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HIV and Quality of Life

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https://www.readbyqxmd.com/read/28547996/predicting-health-related-quality-of-life-in-people-living-with-hiv-in-nepal-mental-health-disorders-and-substance-use-determinants
#1
Khem N Pokhrel, Vidya D Sharma, Akira Shibanuma, Kalpana G Pokhrel, Linda B Mlunde, Masamine Jimba
HIV-positive people often experience mental health disorders and engage in substance use. Such conditions tend to impair their health-related quality of life (QOL). Evidence, however, is limited about the influence of mental health disorders and substance use on QOL by gender. Also, little is known about the influences of anxiety and high levels of stress on QOL. We recruited 682 HIV-positive people in Nepal and measured their depression, anxiety, stress levels, substance use, and QOL. Multiple linear regressions assessed the association of mental health disorders and substance use with QOL...
May 26, 2017: AIDS Care
https://www.readbyqxmd.com/read/28542796/interleukin-2-as-an-adjunct-to-antiretroviral-therapy-for-hiv-positive-adults
#2
REVIEW
Jennifer Onwumeh, Charles I Okwundu, Tamara Kredo
BACKGROUND: Human immunodeficiency virus (HIV) continues to be a leading cause of morbidity and mortality, particularly in sub-Saharan Africa. Although antiretroviral drugs have helped to improve the quality of life and life expectancy of HIV-positive individuals, there is still a need to explore other interventions that will help to further reduce the disease burden. One potential strategy is the use of interleukin-2 (IL-2) in combination with antiretroviral therapy (ART). IL-2 is a cytokine that regulates the proliferation and differentiation of lymphocytes and may help to boost the immune system...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28542184/estimation-of-the-cost-effectiveness-of-hiv-prevention-portfolios-for-people-who-inject-drugs-in-the-united-states-a-model-based-analysis
#3
Cora L Bernard, Douglas K Owens, Jeremy D Goldhaber-Fiebert, Margaret L Brandeau
BACKGROUND: The risks of HIV transmission associated with the opioid epidemic make cost-effective programs for people who inject drugs (PWID) a public health priority. Some of these programs have benefits beyond prevention of HIV-a critical consideration given that injection drug use is increasing across most United States demographic groups. To identify high-value HIV prevention program portfolios for US PWID, we consider combinations of four interventions with demonstrated efficacy: opioid agonist therapy (OAT), needle and syringe programs (NSPs), HIV testing and treatment (Test & Treat), and oral HIV pre-exposure prophylaxis (PrEP)...
May 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28536741/does-diagnosis-make-a-difference-estimating-the-impact-of-an-hiv-medication-adherence-intervention-for-persons-with-serious-mental-illness
#4
Natasha Dalseth, Regina Szucs Reed, Michael Hennessy, Marlene M Eisenberg, Michael B Blank
The heightened risk of persons with serious mental illness to contract and transmit human immunodeficiency virus (HIV) is a public health problem. Here we evaluate the interaction between psychiatric diagnosis and response to a community based-intervention targeted at treatment adherence in 236 HIV+ persons with co-occurring mental illness. To examine differential effectiveness of the intervention for categories of patient diagnosis, we reanalyzed the data after stratifying participants into two diagnostic groups: (1) participants with depressive disorders without psychosis and (2) participants with a psychotic or bipolar disorder...
May 23, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28535397/quality-of-life-anxiety-and-depression-in-patients-with-hiv-aids-who-present-poor-adherence-to-antiretroviral-therapy-a-cross-sectional-study-in-salvador-brazil
#5
Mónica Narváez Betancur, Liliane Lins, Irismar Reis de Oliveira, Carlos Brites
The introduction of highly active antiretroviral therapy marked a major gain in efficacy of HIV/AIDS treatment and a reduction in morbidity and mortality of the infected patients. However, high levels of adherence are required to obtain virologic suppression. In Brazil, the policy of free and universal access to antiretroviral therapy has been in place since 1996, although there are reports of poor adherence. OBJECTIVE: To define the clinical, demographic and psychological characteristics, and quality of life of patients with HIV/AIDS who present poor adherence to highly active antiretroviral therapy...
