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https://www.readbyqxmd.com/read/29328007/-prophylactic-hydration-to-protect-renal-function-from-intravascular-iodinated-contrast-material-in-patients-at-high-risk-of-contrast-induced-nephropathy-amacing-a-prospective-randomised-phase-3-controlled-open-label-non-inferiority-trial
#1
E C Nijssen, R J Rennenberg, P J Nelemans, B A Essers, M M Janssen, M A Vermeeren, V van Ommen, J E Wildberger
BACKGROUND: Intravenous saline is recommended in clinical practice guidelines as the cornerstone for preventing contrast-induced nephropathy in patients with compromised renal function. However, clinical-effectiveness and cost-effectiveness of this prophylactic hydration treatment in protecting renal function has not been adequately studied in the population targeted by the guidelines, against a group receiving no prophylaxis. This was the aim of the AMACING trial. METHODS: AMACING is a prospective, randomised, phase 3, parallel-group, open-label, non-inferiority trial of patients at risk of contrast-induced nephropathy according to current guidelines...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29325575/routinely-collected-data-for-randomized-trials-promises-barriers-and-implications
#2
REVIEW
Kimberly A Mc Cord, Rustam Al-Shahi Salman, Shaun Treweek, Heidi Gardner, Daniel Strech, William Whiteley, John P A Ioannidis, Lars G Hemkens
BACKGROUND: Routinely collected health data (RCD) are increasingly used for randomized controlled trials (RCTs). This can provide three major benefits: increasing value through better feasibility (reducing costs, time, and resources), expanding the research agenda (performing trials for research questions otherwise not amenable to trials), and offering novel design and data collection options (e.g., point-of-care trials and other designs directly embedded in routine care). However, numerous hurdles and barriers must be considered pertaining to regulatory, ethical, and data aspects, as well as the costs of setting up the RCD infrastructure...
January 11, 2018: Trials
https://www.readbyqxmd.com/read/29323930/the-economic-burden-of-asthma-in-the-united-states-2008-2013
#3
Tursynbek Nurmagambetov, Robin Kuwahara, Paul Garbe
RATIONALE: Asthma is a chronic disease that affects quality of life, productivity at work and school, healthcare use, and can result in death. Measuring the current economic burden of asthma provides important information on the impact of asthma on society. This information can be used to make informed decisions about allocation of limited public health resources. OBJECTIVES: In this paper, we provide a comprehensive approach to estimate current prevalence, medical costs, cost of absenteeism (missed work and schooldays) and mortality attributable to asthma from a national perspective...
January 11, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29321853/tracking-plant-preference-for-higher-quality-mycorrhizal-symbionts-under-varying-co2-conditions-over-multiple-generations
#4
Gijsbert D A Werner, Yeling Zhou, Corné M J Pieterse, E Toby Kiers
The symbiosis between plants and root-colonizing arbuscular mycorrhizal (AM) fungi is one of the most ecologically important examples of interspecific cooperation in the world. AM fungi provide benefits to plants; in return plants allocate carbon resources to fungi, preferentially allocating more resources to higher-quality fungi. However, preferential allocations from plants to symbionts may vary with environmental context, particularly when resource availability affects the relative value of symbiotic services...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321628/realizing-mitigation-efficiency-of-european-commercial-forests-by-climate-smart-forestry
#5
Rasoul Yousefpour, Andrey Lessa Derci Augustynczik, Christopher P O Reyer, Petra Lasch-Born, Felicitas Suckow, Marc Hanewinkel
European temperate and boreal forests sequester up to 12% of Europe's annual carbon emissions. Forest carbon density can be manipulated through management to maximize its climate mitigation potential, and fast-growing tree species may contribute the most to Climate Smart Forestry (CSF) compared to slow-growing hardwoods. This type of CSF takes into account not only forest resource potentials in sequestering carbon, but also the economic impact of regional forest products and discounts both variables over time...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320343/healthcare-satisfaction-among-older-adults
#6
Hui P Liew
OBJECTIVE: This study seeks to examine how older adults rate and identify the importance of attributes associated with healthcare seeking and utilization (eg, affordability, type of facility, and accessibility) in the United States. METHODS: The empirical work of this cross-sectional study is based on the 2014 Health and Retirement Study. Conjoint analysis and cluster analysis are used to assess the objective. RESULTS: There is a pressing need for sound policies that seek to reduce the cost of treatment and consultation and to improve the accessibility of care facility for older adults even though satisfaction pertaining to these attributes (ie, affordability, type of facility, and accessibility) differs across clusters...
