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hemato oncology

Annemieke van Dongen-Leunis, W Ken Redekop, Carin A Uyl-de Groot
OBJECTIVES: The aim of this study was to assess the validity and interpretability of different preference-based questionnaires (generic 5-level EuroQol five-dimensional questionnaire [EQ-5D-5L], cancer-specific Quality of Life Questionnaire Preference-Based Measure, and European Organization of Randomized Controlled Trials 8 Dimension [EORTC-8D]) in patients with acute leukemia. METHODS: Patients who participated in Hemato-Oncologie voor Volwassenen Nederland (HOVON - the Haemato Oncology Foundation for Adults in the Netherlands) clinical trials between 1999 and 2011 at a single hospital were invited to complete the questionnaires...
September 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Maurizio Bernasconi, Alessio Casutt, Angela Koutsokera, Igor Letovanec, Frédéric Tissot, Laurent P Nicod, Alban Lovis
The role of radial-endobronchial ultrasound (R-EBUS) assisted transbronchial biopsy (TBB) for the diagnosis of peripheral pulmonary lesions is well established. However, no study has addressed its safety and value in hemato-oncological patients presenting with non-resolving infiltrates during persistent febrile neutropenia. To assess safety and feasibility of R-EBUS assisted TBB in severe thrombocytopenic and neutropenic patients. Over a period of 18 months, eight patients were assessed with R-EBUS assisted TBB after adequate platelet transfusion...
October 4, 2016: Lung
Paul Verweij, Sue Lyon
Report from the 26th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2016), 9-12 April Amsterdam, The Netherlands Invasive fungal infections are a major threat to the lives of the increasing number of immunocompromized patients, but neutropenic hemato-oncology patients are at especially high risk. Since effective antifungal treatment and prophylaxis are critical to improve survival in these patients, the emergence of antifungal drug resistance has become an increasing cause of concern...
October 3, 2016: Future Microbiology
Federico G Antillón, Jessica G Blanco, Patricia D Valverde, Mauricio Castellanos, Claudia P Garrido, Veronica Girón, Tomas R Letona, Emilia J Osorio, Dyna A Borrayo, Ricardo A Mack, Mario A Melgar, Rodolfo Lorenzana, Raul C Ribeiro, Monika Metzger, Valentino Conter, Emanuela Rossi, Maria Grazia Valsecchi
BACKGROUND: The National Pediatric Oncology Unit (UNOP) is the only pediatric hemato-oncology center in Guatemala. METHODS: Patients ages 1 to 17 years with acute lymphoblastic leukemia (ALL) were treated according to modified ALL Intercontinental Berlin-Frankfurt-Münster (IC-BFM) 2002 protocol. Risk classification was based on age, white blood cell count, immunophenotype, genetics (when available), and early response to therapy. RESULTS: From July 2007 to June 2014, 787 patients were treated, including 160 who had standard-risk ALL, 450 who had intermediate-risk ALL, and 177 who had high-risk ALL...
September 28, 2016: Cancer
Hyun Jeong Baek, Yoon Sook Cho, Kwi Suk Kim, Jin Lee, Hye Ryun Kang, Dong In Suh
In order to improve the reporting of adverse drug reactions (ADRs) as part of the routine practice at the pediatric outpatient department (OPD), we modified our ADR reporting strategy into one that facilitates the reporting process by means of a multi-disciplinary approach. In this study, we retrospectively reviewed ADR records during the period from March to September 2014 when we changed our reporting process as a part of institutional quality assurance (QA) activity. Yearly differences in the number and composition of ADRs were compared, and the descriptive analyses were done for cases reported from OPD during the QA activity in terms of the suspected drugs, type, causality, and severity of ADRs...
2016: SpringerPlus
Dorothea Evers, Jaap Jan Zwaginga, Janneke Tijmensen, Rutger A Middelburg, Masja de Haas, Karen M K de Vooght, Daan van de Kerkhof, Otto Visser, Nathalie C V Péquériaux, Francisca Hudig, Johanna G van der Bom
Red cell alloimmunization may induce severe hemolytic side effects. Identification of risk modifying conditions will help tailor preventative strategies. This study aims to quantify the associations of hematological malignancies and solid cancers with red cell alloimmunization in patients receiving red cell transfusions. We performed a nested multicenter case-control study in a source population of 24,063 patients receiving their first and subsequent red cell transfusions during an eight year follow-up period...
