Kynon J M Benjamin, Ria Arora, Arthur S Feltrin, Geo Pertea, Hunter H Giles, Joshua M Stolz, Laura D'Ignazio, Leonardo Collado-Torres, Joo Heon Shin, William S Ulrich, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger, Apuã C M Paquola, Jennifer A Erwin
Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features, including differential symptomatology, drug responsiveness, and male incidence rate. Prior large-scale transcriptome analyses for sex differences in schizophrenia have focused on the prefrontal cortex. Analyzing BrainSeq Consortium data (caudate nucleus: n = 399, dorsolateral prefrontal cortex: n = 377, and hippocampus: n = 394), we identified 831 unique genes that exhibit sex differences across brain regions, enriched for immune-related pathways...
May 10, 2024: Nature Communications