May 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28534093/quality-of-life-among-perinatally-hiv-affected-and-hiv-unaffected-school-aged-and-adolescent-ugandan-children-a-multi-dimensional-assessment-of-wellbeing-in-the-post-haart-era
#6
A K Nkwata, S K Zalwango, F N Kizza, J N Sekandi, J Mutanga, M Zhang, P M Musoke, A E Ezeamama
OBJECTIVE: To examine quality of life (QOL) in perinatally HIV-infected (PHIV) or HIV-exposed uninfected (PHEU) vs. healthy HIV-unexposed uninfected (HUU) children during school-age/adolescence. METHODS: PHIV infection was diagnosed via DNA PCR. Current HIV status was confirmed by HIV rapid diagnostic test. Three HIV groups were defined: PHIV, PHEU, and HUU. QOL was assessed with proxy and self-report versions of the PedsQL™ 4.0 instrument at 6-18 years of age...
May 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28532308/contributions-of-national-and-global-health-estimates-to-monitoring-health-related-sustainable-development-goals-in-thailand
#7
Kanitta Bundhamcharoen, Supon Limwattananon, Khanitta Kusreesakul, Viroj Tangcharoensathien
The Millennium Development Goals (MDGs) triggered increased demand for data on child and maternal mortality for monitoring progress. With the advent of the Sustainable Development Goals (SDGs) and growing evidence of an epidemiological transition towards non-communicable diseases, policy makers need data on mortality and disease trends and distribution to inform effective policies and support monitoring progress. Where there are limited capacities to produce national health estimates (NHEs), global health estimates (GHEs) can fill gaps for global monitoring and comparisons...
January 2017: Global Health Action
https://www.readbyqxmd.com/read/28529359/the-journey-of-opioid-substitution-therapy-in-india-achievements-and-challenges
#8
Ravindra Rao
Opioids are one of the most problematic illegal substances globally. Opioid abuse is associated with complications in various spheres of the user's life, his/her family, and the society. Injecting drug use (IDU) is also linked to public health problems such as HIV infection and viral hepatitis. Medications form an important cornerstone in the treatment of opioid dependence. Treatment strategies such as "detoxification" alone or long-term treatment with opioid antagonist have limited acceptability and retention rates...
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28511680/cohort-profile-seek-test-treat-and-retain-united-states-criminal-justice-cohort
#9
Redonna Chandler, Michael S Gordon, Bridget Kruszka, Lauren N Strand, Frederick L Altice, Curt G Beckwith, Mary L Biggs, William Cunningham, J A Chris Delaney, Patrick M Flynn, Carol E Golin, Kevin Knight, Alex H Kral, Irene Kuo, Jennifer Lorvick, Robin M Nance, Lawrence J Ouellet, Josiah D Rich, Stanley Sacks, David Seal, Anne Spaulding, Sandra A Springer, Faye Taxman, David Wohl, Jeremy D Young, Rebekah Young, Heidi M Crane
BACKGROUND: The STTR treatment cascade provides a framework for research aimed at improving the delivery of services, care and outcomes of PLWH. The development of effective approaches to increase HIV diagnoses and engage PLWH in subsequent steps of the treatment cascade could lead to earlier and sustained ART treatment resulting in viral suppression. There is an unmet need for research applying the treatment cascade to improve outcomes for those with criminal justice involvement. METHODS: The Seek, Test, Treat, and Retain (STTR) criminal justice (CJ) cohort combines data from 11 studies across the HIV treatment cascade that focused on persons involved in the criminal justice system, often but not exclusively for reasons related to substance use...
May 16, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28511559/migrating-microbes-what-pathogens-can-tell-us-about-population-movements-and-human-evolution
#10
Charlotte J Houldcroft, Jean-Baptiste Ramond, Riaan F Rifkin, Simon J Underdown
BACKGROUND: The biology of human migration can be observed from the co-evolutionary relationship with infectious diseases. While many pathogens are brief, unpleasant visitors to human bodies, others have the ability to become life-long human passengers. The story of a pathogen's genetic code may, therefore, provide insight into the history of its human host. The evolution and distribution of disease in Africa is of particular interest, because of the deep history of human evolution in Africa, the presence of a variety of non-human primates, and tropical reservoirs of emerging infectious diseases...
