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Naked mole rat

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https://www.readbyqxmd.com/read/29432174/naked-mole-rats-can-undergo-developmental-oncogene-induced-and-dna-damage-induced-cellular-senescence
#1
Yang Zhao, Alexander Tyshkovskiy, Daniel Muñoz-Espín, Xiao Tian, Manuel Serrano, Joao Pedro de Magalhaes, Eviatar Nevo, Vadim N Gladyshev, Andrei Seluanov, Vera Gorbunova
Cellular senescence is an important anticancer mechanism that restricts proliferation of damaged or premalignant cells. Cellular senescence also plays an important role in tissue remodeling during development. However, there is a trade-off associated with cellular senescence as senescent cells contribute to aging pathologies. The naked mole rat (NMR) ( Heterocephalus glaber ) is the longest-lived rodent that is resistant to a variety of age-related diseases. Remarkably, NMRs do not show aging phenotypes until very late stages of their lives...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29420271/forever-young-naked-mole-rats-may-know-the-secret
#2
Kai Kupferschmidt
No abstract text is available yet for this article.
February 2, 2018: Science
https://www.readbyqxmd.com/read/29364116/naked-mole-rat-mortality-rates-defy-gompertzian-laws-by-not-increasing-with-age
#3
J Graham Ruby, Megan Smith, Rochelle Buffenstein
The longest-lived rodent, the naked mole-rat (Heterocephalus glaber), has a reported maximum lifespan of >30 years and exhibits delayed and/or attenuated age-associated physiological declines. We questioned whether these mouse-sized, eusocial rodents conform to Gompertzian mortality laws by experiencing an exponentially increasing risk of death as they get older. We compiled and analyzed a large compendium of historical naked mole-rat lifespan data with >3000 data points. Kaplan-Meier analyses revealed a substantial portion of the population to have survived at 30 years of age...
January 24, 2018: ELife
https://www.readbyqxmd.com/read/29364114/age-is-just-a-number
#4
Hiram Beltrán-Sánchez, Caleb Finch
The naked mole rat defies the Gompertz law and shows no sign of increased mortality risk as it gets older.
January 24, 2018: ELife
https://www.readbyqxmd.com/read/29361591/naked-mole-rat-brain-mitochondria-electron-transport-system-flux-and-h-leak-are-reduced-during-acute-hypoxia
#5
Matthew E Pamenter, Gigi Y Lau, Jeffrey G Richards, William K Milsom
Mitochondrial respiration and ATP production are compromised by hypoxia. Naked mole rats (NMRs) are among the most hypoxia-tolerant mammals and reduce metabolic rate in hypoxic environments; however, little is known regarding mitochondrial function during in vivo hypoxia exposure in this species. To address this knowledge gap, we asked whether the function of NMR brain mitochondria exhibits metabolic plasticity during acute hypoxia. Respirometry was utilized to assess whole-animal oxygen consumption rates and high-resolution respirometry and was utilized to assess electron transport system (ETS) function in saponin-permeabilized NMR brain...
December 28, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29355712/divergent-behavioral-responses-to-acute-hypoxia-between-individuals-and-groups-of-naked-mole-rats
#6
Chelsea R Houlahan, Alexia M Kirby, Yvonne A Dzal, Garret D Fairman, Matthew E Pamenter
Most small rodents reduce energy demand in hypoxia via behavioral strategies. For example, animals may reduce their activity, and/or move to colder environments or alter huddling strategies to take advantage of anapyretical energy savings. Naked mole rats (NMRs) are among the most hypoxia tolerant mammals and are highly social; social interactions also have a significant impact on behaviour. Therefore, this species offers a fascinating model in which to study trade-offs between social interactions and energy conservation in hypoxia...
January 17, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29340215/genome-stability-maintenance-in-naked-mole-rat
#7
I O Petruseva, A N Evdokimov, O I Lavrik
The naked mole-rat (Heterocephalus glaber) is one of the most promising models used to study genome maintenance systems, including the effective repair of damage to DNA. The naked mole-rat is the longest lived rodent species, which is extraordinarily resistant to cancer and has a number of other unique phenotypic traits. For at least 80% of its lifespan, this animal shows no signs of aging or any increased likelihood of death and retains the ability to reproduce. The naked mole-rat draws the heightened attention of researchers who study the molecular basis of lengthy lifespan and cancer resistance...
October 2017: Acta Naturae
https://www.readbyqxmd.com/read/29332935/novel-treatment-strategies-for-chronic-kidney-disease-insights-from-the-animal-kingdom
#8
REVIEW
Peter Stenvinkel, Johanna Painer, Makoto Kuro-O, Miguel Lanaspa, Walter Arnold, Thomas Ruf, Paul G Shiels, Richard J Johnson
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these complications. Domestic and captive wild felids, for example, show susceptibility to chronic kidney disease (CKD), potentially linked to the high protein intake of these animals. By contrast, naked mole rats are a model of longevity and are protected from extreme environmental conditions through mechanisms that provide resistance to oxidative stress...
