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Naked mole rat

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https://www.readbyqxmd.com/read/28939386/investigation-into-the-role-of-an-extracellular-loop-in-mediating-proton-evoked-inhibition-of-voltage-gated-sodium-channels
#1
Elisa Harms, Carsten Stoetzer, Thomas Stueber, Andrias O O'Reilly, Andreas Leffler
Proton-evoked activation of sensory neurons is counteracted by inhibition of voltage-gated Na(+) channels, and the low acid-sensitivity of sensory neuron of the African naked mole-rat (ANMr) was reported to be due to a strong proton-evoked block of ANMrNav1.7. Here we aimed to reevaluate the role of the suggested negatively-charged motif in the ANMrNav1.7 domain IV P-loop for inhibition by protons. Patch clamp recordings were performed on the recombinant α-subunits Nav1.2-1.8. The insertion of the negatively charged motif (EKE) of ANMrNav1...
September 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28905723/breeding-and-rearing-naked-mole-rats-heterocephalus-glaber-under-laboratory-conditions
#2
Chenlin Yu, Shiyong Wang, Guoshi Yang, Shanmin Zhao, Lifang Lin, Wenjing Yang, Qiu Tang, Wei Sun, Shufang Cui
The unique biologic characteristics of naked mole-rats (NMR, Heterocephalus glaber) include longevity, cancer resistance, hypoxia tolerance, and pain insensitivity, making NMR an attractive model for biomedical research on aging, cancer, and neurobiology. However, breeding and rearing NMR in captivity is challenging. Here, we report a method for breeding NMR by using a closed-colony mating system. We selected sexually mature male and female NMR from different natal colonies and mated them 1:1. The 5 original colonies had an annual parity of 3...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28899002/the-unexpected-intelligence-what-is-the-naked-mole-rat-s-secret-to-surviving-oxygen-deprivation
#3
Senka Ljubojevic-Holzer
No abstract text is available yet for this article.
August 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28852094/unraveling-the-gut-microbiome-of-the-long-lived-naked-mole-rat
#4
Tewodros Debebe, Elena Biagi, Matteo Soverini, Susanne Holtze, Thomas Bernd Hildebrandt, Claudia Birkemeyer, Dereje Wyohannis, Alemayehu Lemma, Patrizia Brigidi, Vulk Savkovic, Brigitte König, Marco Candela, Gerd Birkenmeier
The naked mole-rat (Heterocephalus glaber) is a subterranean mouse-sized African mammal that shows astonishingly few age-related degenerative changes and seems to not be affected by cancer. These features make this wild rodent an excellent model to study the biology of healthy aging and longevity. Here we characterize for the first time the intestinal microbial ecosystem of the naked mole-rat in comparison to humans and other mammals, highlighting peculiarities related to the specific living environment, such as the enrichment in bacteria able to utilize soil sulfate as a terminal electron acceptor to sustain an anaerobic oxidative metabolism...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800931/molecular-signatures-of-longevity-insights-from-cross-species-comparative-studies
#5
REVIEW
Siming Ma, Vadim N Gladyshev
Much of the current research on longevity focuses on the aging process within a single species. Several molecular players (e.g. IGF1 and MTOR), pharmacological compounds (e.g. rapamycin and metformin), and dietary approaches (e.g. calorie restriction and methionine restriction) have been shown to be important in regulating and modestly extending lifespan in model organisms. On the other hand, natural lifespan varies much more significantly across species. Within mammals alone, maximum lifespan differs more than 100 fold, but the underlying regulatory mechanisms remain poorly understood...
