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American trypanosomiasis

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https://www.readbyqxmd.com/read/29695139/comparative-analysis-of-repetitive-dna-between-the-main-vectors-of-chagas-disease-triatoma-infestans-and-rhodnius-prolixus
#1
Sebastián Pita, Pablo Mora, Jesús Vela, Teresa Palomeque, Antonio Sánchez, Francisco Panzera, Pedro Lorite
Chagas disease or American trypanosomiasis affects six to seven million people worldwide, mostly in Latin America. This disease is transmitted by hematophagous insects known as "kissing bugs" (Hemiptera, Triatominae), with Triatoma infestans and Rhodnius prolixus being the two most important vector species. Despite the fact that both species present the same diploid chromosome number (2 n = 22), they have remarkable differences in their total DNA content, chromosome structure and genome organization...
April 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29668134/-anti-trypanosoma-cruzi-antibodies-in-latin-american-migrants-in-transit-through-the-m%C3%A3-xico-usa-border
#2
Laura Mayela Montes-Rincón, Lucio Galaviz-Silva, Zinnia Judith Molina-Garza
INTRODUCTION: In recent years, American trypanosomiasis has become an emergent public health problem in countries receiving migrant populations such as México, USA, Canada or those in Europe. OBJECTIVE: To analyze the prevalence of anti-Trypanosoma cruzi antibodies in Latin American migrants on their way to USA and Canada by means of serological techniques. MATERIAL AND METHODS: ELISA and IHA were performed to detect anti-T. cruzi antibodies...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29608573/development-of-a-trypanosoma-cruzi-strain-typing-assay-using-ms2-peptide-spectral-libraries-tc-stams2
#3
Gilberto Santos de Oliveira, Rebeca Kawahara, Livia Rosa-Fernandes, Simon Ngao Mule, Carla Cristi Avila, Marta M G Teixeira, Martin R Larsen, Giuseppe Palmisano
BACKGROUND: Chagas disease also known as American trypanosomiasis is caused by the protozoan Trypanosoma cruzi. Over the last 30 years, Chagas disease has expanded from a neglected parasitic infection of the rural population to an urbanized chronic disease, becoming a potentially emergent global health problem. T. cruzi strains were assigned to seven genetic groups (TcI-TcVI and TcBat), named discrete typing units (DTUs), which represent a set of isolates that differ in virulence, pathogenicity and immunological features...
April 2, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29601585/trypanosoma-cruzi-80-kda-prolyl-oligopeptidase-tc80-as-a-novel-immunogen-for-chagas-disease-vaccine
#4
Augusto E Bivona, Andrés Sánchez Alberti, Marina N Matos, Natacha Cerny, Alejandro C Cardoso, Celina Morales, Germán González, Silvia I Cazorla, Emilio L Malchiodi
BACKGROUND: Chagas disease, also known as American Trypanosomiasis, is a chronic parasitic disease caused by the flagellated protozoan Trypanosoma cruzi that affects about 8 million people around the world where more than 25 million are at risk of contracting the infection. Despite of being endemic on 21 Latin-American countries, Chagas disease has become a global concern due to migratory movements. Unfortunately, available drugs for the treatment have several limitations and they are generally administered during the chronic phase of the infection, when its efficacy is considered controversial...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29569002/mast-cells-and-serotonin-synthesis-modulate-chagas-disease-in-the-colon-clinical-and-experimental-evidence
#5
Vinicius Kannen, Juliana Y Sakita, Zumira A Carneiro, Michael Bader, Natalia Alenina, Regina R Teixeira, Enio C de Oliveira, Mariângela O Brunaldi, Bianca Gasparotto, Daniela C Sartori, Cleverson R Fernandes, João S Silva, Marcus V Andrade, Wilson A Silva, Sergio A Uyemura, Sérgio B Garcia
BACKGROUND: Trypanosoma cruzi (T. cruzi) infects millions of Latin Americans each year and can induce chagasic megacolon. Little is known about how serotonin (5-HT) modulates this condition. Aim We investigated whether 5-HT synthesis alters T. cruzi infection in the colon. MATERIALS AND METHODS: Forty-eight paraffin-embedded samples from normal colon and chagasic megacolon were histopathologically analyzed (173/2009). Tryptophan hydroxylase 1 (Tph1) knockout (KO) mice and c-KitW-sh mice underwent T...
