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https://www.readbyqxmd.com/read/29346116/4d-computed-tomography-scans-for-conformal-thoracic-treatment-planning-is-a-single-scan-sufficient-to-capture-thoracic-tumor-motion
#1
Yolanda D Tseng, Landon Wootton, Matthew Nyflot, Smith Apisarnthanarax, Ramesh Rengan, Charles Bloch, George Sandison, Sara St James
Four dimensional computed tomography (4DCT) scans are routinely used in radiation therapy to determine the internal treatment volume for targets that are moving (e.g. lung tumors). The use of these studies has allowed clinicians to create target volumes based upon the motion of the tumor during the imaging study. The purpose of this work is to determine if a target volume based on a single 4DCT scan at simulation is sufficient to capture thoracic motion. Phantom studies were performed to determine expected differences between volumes contoured on 4DCT scans and those on the evaluation CT scans (slow scans)...
January 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29339335/potential-impacts-of-offshore-oil-spills-on-polar-bears-in-the-chukchi-sea
#2
Ryan R Wilson, Craig Perham, Deborah P French-McCay, Richard Balouskus
Sea ice decline is anticipated to increase human access to the Arctic Ocean allowing for offshore oil and gas development in once inaccessible areas. Given the potential negative consequences of an oil spill on marine wildlife populations in the Arctic, it is important to understand the magnitude of impact a large spill could have on wildlife to inform response planning efforts. In this study we simulated oil spills that released 25,000 barrels of oil for 30 days in autumn originating from two sites in the Chukchi Sea (one in Russia and one in the U...
January 12, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29337830/exploring-the-effects-of-playing-formations-on-tactical-behaviour-and-external-workload-during-football-small-sided-games
#3
Jorge Baptista, Bruno Travassos, Bruno Gonçalves, Paulo Mourão, João L Viana, Jaime Sampaio
This study aimed to identify the effects of playing formations on tactical behaviour and external workload during football small-sided games. Twenty-three semi-professional footballers integrated three different playing formations in a 7-a-side small-sided game, according to their specific player positions: team 4:3:0 (4 defenders, 3 midfielders); team 4:1:2 (4 defenders, 1 midfielder, 2 forwards); and team 0:4:3 (4 midfielders, 3 forwards). Based on players' movement trajectories, the following individual and collective tactical variables were calculated: total distance covered and distance covered while walking, jogging, running and sprinting, distance from each player to both own and opponent's team centroid (Dist CG and Dist OPP CG, respectively), individual area, team length, team width and surface area...
January 4, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29337170/virtual-cerebral-aneurysm-clipping-with-real-time-haptic-force-feedback-in-neurosurgical-education
#4
Matthias Gmeiner, Johannes Dirnberger, Wolfgang Fenz, Maria Gollwitzer, Gabriele Wurm, Johannes Trenkler, Andreas Gruber
OBJECTIVE: Realistic, safe and efficient modalities for simulation-based training are highly warranted to enhance the quality of surgical education and should be incorporated in resident training. The aim of this study was to develop a patient-specific virtual cerebral aneurysm-clipping simulator with haptic force-feedback and real-time deformation of the aneurysm and vessels. METHODS: A prototype simulator was developed from 2012-2016. Evaluation of virtual clipping by blood flow simulation was integrated in this software and the prototype was evaluated by 18 neurosurgeons...
January 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29337012/expanding-the-limits-of-endoscopic-intraorbital-tumor-resection-using-3-dimensional-reconstruction
#5
Luciano Lobato Gregorio, Nicolas Y Busaba, Marcel M Miyake, Suzanne K Freitag, Benjamin S Bleier
INTRODUCTION: Endoscopic orbital surgery is a nascent field and new tools are required to assist with surgical planning and to ascertain the limits of the tumor resectability. OBJECTIVE: We purpose to utilize three-dimensional radiographic reconstruction to define the theoretical lateral limit of endoscopic resectability of primary orbital tumors and to apply these boundary conditions to surgical cases. METHODS: A three-dimensional orbital model was rendered in 4 representative patients presenting with primary orbital tumors using OsiriX open source imaging software...
December 26, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29336348/optimizing-highly-noncoplanar-vmat-trajectories-the-novo-method
#6
Marco Langhans, Jan Unkelbach, Thomas Bortfeld, David Craft
We introduce a new method called NoVo (Noncoplanar VMAT Optimization) to produce volumetric modulated arc therapy (VMAT) treatment plans with noncoplanar trajectories. While the use of noncoplanar beam arrangements for intensity modulated radiation therapy (IMRT), and in particular high fraction stereotactic radiosurgery (SRS), is common, noncoplanar beam trajectories for VMAT are less common as the availability of treatment machines handling these is limited. For both IMRT and VMAT, the beam angle selection problem is highly nonconvex in nature, which is why automated beam angle selection procedures have not entered mainstream clinical usage...
