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Epilepsy vns

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https://www.readbyqxmd.com/read/28070485/vagus-nerve-stimulation-for-genetic-epilepsy-with-febrile-seizures-plus-gefs-accompanying-seizures-with-impaired-consciousness
#1
Ryosuke Hanaya, Fajar H Niantiarno, Yumi Kashida, Hiroshi Hosoyama, Shinsuke Maruyama, Toshiaki Otsubo, Kazumi Tanaka, Atsushi Ishii, Shinichi Hirose, Kazunori Arita
Genetic epilepsy with febrile seizures plus (GEFS(+)) is characterized by childhood-onset epilepsy syndrome. It involves febrile seizures and a variety of afebrile epileptic seizure types within the same pedigree with autosomal-dominant inheritance. Approximately 10% of individuals with GEFS(+) harbor SCN1A, a gene mutation in one of the voltage-gated sodium channel subunits. Considerably less common are focal epilepsies including complex partial seizures. We report vagus nerve stimulation (VNS) in a 6-year-old girl with GEFS(+) who exhibited refractory generalized tonic-clonic seizures and complex partial seizures...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/27992003/neuromodulation-in-refractory-epilepsy-brazilian-specialists-consensus
#2
Vera Cristina Terra, Isabella D'Andrea-Meira, Ricardo Amorim, Francisco Arruda, Andrea Julião de Oliveira, Luciano De Paola, Adélia Maria de Miranda Henriques-Souza
Epilepsy is a potentially devastating brain disorder characterized by a predisposition to spontaneous epileptic seizures. In patients with medically refractory epilepsy, new non-pharmacological therapeutic approaches may be considered. In this scenario, palliative surgery such as vagus nerve stimulation (VNS) or deep brain stimulation (DBS) may be indicated in a subset of patients. In this paper we make recommendations for the use of VNS and DBS in patients in Brazil with refractory epilepsy.
December 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27988257/parametric-characterization-of-neural-activity-in-the-locus-coeruleus-in-response-to-vagus-nerve-stimulation
#3
Daniel R Hulsey, Jonathan R Riley, Kristofer W Loerwald, Robert L Rennaker, Michael P Kilgard, Seth A Hays
Vagus nerve stimulation (VNS) has emerged as a therapy to treat a wide range of neurological disorders, including epilepsy, depression, stroke, and tinnitus. Activation of neurons in the locus coeruleus (LC) is believed to mediate many of the effects of VNS in the central nervous system. Despite the importance of the LC, there is a dearth of direct evidence characterizing neural activity in response to VNS. A detailed understanding of the brain activity evoked by VNS across a range of stimulation parameters may guide selection of stimulation regimens for therapeutic use...
December 14, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27974275/quality-of-life-metrics-with-vagus-nerve-stimulation-for-epilepsy-from-provider-survey-data
#4
Dario J Englot, Kevin H Hassnain, John D Rolston, Stephen C Harward, Saurabh R Sinha, Michael M Haglund
OBJECTIVE: Drug-resistant epilepsy is a devastating disorder associated with diminished quality of life (QOL). Surgical resection leads to seizure freedom and improved QOL in many epilepsy patients, but not all individuals are candidates for resection. In these cases, neuromodulation-based therapies such as vagus nerve stimulation (VNS) are often used, but most VNS studies focus exclusively on reduction of seizure frequency. QOL changes and predictors with VNS remain poorly understood...
December 11, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27973753/vagal-nerve-stimulation-modifies-neuronal-activity-and-the-proteome-of-excitatory-synapses-of-amygdala-piriform-cortex
#5
Georgia M Alexander, Yang Zhong Huang, Erik J Soderblom, Xiao-Ping He, Arthur M Moseley, James O McNamara
Vagal Nerve Stimulation (VNS) Therapy(®) is a United States Food and Drug Administration (FDA) approved neurotherapeutic for medically refractory partial epilepsy and treatment-resistant depression. The molecular mechanisms underlying its beneficial effects are unclear. We hypothesized that one mechanism involves neuronal activity-dependent modifications of central nervous system excitatory synapses. To begin to test this hypothesis, we asked whether VNS modifies the activity of neurons in amygdala and hippocampus...
