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https://www.readbyqxmd.com/read/28342824/development-of-car-t-cells-designed-to-improve-antitumor-efficacy-and-safety
#1
REVIEW
Janneke E Jaspers, Renier J Brentjens
Chimeric antigen receptor (CAR) T cell therapy has shown promising efficacy against hematologic malignancies. Antitumor activity of CAR T cells, however, needs to be improved to increase therapeutic efficacy in both hematologic and solid cancers. Limitations to overcome are 'on-target, off-tumor' toxicity, antigen escape, short CAR T cell persistence, little expansion, trafficking to the tumor and inhibition of T cell activity by an inhibitory tumor microenvironment. Here we will discuss how optimizing the design of CAR T cells through genetic engineering addresses these limitations and improves the antitumor efficacy of CAR T cell therapy in pre-clinical models...
March 22, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28331617/current-approaches-to-increase-car-t-cell-potency-in-solid-tumors-targeting-the-tumor-microenvironment
#2
REVIEW
Irene Scarfò, Marcela V Maus
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28331616/ex-vivo-akt-inhibition-promotes-the-generation-of-potent-cd19car-t-cells-for-adoptive-immunotherapy
#3
Ryan Urak, Miriam Walter, Laura Lim, ChingLam W Wong, Lihua E Budde, Sandra Thomas, Stephen J Forman, Xiuli Wang
BACKGROUND: Insufficient persistence and effector function of chimeric antigen receptor (CAR)-redirected T cells have been challenging issues for adoptive T cell therapy. Generating potent CAR T cells is of increasing importance in the field. Studies have demonstrated the importance of the Akt pathway in the regulation of T cell differentiation and memory formation. We now investigate whether inhibition of Akt signaling during ex vivo expansion of CAR T cells can promote the generation of CAR T cells with enhanced antitumor activity following adoptive therapy in a murine leukemia xenograft model...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28331433/search-for-triboson-formula-see-text-production-in-pp-collisions-at-formula-see-text-%C3%A2-formula-see-text-with-the-atlas-detector
#4
M Aaboud, G Aad, B Abbott, J Abdallah, O Abdinov, B Abeloos, R Aben, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, R Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adamczyk, D L Adams, J Adelman, S Adomeit, T Adye, A A Affolder, T Agatonovic-Jovin, J Agricola, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, H Akerstedt, T P A Åkesson, A V Akimov, G L Alberghi, J Albert, S Albrand, M J Alconada Verzini, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, B Ali, M Aliev, G Alimonti, J Alison, S P Alkire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, K Amako, Y Amaral Coutinho, C Amelung, D Amidei, S P Amor Dos Santos, A Amorim, S Amoroso, G Amundsen, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, G Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, P Anger, A Angerami, F Anghinolfi, A V Anisenkov, N Anjos, A Annovi, C Antel, M Antonelli, A Antonov, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, A T H Arce, F A Arduh, J-F Arguin, S Argyropoulos, M Arik, A J Armbruster, L J Armitage, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, B Åsman, L Asquith, K Assamagan, R Astalos, M Atkinson, N B Atlay, K Augsten, G Avolio, B Axen, M K Ayoub, G Azuelos, M A Baak, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, M Backhaus, P Bagiacchi, P Bagnaia, Y Bai, J T Baines, O K Baker, E M Baldin, P Balek, T Balestri, F Balli, W K Balunas, E Banas, Sw Banerjee, A A E Bannoura, L Barak, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, T Barklow, N Barlow, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H P Beck, K Becker, M Becker, M Beckingham, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, L J Beemster, T A Beermann, M Begel, J K Behr, C Belanger-Champagne, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, O Beltramello, N L Belyaev, O Benary, D Benchekroun, M Bender, K Bendtz, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, J Beringer, S Berlendis, N R Bernard, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, F Bertolucci, I A Bertram, C Bertsche, D Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, C Betancourt, A