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conductive hearing loss

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https://www.readbyqxmd.com/read/29331482/genetic-basis-of-hearing-loss-in-spanish-hispanic-and-latino-populations
#1
REVIEW
Rahul Mittal, Amit P Patel, Desiree Nguyen, Debbie R Pan, Vasanti M Jhaveri, Jason R Rudman, Arjuna Dharmaraja, Denise Yan, Yong Feng, Prem Chapagain, David J Lee, Susan H Blanton, Xue Zhong Liu
Hearing loss (HL) is the most common neurosensory disorder affecting humans. The screening, prevention and treatment of HL require a better understanding of the underlying molecular mechanisms. Genetic predisposition is one of the most common factors that leads to HL. Most HL studies include few Spanish, Hispanic and Latino participants, leaving a critical gap in our understanding about the prevalence, impact, unmet health care needs, and genetic factors associated with hearing impairment among Spanish, Hispanic and Latino populations...
January 10, 2018: Gene
https://www.readbyqxmd.com/read/29331307/risk-factors-of-sensorineural-hearing-loss-in-patients-with-unilateral-safe-chronic-suppurative-otitis-media
#2
Abd Elrheem Ahmed Singer, Osama G Abdel-Naby Awad, Rafeek Mohamed Abd El-Kader, Ahmed Rabeh Mohamed
PURPOSE: Chronic suppurative otitis media (CSOM) is the major cause of hearing impairment, especially conductive hearing loss. Few patients also had sensorineural component, the sensorineural hearing loss (SNHL) in CSOM is controversial, especially for safe mucosal type. This study aims to assess the relationship between the frequency of SNHL development in patients with safe mucosal CSOM and its relation to patient's age, sex, duration of disease, size of perforation and different audiological findings...
January 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29322063/neurological-sequelae-of-adult-meningitis-in-africa-a-systematic-literature-review
#3
REVIEW
Drew W Goldberg, Mark W Tenforde, Hannah K Mitchell, Joseph N Jarvis
The high human immunodeficiency virus (HIV) prevalence in sub-Saharan Africa has markedly changed the epidemiology and presentation of adult meningitis. We conducted a systematic review using PubMed, Embase, Ovid, CENTRAL, and African Index Medicus to identify studies in Africa with data on neurological outcomes in adults after meningitis. We found 22 articles meeting inclusion criteria. From 4 studies with predominately pneumococcal meningitis, a median of 19% of survivors experienced hearing loss up to 40 days...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29315185/vestibular-function-and-gross-motor-development-in-195-children-with-congenital-hearing-loss-assessment-of-inner-ear-malformations
#4
Yusuke Kimura, Takeshi Masuda, Kimitaka Kaga
OBJECTIVES: To evaluate the relationship between vestibular function and gross motor development in children with inner ear malformations. METHODS: A total of 195 children (average age: 2.4 ± 1.6 yr) with profound hearing loss, defined as a hearing threshold greater than 80 dB, participated in this study. Evaluation of vestibular function was assessed in all children using a damped rotational chair test. Gross motor development was assessed by examining the age of acquisition of head control and independent walking...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29315086/six2-gene-haploinsufficiency-leads-to-a-recognizable-phenotype-with-ptosis-frontonasal-dysplasia-and-conductive-hearing-loss
#5
Alina Henn, Harald Weng, Simon Novak, Günther Rettenberger, Andreas Gerhardinger, Eva Rossier, Birgit Zirn
Heterozygous microdeletions of chromosome 2p21 encompassing only the SIX2 gene have been described in two families to date. The clinical phenotype comprised autosomal-dominant inherited frontonasal dysplasia with ptosis in one family. In the second family, conductive hearing loss was the major clinical feature described; however, the affected persons also had ptosis. Here, we present a large family combining all three predescribed features of SIX2 gene deletion. The phenotype in four affected family members in three generations consisted of bilateral congenital ptosis, epicanthus inversus, frontonasal dysplasia with broad nasal bridge and hypertelorism, frontal bossing and large anterior fontanel in childhood, narrow ear canals, and mild conductive hearing loss with onset in childhood...
