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https://www.readbyqxmd.com/read/29313870/aerobic-capacity-explains-physical-functioning-and-participation-in-patients-with-multiple-sclerosis-related-fatigue
#1
Emma Rosalie Driehuis, Lizanne Eva van den Akker, Vincent de Groot, Heleen Beckerman
OBJECTIVE: To investigate whether aerobic capacity explains the level of self-reported physical activity, physical functioning, and participation and autonomy in daily living in persons with multiple sclerosis-related fatigue. DESIGN: A cross-sectional study. PATIENTS: Sixty-two participants with multiple sclerosis-related fatigue. METHODS: Aerobic capacity was measured with a leg ergometer and was expressed as maximal oxygen uptake (VO2max, in ml/kg/min)...
January 9, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29313248/functional-outcomes-with-handsewn-versus-stapled-anastomoses-in-the-treatment-of-ultralow-rectal-cancer
#2
Lisa Ramage, Paul Mclean, Constantinos Simillis, Shengyang Qiu, Christos Kontovounisios, Emile Tan, Paris Tekkis
Adequate oncological outcomes have been demonstrated with rectal resection and handsewn coloanal anastomosis (CAA) in tumours in close proximity to the internal anal sphincter. Our aim was to assess functional differences between handsewn CAA and ultralow stapled anastomosis. Participants were identified from a single-surgeon series. Included participants underwent anorectal physiology testing of anal sphincter function, in addition to completion of several questionnaires: Wexner Incontinence Score (WIS); Birmingham Bowel, Bladder and Urinary Symptom Questionnaire (BBUSQ); Low Anterior Resection Syndrome (LARS) Score; SF36...
January 8, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29296845/depression-quality-of-life-and-medical-resource-utilization-in-sickle-cell-disease
#3
Soheir S Adam, Charlene M Flahiff, Shital Kamble, Marilyn J Telen, Shelby D Reed, Laura M De Castro
Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with SCD and its association with HRQoL and medical resource utilization. Depression was measured by the Beck Depression Inventory and clinical history in adult SCD outpatients at a comprehensive SCD center...
October 24, 2017: Blood Advances
https://www.readbyqxmd.com/read/29282099/the-focus-affinity-and-effects-trials-studying-the-effect-s-of-fluoxetine-in-patients-with-a-recent-stroke-statistical-and-health-economic-analysis-plan-for-the-trials-and-for-the-individual-patient-data-meta-analysis
#4
Catriona Graham, Steff Lewis, John Forbes, Gillian Mead, Maree L Hackett, Graeme J Hankey, John Gommans, Huy Thang Nguyen, Erik Lundström, Eva Isaksson, Per Näsman, Ann-Sofie Rudberg, Martin Dennis
BACKGROUND: Small trials have suggested that fluoxetine may improve neurological recovery from stroke. FOCUS, AFFINITY and EFFECTS are a family of investigator-led, multicentre, parallel group, randomised, placebo-controlled trials which aim to determine whether the routine administration of fluoxetine (20 mg daily) for six months after an acute stroke improves patients' functional outcome. METHODS/DESIGN: The core protocol for the three trials has been published (Mead et al...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29248779/decompression-alone-versus-decompression-and-fusion-for-lumbar-degenerative-spondylolisthesis-a-meta-analysis
#5
Zihao Chen, Peigen Xie, Feng Feng, Kishor Chhantyal, Yang Yang, Limin Rong
OBJECTIVE: To compare the effectiveness and safety of decompression alone (D group) with decompression and fusion (DF group) for patients who were diagnosed with lumbar degenerative spondylolisthesis (LDS). METHODS: Electronic databases were searched for relevant studies that compared decompression alone with decompression and fusion for LDS. Then data extraction and quality assessment were conducted, and the extracted data was analyzed by using RevMan 5.3. We used the random effects model for studies which had heterogeneity between them, and for those without heterogeneity, the fixed model was used...