October 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28780992/functional-morphology-of-the-olfactory-mucosa-and-olfactory-bulb-in-fossorial-rodents-the-east-african-root-rat-tachyoryctes-splendens-and-the-naked-mole-rat-heterocephalus-glaber
#6
P N Onyono, B M Kavoi, S G Kiama, A N Makanya
Optimal functioning of the olfactory system is critical for survival of fossorial rodents in their subterranean lifestyle. This study examines the structure of the olfactory mucosa and olfactory bulb of two fossorial rodents exhibiting distinct social behaviors, the East African root rat and the naked mole rat. The social naked mole rat displayed simpler ethmoturbinates consisting of dorsomedial and broad discoid/flaplike parts that projected rostrally from the ethmoid bone. In the solitary root rat however, the ethmoturbinates were highly complex and exhibited elaborate branching which greatly increased the olfactory surface area...
July 28, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28780592/the-naked-mole-rat-exhibits-an-unusual-cardiac-myofilament-protein-profile-providing-new-insights-into-heart-function-of-this-naturally-subterranean-rodent
#7
Kelly M Grimes, David Y Barefield, Mohit Kumar, James W McNamara, Susan T Weintraub, Pieter P de Tombe, Sakthivel Sadayappan, Rochelle Buffenstein
The long-lived, hypoxic-tolerant naked mole-rat well-maintains cardiac function over its three-decade-long lifespan and exhibits many cardiac features atypical of similar-sized laboratory rodents. For example, they exhibit low heart rates and resting cardiac contractility, yet have a large cardiac reserve. These traits are considered ecophysiological adaptations to their dank subterranean atmosphere of low oxygen and high carbon dioxide levels and may also contribute to negligible declines in cardiac function during aging...
August 5, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28775241/comparative-study-of-macrophages-in-naked-mole-rats-and-icr-mice
#8
Jishuai Cheng, Zheng Yuan, Wenjing Yang, Chang Xu, Wei Cong, Lifang Lin, Shanmin Zhao, Wei Sun, Xiaosong Bai, Shufang Cui
The domestic and foreign scholars have studied naked mole rats more focused on the respect such as its long life, resistant to low oxygen, little spontaneous tumor, but the study of the immune system is little. In this study, we compared the anatomy and tissue morphology of NMR and ICR mouse spleens and found that the gross appearance of the NNMR spleen differed from ICR. There were more macrophages in NNMR spleens than in ICR spleens. Furthermore, we focused on the differences of macrophages. We compared their phagocytic capabilities and the data showed that NNMR macrophages are more phagocytic than ICR mouse macrophages...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28698112/slow-aging-in-mammals-lessons-from-african-mole-rats-and-bats
#9
REVIEW
Philip Dammann
Traditionally, the main mammalian models used in aging research have been mice and rats, i.e. short-lived species that obviously lack effective maintenance mechanisms to keep their soma in a functional state for prolonged periods of time. It is doubtful that life-extending mechanisms identified only in such short-lived species adequately reflect the diversity of longevity pathways that have naturally evolved in mammals, or that they have much relevance for long-lived species such as humans. Therefore, some complementary, long-lived mammalian models have been introduced to aging research in the past 15-20 years, particularly naked mole-rats (and to a lesser extent also other mole-rats) and bats...
October 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28672778/correction-h2o2-treatment-or-serum-deprivation-induces-autophagy-and-apoptosis-in-naked-mole-rat-skin-fibroblasts-by-inhibiting-the-pi3k-akt-signaling-pathway
#10
Shanmin Zhao, Li Li, Shiyong Wang, Chenlin Yu, Bang Xiao, Lifang Lin, Wei Cong, Jishuai Cheng, Wenjing Yang, Wei Sun, Shufang Cui
No abstract text is available yet for this article.
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28472634/learning-of-nature-the-curious-case-of-the-naked-mole-rat
#11
REVIEW
Francisco Alejandro Lagunas-Rangel, Venice Chávez-Valencia
Naked mole rats (NMRs) are the longest-living rodents known, living up to approximately 30 years and showing sustained good health. Nowadays, NMRs are considered excellent models for aging and, additionally, for cancer research, due to the evidence of a remarkable cancer resistance demonstrated through thousands of necropsies performed with very few cases that describe this pathology, which is believed to be a disease that unavoidably accompanies aging. Since some years ago, several studies have tried to explain the possible mechanisms underlying longevity and cancer resistance in NMRs through different perspectives and directions, creating new knowledge that subsequently could be used for cancer prevention and delaying aging in humans...