Bethani, S Bethke, A J Bevan, R M Bianchi, L Bianchini, M Bianco, O Biebel, D Biedermann, R Bielski, N V Biesuz, M Biglietti, J Bilbao De Mendizabal, T R V Billoud, H Bilokon, M Bindi, S Binet, A Bingul, C Bini, S Biondi, T Bisanz, D M Bjergaard, C W Black, J E Black, K M Black, D Blackburn, R E Blair, J-B Blanchard, T Blazek, I Bloch, C Blocker, A Blue, W Blum, U Blumenschein, S Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, M Boehler, D Boerner, J A Bogaerts, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, M Bomben, M Bona, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, K Bos, D Boscherini, M Bosman, J D Bossio Sola, J Boudreau, J Bouffard, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, J Bracinik, A Brandt, G Brandt, O Brandt, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, T M Bristow, D Britton, D Britzger, F M Brochu, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, J Brosamer, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, R Bruneliere, A Bruni, G Bruni, L S Bruni, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, H Burckhart, S Burdin, C D Burgard, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, E Busato, D Büscher, V Büscher, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, S Cabrera Urbán, D Caforio, V M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, A Canepa, M Cano Bret, J Cantero, T Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F Cardillo, I Carli, T Carli, G Carlino, L Carminati, S Caron, E Carquin, G D Carrillo-Montoya, J R Carter, J Carvalho, D Casadei, M P Casado, M Casolino, D W Casper, E Castaneda-Miranda, R Castelijn, A Castelli, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, F Ceradini, L Cerda Alberich, B C Cerio, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, M Cerv, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, Y L Chan, P Chang, J D Chapman, D G Charlton, A Chatterjee, C C Chau, C A Chavez Barajas, S Che, S Cheatham, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, H Chen, K Chen, S Chen, S Chen, X Chen, Y Chen, H C Cheng, H J Cheng, Y Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, V Chernyatin, E Cheu, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, M V Chizhov, K Choi, A R Chomont, S Chouridou, B K B Chow, V Christodoulou, D Chromek-Burckhart, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, G Ciapetti, A K Ciftci, D Cinca, V Cindro, I A Cioara, C Ciocca, A Ciocio, F Cirotto, Z H Citron, M Citterio, M Ciubancan, A Clark, B L Clark, M R Clark, P J Clark, R N Clarke, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Colasurdo, B Cole, A P Colijn, J Collot, T Colombo, G Compostella, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, V Consorti, S Constantinescu, G Conti, F Conventi, M Cooke, B D Cooper, A M Cooper-Sarkar, K J R Cormier, T Cornelissen, M Corradi, F Corriveau, A Cortes-Gonzalez, G Cortiana, G Costa, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, K Cranmer, S J Crawley, G Cree, S Crépé-Renaudin, F Crescioli, W A Cribbs, M Crispin Ortuzar, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, J Cummings, M Curatolo, J Cúth, H Czirr, P Czodrowski, G D'amen, S D'Auria, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, N P Dang, A C Daniells, N S Dann, M Danninger, M Dano Hoffmann, V Dao, G Darbo, S Darmora, J Dassoulas, A Dattagupta, W Davey, C David, T Davidek, M Davies, P Davison, E Dawe, I Dawson, K De, R de Asmundis, A De Benedetti, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, A De Santo, J B De Vivie De Regie, W J Dearnaley, R Debbe, C Debenedetti, D V Dedovich, N Dehghanian, I Deigaard, M Del Gaudio, J Del Peso, T Del Prete, D Delgove, F Deliot, C M Delitzsch, A Dell'Acqua, L Dell'Asta, M Dell'Orso, M Della Pietra, D Della Volpe, M Delmastro, P A Delsart, D A DeMarco, S Demers, M Demichev, A Demilly, S P Denisov, D Denysiuk, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, P O Deviveiros, A Dewhurst, S Dhaliwal, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, B Di Girolamo, B Di Micco, R Di Nardo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, M A Diaz, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, P Dita, S Dita, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, D Dobos, M Dobre, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, S