of new targeted cancer therapies on oral cavity including dental abnormalities observed in pediatric population treated with these molecules and the risk of osteonecrosis of the jaw (ONJ)...
October 25, 2016: Journal of Oral Pathology & Medicine
Fatemeh Momen-Heravi, Ana Babic, Shelley S Tworoger, Libin Zhang, Kana Wu, Stephanie A Smith-Warner, Shuji Ogino, Andrew T Chan, Jeffrey Meyerhardt, Edward Giovannucci, Charles Fuchs, Eunyoung Cho, Dominique S Michaud, Meir J Stampfer, Yau-Hua Yu, David Kim, Xuehong Zhang
Periodontal diseases including tooth loss might increase systemic inflammation, lead to immune dysregulation, and alter gut microbiota, thereby possibly influencing colorectal carcinogenesis. Few epidemiological studies have examined the association between periodontal diseases and colorectal cancer (CRC) risk. We collected information on the periodontal disease (defined as history of periodontal bone loss) and number of natural teeth in the Nurses' Health Study. A total of 77,443 women were followed since 1992...
October 25, 2016: International Journal of Cancer. Journal International du Cancer
G Notarbartolo di Sciara
Despite being a small part of the world's oceans, the Mediterranean Sea hosts a diverse marine mammal fauna, with a total of 28 different species known to occur, or to have occurred, in the region. Species currently recognised as regular in the Mediterranean-the Mediterranean monk seal (Monachus monachus) and 11 cetaceans (fin whale, Balaenoptera physalus; sperm whale, Physeter macrocephalus; Cuvier's beaked whale, Ziphius cavirostris; short-beaked common dolphin, Delphinus delphis; long-finned pilot whale, Globicephala melas; Risso's dolphin, Grampus griseus; killer whale, Orcinus orca; striped dolphin, Stenella coeruleoalba; rough-toothed dolphin, Steno bredanensis; common bottlenose dolphin, Tursiops truncatus; harbour porpoise, Phocoena phocoena relicta) have adapted well to the region's environmental conditions, but their coexistence with humans is problematic...
2016: Advances in Marine Biology
Sylvia Spivakovsky
Data sourcesCochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, CANCERLIT, CINAHL, the US National Institutes of Health Trials Registry and the WHO Clinical Trials Registry Platform.Study selectionRandomised controlled trials (RCTs) assessing the effects of oral cryotherapy in patients with cancer receiving treatment compared to usual care, no treatment or other interventions to prevent mucositis. The primary outcome was incidence of mucositis and its severity...
September 2016: Evidence-based Dentistry
Takashi Nakamura, Yuta Chiba, Masahiro Naruse, Kan Saito, Hidemitsu Harada, Satoshi Fukumoto
Tooth crown morphogenesis is tightly regulated by the proliferation and differentiation of dental epithelial cells. Globoside (Gb4), a globo-series glycosphingolipid, is highly expressed during embryogenesis as well as organogenesis, including tooth development. We previously reported that Gb4 is dominantly expressed in the neutral lipid fraction of dental epithelial cells. However, because its functional role in tooth development remains unknown, we investigated the involvement of Gb4 in dental epithelial cell differentiation...
October 21, 2016: International Journal of Oral Science
Ambar W Raut, Vijay Mantri, Shubham Kala, Radha A Raut
Dens invaginatus is a developmental anomaly resulting in an infolding of the enamel organ into the dental papilla prior to calcification of the dental tissues. The invagination predisposes the tooth for the development of dental caries. Conventional radiographs do not provide detailed information concerning the three-dimensional image, which would help the clinician in making a confirmatory diagnosis and planning the treatment before undertaking the actual treatment. This report describes a case where Oehlers type II dens invaginatus was diagnosed with the help of spiral computed tomography...
September 2016: Journal of Oral Biology and Craniofacial Research
L Paglia
Despite the general advances in dental care, dental caries is still a global health problem affecting many children. Occlusal surfaces of first permanent molars are the most susceptible sites in the developing permanent dentition. Dentists should use sealants or fluoride varnish - as well as other means - to limit the onset of tooth decay. Application of sealants is a recommended procedure to prevent or control caries. Sealing occlusal surfaces of newly erupted permanent molars in children and teenagers delays caries onset up to 48 months compared with unsealed teeth...
