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Peripheral artery disease

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https://www.readbyqxmd.com/read/29912783/impact-of-serum-lipoprotein-a-on-endothelium-dependent-coronary-vasomotor-response-assessed-by-intracoronary-acetylcholine-provocation
#1
Ahmed Mashaly, Seung-Woon Rha, Byoung G Choi, Man J Baek, Yang G Ryu, Se Y Choi, Jae K Byun, Kareem Abdelshafi, Yoonjee Park, Won Y Jang, Kim Woohyeun, Eun J Park, Jah Yeon Choi, Jin O Na, Cheol U Choi, Hong E Lim, Eung J Kim, Chang G Park, Hong S Seo
BACKGROUND: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic vascular disease. However, there are limited data regarding the impact of Lp(a) levels on the incidence and severity of endothelium-dependent coronary vasomotor response. PATIENTS AND METHODS: A total of 2416 patients without significant coronary artery lesion (<50% stenosis) by coronary angiography and underwent acetylcholine (ACh) provocation test were enrolled and categorized according to their serum Lp(a) level into four quartile groups: less than 6...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29912673/end-organ-dysfunction-in-peripheral-arterial-disease-it-is-all-about-the-skeletal-muscle-microvasculature
#2
Xin Li, Sasan Partovi
No abstract text is available yet for this article.
June 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29910052/incidence-timing-and-type-of-first-and-recurrent-ischemic-events-in-patients-with-and-without-peripheral-artery-disease-after-an-acute-coronary-syndrome
#3
Taku Inohara, Karen Pieper, Daniel M Wojdyla, Manesh R Patel, William Schuyler Jones, Pierluigi Tricoci, Kenneth W Mahaffey, Stefan K James, John H Alexander, Renato D Lopes, Lars Wallentin, Erik Magnus Ohman, Matthew T Roe, Sreekanth Vemulapalli
BACKGROUND: Patients with peripheral artery disease (PAD) are known to have an increased risk of ischemic cardiovascular events. However, the influence of concomitant PAD on first and subsequent recurrent ischemic events after an acute coronary syndrome (ACS) remains poorly characterized. METHODS: We analyzed the combined data set from 4 randomized trials (PLATO, APPRAISE-2, TRA-CER, and TRILOGY ACS) in ACS for a follow-up length of 1 year. Using multivariable regression, we examined the association between PAD and major adverse cardiovascular events, a composite of cardiovascular death, myocardial infarction, and stroke...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29909087/critical-appraisal-of-the-quality-of-evidence-addressing-the-diagnosis-prognosis-and-management-of-peripheral-artery-disease-in-patients-with-diabetic-foot-ulceration
#4
Stephen R Ali, Baris A Ozdemir, Robert J Hinchliffe
AIMS: There is a paucity of robust evidence on prevention and management of diabetic foot ulcers (DFUs) to inform treatment. This study appraises the current quality of the evidence addressing diagnosis, prognosis, and management of peripheral artery disease (PAD) in patients with DFUs using a newly devised 21 point scoring (TOPS) disease specific research appraisal tool published by the International Working Group on the Diabetic Foot (IWGDF) and European Wound Management Association...
June 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29906223/new-mouse-model-of-pulmonary-hypertension-induced-by-respiratory-syncytial-virus-bronchiolitis
#5
Dai Kimura, Jordy Saravia, Sridhar Jaligama, Isabella McNamara, Luan D Vu, Ryan D Sullivan, Salvatore Mancarella, Dahui You, Stephania A Cormier
Pulmonary hypertension (PH) has been observed in up to 75% of infants with moderate to severe respiratory syncytial virus (RSV) bronchiolitis and is associated with significant morbidity and mortality in infants with congenital heart disease. The purpose of this study was to establish a mouse model of PH secondary to RSV bronchiolitis that mimics the disease etiology as it occurs in infants. Neonatal mice were infected with RSV at 5 days of age, and then re-infected 4 weeks later. Serum free medium was administered to age-matched mice as control...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29905414/tips-for-pedal-access-technical-evolution-and-review
#6
Ansar Z Vance, Daniel A Leung, Timothy W Clark
Pedal access has become an indispensable technique for endovascular therapy of complex lower extremity peripheral vascular disease. From an option as a single access in a patient lacking traditional access approaches to a critical maneuver in combined antegrade-retrograde approaches during the treatment of complex chronic total occlusions, pedal access is an essential tool for any endovascular physician treating peripheral arterial disease. Anticipatory planning is critical in the successful utilization of pedal access...
