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https://www.readbyqxmd.com/read/28727410/exosomes-mediate-epithelium-mesenchyme-crosstalk-in-organ-development
#1
Nan Jiang, Lusai Xiang, Ling He, Guodong Yang, Jinxuan Zheng, Chenglin Wang, Yimei Zhang, Sainan Wang, Yue Zhou, Tzong-Jen Sheu, Jiaqian Wu, Kenian Chen, Paulo G Coelho, Nicky M Tovar, Shin Hye Kim, Mo Chen, Yan-Heng Zhou, Jeremy J Mao
Organ development requires complex signaling by cells in different tissues. Epithelium and mesenchyme interactions are crucial for the development of the skin, hair follicles, kidney, lungs, prostate, major glands and the teeth. Despite myriad literature on cell-cell interactions and ligand-receptor binding, the roles extracellular vesicles in epithelium-mesenchyme interactions during organogenesis are poorly understood. Here, we discovered that ~100 nm exosomes were secreted by the epithelium and mesenchyme of a developing tooth organ, and diffused through the basement membrane...
July 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28727343/-hypophosphatasia
#2
Eleni Tsiantouli, Andrea Trombetti, Serge Ferrari
Hypophosphatasia (HPP) is an inborn metabolic bone disorder caused by loss-of-function mutations in the gene encoding tissue nonspecific alkaline phosphatase (TNSALP). The adult form can be mistaken with common osteoporosis and/or present recurrent metatarsal fractures, skeletal and muscular pain. Subtrochanteric femoral pseudofractures resembling bisphosphonate-associated atypical femoral fractures can also be present, and Bps are therefore contraindicated in HPP. Early tooth loss and renal calcifications can orient towards the diagnosis...
April 19, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28727163/dental-erosion-among-south-brazilian-adolescents-a-2-5-year-longitudinal-study
#3
C D Brusius, L S Alves, C Susin, M Maltz
OBJECTIVES: This population-based longitudinal study investigated the incidence, progression and risk factors for dental erosion among South Brazilian adolescents. METHODS: Eight hundred and one schoolchildren attending 42 public and private schools were clinically examined at 12 years of age; clinical examinations were repeated after 2.5 years (SD=0.3). After tooth cleaning and drying, permanent incisors and first molars were classified using the Basic Erosive Wear Examination (BEWE) scoring criteria...
July 20, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28725453/development-of-an-implementation-intention-based-intervention-to-change-children-s-and-parent-carers-behaviour
#4
Karen Davies, Christopher J Armitage, Yin-Ling Lin, James Munro, Tanya Walsh, Peter Callery
BACKGROUND: Implementation intentions enable individuals to translate good intentions into action. Parents and children can find maintaining oral health difficult, as evidenced by the presence of tooth decay. This is a common condition in children in spite of being preventable through the use of regular tooth brushing, fluoride protection and avoiding sugar intake. Even when parents and children are positive about looking after the teeth, they can face challenges in maintaining consistent habits...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28719906/a-common-ancestral-asn242ser-mutation-in-tmem67-identified-in-multiple-iranian-families-with-joubert-syndrome
#5
MohammadReza Dehghani, Majid Mojarad, Ehsan Ghayoor Karimiani, Mohammad Yahya Vahidi Mehrjardi, Afsaneh Sahebalzamani, Farah Ashrafzadeh, Mehran Beiraghi Toosi, Atiyeh Eslahi, Najmeh Ahangari, Seyed Mojtaba Yassini, Afsaneh Hassanbeigi, Azam Rasti, Seyed Mehdi Kalantar, Reza Maroofian
BACKGROUND: Joubert syndrome (JS) is a clinically and genetically heterogeneous group of rare neurodevelopmental disorder characterised by peculiar midbrain-hindbrain malformation, known as the "molar tooth" sign. JS can manifest a broad range of signs and symptoms. The most common features of JS are hypotonia, ataxia, developmental delay/intellectual disability, abnormal eye movements, and neonatal breathing abnormalities. To date, 29 genes have been shown to cause JS. METHODS: We employed whole-genome single nucleotide polymorphism genotyping in a group of Iranian families with JS and Sanger sequencing of a known mutation associated with JS located in a single homozygous regions shared by affected members of the families...
