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Trabecular meshwork

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https://www.readbyqxmd.com/read/27878244/microrna%C3%A2-93-is-overexpressed-and-induces-apoptosis-in-glaucoma-trabecular-meshwork-cells
#1
Yansa Wang, Fenghua Li, Shuyun Wang
Glaucoma is an optic neuropathy and a major cause of blindness globally. Trabecular meshwork cells are important in maintaining aqueous humor flow, the dysfunction of which tends to induce glaucoma. As important regulators of gene expression, microRNAs may be crucial in regulating trabecular meshwork cells. The present study aimed to reveal the effect of microRNA‑93 (miR‑93) on glaucoma trabecular meshwork (GTM) cell apoptosis. The expression levels of miR‑93 were compared between human trabecular meshwork (HTM) cells and GTM cells...
November 14, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27820954/aberrant-collagen-composition-of-the-trabecular-meshwork-results-in-reduced-aqueous-humor-drainage-and-elevated-iop-in-mmp-9-null-mice
#2
Lies De Groef, Lien Andries, Anuja Siwakoti, Emiel Geeraerts, Ilse Bollaerts, Lut Noterdaeme, Isabelle Etienne, Anna-Pia Papageorgiou, Ingeborg Stalmans, Johan Billen, Judith A West-Mays, Lieve Moons
Purpose: Homeostatic turnover of the trabecular meshwork extracellular matrix (ECM) is essential to regulate aqueous humor outflow and to maintain intraocular pressure homeostasis. In this study, we evaluated aqueous humor turnover, intraocular pressure, and trabecular meshwork organization in MMP-9 null mice. Methods: Intraocular pressure and aqueous humor turnover were measured in MMP-9 null versus wild-type mice. Morphology of the anterior segment of the eye, with special attention to the structural organization of the trabecular meshwork, was investigated by means of optical coherence tomography, light microscopy, and transmission electron microscopy...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27820874/expression-of-mutant-myocilin-induces-abnormal-intracellular-accumulation-of-selected-extracellular-matrix-proteins-in-the-trabecular-meshwork
#3
Ramesh B Kasetti, Tien N Phan, J Cameron Millar, Gulab S Zode
Purpose: Abnormal accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) is associated with decreased aqueous humor outflow facility and IOP elevation in POAG. Previously, we have developed a transgenic mouse model of POAG (Tg-MYOCY437H) by expressing human mutant myocilin (MYOC), a known genetic cause of POAG. The purpose of this study is to examine whether expression of mutant myocilin leads to reduced outflow facility and abnormal ECM accumulation in Tg-MYOCY437H mice and in cultured human TM cells...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27805318/short-term-results-of-microhook-ab-interno-trabeculotomy-a-novel-minimally-invasive-glaucoma-surgery-in-japanese-eyes-initial-case-series
#4
Masaki Tanito, Ichiya Sano, Yoshifumi Ikeda, Etsuko Fujihara
PURPOSE: To report the first early postoperative results and safety profile after microhook ab interno trabeculotomy (μLOT). METHODS: This initial retrospective observational case series included 24 consecutive glaucomatous eyes of 17 Japanese patients (7 men, 10 women; mean age ± standard deviation, 66.7 ± 17.9 years) who underwent μLOT. The trabeculotomy extent, surgical time, perioperative complications, interventions for complications and additional glaucoma surgeries during the follow-up for more than 3 months were collected by reviewing the medical and surgical records...