Donati, P Dondero, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, M Dris, Y Du, J Duarte-Campderros, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, A Chr Dudder, E M Duffield, L Duflot, M Dührssen, M Dumancic, M Dunford, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, M Dyndal, C Eckardt, K M Ecker, R C Edgar, N C Edwards, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, V Ellajosyula, M Ellert, S Elles, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, O C Endner, J S Ennis, J Erdmann, A Ereditato, G Ernis, J Ernst, M Ernst, S Errede, E Ertel, M Escalier, H Esch, C Escobar, B Esposito, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, G Facini, R M Fakhrutdinov, S Falciano, R J Falla, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, C Farina, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, S Feigl, L Feligioni, C Feng, E J Feng, H Feng, A B Fenyuk, L Feremenga, P Fernandez Martinez, S Fernandez Perez, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, A Ferretto Parodi, F Fiedler, A Filipčič, M Filipuzzi, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, A Firan, A Fischer, C Fischer, J Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, G T Fletcher, R R M Fletcher, T Flick, L R Flores Castillo, M J Flowerdew, G T Forcolin, A Formica, A Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, D Freeborn, S M Fressard-Batraneanu, F Friedrich, D Froidevaux, J A Frost, C Fukunaga, E Fullana Torregrosa, T Fusayasu, J Fuster, C Gabaldon, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, S Gadomski, G Gagliardi, L G Gagnon, P Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, K K Gan, J Gao, Y Gao, Y S Gao, F M Garay Walls, C García, J E García Navarro, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, A Gascon Bravo, K Gasnikova, C Gatti, A Gaudiello, G Gaudio, L Gauthier, I L Gavrilenko, C Gay, G Gaycken, E N Gazis, Z Gecse, C N P Gee, Ch Geich-Gimbel, M Geisen, M P Geisler, K Gellerstedt, C Gemme, M H Genest, C Geng, S Gentile, C Gentsos, S George, D Gerbaudo, A Gershon, S Ghasemi, M Ghneimat, B Giacobbe, S Giagu, P Giannetti, B Gibbard, S M Gibson, M Gignac, M Gilchriese, T P S Gillam, D Gillberg, G Gilles, D M Gingrich, N Giokaris, M P Giordani, F M Giorgi, F M Giorgi, P F Giraud, P Giromini, D Giugni, F Giuli, C Giuliani, M Giulini, B K Gjelsten, S Gkaitatzis, I Gkialas, E L Gkougkousis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Gonçalo, J Goncalves Pinto Firmino Da Costa, G Gonella, L Gonella, A Gongadze, S González de la Hoz, G Gonzalez Parra, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, I Gorelov, B Gorini, E Gorini, A Gorišek, E Gornicki, A T Goshaw, C Gössling, M I Gostkin, C R Goudet, D Goujdami, A G Goussiou, N Govender, E Gozani, L Graber, I Grabowska-Bold, P O J Gradin, P Grafström, J Gramling, E Gramstad, S Grancagnolo, V Gratchev, P M Gravila, H M Gray, E Graziani, Z D Greenwood, C Grefe, K Gregersen, I M Gregor, P Grenier, K Grevtsov, J Griffiths, A A Grillo, K Grimm, S Grinstein, Ph Gris, J-F Grivaz, S Groh, J P Grohs, E Gross, J Grosse-Knetter, G C Grossi, Z J Grout, L Guan, W Guan, J Guenther, F Guescini, D Guest, O Gueta, E Guido, T Guillemin, S Guindon, U Gul, C Gumpert, J Guo, Y Guo, R Gupta, S Gupta, G Gustavino, P Gutierrez, N G Gutierrez Ortiz, C Gutschow, C Guyot, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, A 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This paper reports a search for triboson [Formula: see text] production in two decay channels ([Formula: see text] and [Formula: see text] with [Formula: see text]) in proton-proton collision data corresponding to an integrated luminosity of 20.3 [Formula: see text] at a centre-of-mass energy of 8 [Formula: see text] with the ATLAS detector at the Large Hadron Collider. Events with exactly three charged leptons, or two leptons with the same electric charge in association with two jets, are selected. The total number of events observed in data is consistent with the Standard Model (SM) predictions...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28331429/measurement-of-the-prompt-j-formula-see-text-pair-production-cross-section-in-pp-collisions-at-formula-see-text-%C3%A2-tev-with-the-atlas-detector
