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Epilepsy vns

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https://www.readbyqxmd.com/read/29905938/evolution-over-time-of-sudep-incidence-a-nationwide-population-based-cohort-study
#1
Torbjörn Tomson, Olafur Sveinsson, Sofia Carlsson, Tomas Andersson
Prompted by a recent report on declining incidence of sudden unexpected death in epilepsy (SUDEP) following implantation of a vagus nerve stimulator (VNS), we analyzed SUDEP risk over 6 years in a population-based cohort of 60 952 epilepsy patients in Sweden. All deaths from July 1, 2006 through December 31, 2011, were identified. Those with epilepsy mentioned on the death certificate were adjudicated for SUDEP using medical records and autopsy reports. In all, 292 SUDEP cases were identified. Comparing the first years (2006-2007) with the subsequent 4 years (2008-2011), the crude and standardized (to the US 2000 population) incidence of SUDEP (whether or not possible SUDEP was included) was significantly lower during the second time period; Incidence rate ratios based on standardized rates was estimated at 0...
June 15, 2018: Epilepsia
https://www.readbyqxmd.com/read/29844694/a-review-of-vagus-nerve-stimulation-as-a-therapeutic-intervention
#2
REVIEW
Rhaya L Johnson, Christopher G Wilson
In this review, we provide an overview of the US Food and Drug Administration (FDA)-approved clinical uses of vagus nerve stimulation (VNS) as well as information about the ongoing studies and preclinical research to expand the use of VNS to additional applications. VNS is currently FDA approved for therapeutic use in patients aged >12 years with drug-resistant epilepsy and depression. Recent studies of VNS in in vivo systems have shown that it has anti-inflammatory properties which has led to more preclinical research aimed at expanding VNS treatment across a wider range of inflammatory disorders...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29789596/cervical-vagus-nerve-morphometry-and-vascularity-in-the-context-of-nerve-stimulation-a-cadaveric-study
#3
Niels Hammer, Sabine Löffler, Yusuf Ozgur Cakmak, Benjamin Ondruschka, Uwe Planitzer, Michael Schultz, Dirk Winkler, David Weise
Vagus nerve stimulation (VNS) has become a well-established therapy for epilepsy and depression, and is emerging to treat inflammatory disease, with the cervical vagus nerve (CVN) as major stimulation site. CVN morphometries are missing for VNS, considering its variability. Morphometric data were obtained from CVNs in 27 cadavers, including branching patterns and histology. Cross-sectional area, greater and lesser diameters averaged 7.2 ± 3.1 mm2 , 5.1 ± 1.5 and 4.1 ± 1.3 mm, and were ≤11...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29786802/-treatment-with-neurostimulation-and-ketogenic-diet-for-people-with-medically-refractory-epilepsy
#4
Eva Kumlien, Tove Hallbook, Maria Dahlin
For some people with medically refractory epilepsy adjunct treatment with neurostimulation and ketogenic diet can be an option. Vagal nerve stimulation, VNS, consists of chronic intermittent electrical stimulation of the vagus nerve. VNS is effective and well tolerated in adolescents and adults. There is insufficient evidence on the efficacy of deep brain stimulation, DBS, and brain-responsive neurostimulation, RNS. Ketogenic diet is an established treatment in epilepsy with an increased number of indications, especially in neurometabolic diseases, where dietary therapy can completely eliminate epilepsy and improve cognitive and motor development...
May 22, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29740975/similarities-between-the-responses-to-ant-dbs-and-prior-vns-in-refractory-epilepsy
#5
Toni Kulju, Joonas Haapasalo, Kai Lehtimäki, Sirpa Rainesalo, Jukka Peltola
OBJECTIVES: Neurostimulation has offered new treatment options in refractory epilepsy, first with vagus nerve stimulation (VNS) and more recently with deep brain stimulation (DBS). There is a lack of previous detailed data assessing the relationship between VNS and ANT-DBS. The aim of this study was to investigate the potential correlation between therapeutic responses to VNS and ANT-DBS. MATERIALS AND METHODS: A total of 11 patients with previous VNS therapy underwent ANT-DBS implantation...