May 16, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28489467/use-of-opioid-substitution-therapies-in-the-treatment-of-opioid-use-disorder-results-of-a-uk-cost-effectiveness-modelling-study
#11
James Kenworthy, Yunni Yi, Antony Wright, Jim Brown, Ana Maria Madrigal, William C N Dunlop
AIMS: This study investigated the cost-effectiveness of buprenorphine maintenance treatment (BMT) and methadone maintenance treatment (MMT) vs no opioid substitution therapy (OST) for the treatment of opioid use disorder, from the UK National Health Service (NHS)/personal social services (PSS) and societal perspectives over 1 year. METHODS: Cost-effectiveness of OST vs no OST was evaluated by first replicating and then expanding an existing UK health technology assessment model...
May 25, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28484508/cohort-profile-the-complications-of-long-term-antiretroviral-therapy-study-in-uganda-coltart-a-prospective-clinical-cohort
#12
Billy Nsubuga Mayanja, Ivan Kasamba, Jonathan Levin, Ivan Namakoola, Patrick Kazooba, Jackson Were, Pontiano Kaleebu, Paula Munderi
BACKGROUND: Antiretroviral therapy (ART) improves the survival and quality of life of HIV-positive individuals, but the effects of long-term ART use do eventually manifest. The Complications of Long-Term Antiretroviral Therapy cohort study in Uganda (CoLTART) was established to investigate the metabolic and renal complications of long-term ART use among Ugandan adults. We describe the CoLTART study set-up, aims, objectives, study methods, and also report some preliminary cross-sectional study enrolment metabolic and renal complications data analysis results...
2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28479413/self-reported-bothersome-symptoms-across-different-socioepidemiological-groups-of-people-living-with-hiv-attending-french-hospitals-results-from-the-anrs-vespa2-survey
#13
Véronique Boyer, Antoine Vilotitch, Fabienne Marcellin, Baptiste Demoulin, Rosemary Dray-Spira, Bruno Spire
CONTEXT: Twenty years after the advent of combined antiretroviral therapies (cART), there is a growing need for up-to-date information about the daily experience of people living with HIV (PLWH). OBJECTIVES: This study aimed to investigate the relationship between socio-epidemiological groups and the types of bothersome symptoms reported by PLWH participating in a national survey in France. METHODS: We analyzed self-reported bothersome symptoms in a representative sample of PLWH (ANRS VESPA2 survey), most of whom were receiving ART treatment...
May 4, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28473182/quality-of-life-among-women-living-with-hiv-in-rural-india
#14
Adeline M Nyamathi, Maria Ekstrand, Kartik Yadav, Padma Ramakrishna, Elsa Heylen, Catherine Carpenter, Sarah Wall, Tanya Oleskowicz, Lenore Arab, Sanjeev Sinha
A cross-sectional examination was conducted on quality of life (QOL) among women living with HIV (WLWH) in rural Andhra Pradesh, India. Baseline data were collected from 400 WLWH and their children. QOL was measured with 10 items from the Quality of Life Enjoyment and Satisfaction Questionnaire. Findings revealed low QOL scores; on a scale from 0 to 3, the mean QOL score was 0.38 (SD = 0.30). Depression symptoms were reported by 25.5%, internalized stigma was high, and most reported little to no social support...
March 24, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28473001/cohort-profile-the-complications-of-long-term-antiretroviral-therapy-study-in-uganda-coltart-a-prospective-clinical-cohort
#15
Billy Nsubuga Mayanja, Ivan Kasamba, Jonathan Levin, Ivan Namakoola, Patrick Kazooba, Jackson Were, Pontiano Kaleebu, Paula Munderi
BACKGROUND: Antiretroviral therapy (ART) improves the survival and quality of life of HIV-positive individuals, but the effects of long-term ART use do eventually manifest. The Complications of Long-Term Antiretroviral Therapy cohort study in Uganda (CoLTART) was established to investigate the metabolic and renal complications of long-term ART use among Ugandan adults. We describe the CoLTART study set-up, aims, objectives, study methods, and also report some preliminary cross-sectional study enrolment metabolic and renal complications data analysis results...
