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https://www.readbyqxmd.com/read/28326848/autologous-hematopoietic-stem-cells-for-refractory-crohn-s-disease
#1
C A DiNicola, A Zand, D W Hommes
Autologous hematopoietic stem cells are gaining ground as an effective and safe treatment for treating severe refractory Crohn's disease (CD). Autologous hematopoietic stem cell therapy (AHSCT) induces resetting of the immune system by de novo regeneration of T-cell repertoire and repopulation of epithelial cells by bone-marrow derived cells to help patients achieve clinical and endoscopic remission. Areas covered: Herein, the authors discuss the use of AHSCT in treating patients with CD. Improvements in disease activity have been seen in patients with severe autoimmune disease and patients with severe CD who underwent AHSCT for a concomitant malignant hematological disease...
March 22, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28245506/should-posterior-reversible-encephalopathy-syndrome-be-mainly-considered-an-epileptic-disorder-results-of-a-sequential-neurophysiological-study-in-a-pediatric-cohort
#2
Daniele Grioni, Fabio Pavan, Giulia Prunotto, Francesco Canonico, Carlo de Grandi, Attilio Rovelli
Despite a wide number of studies trying to define clinical, physiopathological, and neuroradiological features of posterior reversible encephalopathy syndrome (PRES), the true nature of symptoms is still not fully understood. We studied a standard cohort of 24 pediatric patients, affected by hemato-oncological diseases, with a neuroradiological diagnosis consistent with PRES identified from 2006 to 2013. Ten of them developed PRES after hematopoietic stem cell transplantation. We analyzed the sequence of clinical, radiological, and electrophysiological data...
April 2017: Neuropediatrics
https://www.readbyqxmd.com/read/28240370/the-clinical-and-phylogenetic-investigation-for-a-nosocomial-outbreak-of-respiratory-syncytial-virus-infection-in-an-adult-hemato-oncology-unit
#3
Daijiro Nabeya, Takeshi Kinjo, Gretchen Lynn Parrott, Ayako Uehara, Daisuke Motooka, Shota Nakamura, Saifun Nahar, Sawako Nakachi, Masashi Nakamatsu, Sakuko Maeshiro, Shusaku Haranaga, Masao Tateyama, Takeaki Tomoyose, Hiroaki Masuzaki, Toshihiro Horii, Jiro Fujita
Although many reports have already shown RSV outbreaks among hemato-oncology patients, genomic studies detecting similar RSV strains prior to an outbreak in the hospital are rare. In 2014, the University of the Ryukyus hospital hemato-oncology unit experienced, and successfully managed, a respiratory syncytial virus (RSV) nosocomial outbreak. During the outbreak investigation, genotyping and phylogenetic analysis was used to identify a potential source for the outbreak. Nasopharyngeal swabs were tested for RSV using three tests: (1) rapid antigen test (RAT); (2) reverse transcriptase polymerase chain reaction (PCR); or (3) quantitative PCR (RT-qPCR); a positive PCR reaction was considered a confirmed case of RSV...
February 27, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28190865/late-onset-neutropenia-after-rituximab-therapy-in-patients-with-autoimmune-thrombotic-and-hemostatic-disorders-a-single-center-analysis
#4
Yoshiyuki Ogawa, Kunio Yanagisawa, Takuma Ishizaki, Hiroaki Shimizu, Takeki Mitsui, Akitada Ichinose, Yoshihisa Nojima, Hiroshi Handa
Autoimmune thrombotic and hemostatic disorders, caused by autoantibodies against various factors regulating thrombosis and hemostasis, are rare. Rituximab (RTX) is on occasion used for treating these disorders. Late-onset neutropenia (LON) has been described as a side effect of RTX treatment for patients with hemato-oncological and/or rheumatological diseases but not for those with autoimmune thrombotic and hemostatic disorders. Eleven patients with autoimmune thrombotic and hemostatic disorders received RTX in our institution...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28161296/successful-treatment-of-talaromyces-amestolkiae-pulmonary-infection-with-voriconazole-in-an-acute-lymphoblastic-leukemia-patient
#5
Hiram Villanueva-Lozano, Rogelio de J Treviño-Rangel, Erick W Renpenning-Carrasco, Gloria M González
Infections due to Talaromyces spp. are uncommon, but they have been reported previously as causative agents of disease in immunocompromised patients. The prognosis of hemato-oncological patients with an invasive fungal infection is generally poor and the identification of the causative agent is usually not achieved or in some cases the isolated agent is taken as a contaminant and not treated, which contributes to their bad outcome. We report a case of Talaromyces amestolkiae pulmonary infection in an acute lymphoblastic leukemia patient, which was successfully treated with voriconazole, and discuss the importance of molecular identification and treatment of non-traditionally pathogenic fungi in this specific subset of patients...