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A Lopez Solis, J Lorenz, N Lorenzo Martinez, M Losada, P J Lösel, X Lou, A Lounis, J Love, P A Love, H Lu, N Lu, H J Lubatti, C Luci, A Lucotte, C Luedtke, F Luehring, W Lukas, L Luminari, O Lundberg, B Lund-Jensen, P M Luzi, D Lynn, R Lysak, E Lytken, V Lyubushkin, H Ma, L L Ma, Y Ma, G Maccarrone, A Macchiolo, C M Macdonald, B Maček, J Machado Miguens, D Madaffari, R Madar, H J Maddocks, W F Mader, A Madsen, J Maeda, S Maeland, T Maeno, A Maevskiy, E Magradze, J Mahlstedt, C Maiani, C Maidantchik, A A Maier, T Maier, A Maio, S Majewski, Y Makida, N Makovec, B Malaescu, Pa Malecki, V P Maleev, F Malek, U Mallik, D Malon, C Malone, C Malone, S Maltezos, S Malyukov, J Mamuzic, G Mancini, L Mandelli, I Mandić, J Maneira, L Manhaes de Andrade Filho, J Manjarres Ramos, A Mann, A Manousos, B Mansoulie, J D Mansour, R Mantifel, M Mantoani, S Manzoni, L Mapelli, G Marceca, L March, G Marchiori, M Marcisovsky, M Marjanovic, D E Marley, F Marroquim, S P Marsden, Z Marshall, S Marti-Garcia, B Martin, T A Martin, V J Martin, B Martin Dit Latour, M Martinez, V I Martinez Outschoorn, S Martin-Haugh, V S Martoiu, A C Martyniuk, A Marzin, L Masetti, T Mashimo, R Mashinistov, J Masik, A L Maslennikov, I Massa, L Massa, P Mastrandrea, A Mastroberardino, T Masubuchi, P Mättig, J Mattmann, J Maurer, S J Maxfield, D A Maximov, R Mazini, I Maznas, S M Mazza, N C Mc Fadden, G Mc Goldrick, S P Mc Kee, A McCarn, R L McCarthy, T G McCarthy, L I McClymont, E F McDonald, J A Mcfayden, G Mchedlidze, S J McMahon, R A McPherson, M Medinnis, S Meehan, S Mehlhase, A Mehta, K Meier, C Meineck, B Meirose, D Melini, B R Mellado Garcia, M Melo, F Meloni, S B Menary, L Meng, X T Meng, A Mengarelli, S Menke, E Meoni, S Mergelmeyer, P Mermod, L Merola, C Meroni, F S Merritt, A Messina, J Metcalfe, A S Mete, C Meyer, C Meyer, J-P Meyer, J Meyer, H Meyer Zu Theenhausen, F Miano, R P Middleton, S Miglioranzi, L Mijović, G Mikenberg, M Mikestikova, M Mikuž, M Milesi, A Milic, D W Miller, C Mills, A Milov, D A Milstead, A A Minaenko, Y Minami, I A Minashvili, A I Mincer, B Mindur, M Mineev, Y Minegishi, Y Ming, L M Mir, K P Mistry, T Mitani, J Mitrevski, V A Mitsou, A Miucci, P S Miyagawa, A Mizukami, J U Mjörnmark, M Mlynarikova, T Moa, K Mochizuki, P Mogg, S Mohapatra, S Molander, R Moles-Valls, R Monden, M C Mondragon, K Mönig, J Monk, E Monnier, A Montalbano, J Montejo Berlingen, F Monticelli, S Monzani, R W Moore, N Morange, D Moreno, M Moreno Llácer, P Morettini, S Morgenstern, D Mori, T Mori, M Morii, M Morinaga, V Morisbak, S Moritz, A K Morley, G Mornacchi, J D Morris, S S Mortensen, L Morvaj, P Moschovakos, M Mosidze, H J Moss, J Moss, K Motohashi, R Mount, E Mountricha, E J W Moyse, S Muanza, R D Mudd, F Mueller, J Mueller, R S P Mueller, T Mueller, D Muenstermann, P Mullen, G A Mullier, F J Munoz Sanchez, J A Murillo Quijada, W J Murray, H Musheghyan, M Muškinja, A G Myagkov, M Myska, B P Nachman, O Nackenhorst, K Nagai, R Nagai, K Nagano, Y Nagasaka, K Nagata, M Nagel, E Nagy, A M Nairz, Y Nakahama, K Nakamura, T Nakamura, I Nakano, R F Naranjo Garcia, R Narayan, D I Narrias Villar, I Naryshkin, T Naumann, G Navarro, R Nayyar, H A Neal, P Yu Nechaeva, T J Neep, A Negri, M Negrini, S Nektarijevic, C Nellist, A Nelson, S Nemecek, P Nemethy, A A Nepomuceno, M Nessi, M S Neubauer, M Neumann, R M Neves, P Nevski, P R Newman, D H Nguyen, T Nguyen Manh, R B Nickerson, R Nicolaidou, J Nielsen, A Nikiforov, V Nikolaenko, I Nikolic-Audit, K Nikolopoulos, J K Nilsen, P Nilsson, Y Ninomiya, A Nisati, R Nisius, T Nobe, M Nomachi, I Nomidis, T Nooney, S Norberg, M Nordberg, N Norjoharuddeen, O Novgorodova, S Nowak, M Nozaki, L Nozka, K Ntekas, E Nurse, F Nuti, F O'grady, D C O'Neil, A A O'Rourke, V O'Shea, F G Oakham, H Oberlack, T Obermann, J Ocariz, A Ochi, I Ochoa, J P Ochoa-Ricoux, S Oda, S Odaka, H Ogren, A Oh, S H Oh, C C Ohm, H Ohman, H Oide, H Okawa, Y Okumura, T Okuyama, A Olariu, L F Oleiro Seabra, S A Olivares Pino, D Oliveira Damazio, A Olszewski, J 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D Peshekhonov, K Peters, R F Y Peters, B A Petersen, T C Petersen, E Petit, A Petridis, C Petridou, P Petroff, E Petrolo, M Petrov, F Petrucci, N E Pettersson, A Peyaud, R Pezoa, P W Phillips, G Piacquadio, E Pianori, A Picazio, E Piccaro, M Piccinini, M A Pickering, R