January 8, 2018: Clinical Dysmorphology
https://www.readbyqxmd.com/read/29313370/bilateral-ossicular-head-dehiscence-into-the-middle-cranial-fossa
#6
Sameer A Alvi, Joel W Jones, Jim Lin
OBJECTIVES: To describe a unique case of bilateral dehiscence of the malleus and incus heads into the middle fossa making contact with the temporal lobes, along with its clinical implications. METHODS: An analysis of a patient case and review of pertinent literature were performed. RESULTS: A patient with a history of right-sided mastoidectomy for cholesteatoma was evaluated for persistent conductive hearing loss. On computed tomography (CT) and magnetic resonance imaging (MRI), the patient had a complete dehiscence of the tegmen tympani on the right, with ossicular heads being located above the floor of the middle cranial fossa...
January 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29313308/noise-pollution-and-impact-on-children-health
#7
REVIEW
Alok Gupta, Anant Gupta, Khushbu Jain, Sweta Gupta
With rapid urbanization and life style changes, loud noise is omnipresent and has become a part of life. Indoor and outdoor environmental noise pollution have been documented as a serious health hazard with increasing adverse effects on fetus, infants, children, adolescents and adults. Noise induced hearing loss and non-auditory adverse effects due to noise pollution, are being increasingly diagnosed in all age groups including the fetus. Outdated motorized vehicles, machinery, increasing traffic, congested residential areas, crowded educational institutions and workplaces, unregulated commercial and industrial noise have become a source of noise pollution with long-term disability...
January 9, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29306226/does-fibromyalgia-have-an-effect-on-hearing-loss-in-women
#8
Zeliha Kapusuz Gencer, Özlem Balbaloğlu, Mahmut Özkırış, Levent Saydam
Background/aim: Fibromyalgia (FM) patients may have several neuroendocrine dysfunctions, resulting in a hypervigilant sensory output that may be responsible for sensorineural complaints. In this study, we evaluated the audiological findings of a cohort of female fibromyalgia patients. Materials and methods: Between 1 September 2012 and 1 June 2013, 35 female FM patients, followed by the Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bozok University, were recruited for the study. The patients were referred to the Department of Otolaryngology for routine otolaryngological and audiological evaluations...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29298522/is-non-linear-frequency-compression-amplification-beneficial-to-adults-and-children-with-hearing-loss-a-systematic-review
#9
Gladys Atinuke Akinseye, Ann-Marie Dickinson, Kevin J Munro
OBJECTIVE: To conduct a systematic review of the benefits of non-linear frequency compression (NLFC) in adults and children. DESIGN: Ten databases were searched for studies comparing the effects of NLFC and conventional processing (CP) for the period January 2008 to September 2017. STUDY SAMPLE: Twelve articles were included in this review: four adults and school-aged only, one pre-school only and three with both adults and school-aged children...
January 3, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29297800/auditory-evoked-potentials-and-behavioral-considerations-with-hearing-loss-in-small-cetaceans-application-as-a-standard-diagnostic-test-in-health-assessment
#10
Megan M Strobel, Dorian S Houser, Kathleen T Moore, Michelle R Davis, Patricia L Clough, Lydia A Staggs, Holli C Eskelinen, Robin J Bates, Michael T Walsh
The primary sense in odontocetes is hearing and a large portion of the odontocete brain is devoted to the auditory processing of echolocation signals. Hearing deficits in odontocetes potentially compromise the ability to forage, navigate, socialize, and evade predators. This presents a challenge to survival and reproduction in wild odontocetes and can affect the general welfare of odontocetes under human care. Currently, little empirical information on how odontocete behavior is affected by hearing loss exists...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29287859/hearing-loss-in-children-with-primary-ciliary-dyskinesia
#11
Kathryn L Kreicher, Heather K Schopper, Akash N Naik, Jonathan L Hatch, Ted A Meyer
OBJECTIVES: To evaluate the type and severity of hearing impairment in pediatric patients with primary ciliary dyskinesia (PCD) and relate these measures to patient demographics, treatment options, and other otologic factors. METHODS: A retrospective analysis of children with a diagnosis of PCD, Kartagener's syndrome, or situs inversus in the AudGen Database was conducted. Audiograms were analyzed for type of hearing loss (HL), severity, laterality, and progression...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29287854/systematic-review-of-knowledge-of-attitudes-towards-and-practices-for-newborn-hearing-screening-among-healthcare-professionals
#12
REVIEW
Rohit Ravi, Dhanshree R Gunjawate, Krishna Yerraguntla, Bellur Rajashekhar
