Gador Bogas, Cristobalina Mayorga, Ángela Martín-Serrano, Rubén Fernández-Santamaría, Isabel M Jiménez-Sánchez, Adriana Ariza, Esther Barrionuevo, Teresa Posadas, María Salas, Tahía Diana Fernández, María José Torres, María Isabel Montañez
BACKGROUND: Analysis of cross-reactivity is necessary for prescribing safe cephalosporins for penicillin allergic patients. Amoxicillin (AX) is the betalactam most often involved in immediate hypersensitivity reactions (IHRs), and cefadroxil (CX) the most likely cephalosporin to cross-react with AX, since they share the same R1 side chain, unlike cefuroxime (CO), with a structurally different R1. We aimed to analyse cross-reactivity with CX and CO in patients with confirmed IHRs to AX, including sIgE recognition to AX, CX, CO, and novel synthetic determinants of CX...
December 4, 2020: Clinical and Translational Allergy