January 1, 2018: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29319456/comt-genotype-and-sensory-and-sensorimotor-gating-in-high-and-low-hypnotizable-subjects
#7
Zinaida I Storozheva, Anna V Kirenskaya, Mikhail N Gordeev, Maria E Kovaleva, Vladimir Yu Novototsky-Vlasov
We investigated the association between hypnotizability, COMT polymorphism, P50 suppression ratio, and prepulse inhibition of acoustic startle response (ASR) in 21 high (HH) and 19 low (LH) hypnotizable subjects. The frequency of Met/Met carriers of COMT polymorphysm was higher in HH than in LH group (33.3% versus 10.6%, p = .049). Increased ASR amplitude and latency and decreased prepulse inhibition at 120 ms lead interval were found in the HH compared to the LH group. The effect of COMT genotype on prepulse inhibition was observed in LH group only...
January 2018: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/29318828/-study-on-spatial-distribution-characteristics-of-traditional-chinese-medicine-resource-species-richness-based-on-national-census-of-chinese-medicine-resources-pilot
#8
Xiao-Bo Zhang, Hui Wang, Zhi-Xian Jing, Meng Li, Lan-Ping Guo, Lu-Qi Huang
Based on the data collected by the census team in the national census information management system, the spatial autocorrelation analysis method was used to analyze the similarity of the richness of Chinese herbal medicine resources in the investigated counties. The results showed that the species richness in the investigated counties appeared a tendency to focus on the distribution of the characteristics. Among them, the areas with sparse resources are concentrated in most areas of the north of the Yangtze River, northwest and most areas of Tibet...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29315783/nmr-based-approach-reveals-seasonal-metabolic-changes-in-mate-ilex-paraguariensis-a-st-hil
#9
Deisy Dos Santos Freitas, Wilian da Silva Nunes, Rafael do Prado Apparecido, Thiago Inácio Barros Lopes, Glaucia Braz Alcantara
Ilex paraguariensis (mate) is a species native to South America and is widely consumed in countries such Argentina, Uruguay, Paraguay and Brazil. Mate consumption is associated with several phytotherapeutic functions, in addition to its cultural and regional importance. However, the harvest period can affect the properties of the mate, due to variations in the constituent proportions, as a consequence of seasonal changes. In this work, we employed NMR and chemometrics to evaluate the chemical variations in leaf extracts of Ilex paraguariensis over the four seasons of the year...
January 6, 2018: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29315132/self-help-cognitive-behavior-therapy-for-working-women-with-problematic-hot-flushes-and-night-sweats-menos-work-a-multicenter-randomized-controlled-trial
#10
Claire Hardy, Amanda Griffiths, Sam Norton, Myra S Hunter
OBJECTIVE: The aim of the study was to examine the efficacy of an unguided, self-help cognitive behavior therapy (SH-CBT) booklet on hot flush and night sweat (HFNS) problem rating, delivered in a work setting. METHODS: Women aged 45 to 60 years, having 10 or more problematic HFNS a week, were recruited to a multicenter randomized controlled trial, via the occupational health/human resources departments of eight organizations. Participants were 1:1 randomized to SH-CBT or no treatment waitlist control (NTWC)...
