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https://www.readbyqxmd.com/read/29457487/dementia-management-strategies-associated-with-neuropsychiatric-symptoms-of-elderly-people-with-alzheimer-s-disease
#1
Lais Lopes Delfino, Ricardo Shoiti Komatsu, Caroline Komatsu, Anita Liberalesso Neri, Meire Cachioni
This study aims to investigate the association between management and communication strategies and the presence of neuropsychiatric symptoms presented by elderly people with Alzheimer's disease. One hundred and thirty-four family caregivers answered a questionnaire with socio-demographic data and questions regarding the care context, the Small Communication Strategies Scale, the Dementia Management Strategy Scale, and the Neuropsychiatric Inventory. Caregivers used the criticism management strategy more when the elderly presented hallucination, agitation, depression, anxiety, irritability, nighttime behavior, and appetite abnormalities...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29457214/maintenance-zinc-therapy-after-initial-penicillamine-chelation-to-treat-symptomatic-hepatic-wilson-s-disease-in-resource-constrained-setting
#2
Piyush Gupta, Mehul Choksi, Ashish Goel, Uday Zachariah, Kattiparambil Gangadharan Sajith, Jeyamani Ramachandran, George Chandy, George Kurian, Grace Rebekah, Chundamannil Eapen Eapen
BACKGROUND: Experience with zinc in treating symptomatic hepatic Wilson's disease (WD) is limited. AIM: To study the efficacy of Penicillamine followed by zinc in treating symptomatic hepatic Wilson's disease. METHODS: We retrospectively analyzed case records of 31 symptomatic hepatic WD patients for whom disease severity scores (Child's, model for end-stage liver disease (MELD), Nazer's, and New Wilson Index (NWI) score) and 24-h urinary copper were compared at 3-time points-baseline at presentation, at transition from penicillamine to zinc and at end of follow up...
February 19, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29456360/clinical-features-and-psychiatric-comorbidity-of-epicrania-fugax
#3
K Rammohan, M M Shyma, Soumitra Das, C Velayudhan Shaji
Background: Epicrania fugax (EF) is a rare newly described primary headache characterized by paroxysms of unilateral pain radiating across one hemicranium. Aim: We aimed to describe 10 new cases of EF and assess the psychiatric comorbidity. Materials and Methods: Cases of EF were identified from patients attending the neurology outpatient department of a tertiary level referral and teaching hospital by the first author during a period extending from January 1, 2015 to April 31, 2017...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29455177/nmdar-n-methyl-d-aspartate-receptor-encephalitis-in-a-patient-with-ms-multiple-sclerosis-a-rare-and-challenging-case
#4
Sadia Suleman, Qaiser Javed
We present a rare case of N-methyl-D-aspartate receptor (NMDAR) encephalitis in a 41-year-old Caucasian woman, who initially presented with prominent neuropsychiatric symptoms on the background of pre-existing multiple sclerosis. Here, the authors navigate the muddy water between neurology and psychiatry, describing the caveats of antibody testing with a misdiagnosed case of acute and transient psychotic episode. NMDAR encephalitis in MS is a rare condition, which can be easily confused with a new onset psychotic episode...
February 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29455081/quality-of-life-and-level-of-burden-in-primary-caregivers-of-patients-with-epilepsy-effect-of-neuropsychiatric-comorbidity
#5
Ana Maria Gutierrez-Angel, Iris Enriqueta Martinez-Juarez, Laura Elena Hernandez-Vanegas, Daniel Crail-Melendez
BACKGROUND: Few studies are focused on the quality of life (QOL) of primary caregivers and the effects of the clinical variables of epilepsy and patient psychiatric comorbidity on primary caregivers. PURPOSE: Our main objective was to describe QOL and level of burden (LB) in caregivers of people with epilepsy (PWE) at a tertiary-care hospital in Mexico City. A secondary purpose was to determine if LB and QOL were different between caregivers of patients with neuropsychiatric comorbidity and caregivers of patients without neuropsychiatric comorbidity...