May 8, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29738985/single-center-long-term-results-of-vagus-nerve-stimulation-for-epilepsy-a-10-17-year-follow-up-study
#6
Jan Chrastina, Zdeněk Novák, Tomáš Zeman, Jitka Kočvarová, Martin Pail, Irena Doležalová, Jiří Jarkovský, Milan Brázdil
PURPOSE: The paper presents a long-term follow-up study of VNS patients, analyzing seizure outcome, medication changes, and surgical problems. METHOD: 74 adults with VNS for 10 to 17 years were evaluated yearly as: non-responder - NR (seizure frequency reduction <50%), responder - R (reduction ≥ 50% and <90%), and 90% responder - 90R (reduction ≥ 90%). Delayed R or 90R (≥ 4 years after surgery), patients with antiepileptic medication changes and battery or complete system replacement were identified...
April 30, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29709876/chronic-vagus-nerve-stimulation-reverses-heart-rhythm-complexity-in-patients-with-drug-resistant-epilepsy-an-assessment-with-multiscale-entropy-analysis
#7
Hongyun Liu, Zhao Yang, Fangang Meng, Lei Huang, Wei Qu, Hongwei Hao, Jianguo Zhang, Luming Li
OBJECTIVE: Vagus nerve stimulation (VNS) is an adjunctive treatment in drug-resistant epilepsy. The alterations in heart rate dynamics through VNS are not well understood. This study aimed to determine changes in heart rhythm complexity in association with VNS and to relate the findings to the outcome of VNS treatment in patients with drug-resistant epilepsy. METHODS: We prospectively analyzed 32 patients with drug-resistant epilepsy, who underwent VNS implantation, and 32 age- and sex-matched healthy control subjects...
June 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29702412/vagus-nerve-stimulation-for-6-to-12-year-old-children-with-refractory-epilepsy-impact-on-seizure-frequency-and-parenting-stress-index
#8
Hueng-Chuen Fan, Ting-Rong Hsu, Kai-Ping Chang, Shyi-Jou Chen, Jeng-Dau Tsai
OBJECTIVES: Refractory epilepsy (RE) is frequently associated with neuropsychological impairment in children and may disrupt their social development. Vagus nerve stimulation (VNS) had been reported to have beneficial effects on behavioral outcomes. The aim of this study was to compare Parenting Stress Index (PSI) scores before and after VNS device implantation in children with RE, especially those who experienced seizure frequency reduction. METHODS: We conducted a one-group pretest-posttest study in school age children with RE...
April 24, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29702409/clinical-outcomes-of-vns-therapy-with-aspiresr-%C3%A2-including-cardiac-based-seizure-detection-at-a-large-complex-epilepsy-and-surgery-centre
#9
Preci Hamilton, Imad Soryal, Prince Dhahri, Welege Wimalachandra, Anna Leat, Denise Hughes, Nicole Toghill, James Hodson, Vijay Sawlani, Tom Hayton, Shanika Samarasekera, Manny Bagary, Dougall McCorry, Ramesh Chelvarajah
PURPOSE: To compare the efficacy of AspireSR® to preceding VNS battery models for battery replacements, and to determine the efficacy of the AspireSR® for new implants. METHODS: Data were collected retrospectively from patients with epilepsy who had VNS AspireSR® implanted over a three-year period between June 2014 and June 2017 by a single surgeon. Cases were divided into two cohorts, those in whom the VNS was a new insertion, and those in whom the VNS battery was changed from a previous model to AspireSR® ...
March 28, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29675810/neurostimulation-for-memory-enhancement-in-epilepsy
#10
REVIEW
Stephen Meisenhelter, Barbara C Jobst
PURPOSE OF REVIEW: Memory is one of the top concerns of epilepsy patients, but there are no known treatments to directly alleviate the memory deficits associated with epilepsy. Neurostimulation may provide new therapeutic tools to enhance memory in epilepsy patients. Here, we critically review recent investigations of memory enhancement using transcranial electrical stimulation (tES), transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), chronic intracranial stimulation, and acute intracranial stimulation...