December 14, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27919011/cardiovascular-autonomic-and-hemodynamic-responses-to-vagus-nerve-stimulation-in-drug-resistant-epilepsy
#6
Iñigo Garamendi, Marian Acera, Marta Agundez, Lara Galbarriatu, Ainhoa Marinas, Iñigo Pomposo, Elena Valle, Jose-Alberto Palma, Juan C Gomez-Esteban
PURPOSE: Vagus nerve stimulation (VNS) is used as an adjunctive therapy for treating patients with drug-resistant epilepsy. The impact of VNS on cardiovascular autonomic function remains to be fully understood. We determined changes in cardiovascular sympathetic and parasympathetic, and hemodynamic function in association with VNS in patients with drug-resistant focal epilepsy. METHOD: Longitudinal (n=15) evaluation of beat-to-beat blood pressure (BP) and heart rate variability (HRV), baroreflex sensibility, and hemodynamic function performed before VNS implantation, 6-months after implantation, and a mean of 12-months after implantation; and cross-sectional study (n=14) of BP and HR variability and baroreflex sensitivity during VNS on and VNS off...
December 2, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27898202/optimization-of-transcutaneous-vagus-nerve-stimulation-using-functional-mri
#7
Natalia Yakunina, Sam Soo Kim, Eui-Cheol Nam
OBJECTIVE/HYPOTHESIS: Vagus nerve stimulation (VNS) is an established therapy for drug-resistant epilepsy, depression, and a number of other disorders. Transcutaneous stimulation of the auricular branch of the vagus nerve (tVNS) has been considered as a non-invasive alternative. Several functional magnetic resonance imaging (fMRI) studies on the effects of tVNS used different stimulation parameters and locations in the ear, which makes it difficult to determine the optimal tVNS methodology...
November 29, 2016: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/27878616/effectiveness-of-vagal-nerve-stimulation-in-medication-resistant-epilepsy-comparison-between-patients-with-and-without-medication-changes
#8
María A García-Pallero, Eduardo García-Navarrete, Cristina V Torres, Jesús Pastor, Marta Navas, R G Sola
BACKGROUND: Vagal nerve stimulation (VNS) response is not immediate. A progressive decline in seizure frequency is usually found during a period of 12-18 months after implantation. During this time, the patient's medication is usually modified, which can create doubts about whether their clinical improvement is due to medication changes or to VNS itself. Our goal is to compare two groups of patients treated with VNS, with and without changes in their medication. METHODS: We prospectively analyze 85 patients who were treated with VNS in our hospital between 2005 and 2014...
January 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27823948/amelioration-of-intractable-epilepsy-by-adjunct-vagus-nerve-stimulation-therapy-in-a-girl-with-a-cdkl5-mutation
#9
Shimpei Baba, Yuji Sugawara, Kengo Moriyama, Motoki Inaji, Taketoshi Maehara, Toshiyuki Yamamoto, Tomohiro Morio
We report the case of on an 8-year-old girl with a cyclin-dependent kinase-like 5 mutation and who underwent vagus nerve stimulation (VNS) therapy for 2years. She had developed epilepsy at the age of 6months and had severe developmental delays. Initially, she had tonic and tonic-clonic seizures; however, around the age of 5years, she also developed epileptic spasms. These seizures were never completely controlled by conventional medical treatments. At the age of 7, after VNS initiation, her seizure frequency markedly reduced, and abnormal electrical activities on her electroencephalography tests strikingly decreased...