February 15, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29454746/phosphodiesterase-inhibition-and-modulation-of-corticostriatal-and-hippocampal-circuits-clinical-overview-and-translational-considerations
#6
REVIEW
P R A Heckman, A Blokland, E P P Bollen, J Prickaerts
The corticostriatal and hippocampal circuits contribute to the neurobiological underpinnings of several neuropsychiatric disorders, including Alzheimer's disease, Parkinson's disease and schizophrenia. Based on biological function, these circuits can be clustered into motor circuits, associative/cognitive circuits and limbic circuits. Together, dysfunctions in these circuits produce the wide range of symptoms observed in related neuropsychiatric disorders. Intracellular signaling in these circuits is largely mediated through the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway with an additional role for the cyclic guanosine monophosphate (cGMP)/ protein kinase G (PKG) pathway, both of which can be regulated by phosphodiesterase inhibitors (PDE inhibitors)...
February 15, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29454353/genetics-of-the-human-y-chromosome-and-its-association-with-male-infertility
#7
REVIEW
Stacy Colaco, Deepak Modi
The human Y chromosome harbors genes that are responsible for testis development and also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y chromosome (Yq) contains many ampliconic and palindromic sequences making it predisposed to self-recombination during spermatogenesis and hence susceptible to intra-chromosomal deletions. Such deletions lead to copy number variation in genes of the Y chromosome resulting in male infertility. Three common Yq deletions that recur in infertile males are termed as AZF (Azoospermia Factor) microdeletions viz...
February 17, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29454305/psychotropic-and-anti-dementia-treatment-in-elderly-persons-with-clinical-signs-of-dementia-with-lewy-bodies-a-cross-sectional-study-in-40-nursing-homes-in-sweden
#8
Iris Zahirovic, Gustav Torisson, Carina Wattmo, Elisabet Londos
BACKGROUND: Elderly persons with a dementia diagnosis often suffer from different neuropsychiatric symptoms (NPS) such as delusions, hallucinations, depression, anxiety, irritability and agitation. Currently, the medical treatment for NPS consists mostly of psychotropic medication such as hypnotics/sedatives, anxiolytics and antipsychotics. In elderly persons with dementia, usage of antipsychotics is less appropriate because of the risk of side effects such as parkinsonism, rapid cognitive decline, cerebrovascular events and finally mortality...
February 17, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29453749/lifelong-robbery-victimisation-and-mental-disorders-at-age-18-years-brazilian-population-based-study
#9
Joseph Murray, Natália Peixoto Lima, Ana Carolina Oliveira Ruivo, Andrea Ramírez Varela, Caroline Cardozo Bortolotto, Elma Izze da Silva Magalhães, Franciéle Marabotti Costa Leite, Mariana Otero Xavier, Jean-Baptiste Pingault, Seena Fazel, Gregore Iven Mielke, Luciana Anselmi, Fernando César Wehrmeister, Helen Gonçalves, Ana Maria Baptista Menezes
PURPOSE: Urban violence is a major problem in Brazil and may contribute to mental disorders among victims. The aim of this study was to assess the association between robbery victimisation and mental health disorders in late adolescence. METHODS: At age 18 years, 4106 participants in the 1993 Pelotas Birth Cohort Study were assessed. A questionnaire about history of robbery victimisation was administered, the Self-Report Questionnaire was used to screen for common mental disorders, and the Mini International Neuropsychiatric Interview was used to assess major depressive disorder and generalised anxiety disorder...