Piegaia, J E Pilcher, A D Pilkington, A W J Pin, M Pinamonti, J L Pinfold, A Pingel, S Pires, H Pirumov, M Pitt, L Plazak, M-A Pleier, V Pleskot, E Plotnikova, D Pluth, R Poettgen, L Poggioli, D Pohl, G Polesello, A Poley, A Policicchio, R Polifka, A Polini, C S Pollard, V Polychronakos, K Pommès, L Pontecorvo, B G Pope, G A Popeneciu, A Poppleton, S Pospisil, K Potamianos, I N Potrap, C J Potter, C T Potter, G Poulard, J Poveda, V Pozdnyakov, M E Pozo Astigarraga, P Pralavorio, A Pranko, S Prell, D Price, L E Price, M Primavera, S Prince, K Prokofiev, F Prokoshin, S Protopopescu, J Proudfoot, M Przybycien, D Puddu, M Purohit, P Puzo, J Qian, G Qin, Y Qin, A Quadt, W B Quayle, M Queitsch-Maitland, D Quilty, S Raddum, V 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Schacht, B M Schachtner, D Schaefer, L Schaefer, R Schaefer, J Schaeffer, S Schaepe, S Schaetzel, U Schäfer, A C Schaffer, D Schaile, R D Schamberger, V Scharf, V A Schegelsky, D Scheirich, M Schernau, C Schiavi, S Schier, C Schillo, M Schioppa, S Schlenker, K R Schmidt-Sommerfeld, K Schmieden, C Schmitt, S Schmitt, S Schmitz, B Schneider, U Schnoor, L Schoeffel, A Schoening, B D Schoenrock, E Schopf, M Schott, J F P Schouwenberg, J Schovancova, S Schramm, M Schreyer, N Schuh, A Schulte, M J Schultens, H-C Schultz-Coulon, H Schulz, M Schumacher, B A Schumm, Ph Schune, A Schwartzman, T A Schwarz, H Schweiger, Ph Schwemling, R Schwienhorst, J Schwindling, T Schwindt, G Sciolla, F Scuri, F Scutti, J Searcy, P Seema, S C Seidel, A Seiden, F Seifert, J M Seixas, G Sekhniaidze, K Sekhon, S J Sekula, D M Seliverstov, N Semprini-Cesari, C Serfon, L Serin, L Serkin, M Sessa, R Seuster, H Severini, T Sfiligoj, F Sforza, A Sfyrla, E Shabalina, N W Shaikh, L Y Shan, R Shang, J T Shank, M Shapiro, P B Shatalov, K Shaw, S M Shaw, A Shcherbakova, C Y Shehu, P Sherwood, L Shi, S Shimizu, C O Shimmin, M Shimojima, S Shirabe, M Shiyakova, A Shmeleva, D Shoaleh Saadi, M J Shochet, S Shojaii, D R Shope, S Shrestha, E Shulga, M A Shupe, P Sicho, A M Sickles, P E Sidebo, E Sideras Haddad, O Sidiropoulou, D Sidorov, A Sidoti, F Siegert, Dj Sijacki, J Silva, S B Silverstein, V Simak, Lj Simic, S Simion, E Simioni, B Simmons, D Simon, M Simon, P Sinervo, N B Sinev, M Sioli, G Siragusa, S Yu Sivoklokov, J Sjölin, M B Skinner, H P Skottowe, P Skubic, M Slater, T Slavicek, M Slawinska, K Sliwa, R Slovak, V Smakhtin, B H Smart, L Smestad, J Smiesko, S Yu Smirnov, Y Smirnov, L N Smirnova, O Smirnova, J W Smith, M N K Smith, R W Smith, M Smizanska, K Smolek, A A Snesarev, I M Snyder, S Snyder, R Sobie, F Socher, A Soffer, D A Soh, G Sokhrannyi, C A Solans Sanchez, M Solar, E Yu Soldatov, U Soldevila, A A Solodkov, A Soloshenko, O V Solovyanov, V Solovyev, P Sommer, H Son, H Y Song, A Sood, A Sopczak, V Sopko, V Sorin, D Sosa, C L Sotiropoulou, R Soualah, A M Soukharev, D South, B C Sowden, S Spagnolo, M Spalla, M Spangenberg, F Spanò, D Sperlich, F Spettel, R Spighi, G Spigo, L A Spiller, M Spousta, R D St Denis, A Stabile, R Stamen, S Stamm, E Stanecka, R W Stanek, C Stanescu, M Stanescu-Bellu, M M Stanitzki, S Stapnes, E A Starchenko, G H Stark, J Stark, P Staroba, P Starovoitov, S Stärz, R Staszewski, P Steinberg, B Stelzer, H J Stelzer, O Stelzer-Chilton, H Stenzel, G A Stewart, J A Stillings, M C Stockton, M Stoebe, G Stoicea, P Stolte, S Stonjek, A R Stradling, A Straessner, M E Stramaglia, J Strandberg, S Strandberg, A Strandlie, M Strauss, P Strizenec, R Ströhmer, D M Strom, R Stroynowski, A Strubig, S A Stucci, B Stugu, N A Styles, D Su, J Su, S Suchek, Y Sugaya, M Suk, V V Sulin, S Sultansoy, T Sumida, S Sun, X Sun, J E Sundermann, K Suruliz, C J E Suster, M R Sutton, S Suzuki, M Svatos, M Swiatlowski, S P Swift, I Sykora, T Sykora, D Ta, C Taccini, K Tackmann, J Taenzer, A Taffard, R Tafirout, N Taiblum, H Takai, R Takashima, T Takeshita, Y Takubo, M Talby, A A Talyshev, K G Tan, J Tanaka, M Tanaka, R Tanaka, S Tanaka, R Tanioka, B B Tannenwald, S Tapia Araya, S Tapprogge, S Tarem, G F Tartarelli, P Tas, M Tasevsky, T Tashiro, E Tassi, A Tavares Delgado, Y Tayalati, A C Taylor, G N Taylor, P T E Taylor, W Taylor, F A Teischinger, P Teixeira-Dias, K K Temming, D Temple, H Ten Kate, P K Teng, J J Teoh, F Tepel, S Terada, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, T Theveneaux-Pelzer, J