January 8, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29314356/the-alcohol-environment-protocol-a-new-tool-for-alcohol-policy
#11
Sally Casswell, Neo Morojele, Petal Petersen Williams, Surasak Chaiyasong, Ross Gordon, Gaile Gray-Philip, Pham Viet Cuong, Anne-Marie MacKintosh, Sharon Halliday, Renee Railton, Steve Randerson, Charles D H Parry
INTRODUCTION AND AIM: To report data on the implementation of alcohol policies regarding availability and marketing, and drink driving, along with ratings of enforcement from two small high-income to three high-middle income countries, and one low-middle income country. METHOD: This study uses the Alcohol Environment Protocol, an International Alcohol Control study research tool, which documents the alcohol policy environment by standardised collection of data from administrative sources, observational studies and interviews with key informants to allow for cross-country comparison and change over time...
January 4, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29313906/respiratory-complications-of-anaesthesia
#12
REVIEW
G H Mills
Postoperative pulmonary complications are a major determinant of outcome for patients and consume huge resources within hospital, particularly in critical care. Prediction and anticipation of postoperative pulmonary complications are vital for patient selection and, in some cases, for informed patient consent. Being able to assess the likelihood of postoperative pulmonary complications also allows research into methods to reduce them by allowing allocation of patients to the appropriate arms of research trials...
January 2018: Anaesthesia
https://www.readbyqxmd.com/read/29313834/bidirectional-transport-model-of-morphogen-gradient-formation-via-cytonemes
#13
Paul C Bressloff, Hyunjoong Kim
Morphogen protein gradients play an important role in the spatial regulation of patterning during embryonic development. The most commonly accepted mechanism for gradient formation is diffusion from a source combined with degradation. Recently, there has been growing interest in an alternative mechanism, which is based on the direct delivery of morphogens along thin, actin-rich cellular extensions known as cytonemes. In this paper, we develop a bidirectional motor transport model for the flux of morphogens along cytonemes, linking a source cell to a one-dimensional array of target cells...
January 9, 2018: Physical Biology
https://www.readbyqxmd.com/read/29313430/the-assessment-and-sustainable-management-of-sickle-cell-disease-in-the-indigenous-tharu-population-of-nepal
#14
Miles Marchand, Carson Gill, Armaan K Malhotra, Carolyn Bell, Eric Busto, Monica D McKeown, Abhiram Cherukupalli, Jordan Yeo, Brendan Arnold, Videsh Kapoor
Sickle cell disease is an inherited hemoglobinopathy associated with significant morbidity and mortality. Reports suggest a high sickle cell disease burden among the indigenous Tharu population of Nepal, who for centuries have inhabited regions where malaria is endemic. Unfortunately, health care resources are limited and often inaccessible for Tharu individuals suffering from sickle cell disease. We conducted a large-scale screening effort to estimate the prevalence of Hb S (HBB: c.20A>T) among the Tharu population and delivered community-based education sessions to increase sickle cell disease awareness...
July 2017: Hemoglobin
https://www.readbyqxmd.com/read/29310683/exploring-multi-level-system-factors-facilitating-educator-training-and-implementation-of-evidence-based-practices-ebp-a-study-protocol
#15
Aubyn C Stahmer, Jessica Suhrheinrich, Patricia L Schetter, Elizabeth McGee Hassrick
BACKGROUND: This study examines how system-wide (i.e., region, district, and school) mechanisms such as leadership support, training requirements, structure, collaboration, and education affect the use of evidence-based practices (EBPs) in schools and how this affects the outcomes for students with autism spectrum disorder (ASD). Despite growing evidence for the positive effects of EBPs for ASD, these practices are not consistently or effectively used in schools. Although special education programs are mandated to use EBPs, there are very few evidence-based methods for selecting, implementing, and sustaining EBPs...