December 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29207002/disability-fatigue-pain-and-their-associates-in-early-diffuse-cutaneous-systemic-sclerosis-the-european-scleroderma-observational-study
#6
Sébastien Peytrignet, Christopher P Denton, Mark Lunt, Roger Hesselstrand, Luc Mouthon, Alan Silman, Xiaoyan Pan, Edith Brown, László Czirják, Jörg H W Distler, Oliver Distler, Kim Fligelstone, William J Gregory, Rachel Ochiel, Madelon Vonk, Codrina Ancuta, Voon H Ong, Dominique Farge, Marie Hudson, Marco Matucci-Cerinic, Alexandra Balbir-Gurman, Øyvind Midtvedt, Alison C Jordan, Wendy Stevens, Pia Moinzadeh, Frances C Hall, Christian Agard, Marina E Anderson, Elisabeth Diot, Rajan Madhok, Mohammed Akil, Maya H Buch, Lorinda Chung, Nemanja Damjanov, Harsha Gunawardena, Peter Lanyon, Yasmeen Ahmad, Kuntal Chakravarty, Søren Jacobsen, Alexander J MacGregor, Neil McHugh, Ulf Müller-Ladner, Gabriela Riemekasten, Michael Becker, Janet Roddy, Patricia E Carreira, Anne Laure Fauchais, Eric Hachulla, Jennifer Hamilton, Murat Inanç, John S McLaren, Jacob M van Laar, Sanjay Pathare, Susanna Proudman, Anna Rudin, Joanne Sahhar, Brigitte Coppere, Christine Serratrice, Tom Sheeran, Douglas J Veale, Claire Grange, Georges-Selim Trad, Ariane L Herrick
Objectives: Our aim was to describe the burden of early dcSSc in terms of disability, fatigue and pain in the European Scleroderma Observational Study cohort, and to explore associated clinical features. Methods: Patients completed questionnaires at study entry, 12 and 24 months, including the HAQ disability index (HAQ-DI), the Cochin Hand Function Scale (CHFS), the Functional Assessment of Chronic Illness Therapy-fatigue and the Short Form 36 (SF36). Associates examined included the modified Rodnan skin score (mRSS), current digital ulcers and internal organ involvement...
November 30, 2017: Rheumatology
https://www.readbyqxmd.com/read/29206641/comparison-of-exercise-training-responses-in-copd-patients-with-and-without-alpha-1-antitrypsin-deficiency
#7
Inga Jarosch, Wolfgang Hitzl, Andreas Rembert Koczulla, Marion Wencker, Tobias Welte, Rainer Gloeckl, Sabina Janciauskiene, Klaus Kenn
BACKGROUND: The benefits of pulmonary rehabilitation (PR) on fatigue-resistant skeletal muscle fibre type I have been found to be smaller in COPD patients with alpha-1 antitrypsin deficiency (AATD) than in those without AATD. Alpha-1 antitrypsin (AAT) augmentation therapy was suggested as a potential factor of influence. Whether this finding mirrors different improvements in 6-min walk distance (6MWD) between both groups remains unknown. METHODS: 140 patients with AATD-related COPD (phenotype PiZZ, FEV1: 31 ± 8%pred...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29198673/pain-control-glucose-control-and-quality-of-life-in-patients-with-chronic-pancreatitis-after-total-pancreatectomy-with-islet-autotransplantation-a-preliminary-report
#8
J Solomina, J Gołębiewska, M R Kijek, A Kotukhov, P J Bachul, L Basto, K Gołąb, E Konsur, K Cieply, N Fillman, L-J Wang, C C Thomas, L H Philipson, M Tibudan, A Dębska-Ślizień, J Fung, A Gelrud, J B Matthews, P Witkowski
BACKGROUND: Total pancreatectomy (TP) is offered as a last treatment option for pain relief in patients with chronic pancreatitis. Concurrent islets autotransplantation (TP-IAT) may improve glucose control. METHODS: We analyzed results in 20 recent patients who underwent TP-IAT at The University of Chicago. The median observation period was 28 months (2-38). Data were collected prospectively then analyzed retrospectively. RESULTS: The number of patients requiring opioids daily for pain control decreased from 16 (80%) prior to surgery to 2 (13%) 1 year after, with only 1 (6...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29194531/conservative-surgery-versus-colorectal-resection-in-deep-endometriosis-infiltrating-the-rectum-a-randomized-trial
#9
Horace Roman, Michael Bubenheim, Emmanuel Huet, Valérie Bridoux, Chrysoula Zacharopoulou, Emile Daraï, Pierre Collinet, Jean-Jacques Tuech
STUDY QUESTION: Is there a difference in functional outcome between conservative versus radical rectal surgery in patients with large deep endometriosis infiltrating the rectum 2 years postoperatively? SUMMARY ANSWER: No evidence was found that functional outcomes differed when conservative surgery was compared to radical rectal surgery for deeply invasive endometriosis involving the bowel. WHAT IS KNOWN ALREADY: Adopting a conservative approach to the surgical management of deep endometriosis infiltrating the rectum, by employing shaving or disc excision, appears to yield improved digestive functional outcomes...