June 14, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29904448/extended-duration-dual-antiplatelet-therapy-after-percutaneous-coronary-intervention-in-patients-with-peripheral-arterial-disease-a-meta-analysis
#7
Hua Ling, Ebony Andrews, David Ombengi, Fang Li
Background: Patients with peripheral arterial disease (PAD) undergoing percutaneous coronary intervention (PCI) are at elevated risk of ischemic and bleeding events. However, the optimal duration of dual antiplatelet therapy (DAPT) after PCI in patients with PAD remains unclear. Methods: A systematic literature search was performed through June 2017 using PubMed, EMBASE and Cochrane databases with the following key terms: "dual antiplatelet therapy", "P2Y12 inhibitor", "myocardial infarction", "percutaneous coronary intervention", "stent", "peripheral arterial disease", and "ankle-brachial index"...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29903685/periodontal-disease-systemic-inflammation-and-the-risk-of-cardiovascular-disease
#8
REVIEW
Edgar Francisco Carrizales-Sepúlveda, Alejandro Ordaz-Farías, Raymundo Vera-Pineda, Ramiro Flores-Ramírez
Periodontal and cardiovascular disease are both major health issues. Poor oral health has long been associated with the development of systemic diseases, with the typical example being the risk of endocarditis posterior to dental procedures. Through the years, the association of periodontal disease with other non-infectious systemic diseases has been brought to attention. One of the most interesting associations is the one that exists with the development of cardiovascular disease. Many studies, including systematic reviews and meta-analyses, suggest an important association between periodontal disease and ischaemic heart disease, cerebrovascular disease, heart failure, atrial fibrillation and peripheral artery disease...
June 2, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29902701/risk-of-peripheral-artery-disease-according-to-a-healthy-lifestyle-score-the-predimed-study
#9
Nieves López-Laguna, Miguel A Martínez-González, Estefania Toledo, Nancy Babio, José V Sorlí, Emilio Ros, Miguel Ángel Muñoz, Ramon Estruch, José Lapetra, Carlos Muñoz-Bravo, Miquel Fiol, Lluís Serra-Majem, Xavier Pintó, José I González, Montse Fitó, Josep Basora, Fernando Arós, Miguel Ruiz-Canela
BACKGROUND AND AIMS: The PREDIMED (PREvención con DIeta MEDiterránea) is a multicentre trial analyzed as a prospective cohort study. A total of 7122 participants (aged 55-80 years) at high risk of cardiovascular disease in the PREDIMED trial were recruited in 11 centres in Spain. The prevalence of subjects with type 2 diabetes was 50%. Our objective was to determine the contribution of lifestyle factors to the development of peripheral artery disease (PAD). METHODS: Incident clinical PAD in relation to a healthy lifestyle 5-point score defined as adherence to a Mediterranean diet (MedDiet), moderate alcohol intake, regular physical activity, normal weight (BMI<25) and non-smoking was measured...
May 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29898836/impact-of-polyvascular-disease-on-patients-with-atrial-fibrillation-insights-from-rocket-af
#10
Sean T Chen, Anne S Hellkamp, Richard C Becker, Scott D Berkowitz, Günter Breithardt, Keith A A Fox, Werner Hacke, Jonathan L Halperin, Graeme J Hankey, Kenneth W Mahaffey, Christopher C Nessel, Jonathan P Piccini, Daniel E Singer, Manesh R Patel
BACKGROUND: We investigated the impact of polyvascular disease in patients enrolled in ROCKET AF. METHODS: Cox regression models were used to assess clinical outcomes and treatment effects of rivaroxaban compared with warfarin in patients with atrial fibrillation and coronary, peripheral, or carotid artery disease, or any combination of the 3. RESULTS: A total of 655 (4.6%) patients had polyvascular disease (≥2 disease locations), and 3,391 (23...
June 2018: American Heart Journal
https://www.readbyqxmd.com/read/29898825/improvement-of-the-quality-of-evidence-of-peripheral-artery-disease-in-diabetic-foot-ulceration-small-step-for-a-doctor-giant-leap-for-mankind
#11
Cornelis G Vos, Jean-Paul P M de Vries
No abstract text is available yet for this article.
June 10, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29898467/-peripheral-arterial-disease-trends-in-morbidity-and-mortality
#12
Nasser Malyar, Eva Freisinger, Holger Reinecke
No abstract text is available yet for this article.
June 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29897296/high-iliac-calcium-score-is-associated-with-increased-severity-and-complexity-of-peripheral-arterial-disease-and-predicts-global-atherosclerotic-burden
#13
Zsuzsanna Jeremias, Nora Rat, Imre Benedek, Emese Rapolti, Mihaela Ratiu, Adrian Muresan, Theodora Benedek
BACKGROUND: The role of vascular calcifications in iliac arteries for predicting global atherosclerotic burden in still unknown. The aim of this study was to investigate whether iliac calcium score (ICS), a new computed tomographic angiography (CTA) derived biomarker of vascular calcification, can predict the severity and complexity of peripheral arterial disease (PAD) as well as the global atherosclerotic burden. PATIENTS AND METHODS: This was a single centre, non-randomized, observational prospective study on 84 consecutive patients with symptomatic peripheral arterial disease, undergoing peripheral CTA examination of the lower limbs, divided into high (n = 42) and low ICS (n = 42) groups with a median value for ICS of 3934 HU...
