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https://www.readbyqxmd.com/read/26221407/advantages-of-an-etiology-based-method-for-treating-cancer-pain-a-case-report-and-literature-review
#1
Xiaojia Wang, Yu Li, Bangxiang Yang
UNLABELLED: The WHO analgesic guidelines for treatment of cancer pain have been proven safe and effective for most patients. However, there is still inadequate analgesia following that guideline based on pain degree. CASE REPORT: An 82-year-old man with history of right ceruminous gland carcinoma was treated by tumor resection following numerous courses of chemotherapy. He developed progressive pain ranging from 4 to 8 or 9 on the 0-10 numeric rating scale (NRS) involving the right side of face and neck area...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25362810/biopharmaceutical-evaluation-of-new-slow-release-tablets-obtained-by-hot-tableting-of-coated-pellets-with-tramadol-hydrochloride
#2
Danuta Szkutnik-Fiedler, Wiesław Sawicki, Monika Balcerkiewicz, Jarosław Mazgalski, Tomasz Grabowski, Edmund Grześkowiak
This study was aimed at a biopharmaceutical evaluation of a new oral dosage form of tramadol hydrochloride (TH)--slow release tablets obtained by hot tableting of coated pellets, 100 mg (TP), compared to the conventional slow release tablets, Tramal Retard, 100 mg (TR). Both TP and TR formulations showed a similar release profile of TH (f2 was 71) in in vitro release studies. The in vivo study was a two-treatment, two-period, two-sequence, single-oral dose 100 mg, crossover design using rabbit model with the phases separated by a washout period of 14 days...
September 2014: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/25265827/in-vitro-in-vivo-evaluation-of-a-new-oral-dosage-form-of-tramadol-hydrochloride-controlled-release-capsules-filled-with-coated-pellets
#3
COMPARATIVE STUDY
Danuta Szkutnik-Fiedler, Monika Balcerkiewicz, Wiesław Sawicki, Tomasz Grabowski, Edmund Grześkowiak, Jarosław Mazgalski, Hanna Urjasz
The aim of this study was an in vitro - in vivo evaluation of a new oral dosage form of tramadol hydrochloride (TH), controlled-release capsules filled with coated pellets, 100 mg (TC), compared to the sustained release tablets, Tramal Retard, 100 mg (TR). In vitro release study of both formulations showed a similar release profile of TH over 8 h (f2 was 52). In vivo study (single oral, 100 mg dose administration in 8 rabbits) showed that the amount of TH absorbed into the systemic circulation after TC and TR administration was also similar (90% CI for AUC(0-t) and AUC(0-infinity) were 90-124% and 97-109%, respectively)...
May 2014: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/24257391/the-effectiveness-of-pudendal-nerve-block-versus-caudal-block-anesthesia-for-hypospadias-in-children
#4
RANDOMIZED CONTROLLED TRIAL
Zoher M Naja, Fouad M Ziade, Raymond Kamel, Sabah El-Kayali, Nabil Daoud, Mariam A El-Rajab
BACKGROUND: Caudal block (CB) has some disadvantages, one of which is its short duration of action after a single injection. For hypospadias repair, pudendal nerve block (PNB) might be a suitable alternative since it has been successfully used for analgesia for circumcision. We evaluated PNB compared with CB as measured by total analgesic consumption 24 hours postoperatively. METHODS: In this prospective, double-blinded study, patients were randomized into 2 groups, either receiving CB or nerve stimulator-guided PNB...
December 2013: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/23343476/preoperative-pain-treatment-in-acute-abdomen-in-osogbo-nigeria-a-randomized-double-blind-placebo-controlled-study
#5
Olayide Agodirin, Adetunji Oguntola, Moses Adeoti, Austin Agbakwuru, Kehinde Oluwadiya, Babatunde Olofinbiyi
UNLABELLED: HASH(0x4d622a0) BACKGROUND: Withholding analgesics in acute abdomen for fear of masking clinical features and impairing diagnosis and decision-making is still being practiced despite recent evidence to the contrary. This study assesses the effect of preoperative analgesia on clinical findings, clinical diagnosis, and decision-making in patients with non-trauma acute abdomen. METHOD: This is a randomized, double-blind, placebo-controlled study using Tramal, a brand of tramadol, at the ED of LAUTECH Teaching Hospital Osogbo, Nigeria...
