keyword
https://read.qxmd.com/read/38493415/causal-association-between-cardiovascular-proteins-and-membranous-nephropathy-a-bidirectional-mendelian-randomization
#1
JOURNAL ARTICLE
Qiqi Ma, Gaosi Xu
PURPOSE: Multiple circulating proteins have been reported to participate in human diseases. However, the association between cardiovascular proteins and membranous nephropathy (MN) remained profoundly elusive. METHODS: A bidirectional Mendelian randomization (MR) analysis was conducted to explore the causal correlation between ninety cardiovascular proteins and MN. Genome-wide association study (GWAS) data of cardiovascular proteins and MN were all from European research...
March 17, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38490477/ectoine-protects-corneal-epithelial-survival-and-barrier-from-hyperosmotic-stress-by-promoting-anti-inflammatory-cytokine-il-37
#2
JOURNAL ARTICLE
Jin-Miao Li, Na Lin, Yun Zhang, Xin Chen, Zhao Liu, Rong Lu, Fang Bian, Haixia Liu, Stephen C Pflugfelder, De-Quan Li
PURPOSE: To explore novel role and molecular mechanism of a natural osmoprotectant ectoine in protecting corneal epithelial cell survival and barrier from hyperosmotic stress. METHODS: Primary human corneal epithelial cells (HCECs) were established from donor limbus. The confluent cultures in isosmolar medium were switched to hyperosmotic media (400-500 mOsM), with or without ectoine or rhIL-37 for different time periods. Cell viability and proliferation were evaluated by MTT or WST assay...
March 13, 2024: Ocular Surface
https://read.qxmd.com/read/38490288/effects-of-viscum-coloratum-kom-nakai-on-collagen-induced-rheumatoid-arthritis
#3
JOURNAL ARTICLE
Yanfu Wang, Zhichao Hao, Dongxu Lu, Anam Naseem, Ye Sun, Yan Sun, Jianzhe Li, Haixue Kuang, Yan Liu, Bingyou Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Viscum coloratum (Kom.) Nakai has been traditionally used in China for nearly a thousand years to treat rheumatic diseases. However, its efficacy and mechanisms in treating rheumatoid arthritis (RA) have not been demonstrated. AIM OF THE STUDY: To investigate the anti-arthritic effects and molecular mechanisms of Viscum coloratum (Kom.) Nakai on collagen-induced arthritic mice through network pharmacology technology and experimental validation...
March 13, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38481989/cystatin-from-the-helminth-ascaris-lumbricoides-upregulates-mevalonate-and-cholesterol-biosynthesis-pathways-and-immunomodulatory-genes-in-human-monocyte-derived-dendritic-cells
#4
JOURNAL ARTICLE
Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R Williams, Luis Caraballo
BACKGROUND: Ascaris lumbricoides cystatin (Al-CPI) prevents the development of allergic airway inflammation and dextran-induced colitis in mice models. It has been suggested that helminth-derived cystatins inhibit cathepsins in dendritic cells (DC), but their immunomodulatory mechanisms are unclear. We aimed to analyze the transcriptional profile of human monocyte-derived DC (moDC) upon stimulation with Al-CPI to elucidate target genes and pathways of parasite immunomodulation. METHODS: moDC were generated from peripheral blood monocytes from six healthy human donors of Denmark, stimulated with 1 µM of Al-CPI, and cultured for 5 hours at 37°C...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38481326/cancer-cell-specific-and-pro-apoptotic-smac-peptide-doxorubicin-conjugated-prodrug-encapsulated-aposomes-for-synergistic-cancer-immunotherapy
#5
JOURNAL ARTICLE
Jinseong Kim, Man Kyu Shim, Yujeong Moon, Jeongrae Kim, Hanhee Cho, Wan Su Yun, Nayeon Shim, Joon-Kyung Seong, Yonghyun Lee, Dong-Kwon Lim, Kwangmeyung Kim
BACKGROUND: Immunogenic cell death (ICD) is a crucial approach to turn immunosuppressive tumor microenvironment (ITM) into immune-responsive milieu and improve the response rate of immune checkpoint blockade (ICB) therapy. However, cancer cells show resistance to ICD-inducing chemotherapeutic drugs, and non-specific toxicity of those drugs against immune cells reduce the immunotherapy efficiency. METHODS: Herein, we propose cancer cell-specific and pro-apoptotic liposomes (Aposomes) encapsulating second mitochondria-derived activator of caspases mimetic peptide (SMAC-P)-doxorubicin (DOX) conjugated prodrug to potentiate combinational ICB therapy with ICD...