July 19, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/28717292/conservative-management-of-unicystic-ameloblastoma-in-young-patients-a-prospective-single-center-trial-and-review-of-literature
#6
Mitsu Meshram, Lalit Sagarka, Jigar Dhuvad, Sonal Anchlia, Siddharth Vyas, Harsh Shah
AIMS: The study intends to evaluate the clinical outcome of treating young patients of unicystic ameloblastoma, by various conservative treatment modalities such as marsupialization, enucleation with bone curettage and aid in establishing sound treatment guidelines. MATERIALS AND METHODS: A case series of fifteen patients is presented of unicystic ameloblastoma, who presented to our Department over the past 6 years (2010-2015) and conservative method of treatment elected in all the patients...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28713512/laboratory-evaluation-of-the-effect-of-unfilled-resin-after-the-use-of-self-etch-and-total-etch-dentin-adhesives-on-the-shear-bond-strength-of-composite-to-dentin
#7
Ehsan Baradaran Nasseri, Sara Majidinia, Davood Aghasizadeh Sharbaf
BACKGROUND: Based on the frequent application of composite resins as tooth-colored fillings, this method is considered a viable alternative to dental amalgam. However, this method has the low bond strength of the composite to dentin. To solve this issue, various dental adhesive systems with different characteristics have been developed by dentistry experts. AIM: To assess the effect of an additional layer of unfilled resin in self-etch and total-etch dentin adhesives on the shear bond strength (SBS) of composite to dentin...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28711375/the-prevalence-of-orodental-trauma-during-epileptic-seizures-in-terms-of-dental-treatment-survey-study
#8
Dominika Gawlak, Joanna Łuniewska, Wiktoria Stojak, Anahit Hovhannisyan, Anna Stróżyńska, Katarzyna Mańka-Malara, Marcin Adamiec, Andrzej Rysz
INTRODUCTION: Epilepsy is one of the most common neurological disorders. Seizures that occur during attacks may lead to head injuries. It is crucial to establish proper prophylactic management against trauma occurrence, as nowadays prevention is not sufficient. AIM: Assessment of the frequency of head and intraoral trauma during epileptic seizures and to evaluate factors that may predispose to injuries. MATERIAL AND METHODS: The questionnaire was carried out among 106 patients with epilepsy...
June 29, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28710361/the-dental-phenotype-of-hairless-dogs-with-foxi3-haploinsufficiency
#9
Kornelius Kupczik, Alexander Cagan, Silke Brauer, Martin S Fischer
Hairless dog breeds show a form of ectodermal dysplasia characterised by a lack of hair and abnormal tooth morphology. This has been attributed to a semi-dominant 7-base-pair duplication in the first exon of the forkhead box I3 gene (FOXI3) shared by all three breeds. Here, we identified this FOXI3 variant in a historical museum sample of pedigreed hairless dog skulls by using ancient DNA extraction and present the associated dental phenotype. Unlike in the coated wild type dogs, the hairless dogs were characterised in both the mandibular and maxillary dentition by a loss of the permanent canines, premolars and to some extent incisors...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28707582/the-modulation-of-micrornas-in-tooth-root-development
#10
Ran Zhang, Tiejun Li
Tooth root development begins after the completion of tooth crown development, both of them undergo a series of interactions between epithelium and the adjacent mesenchymal cells. In contrast to the study in tooth crown formation, little is known about the regulatory mechanisms of tooth root development. MicroRNAs (miRNAs) are small non-coding RNAs that regulate protein expression through post-transcriptional mechanisms. They participate in a broad aspect of biological processes from the control of development to tumorigenesis...