March 22, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29538505/vimentin-and-anti-vimentin-antibodies-in-chagas-disease
#6
Marilda Savoia Nascimento, Anna Maria Simonsen Stolf, Heitor Franco de Andrade Junior, Ramendra Pati Pandey, Eufrosina Setsu Umezawa
BACKGROUND: Vimentin is a main structural protein of the cell, a component of intermediate cell filaments and immersed in cytoplasm. Vimentin is mimicked by some bacterial proteins and anti-vimentin antibodies occur in autoimmune cardiac disease, as rheumatic fever. In this work we studied vimentin distribution on LLC-MK2 cells infected with T. cruzi and anti-vimentin antibodies in sera from several clinical pictures of Chagas' disease or American Trypanosomiasis, in order to elucidate any vimentin involvement in the humoral response of this pathology...
March 12, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29501946/identification-of-pyrazolo-3-4-e-1-4-thiazepin-based-cyp51-inhibitors-as-potential-chagas-disease-therapeutic-alternative-in-vitro-and-in-vivo-evaluation-binding-mode-prediction-and-sar-exploration
#7
Ludmila Ferreira de Almeida Fiuza, Raiza Brandão Peres, Marianne Rocha Simões-Silva, Patricia Bernardino da Silva, Denise da Gama Jaen Batista, Cristiane França da Silva, Aline Nefertiti Silva da Gama, Tummala Rama Krishna Reddy, Maria de Nazaré Correia Soeiro
American trypanosomiasis or Chagas disease (CD) is a vector borne pathology caused by the parasite Trypanosoma cruzi (T. cruzi), which remains a serious global health problem. The current available treatment for CD is limited to two nitroderivatives with limited efficacy and several side effects. The rational design of ergosterol synthetic route inhibitors (e.g. CYP51 inhibitors) represents a promising strategy for fungi and trypanosomatids, exhibiting excellent anti-T.cruzi activity in pre-clinical assays...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29368453/the-role-of-hla-g-in-parasitic-diseases
#8
REVIEW
A Sabbagh, P Sonon, I Sadissou, C T Mendes-Junior, A Garcia, E A Donadi, D Courtin
Little attention has been devoted to the role of HLA-G gene and molecule on parasitic disorders, and the available studies have focused on malaria, African and American trypanosomiasis, leishmaniosis, toxoplasmosis and echinococcosis. After reporting a brief description regarding the role of the cells of innate and adaptive immune system against parasites, we reviewed the major features of the HLA-G gene and molecule and the role of HLA-G on the major cells of immune system. Increased levels of soluble HLA-G (sHLA-G) have been observed in patients presenting toxoplasmosis and in the active phase of echinococcosis...
January 25, 2018: HLA
https://www.readbyqxmd.com/read/29304849/should-i-stay-or-should-i-go-movement-of-adult-triatoma-sordida-within-the-peridomestic-area-of-a-typical-brazilian-cerrado-rural-household
#9
Edson Santos Dantas, Rodrigo Gurgel-Gonçalves, Daniel Antunes Maciel Villela, Fernando Araújo Monteiro, Rafael Maciel-de-Freitas
BACKGROUND: Chagas disease, or American trypanosomiasis, is an important neglected tropical illness caused by the flagellate protozoan Trypanosoma cruzi, which is primarily transmitted to humans by hematophagous insects of the subfamily Triatominae. Although knowledge on triatomine movement capabilities at the micro-geographical scale is of fundamental importance concerning the development of effective vector control strategies, it remains a poorly understood subject. Furthermore, survival rates and size estimates of natural populations are important topics to consider when evaluating transmission intensity...
January 5, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29286188/the-mitochondrial-calcium-uniporter-complex-in-trypanosomes
#10
REVIEW
Noelia Lander, Miguel A Chiurillo, Mayara S Bertolini, Roberto Docampo, Aníbal E Vercesi
The presence of a conserved mechanism for mitochondrial calcium uptake in trypanosomatids was crucial for the molecular identification of the mitochondrial calcium uniporter (MCU), a long-sought channel present in most eukaryotic organisms. Since then, research efforts to elucidate the role of MCU and its regulatory elements in different biological models have multiplied. MCU is the pore-forming subunit of a multimeric complex (the MCU complex or MCUC) and its predicted structure in trypanosomes is simpler than in mammalian cells, lacking two of its subunits and probably possessing other unidentified components...