March 13, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38479315/rutin-mitigates-fluoride-induced-nephrotoxicity-by-inhibiting-ros-mediated-lysosomal-membrane-permeabilization-and-the-gsdme-hmgb1-axis-involved-in-pyroptosis-and-inflammation
#6
JOURNAL ARTICLE
Yue Ma, Panpan Xu, Hengrui Xing, Yue Zhang, Tingting Li, Xueman Ding, Li Liu, Qiang Niu
Fluoride is known to induce nephrotoxicity; however, the underlying mechanisms remain incompletely understood. Therefore, this study aims to explore the roles and mechanisms of lysosomal membrane permeabilization (LMP) and the GSDME/HMGB1 axis in fluoride-induced nephrotoxicity and the protective effects of rutin. Rutin, a naturally occurring flavonoid compound known for its antioxidative and anti-inflammatory properties, is primarily mediated by inhibiting oxidative stress and reducing proinflammatory markers...
March 12, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38476910/fluorofenidone-attenuates-renal-fibrosis-by-inhibiting-lysosomal-cathepsin%C3%A2-mediated-nlrp3-inflammasome-activation
#7
JOURNAL ARTICLE
Linfeng Zheng, Wenjuan Mei, Jing Zhou, Xin Wei, Zhijuan Huang, Xiaozhen Lin, Li Zhang, Wei Liu, Qian Wu, Jinhong Li, Yan Yan
Currently, no antifibrotic drug in clinical use can effectively treat renal fibrosis. Fluorofenidone (AKFPD), a novel pyridone agent, significantly reduces renal fibrosis by inhibiting the activation of the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome; however, the underlying mechanism of this inhibition is not fully understood. The present study aimed to reveal the molecular mechanism underlying the suppression of NLRP3 inflammasome activation by AKFPD. It investigated the effect of AKFPD on NLRP3 activation and lysosomal cathepsins in a unilateral ureteral obstruction (UUO) rat model, and hypoxia/reoxygenation (H/R)-treated HK-2 cells and murine peritoneal-derived macrophages (PDMs) stimulated with lipopolysaccharide (LPS) and ATP...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38475576/transcriptome-analysis-of-meloidogyne-javanica-and-the-role-of-a-c-type-lectin-in-parasitism
#8
JOURNAL ARTICLE
Wenwei Chi, Lili Hu, Zhiwen Li, Borong Lin, Kan Zhuo, Jinling Liao
Meloidogyne javanica is one of the most widespread and economically important sedentary endoparasites. In this study, a comparative transcriptome analysis of M. javanica between pre-parasitic second-stage juveniles (Pre-J2) and parasitic juveniles (Par-J3/J4) was conducted. A total of 48,698 unigenes were obtained, of which 18,826 genes showed significant differences in expression ( p < 0.05). In the differentially expressed genes (DEGs) from transcriptome data at Par-J3/J4 and Pre-J2, a large number of unigenes were annotated to the C-type lectin (CTL, Mg01965 ), the cathepsin L-like protease ( Mi-cpl-1 ), the venom allergen-like protein ( Mi-mps-1 ), Map-1 and the cellulase (endo-β-1,4-glucanase)...
March 4, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38474630/targeted-library-of-phosphonic-type-inhibitors-of-human-neutrophil-elastase
#9
JOURNAL ARTICLE
Karolina Torzyk-Jurowska, Jaroslaw Ciekot, Lukasz Winiarski
Despite many years of research, human neutrophil elastase (HNE) still remains an area of interest for many researchers. This multifunctional representative of neutrophil serine proteases is one of the most destructive enzymes found in the human body which can degrade most of the extracellular matrix. Overexpression or dysregulation of HNE may lead to the development of several inflammatory diseases. Previously, we presented the HNE inhibitor with kinact /KI value over 2,000,000 [M-1 s-1 ]. In order to optimize its structure, over 100 novel tripeptidyl derivatives of α-aminoalkylphosphonate diaryl esters were synthesized, and their activity toward HNE was checked...
March 1, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38473070/morphological-and-molecular-changes-during-limb-regeneration-of-the-exopalaemon-carinicauda
#10
JOURNAL ARTICLE
Chaofan Xing, Mintao Wang, Zhenxiang Chen, Yong Li, Xinlei Zhou, Lei Wang, Yao Zhong, Wenjia Li, Xin Shen, Huan Gao, Panpan Wang
With the increase in breeding density of Exopalaemon carinicauda , appendage breakage may occur, which seriously affects survival and economic benefits. To study the limb regeneration process of E. carinicauda , we induced autotomy of the pereopods. After a period of time, wound swelling disappeared, the pigment gradually accumulated, and a tawny film subsequently formed in the wound. The healing period of the wound occurred 24 h after autotomy, and the blastema formation stage occurred 48 h after autotomy...
