keyword
MENU ▼
Read by QxMD icon Read
search

Naked mole rat

keyword
https://www.readbyqxmd.com/read/28202600/neoteny-prolongation-of-youth-from-naked-mole-rats-to-naked-apes-humans
#1
REVIEW
Vladimir P Skulachev, Susanne Holtze, Mikhail Y Vyssokikh, Lora E Bakeeva, Maxim V Skulachev, Alexander V Markov, Thomas B Hildebrandt, Viktor A Sadovnichii
It has been suggested that highly social mammals, such as naked mole rats and humans, are long-lived due to neoteny (the prolongation of youth). In both species, aging cannot operate as a mechanism facilitating natural selection because the pressure of this selection is strongly reduced due to 1) a specific social structure where only the "queen" and her "husband(s)" are involved in reproduction (naked mole rats) or 2) substituting fast technological progress for slow biological evolution (humans). Lists of numerous traits of youth that do not disappear with age in naked mole rats and humans are presented and discussed...
April 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28096421/rfamide-related-peptide-3-rfrp-3-suppresses-sexual-maturation-in-a-eusocial-mammal
#2
Diana E Peragine, Martha Pokarowski, Lucia Mendoza-Viveros, Ashlyn Swift-Gallant, Hai-Ying M Cheng, George E Bentley, Melissa M Holmes
Neuroendocrine mechanisms underlying social inhibition of puberty are not well understood. Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in neuroendocrine control of reproductive development. Naked mole rats (NMRs) live in sizable colonies where breeding is monopolized by two to four dominant animals, and no other members exhibit signs of puberty throughout their lives unless they are removed from the colony...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27997359/naked-mole-rats-maintain-healthy-skeletal-muscle-and-complex-iv-mitochondrial-enzyme-function-into-old-age
#3
Elizabeth A Stoll, Nevena Karapavlovic, Hannah Rosa, Michael Woodmass, Karolina Rygiel, Kathryn White, Douglass M Turnbull, Chris G Faulkes
The naked mole-rat (NMR) Heterocephalus glaber is an exceptionally long-lived rodent, living up to 32 years in captivity. This extended lifespan is accompanied by a phenotype of negligible senescence, a phenomenon of very slow changes in the expected physiological characteristics with age. One of the many consequences of normal aging in mammals is the devastating and progressive loss of skeletal muscle, termed sarcopenia, caused in part by respiratory enzyme dysfunction within the mitochondria of skeletal muscle fibers...
December 19, 2016: Aging
https://www.readbyqxmd.com/read/27974493/variation-in-growth-of-damaraland-mole-rats-is-explained-by-competition-rather-than-by-functional-specialization-for-different-tasks
#4
Markus Zöttl, Jack Thorley, David Gaynor, Nigel C Bennett, Tim Clutton-Brock
In some eusocial insect societies, adaptation to the division of labour results in multimodal size variation among workers. It has been suggested that variation in size and growth among non-breeders in naked and Damaraland mole-rats may similarly reflect functional divergence associated with different cooperative tasks. However, it is unclear whether individual growth rates are multimodally distributed (as would be expected if variation in growth is associated with specialization for different tasks) or whether variation in growth is unimodally distributed, and is related to differences in the social and physical environment (as would be predicted if there are individual differences in growth but no discrete differences in developmental pathways)...
December 2016: Biology Letters
https://www.readbyqxmd.com/read/27964758/expression-of-acid-sensing-ion-channels-and-selection-of-reference-genes-in-mouse-and-naked-mole-rat
#5
Laura-Nadine Schuhmacher, Ewan St John Smith
Acid-sensing ion channels (ASICs) are a family of ion channels comprised of six subunits encoded by four genes and they are expressed throughout the peripheral and central nervous systems. ASICs have been implicated in a wide range of physiological and pathophysiological processes: pain, breathing, synaptic plasticity and excitotoxicity. Unlike mice and humans, naked mole-rats do not perceive acid as a noxious stimulus, even though their sensory neurons express functional ASICs, likely an adaptation to living in a hypercapnic subterranean environment...