November 4, 2016: Brain & Development
https://www.readbyqxmd.com/read/27785033/vagus-nerve-stimulation-balanced-disrupted-default-mode-network-and-salience-network-in-a-postsurgical-epileptic-patient
#10
Kailiang Wang, Qi Chai, Hui Qiao, Jianguo Zhang, Tinghong Liu, Fangang Meng
INTRODUCTION: In recent years, treatment of intractable epilepsy has become more challenging, due to an increase in resistance to antiepileptic drugs, as well as diminished success following resection surgery. Here, we present the case of a 19-year old epileptic patient who received vagus nerve stimulation (VNS) following unsuccessful left parietal-occipital lesion-resection surgery, with results indicating an approximate 50% reduction in seizure frequency and a much longer seizure-free interictal phase...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27743550/the-effect-of-vagus-nerve-stimulation-on-response-inhibition
#11
Hanne Schevernels, Marlies E van Bochove, Leen De Taeye, Klaas Bombeke, Kristl Vonck, Dirk Van Roost, Veerle De Herdt, Patrick Santens, Robrecht Raedt, C Nico Boehler
In the current study, we explored whether vagus nerve stimulation (VNS) in patients with epilepsy, which is believed to increase norepinephrine (NE) levels via activation of the locus coeruleus, would positively affect response inhibition. Moreover, we tried to identify the dynamics of the underlying neural processes by investigating event-related potentials (ERPs) and pupil size. Patients performed a stop-signal task once when stimulation was switched on and once when it was switched off. We found a correlational pattern suggesting that patients who clinically benefit more from VNS treatment also show a larger behavioral advantage, in terms of faster response inhibition, when the vagus nerve is being stimulated...
October 12, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27738822/the-role-of-laryngeal-electromyography-in-vagus-nerve-stimulation-related-vocal-fold-dysmotility
#12
Alberto M Saibene, Elena Zambrelli, Carlotta Pipolo, Alberto Maccari, Giovanni Felisati, Elena Felisati, Francesca Furia, Aglaia Vignoli, Maria Paola Canevini, Enrico Alfonsi
Vagus nerve stimulation (VNS) is a useful tool for drug-resistant epilepsy, but it induces known laryngeal side effects, with a significant role on patients' quality of life. VNS patients may show persistent left vocal fold (LVF) palsy at rest and/or recurrent LVF adduction during stimulation. This study aims at electromyographically evaluating laryngeal muscles abnormalities in VNS patients. We compared endoscopic laryngeal evaluation data in six VNS patients with laryngeal muscle electromyography (LMEMG) carried out on the thyroarytenoid, cricothyroid, posterior cricoarytenoid, and cricopharyngeal muscles...
October 13, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27723668/vagus-nerve-stimulation-an-evolving-adjunctive-treatment-for-cardiac-disease
#13
Barış Akdemir, David G Benditt
The vagus nerve is a major component of the autonomic nervous system and plays a critical role in many body functions including for example, speech, swallowing, heart rate and respiratory control, gastric secretion, and intestinal motility. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve, with electrical stimulation being the most important. Implantable devices for VNS are approved therapy for refractory epilepsy and for treatment-resistant depression. In the case of heart disease applications, implantable VNS has been shown to be beneficial for treating heart failure in both preclinical and clinical studies...
October 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27714458/an-interictal-eeg-can-predict-the-outcome-of-vagus-nerve-stimulation-therapy-for-children-with-intractable-epilepsy
#14
Min-Jee Kim, Mi-Sun Yum, Eun-Hee Kim, Yun-Jeong Lee, Junkyo Lee, Seokho Hong, Su Jeong You, Yong Soon Hwang, Tae-Sung Ko
PURPOSE: This study aimed to evaluate the long-term efficacy of vagus nerve stimulation (VNS) in children and adolescents with intractable epilepsy and identify predictive factors for responsiveness to VNS. METHODS: Medical records of pediatric patients who underwent VNS implantation at two Korean tertiary centers were reviewed. At 0.5, 1, 3, and 5 years post-VNS implantation, the frequency of the most disabling seizures in each patient was assessed. Responders were defined as showing an overall 50 % reduction from baseline seizure frequency during follow-up...
October 6, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27712133/eeg-derived-brain-activity-reflects-treatment-response-from-vagus-nerve-stimulation-in-patients-with-epilepsy
#15
Simon Wostyn, Willeke Staljanssens, Leen De Taeye, Gregor Strobbe, Stefanie Gadeyne, Dirk Van Roost, Robrecht Raedt, Kristl Vonck, Pieter van Mierlo
The mechanism of action of vagus nerve stimulation (VNS) is yet to be elucidated. To that end, the effects of VNS on the brain of epileptic patients were studied. Both when VNS was switched "On" and "Off", the brain activity of responders (R, seizure frequency reduction of over 50%) was compared to the brain activity of nonresponders (NR, seizure frequency reduction of less than 50%). Using EEG recordings, a significant increase in P300 amplitude for R and a significant decrease in P300 amplitude for NR were found...
