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HIV and Quality of Life

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https://www.readbyqxmd.com/read/28811073/quality-of-life-of-people-living-with-hiv-compared-with-that-of-the-general-population-in-japan
#1
Shinichi Hikasa, Shota Shimabukuro, Kyoko Hideta, Norihiro Kuroda, Satoshi Higasa, Akihiro Sawada, Tazuko Tokugawa, Asuka Ikegami, Asuna Kotani, Takeshi Kimura
OBJECTIVE: To evaluate the health-related quality of life (HRQOL) of people living with HIV (PLWH) in Japan. METHODS: A cross-sectional comparative study was conducted between June and December 2016 on PLWH. HRQOL was assessed using the Japanese version of the Short Form-36 Health Survey questionnaire (SF-36), and the three-component model of SF-36 scores was used. The values from the present study were compared with the published general Japanese values. Multivariate analysis was performed to identify the independent factors associated with the HRQOL of PLWH...
August 12, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28810475/hiv-symptom-management-self-efficacy-mediates-the-relationship-of-internalized-stigma-and-quality-of-life-among-people-living-with-hiv-in-china
#2
Guangyu Zhou, Xiaoming Li, Shan Qiao, Zhiyong Shen, Yuejiao Zhou
HIV-related stigma negatively influences quality of life among people living with HIV. Little is known about psychological protective factors that mitigate negative impacts. This study aims to examine the role of self-efficacy in reducing effects of stigma on quality of life. A total of 2987 people living with HIV (age: M = 42.46 years, SD = 12.83; time since diagnosis: M = 3.23 years, SD = 2.39) provided data on internalized stigma, HIV symptom management self-efficacy, and health-related quality of life, as well as covariates...
June 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28803049/modeling-aging-in-hiv-infection-in-nonhuman-primates-to-address-an-emerging-challenge-of-the-post-art-era
#3
REVIEW
Tianyu He, Elizabeth Falwell, Egidio Brocca-Cofano, Ivona Pandrea
The advent of antiretroviral therapy (ART) has dramatically improved both quality and length of life for subjects infected with human immunodeficiency virus (HIV), delaying or preventing progression to acquired immunodeficiency syndrome (AIDS). However, the virus induces aging-related changes to the immune system which confound treatment. Additionally, the normal physiologic events that occur during aging lead to deficiencies in immunity which not only exacerbate HIV pathogenesis but also trigger a variety of comorbidities...
August 9, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28801004/the-palliative-care-journey-in-kenya-and-uganda
#4
Emmanuel S Kamonyo
Palliative care is "an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial and spiritual. This update is aimed at examining palliative care development/achievements and challenges in Kenya and Uganda and the role of various actors in palliative care establishment in the region...
August 8, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28795954/the-first-characterization-of-hiv-1-subtypes-and-drug-resistance-mutations-among-antiretrovirally-treated-patients-in-kermanshah-iran
#5
Reza Golmohammadi, Kazem Baesi, Abdolvahab Moradi, Molood Farrokhi, Willi McFarland, Shahryar Parsamajd
BACKGROUND: Insufficient therapy during HIV-1 replication can promote the emergence of drug-resistant strains, reduce the effectiveness of antiretroviral treatment (ART), and increase the likelihood of the onward transmission of drug-resistant viruses. We characterized, for the first time, the prevalence of HIV-1 subtypes and drug resistance mutations in a western region of Iran. METHODS: This study was conducted among 122 patients on ART at a major referral center in Kermanshah, Iran...
August 10, 2017: Intervirology
https://www.readbyqxmd.com/read/28793074/sustainability-of-arv-provision-in-developing-countries-challenging-a-framework-based-on-program-history
#6
Thiago Botelho Azeredo, Maria Auxiliadora Oliveira, Cláudia Du Bocage Santos-Pinto, Elaine Silva Miranda, Claudia Garcia Serpa Osorio-de-Castro
The provision of ARVs is central to HIV/AIDS programs, because of its impact on the course of the disease and on quality of life. Although first-line treatments costs have declined, treatment-associated expenses are steeper each year. Sustainability is therefore an important variable for the success of treatment programs. A conceptual framework on sustainability of ARV provision was developed, followed by data collection instruments. The pilot study was undertaken in Brazil. Bolivia, Peru and Mozambique, were visited...
