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https://www.readbyqxmd.com/read/27932823/hereditary-dentine-dysplasias-terminology-in-the-context-of-osteogenesis-imperfecta
#1
M Chetty, T Roberts, L X G Stephen, P Beighton
Hereditary dentine dysplasias (HDD) such as dentinogenesis imperfecta (DI) and dentine dysplasia (DD) are a group of genetic conditions characterised by an abnormal dentine structure due to disturbances in the formation, composition, or organisation of the dentine matrix. Either the primary or both primary and secondary dentition are affected to varying degrees. These disorders result from mutations in the genes encoding the major protein constituents of dentine, notably collagens and phosphoproteins. The clinical and radiological features of the hereditary dentine dysplasias (HDD) are relevant to clinical dentistry, in particular osteogenesis imperfecta (OI) which is a well-known heterogeneous genetic disorder...
December 9, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27932407/torque-differences-according-to-tooth-morphology-and-bracket-placement-a-finite-element-study
#2
Spyridon N Papageorgiou, Iosif Sifakakis, Ludger Keilig, Raphael Patcas, Stefan Affolter, Theodore Eliades, Christoph Bourauel
INTRODUCTION: Torque of the maxillary incisors is essential in esthetics and proper occlusion, while torque expression is influenced by many factors. The aim of this finite element study was to assess the relative effect of tooth morphology, bracket prescription, and bracket positioning on tooth displacement and developed stresses/strains after torque application. METHODS: A three-dimensional upper right central incisor with its periodontal ligament (PDL) and alveolus was modelled...
December 8, 2016: European Journal of Orthodontics
https://www.readbyqxmd.com/read/27930937/advances-in-myelinating-glial-cell-development
#3
REVIEW
Amy L Herbert, Kelly R Monk
In the vertebrate nervous system, the fast conduction of action potentials is potentiated by the myelin sheath, a multi-lamellar, lipid-rich structure that also provides vital trophic and metabolic support to axons. Myelin is elaborated by the plasma membrane of specialized glial cells, oligodendrocytes in the central nervous system (CNS) and Schwann cells (SCs) in the peripheral nervous system (PNS). The diseases that result from damage to myelin or glia, including multiple sclerosis and Charcot-Marie-Tooth disease, underscore the importance of these cells for human health...
December 5, 2016: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/27930309/sox2-progenitors-in-sharks-link-taste-development-with-the-evolution-of-regenerative-teeth-from-denticles
#4
Kyle J Martin, Liam J Rasch, Rory L Cooper, Brian D Metscher, Zerina Johanson, Gareth J Fraser
Teeth and denticles belong to a specialized class of mineralizing epithelial appendages called odontodes. Although homology of oral teeth in jawed vertebrates is well supported, the evolutionary origin of teeth and their relationship with other odontode types is less clear. We compared the cellular and molecular mechanisms directing development of teeth and skin denticles in sharks, where both odontode types are retained. We show that teeth and denticles are deeply homologous developmental modules with equivalent underlying odontode gene regulatory networks (GRNs)...
December 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27929440/bio-photonic-detection-and-quantitative-evaluation-method-for-the-progression-of-dental-caries-using-optical-frequency-domain-imaging-method
#5
Ruchire Eranga Wijesinghe, Nam Hyun Cho, Kibeom Park, Mansik Jeon, Jeehyun Kim
The initial detection of dental caries is an essential biomedical requirement to barricade the progression of caries and tooth demineralization. The objective of this study is to introduce an optical frequency-domain imaging technique based quantitative evaluation method to calculate the volume and thickness of enamel residual, and a quantification method was developed to evaluate the total intensity fluctuation in depth direction owing to carious lesions, which can be favorable to identify the progression of dental caries in advance...