February 22, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38472852/characterization-of-the-effects-of-low-sodium-salt-substitution-on-sensory-quality-protein-oxidation-and-hydrolysis-of-air-dried-chicken-meat-and-its-molecular-mechanisms-based-on-tandem-mass-tagging-labeled-quantitative-proteomics
#11
JOURNAL ARTICLE
Jianhao Li, Zihang Shi, Xiankang Fan, Lihui Du, Qiang Xia, Changyu Zhou, Yangying Sun, Baocai Xu, Daodong Pan
The effects of low-sodium salt mixture substitution on the sensory quality, protein oxidation, and hydrolysis of air-dried chicken and its molecular mechanisms were investigated based on tandem mass tagging (TMT) quantitative proteomics. The composite salt formulated with 1.6% KCl, 0.8% MgCl2 , and 5.6% NaCl was found to improve the freshness and texture quality scores. Low-sodium salt mixture substitution significantly decreased the carbonyl content (1.52 nmol/mg), surface hydrophobicity (102.58 μg), and dimeric tyrosine content (2...
February 28, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38470488/neutrophil-proteases-are-protective-against-sars-cov-2-by-degrading-the-spike-protein-and-dampening-virus-mediated-inflammation
#12
JOURNAL ARTICLE
Nathan Gf Leborgne, Christelle Devisme, Nedim Kozarac, Inês Berenguer Veiga, Nadine Ebert, Aurélie Godel, Llorenç Grau-Roma, Melanie Scherer, Philippe Plattet, Volker Thiel, Gert Zimmer, Adriano Taddeo, Charaf Benarafa
Studies on severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have highlighted the crucial role of host proteases for viral replication and the immune response. The serine proteases furin and TMPRSS2 and lysosomal cysteine proteases were shown to facilitate virus entry by limited proteolytic processing of the spike (S) protein. While neutrophils are recruited to the lungs during COVID-19 pneumonia, little is known about the role of the neutrophil serine proteases (NSPs) cathepsin G (CatG), elastase (NE), and proteinase 3 (PR3) on SARS-CoV-2 entry and replication...
March 12, 2024: JCI Insight
https://read.qxmd.com/read/38463588/dysregulation-of-kidney-proteases-in-the-pathogenesis-of-hypertension-following-unilateral-nephrectomy-in-juvenile-mice
#13
JOURNAL ARTICLE
Rasha Aly, Yunus E Dogan, Niharika Bala, Carlos Lugo, Seena Darwish, Lawrence Shoemaker, Abdel A Alli
BACKGROUND: Unliteral nephrectomy (UNX) results in the reduction of kidney mass. The remaining kidney undergoes compensatory renal growth via hypertrophy of the glomeruli and renal tubules to maintain a normal glomerular filtration rate (GFR). These compensatory mechanisms result in increased capillary pressure and glomerular hyperfiltration to increase single nephron GFR. Over time, hyperfiltration may lead to kidney scarring and the development of hypertension. OBJECTIVES: The first objective of this study was to test the hypothesis that a 50% reduction in functioning nephrons in juvenile mice leads to increased blood pressure over a 24-hour phase...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38463572/plant-cathepsin-b-a-versatile-protease
#14
REVIEW
Marianna Coppola, Lukas Mach, Patrick Gallois
Plant proteases are essential enzymes that play key roles during crucial phases of plant life. Some proteases are mainly involved in general protein turnover and recycle amino acids for protein synthesis. Other proteases are involved in cell signalling, cleave specific substrates and are key players during important genetically controlled molecular processes. Cathepsin B is a cysteine protease that can do both because of its exopeptidase and endopeptidase activities. Animal cathepsin B has been investigated for many years, and much is known about its mode of action and substrate preferences, but much remains to be discovered about this potent protease in plants...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38462960/cathepsin-k-inhibition-alleviates-periodontal-bone-resorption-by-promoting-type-h-vessel-formation-through-pdgf-bb-pdgfr-%C3%AE-axis
#15
JOURNAL ARTICLE
Huan Zhou, Yi-Fan Zhang, Qian-Qian Zhang, Fen Liu, Jia-Yu Zhang, Yue Chen
OBJECTIVES: To explore the effects of cathepsin K (CTSK) inhibition on type H vessel formation and alveolar bone resorption within periodontitis. METHODS: Conditioned media derived from preosteoclasts pretreated with the CTSK inhibitor odanacatib (ODN), ODN supplemented small interfering RNA targeting PDGF-BB (si-PDGF-BB), or PBS were prepared, to assess their proangiogenic effects on endothelial cells (HUVECs). A series of angiogenic-related assays were conducted to evaluate HUVEC proliferation, migration, and tube formation abilities in vitro...