July 11, 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/27690293/socioeconomic-evaluation-of-vagus-stimulation-a-controlled-national-study
#16
Poul Jennum, Anne Sabers, Jakob Christensen, Rikke Ibsen, Jakob Kjellberg
PURPOSE: We aimed to determine the health costs and social outcomes in terms of education, employment and income level after insertion of a vagus nerve stimulator (VNS) in patients with epilepsy. METHODS: This is a case-control study using Danish health care and socioeconomic register data. The analysis of the effect involved a comparison of the health care costs, occupation and income status of VNS-treated epilepsy patients with those of a control group of epilepsy patients who had a VNS implanted during the 12 months before the index date (pre-period) and during the two years after the index date (post-period)...
November 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27591681/cost-utility-analysis-of-competing-treatment-strategies-for-drug-resistant-epilepsy-in-children-with-tuberous-sclerosis-complex
#17
Aria Fallah, Alexander G Weil, Shelly Wang, Evan Lewis, Christine B Baca, Gary W Mathern
BACKGROUND: The management of drug-resistant epilepsy in children with Tuberous Sclerosis Complex (TSC) is challenging because of the multitude of treatment options, wide range of associated costs, and uncertainty of seizure outcomes. The most cost-effective approach for children whose epilepsy has failed to improve with first-line medical therapy is uncertain. METHODS: A review of MEDLINE from 1990 to 2015 was conducted. A cost-utility analysis, from a third-party payer perspective, was performed for children with drug-resistant epilepsy that had failed to improve with 2 antiseizure drugs (ASDs) and that was amenable to resective epilepsy surgery, across a time-horizon of 5years...
October 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27516384/comparing-neurostimulation-technologies-in-refractory-focal-onset-epilepsy
#18
REVIEW
Inuka Kishara Gooneratne, Alexander L Green, Patricia Dugan, Arjune Sen, Angelo Franzini, Tipu Aziz, Binith Cheeran
For patients with pharmacoresistant focal epilepsy in whom surgical resection of the epileptogenic focus fails or was not feasible in the first place, there were few therapeutic options. Increasingly, neurostimulation provides an alternative treatment strategy for these patients. Vagal nerve stimulation (VNS) is well established. Deep brain stimulation (DBS) and cortical responsive stimulation (CRS) are newer neurostimulation therapies with recently published long-term efficacy and safety data. In this literature review, we introduce these therapies to a non-specialist audience...
November 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27497814/how-does-vagal-nerve-stimulation-vns-change-eeg-brain-functional-connectivity
#19
Fabrice Bartolomei, Francesca Bonini, Elsa Vidal, Agnes Trébuchon, Stanislas Lagarde, Isabelle Lambert, Aileen McGonigal, Didier Scavarda, Romain Carron, Christian G Benar
An effect of vagal nerve stimulation (VNS) on cortical synchronization has been postulated but remains to be verified. In this study we investigated the impact of VNS on functional connectivity (Fc) using direct intracerebral recordings (stereotactic EEG, SEEG). Five patients with epilepsy who underwent SEEG recordings during ongoing VNS therapy were investigated. Interdependencies between twenty-six selected bipolar SEEG channels were estimated by nonlinear regression analysis during ON and OF periods of stimulation...
October 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27484491/investigation-of-mechanisms-of-vagus-nerve-stimulation-for-seizure-using-finite-element-modeling
#20
Jeffrey E Arle, Kristen W Carlson, Longzhi Mei
OBJECTIVE: While the efficacy of vagus nerve stimulation (VNS) to reduce seizures in pharmaco-resistant patients is clinically proven, its efficacy and side effects mechanisms are not fully understood. Our goals were 1) to use a finite element model (FEM) and axon models to examine different fiber activation and blocking thresholds and 2) examine fiber activation and blocking in three fiber groups likely to be responsible for efficacy and side effects. METHODS: Using FEM, we examined the field potential along axons within a vagus nerve model with fascicles...
October 2016: Epilepsy Research
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