December 29, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29279084/spatial-temporal-and-phylogeographic-characterization-of-trypanosoma-spp-in-cattle-bos-taurus-and-buffaloes-bubalus-bubalis-reveals-transmission-dynamics-of-these-parasites-in-colombia
#11
Jeiczon Jaimes-Dueñez, Omar Triana-Chávez, Ana M Mejía-Jaramillo
Animal Trypanosomiasis (AT) is one of the most important problems in the Colombian livestock industry reducing its production around 30%. Caribbean and Orinoquia regions play a significant role in the development of this industry, having about 6.9 million cattle and 113,000 buffaloes. Considering the paucity in studies to understand the epidemiological features and control of AT in Colombia, the present study reports the seasonal transmission patterns and phylogeographic traits of the causal agents of AT in cattle and buffaloes from these regions...
January 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29182646/transcriptome-wide-analysis-of-the-trypanosoma-cruzi-proliferative-cycle-identifies-the-periodically-expressed-mrnas-and-their-multiple-levels-of-control
#12
Santiago Chávez, Guillermo Eastman, Pablo Smircich, Lorena Lourdes Becco, Carolina Oliveira-Rizzo, Rafael Fort, Mariana Potenza, Beatriz Garat, José Roberto Sotelo-Silveira, María Ana Duhagon
Trypanosoma cruzi is the protozoan parasite causing American trypanosomiasis or Chagas disease, a neglected parasitosis with important human health impact in Latin America. The efficacy of current therapy is limited, and its toxicity is high. Since parasite proliferation is a fundamental target for rational drug design, we sought to progress into its understanding by applying a genome-wide approach. Treating a TcI linage strain with hydroxyurea, we isolated epimastigotes in late G1, S and G2/M cell cycle stages at 70% purity...
2017: PloS One
https://www.readbyqxmd.com/read/29118740/response-to-trypanosoma-cruzi-by-human-blood-cells-enriched-with-dentritic-cells-is-controlled-by-cyclooxygenase-2-pathway
#13
Sandra C H Lonien, Aparecida D Malvezi, Helena T Suzukawa, Lucy M Yamauchi, Sueli F Yamada-Ogatta, Luiz V Rizzo, Juliano Bordignon, Phileno Pinge-Filho
Chagas disease (Cd) or American human trypanosomiasis is caused by Trypanosoma cruzi and affects ~7 million people, mostly in Latin America. The infective trypomastigote forms of the parasite can invade several human blood cell populations, including monocytes and dendritic cells (DC). Although these cells display a wide functional diversity, their interactions with T. cruzi via cyclooxygenase (COX) and cyclic adenosine monophosphate (cAMP) dependent pathways have not been analyzed. To exploiting this mechanism, DC-enriched peripheral human blood mononuclear cell populations (DC-PBMC) were used as our model...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29107437/selenium-containing-analogues-of-wc-9-are-extremely-potent-inhibitors-of-trypanosoma-cruzi-proliferation
#14
María N Chao, Melissa Storey, Catherine Li, Maricel G Rodríguez, Florencia Di Salvo, Sergio H Szajnman, Silvia N J Moreno, Roberto Docampo, Juan B Rodriguez
The obligate intracellular parasite, Trypanosoma cruzi is the etiologic agent of Chagas disease or American trypanosomiasis, which is the most prevalent parasitic disease in the Americas. The present chemotherapy to control this illness is still deficient particularly in the chronic stage of the disease. The ergosterol biosynthesis pathway has received much attention as a molecular target for the development of new drugs for Chagas disease. Especially, inhibitors of the enzymatic activity of squalene synthase were shown to be effective compounds on T...
December 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29084172/benzoic-acid-derivatives-with-trypanocidal-activity-enzymatic-analysis-and-molecular-docking-studies-toward-trans-sialidase
#15
Muhammad Kashif, Antonio Moreno-Herrera, Juan Carlos Villalobos-Rocha, Benjamín Nogueda-Torres, Jaime Pérez-Villanueva, Karen Rodríguez-Villar, José Lius Medina-Franco, Peterson de Andrade, Ivone Carvalho, Gildardo Rivera
Chagas, or American trypanosomiasis, remains an important public health problem in developing countries. In the last decade, trans-sialidase has become a pharmacological target for new anti-Chagas drugs. In this work, the aims were to design and find a new series of benzoic acid derivatives as trans-sialidase (TS) inhibitors and anti-trypanosomal agents. Three compounds (14, 18, and 19) sharing a para-aminobenzoic acid moiety showed more potent trypanocidal activity than the commercially available drugs nifurtimox and benznidazole in both strains: the lysis concentration of 50% of the population (LC50) was <0...