P Thomas, J Thomas-Wilsker, P D Thompson, A S Thompson, L A Thomsen, E Thomson, M J Tibbetts, R E Ticse Torres, V O Tikhomirov, Yu A Tikhonov, S Timoshenko, P Tipton, S Tisserant, K Todome, T Todorov, S Todorova-Nova, J Tojo, S Tokár, K Tokushuku, E Tolley, L Tomlinson, M Tomoto, L Tompkins, K Toms, B Tong, P Tornambe, E Torrence, H Torres, E Torró Pastor, J Toth, F Touchard, D R Tovey, T Trefzger, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, A Trofymov, C Troncon, M Trottier-McDonald, M Trovatelli, L Truong, M Trzebinski, A Trzupek, J C-L Tseng, P V Tsiareshka, G Tsipolitis, N Tsirintanis, S Tsiskaridze, V Tsiskaridze, E G Tskhadadze, K M Tsui, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, Y Tu, A Tudorache, V Tudorache, T T Tulbure, A N Tuna, S A Tupputi, S Turchikhin, D Turgeman, I Turk Cakir, R Turra, P M Tuts, G Ucchielli, I Ueda, M Ughetto, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, C Unverdorben, J Urban, P Urquijo, P Urrejola, G Usai, J Usui, L Vacavant, V Vacek, B Vachon, C Valderanis, E Valdes Santurio, N Valencic, S Valentinetti, A Valero, L Valery, S Valkar, J A Valls Ferrer, W Van Den Wollenberg, P C Van Der Deijl, H van der Graaf, N van Eldik, P van Gemmeren, J Van Nieuwkoop, I van Vulpen, M C van Woerden, M Vanadia, W Vandelli, R Vanguri, A Vaniachine, P Vankov, G Vardanyan, R Vari, E W Varnes, T Varol, D Varouchas, A Vartapetian, K E Varvell, J G Vasquez, G A Vasquez, F Vazeille, T Vazquez Schroeder, J Veatch, V Veeraraghavan, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, A Venturini, V Vercesi, M Verducci, W Verkerke, J C Vermeulen, A Vest, M C Vetterli, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, C Vittori, I Vivarelli, S Vlachos, M Vlasak, M Vogel, P Vokac, G Volpi, M Volpi, H von der Schmitt, E von Toerne, V Vorobel, K Vorobev, M Vos, R Voss, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, R Vuillermet, I Vukotic, P Wagner, W Wagner, H Wahlberg, S Wahrmund, J Wakabayashi, J Walder, R Walker, W Walkowiak, V Wallangen, C Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, K Wang, R Wang, S M Wang, T Wang, W Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, S Webb, M S Weber, S W Weber, S A Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, C Weiser, H Weits, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, J Wetter, K Whalen, N L Whallon, A M Wharton, A White, M J White, R White, D Whiteson, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, F Winklmeier, O J Winston, B T Winter, M Wittgen, T M H Wolf, R Wolff, M W Wolter, H Wolters, S D Worm, B K Wosiek, J Wotschack, M J Woudstra, K W Wozniak, M Wu, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, D Xu, L Xu, B Yabsley, S Yacoob, D Yamaguchi, Y Yamaguchi, A Yamamoto, S Yamamoto, T Yamanaka, K Yamauchi, Y Yamazaki, Z Yan, H Yang, H Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, E Yildirim, K Yorita, R Yoshida, K Yoshihara, C Young, C J S Young, S Youssef, D R Yu, J Yu, J M Yu, J Yu, L Yuan, S P Y Yuen, I Yusuff, B Zabinski, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, A Zaman, S Zambito, L Zanello, D Zanzi, C Zeitnitz, M Zeman, A Zemla, J C Zeng, Q Zeng, O Zenin, T Ženiš, D Zerwas, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, R Zhang, R Zhang, X Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zhong, B Zhou, C Zhou, L Zhou, L Zhou, M Zhou, N Zhou, C G Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, A Zibell, D Zieminska, N I Zimine, C Zimmermann, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, M Zur Nedden, L Zwalinski
The production of two prompt [Formula: see text] mesons, each with transverse momenta [Formula: see text] GeV and rapidity [Formula: see text], is studied using a sample of proton-proton collisions at [Formula: see text] TeV, corresponding to an integrated luminosity of 11.4 fb[Formula: see text] collected in 2012 with the ATLAS detector at the LHC. The differential cross-section, assuming unpolarised [Formula: see text] production, is measured as a function of the transverse momentum of the lower-[Formula: see text] [Formula: see text] meson, di-[Formula: see text] [Formula: see text] and mass, the difference in rapidity between the two [Formula: see text] mesons, and the azimuthal angle between the two [Formula: see text] mesons...