May 1, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28442628/papers-of-note-in-science356-6335
#12
Annalisa M VanHook
This week's articles highlight a peptide that controls myoblast fusion; a metabolic adaptation that enables naked mole-rats to resist the detrimental effects of anoxia; a transcription factor that coordinates signaling in the mammary epithelial stem cell niche; and transgenerational epigenetic inheritance of the response to an environmental stimulus.
April 25, 2017: Science Signaling
https://www.readbyqxmd.com/read/28428423/fructose-driven-glycolysis-supports-anoxia-resistance-in-the-naked-mole-rat
#13
Thomas J Park, Jane Reznick, Bethany L Peterson, Gregory Blass, Damir Omerbašić, Nigel C Bennett, P Henning J L Kuich, Christin Zasada, Brigitte M Browe, Wiebke Hamann, Daniel T Applegate, Michael H Radke, Tetiana Kosten, Heike Lutermann, Victoria Gavaghan, Ole Eigenbrod, Valérie Bégay, Vince G Amoroso, Vidya Govind, Richard D Minshall, Ewan St J Smith, John Larson, Michael Gotthardt, Stefan Kempa, Gary R Lewin
The African naked mole-rat's (Heterocephalus glaber) social and subterranean lifestyle generates a hypoxic niche. Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and survive 18 minutes of total oxygen deprivation (anoxia) without apparent injury. During anoxia, the naked mole-rat switches to anaerobic metabolism fueled by fructose, which is actively accumulated and metabolized to lactate in the brain. Global expression of the GLUT5 fructose transporter and high levels of ketohexokinase were identified as molecular signatures of fructose metabolism...
April 21, 2017: Science
https://www.readbyqxmd.com/read/28259120/study-of-age-dependent-structural-and-functional-changes-of-mitochondria-in-skeletal-muscles-and-heart-of-naked-mole-rats-heterocephalus-glaber
#14
S Holtze, C M Eldarov, V B Vays, I M Vangeli, M Yu Vysokikh, L E Bakeeva, V P Skulachev, T B Hildebrandt
Morphometric analysis of mitochondria in skeletal muscles and heart of 6- and 60-month-old naked mole rats (Heterocephalus glaber) revealed a significant age-dependent increase in the total area of mitochondrial cross-sections in studied muscle fibers. For 6- and 60-month-old animals, these values were 4.8 ± 0.4 and 12.7 ± 1.8%, respectively. This effect is mainly based on an increase in the number of mitochondria. In 6-month-old naked mole rats, there were 0.23 ± 0.02 mitochondrial cross-sections per µm(2) of muscle fiber, while in 60-month-old animals this value was 0...
December 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28244876/adaptive-sequence-convergence-of-the-tumor-suppressor-adamts9-between-small-bodied-mammals-displaying-exceptional-longevity
#15
Matthew J Lambert, Christine V Portfors
Maximum lifespan varies by two orders of magnitude across mammals. How such divergent lifespans have evolved remains an open question, with ramifications that may potentially lead to therapies for age-related diseases in humans. Several species of microbats as well as the naked mole-rat live much longer than expected given their small sizes, show reduced susceptibility to neoplasia, and largely remain healthy and reproductively capable throughout the majority of their extended lifespans. The convergent evolution of extreme longevity in these two groups allows for the opportunity to identify potentially important aging related genes that have undergone adaptive sequence convergence in these long-lived, yet small-bodied species...
