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Cephalosporin cross reactivity

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https://www.readbyqxmd.com/read/28814358/frequency-of-selective-immediate-responders-to-aminopenicillins-and-cephalosporins-in-turkish-children
#1
Emine Dibek Misirlioglu, Hakan Guvenir, Muge Toyran, Emine Vezir, Murat Capanoglu, Ersoy Civelek, Betul Buyuktiryaki, Tayfur Ginis, Can Naci Kocabas
BACKGROUND: Beta-lactam antibiotics (BLA) are the most commonly prescribed antibiotics and are responsible for the majority of immediate hypersensitivity reactions to drugs in children. Cross-reactivity is important in hypersensitivity to BLAs because these drugs all share a common beta-lactam structure and some share similar side chains. OBJECTIVE: The aim of this study was to evaluate the clinical characteristics of patients who are diagnosed with immediate-type BLA hypersensitivity and frequency of patients with side chain hypersensitivity, "selective responders...
September 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28577519/drug-allergy-evaluation-for-betalactam-hypersensitivity-cross-reactivity-with-cephalosporines-carbapenems-and-negative-predictive-value
#2
Mona Al-Ahmad, Tito Rodriguez-Bouza
BACKGROUND: There are no studies on cross-reactivity of betalactams among patients allergic to penicillin, or on the negative predictive value (NPV) of penicillin allergy evaluation from Arabian Gulf countries OBJECTIVE: We aimed to assess the role and NPV of drug provocation test (DPT) for betalactam hypersensitivity reactions in patients referred for allergy evaluation in Kuwait METHODS: Skin test (ST) was performed for all patients with a history of betalactam hypersensitivity, other than anaphylaxis...
June 1, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28539186/a-survey-of-inpatient-practitioner-knowledge-of-penicillin-allergy-at-2-community-teaching-hospitals
#3
Mary L Staicu, Dipekka Soni, Kelly M Conn, Allison Ramsey
BACKGROUND: The negative effect of the penicillin allergy label on antibiotic use and patient outcomes has brought to light the need for thorough penicillin allergy assessments and heightened practitioner education. OBJECTIVE: To evaluate practitioner knowledge of penicillin allergy and the clinical approach to the patients with penicillin allergy. METHODS: An electronic survey was distributed to attending physicians, residents, pharmacists, nurse practitioners, and physician assistants practicing adult inpatient medicine at 2 community-based teaching hospitals from February to April 2016...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28438590/antibiotic-prophylaxis-in-cataract-surgery-in-the-setting-of-penicillin-allergy-a-decision-making-algorithm
#4
REVIEW
Benjamin R LaHood, Nicholas H Andrew, Michael Goggin
Cataract surgery is the most commonly performed surgical procedure in many developed countries. Postoperative endophthalmitis is a rare complication with potentially devastating visual outcomes. Currently, there is no global consensus regarding antibiotic prophylaxis in cataract surgery despite growing evidence of the benefits of prophylactic intracameral cefuroxime at the conclusion of surgery. The decision about which antibiotic regimen to use is further complicated in patients reporting penicillin allergy...
April 22, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27934618/cross-reactivity-of-cephalosporins-allergic-immediate-hypersensitivity-to-ceftriaxone-in-a-cefcapene-pivoxil-sensitized-patient
#5
Tokiko Deguchi, Yutaka Shimomura, Ryota Hayashi, Mari Orime, Katsuhiro Tomiyama, Riichiro Abe
No abstract text is available yet for this article.
December 8, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27527526/return-to-sender-the-need-to-re-address-patient-antibiotic-allergy-labels-in-australia-and-new-zealand
#6
J A Trubiano, L J Worth, K Urbancic, T M Brown, D L Paterson, M Lucas, E Phillips
BACKGROUND/AIM: Antibiotic allergies are frequently reported and have significant impacts upon appropriate prescribing and clinical outcomes. We surveyed infectious diseases physicians, allergists, clinical immunologists and hospital pharmacists to evaluate antibiotic allergy knowledge and service delivery in Australia and New Zealand. METHODS: An online multi-choice questionnaire was developed and endorsed by representatives of the Australasian Society of Clinical Immunology and Allergy (ASCIA) and the Australasian Society of Infectious Diseases (ASID)...
November 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27477905/patch-testing-a-valuable-tool-for-investigating-non-immediate-cutaneous-adverse-drug-reactions-to-antibiotics
#7
A Pinho, I Coutinho, A Gameiro, M Gouveia, M Gonçalo
BACKGROUND: Antibiotics are among the most frequent causes of cutaneous adverse drug reactions (CADR); patch testing may be an important tool in their evaluation and management. We assessed the role of patch testing as a diagnostic tool in non-immediate CADR to antibiotics, and evaluated cross-reactivity among them. METHODS: We reviewed data from all patients with non-immediate CADR attributed to antibiotics, which were patch tested between 2000 and 2014 at our dermatology department...