February 1, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28056827/strain-specific-transmission-in-an-outbreak-of-esbl-producing-enterobacteriaceae-in-the-hemato-oncology-care-unit-a-cohort-study
#6
Makiko Uemura, Osamu Imataki, Shumpei Uchida, Haruyuki Nakayama-Imaohji, Yukiko Ohue, Harumi Matsuka, Hatsune Mori, Hiroaki Dobashi, Tomomi Kuwahara, Norimitsu Kadowaki
BACKGROUND: Extended-spectrum β-lactamase (ESBL)-producing bacteria are resistant to several types of antibiotics excluding carbapenems. A transmissibility of ESBL-producing Enterobacteriaceae would be depending on each bacterial property, however, that has not been elucidated in clinical setting. In this study, we attempted to identify the source of an outbreak of ESBL-producing bacteria in a medical oncology and immunology care unit. METHODS: An ESBL-producing Enterobacteriaceae (ESBL-E) outbreak observed between July 2012 and August 2012 in Kagawa University Hospital was surveyed using various molecular microbiology techniques...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28049251/validation-of-the-pediatric-index-of-mortality-3-in-a-single-pediatric-intensive-care-unit-in-korea
#7
Ok Jeong Lee, Minyoung Jung, Minji Kim, Hae Kyoung Yang, Joongbum Cho
To compare mortality rate, the adjustment of case-mix variables is needed. The Pediatric Index of Mortality (PIM) 3 score is a widely used case-mix adjustment system of a pediatric intensive care unit (ICU), but there has been no validation study of it in Korea. We aim to validate the PIM3 in a Korean pediatric ICU, and extend the validation of the score from those aged 0-16 to 0-18 years, as patients aged 16-18 years are admitted to pediatric ICU in Korea. A retrospective cohort study of 1,710 patients was conducted in a tertiary pediatric ICU...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28032062/impact-of-ego-resilience-and-family-function-on-quality-of-life-in-childhood-leukemia-survivors
#8
Ok-Hee Cho, Yang-Sook Yoo, Kyung-Hye Hwang
BACKGROUND: This study aimed to examine the impact of ego-resilience and family function on quality of life in childhood leukemia survivors. METHODS: This study targeted 100 pediatric leukemia survivors, who visited the Pediatric Hemato-Oncology Center in South Korea from Aug to Dec 2011. A structured questionnaire of ego-resilience, family function and quality of life used to collect data through direct interview with the pediatric patients and their parents. The correlation between the study variables analyzed using the Pearson's correlation coefficient, and the impact on quality of life analyzed using a stepwise multiple regression...
November 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28011902/ecil-6-guidelines-for-the-treatment-of-invasive-candidiasis-aspergillosis-and-mucormycosis-in-leukemia-and-hematopoietic-stem-cell-transplant-patients
#9
Frederic Tissot, Samir Agrawal, Livio Pagano, Georgios Petrikkos, Andreas H Groll, Anna Skiada, Cornelia Lass-Flörl, Thierry Calandra, Claudio Viscoli, Raoul Herbrecht
The European Conference on Infections in Leukemia (ECIL) provides recommendations for diagnostic strategies and prophylactic, pre-emptive or targeted therapy strategies for various types of infection in patients with hematologic malignancies or hematopoietic stem cell transplantation recipients. Meetings are held every two years since 2005 and evidence-based recommendations are elaborated after evaluation of the literature and discussion among specialists of nearly all European countries. In this manuscript, the ECIL group presents the 2015-update of the recommendations for the targeted treatment of invasive candidiasis, aspergillosis and mucormycosis...
