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Trabecular meshwork

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https://www.readbyqxmd.com/read/29141392/-the-progress-of-studies-on-aqueous-humor-dynamics-abnormality-induced-by-trabecular-meshwork-and-schlemm-canal-endothelial-cell-senescence-and-its-relation-with-glaucoma
#1
M M Song, Y Lei, J H Wu, X H Sun
Glaucoma is the second leading cause of blindness in the world next to cataract. Aging is a strong risk factor leading to elevated intraocular pressure (IOP). IOP is associated with aqueous humor circulation. Trabecular meshwork cells and Schlemm canal endothelial cells, which form the conventional outflow pathway, play an important role in maintaining the IOP. Cell senescence induces abnormalities of the aqueous humor dynamics, leading to elevated IOP. Trabecular meshwork cells cause increased intrinsic stiffness, autophagy dysfunction, abnormal expression of microRNA and mitochondrial dysfunction with senescence...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133761/reduction-on-off-responses-of-electroretinogram-in-monkeys-with-long-term-high-intraocular-pressure
#2
Ke-Gao Liu, Xiao-Yan Peng, Zheng Zhang, Hua Sun, Di-Ya Yang, Ning-Li Wang
BACKGROUND: There are ON- and OFF-pathways in the normal vertebrate retina. Short- and long-flash electroretinogram (ERG) are suitable methods to observe the function of ON- and OFF-pathways in vivo, respectively. It is clear that high intraocular pressure (IOP) might cause dysfunction of cone-dominated photopic negative response (PhNR) in monkeys with high IOP in ON-pathway. However, whether cone-dominated OFF-responses are also affected is less known. The aim of this study was to observe photopic OFF-responses of ERG in monkeys with high IOP...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29115373/yap-and-taz-mediate-steroid-induced-alterations-in-the-trabecular-meshwork-cytoskeleton-in-human-trabecular-meshwork-cells
#3
Jie Peng, Hailian Wang, Xin Wang, Minghan Sun, Shaoping Deng, Yi Wang
Primary open angle glaucoma is an important type of glaucoma as it is one of the most common causes of blindness. Previous studies have demonstrated that in glaucomatous patients, the human trabecular meshwork (HTM) is markedly stiffened. The purpose of the present study was to determine the regulatory role of Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in HTM cells. Primary HTM cells were cultured with different concentrations of dexamethasone (DEX), and the expression levels of YAP and TAZ were evaluated using reverse transcription-quantitative polymerase chain reaction and western blotting...
October 23, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29114841/effect-of-cromakalim-prodrug-1-cklp1-on-aqueous-humor-dynamics-and-feasibility-of-combination-therapy-with-existing-ocular-hypotensive-agents
#4
Uttio Roy Chowdhury, Tommy A Rinkoski, Cindy K Bahler, J Cameron Millar, Jacques A Bertrand, Bradley H Holman, Joseph M Sherwood, Darryl R Overby, Kristen L Stoltz, Peter I Dosa, Michael P Fautsch
Purpose: Cromakalim prodrug 1 (CKLP1) is a water-soluble ATP-sensitive potassium channel opener that has shown ocular hypotensive properties in ex vivo and in vivo experimental models. To determine its mechanism of action, we assessed the effect of CKLP1 on aqueous humor dynamics and in combination therapy with existing ocular hypotensive agents. Methods: Outflow facility was assessed in C57BL/6 mice by ex vivo eye perfusions and by in vivo constant flow infusion following CKLP1 treatment...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29106382/angiopoietin-1-is-required-for-schlemm-s-canal-development-in-mice-and-humans
#5
Benjamin R Thomson, Tomokazu Souma, Stuart W Tompson, Tuncer Onay, Krishnakumar Kizhatil, Owen M Siggs, Liang Feng, Kristina N Whisenhunt, Tammy L Yanovitch, Luba Kalaydjieva, Dimitar N Azmanov, Simone Finzi, Christine E Tanna, Alex W Hewitt, David A Mackey, Yasmin S Bradfield, Emmanuelle Souzeau, Shari Javadiyan, Janey L Wiggs, Francesca Pasutto, Xiaorong Liu, Simon Wm John, Jamie E Craig, Jing Jin, Terri L Young, Susan E Quaggin
Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. Here, we describe roles for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure...