October 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29017584/american-trypanosomiasis-or-chagas-disease-in-panama-a-chronological-synopsis-of-ecological-and-epidemiological-research
#16
REVIEW
Indra G Rodriguez, Jose R Loaiza
American trypanosomiasis, or Chagas disease, is a growing public health problem in Panama, and further forest degradation due to human population growth is expected to worsen the situation. Most people infected with the parasite Trypanosoma cruzi are silently ill, and their life expectancy is severely compromised, which contributes to further deterioration of living conditions in endemic regions. Here, we review the outcomes of nearly 100 years of ecological and epidemiological investigation about Chagas disease in Panama, in an attempt to highlight progress, identify needs, and re-orient future efforts...
October 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28935948/novel-scaffolds-for-inhibition-of-cruzipain-identified-from-high-throughput-screening-of-anti-kinetoplastid-chemical-boxes
#17
Emir Salas-Sarduy, Lionel Urán Landaburu, Joel X Karpiak, Kevin P Madauss, Juan José Cazzulo, Fernán Agüero, Vanina Eder Alvarez
American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only to nifurtimox and benznidazole, two drugs that have poor efficacy in the chronic phase and are rather toxic. In this scenario, more efficacious and safer drugs, preferentially acting through a different mechanism of action and directed against novel targets, are particularly welcome. Cruzipain, the main papain-like cysteine peptidase of T...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28919885/trypanosoma-cruzi-evades-the-complement-system-as-an-efficient-strategy-to-survive-in-the-mammalian-host-the-specific-roles-of-host-parasite-molecules-and-trypanosoma-cruzi-calreticulin
#18
REVIEW
Galia Ramírez-Toloza, Arturo Ferreira
American Trypanosomiasis is an important neglected reemerging tropical parasitism, infecting about 8 million people worldwide. Its agent, Trypanosoma cruzi, exhibits multiple mechanisms to evade the host immune response and infect host cells. An important immune evasion strategy of T. cruzi infective stages is its capacity to inhibit the complement system activation on the parasite surface, avoiding opsonizing, immune stimulating and lytic effects. Epimastigotes, the non-infective form of the parasite, present in triatomine arthropod vectors, are highly susceptible to complement-mediated lysis while trypomastigotes, the infective form, present in host bloodstream, are resistant...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28807005/first-records-of-triatoma-rubrofasciata-de-geer-1773-hemiptera-reduviidae-in-foshan-guangdong-province-southern-china
#19
Qin Liu, Yun-Hai Guo, Yi Zhang, Zheng-Bin Zhou, Liang-Liang Zhang, Dan Zhu, Xiao-Nong Zhou
BACKGROUND: Triatomines, also known as kissing bugs, which are found throughout the world and especially in Latin America, are well known natural vectors that transmit American trypanosomiasis, also called Chagas disease. In China, the presence of two species of Triatoma (Triatoma rubrofasciata and T. sinica) was recorded in the past. Due to the growing population and the increasing risk of the global spread of Chagas disease, triatomines became a potential public health nuisance, and in 2016, we started monitoring triatomine activities in southern China...
August 15, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28723901/2b-rad-genotyping-for-population-genomic-studies-of-chagas-disease-vectors-rhodnius-ecuadoriensis-in-ecuador
#20
Luis E Hernandez-Castro, Marta Paterno, Anita G Villacís, Björn Andersson, Jaime A Costales, Michele De Noia, Sofía Ocaña-Mayorga, Cesar A Yumiseva, Mario J Grijalva, Martin S Llewellyn
BACKGROUND: Rhodnius ecuadoriensis is the main triatomine vector of Chagas disease, American trypanosomiasis, in Southern Ecuador and Northern Peru. Genomic approaches and next generation sequencing technologies have become powerful tools for investigating population diversity and structure which is a key consideration for vector control. Here we assess the effectiveness of three different 2b restriction site-associated DNA (2b-RAD) genotyping strategies in R. ecuadoriensis to provide sufficient genomic resolution to tease apart microevolutionary processes and undertake some pilot population genomic analyses...
July 2017: PLoS Neglected Tropical Diseases
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