March 2017: Haematologica
https://www.readbyqxmd.com/read/28004308/cutaneous-side-effects-and-transepidermal-water-loss-to-gefitinib-a-study-of-11-patients
#10
Franky Chandra, Dendi Sandiono, Unwati Sugiri, Oki Suwarsa, Hendra Gunawan
INTRODUCTION: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor. METHODS: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27983882/building-a-national-framework-for-adolescent-and-young-adult-hematology-and-oncology-and-transition-from-pediatric-to-adult-care-report-of-the-inaugural-meeting-of-the-ajet-working-group-of-the-german-society-for-pediatric-oncology-and-hematology
#11
Gabriele Escherich, Stefan Bielack, Stephan Maier, Ralf Braungart, Tim H Brümmendorf, Mathias Freund, Regine Grosse, Anette Hoferer, Rebecca Kampschulte, Barbara Koch, Melchior Lauten, Valeria Milani, Henning Ross, Freimut Schilling, Dieter Wöhrle, Holger Cario, Uta Dirksen
Adolescents and young adults (AYAs) with hemato-oncological problems constitute a heterogenous group with characteristic particularities, specific needs, and age-related clinical and unique psychosocial features. Strong collaboration between pediatric and adult hemato-oncology settings is essential to address their needs appropriately. This is not only true for patients who first become ill during adolescence or young adulthood, but equally so for people who contract hemato-oncological diseases congenitally or as younger children and who are now becoming old enough to leave the pediatric setting and have to transit into "adult" medical care...
December 16, 2016: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27941974/cost-evaluation-of-dried-blood-spot-home-sampling-as-compared-to-conventional-sampling-for-therapeutic-drug-monitoring-in-children
#12
Lisa C Martial, Rob E Aarnoutse, Michiel F Schreuder, Stefanie S Henriet, Roger J M Brüggemann, Manuela A Joore
Dried blood spot (DBS) sampling for the purpose of therapeutic drug monitoring can be an attractive alternative for conventional blood sampling, especially in children. This study aimed to compare all costs involved in conventional sampling versus DBS home sampling in two pediatric populations: renal transplant patients and hemato-oncology patients. Total costs were computed from a societal perspective by adding up healthcare cost, patient related costs and costs related to loss of productivity of the caregiver...
2016: PloS One
https://www.readbyqxmd.com/read/27924467/indian-pediatric-postgraduate-s-perspective-on-future-career-intentions
#13
Latha M Sneha, Manipriya Ravindran, Rekha Kumar, Padmasani Venkatraman, Julius Scott, LakshmiNarayan Kannan
OBJECTIVE: To determine the factors that influence Pediatric residents to pursue a subspecialty career and establish their choice of future workplace. METHODS: The present questionnaire based study was conducted during a National level pediatric post graduate exam refresher course in Chennai, India and involved Pediatric residents from all parts of India. Datas was analysed with the statistical package for social sciences (SPSS, version 18.0). RESULTS: Seventy five respondents participated in the study...
December 7, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27910012/chromosome-preparation-for-chronic-lymphoid-malignancies
#14
Dorota Koczkodaj, Agata A Filip
Conventional cytogenetics is invariably one of the most important methods used in diagnostics of chronic lymphoproliferations. It complements fluorescence in situ hybridization (FISH) and molecular analysis. Presence of particular chromosomal alterations in chronic lymphocytic leukemia enables patients' stratification into appropriate cytogenetic risk groups and influences treatment decisions. In other non-Hodgkin lymphomas cytogenetic analyses are employed also in minimal residual disease assessment.As lymphocytes in chronic lymphoid malignancies are characterized by low proliferation rate in vitro, it is critical to induce their division in the culture properly...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27908537/the-unusual-association-between-neuroblastoma-and-gaucher-disease-case-report-and-review-of-the-literature
#15
Annalisa Madeo, Alberto Garaventa, Angela Rita Sementa, Chiara Suffia, Maja Di Rocco
Gaucher disease (GD) patients have an increased risk of cancer, in particular of hematological origin, while the association between GD and Neuroblastoma (NBL) has never been described. Here we report the case of an adolescent diagnosed with NBL, also presenting splenomegaly and persistent thrombocytopenia. The association with GD, suggested by the histological findings on bone marrow biopsy, was confirmed by enzymatic and genetic tests. The possible pathogenetic mechanisms are briefly reviewed. The evidence of this new association supports the necessity of further studies on GD comorbidities and the need of systematic data collection and analysis, potentially through an international registry...