February 17, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29453460/development-and-initial-characterization-of-a-novel-ghrelin-receptor-crispr-cas9-knockout-wistar-rat-model
#10
L J Zallar, B J Tunstall, C T Richie, Y J Zhang, Z B You, E L Gardner, M Heilig, J Pickel, G F Koob, L F Vendruscolo, B K Harvey, L Leggio
BACKGROUND/OBJECTIVES: Ghrelin, a stomach-derived hormone implicated in numerous behaviors including feeding, reward, stress, and addictive behaviors, acts by binding to the growth hormone secretagogue receptor (GHSR). Here, we present the development, verification, and initial characterization of a novel GHSR knockout (KO) Wistar rat model created with CRISPR genome editing. METHODS: Using CRISPR/Cas9, we developed a GHSR KO in a Wistar background. Loss of GHSR mRNA expression was histologically verified using RNAscope in wild-type (WT; n = 2) and KO (n = 2) rats...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29452685/behavioural-outcomes-of-subthalamic-stimulation-and-medical-therapy-versus-medical-therapy-alone-for-parkinson-s-disease-with-early-motor-complications-earlystim-trial-secondary-analysis-of-an-open-label-randomised-trial
#11
Eugénie Lhommée, Lars Wojtecki, Virginie Czernecki, Karsten Witt, Franziska Maier, Lisa Tonder, Lars Timmermann, Thomas D Hälbig, Fanny Pineau, Franck Durif, Tatiana Witjas, Marcus Pinsker, Maximilian Mehdorn, Friederike Sixel-Döring, Andreas Kupsch, Rejko Krüger, Saskia Elben, Stephan Chabardès, Stéphane Thobois, Christine Brefel-Courbon, Fabienne Ory-Magne, Jean-Marie Regis, David Maltête, Anne Sauvaget, Jörn Rau, Alfons Schnitzler, Michael Schüpbach, Carmen Schade-Brittinger, Gunther Deuschl, Jean-Luc Houeto, Paul Krack
BACKGROUND: Although subthalamic stimulation is a recognised treatment for motor complications in Parkinson's disease, reports on behavioural outcomes are controversial, which represents a major challenge when counselling candidates for subthalamic stimulation. We aimed to assess changes in behaviour in patients with Parkinson's disease receiving combined treatment with subthalamic stimulation and medical therapy over a 2-year follow-up period as compared with the behavioural evolution under medical therapy alone...
March 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29452684/evaluation-of-the-safety-tolerability-and-efficacy-of-pimavanserin-versus-placebo-in-patients-with-alzheimer-s-disease-psychosis-a-phase-2-randomised-placebo-controlled-double-blind-study
#12
Clive Ballard, Carol Banister, Zunera Khan, Jeffrey Cummings, George Demos, Bruce Coate, James M Youakim, Randall Owen, Srdjan Stankovic
BACKGROUND: Pimavanserin is a selective 5-HT 2A receptor inverse agonist and antagonist approved in the USA for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. No safe or effective pharmacological treatment is approved for psychosis in patients with Alzheimer's disease. Therefore, we aimed to evaluate the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer's disease psychosis. METHODS: We did a phase 2, randomised, double-blind, placebo-controlled, single-centre (with multiple affiliated nursing home sites across the UK) study...
March 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29452193/antidepressant-activity-of-vorinostat-is-associated-with-amelioration-of-oxidative-stress-and-inflammation-in-a-corticosterone-induced-chronic-stress-model-in-mice
#13
Athira Kv, Rajaram Mohanrao Madhana, Indu Chandran Js, Mangala Lahkar, Swapnil Sinha, V G M Naidu
Major depressive disorder (MDD) is a multifactorial neuropsychiatric disorder. Chronic administration of corticosterone (CORT) to rodents is used to mimic the stress associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, a well-established feature found in depressive patients. Recently, preclinical studies have demonstrated the antidepressant potential of histone deacetylase (HDAC) inhibitors. So, we examined the antidepressant potential of vorinostat (VOR), a HDAC inhibitor against CORT injections in male mice...
February 13, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29451585/psychoactive-substance-abuse-and-dependence-and-its-association-with-anxiety-disorders-a-population-based-study-of-young-adults-in-brazil
#14
Mariana B de Matos, Christian L de Mola, Jéssica P Trettim, Karen Jansen, Ricardo A da Silva, Luciano D de Mattos Souza, Liliane da Costa Ores, Mariane L Molina, Fernanda T Coelho, Ricardo T Pinheiro, Luciana de A Quevedo
OBJECTIVE: To evaluate the association between abuse of and dependence on different psychoactive substances and the presence of anxiety disorders in a sample of young adults from a city in southern Brazil. METHODS: Between 2007 and 2009, we carried out a cross-sectional, population-based study of individuals aged 18-24 years who lived in Pelotas, a city in southern Brazil. We evaluated anxiety disorders using the Mini International Neuropsychiatric Interview 5.0 (MINI), and use of psychoactive substances with the Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST 2...