September 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
Masakazu Asahara, Masahiro Koizumi, Thomas E Macrini, Suzanne J Hand, Michael Archer
The modern platypus, Ornithorhynchus anatinus, has an eye structure similar to aquatic mammals; however, platypuses also have a "sixth sense" associated with the bill electro- and mechanoreception that they use without opening their eyes underwater. We hypothesize that Ornithorhynchus and the Miocene taxon Obdurodon have different sensory capacities, which may have resulted from differences in foraging behavior. To estimate differences in foraging, sensory systems, and anatomical divergence between these monotremes, we compared their skull morphologies...
October 2016: Science Advances
Masaaki Ikeda, Yoshitaka Yoshimura, Takashi Kikuiri, Mino Matsuno, Tomokazu Hasegawa, Kumu Fukushima, Takako Hayakawa, Hajime Minamikawa, Kuniaki Suzuki, Junichiro Iida
Bone remodeling is an important factor in orthodontic tooth movement. During orthodontic treatment, osteoclasts are subjected to various mechanical stimuli, and this promotes or inhibits osteoclast differentiation and fusion. It has been previously reported that the release from tensile force induces osteoclast differentiation. However, little is known about how release from compressive force affects osteoclasts. The present study investigated the effects of release from compressive force on osteoclasts. The number of tartrate‑resistant acid phosphatase (TRAP)‑positive multinucleated osteoclasts derived from RAW264...
October 5, 2016: Molecular Medicine Reports
Veerasamy Yengopal, Soraya Yasin Harnekar, Naren Patel, Nandi Siegfried
BACKGROUND: Childhood caries (tooth decay) consists of a form of tooth decay that affects the milk teeth (also known as baby or primary teeth) of children. This may range from tooth decay in a single tooth to rampant caries affecting all the teeth in the mouth. Primary teeth in young children are vital to their development and every effort should be made to retain these teeth for as long as is possible. Dental fillings or restorations have been used as an intervention to repair these damaged teeth...
October 17, 2016: Cochrane Database of Systematic Reviews
Christian Walter, Bilal Al-Nawas, Tim Wolff, Eik Schiegnitz, Knut A Grötz
OBJECTIVE: Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is triggered by inflammatory processes. Typical trigger factors are periodontal disease, denture pressure sores, and surgical interventions such as tooth extractions. Unfortunately there is only little data on how to proceed with implant therapy in patients with bisphosphonate treatment. This topic is not addressed in the German guidelines on medication-associated osteonecrosis. Therefore a systematic literature review was performed...
December 2016: Int J Implant Dent
P Wetselaar
Numerous ranking systems exist for the quantification of tooth wear, each unfortunately with its own particular shortcomings. In this dissertation a new and very comprehensive tooth wear evaluation system is described. In it, the existing terminology is adapted to distinguish among mechanical-intrinsic (formerly attrition), mechanical-extrinsic (formerly abrasion), chemical-intrinsic (formerly erosion) and chemical-extrinsic (formerly erosion). In order to indicate the degree of wear, the terms mild, moderate, serious and severe are used...
October 2016: Nederlands Tijdschrift Voor Tandheelkunde
Shunichi Suzuki, Eduardo Enrique Castrillon-Watanabe, Taro Arima, Yoshimasa Kitagawa, Peter Svensson
BACKGROUND: Myofascial pain associated with temporomandibular disorders has often been linked to pathological muscle hyperactivity. As a result, localized disturbances of intramuscular blood flow could lead to a lower level of oxygen distribution, hypoxia and microcirculatory changes. AIM: To assess hemodynamic changes in the masseter muscle during sustained elevated muscle activity (SEMA). MATERIALS AND METHODS: Sixteen healthy participants performed thirty 1-minute bouts of SEMA with intervals of 1-minute "rest" periods between the bouts on a bite force transducer device...
October 15, 2016: Journal of Oral Rehabilitation
Mahdi Gholami, Reza Shahakbari, Somayeh Abdolahpour, Masoud Hatami, Azam Roshanmir
INTRODUCTION: Herpes zoster Infection (HZI) is a viral disease with painful skin rashes and blisters in a limited area on one side of the body, often in a strip. Osteonecrosis with spontaneous exfoliation of teeth in association with HZI of the mandibular nerve is a rare phenomenon. In this report, such an unusual complication of HZI is presented. CASE REPORT: The clinical course of a 53-year-old woman and a 54-year-old man with HZI associated with alveolar bone necrosis and tooth exfoliation were reviewed in order to develop a patient profile for this rare combination of physical findings...