November 23, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27876058/a-novel-non-hodgkin-lymphoma-murine-model-closer-to-the-standard-clinical-scenario
#16
Thais Bascuas, María Moreno, Amy Mónaco, Laura Reyes, Andrea Paolino, Patricia Oliver, María G Kramer, Henry Engler, José P Pacheco, Sofía Grille, José A Chabalgoity
BACKGROUND: Non-Hodgkin lymphomas (NHL) are the most frequent hemato-oncological malignancies. Despite recent major advances in treatment, a substantial proportion of patients relapses highlighting the need for new therapeutic modalities. Promissory results obtained in pre-clinical studies are usually not translated when moving into clinical trials. Pre-clinical studies are mainly conducted in animals with high tumor burden; instead patients undergo chemotherapy as first line of treatment and most likely are under remission when immunotherapies are applied...
November 22, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27712712/which-questionnaire-should-be-used-to-measure-quality-of-life-utilities-in-patients-with-acute-leukemia-an-evaluation-of-the-validity-and-interpretability-of-the-eq-5d-5l-and-preference-based-questionnaires-derived-from-the-eortc-qlq-c30
#17
Annemieke van Dongen-Leunis, W Ken Redekop, Carin A Uyl-de Groot
OBJECTIVES: The aim of this study was to assess the validity and interpretability of different preference-based questionnaires (generic 5-level EuroQol five-dimensional questionnaire [EQ-5D-5L], cancer-specific Quality of Life Questionnaire Preference-Based Measure, and European Organization of Randomized Controlled Trials 8 Dimension [EORTC-8D]) in patients with acute leukemia. METHODS: Patients who participated in Hemato-Oncologie voor Volwassenen Nederland (HOVON - the Haemato Oncology Foundation for Adults in the Netherlands) clinical trials between 1999 and 2011 at a single hospital were invited to complete the questionnaires...
September 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27704258/radial-ultrasound-assisted-transbronchial-biopsy-a-new-diagnostic-approach-for-non-resolving-pulmonary-infiltrates-in-neutropenic-hemato-oncological-patients
#18
Maurizio Bernasconi, Alessio Casutt, Angela Koutsokera, Igor Letovanec, Frédéric Tissot, Laurent P Nicod, Alban Lovis
The role of radial-endobronchial ultrasound (R-EBUS) assisted transbronchial biopsy (TBB) for the diagnosis of peripheral pulmonary lesions is well established. However, no study has addressed its safety and value in hemato-oncological patients presenting with non-resolving infiltrates during persistent febrile neutropenia. To assess safety and feasibility of R-EBUS assisted TBB in severe thrombocytopenic and neutropenic patients. Over a period of 18 months, eight patients were assessed with R-EBUS assisted TBB after adequate platelet transfusion...
October 4, 2016: Lung
https://www.readbyqxmd.com/read/27690629/optimizing-antifungal-strategies-to-improve-patient-survival
#19
Paul Verweij, Sue Lyon
Report from the 26th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2016), 9-12 April Amsterdam, The Netherlands Invasive fungal infections are a major threat to the lives of the increasing number of immunocompromized patients, but neutropenic hemato-oncology patients are at especially high risk. Since effective antifungal treatment and prophylaxis are critical to improve survival in these patients, the emergence of antifungal drug resistance has become an increasing cause of concern...
October 3, 2016: Future Microbiology
https://www.readbyqxmd.com/read/27683100/the-treatment-of-childhood-acute-lymphoblastic-leukemia-in-guatemala-biologic-features-treatment-hurdles-and-results
#20
Federico G Antillón, Jessica G Blanco, Patricia D Valverde, Mauricio Castellanos, Claudia P Garrido, Veronica Girón, Tomas R Letona, Emilia J Osorio, Dyna A Borrayo, Ricardo A Mack, Mario A Melgar, Rodolfo Lorenzana, Raul C Ribeiro, Monika Metzger, Valentino Conter, Emanuela Rossi, Maria Grazia Valsecchi
BACKGROUND: The National Pediatric Oncology Unit (UNOP) is the only pediatric hemato-oncology center in Guatemala. METHODS: Patients ages 1 to 17 years with acute lymphoblastic leukemia (ALL) were treated according to modified ALL Intercontinental Berlin-Frankfurt-Münster (IC-BFM) 2002 protocol. Risk classification was based on age, white blood cell count, immunophenotype, genetics (when available), and early response to therapy. RESULTS: From July 2007 to June 2014, 787 patients were treated, including 160 who had standard-risk ALL, 450 who had intermediate-risk ALL, and 177 who had high-risk ALL...
September 28, 2016: Cancer
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