August 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28793015/virulence-factors-and-genetic-variability-of-vaginal-candida-albicans-isolates-from-hiv-infected-women-in-the-post-highly-active-antiretroviral-era
#7
Pâmela Cristina Mastellaro Delvas Zanni, Patrícia de Souza Bonfim-Mendonça, Melyssa Negri, Sandra Sayuri Nakamura, Lucélia Donatti, Terezinha Inez Estivalet Svidzinski, Márcia Edilaine Lopes Consolaro
Vulvovaginal candidiasis (VVC) in HIV-infected (HIV+) women is a serious public health problem. However, little is known about the virulence mechanisms of vaginal Candida albicans from HIV+ women in the post-highly active antiretroviral therapy (HAART) era. Here, we report a comparative analysis of the expression of key virulence factors and genetic variability of 26 vaginal C. albicans strains isolated from HIV+ women undergoing HAART and 18 from HIV-uninfected (HIV-) women. In general, we observed that C...
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28789630/moderate-endurance-training-marathon-training-effects-on-immunologic-and-metabolic-parameters-in-hiv-infected-patients-the-42-km-cologne-project
#8
Stefan Schlabe, Martin Vogel, Christoph Boesecke, Carolynne Schwarze-Zander, Jürgen K Rockstroh, Christian Körner, Klara Brixius, Jan-Christian Wasmuth
BACKGROUND: Improved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce. METHODS: 21 HIV-infected persons were monitored prospectively while preparing for a marathon run. Multiple parameters with regard to immunology, quality of life and metabolism were measured at 4 time points (at baseline 1 year before the marathon run, 3 and 6 months after beginning of training, and immediately before marathon)...
August 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28780631/gbv-c-hiv-1-coinfection-is-associated-with-low-hiv-1-viral-load-and-high-cd4-t-lymphocyte-count
#9
Bárbara Katharine Barbosa de Miranda, Keyla Santos Guedes de Sá, Andrea Nazaré Rangel da Silva, Rosimar Neris Martins Feitosa, Izaura Maria Vieira Cayres-Vallinoto, Ricardo Ishak, Antonio Carlos Rosário Vallinoto
GB virus C (GBV-C) is a lymphotropic virus with a low level or non-existent replication in the liver. The interaction between HIV-1 and GBV-C apparently reduces the progression of HIV-1 infection to AIDS and improves the quality of life of HIV-1 infected individuals. A cross-sectional study was established to determine the possible effect of HIV-1/GBV-C coinfection on HIV-1 viral load and CD4(+) T lymphocyte counts. Samples from 313 HIV-1 infected persons from the Virus Laboratory of the Federal University of Pará as well as demographic and clinical information were obtained from medical records...
August 5, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28774191/household-decision-making-power-and-the-mental-health-and-well-being-of-women-initiating-antiretroviral-treatment-in-oromia-ethiopia
#10
Angela M Parcesepe, Olga Tymejczyk, Robert Remien, Tsigereda Gadisa, Sarah Gorrell Kulkarni, Susie Hoffman, Zenebe Melaku, Batya Elul, Denis Nash
Low decision-making power (DMP) has been associated with HIV seropositivity among women in sub-Saharan Africa. As treatment accessibility and life expectancy for HIV-positive individuals increase, greater attention to the mental health and well-being of HIV-positive women is needed. This study examined whether low DMP was associated with psychological distress, social support or health-related quality of life (HRQoL) among women initiating ART. The sample included 722 women aged 18 or older initiating ART during 2012-2013 at six HIV clinics in Oromia, Ethiopia...
August 3, 2017: AIDS Care
https://www.readbyqxmd.com/read/28770641/evidence-on-the-cost-effectiveness-of-lifelong-antiretroviral-therapy-for-prevention-of-mother-to-child-transmission-of-hiv-implications-for-resource-limited-countries-in-sub-saharan-africa
#11
Peslie G Ngambi, Aubrey C Kalungia, Michael R Law, Francis Kalemeera, IIse Truter, Brian Godman, Derick Munkombwe
The 2016 World Health Organization (WHO) consolidated guideline recommends lifelong antiretroviral therapy (ART) for all HIV-infected pregnant and breastfeeding women for preventing mother-to-child HIV transmission (PMTCT). Ambiguity remains about the cost-effectiveness of this strategy in resource-limited developing countries. Areas Covered: We reviewed model-based studies on the cost-effectiveness of lifelong ART (formerly Option B+) relative to previous WHO guidelines for PMTCT. Our search using PubMed, Medline and Google Scholar for articles on Option B+ resulted in the final inclusion of seven studies published between 2012 and 2016...
