Xiangheng Cai, Jinglin Cao, Le Wang, Jiaqi Zou, Rui Li, Peng Sun, Xuejie Ding, Boya Zhang, Zewen Liu, Xirui Pei, Jiuxia Yang, Yixiang Zhan, Na Liu, Tengli Liu, Rui Liang, Jie Gao, Shusen Wang
BACKGROUND: Islet transplantation is a promising therapy for patients with type 1 diabetes. However, ischemic injury to the donor islets during cold preservation leads to reduced islet quality and compromises transplant outcome. Several studies imply that liraglutide, a glucagon-like peptide-1 receptor agonist, has a positive effect on promoting islet survival, but its impact on islet cold-ischemic injury remains unexplored. Therefore, the aim of this study was to investigate whether liraglutide can improve islet transplantation efficacy by inhibiting cold-ischemic injury and to explore the underlying mechanisms...
April 5, 2024: Transplantation