January 16, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29334802/youth-and-young-adults-with-acquired-brain-injury-transition-towards-work-related-roles-a-qualitative-study
#7
Alicia Paniccia, Heather Colquhoun, Bonnie Kirsh, Sally Lindsay
PURPOSE: The purpose of this research was to explore the experiences of youth and young adults with acquired brain injury as they transition towards work-related roles. Little is known about employment experiences among this age group. Understanding their perspectives can inform programs and clinical practice. MATERIALS AND METHODS: A descriptive qualitative design, including semi-structured interviews with 14 participants (8 females; 6 males) was used. Interviews were transcribed verbatim and analyzed using an open-coding, thematic approach...
January 15, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29330634/corrective-osteotomies-using-patient-specific-3d-printed-guides-a-critical-appraisal
#8
Wouter Rosseels, Michiel Herteleer, An Sermon, Stefaan Nijs, Harm Hoekstra
INTRODUCTION: Over the last decade, the technique of 3D planning has found its way into trauma surgery. The use of this technique in corrective osteotomies for treatment of malunions provides the trauma surgeon with a powerful tool. However, this technique is not entirely straightforward. We aimed to define potential pitfalls of this technique and possible solutions to overcome these shortcomings. MATERIALS AND METHODS: Ten patients with either a uni-, bi- or triplanar malunion of the long bones were included in this study...
January 12, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29329511/classifying-and-characterizing-the-development-of-adaptive-behavior-in-a-naturalistic-longitudinal-study-of-young-children-with-autism
#9
Cristan Farmer, Lauren Swineford, Susan E Swedo, Audrey Thurm
BACKGROUND: Adaptive behavior, or the ability to function independently in ones' environment, is a key phenotypic construct in autism spectrum disorder (ASD). Few studies of the development of adaptive behavior during preschool to school-age are available, though existing data demonstrate that the degree of ability and impairment associated with ASD, and how it manifests over time, is heterogeneous. Growth mixture models are a statistical technique that can help parse this heterogeneity in trajectories...
January 5, 2018: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/29326274/social-place-cells-in-the-bat-hippocampus
#10
David B Omer, Shir R Maimon, Liora Las, Nachum Ulanovsky
Social animals have to know the spatial positions of conspecifics. However, it is unknown how the position of others is represented in the brain. We designed a spatial observational-learning task, in which an observer bat mimicked a demonstrator bat while we recorded hippocampal dorsal-CA1 neurons from the observer bat. A neuronal subpopulation represented the position of the other bat, in allocentric coordinates. About half of these "social place-cells" represented also the observer's own position-that is, were place cells...
January 12, 2018: Science
https://www.readbyqxmd.com/read/29325763/clinical-experience-with-three-dimensional-printing-techniques-in-orthopedic-trauma
#11
Ji Wan Kim, Yongkoo Lee, Joonho Seo, Jai Hyung Park, Yong Min Seo, Sung Soo Kim, Hyun Chul Shon
BACKGROUND: To report our experiences with the use of three-dimensional (3D) printing in the field of orthopedic trauma. METHODS: This retrospective study enrolled 24 patients from three university teaching hospitals in whom 3D printing technique was applied: 14 patients with acetabular fractures and 10 patients with clavicular shaft fractures. We summarized our experiences with 3D printed bone models. RESULTS: Three-dimensional printed acetabular models improved understanding of complex acetabular anatomy and fracture pattern to plan the optimal positioning of a reduction clamp and the trajectory of screws...
January 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29320475/warfare-and-wildlife-declines-in-africa-s-protected-areas
#12
Joshua H Daskin, Robert M Pringle
Large-mammal populations are ecological linchpins, and their worldwide decline and extinction disrupts many ecosystem functions and services. Reversal of this trend will require an understanding of the determinants of population decline, to enable more accurate predictions of when and where collapses will occur and to guide the development of effective conservation and restoration policies. Many correlates of large-mammal declines are known, including low reproductive rates, overhunting, and habitat destruction...
January 10, 2018: Nature
https://www.readbyqxmd.com/read/29316618/trajectories-of-emotional-symptoms-and-peer-relationship-problems-in-children-after-nuclear-disaster-evidence-from-the-fukushima-health-management-survey
#13
Misari Oe, Masaharu Maeda, Tetsuya Ohira, Shuntaro Itagaki, Mayumi Harigane, Yuriko Suzuki, Hirooki Yabe, Seiji Yasumura, Kenji Kamiya, Hitoshi Ohto
The Fukushima Daiichi Nuclear Power Plant accident, which occurred in March 2011, is having long-term effects on children. We planned this study to describe the trajectories of emotional symptoms and peer relationship problems in children and to examine potential risks and protective factors over the 35 months following the accident. The sample was 11,791 children in the first to sixth elementary grades. We identified four patterns for emotional symptoms and three patterns for peer relationship problems, using group-based trajectory modelling...
January 6, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29316421/the-role-of-hippocampal-replay-in-memory-and%C3%A2-planning
#14
REVIEW
H Freyja Ólafsdóttir, Daniel Bush, Caswell Barry
The mammalian hippocampus is important for normal memory function, particularly memory for places and events. Place cells, neurons within the hippocampus that have spatial receptive fields, represent information about an animal's position. During periods of rest, but also during active task engagement, place cells spontaneously recapitulate past trajectories. Such 'replay' has been proposed as a mechanism necessary for a range of neurobiological functions, including systems memory consolidation, recall and spatial working memory, navigational planning, and reinforcement learning...