2013: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/23233504/phylogeny-and-taxonomy-of-the-recently-proposed-genus-phellinopsis-hymenochaetales-basidiomycota
#6
Li-Wei Zhou, Wen-Min Qin
Phellinopsis, a recently proposed genus, differs from other genera in Hymenochaetaceae in having setae arising from tramal hyphae and hyaline basidiospores that become pale yellowish with age. The monophyly of 11 taxa, including seven from China, was strongly supported in our phylogeny of ITS sequences. Two species, Phellinopsis junipericola and P. resupinata, are newly described and illustrated from Chinese specimens based on morphological and phylogenetic evidence, bringing the number of known Phellinopsis species worldwide to four...
May 2013: Mycologia
https://www.readbyqxmd.com/read/21510062/-supraclavicular-block-during-elbow-joint-surgeries-in-children
#7
O Iu Kadnikov, L N Morozova, S M Stepanenko
The regional methods of analgesia are the "golden standard" of choice during trauma surgeries. The supraclavicular block of the bracheal plexus is the method of choice during the cubital joint surgeries. The purpose of the study is to improve the effectiveness of anesthesia and postoperative analgesia for surgical interventions on the cubital joint in children by developing and implementing the clinical practice of peripheral blockade of the brachial plexus by the supraclavicular access. The study included 40 children aged 5 to 12 years...
January 2011: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/21478640/-pharmacological-profiles-and-clinical-roles-of-tramadol-hydrochloride-tramal-%C3%A2-capsules-25-mg%C3%A2-50-mg-in-the-treatment-of-cancer-pain
#8
REVIEW
Masaaki Hirouchi, Mamiko Tanaka, Takeshi Nishimura
No abstract text is available yet for this article.
April 2011: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/21387781/-structure-of-psychoactive-substances-determined-in-medical-toxicology-laboratory
#9
Ewa Gomółka, Krzysztof Łabuz, Tomasz Gawlikowski
Laboratory of Analytical Toxicology and Drug Monitoring, Jagiellonian University Medical College in Kraków performs analysis for patients from Kraków and south-east Poland. The determinations are made for intoxicated patients treated in the Toxicology Ward, for addicted patients treated in Detoxification Unit and other hospitals. The most often determined compounds are psychoactive substances (ethanol, drugs of abuse, psychotropic medicines). The purpose of the paper was to study structure of positive results of some psychoactive substances within seven years...
2010: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/19797937/clinical-equivalence-of-controlled-release-oxycodone-20-mg-and-controlled-release-tramadol-200-mg-after-surgery-for-breast-cancer
#10
RANDOMIZED CONTROLLED TRIAL
Sandra Kampe, Karsten Wolter, Mathias Warm, Oguzhan Dagtekin, Sasan Shaheen, Susanne Landwehr
AIMS: To assess clinical equivalence of 20 mg controlled-release oxycodone (Oxygesic; Mundipharma, Limburg, Germany) and 200 mg controlled-release tramadol (Tramal long; Grunenthal, Aachen, Germany) on a 12-hour dosing schedule in a randomized, double-blinded study of 54 ASA I-III physical status (American Society of Anesthesiologists classification of physical status) patients undergoing surgery for breast cancer. METHODS: General anesthesia using remifentanil and propofol was performed for surgery...