May 4, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28465652/magnitude-of-antiretroviral-drug-toxicity-in-adult-hiv-patients-in-ethiopia-a-cohort-study-at-seven-teaching-hospitals
#16
Esayas Kebede Gudina, Alula M Teklu, Asres Berhan, Atsbeha Gebreegziabhier, Teshome Seyoum, Abiy Nega, Girmay Medhin, Amha Kebede, Yibeltal Assefa
BACKGROUND: The introduction of antiretroviral therapy (ART) has resulted in significant mortality reduction and improvement in the quality of life. However, this has come at a cost of increased drug toxicity. The objective of this study was to assess the patterns and predictors of ART toxicity in adult HIV patients in Ethiopia. METHODS: This is a prospective cohort study conducted at seven teaching hospitals between September 2009 and December 2013 involving 3921 HIV patients on ART...
February 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/28459866/psychosocial-challenges-facing-women-living-with-hiv-during-the-perinatal-period-in-rural-uganda
#17
Scholastic Ashaba, Angela Kaida, Jessica N Coleman, Bridget F Burns, Emma Dunkley, Kasey O'Neil, Jasmine Kastner, Naomi Sanyu, Cecilia Akatukwasa, David R Bangsberg, Lynn T Matthews, Christina Psaros
The complexities of navigating pregnancy while living with HIV predispose women to additional stress. Finding ways to minimize psychosocial challenges during the perinatal period may maximize the well-being of mothers living with HIV and their children. The goal of this study was to explore psychosocial challenges experienced by women living with HIV (WLWH) during pregnancy and the postpartum. We conducted individual in-depth interviews with 20 WLWH recruited from an HIV treatment cohort study in Mbarara, Uganda as part of a larger study exploring perinatal depression...
2017: PloS One
https://www.readbyqxmd.com/read/28457951/hiv-tat-and-dopaminergic-transmission
#18
REVIEW
Peter Gaskill, Doug Miller, Joyonna-Gamble George, Hideaki Yano, Habibeh Khoshbouei
Human Immunodeficiency Virus (HIV) is a progressive infection that targets the immune system, affecting more than 37 million people around the world. While combinatorial antiretroviral therapy (cART) has lowered mortality rates and improved quality of life in infected individuals, the prevalence of HIV associated neurocognitive disorders is increasing and HIV associated cognitive decline remains prevalent. Recent research has suggested that HIV accessory proteins may be involved in this decline, and several studies have indicated that the HIV protein transactivator of transcription (Tat) can disrupt normal neuronal and glial function...
April 27, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28453023/-hiv-aids-infection-in-children-and-adolescents-chilean-cohort-1987-2014
#19
Elba Wu, M Isabel Galaz, Carmen Larrañaga, Ana Chávez, Marcela González, Ana M Álvarez, Anamaría Peña, Juila Vlllarroel, Eloísa Vizueta
The present document describes the Cohort of HIV/AIDS children detected in Chile from 1987 to August 2014 and the effectiveness of the Protocol for Prevention of Vertical Transmission (PPVT) of HIV infection. Of the 375 HIV infected children enrolled since 1987 to August 2014, 245 of them are still in pediatric control. From the analysis of the Cohort is inferred that: a) it has observed an improvement in the detection of the HIV infected child, in number and precocious time; b) the majority of these children continue to be detected by clinic symptoms and signs (mainly unspecific and infectious manifestations); c) the ARVT use has meant a clinic and immunologic improvement with diminution of the infections, principally opportunistic infections, with a better life quality, a prolongation of survival and a diminution of lethality; d) as more survival has been produced, cancer has begun to be detected, a very infrequent complication observed in them before the ARVT use...
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28452731/quality-of-life-of-people-living-with-hiv-identification-of-the-determinants
#20
D Mauyenova, L Karp, B Zhussupov, M Abilmazhinov
The high prevalence rate of HIV worldwide, including the Republic of Kazakhstan (the RK), in large cities in particular, underlies the tremendous significance of this medical condition for society, economy, demography and healthcare. The objective of this study was to identify the most important determinants of quality of life (QL) of people living with HIV in a large city. The study was carried out in 3 stages. At the first stage, the HIV morbidity and PLH mortality figures over the period of 10 years (2005-2014) in a metropolis (the city of Astana) were analyzed in comparison to the general ones for the Republic...
February 2017: Georgian Medical News
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