February 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27317018/cefazolin-hypersensitivity-toward-optimized-diagnosis
#8
Astrid P Uyttebroek, Ine I Decuyper, Chris H Bridts, Antonino Romano, Margo M Hagendorens, Didier G Ebo, Vito Sabato
BACKGROUND: Correct diagnosis of cefazolin hypersensitivity is not straightforward, mainly because of the absence of in vitro tests and uncertainties concerning the optimal cefazolin concentration for skin testing. Cross-reactivity studies suggest cefazolin hypersensitivity to be a selective hypersensitivity. OBJECTIVE: The first objective was to confirm that the application of a higher than 2 mg/mL test concentration could increase skin test sensitivity. A second part aimed at investigating the cross-reactivity between cefazolin and other β-lactam antibiotics...
November 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27225407/multiplex-real-time-pcr-assay-with-high-resolution-melting-analysis-for-characterization-of-antimicrobial-resistance-in-neisseria-gonorrhoeae
#9
Valentina Donà, Sara Kasraian, Agnese Lupo, Yuvia N Guilarte, Christoph Hauser, Hansjakob Furrer, Magnus Unemo, Nicola Low, Andrea Endimiani
Resistance to antibiotics used against Neisseria gonorrhoeae infections is a major public health concern. Antimicrobial resistance (AMR) testing relies on time-consuming culture-based methods. Development of rapid molecular tests for detection of AMR determinants could provide valuable tools for surveillance and epidemiological studies and for informing individual case management. We developed a fast (<1.5-h) SYBR green-based real-time PCR method with high-resolution melting (HRM) analysis. One triplex and three duplex reactions included two sequences for N...
August 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27025522/evaluation-of-a-computerized-decision-support-intervention-to-decrease-use-of-anti-pseudomonal-carbapenems-in-penicillin-allergic-patients
#10
Christina Caplinger, Garret Smith, Richard Remington, Karl Madaras-Kelly
Allergies to β-lactam antibiotics are commonly documented in hospitalized patients; however, true allergy is uncommon. Cross-reactivity rates for advanced generation cephalosporins and carbapenems are low; particularly for patients without a history of symptoms consistent with type 1 hypersensitivity. We observed that providers preferentially prescribed antipseudomonal carbapenems (APC) over advanced generation cephalosporins for patients with β-lactam allergy history, including those with low risk for antimicrobial-resistant infections...
2016: Antibiotics
https://www.readbyqxmd.com/read/27016799/cross-reactivity-and-tolerability-of-aztreonam-and-cephalosporins-in-subjects-with-a-t%C3%A2-cell-mediated-hypersensitivity-to-penicillins
#11
Antonino Romano, Francesco Gaeta, Rocco Luigi Valluzzi, Michela Maggioletti, Cristiano Caruso, Donato Quaratino
BACKGROUND: The few studies performed in adults with T cell-mediated hypersensitivity to penicillins have found a rate of cross-reactivity with cephalosporins ranging from 2.8% to 31.2% and an absence of cross-reactivity with aztreonam. OBJECTIVE: We sought to evaluate the possibility of using cephalosporins and aztreonam in subjects with documented delayed hypersensitivity to penicillins who especially require them. METHODS: We conducted a prospective study of 214 consecutive subjects who had 307 nonimmediate reactions to penicillins (almost exclusively aminopenicillins) and had positive patch test and/or delayed-reading skin test responses to at least 1 penicillin reagent...
July 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26898316/cross-reactivity-among-beta-lactams
#12
REVIEW
Antonino Romano, Francesco Gaeta, Maria Francisca Arribas Poves, Rocco Luigi Valluzzi
Penicillins and cephalosporins are the major classes of beta-lactam (BL) antibiotics in use today and one of the most frequent causes of hypersensitivity reactions to drugs. Monobactams, carbapenems, oxacephems, and beta-lactamase inhibitors constitute the four minor classes of BLs. This review takes into account mainly the prospective studies which evaluated cross-reactivity among BLs in subjects with a well-demonstrated hypersensitivity to a certain class of BLs by performing allergy tests with alternative BLs and, in case of negative results, administering them...