March 11, 2024: Oral Diseases
https://read.qxmd.com/read/38462197/reductive-stress-and-cytotoxicity-in-the-swollen-river-mussel-unio-tumidus-exposed-to-microplastics-and-salinomycin
#16
JOURNAL ARTICLE
Viktoria Martyniuk, Tetiana Matskiv, Kateryna Yunko, Vira Khoma, Lesya Gnatyshyna, Caterina Faggio, Oksana Stoliar
Multistress effects lead to unpredicted consequences in aquatic ecotoxicology and are extremely concerning. The goal of this study was to trace how specific effects of the antibiotic salinomycin (Sal) and microplastics (MP) on the bivalve molluscs are manifested in the combined environmentally relevant exposures. Unio tumidus specimens were treated with Sal (0.6 μg L-1 ), MP (1 mg L-1 , 2 μm size), and both at 18 °C (Mix) and 25 °C (MixT) for 14 days...
March 8, 2024: Environmental Pollution
https://read.qxmd.com/read/38461633/a-therapeutic-strategy-of-parthenolide-in-improving-imiquimod-induced-psoriasis-like-skin-inflammation-targeting-il-36-nets-through-skin-transdermal-therapeutic-system
#17
JOURNAL ARTICLE
Zi-Ying Zhan, Zhi-Hong Zhang, Rong-Hui Sun, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian
BACKGROUND: Psoriasis is an inflammatory skin disease that occurs repeatedly over time. The natural product of sesquiterpene lactones, Parthenolide (Par), is isolated from Tanacetum parthenium L. (feverfew) which has significant effects on anti-inflammatory. The therapeutic effect of the medication itself is crucial, but different routes of administration of the same drug can also produce different effects. PURPOSE: The aim of our research sought to investigate the ameliorating effects of Par in psoriasis-like skin inflammation and its related mechanism of action...
March 9, 2024: International Immunopharmacology
https://read.qxmd.com/read/38460807/toosendanin-induces-hepatotoxicity-by-restraining-autophagy-and-lysosomal-function-through-inhibiting-stat3-ctsc-axis
#18
JOURNAL ARTICLE
Li Luo, Jiajie Ni, Jiahui Zhang, Jinxian Lin, Sixin Chen, Feihai Shen, Zhiying Huang
Toosendanin (TSN) is the main active component in the traditional herb Melia toosendan Siebold & Zucc, which exhibits promising potential for development due to its diverse pharmacological properties. However, the hepatotoxicity associated with TSN needs further investigation. Previous research has implicated autophagy dysregulation in TSN-induced hepatotoxicity, yet the underlying mechanisms remain elusive. In this study, the mechanisms of signal transducer and activator of transcription 3 (STAT3) in TSN-induced autophagy inhibition and liver injury were explored using Stat3 knockout C57BL/6 mice and HepG2 cells...
March 7, 2024: Toxicology Letters
https://read.qxmd.com/read/38460801/cathepsin-b-as-a-key-regulator-of-ferroptosis-in-microglia-following-intracerebral-hemorrhage
#19
JOURNAL ARTICLE
Jinxin Lu, Haiying Li, Zhengquan Yu, Chang Cao, Zhongmou Xu, Lu Peng, John H Zhang, Gang Chen
Intracerebral hemorrhage (ICH) is a subtype of stroke marked by elevated mortality and disability rates. Recently, mounting evidence suggests a significant role of ferroptosis in the pathogenesis of ICH. Through a combination of bioinformatics analysis and basic experiments, our goal is to identify the primary cell types and key molecules implicated in ferroptosis post-ICH. This aims to propel the advancement of ferroptosis research, offering potential therapeutic targets for ICH treatment. Our study reveals pronounced ferroptosis in microglia and identifies the target gene, cathepsin B (Ctsb), by analyzing differentially expressed genes following ICH...
March 7, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38455371/microbiota-in-colorectal-cancer-related-to-liver-metastasis
#20
JOURNAL ARTICLE
Peijun Wei, Weiming Han, Zitong Zhang, Xue Tian, Chen Yang, Qiaoxuan Wang, Weihao Xie, Ying Liu, Yuanhong Gao, Hui Chang
The prevalence of colorectal cancer (CRC) is increasing annually and metastasis is the principal cause of death in patients with CRC, with the liver being the most frequently affected site. Many studies have shown a strong interplay between the gut flora, particularly Fusobacterium nucleatum ( F. nucleatum ), Escherichia coli , and Bacteroides fragilis , and the development of gut tumors. Some strains can induce gut inflammation and produce toxins that directly harm gut epithelial cells, ultimately accelerating the onset and progression of CRC...
February 29, 2024: Chinese Journal of Cancer Research
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