July 13, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28706494/rna-sequencing-analyses-demonstrate-the-involvement-of-canonical-transient-receptor-potential-channels-in-rat-tooth-germ-development
#11
Jun Yang, Wenping Cai, Xi Lu, Shangfeng Liu, Shouliang Zhao
Tooth development depends on multiple molecular interactions between the dental epithelium and mesenchyme, which are derived from ectodermal and ectomesenchymal cells, respectively. We report on a systematic RNA sequencing analysis of transcriptional expression levels from the bud to hard tissue formation stages of rat tooth germ development. We found that GNAO1, ENO1, EFNB1, CALM1, SIAH2, ATP6V0A1, KDELR2, GTPBP1, POLR2C, SORT1, and members of the canonical transient receptor potential (TRPC) channel family are involved in tooth germ development...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28703361/non-decoupled-morphological-evolution-of-the-fore-and-hindlimb-of-sabretooth-predators
#12
Alberto Martín-Serra, Borja Figueirido, Paul Palmqvist
Specialized organisms are useful for exploring the combined effects of selection of functional traits and developmental constraints on patterns of phenotypic integration. Sabretooth predators are one of the most interesting examples of specialization among mammals. Their hypertrophied, sabre-shaped upper canines and their powerfully built forelimbs have been interpreted as adaptations to a highly specialized predatory behaviour. Given that the elongated and laterally compressed canines of sabretooths were more vulnerable to fracture than the shorter canines of conical-tooth cats, it has been long hypothesized that the heavily muscled forelimbs of sabretooths were used for immobilizing prey before developing a quick and precise killing bite...
July 12, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28700256/hippo-pathway-an-emerging-regulator-of-craniofacial-and-dental-development
#13
J Wang, J F Martin
The evolutionarily conserved Hippo signaling pathway is a vital regulator of organ size that fine-tunes cell proliferation, apoptosis, and differentiation. A number of important studies have revealed critical roles of Hippo signaling and its effectors Yap (Yes-associated protein) and Taz (transcriptional coactivator with PDZ binding motif) in tissue development, homeostasis, and regeneration, as well as in tumorigenesis. In addition, recent studies have shown evidence of crosstalk between the Hippo pathway and other key signaling pathways, such as Wnt signaling, that not only regulates developmental processes but also contributes to disease pathogenesis...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28699676/influence-of-multi-wavelength-laser-irradiation-of-enamel-and-dentin-surfaces-at-0-355-2-94-and-9-4%C3%A2-%C3%AE-m-on-surface-morphology-permeability-and-acid-resistance
#14
Nai-Yuan N Chang, Jamison M Jew, Jacob C Simon, Kenneth H Chen, Robert C Lee, William A Fried, Jinny Cho, Cynthia L Darling, Daniel Fried
OBJECTIVE: Ultraviolet (UV) and infrared (IR) lasers can be used to specifically target protein, water, and mineral, respectively, in dental hard tissues to produce varying changes in surface morphology, permeability, reflectivity, and acid resistance. The purpose of this study was to explore the influence of laser irradiation and topical fluoride application on the surface morphology, permeability, reflectivity, and acid resistance of enamel and dentin to shed light on the mechanism of interaction and develop more effective treatments...
July 12, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28694781/amelogenesis-imperfecta-genes-proteins-and-pathways
#15
REVIEW
Claire E L Smith, James A Poulter, Agne Antanaviciute, Jennifer Kirkham, Steven J Brookes, Chris F Inglehearn, Alan J Mighell
Amelogenesis imperfecta (AI) is the name given to a heterogeneous group of conditions characterized by inherited developmental enamel defects. AI enamel is abnormally thin, soft, fragile, pitted and/or badly discolored, with poor function and aesthetics, causing patients problems such as early tooth loss, severe embarrassment, eating difficulties, and pain. It was first described separately from diseases of dentine nearly 80 years ago, but the underlying genetic and mechanistic basis of the condition is only now coming to light...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28694256/multiple-modes-of-lrp4-function-in-modulation-of-wnt-%C3%AE-catenin-signaling-during-tooth-development
#16
Youngwook Ahn, Carrie Sims, Megan J Murray, Paige K Kuhlmann, Jesús Fuentes-Antrás, Scott D Weatherbee, Robb Krumlauf
During development and homeostasis, precise control of Wnt/β-catenin signaling is in part achieved by secreted and membrane proteins that negatively control activity of Wnt co-receptors, Lrp5 and Lrp6. Lrp4 is related to Lrp5/6 and is implicated in modulation of Wnt/β-catenin signaling presumably through its ability to bind to the Wise (Sostdc1)/Sost (Sclerostin) family of Wnt antagonists. To gain insights into the molecular mechanisms of Lrp4 function in modulating Wnt signaling, we performed an array of genetic analyses in murine tooth development, where Lrp4 and Wise play important roles...
