J M Pinazo-Bandera, H Niu, Alvarez-Alvarez, Medina-Caliz, E Del Campo-Herrera, A Ortega-Alonso, M Robles-Díaz, N Hernández, R Paraná, Nunes, M Girala, F Bessone, M I Lucena, R J Andrade, M García Cortés
INTRODUCTION: Data on positive rechallenge in idiosyncratic drug-induced liver injury (DILI) are scarce. We aim to analyse the clinical presentation, outcome and drugs associated with positive rechallenge in two DILI registries. METHODS: Cases from the Spanish and Latin American DILI registries were included. Demographics, clinical characteristics and outcome of cases with positive rechallenge according to CIOMS/RUCAM and current definitions were analysed. RESULTS: Of 1,418 patients with idiosyncratic DILI, 58 cases had positive rechallenge (4...
April 15, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society