November 2, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27803851/effects-of-dexamethasone-and-ha1077-on-actin-cytoskeleton-and-%C3%AE-catenin-in-cultured-human-trabecular-meshwork-cells
#5
Jie Peng, Xiao-Yun Feng, Zi-Meng Ye, Qian Luo, Yi-Lian Cheng, Zheng-Zheng Wu, Chun-Tao Lei, Bo Gong
AIM: To investigate the effects of dexamethasone (DEX) and 1-(5-isoquinolinesulfonyl)-homopiperazine (HA1077) on actin cytoskeleton and β-catenin in cultured human trabecular meshwork (HTM) cells. METHODS: The HTM cells were separated from human eyeball and cultured in vitro. They were divided into control group, DEX (1×10(-6) mol/L) group, HA1077 (3×10(-5) mol/L) group, and DEX (1×10(-6) mol/L) and HA1077 (3×10(-5) mol/L) group. Actin cytoskeleton and β-catenin in HTM cells of the four groups were examined by immunofluorescence and Western blot analyses...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27790380/aqueous-humor-outflow-structure-and-function-imaging-at-the-bench-and-bedside-a-review
#6
Alex S Huang, Chirayu Mohindroo, Robert N Weinreb
Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire conventional aqueous humor outflow (AHO) pathway from the anterior chamber to the episcleral vein. AHO investigation can be divided into structural and functional assessments using different methods. The historical basis for studying the anterior segment of the eye and AHO in glaucoma is discussed...
August 2016: Journal of Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27788183/angle-closure-scoring-system-acss-a-scoring-system-for-stratification-of-angle-closure-disease
#7
Aparna Rao, Debananda Padhy, Sarada Sarangi, Gopinath Das
PURPOSE: To evaluate the angle closure scoring system (ACSS) for stratifying primary angle course disease. METHODS: This observational cross sectional institutional study included patients with primary open angle glaucoma suspects (n = 21) and primary angle closure disease (primary angle closure, PAC, n = 63 and primary angle course glaucoma, PACG, n = 58 (defined by International society of Geographical and Epidemiological Ophthalmology, ISGEO). Two independent examiners blinded to clinical details, graded good quality pre-laser goniophotographs of the patients incorporating quadrants of peripheral anterior synechieae (PAS), non-visibility of posterior trabecular meshwork (PTM) and blotchy pigments (ranging from 1-4 quadrants), iris configuration, angle recess (sum of above depicting ACSSg) and lens thickness/axial length ratio (LT/AL), cup disc ratio and baseline intraocular pressure (IOP) to give total score (ACSSt)...
2016: PloS One
https://www.readbyqxmd.com/read/27783649/mechanism-of-fibronectin-binding-to-human-trabecular-meshwork-exosomes-and-its-modulation-by-dexamethasone
#8
W Michael Dismuke, Mikael Klingeborn, W Daniel Stamer
Exosomes are emerging as important mediators of cell-matrix interactions by means of specific adhesion proteins. Changes in the tissue-specific exosomal protein expression may underlie pathological conditions whereby extracellular matrix turnover and homeostasis is disrupted. Ocular hypertension due to extracellular matrix accumulation in the trabecular meshwork is a hallmark of glucocorticoid-induced glaucoma. In the trabecular meshwork, exosomal fibronectin mediates cell matrix interactions at cellular structures called "invadosomes"...
2016: PloS One
https://www.readbyqxmd.com/read/27775151/collagen-and-collagen-chondroitin-sulfate-scaffolds-with-uniaxially-aligned-pores-for-the-biomimetic-three-dimensional-culture-of-trabecular-meshwork-cells
#9
Matthew Osmond, Sarah M Bernier, Mina B Pantcheva, Melissa D Krebs
Glaucoma is a disease in which damage to the optic nerve leads to progressive, irreversible vision loss. The intraocular pressure (IOP) is the only modifiable risk factor for glaucoma and its lowering is considered a useful strategy for preventing or slowing down the progression of glaucomatous neuropathy. Elevated intraocular pressure associated with glaucoma is due to increased aqueous humor outflow resistance, primarily through the trabecular meshwork (TM) of the eye. Current in vitro models of the trabecular meshwork are oversimplified and do not capture the organized and complex three-dimensional nature of this tissue that consists primarily of collagen and glycoasaminoglycans...