January 8, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29310654/pattern-and-determinants-of-contraceptive-usage-among-women-of-reproductive-age-from-the-digo-community-residing-in-kwale-kenya-results-from-a-cross-sectional-household-survey
#16
Vernon Mochache, Amyn Lakhani, Hajara El-Busaidy, Marleen Temmerman, Peter Gichangi
BACKGROUND: Contraceptive usage has been associated with improved maternal and child health (MCH) outcomes. Despite significant resources being allocated to programs, there has been sub-optimal uptake of contraception, especially in the developing world. It is important therefore, to granulate factors that determine uptake and utilization of contraceptive services so as to inform effective programming. METHODS: Between March and December 2015, we conducted a cross-sectional survey among women of reproductive age (WRA) from the Digo community residing in Kwale County, Kenya...
January 8, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29306863/implementation-of-medical-retina-virtual-clinics-in-a-tertiary-eye-care-referral-centre
#17
Karsten Kortuem, Katrin Fasler, Amanda Charnley, Hussain Khambati, Sandro Fasolo, Menachem Katz, Konstantinos Balaskas, Ranjan Rajendram, Robin Hamilton, Pearse A Keane, Dawn A Sim
BACKGROUND: The increasing incidence of medical retinal diseases has created capacity issues across UK. In this study, we describe the implementation and outcomes of virtual medical retina clinics (VMRCs) at Moorfields Eye Hospital, South Division, London. It represents a promising solution to ensure that patients are seen and treated in a timely fashion METHODS: First attendances in the VMRC (September 2016-May 2017) were included. It was open to non-urgent external referrals and to existing patients in a face-to-face clinic (F2FC)...
January 6, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29306806/transfers-of-embodied-pm2-5-emissions-from-and-to-the-north-china-region-based-on-a-multiregional-input-output-model
#18
Xue Yang, Wenzhong Zhang, Jie Fan, Jianhui Yu, Hongyan Zhao
Atmospheric PM2.5 pollution has become a global issue, and is increasingly being associated with social unrest. As a resource reliant local economy and heavy industry cluster, the North China region has become China's greatest emitter, and the source of much pollution spillover to outside regions. To address this issue, the current study investigates the transfers of embodied PM2.5 emissions to and from the North China region (which is taken to include Hebei, Henan, Shandong, and Shanxi, and is referred to here as HHSS)...
January 4, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29306374/challenges-in-mammography-education-and-training-today-the-perspectives-of-radiography-teachers-mentors-and-students-in-five-european-countries
#19
B Strøm, J A Pires Jorge, N Richli Meystre, A Henner, T Kukkes, E Metsälä, C Sà Dos Reis
INTRODUCTION: This study aims to explore current challenges in mammography education from the perspectives of radiography teachers, mentors and students. METHODS: A qualitative study including two focus groups interviews, with radiography teachers/mentors (n = 5) and student radiographers (n = 5) exploring their perspectives on challenges in mammography education today. The content analysis methodology proposed by Graneheim and Lundman was applied to the interviews...
February 2018: Radiography
https://www.readbyqxmd.com/read/29306189/effects-of-microcystis-aeruginosa-on-the-expression-of-nuclear-receptor-genes-in-daphnia-similoides-sinensis
#20
Xiaoxue Xu, Ya-Nan Zhang, Shuixiu Peng, Jianxun Wu, Daogui Deng, Zhongze Zhou
Nuclear receptor (NR) genes form a conserved superfamily, which is involved in organism metabolism, reproduction, development, homeostasis, and resource allocation. Microcystis aeruginosa can inhibit the growth and reproduction of Daphnia. However, whether M. aeruginosa can affect the expression of Daphnia NR genes is unknown. In total, 18 NRs were identified in this study based on previous Daphnia similoides sinensis transcriptome data. In treatments containing M. aeruginosa, the gene expression of the NR1 subfamily (E75a, E75b, HR3, HR96, NHR-1, HR97a, HR97g, and NHR97) and the NR2 subfamily (RXR, TLL, PNR, and SVP) were down-regulated 59% and 79%, respectively...
January 3, 2018: Ecotoxicology and Environmental Safety
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