December 6, 2016: Sensors
https://www.readbyqxmd.com/read/27928242/dental-management-of-a-child-with-dentinogenesis-imperfecta-a-case-report
#6
Najmeh Akhlaghi, Ali-Reza Eshghi, Mehrnaz Mohamadpour
Dentinogenesis imperfecta (DI) is a hereditary dentin defect caused by an autosomal dominant mutation in dentin sialophosphoprotein gene. Defective dentin development results in discolored teeth that are prone to wear and fracture. Early diagnosis and proper treatment are necessary to achieve better functional and esthetic results and minimize nutritional deficiencies and psychosocial distress. In order to prevent excessive loss of tooth structure, placement of stainless steel crowns (SSCs) on deciduous and young permanent posterior teeth is recommended as soon as such teeth erupt...
March 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/27927887/surface-sensitive-microwear-texture-analysis-of-attrition-and-erosion
#7
S Ranjitkar, A Turan, C Mann, G A Gully, M Marsman, S Edwards, J A Kaidonis, C Hall, D Lekkas, P Wetselaar, A H Brook, F Lobbezoo, G C Townsend
Scale-sensitive fractal analysis of high-resolution 3-dimensional surface reconstructions of wear patterns has advanced our knowledge in evolutionary biology, and has opened up opportunities for translatory applications in clinical practice. To elucidate the microwear characteristics of attrition and erosion in worn natural teeth, we scanned 50 extracted human teeth using a confocal profiler at a high optical resolution (X-Y, 0.17 µm; Z < 3 nm). Our hypothesis was that microwear complexity would be greater in erosion and that anisotropy would be greater in attrition...
December 7, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27927885/mesenchymal-cell-community-effect-in-whole-tooth-bioengineering
#8
L Yang, A Angelova Volponi, Y Pang, P T Sharpe
In vitro expanded cell populations can contribute to bioengineered tooth formation but only as cells that respond to tooth-inductive signals. Since the success of whole tooth bioengineering is predicated on the availability of large numbers of cells, in vitro cell expansion of tooth-inducing cell populations is an essential requirement for further development of this approach. We set out to investigate if the failure of cultured mesenchyme cells to form bioengineered teeth might be rescued by the presence of uncultured cells...
December 7, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27925870/hydrogen-sulfide-enhances-pancreatic-%C3%AE-cell-differentiation-from-human-tooth-under-normal-and-glucotoxic-conditions
#9
Ioan Valentin Matei, Hisataka Ii, Ken Yaegaki
AIM: Glucotoxicity obstructs pancreatic differentiation from adult stem cells. The aim was to develop a novel protocol for differentiation of dental pulp stem cells (DPSCs) into pancreatic β cells and determine the effect of H2S on glucotoxicity. MATERIALS & METHODS: DPSCs were differentiated with media containing 5.5 or 25.0 mM glucose, exposed to 1 ng/ml H2S. Glucotoxicity, expression of β-cell markers, INS, PDX1 and GLUT2, and PI3K/AKT pathway were assessed...
December 7, 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27925236/stresses-and-strains-analysis-using-different-palatal-expander-appliances-in-upper-jaw-and-midpalatal-suture
#10
Larissa Carvalho Trojan, Libardo Andrés González-Torres, Ana Claudia Moreira Melo, Estevam Barbosa de Las Casas
Rapid maxillary expansion (RME) is the technique of increasing the transverse dimension of the upper jaw using lateral forces applied by palatal expander. Usually, this palatal appliance is anchored on posterior teeth. The purposes of this computer simulation study were to analyze the stress and strain distribution generated in the maxilla, mainly in midpalatal suture (MPS), during RME by tooth-borne and bone-borne expanders and to study the correlation between mechanical strain and Wolff's Law. The analysis was performed with finite element models developed based on Cone Beam computed tomography (CT)...