2009: Pharmacology
https://www.readbyqxmd.com/read/19102243/-multimodal-approach-to-postoperative-analgesia-in-patients-with-neuropathic-pain
#11
A P Nikolaev, V V Nikoda, V A Svetlov
Chronic neuropathic pain syndrome observed prior to surgery not only influences the intensity of pain, but also reduces the efficiency of selective use of analgesics. The purpose of the investigation was to study the efficiency of various analgesics and their combinations after lumbar microdiskectomy. Seventy-six patients who had undergone lumbar microdiskectomy and who suffered from chronic back pain were examined. According to the mode of postoperative analgesia, the patients were divided into 4 groups: 1) 20 patients received i...
September 2008: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/18199022/efficacy-of-arnica-montana-d4-for-healing-of-wounds-after-hallux-valgus-surgery-compared-to-diclofenac
#12
RANDOMIZED CONTROLLED TRIAL
Jens-Hagen Karow, Hans-Peter Abt, Markus Fröhling, Hanns Ackermann
OBJECTIVE: This study was undertaken to answer the question: "Is Arnica D4 as efficacious as diclofenac in relation to symptoms and wound healing after foot surgery?" METHODS: In this randomized double-blinded, parallel-group study (GCP-standard), the efficacy of Arnica D4 10 pillules (taken orally, 3 times per day) and diclofenac sodium, 50 mg (taken orally, 3 times per day) were investigated for equivalence in 88 patients 4 days after hallux valgus surgery. Outcome parameters were (1) postoperative irritation, (2) patient mobility, (3) rated pain, and (4) use of analgesics...
January 2008: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/17642138/-treatment-of-pain-in-patients-after-tonsillectomy
#13
COMPARATIVE STUDY
Olaf Zagólski, Jan Kulisiewicz, Marek Bernaś, Jerzy Kekuś
The aim of the study was to evaluate post-operative pain in patients after tonsillectomy, treated with non-steroid anti-inflammatory and opioid drugs. A group of 57 patients aged from 16 to 53 years was examined. 32 of them were treated with ketoprofen (Ketonal, Lek) in a dose 100 mg, 3 times a day and the remaining 25 with tramadol hydrochloride (Tramal) in daily doses 150-200 mg. The numerical 0 to 10 (VAS) and 6-grade verbal scales were used to assess pain intensity. Pain intensity was highest 3-4 days after tonsillectomy...
2006: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/17042229/adequacy-of-pain-relief-in-closed-manipulative-reduction-of-fracture-and-dislocation
#14
C H Wan Hazmy, S Hana Maizuliana, M T Mastura, M Norazlina
Adequate pain relief is a requisite for a successful closed manipulative reduction (CMR) of fractures and dislocations. This prospective study was undertaken to assess the mode and adequacy of pain relief given to patients undergoing such procedures at Seremban Hospital from the 1st April to the 31st May 2001. All patients with fractures and dislocations scheduled to undergo CMR were included in this study. The type of sedative agents and analgesia administered were recorded. Demographic data and the type of fracture or dislocation of the selected patients were documented...
February 2006: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/16995434/-comparative-analysis-of-antiarrhythmic-and-proarrhythmogenic-effects-of-drugs-for-neuroleptanalgesia-ataralgesia-and-antidepranalgesia-in-experimental-acute-myocardial-infarction
#15
COMPARATIVE STUDY
A M Iakushev, M P Iakushev, A V Sapozhkov
Proarrhythmogenic and antiarrhythmic effects of drugs for neuroleptanalgesia (NLA), ataralgesic (ATA) and antidepranalgesia (ADA) in chronic experiments on sleepless rabbits with acute myocardial infarction, with and without tachyarrhythmias, were studied using ECG, intraventricular electromanometry and tetropolar rheography. NLA (phentanylum, 1 microg/kg + droperidol, 5 microg/kg), ADA (pyrazidole, 1 mg/kg + tramal, 1 mg/kg) and ATA (diazepam, 1 mg/kg + promedol 0.5 mg/kg) produce antiarrhythmic effect with maximum manifestation of NLA on the 3rd day, and of ATA and ADA on 3-5th day...