November 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29183306/acdf-vs-tdr-for-patients-with-cervical-spondylosis-an-8%C3%A2-year-follow-up-study
#10
Bolong Zheng, Dingjun Hao, Hua Guo, Baorong He
BACKGROUND: ACDF has been considered as the gold standard in the treatment of single level cervical disk protrusion. However, it may cause adjacent level degeneration due to regional biomechanical changes. TDR has been applied with satisfactory results for over a decade, but there is no consensus if TDR is safer and more efficient than ACDF. The current study was carried out to compare the efficiency and safety of TDR and ACDF in the treatment of patients with single level cervical disk protrusion...
November 28, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29157088/examining-the-effect-of-the-computer-based-educational-package-on-quality-of-life-and-severity-of-hypogonadism-symptoms-in-males
#11
Elahe Afsharnia, Minoo Pakgohar, Shahla Khosravi, Hamid Haghani
OBJECTIVE: The objective of this study was to determine the effect of the computer-based educational package on men's QoL and the severity of their hypogonadism symptoms. METHODS: A quasi-experimental study was conducted on 80 male employees. The data collection tool included the 'Aging Male Symptoms' (AMS) and 'Short Form-36' (SF36) questionnaires. Four sessions were held for the intervention group over a period of 4 weeks. Two months after training, QoL and the severity of hypogonadism symptoms were measured in both the intervention and control groups...
November 20, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29154811/a-systematic-review-highlights-the-need-to-investigate-the-content-validity-of-patient-reported-outcome-measures-for-physical-functioning-in-low-back-pain
#12
REVIEW
Alessandro Chiarotto, Raymond W Ostelo, Maarten Boers, Caroline B Terwee
OBJECTIVE: To summarize the evidence on content and structural validity of 17 patient-reported outcome measures (PROMs) to measure physical functioning in LBP. STUDY DESIGN AND SETTING: MEDLINE, EMBASE, CINAHL, PsycINFO, SportDiscus, and Google Scholar were searched (February 2017). Records on development, and studies assessing content validity or unidimensionality in patients with LBP were included. Two reviewers defined eligible studies and assessed their methodological quality with updated COSMIN standards...
November 14, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29148413/variable-impacts-of-different-remission-states-on-health-related-quality-of-life-in-rheumatoid-arthritis
#13
Margaret H Y Ma, Fowzia Ibrahim, Gabrielle H Kingsley, Andrew Cope, David L Scott
OBJECTIVES: Targeting remission in rheumatoid arthritis (RA) improves health-related quality of life (HRQoL) and disability. However, the impacts of different remission criteria and durations and their frequencies are uncertain. Our observational study assessed these factors. METHODS: We recruited RA patients with disease durations <10 years, stable suppressive therapies and stable disease activity scores for 28 joints using ESR (DAS28-ESR) ≤3.2. Intermittent and sustained remisisons were classified using DAS28ESR, simple disease activity index (SDAI) and ACR/EULAR Boolean criteria...
