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https://www.readbyqxmd.com/read/27929494/the-dosimetric-impact-of-control-point-spacing-for-sliding-gap-mlc-fields
#1
Benjamin J Zwan, Jonathan Hindmarsh, Erin Seymour, Kankean Kandasamy, Kirbie Sloan, Rajesakar David, Christopher Lee
Dynamic sliding gap multileaf collimator (MLC) fields are used to model MLC properties within the treatment planning system (TPS) for dynamic treatments. One of the key MLC properties in the Eclipse TPS is the dosimetric leaf gap (DLG) and precise determination of this parameter is paramount to ensuring accurate dose delivery. In this investigation, we report on how the spacing between control points (CPs) for sliding gap fields impacts the dose delivery, MLC positioning accuracy, and measurement of the DLG...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27928690/from-shoot-to-leaf-step-wise-shifts-in-meristem-and-knox1-activity-correlate-with-the-evolution-of-a-unifoliate-body-plan-in-gesneriaceae
#2
Kanae Nishii, Bing-Hong Huang, Chun-Neng Wang, Michael Möller
Typical dicots possess equal-sized cotyledons and leaf-bearing shoots topped with a shoot apical meristem (SAM), the source of lateral organs, and where KNOX1 homeobox genes act as key regulators. New World Gesneriaceae show typical cotyledons, whereas Old World Gesneriaceae show anisocotyly, the unequal post-germination growth of cotyledons, and include unifoliate (one-leaf) plants. One-leaf plants show an extremely reduced body plan: the adult above-ground photosynthetic tissue consisting of a single cotyledon, a macrocotyledon enlarged by the basal meristem (BM), but lacking a SAM...
December 8, 2016: Development Genes and Evolution
https://www.readbyqxmd.com/read/27923043/clonal-evolutionary-analysis-during-her2-blockade-in-her2-positive-inflammatory-breast-cancer-a-phase-ii-open-label-clinical-trial-of-afatinib-vinorelbine
#3
Gerald Goh, Ramona Schmid, Kelly Guiver, Wichit Arpornwirat, Imjai Chitapanarux, Vinod Ganju, Seock-Ah Im, Sung-Bae Kim, Arunee Dechaphunkul, Jedzada Maneechavakajorn, Neil Spector, Thomas Yau, Mehdi Afrit, Slim Ben Ahmed, Stephen R Johnston, Neil Gibson, Martina Uttenreuther-Fischer, Javier Herrero, Charles Swanton
BACKGROUND: Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer associated with HER2 amplification, with high risk of metastasis and an estimated median survival of 2.9 y. We performed an open-label, single-arm phase II clinical trial (ClinicalTrials.gov NCT01325428) to investigate the efficacy and safety of afatinib, an irreversible ErbB family inhibitor, alone and in combination with vinorelbine in patients with HER2-positive IBC. This trial included prospectively planned exome analysis before and after afatinib monotherapy...
December 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27917691/impact-a-multifaceted-implementation-for-conversation-partner-training-in-aphasia-in-dutch-rehabilitation-settings
#4
Sandra Wielaert, Mieke W M E van de Sandt-Koenderman, Nina Dammers, Karen Sage
PURPOSE: Exploration of the clinical uptake of a novel conversation partner training (CPT) programme in aphasia in 10 Dutch rehabilitation facilities and identification of its perceived facilitators and barriers in service providers, and the evaluation of the implementation methods used. METHOD: Ten rehabilitation centres took part in a multifaceted implementation of CPT over 13 months. Each centre selected two speech and language therapists to act as knowledge brokers whose role was to raise awareness of CPT in the team and to facilitate getting partners of people with aphasia into the programme...
December 5, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27917492/predictors-of-developing-mathematics-anxiety-among-middle-school-students-a-2-year-prospective-study
#5
Nir Madjar, Gil Zalsman, Abraham Weizman, Shaul Lev-Ran, Gal Shoval
While there is an abundance of research pertaining to the development of anxiety disorders, there is still a dearth of knowledge regarding the development of anxiety in the general population. The objective of this study was to longitudinally explore the development of mathematics anxiety among normative middle-school students, and to identify the moderating role of gender, school transition and scholastic achievements on these trajectories. Subjects included 413 sixth grade students (53.3% females, mean age 11...
December 4, 2016: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/27915065/assessment-of-white-matter-transgression-during-neuroendoscopic-procedures-using-dti-fiber-tracking
#6
Sergio García, Jordina Rincon-Torroella, Arnau Benet, Laura Oleaga, José Juan González Sánchez
BACKGROUND: Presurgical planning allows anticipating intraoperative difficulties, increasing efficiency, and reducing risks. Neuroendoscopy is a minimally invasive technique whose related complications have been focused on cortical function and surface vessels injury. However, white matter disruption has been insufficiently acknowledged. OBJECTIVE: To present a new surgical planning method based on diffusion tensor image that allows quantifying subcortical transgression and optimizing neuroendoscopic trajectories...