February 15, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29451519/-hepatitis-c-virus-infections-is-it-only-e-liver-disease
#15
Salvatore Petta
Hepatitis C virus (HCV) infection is widely diffused in general population, and the likelihood that an infected individual is affected by other disesases is high. A lot of epidemiological and explicative studies, even if with different levels of evidence, reported a potential effect of HCV infection -by direct and indirect mechanisms- on the pathogenesis of extrahepatic comorbidities related to dysregulation of the immune system, or cardiometabolic comorbidities like diabetes, neuropsychiatric disorders, chronic kidney disease, cardiovascular alterations, etc...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29449817/clinical-factors-associated-with-brain-volume-reduction-in-systemic-lupus-erythematosus-patients-without-major-neuropsychiatric-manifestations
#16
Shuang Liu, Yuqi Cheng, Yueyin Zhao, Hongjun Yu, Aiyun Lai, Zhaoping Lv, Xiufeng Xu, Chunrong Luo, Baoci Shan, Lin Xu, Jian Xu
The aim of the study was to find structural brain changes in systemic lupus erythematosus patients without major neuropsychiatric manifestations [non-neuropsychiatric systemic lupus erythematosus (non-NPSLE)] using quantitative magnetic resonance imaging (MRI) and possible associations with clinical characteristics. 89 non-NPSLE patients with normal conventional MRI and 84 healthy controls (HCs) were recruited. The whole brain gray matter volume (GMV) and white matter volume (WMV) were calculated for each individual...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29449810/recent-advances-in-cns-p2x7-physiology-and-pharmacology-focus-on-neuropsychiatric-disorders
#17
REVIEW
Anindya Bhattacharya
The ATP-gated P2X7 ion channel is an abundant microglial protein in the CNS that plays an important pathological role in executing ATP-driven danger signal transduction. Emerging data has generated scientific interest and excitement around targeting the P2X7 ion channel as a potential drug target for CNS disorders. Over the past years, a wealth of data has been published on CNS P2X7 biology, in particular the role of P2X7 in microglial cells, and in vivo effects of brain-penetrant P2X7 antagonists. Likewise, significant progress has been made around the medicinal chemistry of CNS P2X7 ligands, as antagonists for in vivo target validation in models of CNS diseases, to identification of two clinical compounds (JNJ-54175446 and JNJ-55308942) and finally, discovery of P2X7 PET ligands...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29449712/imaging-structural-and-functional-brain-development-in-early-childhood
#18
REVIEW
John H Gilmore, Rebecca C Knickmeyer, Wei Gao
In humans, the period from term birth to ∼2 years of age is characterized by rapid and dynamic brain development and plays an important role in cognitive development and risk of disorders such as autism and schizophrenia. Recent imaging studies have begun to delineate the growth trajectories of brain structure and function in the first years after birth and their relationship to cognition and risk of neuropsychiatric disorders. This Review discusses the development of grey and white matter and structural and functional networks, as well as genetic and environmental influences on early-childhood brain development...
February 16, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29449431/wilson-disease-more-than-meets-the-eye
#19
REVIEW
Claire Kelly, Marinos Pericleous
Wilson disease is a rare but important disorder of copper metabolism, with a failure to excrete copper appropriately into bile. It is a multisystem condition with presentations across all branches of medicine. Diagnosis can be difficult and requires a high index of suspicion. It should be considered in unexplained liver disease particularly where neuropsychiatric features are also present. Treatments are available for all stages of disease. A particularly important presentation not to overlook is acute liver failure which carries a high mortality risk and may require urgent liver transplantation...
February 15, 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29449373/tyrosine-hydroxylase-down-regulation-after-loss-of-abelson-helper-integration-site-1-ahi1-promotes-depression-via-the-circadian-clock-pathway-in-mice
#20
Dongkai Guo, Shun Zhang, Hongyang Sun, Xingyun Xu, Zongbing Hao, Chenchen Mu, Xingshun Xu, Guanghui Wang, Haigang Ren
Abelson helper integration site 1 (AHI1) is associated with several neuropsychiatric and brain developmental disorders such as schizophrenia, depression, autism, and Joubert syndrome. Ahi1 deficiency in mice leads to behaviors typical of depression. However, the mechanisms by which AHI1 regulates behavior remain to be elucidated. Here, we found that down-regulation of expression of the rate-limiting enzyme in dopamine biosynthesis, tyrosine hydroxylase (TH), in the midbrains of Ahi1 -knockout (KO) mice is responsible for Ahi1 -deficiency-mediated depressive symptoms...
February 15, 2018: Journal of Biological Chemistry
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