March 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/26556109/prophylactic-antibiotic-management-of-surgical-patients-noted-as-allergic-to-penicillin-at-two-academic-hospitals
#13
MULTICENTER STUDY
Richard H Epstein, Paul St Jacques, Jonathan P Wanderer, Mark R Bombulie, Niraj Agarwalla
We studied prophylactic antibiotics administered at 2 academic medical centers during a 6-year period where a cephalosporin was indicated but an "allergy" to penicillin was noted. Another drug (typically vancomycin or clindamycin) was substituted approximately 80% of the time; this occurred frequently even when symptoms unrelated to acute hypersensitivity were listed. In >50% of cases, the reaction was either omitted or vague (e.g., simply "rash"). Given the estimated 1% cross-reactivity between penicillins and cephalosporins with similar R1 side chains, many of these patients could have received either the prescribed cephalosporin or another cephalosporin with a different R1 side chain...
May 1, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/26553624/cephalosporin-side-chain-cross-reactivity
#14
Dennis K Ledford
No abstract text is available yet for this article.
November 2015: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/26549341/an-unusual-case-of-delayed-type-hypersensitivity-to-ceftriaxone-and-meropenem
#15
E Dias de Castro, A Leblanc, A Sarmento, J R Cernadas
Recent studies have demonstrated a low cross-reactivity between β-lactam antibiotics and carbapenems in IgE-mediated reactions. There are no studies on cross-reactivity of meropenem in patients with non-immediate hypersensitivity to cephalosporins. We describe a case of a 13-year-old male, admitted in Neurosurgery with a severe extradural empyema complicating frontal sinusitis, submitted to an emergent bifrontal craniotomy. A generalized maculopapular exanthema, fever and malaise, appeared by the 7th day of meningeal doses of ceftriaxone, clindamycin and vancomycin...
November 2015: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26416019/design-of-a-sensitive-fluorescent-polarization-immunoassay-for-rapid-screening-of-milk-for-cephalexin
#16
Natalia V Beloglazova, Sergei A Eremin
In this paper we describe the development of a sensitive, fast, and easily performed fluorescence polarization immunoassay for determination of cephalexin in milk. The experimental work was performed to increase sensitivity and specificity. Therefore, the structures of the tracers were varied by synthesis of both cephalexin (CEX) and cephalotin (CET) conjugates with a variety of fluorescent labels. Two rabbit antisera containing antibodies against cephalexin and cephalotin were tested in homologous and heterologous combinations with the tracers...
November 2015: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/26182689/no-cross-reactivity-with-cephalosporins-in-patients-with-penicillin-allergy
#17
J A Martinez Tadeo, E Perez Rodriguez, Z Almeida Sanchez, A Callero Viera, J C Garcia Robaina
No abstract text is available yet for this article.
2015: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/25930196/ige-mediated-hypersensitivity-to-cephalosporins-cross-reactivity-and-tolerability-of-alternative-cephalosporins
#18
Antonino Romano, Francesco Gaeta, Rocco Luigi Valluzzi, Michela Maggioletti, Alessandra Zaffiro, Cristiano Caruso, Donato Quaratino
BACKGROUND: Studies regarding the cross-reactivity and tolerability of alternative cephalosporins in large samples of subjects with an IgE-mediated hypersensitivity to cephalosporins are lacking. OBJECTIVE: We sought to evaluate the possibility of using alternative cephalosporins in subjects with cephalosporin allergy who especially require them. METHODS: One hundred two subjects with immediate reactions to cephalosporins and positive skin test results to the responsible drugs underwent serum specific IgE assays with cefaclor and skin tests with different cephalosporins...
September 2015: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/25783308/penicillin-allergy-and-surgical-prophylaxis-cephalosporin-cross-reactivity-risk-in-a-pediatric-tertiary-care-center
#19
Ralph J Beltran, Hiromi Kako, Thomas Chovanec, Archana Ramesh, Bruno Bissonnette, Joseph D Tobias
BACKGROUND: First generation cephalosporins are commonly used as antibiotic prophylaxis prior to surgery. Patients labeled as penicillin-allergic are often precluded from receiving cephalosporins because of an allergic cross-reactivity. The aims of this study were to evaluate the clinical practice for surgical prophylaxis at Nationwide Children's Hospital and to determine the incidence of adverse effects and allergic reactions when using cephalosporins in patients labeled as penicillin-allergic...
May 2015: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/25752938/cephalosporin-use-in-penicillin-allergic-patients-a-survey-of-otolaryngologists-and-literature-review
#20
REVIEW
Michael J Persky, Scott A Roof, Yixin Fang, Daniel Jethanamest, Max M April
OBJECTIVES/HYPOTHESIS: This study investigated the differences between the standard guidelines and the practice patterns of otolaryngologists in managing "penicillin-allergic" patients. A major goal was to identify factors influencing an otolaryngologist's choice of antibiotic. STUDY DESIGN: Cross-sectional survey. METHODS: Four hundred seventy members of the American Society of Pediatric Otolaryngologists (ASPO) and 150 general otolaryngologists from the Florida Society of Otolaryngology (FSO) were surveyed...
August 2015: Laryngoscope
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