April 19, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29670050/epilepsy-and-neuromodulation-randomized-controlled-trials
#11
Churl-Su Kwon, Valeria Ripa, Omar Al-Awar, Fedor Panov, Saadi Ghatan, Nathalie Jetté
Neuromodulation is a treatment strategy that is increasingly being utilized in those suffering from drug-resistant epilepsy who are not appropriate for resective surgery. The number of double-blinded RCTs demonstrating the efficacy of neurostimulation in persons with epilepsy is increasing. Although reductions in seizure frequency is common in these trials, obtaining seizure freedom is rare. Invasive neuromodulation procedures (DBS, VNS, and RNS) have been approved as therapeutic measures. However, further investigations are necessary to delineate effective targeting, minimize side effects that are related to chronic implantation and to improve the cost effectiveness of these devices...
April 18, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29651891/use-of-vagus-nerve-stimulator-on-children-with-primary-generalized-epilepsy
#12
William P Welch, Bilal Sitwat, Yoshimi Sogawa
OBJECTIVE: To describe the response to vagus nerve stimulator (VNS) in otherwise neurotypical children with medically intractable primary generalized epilepsy. METHODS: Retrospective chart review of patients who underwent vagus nerve stimulator surgery between January 2011 and December 2015. RESULTS: Eleven patients were identified. Median follow-up duration was 2.5 years (1.2-8.4 years). Prior to vagus nerve stimulator surgery, all patients had at least 1 seizure per week, and 7/11 (64%) had daily seizures...
June 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29608227/estimating-long-term-vagus-nerve-stimulation-effectiveness-accounting-for-antiepileptic-drug-treatment-changes
#13
David Révész, Victoria Fröjd, Bertil Rydenhag, Elinor Ben-Menachem
OBJECTIVE: To investigate the effectiveness of vagus nerve stimulation (VNS) in combination with pharmacological therapy in a longitudinal retrospective study at a single center. MATERIALS AND METHODS: Data from 130 consecutive patients implanted with a VNS device between the years 2000 and 2013 was analyzed. Seizure frequency and pharmacological antiepileptic drug (AED) treatments were recorded prior to as well as at one, two, and five years after VNS implantation...
April 2, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29590213/stochastic-vagus-nerve-stimulation-affects-acute-heart-rate-dynamics-in-rats
#14
Steven W Lee, Kanchan Kulkarni, Elizabeth M Annoni, Imad Libbus, Bruce H KenKnight, Elena G Tolkacheva
Vagus nerve stimulation (VNS) is an approved therapy for treatment of epilepsy and depression. While also shown to be promising in several preclinical and clinical studies to treat cardiovascular diseases, optimal therapeutic stimulation paradigms are still under investigation. Traditionally, parameters such as frequency, current, and duty cycle are used to adjust the efficacy of VNS therapy. This study explored the effect of novel stochastic VNS (S-VNS) on acute heart rate (HR) dynamics. The effect of S-VNS was evaluated in Sprague Dawley rats by comparing the acute HR and HR variability (HRV) responses to standard, periodic VNS (P-VNS) across different frequencies (FREQs, 10-30 Hz)...
2018: PloS One
https://www.readbyqxmd.com/read/29588984/effect-of-neurostimulation-on-cognition-and-mood-in-refractory-epilepsy
#15
REVIEW
Alvin Y Chan, John D Rolston, Vikram R Rao, Edward F Chang
Epilepsy is a common, debilitating neurological disorder characterized by recurrent seizures. Mood disorders and cognitive deficits are common comorbidities in epilepsy that, like seizures, profoundly influence quality of life and can be difficult to treat. For patients with refractory epilepsy who are not candidates for resection, neurostimulation, the electrical modulation of epileptogenic brain tissue, is an emerging treatment alternative. Several forms of neurostimulation are currently available, and therapy selection hinges on relative efficacy for seizure control and amelioration of neuropsychiatric comorbidities...