December 13, 2016: Molecular Brain
https://www.readbyqxmd.com/read/27936183/molecular-evolution-of-pten-pseudogenes-in-mammals
#6
Jingsi Tang, Ruihong Ning, Bo Zeng, Ying Li
Phosphatase and tensin homolog (PTEN) is a tumor-suppressor gene. PTEN pseudogene (PTENp) acts as an endogenous RNA, which regulates its parental gene by competitively binding to the 3' UTR of PTEN gene in the human. Despite the importance of this pseudogene, little is known about the molecular evolution of PTENp in mammals. In this study, we identified 37 pseudogenes from 65 mammalian genomes. Among them, 32 were from rodents or primates. Phylogenetic analyse showed a complex evolutionary history of this gene family...
2016: PloS One
https://www.readbyqxmd.com/read/27926945/ear-structures-of-the-naked-mole-rat-heterocephalus-glaber-and-its-relatives-rodentia-bathyergidae
#7
Matthew J Mason, Hannah L Cornwall, Ewan St J Smith
Although increasingly popular as a laboratory species, very little is known about the peripheral auditory system of the naked mole-rat, Heterocephalus glaber. In this study, middle and inner ears of naked mole-rats of a range of ages were examined using micro-computed tomography and dissection. The ears of five other bathyergid species (Bathyergus suillus, Cryptomys hottentotus, Fukomys micklemi, Georychus capensis and Heliophobius argenteocinereus) were examined for comparative purposes. The middle ears of bathyergids show features commonly found in other members of the Ctenohystrica rodent clade, including a fused malleus and incus, a synovial stapedio-vestibular articulation and the loss of the stapedius muscle...
2016: PloS One
https://www.readbyqxmd.com/read/27877105/extended-postnatal-brain-development-in-the-longest-lived-rodent-prolonged-maintenance-of-neotenous-traits-in-the-naked-mole-rat-brain
#8
Miranda E Orr, Valentina R Garbarino, Angelica Salinas, Rochelle Buffenstein
The naked mole-rat (NMR) is the longest-lived rodent with a maximum lifespan >31 years. Intriguingly, fully-grown naked mole-rats (NMRs) exhibit many traits typical of neonatal rodents. However, little is known about NMR growth and maturation, and we question whether sustained neotenous features when compared to mice, reflect an extended developmental period, commensurate with their exceptionally long life. We tracked development from birth to 3 years of age in the slowest maturing organ, the brain, by measuring mass, neural stem cell proliferation, axonal, and dendritic maturation, synaptogenesis and myelination...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27863375/h2o2-treatment-or-serum-deprivation-induces-autophagy-and-apoptosis-in-naked-mole-rat-skin-fibroblasts-by-inhibiting-the-pi3k-akt-signaling-pathway
#9
Shanmin Zhao, Li Li, Shiyong Wang, Chenlin Yu, Bang Xiao, Lifang Lin, Wei Cong, Jishuai Cheng, Wenjing Yang, Wei Sun, Shufang Cui
Naked mole-rats (NMR; Heterocephalus glaber) display extreme longevity and resistance to cancer. Here, we examined whether autophagy contributes to the longevity of NMRs by assessing the effects of the PI3K/Akt pathway inhibitor LY294002 and the autophagy inhibitor chloroquine (CQ) on autophagy and apoptosis in NMR skin fibroblasts. Serum starvation, H2O2 treatment, and LY294002 treatment all increased the LC3-II/LC3-I ratio and numbers of double-membraned autophagosomes and autophagic vacuoles, and decreased levels of p70S6K, p-AktSer473, and p-AktThr308...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27833660/insights-into-long-noncoding-rnas-of-naked-mole-rat-heterocephalus-glaber-and-their-potential-association-with-cancer-resistance
#10
Jian-Jun Jiang, Le-Hua Cheng, Huan Wu, Yong-Han He, Qing-Peng Kong
BACKGROUND: Long noncoding RNAs (lncRNAs) are a class of ubiquitous noncoding RNAs and have been found to act as tumor suppressors or oncogenes, which dramatically altered our understanding of cancer. Naked mole rat (NMR, Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent; however, whether lncRNAs play roles in cancer resistance in this seductive species remains unknown. RESULTS: In this study, we developed a pipeline and identified a total of 4422 lncRNAs across the NMR genome based on 12 published transcriptomes...