January 15, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29299120/hif-1%C3%AE-contributes-to-hypoxia-adaptation-of-the-naked-mole-rat
#9
Bang Xiao, Shiyong Wang, Guoshi Yang, Xiaoxi Sun, Shanmin Zhao, Lifang Lin, Jishuai Cheng, Wenjing Yang, Wei Cong, Wei Sun, Guanghan Kan, Shufang Cui
Background/Aims: Naked mole rats (NMRs) spend their lives in burrow systems containing very low levels of oxygen, indicating long-term hypoxic exposure, and suggesting that pathological changes caused by hypoxia are attenuated or absent in this hypoxia-tolerant species. The mechanisms underlying NMRs hypoxia tolerance remain poorly understood. In this study, we explored whether hypoxia inducible factor 1α (HIF-1α), and vascular endothelial growth factor A (VEGFA) play a role in NMRs adaption to hypoxia...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29281661/the-anti-tumorigenic-activity-of-a2m-a-lesson-from-the-naked-mole-rat
#10
Susanne Kurz, René Thieme, Ronny Amberg, Marco Groth, Heinz-Georg Jahnke, Philipp Pieroh, Lars-Christian Horn, Marlen Kolb, Klaus Huse, Matthias Platzer, Daniela Volke, Faramarz Dehghani, Anton Buzdin, Kathrin Engel, Andrea Robitzki, Ralf Hoffmann, Ines Gockel, Gerd Birkenmeier
Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat's cancer resistance. Notably, A2M is known to dramatically decrease with age in humans. We hypothesize that this might facilitate tumour development. Here we found that A2M modulates tumour cell adhesion, migration and growth by inhibition of tumour promoting signalling pathways, e...
2017: PloS One
https://www.readbyqxmd.com/read/29277975/perineuronal-nets-in-subcortical-auditory-nuclei-of-four-rodent-species-with-differing-hearing-ranges
#11
Nichole L Beebe, Brett R Schofield
Perineuronal nets (PNs) are aggregates of extracellular matrix molecules that surround some neurons in the brain. While PNs occur widely across many cortical areas, subcortical PNs are especially associated with motor and auditory systems. The auditory system has recently been suggested as an ideal model system for studying PNs and their functions. However, descriptions of PNs in subcortical auditory areas vary, and it is unclear whether the variation reflects species differences or differences in staining techniques...
December 26, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29277542/evolution-of-the-mc5r-gene-in-placental-mammals-with-evidence-for-its-inactivation-in-multiple-lineages-that-lack-sebaceous-glands
#12
Mark S Springer, John Gatesy
MC5R is one of five melanocortin receptor genes found in placental mammals. MC5R plays an important role in energy homeostasis and is also expressed in the terminal differentiation of sebaceous glands. Among placental mammals there are multiple lineages that either lack or have degenerative sebaceous glands including Cetacea (whales, dolphins, and porpoises), Hippopotamidae (hippopotamuses), Sirenia (manatees and dugongs), Proboscidea (elephants), Rhinocerotidae (rhinos), and Heterocephalus glaber (naked mole rat)...
December 19, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29237731/naked-mole-rat-acid-sensing-ion-channel-3-forms-nonfunctional-homomers-but-functional-heteromers
#13
Laura-Nadine Schuhmacher, Gerard Callejo, Shyam Srivats, Ewan St John Smith
Acid-sensing ion channels (ASICs) form both homotrimeric and heterotrimeric ion channels that are activated by extracellular protons and are involved in a wide range of physiological and pathophysiological processes, including pain and anxiety. ASIC proteins can form both homotrimeric and heterotrimeric ion channels. The ASIC3 subunit has been shown to be of particular importance in the peripheral nervous system with pharmacological and genetic manipulations demonstrating a role in pain. Naked mole-rats, despite having functional ASICs, are insensitive to acid as a noxious stimulus and show diminished avoidance of acidic fumes, ammonia and carbon dioxide...
December 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29228719/levels-of-leydig-cell-autophagy-regulate-the-fertility-of-male-naked-mole-rats
#14
Wenjing Yang, Li Li, Xiaofeng Huang, Guanghan Kan, Lifang Lin, Jishuai Cheng, Chen Xu, Wei Sun, Wei Cong, Shanmin Zhao, Shufang Cui
Fertility is abolished in nonbreeding males in colonies of natal naked mole-rats (NMRs). Although spermatogenesis occurs in both breeding and nonbreeding male NMRs, the mechanisms underlying the differences in fertility between breeders and nonbreeders remain unexplored. In this study, a significant decrease in autophagy was observed in Leydig cells of the testis from nonbreeding male NMRs. This alteration was visualised as a significant decrease in the levels of autophagy-related gene 7 (Atg7), Atg5, microtubule-associated protein 1A/B light chain 3 (LC3-II/I) and the number of autophagosomes and an increase in P62 levels using Western blotting analyses...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228582/comparative-study-of-macrophages-in-naked-mole-rats-and-icr-mice
#15
Jishuai Cheng, Zheng Yuan, Wenjing Yang, Chang Xu, Wei Cong, Lifang Lin, Shanmin Zhao, Wei Sun, Xiaosong Bai, Shufang Cui
The domestic and foreign scholars have studied naked mole rats more focused on the respect such as its long life, resistant to low oxygen, little spontaneous tumor, but the study of the immune system is little. In this study, we compared the anatomy and tissue morphology of NMR and ICR mouse spleens and found that the gross appearance of the NNMR spleen differed from ICR. There were more macrophages in NNMR spleens than in ICR spleens. Furthermore, we focused on the differences of macrophages. We compared their phagocytic capabilities and the data showed that NNMR macrophages are more phagocytic than ICR mouse macrophages...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29223874/the-hypoxia-tolerant-vertebrate-brain-arresting-synaptic-activity
#16
Leslie T Buck, Matthew E Pamenter
The ion channel arrest hypothesis has been the foundation of three decades of research into the underlying mechanisms of hypoxia/anoxia tolerance in several key species, including: painted turtles, goldfish, crucian carp, naked mole rats, and arctic and ground squirrels. The hypothesis originally stated that hypoxia/anoxia tolerant species ought to have fewer ion channels per area membrane and/or mechanisms to regulate the permeability of ions through channels. Today we can add to this and include mechanisms to remove channels from membranes and the expression of low conductance isoforms...