September 15, 2016: Haematologica
Christina Weingarten, Sarah Pliez, Eva Tschiedel, Corinna Grasemann, Carla Kreissig, Michael M Schündeln
UNLABELLED: Granulocyte transfusions for neutropenic patients have been used for over 40 years, although effectiveness, indications, and both patient and donor safety remain debated. This single-center study assessed the side effects, clinical course, and survival of granulocyte transfusions in critically ill pediatric patients, with underlying hemato-oncological disorders, prolonged neutropenia, and proven or suspected severe infection. Donor-specific side effects and influence of donor-specific characteristics on patient outcome were also investigated...
October 2016: European Journal of Pediatrics
A L Casey, T J Karpanen, P Nightingale, S Chaganti, T S J Elliott
The use of a positive-displacement needleless intravenous access device was associated with lower microbial contamination rates compared with a neutral-displacement device when used on central venous catheters in hemato-oncology patients. In addition, rates of central line-associated bloodstream infection did not differ when either device was used.
August 24, 2016: American Journal of Infection Control
Sneha Magatha Latha, Julius Xavier Scott, Satish Kumar, Suresh M Kumar, Lalitha Subramanian, Aruna Rajendran
CONTEXT: Parents report that end-of-life decisions are the most difficult treatment-related decisions that they face during their child cancer experience. Research from the parent's perspective of the quality of end-of-life care of their cancer children is scarce, particularly in developing countries like India. AIMS: This study aimed to identify the symptoms (medical/social/emotional) that most concerned parents at the end-of-life care of their cancer child and to identify the strategies parents found to be helpful during this period...
July 2016: Indian Journal of Palliative Care
Thorsten Fuereder, Danjel Koni, Andreas Gleiss, Michael Kundi, Athanasios Makristathis, Christoph Zielinski, Christoph Steininger
Evidence on risk factors for Clostridium difficile infection (CDI) in hemato-oncologic patients is conflicting. We studied risk factors for CDI in a large, well-characterized cohort of hemato-oncological patients. 144 hemato-oncological patients were identified in this retrospective, single center study with a microbiologically confirmed CDI-associated diarrhea. Patients were compared with 144 age and sex matched hemato-oncologic patients with CDI negative diarrhea. Risk factors such as prior antimicrobial therapy, type of disease, chemotherapy and survival were evaluated...
2016: Scientific Reports
Ilana Oren, Emilia Hardak, Tsila Zuckerman, Yuval Geffen, Ron Hoffman, Mordechai Yigla, Irit Avivi
OBJECTIVES: The identification of the specific pathogen responsible for a respiratory infection in patients with hematological malignancies (HM) would ensure relevant treatment and prevent toxicity associated with anti-infective therapy. This large-scale study aimed to explore the clinical impact of fiberoptic bronchoscopy with bronchoalveolar lavage (FOB-BAL) in conjunction with molecular analysis on the diagnosis and management of respiratory infections in hemato-oncological patients...
September 2016: International Journal of Infectious Diseases: IJID
Juliette Guitard, Marie-Dominique Tabone, Yaye Senghor, Cyrille Cros, Didier Moissenet, Karine Markowicz, Nadia Valin, Guy Leverger, Christophe Hennequin
OBJECTIVES: ß-D-glucan assay (BDG) has been added to the EORTC/MSG criteria for the diagnosis of invasive fungal infections (IFI), but data from pediatric populations are scarce. The aim of this study was to evaluate BDG performances in a cohort of hemato-oncological children with hematological malignancy at risk for IFI. METHODS: 113 patients were included through an 18-month period. In addition to routine IFI screening, BDG was assayed once a week. IFIs were classified using EORTC/MSG criteria w/o including the BDG results...
July 21, 2016: Journal of Infection
W Abboud, R Yahalom, M Leiba, G Greenberg, N Yarom
Multiple myeloma (MM) is a common hematological malignancy that has widespread manifestations in multiple organs, including bones and joints. This retrospective study aimed to evaluate the involvement of the temporomandibular joint (TMJ) in patients with MM. Consecutive subjects with a diagnosis of MM who presented to the oral and maxillofacial surgery clinic for routine evaluation between 2008 and 2014 were identified. Patients who had a computed tomography (CT) scan of the TMJs as part of their MM staging were included in the study...