February 26, 2017: Aging
https://www.readbyqxmd.com/read/28202600/neoteny-prolongation-of-youth-from-naked-mole-rats-to-naked-apes-humans
#16
REVIEW
Vladimir P Skulachev, Susanne Holtze, Mikhail Y Vyssokikh, Lora E Bakeeva, Maxim V Skulachev, Alexander V Markov, Thomas B Hildebrandt, Viktor A Sadovnichii
It has been suggested that highly social mammals, such as naked mole rats and humans, are long-lived due to neoteny (the prolongation of youth). In both species, aging cannot operate as a mechanism facilitating natural selection because the pressure of this selection is strongly reduced due to 1) a specific social structure where only the "queen" and her "husband(s)" are involved in reproduction (naked mole rats) or 2) substituting fast technological progress for slow biological evolution (humans). Lists of numerous traits of youth that do not disappear with age in naked mole rats and humans are presented and discussed...
April 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28096421/rfamide-related-peptide-3-rfrp-3-suppresses-sexual-maturation-in-a-eusocial-mammal
#17
Diana E Peragine, Martha Pokarowski, Lucia Mendoza-Viveros, Ashlyn Swift-Gallant, Hai-Ying M Cheng, George E Bentley, Melissa M Holmes
Neuroendocrine mechanisms underlying social inhibition of puberty are not well understood. Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in neuroendocrine control of reproductive development. Naked mole rats (NMRs) live in sizable colonies where breeding is monopolized by two to four dominant animals, and no other members exhibit signs of puberty throughout their lives unless they are removed from the colony...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27997359/naked-mole-rats-maintain-healthy-skeletal-muscle-and-complex-iv-mitochondrial-enzyme-function-into-old-age
#18
Elizabeth A Stoll, Nevena Karapavlovic, Hannah Rosa, Michael Woodmass, Karolina Rygiel, Kathryn White, Douglass M Turnbull, Chris G Faulkes
The naked mole-rat (NMR) Heterocephalus glaber is an exceptionally long-lived rodent, living up to 32 years in captivity. This extended lifespan is accompanied by a phenotype of negligible senescence, a phenomenon of very slow changes in the expected physiological characteristics with age. One of the many consequences of normal aging in mammals is the devastating and progressive loss of skeletal muscle, termed sarcopenia, caused in part by respiratory enzyme dysfunction within the mitochondria of skeletal muscle fibers...
December 19, 2016: Aging
https://www.readbyqxmd.com/read/27974493/variation-in-growth-of-damaraland-mole-rats-is-explained-by-competition-rather-than-by-functional-specialization-for-different-tasks
#19
Markus Zöttl, Jack Thorley, David Gaynor, Nigel C Bennett, Tim Clutton-Brock
In some eusocial insect societies, adaptation to the division of labour results in multimodal size variation among workers. It has been suggested that variation in size and growth among non-breeders in naked and Damaraland mole-rats may similarly reflect functional divergence associated with different cooperative tasks. However, it is unclear whether individual growth rates are multimodally distributed (as would be expected if variation in growth is associated with specialization for different tasks) or whether variation in growth is unimodally distributed, and is related to differences in the social and physical environment (as would be predicted if there are individual differences in growth but no discrete differences in developmental pathways)...
December 2016: Biology Letters
https://www.readbyqxmd.com/read/27964758/expression-of-acid-sensing-ion-channels-and-selection-of-reference-genes-in-mouse-and-naked-mole-rat
#20
Laura-Nadine Schuhmacher, Ewan St John Smith
Acid-sensing ion channels (ASICs) are a family of ion channels comprised of six subunits encoded by four genes and they are expressed throughout the peripheral and central nervous systems. ASICs have been implicated in a wide range of physiological and pathophysiological processes: pain, breathing, synaptic plasticity and excitotoxicity. Unlike mice and humans, naked mole-rats do not perceive acid as a noxious stimulus, even though their sensory neurons express functional ASICs, likely an adaptation to living in a hypercapnic subterranean environment...
December 13, 2016: Molecular Brain
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