October 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29130655/-efficacy-of-sacroiliac-joint-anterior-approach-with-double-reconstruction-plate-and-computer-assisted-navigation-percutaneous-sacroiliac-screw-for-treating-tile-c1-pelvic-fractures
#14
Zhen Tan, Yue Fang, Hui Zhang, Lei Liu, Zhou Xiang, Gang Zhong, Fu-Guo Huang, Guang-Lin Wang
OBJECTIVE: To compare the efficacy of sacroiliac joint anterior approach with double reconstruction plate and computer assisted navigation percutaneous sacroiliac screw for treating Tile C1 pelvic fractures. METHODS: Fifty patients with pelvic Tile C1 fractures were randomly divided into two groups ( n=25 for each) in the orthopedic department of West China Hospital of Sichuan University from December 2012 to November 2014. Patients in group A were treated by sacroiliac joint dislocation with anterior plate fixation...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29117796/effects-of-varenicline-therapy-in-combination-with-advanced-behavioral-support-on-smoking-cessation-and-quality-of-life-in-inpatients-with-acute-exacerbation-of-copd-bronchial-asthma-or-community-acquired-pneumonia-a-prospective-open-label-preference-based
#15
Alexios Politis, Vasileios Ioannidis, Konstantinos I Gourgoulianis, Zoe Daniil, Chrissi Hatzoglou
Quitting smoking is the most important element in the therapeutic management of chronic respiratory diseases. Combining pharmacotherapy with behavioral support increases smoking cessation success rates. In addition, hospitalized smokers have increased motivation to quit. We investigated the efficacy on smoking cessation, of varenicline in combination with behavioral support, in smokers hospitalized due to (a) acute exacerbation of chronic obstructive pulmonary disease (COPD), or (b) bronchial asthma attack, or (c) community-acquired pneumonia (CAP)...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29104510/chronic-osteomyelitis-increases-the-incidence-of-type-2-diabetes-in-humans-and-mice
#16
Yicun Wang, Jun Wang, Zhantao Deng, Jiewen Jin, Hui Jiang, Jia Meng, Haidong Xu, Jianning Zhao, Guojing Sun, Hongbo Qian
Background: To compare the risk of type 2 diabetes (T2DM) between patients with and without chronic osteomyelitis (COM), both in humans and in mice, and to explore risk factors in COM patients who developed T2DM. Methods: One hundred seven patients with COM and 114 patients without COM were consecutively enrolled and retrospectively analysed. Clinical data concerning the time to develop diabetes, glucose metabolism, lipid metabolism, inflammatory factors, mental health and frequency of specialist visits were collected...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29100661/plating-for-midshaft-clavicular-fractures-the-impact-on-quality-of-life-and-functional-outcome
#17
Rens A van der Linde, Ivo Beetz, Sven H van Helden
INTRODUCTION: Several studies report on functional outcome after operative treatment for midshaft clavicular fractures. According to the published data not much is known about the quality of life after operative treatment. The purpose of this study is to investigate long term patient reported quality of life (QoL) and functional outcome after plating for midshaft clavicular fractures. METHODS: Patients between 16 and 65 years of age, with a midshaft clavicular fracture which were treated with plate fixation between 2006 and 2014, were included...
October 24, 2017: Injury
https://www.readbyqxmd.com/read/29042172/effect-of-upper-limb-rehabilitation-compared-to-no-upper-limb-rehabilitation-in-lung-transplant-recipients-a-randomized-controlled-trial
#18
L M Fuller, D El-Ansary, B M Button, M Corbett, G Snell, S Marasco, A E Holland
OBJECTIVE: to investigate effects of a supervised UL exercise program (SULP) versus no supervised UL exercise program (NULP) after lung transplantation (LTX). DESIGN: Randomized controlled trial SETTING: Physiotherapy gym PARTICIPANTS: Post LTX>18years, N=80 INTERVENTION: All participants underwent lower limb strength thrice weekly and endurance training. Participants randomised to supervised upper limb program (SULP) completed progressive UL strength training program using hand weights & adjustable pulley equipment...
October 14, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29037974/impact-of-early-unanticipated-revision-surgery-on-health-related-quality-of-life-after-adult-spinal-deformity
#19
Susana Núñez-Pereira, Alba Vila-Casademunt, Montse Domingo-Sàbat, Juan Bagó, Emre R Acaroglu, Ahmet Alanay, Ibrahim Obeid, Francisco Javier Sánchez Pérez-Grueso, Frank Kleinstück, Ferran Pellisé
Background context Revision surgery represents a major event for patients undergoing ASD surgery. Previous reports suggest minimal or no impact on HRQOL outcomes. Purpose To investigate the impact of early reoperations within the first year on health-related quality of life (HRQOL) and on the likelihood of reaching the MCID after ASD surgery. Design Retrospective analysis of prospectively collected data from consecutive surgically treated adult deformity surgery (ADS) patients included in a multicenter, international database...
October 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29025602/complex-tibial-plateau-fractures-a-retrospective-study-and-proposal-of-treatment-algorithm
#20
Amerigo Menghi, Giuseppe Mazzitelli, Emanuele Marzetti, Francesco Barberio, Emanuela D'Angelo, Giulio Maccauro
INTRODUCTION: Complex tibial plateau fractures are characterized by compression and sinking of one or both the articular surfaces. In this study, we evaluated clinical and radiological outcomes in patients with 41.C1,41.C2,41.C3 fractures according to AO classification. We also provide a specific therapeutic algorithm for each type of fracture. MATERIAL AND METHODS: The study was conducted in 43 patients who underwent surgical treatment for complex tibial plateau fractures and were followed for a minimum of 12 months...
October 2017: Injury
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