2017: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/28330372/car-t-cell-therapy-progress-and-prospects
#6
Olivia Wilkins, Allison May Keeler, Terence R Flotte
Lentivirus-mediated transduction of autologous T-cells with a chimeric antigen receptor (CAR) to confer a desired epitope-specificity as a targeted immunotherapy for cancer has been among the first human gene therapy techniques to demonstrate widespread therapeutic efficacy. Other approaches to using gene therapy to enhance anti-tumor immunity have been less specific and less effective. These included amplification, marking, and cytokine transduction of tumor infiltrating lymphocytes (TIL), recombinant virus-based expression of tumor antigens as a tumor vaccine, and transduction of antigen-presenting cells (APCs) with tumor antigens...
March 23, 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/28325750/molecular-pathways-evaluating-the-potential-for-b7-h4-as-an-immunoregulatory-target
#7
Heather L MacGregor, Pamela S Ohashi
With the clinical success of CTLA-4 and PD-1 blockade in treating malignancies, there is tremendous interest in finding new ways to augment anti-tumor responses by targeting other inhibitory molecules. In this review, we describe one such molecule. B7-H4, a member of the B7 family of immunoregulatory proteins, inhibits T cell proliferation and cytokine production through ligation of an unknown receptor expressed by activated T cells. Notably, B7-H4 protein expression is observed in a high proportion of patients' tumors across a wide variety of malignancies...
March 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28325715/crispr-meets-car-t-cell-therapy
#8
(no author information available yet)
Using CRISPR/Cas9 technology, researchers have devised a method to deliver a CAR gene to a specific locus, TRAC, in T cells. This targeted approach yielded therapeutic cells that were more potent even at low doses; in a mouse model of acute lymphoblastic leukemia, they outperformed CAR T cells created with a randomly integrating retroviral vector.
March 21, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28322974/current-modalities-in-cancer-immunotherapy-immunomodulatory-antibodies-cars-and-vaccines
#9
REVIEW
Jason Lohmueller, Olivera J Finn
Successes of immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T cell therapy in curing patients with otherwise lethal cancers have validated immunotherapy as a treatment for cancer and have inspired excitement for its broader potential. Most promising is the ability of each approach to eliminate bulky and advanced-stage cancers and to achieve durable cures. Despite this success, to date only a subset of cancer patients and a limited number of cancer types respond to these therapies. A major goal now is to expand the types of cancer and number of patients who can be successfully treated...
March 16, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28321815/immune-therapy-for-sarcomas
#10
Peter M Anderson
Absolute lymphocyte count (ALC) recovery rapidly occurring at 14 days after start of chemotherapy for osteosarcoma and Ewing sarcoma is a good prognostic factor. Conversely, lymphopenia is associated with significantly decreased sarcoma survival. Clearly, the immune system can contribute towards better survival from sarcoma. This chapter will describe treatment and host factors that influence immune function and how effective local control and systemic interventions of sarcoma therapy can cause inflammation and/or immune suppression but are currently the standard of care...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28321813/harnessing-the-immune-system-against-leukemia-monoclonal-antibodies-and-checkpoint-strategies-for-aml
#11
Lucia Masarova, Hagop Kantarjian, Guillermo Garcia-Mannero, Farhad Ravandi, Padmanee Sharma, Naval Daver
Acute myeloid leukemia (AML) is the most common leukemia among adults and is associated with a poor prognosis, especially in patients with adverse prognostic factors, older age, or relapsed disease. The last decade has seen a surge in successful immune-based therapies in various solid tumors; however, the role of immune therapies in AML remains poorly defined. This chapter describes the rationale, clinical data, and toxicity profiles of immune-based therapeutic modalities in AML including naked and conjugated monoclonal antibodies, bispecific T-cell engager antibodies, chimeric antigen receptor (CAR)-T cells, and checkpoint blockade via blockade of PD1/PDL1 or CTLA4...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28321811/interleukin-2-old-and-new-approaches-to-enhance-immune-therapeutic-efficacy
#12
Pooja Dhupkar, Nancy Gordon
Interleukin-2 (IL-2) is a very well-known cytokine that has been studied for the past 35 years. It plays a major role in the growth and proliferation of many immune cells such NK and T cells. It is an important immunotherapy cytokine for the treatment of various diseases including cancer. Systemic delivery of IL-2 has shown clinical benefit in renal cell carcinoma and melanoma patients. However, its use has been limited by the numerous toxicities encountered with the systemic delivery. Intravenous IL-2 causes the well-known "capillary leak syndrome," or the leakage of fluid from the circulatory system to the interstitial space resulting in hypotension (low blood pressure), edema, and dyspnea that can lead to circulatory shock and eventually cardiopulmonary collapse and multiple organ failure...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28315560/cytokine-release-syndrome-inpatient-care-for-side-effects-of-car-t-cell-therapy%C3%A2
#13
Laura Smith, Kimberly Venella
BACKGROUND: Pediatric patients with relapsed and refractory acute lymphoblastic leukemia are more often being treated with chimeric antigen receptor (CAR) T-cell therapy. As with any new therapy, the management of this patient population has a unique set of challenges. The side effects of this therapy can range from mild to severe, with cytokine release syndrome being the most common reason for hospitalization.