December 7, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27924851/senescence-novel-insight-into-dlx3-mutations-leading-to-enhanced-bone-formation-in-tricho-dento-osseous-syndrome
#11
Na Zhao, Dong Han, Haochen Liu, Yue Li, Sing-Wai Wong, Zhengyi Cao, Jian Xu, Xiaowei Zhang, Tao Cai, Yixiang Wang, Hailan Feng
The homeodomain transcription factor distal-less homeobox 3 gene (DLX3) is required for hair, tooth and skeletal development. DLX3 mutations have been found to be responsible for Tricho-Dento-Osseous (TDO) syndrome, characterized by kinky hair, thin-pitted enamel and increased bone density. Here we show that the DLX3 mutation (c.533 A>G; Q178R) attenuates osteogenic potential and senescence of bone mesenchymal stem cells (BMSCs) isolated from a TDO patient, providing a molecular explanation for abnormal increased bone density...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924596/methods-to-study-antagonistic-activities-among-oral-bacteria
#12
Fengxia Qi, Jens Kreth
Most bacteria in nature exist in multispecies communities known as biofilms. In the natural habitat where resources (nutrient, space, etc.) are usually limited, individual species must compete or collaborate with other neighboring species in order to perpetuate in the multispecies community. The human oral cavity is colonized by >700 microbial species known as the indigenous microbiota. This indigenous flora normally maintains an ecological balance through antagonistic as well as mutualistic interspecies interactions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27920313/previous-medicaid-expansion-may-have-had-lasting-positive-effects-on-oral-health-of-non-hispanic-black-children
#13
Brandy J Lipton, Laura R Wherry, Sarah Miller, Genevieve M Kenney, Sandra Decker
Healthy tooth development starts early in life, beginning even before birth. We present new evidence suggesting that a historic public health insurance expansion for pregnant women and children in the United States in the 1980s and 1990s may have had long-lasting effects on the oral health of the children gaining eligibility. We estimated the relationship between adult oral health and the extent of state public health insurance eligibility for pregnant women, infants, and children throughout childhood separately for non-Hispanic whites, non-Hispanic blacks, and Hispanics...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27920308/expanded-scopes-of-practice-for-dental-hygienists-associated-with-improved-oral-health-outcomes-for-adults
#14
Margaret Langelier, Tracey Continelli, Jean Moore, Bridget Baker, Simona Surdu
Dental hygienists are important members of the oral health care team, providing preventive and prophylactic services and oral health education. However, scope-of-practice parameters in some states limit their ability to provide needed services effectively. In 2001 we developed the Dental Hygiene Professional Practice Index, a numerical tool to measure the state-level professional practice environment for dental hygienists. We used the index to score state-level scopes of practice in all fifty states and the District of Columbia in 2001 and 2014...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27918905/dental-age-estimation-of-children-and-adolescents-validation-of-the-maltese-reference-data-set
#15
Hani Alsaffar, Waleed Elshehawi, Graham Roberts, Victoria Lucas, Fraser McDonald, Simon Camilleri
The purpose of this study was to validate a Reference Data Set, developed from the radiographic archives of the Dental Department, Mater Dei Hospital, Malta, for Dental Age Estimation of the Maltese population and to assess the accuracy of the method. Dental Panoramic Tomograms of 100 male and 100 females were selected. Tooth Development Stages were recorded for all 16 permanent teeth on the left and both third molars on the right. Summary and percentile data were calculated for each Tooth Development Stage and the Dental Age of each subject estimated using the unweighted average method...