2016: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/27732851/hypofunctional-trka-accounts-for-the-absence-of-pain-sensitization-in-the-african-naked-mole-rat
#11
Damir Omerbašić, Ewan St J Smith, Mirko Moroni, Johanna Homfeld, Ole Eigenbrod, Nigel C Bennett, Jane Reznick, Chris G Faulkes, Matthias Selbach, Gary R Lewin
The naked mole-rat is a subterranean rodent lacking several pain behaviors found in humans, rats, and mice. For example, nerve growth factor (NGF), an important mediator of pain sensitization, fails to produce thermal hyperalgesia in naked mole-rats. The sensitization of capsaicin-sensitive TRPV1 ion channels is necessary for NGF-induced hyperalgesia, but naked mole-rats have fully functional TRPV1 channels. We show that exposing isolated naked mole-rat nociceptors to NGF does not sensitize TRPV1. However, the naked mole-rat NGF receptor TrkA displays a reduced ability to engage signal transduction pathways that sensitize TRPV1...
October 11, 2016: Cell Reports
https://www.readbyqxmd.com/read/27588902/differences-in-cooperative-behavior-among-damaraland-mole-rats-are-consequences-of-an-age-related-polyethism
#12
Markus Zöttl, Philippe Vullioud, Rute Mendonça, Miquel Torrents Ticó, David Gaynor, Adam Mitchell, Tim Clutton-Brock
In many cooperative breeders, the contributions of helpers to cooperative activities change with age, resulting in age-related polyethisms. In contrast, some studies of social mole rats (including naked mole rats, Heterocephalus glaber, and Damaraland mole rats, Fukomys damarensis) suggest that individual differences in cooperative behavior are the result of divergent developmental pathways, leading to discrete and permanent functional categories of helpers that resemble the caste systems found in eusocial insects...
September 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27453637/distributions-of-oxytocin-and-vasopressin-1a-receptors-in-the-taiwan-vole-and-their-role-in-social-monogamy
#13
A R Chappell, S M Freeman, Y K Lin, J L LaPrairie, K Inoue, L J Young, L D Hayes
Social monogamy is a mating strategy rarely employed by mammalian species. Laboratory studies in socially monogamous prairie voles (Microtus ochrogaster) demonstrate that oxytocin and vasopressin act within the mesolimbic dopamine pathway to facilitate pair-bond formation. Species differences in oxytocin receptor (OTR) and vasopressin 1a receptor (V1aR) distribution in this pathway are associated with species differences in mating strategy. Here we characterize the neuroanatomical distribution of OTR and V1aR binding sites in naturally occurring populations of Taiwan voles (M...
June 2016: Journal of Zoology: Proceedings of the Zoological Society of London
https://www.readbyqxmd.com/read/27439089/digging-into-the-genome-of-naked-mole-rats
#14
Gregory D Larsen
No abstract text is available yet for this article.
July 20, 2016: Lab Animal
https://www.readbyqxmd.com/read/27364349/unraveling-the-message-insights-into-comparative-genomics-of-the-naked-mole-rat
#15
REVIEW
Kaitlyn N Lewis, Ilya Soifer, Eugene Melamud, Margaret Roy, R Scott McIsaac, Matthew Hibbs, Rochelle Buffenstein
Animals have evolved to survive, and even thrive, in different environments. Genetic adaptations may have indirectly created phenotypes that also resulted in a longer lifespan. One example of this phenomenon is the preternaturally long-lived naked mole-rat. This strictly subterranean rodent tolerates hypoxia, hypercapnia, and soil-based toxins. Naked mole-rats also exhibit pronounced resistance to cancer and an attenuated decline of many physiological characteristics that often decline as mammals age. Elucidating mechanisms that give rise to their unique phenotypes will lead to better understanding of subterranean ecophysiology and biology of aging...
August 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/27350178/retinal-ganglion-cell-survival-and-axon-regeneration-after-optic-nerve-injury-in-naked-mole-rats
#16
Kevin K Park, Xueting Luo, Skyler J Mooney, Benjamin J Yungher, Stephane Belin, Chen Wang, Melissa M Holmes, Zhigang He
In the adult mammalian central nervous system (CNS), axonal damage often triggers neuronal cell death and glial activation, with very limited spontaneous axon regeneration. In this study, we performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maximum life span exceeding 30 years, and found that injury responses in this species are quite distinct from those in other mammalian species. In contrast to what is seen in other mammals, the majority of injured retinal ganglion cells (RGCs) survive with relatively high spontaneous axon regeneration...
