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Correctional psychiatry

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https://www.readbyqxmd.com/read/28718394/multiple-possible-inaccuracies-cast-doubt-on-a-recent-report-suggesting-selective-serotonin-reuptake-inhibitors-to-be-toxic-and-ineffective
#1
Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksson
According to a systematic review on the use of selective serotonin reuptake inhibitors (SSRIs) in adult depression that was recently published in BMC Psychiatry, the results of which have been widely disseminated in lay media, these drugs increase the risk for serious adverse events (SAEs) while exerting poor antidepressant efficacy. A cursory analysis, however, suggests the analysis of SAEs conducted by the authors to be marred by both methodological inaccuracies and blatant errors. After having corrected for these apparent mistakes, we conducted a sensitivity analysis in which we also accounted for a possible moderating effect of age; while this suggests SSRIs to be safe drugs in the non-elderly, they do confirm what is already known, that is, that they may enhance the risk for SAEs in the old...
July 18, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28643573/correction-to-editorial-siegfried-kasper-international-journal-of-psychiatry-in-clinical-practice-2017-vol-21-no-2-p81
#2
(no author information available yet)
No abstract text is available yet for this article.
June 23, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28630456/rare-disruptive-variants-in-the-disc1-interactome-and-regulome-association-with-cognitive-ability-and-schizophrenia
#3
S Teng, P A Thomson, S McCarthy, M Kramer, S Muller, J Lihm, S Morris, D C Soares, W Hennah, S Harris, L M Camargo, V Malkov, A M McIntosh, J K Millar, D H Blackwood, K L Evans, I J Deary, D J Porteous, W R McCombie
Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower cognitive ability, and show evidence of genetic overlap and substantial evidence of pleiotropy with cognitive function and neuroticism. Disrupted in schizophrenia 1 (DISC1) protein directly interacts with a large set of proteins (DISC1 Interactome) that are involved in brain development and signaling. Modulation of DISC1 expression alters the expression of a circumscribed set of genes (DISC1 Regulome) that are also implicated in brain biology and disorder...
June 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28619861/geriatrics-and-the-legal-system
#4
Stephanie C Yarnell, Paul D Kirwin, Howard V Zonana
Correctional systems, already struggling to meet the basic and functional requirements of older prisoners, will be further challenged by the increasing medical and psychiatric needs of this population. Mental health and general medical care for older adults requires specific on-site or consultation expertise in geriatric medicine and psychiatry, as well as potential changes in infrastructure, both of which may be prohibitively expensive. However, compassionate and effective treatment of older prisoners requires that prison and legal systems facilitate this expert care...
June 2017: Journal of the American Academy of Psychiatry and the Law
https://www.readbyqxmd.com/read/28555075/acute-ketamine-administration-corrects-abnormal-inflammatory-bone-markers-in-major-depressive-disorder
#5
B Kadriu, P W Gold, D A Luckenbaugh, M S Lener, E D Ballard, M J Niciu, I D Henter, L T Park, R T De Sousa, P Yuan, R Machado-Vieira, C A Zarate
Patients with major depressive disorder (MDD) have clinically relevant, significant decreases in bone mineral density (BMD). We sought to determine if predictive markers of bone inflammation-the osteoprotegerin (OPG)-RANK-RANKL system or osteopontin (OPN)-play a role in the bone abnormalities associated with MDD and, if so, whether ketamine treatment corrected the abnormalities. The OPG-RANK-RANKL system plays the principal role in determining the balance between bone resorption and bone formation. RANKL is the osteoclast differentiating factor and diminishes BMD...
May 30, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28525731/erratum
#6
(no author information available yet)
Kisely S, Hall K. An updated meta-analysis of randomized controlled evidence for the effectiveness of community treatment orders. Can J Psychiatry. 2014;59(10):561-564. (Original DOI: 10.1177/070674371405901010) On page 563, Figure 1 was printed with incorrect values. The correct values for Figure 1 are below: [Figure: see text].
May 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28487868/severe-symptomatic-acute-hyponatremia-in-traumatic-brain-injury-responded-very-rapidly-to-a-single-15-mg-dose-of-oral-tolvaptan-a-mayo-clinic-health-system-hospital-experience-need-for-caution-with-tolvaptan-in-younger-patients-with-preserved-renal-function
#7
Macaulay Amechi Chukwukadibia Onuigbo, Nneoma Agbasi
Tolvaptan is now well established as a potent pharmaceutical agent for symptomatic hyponatremia from syndrome of inappropriate antidiuretic hormone secretion (SIADH), congestive heart failure and liver cirrhosis. Previous studies had recruited older (63-65 years) patients with mild renal impairment (serum creatinine, 1.3-1.4 mg/dl). A 2012 report in the Journal of Neurology, Neurosurgery & Psychiatry described tolvaptan as a "lifesaving drug". A major outcome concern in the treatment of chronic hyponatremia is potentially fatal pontine demyelination from over-rapid correction of serum sodium >0...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28416813/brain-derived-neurotrophic-factor-val-66-met-genotype-and-ovarian-steroids-interactively-modulate-working-memory-related-hippocampal-function-in-women-a-multimodal-neuroimaging-study
#8
S-M Wei, E B Baller, P D Kohn, J S Kippenhan, B Kolachana, S J Soldin, D R Rubinow, P J Schmidt, K F Berman
Preclinical evidence suggests that the actions of ovarian steroid hormones and brain-derived neurotrophic factor (BDNF) are highly convergent on brain function. Studies in humanized mice document an interaction between estrus cycle-related changes in estradiol secretion and BDNF Val(66)Met genotype on measures of hippocampal function and anxiety-like behavior. We believe our multimodal imaging data provide the first demonstration in women that the effects of the BDNF Val/Met polymorphism on hippocampal function are selectively modulated by estradiol...