November 28, 2016: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/27917906/novel-human-mutation-and-crispr-cas-genome-edited-mice-reveal-the-importance-of-c-terminal-domain-of-msx1-in-tooth-and-palate-development
#16
Silvia Naomi Mitsui, Akihiro Yasue, Kiyoshi Masuda, Takuya Naruto, Yoshiyuki Minegishi, Seiichi Oyadomari, Sumihare Noji, Issei Imoto, Eiji Tanaka
Several mutations, located mainly in the MSX1 homeodomain, have been identified in non-syndromic tooth agenesis predominantly affecting premolars and third molars. We identified a novel frameshift mutation of the highly conserved C-terminal domain of MSX1, known as Msx homology domain 6 (MH6), in a Japanese family with non-syndromic tooth agenesis. To investigate the importance of MH6 in tooth development, Msx1 was targeted in mice with CRISPR/Cas system. Although heterozygous MH6 disruption did not alter craniofacial development, homozygous mice exhibited agenesis of lower incisors with or without cleft palate at E16...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27915125/artificial-neural-networks-as-a-powerful-numerical-tool-to-classify-specific-features-of-a-tooth-based-on-3d-scan-data
#17
Stefan Raith, Eric Per Vogel, Naeema Anees, Christine Keul, Jan-Frederik Güth, Daniel Edelhoff, Horst Fischer
Chairside manufacturing based on digital image acquisition is gainingincreasing importance in dentistry. For the standardized application of these methods, it is paramount to have highly automated digital workflows that can process acquired 3D image data of dental surfaces. Artificial Neural Networks (ANNs) arenumerical methods primarily used to mimic the complex networks of neural connections in the natural brain. Our hypothesis is that an ANNcan be developed that is capable of classifying dental cusps with sufficient accuracy...
November 27, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27913821/theobromine-upregulates-osteogenesis-by-human-mesenchymal-stem-cells-in-vitro-and-accelerates-bone-development-in-rats
#18
Bret H Clough, Joni Ylostalo, Elizabeth Browder, Eoin P McNeill, Thomas J Bartosh, H Ralph Rawls, Tetsuo Nakamoto, Carl A Gregory
Theobromine (THB) is one of the major xanthine-like alkaloids found in cacao plant and a variety of other foodstuffs such as tea leaves, guarana and cola nuts. Historically, THB and its derivatives have been utilized to treat cardiac and circulatory disorders, drug-induced nephrotoxicity, proteinuria and as an immune-modulator. Our previous work demonstrated that THB has the capacity to improve the formation of hydroxyl-apatite during tooth development, suggesting that it may also enhance skeletal development...
December 2, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27913659/formative-research-using-a-community-based-participatory-research-approach-to-develop-an-oral-health-intervention-for-migrant-mexican-families
#19
Tracy L Finlayson, Padideh Asgari, Lisa Hoffman, Ana Palomo-Zerfas, Martha Gonzalez, Nannette Stamm, Maria-Isabel Rocha, Arcela Nunez-Alvarez
Oral health is a leading unmet health need among migrant families. This article describes the 1-year, community-based participatory research (CBPR) approach employed to plan and develop a Líder Communitario (lay community health worker)-led educational intervention for Mexican migrant adult caregivers and their families in three underserved, remote communities in North San Diego County, California. Four partner organizations collaborated, reviewed existing oral health curricula, and sought extensive input on educational topics and research design from key informants, migrant caregivers, and Líderes Communitarios...
December 1, 2016: Health Promotion Practice
https://www.readbyqxmd.com/read/27910930/design-of-a-hydroxyapatite-binding-antimicrobial-peptide-with-improved-retention-and-antibacterial-efficacy-for-oral-pathogen-control
#20
Zhi-Bin Huang, Xin Shi, Jing Mao, Shi-Qiang Gong
Controlling and reducing the formation of pathogenic biofilm on tooth surface is the key to the prevention and treatment of the biofilm-associated oral diseases. Antimicrobial peptides (AMPs), considered as possible future alternatives for conventional antibiotics, have been extensively studied for the control of bacterial infection. Due to the rapid dilution and degradation by human saliva, AMP preparations designed for oral use with longer retention and higher efficacy are in urgent need. To this end, a hydroxyapatite (HAp)-binding antimicrobial peptide (HBAMP), which is based on the fusion of a specific HAp-binding heptapeptide (HBP7) domain and a broad-spectrum antimicrobial peptide (KSLW) domain, has been developed in our laboratory...
December 2, 2016: Scientific Reports
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