Cynthia D Jesudason, Emily R Mason, Shaoyou Chu, Adrian L Oblak, June Javens-Wolfe, Mustapha Moussaif, Greg Durst, Philip Hipskind, Daniel E Beck, Jiajun Dong, Ovini Amarasinghe, Zhong-Yin Zhang, Adam K Hamdani, Kratika Singhal, Andrew D Mesecar, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Disha M Soni, Murugesh Kandasamy, Andrea R Masters, Sara K Quinney, Suzanne Doolen, Hasi Huhe, Stacey J Sukoff Rizzo, Bruce T Lamb, Alan D Palkowitz, Timothy I Richardson
INTRODUCTION: The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate-5-phosphatase ( INPP5D ), which encodes Src homology 2 (SH2) domain-containing inositol polyphosphate 5-phosphatase 1 (SHIP1), is a risk gene expressed in microglia. Because SHIP1 binds receptor immunoreceptor tyrosine-based inhibitory motifs (ITIMs), competes with kinases, and converts PI(3,4,5)P3 to PI(3,4)P2 , it is a negative regulator of microglia function...
2023: Alzheimer's & Dementia: Translational Research & Clinical Interventions