July 1, 2016: International Journal of Oral and Maxillofacial Surgery
M E Mayerhoefer, A Haug
CLINICAL/METHODICAL ISSUE: Biomedical imaging procedures play a major role in hemato-oncological diseases with respect to pre-therapeutic staging and assessment of treatment response. STANDARD RADIOLOGICAL METHODS: Originally, the therapeutic management was the domain of computed tomography (CT) and whole-body magnetic resonance imaging (MRI). METHODICAL INNOVATIONS: Over the last decade these purely morphological techniques have gradually been replaced by hybrid imaging techniques, such as positron emission tomography-CT (PET/CT) and PET/MRI, which also provide metabolic and functional information...
July 2016: Der Radiologe
S Park, J Huh
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Louis Jacob, Maria Uvarova, Sandrine Boulet, Inva Begaj, Sylvie Chevret
BACKGROUND: Multi-Arm Multi-Stage designs aim at comparing several new treatments to a common reference, in order to select or drop any treatment arm to move forward when such evidence already exists based on interim analyses. We redesigned a Bayesian adaptive design initially proposed for dose-finding, focusing our interest in the comparison of multiple experimental drugs to a control on a binary criterion measure. METHODS: We redesigned a phase II clinical trial that randomly allocates patients across three (one control and two experimental) treatment arms to assess dropping decision rules...
2016: BMC Medical Research Methodology
Steffen Hartleif, Peter Lang, Rupert Handgretinger, Tobias Feuchtinger, Jörg Fuchs, Alfred Königsrainer, Silvio Nadalin, Ekkehard Sturm
Chronic IS is associated with significant morbidity in transplant recipients. Moreover, IS does not prevent chronic graft failure frequently. Allograft immune tolerance in LT can be induced by complete donor chimerism through allogenic HSCT combined with identical LDLT. This approach may exempt patients from chronic lifelong IS. However, it is unclear whether its benefits justify its risks. Here, we present three cases from our institution and analyze seven additional reports of children treated with HSCT/LDLT, all receiving HSCT due to hemato-oncological indications...
November 2016: Pediatric Transplantation
Sebastiano Mercadante, Andrea Costanzi, Fabrizio David, Patrizia Villari, Maurizio Musso, Paolo Marchetti, Alessandra Casuccio
BACKGROUND: In the field of hemato-oncology, there is paucity of data assessing models of integration between hemato-oncology and other partner specialties. The aim of this national survey was to gather information about the status of the integration of this kind of activity in hemato-oncologic units existing in Italy. METHODS: A national telephone survey was conducted to gather information about the status of the integration of hemato-oncologic and supportive care/anesthesiological services...
October 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Julia König, Kristina Geschwill, Andreas Lang, Felix K Tauchert, Ralf-Dieter Hofheinz, Melanie Kripp
BACKGROUND: A questionnaire-based prospective study was conducted to evaluate the current use of complementary and alternative medicine (CAM) in a hemato-oncological outpatient clinic. METHODS: A multiple-choice questionnaire was designed to assess the use of CAM in a hemato-oncological outpatient clinic. It consisted of questions on sociodemographic and general patient data, and of different kind of questions concerning the use of CAM, including disclosure rates to oncologists and general physicians...
2016: Oncology Research and Treatment
Arbnore Batalli Këpuska, Lidvana Spahiju, Ramush Bejiq, Rufadije Manqestena, Valbona Stavileci, Zana Ibraimi
OBJECTIVE: The aim of this study is to determine the differential algorithm between rheumatism and malignant diseases. For every pediatrician, to be warned when attending joint pain and child arthralgia and prevent and treat within time malignant diseases. METHODS: Our case presented in Pediatric Clinic, was referred by Regional Hospital of Ferizaj with suspected diagnose of Febris Rheumatica and Arthralgia. The main complaint was joint pain. Initially the patient was admitted at Cardiology and Rheumatology department...
April 2016: Materia Socio-medica
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