. OBJECTIVES: This article presents common side effects, treatments, and challenges of caring for hospitalized patients who have received CAR T-cell therapy...
April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28315556/developing-infrastructure-managing-patients-with-cancer-undergoing-car-t-cell-therapy%C3%A2
#14
Elizabeth Halton, Diane Llerandi, Claudia Diamonte, Hilda Quintanilla, Donna Miale-Mayer
BACKGROUND: The introduction of chimeric antigen receptor (CAR) T-cell therapy has created challenges and opportunities for nurses. Clinical nurses must be educated on new treatment modalities to recognize toxicity symptoms and to support the therapy moving forward. 
. OBJECTIVES: This article will discuss nursing leadership and interventions to standardize care and ensure patient safety while receiving CAR T cells. 
. METHODS: Using evolving experience, an interprofessional team created standards of care and identified common toxicities and best practices for their management...
April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28315553/car-t-cell-therapy-pediatric-patients-with-relapsed-and-refractory-acute-lymphoblastic-leukemia%C3%A2
#15
Colleen Callahan, Diane Baniewicz, Beth Ely
BACKGROUND: Immunotherapy provides a promising treatment option for children and adolescents with refractory or relapsed acute lymphoblastic leukemia (ALL). 
. OBJECTIVES: This article presents a hospital's experience with providing chimeric antigen receptor (CAR) T-cell therapy, followed by a detailed discussion of the trajectory of treatment provided for pediatric patients and their families.
. METHODS: Clinical experience in delivering care to pediatric patients undergoing CAR T-cell therapy is described...
April 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28301076/clinical-development-of-anti-cd19-chimeric-antigen-receptor-t-cell-therapy-for-b-cell-non-hodgkin-lymphoma
#16
Shinichi Makita, Kiyoshi Yoshimura, Kensei Tobinai
B-cell non-Hodgkin lymphoma (B-NHL) is the most frequent hematological malignancy. Although refined chemotherapy regimens and several new therapeutics including rituximab, a chimeric anti-CD20 monoclonal antibody, have improved its prognosis in recent decades, there are still a substantial number of patients with chemorefractory B-NHL. Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is expected to be an effective adoptive cell treatment and has the potential to overcome the chemorefractoriness of B-cell leukemia and lymphoma...
March 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/28298232/elutriated-lymphocytes-for-manufacturing-chimeric-antigen-receptor-t-cells
#17
David F Stroncek, Daniel W Lee, Jiaqiang Ren, Marianna Sabatino, Steven Highfill, Hanh Khuu, Nirali N Shah, Rosandra N Kaplan, Terry J Fry, Crystal L Mackall
BACKGROUND: Clinical trials of Chimeric Antigen Receptor (CAR) T cells manufactured from autologous peripheral blood mononuclear cell (PBMC) concentrates for the treatment of hematologic malignancies have been promising, but CAR T cell yields have been variable. This variability is due in part to the contamination of the PBMC concentrates with monocytes and granulocytes. METHODS: Counter-flow elutriation allows for the closed system separation of lymphocytes from monocytes and granulocytes...
March 16, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28298134/car-t-cells-the-next-era-in-immuno-oncology
#18
Bruce A Feinberg, Jennifer Fillman, Justin Simoncini, Chadi Nabhan
No abstract text is available yet for this article.
February 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28298132/q-a-with-dr-jae-park-on-the-promise-of-car-t-cells-in-cancer-care
#19
Surabhi Dangi-Garimella
No abstract text is available yet for this article.
February 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28288656/incorporation-of-a-hinge-domain-improves-the-expansion-of-chimeric-antigen-receptor-t-cells
#20
Le Qin, Yunxin Lai, Ruocong Zhao, Xinru Wei, Jianyu Weng, Peilong Lai, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Yangqiu Li, Xuchao Zhang, Yilong Wu, Pentao Liu, Yao Yao, Duanqing Pei, Xin Du, Peng Li
BACKGROUND: Multiple iterations of chimeric antigen receptors (CARs) have been developed, mainly focusing on intracellular signaling modules. However, the effect of non-signaling extracellular modules on the expansion and therapeutic efficacy of CARs remains largely undefined. METHODS: We generated two versions of CAR vectors, with or without a hinge domain, targeting CD19, mesothelin, PSCA, MUC1, and HER2, respectively. Then, we systematically compared the effect of the hinge domains on the growth kinetics, cytokine production, and cytotoxicity of CAR T cells in vitro and in vivo...
March 13, 2017: Journal of Hematology & Oncology
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