November 30, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27909659/reliability-of-the-planned-pedicle-screw-trajectory-versus-the-actual-pedicle-screw-trajectory-using-intra-operative-3d-ct-and-image-guidance
#7
Catherine A Miller, Charles G Ledonio, Matthew A Hunt, Farhan Siddiq, David W Polly
BACKGROUND: Technological advances, including navigation, have been made to improve safety and accuracy of pedicle screw fixation. We evaluated the accuracy of the virtual screw placement (Stealth projection) compared to actual screw placement (intra-operative O-Arm) and examined for differences based on the distance from the reference frame. METHODS: A retrospective evaluation of prospectively collected data was conducted from January 2013 to September 2013. We evaluated thoracic and lumbosacral pedicle screws placed using intraoperative O-arm and Stealth navigation by obtaining virtual screw projections and intraoperative O-arm images after screw placement...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27903757/beyond-hand-hygiene-a-qualitative-study-of-the-everyday-work-of-preventing-cross-contamination-on-hospital-wards
#8
Su-Yin Hor, Claire Hooker, Rick Iedema, Mary Wyer, Gwendolyn L Gilbert, Christine Jorm, Matthew Vincent Neil O'Sullivan
BACKGROUND: Hospital-acquired infections are the most common adverse event for inpatients worldwide. Efforts to prevent microbial cross-contamination currently focus on hand hygiene and use of personal protective equipment (PPE), with variable success. Better understanding is needed of infection prevention and control (IPC) in routine clinical practice. METHODS: We report on an interventionist video-reflexive ethnography study that explored how healthcare workers performed IPC in three wards in two hospitals in New South Wales, Australia: an intensive care unit and two general surgical wards...
November 30, 2016: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27903754/trajectories-to-seeking-demedicalised-assistance-in-suicide-a-qualitative-in-depth-interview-study
#9
Martijn Hagens, Bregje D Onwuteaka-Philipsen, H Roeline W Pasman
BACKGROUND: In the Netherlands, people can receive (limited) demedicalised assistance in suicide (DAS)-an option less well known than physician-assisted dying (PAD). AIM: This study explores which trajectories people take to seek DAS, through open-coding and inductive analysis of in-depth interviews with 17 people who receive(d) DAS from counsellors facilitated by foundation De Einder. RESULTS: People sought DAS as a result of current suffering or as a result of anticipating possible prospective suffering...
November 30, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27890749/the-medial-and-lateral-lemnisci-anatomically-adjoined-but-functionally-distinct-fiber-tracts
#10
Ruben Rodríguez-Mena, Uğur Türe
OBJECTIVE: The dense and complex distribution of neural structures in the brain stem makes it challenging to understand their real configuration. We used the fiber microdissection technique to reveal the course of the medial and lateral lemnisci within the brain stem. Although these structures seem anatomically alike, they are functionally distinct. METHODS: Fifteen human brain stems and eight brain hemispheres (formalin-fixed and previously frozen) were dissected and studied under the operating microscope by applying the fiber microdissection technique...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27888978/vulnerability-stress-and-support-in-the-disease-trajectory-from-prodrome-to-diagnosed-schizophrenia-diathesis-stress-support-model
#11
REVIEW
Sunny Chieh Cheng, Elaine Walsh, Karen G Schepp
Schizophrenia is a debilitating psychiatric disorder seen across the world. The goal of current research is to provide a more comprehensive understanding of prodrome, the initial period before the disease manifests as schizophrenia. Unfortunately, there is little information to comprehensively understand the indicators that later lead to schizophrenia. This has resulted in a lack of scientific knowledge to aid in early identification and intervention by psychiatric nurses or school nurses. Such information could inform nursing assessment and care plan development...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27886995/cosmic-radiation-exposure-of-future-hypersonic-flight-missions
#12
L Koops
Cosmic radiation exposure in air traffic grows with flight altitude, geographical latitude and flight time. For future high-speed intercontinental point-to-point travel, the trade-off between reduced flight time and enhanced dose rate at higher flight altitudes is investigated. Various representative (partly) hypersonic cruise missions are considered and in dependence on solar activity the integral route dose is calculated for envisaged flight profiles and trajectories. Our results are compared to those for corresponding air connections served by present day subsonic airliners...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27886053/automated-urban-travel-interpretation-a-bottom-up-approach-for-trajectory-segmentation
#13
Rahul Deb Das, Stephan Winter
Understanding travel behavior is critical for an effective urban planning as well as for enabling various context-aware service provisions to support mobility as a service (MaaS). Both applications rely on the sensor traces generated by travellers' smartphones. These traces can be used to interpret travel modes, both for generating automated travel diaries as well as for real-time travel mode detection. Current approaches segment a trajectory by certain criteria, e.g., drop in speed. However, these criteria are heuristic, and, thus, existing approaches are subjective and involve significant vagueness and uncertainty in activity transitions in space and time...