November 6, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29097767/increased-synthesis-and-deposition-of-extracellular-matrix-proteins-leads-to-endoplasmic-reticulum-stress-in-the-trabecular-meshwork
#6
Ramesh B Kasetti, Prabhavathi Maddineni, J Cameron Millar, Abbot F Clark, Gulab S Zode
Increased synthesis and deposition of extracellular matrix (ECM) proteins in the trabecular meshwork (TM) is associated with TM dysfunction and intraocular pressure (IOP) elevation in glaucoma. However, it is not understood how ECM accumulation leads to TM dysfunction and IOP elevation. Using a mouse model of glucocorticoid (GC)-induced glaucoma, primary human TM cells and human post-mortem TM tissues, we show that increased ECM accumulation leads to endoplasmic reticulum (ER) stress in the TM. The potent GC, dexamethasone (Dex) increased the secretory protein load of ECM proteins in the ER of TM cells, inducing ER stress...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29090051/fmnl2-with-functions-related-to-the-cytoskeleton-is-partially-regulated-by-pax6
#7
Elham Ghorbanpour, Parvin Pasalar, Shahin Yazdani, Hamidreza Moazzeni, Elahe Elahi
PURPOSE: We aimed to assess whether the transcription factor PAX6 affects transcription of FMNL2. PAX6 is a transcription factor with significant roles in development of the eye and eye-related functions. FMNL2 encodes a member of the formin family of proteins and has roles in polymerization of actin and features of the cytoskeleton. The state of the cytoskeleton affects the flow of aqueous humor, disruption of which is a cornerstone of glaucoma pathology. METHODS: Initially, bioinformatics were used extensively to identify FMNL2 as an appropriate candidate gene for possible targeting by PAX6...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29080912/baicalin-alleviates-oxidative-stress-damage-in-trabecular-meshwork-cells-in-vitro
#8
Lei Gong, Jianfeng Zhu
Oxidative stress and inflammation play a key role in pathophysiology of glaucoma. Baicalin is known as an anti-oxidative and anti-inflammatory substance, possessing the potential to treat glaucoma. This study was designed to assess the anti-oxidative and anti-inflammatory potentials in culture human trabecular meshwork (hTM) cells. Using hTM cells as the in vitro model, we investigated the effects of baicalin on oxidative stress-induced markers for hTM impairments. We pre-incubated hTM cells with baicalin before hydrogen peroxide stressing or pre- plus co-incubated with baicalin before and during stressing and monitored the cell death, production of intracellular reactive oxygen species (iROS) and inflammatory cytokines, accumulation of carbonylated proteins, and activity of senescence marker...
October 28, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29079753/norrin-protects-optic-nerve-axons-from-degeneration-in-a-mouse-model-of-glaucoma
#9
Stephanie A Leopold, Ludwig F Zeilbeck, Gregor Weber, Roswitha Seitz, Michael R Bösl, Herbert Jägle, Rudolf Fuchshofer, Ernst R Tamm, Andreas Ohlmann
Norrin is a secreted signaling molecule activating the Wnt/β-catenin pathway. Since Norrin protects retinal neurons from experimental acute injury, we were interested to learn if Norrin attenuates chronic damage of retinal ganglion cells (RGC) and their axons in a mouse model of glaucoma. Transgenic mice overexpressing Norrin in the retina (Pax6-Norrin) were generated and crossed with DBA/2J mice with hereditary glaucoma and optic nerve axonal degeneration. One-year old DBA/2J/Pax6-Norrin animals had significantly more surviving optic nerve axons than their DBA/2J littermates...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29077522/a-novel-uveolymphatic-drainage-pathway-possible-new-target-for-glaucoma-treatment
#10
Martyna Tomczyk-Socha, Anna Turno-Kręcicka
Glaucoma is a heterogeneous group of ophthalmic diseases leading to irreversible damage to the optic nerve. While the overall mechanism responsible for glaucoma remains obscure, the most important risk factor is elevated intraocular pressure. The current therapies, whether pharmacological or surgical, are primarily symptomatic with the aim to lower the intraocular pressure (IOP). Poorer response to treatment is associated, for example, with pseudoexfoliation glaucoma, which is determined by blocking the trabecular meshwork (TM) both by pigment grains and the pseudoexfoliation material...