September 2016: Iranian Journal of Otorhinolaryngology
Renato Quirino Ramos, João Luiz Bastos, Marco Aurélio Peres
Population-based studies assessing self-reported periodontal questions in low-income countries are lacking, and therefore we aimed to assess the accuracy of self-reported periodontal items in Brazil. One thousand one hundred and forty adults from Florianópolis, Brazil, had their periodontium clinically examined, and responded to the following self-reported items on periodontal conditions: Question (Q)1, Do you have any wobbly teeth?; Q2, Do your gums usually bleed?; and Q3, Has your dentist ever told you that you have gum disease? Periodontitis was defined as: a...
October 10, 2016: Brazilian Oral Research
Luiz Alexandre Chisini, Marcus Cristian Muniz Conde, Jose Carlos Bernedo Alcázar, Adriana Fernandes da Silva, Jacques Eduardo Nör, Sandra Beatriz Chaves Tarquinio, Flávio Fernando Demarco
The aim of the present study was to evaluate the expression of transforming growth factor-β1 (TGF-β1) and osteonectin (ON) in pulp-like tissues developed by tissue engineering and to compare it with the expression of these proteins in pulps treated with Ca(OH)2 therapy. Tooth slices were obtained from non-carious human third molars under sterile procedures. The residual periodontal and pulp soft tissues were removed. Empty pulp spaces of the tooth slice were filled with sodium chloride particles (250-425 µm)...
October 10, 2016: Brazilian Oral Research
Alon Peled, Ofer Sarig, Liat Samuelov, Marta Bertolini, Limor Ziv, Daphna Weissglas-Volkov, Marina Eskin-Schwartz, Christopher A Adase, Natalia Malchin, Ron Bochner, Gilad Fainberg, Ilan Goldberg, Koji Sugawara, Avital Baniel, Daisuke Tsuruta, Chen Luxenburg, Noam Adir, Olivier Duverger, Maria Morasso, Stavit Shalev, Richard L Gallo, Noam Shomron, Ralf Paus, Eli Sprecher
Despite recent advances in our understanding of the pathogenesis of ectodermal dysplasias (EDs), the molecular basis of many of these disorders remains unknown. In the present study, we aimed at elucidating the genetic basis of a new form of ED featuring facial dysmorphism, scalp hypotrichosis and hypodontia. Using whole exome sequencing, we identified 2 frameshift and 2 missense mutations in TSPEAR segregating with the disease phenotype in 3 families. TSPEAR encodes the thrombospondin-type laminin G domain and EAR repeats (TSPEAR) protein, whose function is poorly understood...
October 2016: PLoS Genetics
Hang Yang, Yongli Bi, Xiaoran Shang, Mengyue Wang, Sara B Linden, Yunpeng Li, Yuhong Li, Daniel C Nelson, Hongping Wei
Streptococcus mutans often survives as a biofilm on the tooth surface and contributes to the development of dental caries. We investigated the efficacy of ClyR, an engineered chimeolysin, against S. mutans biofilms in physiological and cariogenic conditions. Susceptibility tests showed that ClyR was active against all clinical S. mutans isolates tested as well as S. mutans biofilms that displayed resistance to penicillin. S. mutans biofilms formed on hydroxyapatite discs in physiological sugar conditions and cariogenic conditions were reduced ∼2 logs and 3 logs after treatment with 100 μg/ml ClyR, respectively...
October 10, 2016: Antimicrobial Agents and Chemotherapy
Koichiro Muromachi, Hiroshi Sugiya, Nobuyuki Tani-Ishii
In postnatal dentin formation, odontoblast differentiation occurs in the pulp tissue regenerative process under pathological condition. Odontoblasts and newly differentiated odontoblast-like cells beneath the caries lesion form tertiary dentin and are highly odontogenic. To observe the activity of dentinogenesis occur within the hard tissue, a combination of immunohistological analysis and immunodetection of dentinogenesis specific molecules, such as dentin sialophosphoprotein (DSPP) and/or its cleaved products dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), is a reliable approach...
2017: Methods in Molecular Biology
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