August 3, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28768604/cost-effectiveness-of-screening-for-hiv-in-primary-care-a-health-economics-modelling-analysis
#12
Rebecca F Baggaley, Michael A Irvine, Werner Leber, Valentina Cambiano, Jose Figueroa, Heather McMullen, Jane Anderson, Andreia C Santos, Fern Terris-Prestholt, Alec Miners, T Déirdre Hollingsworth, Chris J Griffiths
BACKGROUND: Early HIV diagnosis reduces morbidity, mortality, the probability of onward transmission, and their associated costs, but might increase cost because of earlier initiation of antiretroviral treatment (ART). We investigated this trade-off by estimating the cost-effectiveness of HIV screening in primary care. METHODS: We modelled the effect of the four-times higher diagnosis rate observed in the intervention arm of the RHIVA2 randomised controlled trial done in Hackney, London (UK), a borough with high HIV prevalence (≥0·2% adult prevalence)...
July 28, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28766027/telephone-delivered-mindfulness-training-for-people-living-with-hiv-a-qualitative-360%C3%A2-inquiry
#13
Rochelle K Rosen, Larissa A McGarrity, Elena Salmoirago-Blotcher, Carla Rich, Aadia Rana, Michael P Carey
For people living with HIV and AIDS (PLWHA), life stress often undermines quality of life and interferes with medical care. Mindfulness training (MT) may help PLWHA to manage stress. Because standard MT protocols can be burdensome, we explored telephone delivery as a potentially more feasible approach. We used an innovative 360° qualitative inquiry to seek input regarding telephone-delivery of MT for PLWHA in advance of a planned intervention trial. We also sought input on a time- and attention-matched control...
August 1, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28764704/objective-impairments-of-gait-and-balance-in-adults-living-with-hiv-1-infection-a-systematic-review-and-meta-analysis-of-observational-studies
#14
Karina Berner, Linzette Morris, Jochen Baumeister, Quinette Louw
BACKGROUND: Gait and balance deficits are reported in adults with HIV infection and are associated with reduced quality of life. Current research suggests an increased fall-incidence in this population, with fall rates among middle-aged adults with HIV approximating that in seronegative elderly populations. Gait and postural balance rely on a complex interaction of the motor system, sensory control, and cognitive function. However, due to disease progression and complications related to ongoing inflammation, these systems may be compromised in people with HIV...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28764205/prevalence-and-patterns-of-multimorbidity-among-human-immunodeficiency-virus-positive-people-in-odisha-india-an-exploratory-study
#15
Sanghamitra Pati, Shreeporna Bhattacharya, Subhashisa Swain
INTRODUCTION: Improved and efficient Anti-Retroviral Therapy (ART) has turned HIV positive into a chronic disorder. The increase in life expectancy and quality of life comes with an increased risk of multimorbidity from the traditional risk factors. AIM: To explore the prevalence of multimorbidity among People Living with HIV (PLHIV). MATERIALS AND METHODS: An exploratory cross-sectional study was carried out in an ART center of Odisha, India, from November 2013 to December 2013...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28754302/immunometabolic-and-lipidomic-markers-associated-with-the-frailty-index-and-quality-of-life-in-aging-hiv-men-on-antiretroviral-therapy
#16
Hui-Ling Yeoh, Allen C Cheng, Catherine L Cherry, Jacquelyn M Weir, Peter J Meikle, Jennifer F Hoy, Suzanne M Crowe, Clovis S Palmer
Chronic immune activation persists despite antiretroviral therapy (ART) in HIV+ individuals and underpins an increased risk of age-related co-morbidities. We assessed the Frailty Index in older HIV+ Australian men on ART. Immunometabolic markers on monocytes and T cells were analyzed using flow cytometry, plasma innate immune activation markers by ELISA, and lipidomic profiling by mass spectrometry. The study population consisted of 80 HIV+ men with a median age of 59 (IQR, 56-65), and most had an undetectable viral load (92%)...
