Shamir Montazid, Sheila Bandyopadhyay, Daniel W Hart, Nan Gao, Brian Johnson, Sri G Thrumurthy, Dustin J Penn, Bettina Wernisch, Mukesh Bansal, Philipp M Altrock, Fabian Rost, Patrycja Gazinska, Piotr Ziolkowski, Bu'Hussain Hayee, Yue Liu, Jiangmeng Han, Annamaria Tessitore, Jana Koth, Walter F Bodmer, James E East, Nigel C Bennett, Ian Tomlinson, Shazia Irshad
The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity and tissue function with increasing lifespan. Using cumulative BrdU labelling and a quantitative imaging approach to track intestinal ASCs (Lgr5+ ) in their native in vivo state, we find an expanded pool of Lgr5+ cells in NMRs, and these cells specifically at the crypt base (Lgr5+CBC ) exhibit slower division rates compared to those in short-lived mice but have a similar turnover as human LGR5+CBC cells...
December 20, 2023: Nature Communications