November 23, 2016: Sensors
https://www.readbyqxmd.com/read/27874977/relationship-between-age-and-trajectories-of-rehospitalization-risk-in-older-adults
#14
Kumar Dharmarajan, Angela Hsieh, Rachel P Dreyer, Jack Welsh, Li Qin, Harlan M Krumholz
OBJECTIVES: To characterize the magnitude and duration of risk of rehospitalization according to age after hospitalization for heart failure (HF), acute myocardial infarction (AMI), or pneumonia. DESIGN: Retrospective cohort study. SETTING: U.S. hospitals (n = 4,767). PARTICIPANTS: All Medicare fee-for-service beneficiaries aged 65 and older surviving hospitalization for HF, AMI, or pneumonia between October 2012 and December 2013...
November 22, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27862619/when-does-seed-limitation-matter-for-scaling-up-reforestation-from-patches-to-landscapes
#15
T Trevor Caughlin, Stephen Elliott, Jeremy W Lichstein
Restoring forest to hundreds of millions of hectares of degraded land has become a centerpiece of international plans to sequester carbon and conserve biodiversity. Forest landscape restoration will require scaling up ecological knowledge of secondary succession from small-scale field studies to predict forest recovery rates in heterogeneous landscapes. However, ecological field studies reveal widely divergent times to forest recovery, in part due to landscape features that are difficult to replicate in empirical studies...
December 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27861671/real-time-surgical-navigation-system-for-the-placement-of-zygomatic-implants-with-severe-bone-deficiency
#16
Kuofeng Hung, Wei Huang, Feng Wang, Yiqun Wu
This case report describes the clinical application of a real-time surgical navigation system to guide zygomatic implants on their placement. With the assistance of this novel navigation system, constant visualization of the drilling trajectory and exact control of the drilling direction can be achieved, which could minimize the risk of penetration into critical anatomical structures. Moreover, implants might be accurately placed in accordance to the preoperative planned position. In this patient, who had previously undergone a hemimaxillectomy, three zygomatic implants were placed on the unilateral zygoma, and two conventional implants were placed on the unresected maxilla...
November 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27848082/quantitative-analysis-of-the-trajectory-of-simulated-basilar-apex-aneurysms-through-the-internal-carotid-artery-to-assess-the-need-for-an-orbitozygomatic-approach
#17
Yasushi Motoyama, Yasuo Hironaka, Fumihiko Nishimura, Pritam Gurung, Ryota Sasaki, Yasuhiro Takeshima, Ryosuke Matsuda, Kentaro Tamura, Ichiro Nakagawa, Young-Su Park, Hiroyuki Nakase
BACKGROUND: The aim of this study was to identify the correlation between the location of the internal carotid artery (ICA) and the need for an orbitozygomatic approach (OZA) when approaching a basilar apex (BX) aneurysm. MATERIALS AND METHODS: By imaging the virtual trajectory to access the basilar artery (BA) through the ICA, the correlations among the height of the BX, the height and lateral breadth of the bifurcation of the ICA, and the need for removal of the orbital rim or zygomatic arch were investigated using three-dimensional computed tomography angiography (3DCTA) data of approximately 80 random samples not limited to BX aneurysms...
November 15, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27836232/trajectories-at-the-end-of-life-a-controlled-investigation-of-longitudinal-health-services-consumption-data
#18
Jiska Cohen-Mansfield, Shai Brill
BACKGROUND: Knowledge of individual-level trajectories of Health Services Consumption (HSC) at End-of-Life (EoL) is scarce. Such research is needed for understanding and planning health expenditures. OBJECTIVE: To explore individual-level EoL trajectories in the Israeli population. This approach differs from past studies which aggregated across populations or disease groups. DATA SOURCES: We used HMO (Health Maintenance Organization) longitudinal data for HSC of persons ages 65-90 who died during 2010-2011 (n=35,887) and of an age by sex matched sample of persons who were alive by mid-2012 (n=48,560)...
December 2016: Health Policy
https://www.readbyqxmd.com/read/27834803/advance-care-planning-in-glioblastoma-patients
#19
REVIEW
Lara Fritz, Linda Dirven, Jaap C Reijneveld, Johan A F Koekkoek, Anne M Stiggelbout, H Roeline W Pasman, Martin J B Taphoorn
Despite multimodal treatment with surgery, radiotherapy and chemotherapy, glioblastoma is an incurable disease with a poor prognosis. During the disease course, glioblastoma patients may experience progressive neurological deficits, symptoms of increased intracranial pressure such as drowsiness and headache, incontinence, seizures and progressive cognitive dysfunction. These patients not only have cancer, but also a progressive brain disease. This may seriously interfere with their ability to make their own decisions regarding treatment...
November 8, 2016: Cancers
https://www.readbyqxmd.com/read/27833537/forward-prediction-in-the-posterior-parietal-cortex-and-dynamic-brain-machine-interface
#20
He Cui
While remarkable progress has been made in brain-machine interfaces (BMIs) over the past two decades, it is still difficult to utilize neural signals to drive artificial actuators to produce predictive movements in response to dynamic stimuli. In contrast to naturalistic limb movements largely based on forward planning, brain-controlled neuroprosthetics mainly rely on feedback without prior trajectory formation. As an important sensorimotor interface integrating multisensory inputs and efference copy, the posterior parietal cortex (PPC) might play a proactive role in predictive motor control...
2016: Frontiers in Integrative Neuroscience
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