October 27, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29076672/determination-of-association-of-pigmentary-glaucoma-with-pigment-dispersion-syndrome
#11
Imtiaz Ali Shah, Shujaat Ali Shah, Partab Rai Nagdev, Safdar Ali Abbasi, Naeem Ali Abbasi, Safdar Akhtar Katpar
BACKGROUND: Pigment Dispersion Syndrome (PDS) is an autosomal dominant disorder of white males between 20 to 40 years of age characterized by deposition of pigment on the lens, zonules of lens, trabecular meshwork and corneal endothelium (Krukenberg's spindle) in addition to radial, spoke like transillumination defects in the mid peripheral iris. This study was conducted to determine the frequency of occurrence of Pigmentary Glaucoma in patients with Pigment Dispersion Syndrome (PDS)...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29074388/functional-assessment-of-the-aqueous-humour-distal-outflow-pathways-in-bovine-eyes-using-time-of-flight-magnetic-resonance-tomography
#12
Thomas Wecker, Christian van Oterendorp, Wilfried Reichardt
The major part of the aqueous humor leaves the eye through the "conventional outflow pathway", consisting of the trabecular meshwork, Schlemm's canal, collector channels, an intrasceral plexus and the episcleral veins. While the trabecular meshwork is well characterized, little is known about anatomical and functional features of the peripheral outflow tract beyond Schlemm's canal. The emergence of minimally-invasive glaucoma surgery directly targeting the outflow resistance in the trabecular meshwork has elicited growing interest in these structures...
October 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29070474/-histological-structure-of-the-trabecular-meshwork-in-the-eyeball-challenging-the-traditional-concept-and-preliminary-findings-in-rabbits-rats-and-mice
#13
Yun Shi, Fan-Qi Zhou, Zhou-Cai Luo, Ying-Hua Chen, Yu Chen, Wei-Ren Dong
OBJECTIVE: To verify that the trabecular meshwork (TM) in the wall of the eyeball consists of smooth muscle fibers instead of collagen fibers or endothelial cells. METHODS: Eighteen fresh eyeballs from 3 rabbits, 3 SD rats and 3 mice were sectioned along the sagittal plane and sliced after paraffin embedding for HE staining, VG staining, Masson staining, α-SMA immunohistochemistry or CD31 immunohistochemistry. These slices were observed under microscope and the structure of the TM was compared with those of scleral collagen fibers, ciliary muscles and endothelial cells...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29068915/ocular-manifestations-of-systemic-amyloidosis
#14
Margaret M Reynolds, Kevin K Veverka, Morie A Gertz, Angela Dispenzieri, Steven R Zeldenrust, Nelson Leung, Jose S Pulido
PURPOSE: To describe ophthalmic manifestations of systemic amyloidosis, a group of devastating conditions. METHODS: A retrospective chart review including patients who had ocular examinations at Mayo Clinic between January 1, 1985, and April 1, 2014, and a diagnosis of light-chain (AL), secondary (AA), or nontransthyretin familial amyloidosis was undertaken. Sixty-eight patients with AL amyloidosis, eight patients with AA amyloidosis, and five patients with nontransthyretin familial amyloidosis were included...
October 24, 2017: Retina
https://www.readbyqxmd.com/read/29050926/-role-of-laser-peripheral-iridotomy-in-pigmentary-glaucoma-and-pigment-dispersion-syndrome-a-review-of-the-literature-french-version
#15
REVIEW
J Buffault, B Leray, A Bouillot, C Baudouin, A Labbé
PURPOSE: Pigment dispersion syndrome (PSD) is characterized by a structural abnormality of the posterior surface of the iris causing contact with the zonular fibers. It can lead to an open-angle glaucoma secondary to pigment dispersion into the trabecular meshwork. Laser peripheral iridotomy (PI) has been proposed as a treatment for pigmentary glaucoma (PG) and pigment dispersion syndrome (PDS) by reducing the dispersion of pigment. The goal of this review was to assess the effects of PI for PSD and PG...