August 2017: EBioMedicine
https://www.readbyqxmd.com/read/28746656/mortality-due-to-noncommunicable-diseases-in-brazil-1990-to-2015-according-to-estimates-from-the-global-burden-of-disease-study
#17
Deborah Carvalho Malta, Elisabeth França, Daisy Maria Xavier Abreu, Rosângela Durso Perillo, Maíra Coube Salmen, Renato Azeredo Teixeira, Valeria Passos, Maria de Fátima Marinho Souza, Meghan Mooney, Mohsen Naghavi
CONTEXT AND OBJECTIVE: Noncommunicable diseases (NCDs) are the leading health problem globally and generate high numbers of premature deaths and loss of quality of life. The aim here was to describe the major groups of causes of death due to NCDs and the ranking of the leading causes of premature death between 1990 and 2015, according to the Global Burden of Disease (GBD) 2015 study estimates for Brazil. DESIGN AND SETTING: Cross-sectional study covering Brazil and its 27 federal states...
May 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28746573/quality-of-life-socioeconomic-and-clinical-factors-and-physical-exercise-in-persons-living-with-hiv-aids
#18
Rafaela Catherine da Silva Cunha de Medeiros, Jason Azevedo de Medeiros, Tatiane Andreza Lima da Silva, Ricardo Dias de Andrade, Danielle Coutinho de Medeiros, Juliany de Souza Araújo, Antônio Manuel Gouveia de Oliveira, Marcos Aurélio de Albuquerque Costa, Paulo Moreira Silva Dantas
OBJECTIVE: To analyze whether socioeconomic and clinical aspects and the aspects of healthy life habits are associated with the quality of life of persons living with HIV/AIDS. METHODS: This is a cross-sectional exploratory quantitative research, with 227 persons living with HIV/AIDS, treated at two hospitals of reference between April 2012 and June 2014. We used structured questionnaires to assess socioeconomic aspects (gender, age, education level, marital status, race, socioeconomic status, dependents on family income, employment relationship), clinical parameters (time of disease diagnosis, use and time of medication, CD4 T-cell count, and viral load), and practice of physical exercise...
July 20, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28744106/evaluating-patient-preference-and-satisfaction-for-human-immunodeficiency-virus-therapy-in-france
#19
Sylvie Brégigeon-Ronot, Antoine Cheret, André Cabié, Thierry Prazuck, Alain Volny-Anne, Shehzad Ali, Catherine Bottomley, Laurent Finkielsztejn, Caroline Philippe, Jean-Jacques Parienti
OBJECTIVES: The objectives were 1) to elicit relative preferences for attributes of antiretroviral therapies (ART) in people living with HIV (PLWH) and 2) to explore satisfaction and adherence with current ART. PATIENTS AND METHODS: We conducted a multicenter cross-sectional study, consecutively enrolling PLWH receiving an ART. The quantitative part estimated the strength of preference for different attributes using an online discrete choice experiment (DCE). DCE data were analyzed using a mixed logit regression model...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28743254/association-between-serotonin-transporter-gene-polymorphisms-and-increased-suicidal-risk-among-hiv-positive-patients-in-uganda
#20
Allan Kalungi, Soraya Seedat, Sian M J Hemmings, Lize van der Merwe, Moses L Joloba, Ann Nanteza, Noeline Nakassujja, Harriet Birabwa, Jennifer Serwanga, Pontiano Kaleebu, Eugene Kinyanda
BACKGROUND: Persons living with HIV/AIDS (PLWHA) are at an increased risk of suicide. Increased suicidal risk is a predictor of future attempted and completed suicides and has been associated with poor quality of life and poor adherence with antiretroviral therapy. Clinical risk factors have low predictive value for suicide, hence the interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. The serotonin transporter gene has previously been implicated in the aetiology of increased suicidal risk in non-HIV infected study populations and its variations may provide a platform for identifying genetic risk for suicidality among PLWHA...
July 25, 2017: BMC Genetics
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