January 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29314470/needs-and-preferences-among-patients-with-high-grade-glioma-and-their-caregivers-a-longitudinal-mixed-methods-study
#15
K Piil, J Jakobsen, K B Christensen, M Juhler, T C Guetterman, M D Fetters, M Jarden
Previous reports on the patient perspective of daily life during a 1-year high-grade glioma (HGG) trajectory from the time of diagnosis are sparse. The aim of this longitudinal mixed methods study is to identify the specific needs and preferences for rehabilitation and supportive care and how it links with physical activity, psychological measures and health quality longitudinally over the first year after diagnosis among patients with HGG and their caregivers by integrating qualitative and quantitative findings...
January 4, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29313129/characteristics-and-care-pathways-of-advanced-cancer-patients-in-a-palliative-supportive-care-unit-and-an-oncological-ward
#16
Sebastiano Mercadante, Paolo Marchetti, Claudio Adile, Amanda Caruselli, Patrizia Ferrera, Andrea Costanzi, Alessandra Casuccio
BACKGROUND: A supportive palliative care unit (SPCU) may have a positive impact on patients' care. The aim of this study was to compare the pattern of patients admitted to a specialized SPCU and to a traditional oncologic ward (OW) in a consecutive sample of advanced cancer patients. METHODS: Data on patients demographics, reasons for and kind of admission, care-giver, anticancer treatments, being on/off treatment or uncertain, origin setting, who proposed hospital admission, the use of opioids, and hospitalization were gathered...
January 8, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29301480/made-in-denmark-scientific-mobilities-and-the-place-of-pedagogy-in-global-health
#17
Branwyn Poleykett
Transnational Global Health programmes planned and financed in the North and executed in the Global South usually involve some transfer of capacity between sites or capacity building in place. Capacity investment in the form of skills, knowledge, experience and equipment is often assumed to 'flow' between countries, laboratories and institutions, following the trajectories of mobile subjects in the knowledge economy. Drawing on in-depth interviews with Danish and East African scientists, this paper considers the mobilities that underpin scientific capacity building, drawing attention to the paradoxical in ways in which these programmes produce stasis and fixity, as well as mobility and exchange...
January 5, 2018: Global Public Health
https://www.readbyqxmd.com/read/29298400/exploring-opportunities-for-primary-outpatient-palliative-care-for-adults-with-cystic-fibrosis-a-mixed-methods-study-of-patients-needs
#18
Mara R Hobler, Ruth A Engelberg, J Randall Curtis, Kathleen J Ramos, Miriam I Zander, Shacole S Howard, Christopher H Goss, Moira L Aitken
BACKGROUND: Persons with cystic fibrosis (CF) experience high morbidity and mortality, yet little is known about their palliative care needs and how clinicians may address these needs. OBJECTIVES: (1) To identify palliative care and advance care planning needs of patients with CF and their families; and (2) to identify clinicians' potential roles in meeting these needs. METHODS: A mixed-methods study of adult patients (age ≥18 years) with moderate-to-severe CF [forced expiratory volume in the first second (FEV1) <65% predicted] were recruited from a CF Center...
January 3, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29289729/replacing-amalgam-with-a-high-viscosity-glass-ionomer-in-restoring-primary-teeth-a-cost-effectiveness-study-in-brasilia-brazil
#19
A Goldman, J E Frencken, R G De Amorim, S C Leal
OBJECTIVES: When planning primary oral health care services the cost implications of adopting new intervention practices are important, especially in resource-strapped countries. Although on a trajectory to be phased-out, amalgam remains the standard of care in many countries. METHODS: Adopting a government perspective, this study compared the costs of performing amalgam and ART/high-viscosity glass-ionomer cement (HVGIC) restorations and the consequences of failed restorations over 3 years in suburban Brasilia, Brazil...
December 28, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29288394/endoscopic-transorbital-route-to-the-petrous-apex-a-feasibility-anatomic-study
#20
Alberto Di Somma, Norberto Andaluz, Luigi Maria Cavallo, Thomaz E Topczewski, Federico Frio, Rosa Maria Gerardi, Jose Pineda, Domenico Solari, Joaquim Enseñat, Alberto Prats-Galino, Paolo Cappabianca
BACKGROUND: While the subtemporal approach represents the surgical module milestone designed to reach the petrous apex, a novel ventral route, which is the superior eyelid endoscopic transorbital approach, has been proposed to access the skull base. Accordingly, we aimed to evaluate the feasibility of this route to the petrous apex, providing a qualitative and quantitative analysis of this relatively novel pathway. METHODS: Five human cadaveric heads were dissected at the Laboratory of Surgical NeuroAnatomy of the University of Barcelona...
December 29, 2017: Acta Neurochirurgica
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