April 18, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28284362/-reorganising-a-department-of-psychiatry-according-to-recovery-principles-a-pilot-study-with-mixed-method-design
#9
Gisbert Eikmeier, Luciana Degano Kieser, Mirjam Paap, Jörg Utschakowski, Angelika Lacroix
Considering the impact of mental disorders, control and evaluation of treatment programs are important topics. Here, we report on a pilot study composed of a qualitative and a quantitative part to monitor the recovery-oriented reorganisation of a psychiatric department. For this purpose 13 and 15, respectively, stakeholders of the change management were interviewed between 2012 (T1) and 2014 (T2). Moreover, patients and staff were asked to complete a German version of the Recovery Self Assessment (RSA) questionnaire...
February 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28242871/attenuation-of-ketamine-induced-impairment-in-verbal-learning-and-memory-in-healthy-volunteers-by-the-ampa-receptor-potentiator-pf-04958242
#10
M Ranganathan, N DeMartinis, B Huguenel, F Gaudreault, M M Bednar, C L Shaffer, S Gupta, J Cahill, M A Sherif, J Mancuso, L Zumpano, D C D'Souza
There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity suggests that facilitation of NMDAR function might ameliorate CIAS. One strategy to correct NMDAR hypofunction is to stimulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) as AMPAR and NMDAR functioning are coupled and interdependent. In rats and nonhuman primates (NHP), AMPAR potentiators reduce spatial working memory deficits caused by the nonselective NMDAR antagonist ketamine...
February 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28242869/in-vivo-imaging-of-translocator-protein-a-marker-of-activated-microglia-in-alcohol-dependence
#11
A T Hillmer, C M Sandiego, J Hannestad, G A Angarita, A Kumar, E M McGovern, Y Huang, K C O'Connor, R E Carson, S S O'Malley, K P Cosgrove
Neuroinflammation may be a critical component of the neurobiology of alcohol use disorders, yet the exact nature of this relationship is not well understood. This work compared the brain and peripheral immune profile of alcohol-dependent subjects and controls. Brain levels of 18-kDa translocator protein (TSPO), a marker of microglial activation and neuroinflammation, were measured with [(11)C]PBR28 positron emission tomography imaging in 15 healthy controls and 15 alcohol-dependent subjects. Alcohol-dependent subjects were imaged 1-4 days (n=14) or 24 days (n=1) after their last drink...
February 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28229349/joint-attention-and-the-social-phenotype-of-school-aged-children-with-asd
#12
Peter Mundy, Stephanie Novotny, Lindsey Swain-Lerro, Nancy McIntyre, Matt Zajic, Tasha Oswald
The validity of joint attention assessment in school-aged children with ASD is unclear (Lord, Jones, Journal of Child Psychology and Psychiatry 53(5):490-509, 2012). This study examined the feasibility and validity of a parent-report measure of joint attention related behaviors in verbal children and adolescents with ASD. Fifty-two children with ASD and 34 controls were assessed with the Childhood Joint Attention Rating Scale (C-JARS). The C-JARS exhibited internally consistency, α = 0.88, and one factor explained 49% of the scale variance...
May 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28225844/-diminished-culpability
#13
Luis Ohman, Adrián P Fantini
One of the central matters in forensic psychiatry is its culpability. Day after day we, the mental health professionals, are subpoenaed in different courts of our country to assess the mental state of a given individual in order to endorse a judge so that he can issue their view pertaining the culpability and the responsibility of accused subjects. Our current National Criminal Code, dating from 1921, in Art. 34 sub 1 holds for culpability a dichotomous model in which an individual is responsible and must be accountable for his behavior or not responsible and in such case must no be held accountable in criminal courts...
May 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28220044/pregnenolone-blocks-cannabinoid-induced-acute-psychotic-like-states-in-mice
#14
A Busquets-Garcia, E Soria-Gómez, B Redon, Y Mackenbach, M Vallée, F Chaouloff, M Varilh, G Ferreira, P-V Piazza, G Marsicano
Cannabis-induced acute psychotic-like states (CIAPS) represent a growing health issue, but their underlying neurobiological mechanisms are poorly understood. The use of antipsychotics and benzodiazepines against CIAPS is limited by side effects and/or by their ability to tackle only certain aspects of psychosis. Thus, safer wide-spectrum treatments are currently needed. Although the blockade of cannabinoid type-1 receptor (CB1) had been suggested as a therapeutical means against CIAPS, the use of orthosteric CB1 receptor full antagonists is strongly limited by undesired side effects and low efficacy...