June 13, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29897154/factors-associated-with-discontinuing-or-not-starting-oral-anticoagulant-therapy-in-older-hospitalized-patients-with-non-valvular-atrial-fibrillation
#14
Jesús Díez-Manglano, José-María Mostaza, Antonio Pose, Francesc Formiga, José-María Cepeda, Alejandra Gullón, Miguel Camafort, Jesús Castiella, Eduardo Rovira, Estíbaliz Jarauta, Carmen Suárez
AIM: To determine the factors associated with discontinuing or not starting oral anticoagulation (OA) therapy in older patients with non-valvular atrial fibrillation (NVAF). METHODS: A prospective, multicenter cohort study was carried out of patients aged >75 years with NVAF hospitalized in internal medicine departments in Spain. For each patient, we recorded creatinine, hemoglobin and platelets levels, as well as CHA2DS2-VASc and HAS-BLED scores and the Charlson Comorbidity Index...
June 13, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29896632/screening-for-cardiovascular-disease-risk-with-electrocardiography-us-preventive-services-task-force-recommendation-statement
#15
Susan J Curry, Alex H Krist, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Martha Kubik, C Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng, John B Wong
Importance: Cardiovascular disease (CVD), which encompasses atherosclerotic conditions such as coronary heart disease, cerebrovascular disease, and peripheral arterial disease, is the most common cause of death among adults in the United States. Treatment to prevent CVD events by modifying risk factors is currently informed by CVD risk assessment with tools such as the Framingham Risk Score or the Pooled Cohort Equations, which stratify individual risk to inform treatment decisions. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on screening for coronary heart disease with electrocardiography (ECG)...
June 12, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29896436/frailty-in-older-adults-with-cardiovascular-disease-cause-effect-or-both
#16
Emma Ef Kleipool, Emiel O Hoogendijk, Marijke C Trappenburg, M Louis Handoko, Martijn Huisman, Mike Jl Peters, Majon Muller
Cardiovascular disease (CVD) has been associated with an increased risk of frailty, but the direction of the association remains unclear. This study set out to examine the bidirectional longitudinal association between CVD and frailty over an extended period of time. Data are from 1432 older adults (aged 65-88yrs) of the Longitudinal Aging Study Amsterdam (LASA), who were followed for 17 years. At baseline and follow-up, CVD was assessed through self-report, medication use and medical records, and classified as angina pectoris, myocardial infarction, heart failure (HF), stroke, and peripheral artery disease...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896104/increased-atp-and-ado-overflow-from-sympathetic-nerve-endings-and-mesentery-endothelial-cells-plus-reduced-nitric-oxide-are-involved-in-diabetic-neurovascular-dysfunction
#17
M Verónica Donoso, M Jesús Mascayano, Inés M Poblete, J Pablo Huidobro-Toro
Since the mechanism of human diabetic peripheral neuropathy and vascular disease in type 1 diabetes mellitus remains unknown, we assessed whether sympathetic transmitter overflow is altered by this disease and associated to vascular dysfunction. Diabetes was induced by streptozotocin (STZ)-treatment and compared to vehicle-treated rats. Aliquots of the ex vivo perfused rat arterial mesenteric preparation, denuded of the endothelial layer, were collected to quantify analytically sympathetic nerve co-transmitters overflow secreted by the isolated mesenteries of both groups of rats...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29895816/combined-hyperbaric-oxygen-partial-pressure-at-1-4-bar-with-infrared-radiation-a-useful-tool-to-improve-tissue-hypoxemia
#18
Tobias Dünnwald, Julia Held, Petru Balan, Otto Pecher, Thomas Zeiger, Frank Hartig, Erich Mur, Günter Weiss, Wolfgang Schobersberger
Tissue hypoxia contributes to the pathogenesis of several acute and chronic diseases. Hyperbaric oxygen therapy (HBO) and whole-body warming using low-temperature infrared technology (LIT) are techniques that might improve hypoxemia. Combining HBO and LIT as hyperbaric oxygen therapy combined with low-temperature infrared radiation (HBOIR) might be an approach that results in positive synergistic effects on oxygenation. LIT increases blood flow and could reduce HBO-induced vasoconstriction, and hyperoxia could compensate for the increased metabolic oxygen requirements mediated by LIT...
June 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29894588/peripheral-artery-disease-how-do-genes-and-pharmacology-interplay
#19
EDITORIAL
Wassim Shatila, Zvonimir Krajcer
In patients with peripheral artery disease, high on-treatment platelet reactivity (HoTPR) might be associated with worse outcomes for those taking clopidogrel, but not for those taking aspirin. Certain genetic polymorphisms might account for HoTPR. Current literature supports the importance of antiplatelet therapy in treating patients with PAD with clopidogrel, aspirin, or both.
June 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29893152/ticagrelor-for-the-prevention-of-ischemic-events-in-patients-with-prior-myocardial-infarction-and-peripheral-artery-disease
#20
José C Nicolau, Luciano M Baracioli, Robert P Giugliano
Cardiovascular disease (CVD) is the main cause of death in the world. Coronary artery disease (CAD) is the most common form of CVD presentation, but the prevalence of peripheral artery disease (PAD) is increasing. Patients with polyvascular disease comprise a very high-risk population that has been infrequently studied. Areas covered: The authors review the current evidence of the efficacy and safety of ticagrelor in the setting of acute coronary syndrome and stable patients post-MI with and without PAD and summarize its pharmacokinetics, pharmacodynamics, and regulatory issues...
June 12, 2018: Expert Opinion on Pharmacotherapy
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