October 16, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29049733/tunneling-nanotubes-are-novel-cellular-structures-that-communicate-signals-between-trabecular-meshwork-cells
#16
Kate E Keller, John M Bradley, Ying Ying Sun, Yong-Feng Yang, Ted S Acott
Purpose: The actin cytoskeleton of trabecular meshwork (TM) cells plays a role in regulating aqueous humor outflow. Many studies have investigated stress fibers, but F-actin also assembles into other supramolecular structures including filopodia. Recently, specialized filopodia called tunneling nanotubes (TNTs) have been described, which communicate molecular signals and organelles directly between cells. Here, we investigate TNT formation by TM cells. Methods: Human TM cells were labeled separately with the fluorescent dyes, DiO and DiD, or with mitochondrial dye...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049729/myocilin-regulates-metalloprotease-2-activity-through-interaction-with-timp3
#17
Myung Kuk Joe, Raquel L Lieberman, Naoki Nakaya, Stanislav I Tomarev
Purpose: To elucidate functions of wild-type myocilin, a secreted glycoprotein associated with glaucoma. Methods: Lysates of mouse eyes were used for immunoprecipitation with affinity-purified antibodies against mouse myocilin. Shotgun proteomic analysis was used for the identification of proteins interacting with myocilin. Colocalization of myocilin and tissue inhibitor of metalloproteinases 3 (TIMP3) in different eye structures was investigated by a multiplex fluorescent in situ hybridization and immunofluorescent labeling with subsequent confocal microscopy...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29038959/the-effect-of-additional-trabecular-aspiration-to-phacoemulsification-and-trabectome-as-a-triple-procedure-in-pseudoexfoliation-glaucoma-a-case-matched-study
#18
R A Widder, J F Jordan, P Kühnrich, J Luebke, G F Roessler, A Anton
BACKGROUND: Trabectome surgery combined with phacoemulsification is effective in lowering (intraocular pressure) IOP in pseudoexfoliation glaucoma. Trabectome surgery usually aims to remove two to four clock hours of the trabecular meshwork. When adding trabecular aspiration, the remaining meshwork can be treated as well, and therefore 360 degrees of the meshwork can be reached. This study was conducted to investigate the additional benefits and risks of adding trabecular aspiration to the combination of phacoemulsification and trabectome as a triple procedure...
October 16, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29030797/corneal-endothelial-changes-following-a-single-session-of-selective-laser-trabeculoplasty-for-pseudoexfoliative-glaucoma
#19
Nurgül Örnek, Kemal Örnek
PURPOSE: To evaluate corneal endothelial cell parameters after a single session of selective laser trabeculoplasty (SLT) in pseudoexfoliative glaucoma (PEG) patients. METHODS: Corneal endothelial cell parameters of 18 PEG patients were compared with 18 healthy subjects following SLT treatment. All patients underwent SLT treatment to 180 degrees of inferior trabecular meshwork. Corneal measurements were performed using specular microscopy (Noncon Robo SP8000, Konan Medical, Hyogo, Japan)...
October 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29026286/intraoperative-optical-coherence-tomography-and-ab-interno-trabecular-meshwork-surgery-with-the-trabectome
#20
Bernd Junker, Jens F Jordan, Carsten Framme, Amelie Pielen
IMPORTANCE: This study is the first description of the use of the intraoperative optical coherence tomography (iOCT) for trabecular meshwork surgery with the Trabectome in a regular clinical setting. BACKGROUND: The aim of this study is to evaluate intraoperatively the immediate success of ab interno trabeculotomy with the Trabectome defined as a removal of the trabecular meshwork. DESIGN: This is a retrospective clinical study performed in the University Eye Hospital, Medical School Hannover...
2017: Clinical Ophthalmology
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