February 1, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27239229/analysis-of-cultivable-microbiota-and-diet-intake-pattern-of-the-long-lived-naked-mole-rat
#17
Tewodros Debebe, Susanne Holtze, Michaela Morhart, Thomas Bernd Hildebrandt, Steffen Rodewald, Klaus Huse, Matthias Platzer, Dereje Wyohannes, Salomon Yirga, Alemayehu Lemma, Rene Thieme, Brigitte König, Gerd Birkenmeier
BACKGROUND: A variety of microbial communities exist throughout the human and animal body. Genetics, environmental factors and long-term dietary habit contribute to shaping the composition of the gut microbiota. For this reason the study of the gut microbiota of a mammal exhibiting an extraordinary life span is of great importance. The naked mole-rat (Heterocephalus glaber) is a eusocial mammal known for its longevity and cancer resistance. METHODS: Here we analyzed its gut microbiota by cultivating the bacteria under aerobic and anaerobic conditions and identifying their species by mass spectrometry...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27232489/-the-anti-tumor-mechanisms-in-long-lived-rodents
#18
Yanjiao Dong, Yue Pang, Qingwei Li
Rodents, including the nude mice with congenital aplasia of the thymus, cancer-resistant naked mole rat (Heterocephalus glaber) and blind mole rat (Spalax galili), are important model organisms that are widely used in biomedical research. The aging process is closely related to cancer incidence in mammals and the aging degree is positively correlated with the risk of cancer. Since rodents account for 40% of mammals, study of the unique antitumor mechanism in long-lived rodents is very important. Replicative senescence is anti-tumor mechanism that prevalently exist in rodents, however, unique anti-tumor mechanisms have been found in naked mole-rats and blind mole-rats...
May 2016: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/27163160/sensitivity-of-primary-fibroblasts-in-culture-to-atmospheric-oxygen-does-not-correlate-with-species-lifespan
#19
Alison Patrick, Michael Seluanov, Chaewon Hwang, Jonathan Tam, Tanya Khan, Ari Morgenstern, Lauren Wiener, Juan M Vazquez, Hiba Zafar, Robert Wen, Malika Muratkalyeva, Katherine Doerig, Maria Zagorulya, Lauren Cole, Sophia Catalano, Aliny Ab Lobo Ladd, A Augusto Coppi, Yüksel Coşkun, Xiao Tian, Julia Ablaeva, Eviatar Nevo, Vadim N Gladyshev, Zhengdong D Zhang, Jan Vijg, Andrei Seluanov, Vera Gorbunova
Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the striking difference in oxygen sensitivity between mouse and human cells explains their different rates of aging. To test if this hypothesis is broadly applicable, we cultured cells from 16 rodent species with diverse lifespans in 3% and 21% oxygen and compared their growth rates...
May 2016: Aging
https://www.readbyqxmd.com/read/27161380/tumour-resistance-in-induced-pluripotent-stem-cells-derived-from-naked-mole-rats
#20
Shingo Miyawaki, Yoshimi Kawamura, Yuki Oiwa, Atsushi Shimizu, Tsuyoshi Hachiya, Hidemasa Bono, Ikuko Koya, Yohei Okada, Tokuhiro Kimura, Yoshihiro Tsuchiya, Sadafumi Suzuki, Nobuyuki Onishi, Naoko Kuzumaki, Yumi Matsuzaki, Minoru Narita, Eiji Ikeda, Kazuo Okanoya, Ken-Ichiro Seino, Hideyuki Saya, Hideyuki Okano, Kyoko Miura
The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs) and find that NMR-iPSCs do not exhibit teratoma-forming tumorigenicity due to the species-specific activation of tumour-suppressor alternative reading frame (ARF) and a disruption mutation of the oncogene ES cell-expressed Ras (ERAS)...
2016: Nature Communications
keyword
keyword
46720
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"