October 24, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27764227/association-between-myopia-biometry-and-occludable-angle-the-jiangning-eye-study
#10
Xiaohong Liu, Hehua Ye, Qi Zhang, Xuan Cai, Wenjing Yu, Siyi Yu, Tianyu Wang, Wuyi Lu, Xiang Li, Peiquan Zhao
BACKGROUND: Myopia subjects usually have long axial lengths and are predisposed to deep anterior chamber depths and open angles. Jiangning eye study is a randomized, population based study in Shanghai to determine whether myopia has an effect on the prevalence of occludable angles. METHODS: A total of 2478 residents aged 50 years and over were randomly selected, and 2044 (82.5%) individuals of them participated in ophthalmic examinations between November 2012 and February 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27746064/melanomalytic-glaucoma-secondary-to-iris-melanoma
#11
S Ajamil Rodanés, C García-Álvarez, M A Saornil Alvarez, F López-Lara, J M Frutos Baraja, M Quiñones
CLINICAL CASE: A 35-year-old male with unilateral ocular hypertension in the right eye (RE). Anterior segment examination of the RE showed a melanotic lesion. Intraocular pressure (IOP) was 40mmHg in RE. Gonioscopy revealed extension into the anterior chamber angle. Excisional biopsy was performed and consistent with iris melanoma and secondary melanomalytic glaucoma. Brachytherapy was performed as adjuvant therapy. DISCUSSION: In patients presenting with unilateral glaucoma and increased pigmentation in the trabecular meshwork, it is crucial to perform imaging studies...
October 13, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27726963/changes-in-anterior-segment-morphology-and-predictors-of-angle-widening-after-laser-iridotomy-in-south-indian-eyes
#12
Nazlee Zebardast, Srinivasan Kavitha, Palaniswamy Krishnamurthy, David S Friedman, Monisha E Nongpiur, Tin Aung, Harry A Quigley, Pradeep Y Ramulu, Rengaraj Venkatesh
PURPOSE: To compare anterior segment optical coherence tomography (ASOCT) angle morphology before and after laser peripheral iridotomy (LPI) in a cohort of South Indian subjects with primary angle-closure suspect (PACS) or primary angle-closure/primary angle-closure glaucoma (PAC/PACG) and to examine baseline parameters associated with angle widening. DESIGN: Prospective observational study. PARTICIPANTS: A total of 244 subjects aged ≥30 years with PACS or PAC/PACG in at least 1 eye...
October 7, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27679948/age-related-changes-in-bone-architecture
#13
Vincenzo Giordano, José Sérgio Franco, Hilton Augusto Koch, Pedro José Labronici, Robinson Esteves S Pires, Ney Pecegueiro DO Amaral
OBJECTIVE: : to evaluate the histologic and morphometric characteristics of bone biopsies of the anterior iliac crest of patients of different age groups. METHODS: : we studied 30 bone samples from the iliac crest, using brightfield optical microscopy. We divided the samples by donors' age groups in three groups: Group 1 (n = 10), subjects aged between 25 and 39 years; Group 2 (n = 10), subjects aged between 40 and 64 years; Group 3 (n = 10), individuals aged 65 years and over...
July 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27666911/biventricular-non-compaction-cardiomyopathy
#14
S B Gupta, Enrica D'Souza
Left ventricular non-compaction (spongy myocardium) is one of the most misclassified cardiomyopathies. It is characterised by an excessively prominent trabecular meshwork of myocardium and deep intertrabecular myocardium due to an arrest in the compaction process of the myocardial fibres. It could be isolated i.e. without any other structural heart defects or associated with congenital heart defects. The clinical manifestations are variable heart failure, arrhythmia, thromboembolic phenomena depending on extent of non-compaction of cardiac segment...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27661987/congenital-glaucoma-and-charge-syndrome-a-case-report
#15
Matthew D Benson, Imran Jivraj, Karim F Damji, Carlos E Solarte
PURPOSE: To report a rare case of congenital glaucoma in a patient with CHARGE syndrome, present gonioscopic photographs, and explore mechanisms of disease that may account for this association. PATIENTS AND METHODS: We describe a 35-week-old girl with previously diagnosed CHARGE syndrome who presented with corneal edema, buphthalmos, and elevated intraocular pressure in the left eye. She was subsequently diagnosed with congenital glaucoma and started on topical and oral therapy...