March 2018: Epilepsia Open
https://www.readbyqxmd.com/read/29555606/vagal-nerve-stimulator-malfunction-with-change-in-neck-position-case-report-and-literature-review
#16
Erin D'Agostino, Vyacheslav Makler, David F Bauer
BACKGROUND: Vagal nerve stimulation is a safe and well-tolerated treatment for drug-resistant epilepsy. Complications and failure of the device can result from lead fracture, device malfunction, disconnection, or battery displacement and can result in a variety of symptoms. We present an interesting case of stimulator malfunction with increased impedance change seen only with a change in head position. CASE DESCRIPTION: The patient is a 25-year-old male with a vagal nerve stimulator (VNs) placed for medically refractory epilepsy who presented with neck pain and an electrical pulling sensation in his neck whenever he turned his head to the right...
June 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29497072/preoperative-heart-rate-variability-as-predictors-of-vagus-nerve-stimulation-outcome-in-patients-with-drug-resistant-epilepsy
#17
Hong-Yun Liu, Zhao Yang, Fan-Gang Meng, Yu-Guang Guan, Yan-Shan Ma, Shu-Li Liang, Jiu-Luan Lin, Long-Sheng Pan, Ming-Ming Zhao, Wei Qu, Hong-Wei Hao, Guo-Ming Luan, Jian-Guo Zhang, Lu-Ming Li
Vagus nerve stimulation (VNS) is an adjunctive treatment for drug-resistant epilepsy (DRE). However, it is still difficult to predict which patients will respond to VNS treatment and to what extent. We aim to explore the relationship between preoperative heart rate variability (HRV) and VNS outcome. 50 healthy control subjects and 63 DRE patients who had received VNS implants and had at least one year of follow up were included. The preoperative HRV were analyzed by traditional linear methods and heart rhythm complexity analyses with multiscale entropy (MSE)...
March 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29493559/neurostimulation-for-drug-resistant-epilepsy-a-systematic-review-of-clinical-evidence-for-efficacy-safety-contraindications-and-predictors-for-response
#18
Paul Boon, Elien De Cock, Ann Mertens, Eugen Trinka
PURPOSE OF REVIEW: Neurostimulation is becoming an increasingly accepted treatment alternative for patients with drug-resistant epilepsy (DRE) who are unsuitable surgery candidates. Standardized guidelines on when or how to use the various neurostimulation modalities are lacking. We conducted a systematic review on the currently available neurostimulation modalities primarily with regard to effectiveness and safety. RECENT FINDINGS: For vagus nerve stimulation (VNS), there is moderate-quality evidence for its effectiveness in adults with drug-resistant partial epilepsies...
April 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29462779/effects-of-vagus-nerve-stimulation-on-heart-rate-variability-in-children-with-epilepsy
#19
Tugba Hirfanoglu, Ayse Serdaroglu, Ilker Cetin, Gokhan Kurt, Irem Y Capraz, Filiz Ekici, Ebru Arhan, Erhan Bilir
PURPOSE: The aim of this study was to evaluate the effects of vagus nerve stimulation (VNS) on heart rate variability (HRV) in children with epilepsy. METHODS: The subgroups of HRV, namely time domain (Standard deviation of NN interval (SDNN), SDNN index, Standard deviation of the averages of NN intervals (SDANN), Root mean square of successive differences (RMMSD), Adjacent NN intervals differing by more than 50 ms in the entire recording divided by the total number of all NN intervals (PNN50), triangular index) and frequency domain (Low-frequency (LF), High-frequency (HF), LF/HF), were investigated in 20 pediatric patients before and after 6 and 12months of VNS treatment during day and night by comparing their data with those of 20 control subjects...
April 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29425906/effects-of-vagal-neuromodulation-on-feeding-behavior
#20
REVIEW
Nicole A Pelot, Warren M Grill
Implanted vagus nerve stimulation (VNS) for obesity was recently approved by the FDA. However, its efficacy and mechanisms of action remain unclear. Herein, we synthesize clinical and preclinical effects of VNS on feeding behavior and energy balance and discuss engineering considerations for understanding and improving the therapy. Clinical cervical VNS (≤30 Hz) to treat epilepsy or depression has produced mixed effects on weight loss as a side effect, albeit in uncontrolled, retrospective studies. Conversely, preclinical studies (cervical and subdiaphragmatic VNS) mostly report decreased food intake and either decreased weight gain or weight loss...
February 7, 2018: Brain Research
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