July 10, 2017: Development
https://www.readbyqxmd.com/read/28690486/adult-phenotype-and-rs16864880-in-the-tp63-gene-two-new-cases-and-review-of-the-literature
#17
Tânia Kawasaki de Araujo, Elaine Lustosa-Mendes, Ana P Dos Santos, Miriam Coelho Molck, Roberta Mazzariol Volpe-Aquino, Vera L Gil-da-Silva-Lopes
The TP63 gene has been described in 5 overlapping limb malformation disorders, including a rare autosomal dominant ectodermal disorder named acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome. This article describes 2 patients with ectrodactyly and variable features related to ectodermal dysplasia/ADULT syndrome, and the polymorphism rs16864880 in the TP63 gene, which was not present in their parents. The role of this variant in the genesis of this condition is discussed, based upon a review of 40 cases. The results suggested that rs16864880 may not be directly related to ADULT syndrome...
June 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/28686808/integrating-a-nurse-midwife-led-oral-health-intervention-into-centeringpregnancy-prenatal-care-results-of-a-pilot-study
#18
Sally H Adams, Steven E Gregorich, Sharon S Rising, Margaret Hutchison, Lisa H Chung
INTRODUCTION: National and professional organizations recommend oral health promotion in prenatal care to improve women's oral health. However, few prenatal programs include education about oral health promotion. The objective of this study was to determine if women receiving a brief, low-cost, and sustainable educational intervention entitled CenteringPregnancy Oral Health Promotion had clinically improved oral health compared to women receiving standard CenteringPregnancy care. METHODS: Women attending CenteringPregnancy, a group prenatal care model, at 4 health centers in the San Francisco Bay Area, participated in this nonrandomized controlled pilot study in 2010 to 2011...
July 7, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28686089/long-term-influence-of-fixed-lingual-retainers-on-the-development-of-gingival-recession-a-retrospective-longitudinal-cohort-study
#19
Jovana Juloski, Branislav Glisic, Vaska Vandevska-Radunovic
OBJECTIVE: To investigate the long-term influence of fixed lingual retainers on the development of mandibular gingival recession and to compare the prevalence with untreated individuals. MATERIALS AND METHODS: The material consisted of 144 subjects: 96 orthodontically treated patients followed for 5 years after therapy and 48 untreated age-matched subjects. The treated patients were divided in two groups: one receiving a fixed mandibular retainer (n = 48) and one receiving no form of retention in the mandible (n = 48)...
July 7, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28685531/impact-of-rantes-from-jawbone-on-chronic-fatigue-syndrome
#20
J Lechner, K Huesker, V Von Baehr
This study elucidates the question of whether chronic inflammation in the jawbone contributes to the development of Chronic Fatigue Syndrome (CFS). Fatty degenerative osteonecrosis in jawbone (FDOJ) may contribute to CFS by induction of inflammatory mediators. We examined seven cytokines by multiplex analysis in jawbone samples from two groups of patients. In order to clarify neurological interrelations, specimens from 21 CFS patients were analyzed from areas of previous surgery in the retromolar wisdom tooth area...
April 2017: Journal of Biological Regulators and Homeostatic Agents
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