September 21, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27636593/transscleral-selective-laser-trabeculoplasty-without-a-gonioscopy-lens
#16
Noa Geffen, Shay Ofir, Avner Belkin, Fani Segev, Yaniv Barkana, Audrey Kaplan Messas, Ehud I Assia, Michael Belkin
PURPOSE OF THE STUDY: The purpose of the study was to investigate results of selective laser trabeculoplasty (SLT) performed directly on the sclera without a gonioscopy lens. DESIGN: Interventional case series, prospective, randomized, masked, controlled clinical trial. METHODS: Setting: Meir Medical Center, Kfar-Saba, Israel. STUDY POPULATION: Adults with uncontrolled primary open angle or pseudoexfoliation glaucoma randomized into 2 groups...
September 15, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27631351/two-photon-microscopy-of-the-mouse-peripheral-cornea-ex-vivo
#17
Jun Ho Lee, Ki Hean Kim, Seunghun Lee, Hyerin Jeong, Myoung Joon Kim
PURPOSE: To investigate the 3-dimensional (3D) cell and extracellular matrix (ECM) structure of mouse peripheral corneas in normal and corneal neovascularization tissues using 2-photon microscopy (TPM) based on both intrinsic and extrinsic moxifloxacin contrasts. METHODS: Peripheral corneas in freshly enucleated mouse eyes were imaged by TPM based on both intrinsic and extrinsic contrasts. Intrinsic autofluorescence and second harmonic generation were used to image cells and ECM collagen, respectively...
November 2016: Cornea
https://www.readbyqxmd.com/read/27609553/right-atrial-deformation-analysis-in-isolated-left-ventricular-noncompaction-insights-from-the-three-dimensional-speckle-tracking-echocardiographic-magyar-path-study
#18
Attila Nemes, Péter Domsik, Anita Kalapos, Henriette Gavallér, Mónika Oszlánczi, Tamás Forster
OBJECTIVE: Isolated left ventricular noncompaction (ILVNC) is a rare cardiomyopathy characterized by a prominent trabecular meshwork and deep intertrabecular recesses. The present study aimed to examine right atrial (RA) volumes, volume-based functional properties and strains by three-dimensional speckle-tracking echocardiography (3DSTE) in ILVNC patients. METHODS: The study group consisted of 13 patients with ILVNC (mean age: 54.6±14.1 years, six male) and 23 healthy age- and gender-matched volunteers (mean age: 50...
October 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27607419/influence-of-exercise-on-intraocular-pressure-schlemm-s-canal-and-the-trabecular-meshwork
#19
Xiaoqin Yan, Mu Li, Yinwei Song, Jingmin Guo, Yin Zhao, Wei Chen, Hong Zhang
PURPOSE: We aimed to assess the changes in IOP, Schlemm's canal (SC), and the trabecular meshwork (TM) in healthy individuals after exercise. METHODS: The area and perimeter of SC, TM thickness, IOP, pupil diameter, blood pressure (BP), heart rate, and plasma catecholamine concentrations were measured in 29 young healthy individuals before and after exercise by jogging for 20 minutes. The TM and SC in the superior, inferior, nasal, and temporal regions were evaluated by 80-MHz ultrasound biomicroscopy...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27598990/oct-study-of-mechanical-properties-associated-with-trabecular-meshwork-and-collector-channel-motion-in-human-eyes
#20
Chen Xin, Murray Johnstone, Ningli Wang, Ruikang K Wang
We report the use of a high-resolution optical coherence tomography (OCT) imaging platform to identify and quantify pressure-dependent aqueous outflow system (AOS) tissue relationships and to infer mechanical stiffness through examination of tissue properties in ex vivo human eyes. Five enucleated human eyes are included in this study, with each eye prepared with four equal-sized quadrants, each encompassing 90 degrees of the limbal circumference. In radial limbal segments perfusion pressure within Schlemm's canal (SC) is controlled by means of a perfusion cannula inserted into the canal lumen, while the other end of the cannula leads to a reservoir at a height that can control the pressure in the cannula...
2016: PloS One
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