July 2006: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/16715713/-proton-irradiation-of-the-pituitary-gland-for-alleviating-pain-in-patients-with-disseminated-prostate-cancer
#16
B V Kondrat'ev, V M Vinogradov, R A Shalek, N N Ialynych, M V Kopaneva
Central Research Institute of Roentgeno-Radiology; Medical Academy for Further Education, St. Petersburg Stereotactic ablation of the frontal lobe of the pituitary with narrow beams of 1,000 MeV protons was performed in 80 patients to alleviate pain caused by bone metastases. Pain was aborted for a long time so that pain-relieving medication was suspended in 56 (70%) patients. The remaining patients cut down on taking analgetics: peripheral drugs were taken by 11(13.75%), non-narcotic opioids (tramal)--4 (5%), class III opioid narcotics--7 (8...
2006: Voprosy Onkologii
https://www.readbyqxmd.com/read/15668743/the-role-of-tramadol-in-cancer-pain-treatment-a-review
#17
REVIEW
Wojciech Leppert, Jacek Łuczak
In most cancer patients pain can be successfully treated with pharmacological measures using opioid analgesics alone or in combination with adjuvant analgesics (coanalgesics). Weak opioids are usually recommended in the treatment of moderate cancer pain. There is still a debate as to whether the second step of the WHO analgesic ladder comprising opioid analgesics such as tramadol, codeine, dihydrocodeine, and dextropropoxyphene is still needed for the treatment of cancer pain. On the basis of our experience and review of the literature we think that there is definitely a place for weak opioids in the treatment of moderate cancer pain...
January 2005: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/15073888/bladder-dysfunction-during-the-use-of-tramadol
#18
R H Meyboom, C C Brodie-Meijer, W L Diemont, E P van Puijenbroek
The Netherlands Pharmacovigilance Foundation LAREB received five case reports concerning transient impairment of micturition or urinary retention, suspected to be induced by tramadol. In all patients--three women and two men--the symptoms occurred in temporal association with the use of tramadol and promptly recovered after stopping of the drug. Tramadol was taken orally in doses within the recommended therapeutic range (150 mg or less daily). Disturbance of micturition is not mentioned as a side-effect in the summary of product characteristics of Tramal 50 and 100...
April 1999: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/12918216/three-week-open-multi-centre-study-of-sustained-release-tramadol-in-various-pain-conditions
#19
MULTICENTER STUDY
Bozidar Curković, Natasa Bernik
UNLABELLED: 299 outpatients were included in this open multi-centre 3-week study of the efficacy and safety of sustained-release tramadol (CAS 27203-92-5, Tramal retard), in various pain conditions. Tramadol was administered 2 x 100 mg daily without prior introduction using an immediate release formula of the drug or titration of the dose. Of the 299 outpatients that were the subject of this study, 177 patients suffered from musculoskeletal pain, 58 from malignant pain and 44 suffered from postoperative pain, all treated by a total of 57 medical doctors of various profiles...
2003: Arzneimittel-Forschung
https://www.readbyqxmd.com/read/12696449/-postoperative-analgesia-with-tramal-in-newborn-children-using-the-method-of-continuous-intravenous-infusion
#20
V A Mikhel'son, Iu V Zhirkova, I D Beliaeva, S M Stepanenko, A F Manerova, O Iu Butyleva
The purpose of the study was to evaluate the efficiency of postoperative analgesia with tramal in the newborns. Analgesia with tramal (5% solution for injections, "Gruonental GmbH", Germany) was administered postoperatively in 20 newborn children. Thirteen children were operated for congenital malformations in the gastrointestinal and urinary tracts, three children were operated for purulent-septic diseases and four children were operated for neoplasms. Hemodynamics indices, i.e. heart rate (HR) and arterial pressure, as well as SaO2, respiratory rate (RR), acid-base condition and behavioral reactions were assessed...
January 2003: Anesteziologiia i Reanimatologiia
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