February 21, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28216771/filicide-in-the-united-states
#15
Phillip J Resnick
In the United States the Accreditation Council of Graduate Medical Education determines the curriculum required for fellows in forensic psychiatry to become board certified as a subspecialist. Areas that must be covered during the one year fellowship include criminal issues, such as insanity; civil issues, such as tort law and Workers' Compensation; legal regulation of psychiatry, such as confidentiality and involuntary hospitalization; and correctional psychiatry issues, such as dual agency and prisoner's rights...
December 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28216766/forensic-psychiatry-in-india-past-present-and-future
#16
REVIEW
S Nambi, Siva Ilango, Lakshmi Prabha
Forensic psychiatry is a subspecialty of psychiatry, in which scientific and clinical expertise is applied to legal issues in legal contexts embracing civil, criminal, correctional, or legislative matters. Forensic psychiatry is still in an infant stage in India and other developing countries. Law is the sanctioning discipline, and Psychiatry is the therapeutic discipline. Due to various reasons, Forensic Psychiatry is reared as Cinderella in our country; "which is much neglected, ignored, misinterpreted, and misunderstood...
December 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28194003/lower-levels-of-the-glial-cell-marker-tspo-in-drug-naive-first-episode-psychosis-patients-as-measured-using-pet-and-11-c-pbr28
#17
K Collste, P Plavén-Sigray, H Fatouros-Bergman, P Victorsson, M Schain, A Forsberg, N Amini, S Aeinehband, S Erhardt, C Halldin, L Flyckt, L Farde, S Cervenka
Several lines of evidence are indicative of a role for immune activation in the pathophysiology of schizophrenia. Nevertheless, studies using positron emission tomography (PET) and radioligands for the translocator protein (TSPO), a marker for glial activation, have yielded inconsistent results. Whereas early studies using a radioligand with low signal-to-noise in small samples showed increases in patients, more recent studies with improved methodology have shown no differences or trend-level decreases. Importantly, all patients investigated thus far have been on antipsychotic medication, and as these compounds may dampen immune cell activity, this factor limits the conclusions that can be drawn...
June 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28174594/preventing-involuntary-admissions-special-needs-for-distinct-patient-groups
#18
Knut Hoffmann, I S Haussleiter, F Illes, J Jendreyschak, A Diehl, B Emons, C Armgart, A Schramm, G Juckel
BACKGROUND: Coercive measures in psychiatry are a controversial topic and raise ethical, legal and clinical issues. Involuntary admission of patients is a long-lasting problem and indicates a problematic pathway to care situations within the community, largely because personal freedom is fundamentally covered by the UN declaration of human rights and the German constitution. METHODS: In this study, a survey on a large and comprehensive population of psychiatric in-patients in the eastern part of North Rhine-Westphalia, Germany, was carried out for the years 2004-2009, including 230...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28117060/trajectories-of-substance-use-disorder-in-youth-after-detention-a-12-year-longitudinal-study
#19
Leah J Welty, Jennifer A Hershfield, Karen M Abram, Hongyun Han, Gayle R Byck, Linda A Teplin
OBJECTIVE: To identify trajectories of substance use disorders (SUDs) in youth during the 12 years after detention and how gender, race/ethnicity, and age at baseline predict trajectories. METHOD: As part of the Northwestern Juvenile Project, a longitudinal study of 1,829 youth randomly sampled from detention in Chicago, Illinois from 1995 through 1998, participants were reinterviewed in the community or correctional facilities up to 9 times over 12 years. Independent interviewers assessed SUDs using the Diagnostic Interview Schedule for Children 2...
February 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28093568/gwas-meta-analysis-reveals-novel-loci-and-genetic-correlates-for-general-cognitive-function-a-report-from-the-cogent-consortium
#20
J W Trampush, M L Z Yang, J Yu, E Knowles, G Davies, D C Liewald, J M Starr, S Djurovic, I Melle, K Sundet, A Christoforou, I Reinvang, P DeRosse, A J Lundervold, V M Steen, T Espeseth, K Räikkönen, E Widen, A Palotie, J G Eriksson, I Giegling, B Konte, P Roussos, S Giakoumaki, K E Burdick, A Payton, W Ollier, M Horan, O Chiba-Falek, D K Attix, A C Need, E T Cirulli, A N Voineskos, N C Stefanis, D Avramopoulos, A Hatzimanolis, D E Arking, N Smyrnis, R M Bilder, N A Freimer, T D Cannon, E London, R A Poldrack, F W Sabb, E Congdon, E D Conley, M A Scult, D Dickinson, R E Straub, G Donohoe, D Morris, A Corvin, M Gill, A R Hariri, D R Weinberger, N Pendleton, P Bitsios, D Rujescu, J Lahti, S Le Hellard, M C Keller, O A Andreassen, I J Deary, D C Glahn, A K Malhotra, T Lencz
The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT)...
March 2017: Molecular Psychiatry
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