December 6, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29138211/transcriptome-sequencing-of-the-naked-mole-rat-heterocephalus-glaber-and-identification-of-hypoxia-tolerance-genes
#17
Bang Xiao, Li Li, Chang Xu, Shanmin Zhao, Lifang Lin, Jishuai Cheng, Wenjing Yang, Wei Cong, Guanghan Kan, Shufang Cui
The naked mole rat (NMR; Heterocephalus glaber) is a small rodent species found in regions of Kenya, Ethiopia and Somalia. It has a high tolerance for hypoxia and is thus, considered one of the most important natural models for studying hypoxia tolerance mechanisms. The various mechanisms underlying the NMR's hypoxia tolerance are beginning to be understood at different levels of organization, and next-generation sequencing methods promise to expand this understanding to the level of gene expression. In this study, we examined the sequence and transcript abundance data of the muscle transcriptome of NMRs exposed to hypoxia using the Illumina HiSeq 2500 system to clarify the possible genomic adaptive responses to the hypoxic underground surroundings...
November 14, 2017: Biology Open
https://www.readbyqxmd.com/read/29107597/naked-mole-rat-cells-have-a-stable-epigenome-that-resists-ipsc%C3%A2-reprogramming
#18
Li Tan, Zhonghe Ke, Gregory Tombline, Nicholas Macoretta, Kevin Hayes, Xiao Tian, Ruitu Lv, Julia Ablaeva, Michael Gilbert, Natarajan V Bhanu, Zuo-Fei Yuan, Benjamin A Garcia, Yujiang G Shi, Yang Shi, Andrei Seluanov, Vera Gorbunova
Naked mole rat (NMR) is a valuable model for aging and cancer research due to its exceptional longevity and cancer resistance. We observed that the reprogramming efficiency of NMR fibroblasts in response to OSKM was drastically lower than that of mouse fibroblasts. Expression of SV40 LargeT antigen (LT) dramatically improved reprogramming of NMR fibroblasts. Inactivation of Rb alone, but not p53, was sufficient to improve reprogramming efficiency, suggesting that NMR chromatin may be refractory to reprogramming...
November 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29107591/naked-mole-rat-induced-pluripotent-stem-cells-and-their-contribution-to-interspecific-chimera
#19
Sang-Goo Lee, Aleksei E Mikhalchenko, Sun Hee Yim, Alexei V Lobanov, Jin-Kyu Park, Kwang-Hwan Choi, Roderick T Bronson, Chang-Kyu Lee, Thomas J Park, Vadim N Gladyshev
Naked mole rats (NMRs) are exceptionally long-lived, cancer-resistant rodents. Identifying the defining characteristics of these traits may shed light on aging and cancer mechanisms. Here, we report the generation of induced pluripotent stem cells (iPSCs) from NMR fibroblasts and their contribution to mouse-NMR chimeric embryos. Efficient reprogramming could be observed under N2B27+2i conditions. The iPSCs displayed a characteristic morphology, expressed pluripotent markers, formed embryoid bodies, and showed typical differentiation patterns...
November 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29062810/a-trickster-in-disguise-hyaluronan-s-ambivalent-roles-in-the-matrix
#20
REVIEW
Lena Bohaumilitzky, Ann-Kathrin Huber, Eva Maria Stork, Simon Wengert, Franziska Woelfl, Heike Boehm
Hyaluronan (HA) is a simple but diverse glycosaminoglycan. It plays a major role in aging, cellular senescence, cancer, and tissue homeostasis. In which way HA affects the surrounding tissues greatly depends on the molecular weight of HA. Whereas high molecular weight HA is associated with homeostasis and protective effects, HA fragments tend to be linked to the pathologic state. Furthermore, the interaction of HA with its binding partners, the hyaladherins, such as CD44, is essential for sustaining tissue integrity and is likewise related to cancer...
2017: Frontiers in Oncology
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