INTRODUCTION: The success of newborn hearing screening programs lies in the timely identification, diagnosis, and management of children with hearing loss accomplished via a multidisciplinary newborn hearing screening (NHS) team. The team is typically comprised of various healthcare professionals who act as decision makers as well as facilitators for different stages in the screening process. Team members' knowledge of, attitudes towards, and practices for early hearing detection and intervention programs are critical for success and prevention of loss to follow up...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29287847/targeted-next-generation-sequencing-identified-a-novel-mutation-in-myo7a-causing-usher-syndrome-type-1-in-an-iranian-consanguineous-pedigree
#13
Daniz Kooshavar, Masoumeh Razipour, Morteza Movasat, Mohammad Keramatipour
BACKGROUND: Usher syndrome (USH) is characterized by congenital hearing loss and retinitis pigmentosa (RP) with a later onset. It is an autosomal recessive trait with clinical and genetic heterogeneity which makes the molecular diagnosis much difficult. In this study, we introduce a pedigree with two affected members with USH type 1 and represent a cost and time effective approach for genetic diagnosis of USH as a genetically heterogeneous disorder. METHODS: Target region capture in the genes of interest, followed by next generation sequencing (NGS) was used to determine the causative mutations in one of the probands...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29285614/the-effects-of-quinine-on-neurophysiological-properties-of-dopaminergic-neurons
#14
Li Zou, Yingchao Xue, Michael Jones, Thomas Heinbockel, Mingyao Ying, Xiping Zhan
Quinine is an antimalarial drug that is toxic to the auditory system by commonly inducing hearing loss and tinnitus, presumably due to its ototoxic effects on disruption of cochlear hair cells and blockade of ion channels of neurons in the auditory system. To a lesser extent, quinine also causes ataxia, tremor, and dystonic reactions. As dopaminergic neurons are implicated to play a role in all of these diseases, we tested the toxicity of quinine on induced dopaminergic (iDA) neurons derived from human pluripotent stem cells (iPSCs) and primary dopaminergic (DA) neurons of substantia nigra from mice brain slices...
December 29, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29283102/use-of-vasodilators-in-idiopathic-sudden-sensorineural-hearing-loss-a-systematic-review
#15
REVIEW
Melissa Bravenboer de Sousa, Selma Cazemier, Inge Stegeman, Hans Thomeer
To compare the effect of vasodilators with that of corticosteroids in patients with idiopathic sudden sensorineural hearing loss (ISSHL). A search in PubMed, Cochrane, and Embase was conducted. Two reviewers screened the data sources to identify articles that comply with predefined inclusion criteria. Studies that compared the therapeutic effect of vasodilators with prednisone or placebo in patients with ISSHL were identified. Five articles were selected, involving a total of 611 patients. The odds ratios for perceptive hearing levels (pure tone average) post treatment varied between 0...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29283093/anterior-cervical-disc-fusion-does-not-affect-the-presence-of-cervical-vestibular-evoked-myogenic-potential
#16
Ioannis Kastanioudakis, Panagiotis Saravakos, Andreas Zigouris, Vasileios Ragos, Oliver Reichel, Nafsika Ziavra
OBJECTIVE: Cervical spondylosis and cervical disk herniation are the most frequent forms of degenerative disease in the cervical spine. Surgical treatment mainly includes anterior cervical disk fusion. However, information concerning vestibular-evoked myogenic potential (VEMP) recording in patients undergoing cervical spine surgery is limited. The present prospective study aimed to investigate the effect of anterior disk fusion surgery on cervical VEMP (cVEMP) parameters. MATERIALS AND METHODS: Twenty-five patients were enrolled in this study, and 20 patients (10 men and 10 women) completed cVEMP testing...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29281905/identifying-factors-associated-with-mobility-decline-among-hospitalized-older-adults
#17
Jo-Ana D Chase, Alicia Lozano, Alexandra Hanlon, Kathryn H Bowles
Hospitalization can negatively affect mobility among older adults. Early detection of older patients most at risk for mobility decline can lead to early intervention and prevention of mobility loss. This study's purpose was to identify factors from the International Classification of Functioning, Disability, and Health associated with mobility decline among hospitalized elders. We conducted a secondary analysis of data from 959 hospitalized adults age 65 and older. We estimated the effects of health conditions and environmental and personal factors on mobility decline using logistic regression...
February 2018: Clinical Nursing Research
https://www.readbyqxmd.com/read/29279724/implantable-hearing-devices
#18
REVIEW
Matthias Tisch
Combined hearing loss is an essential indication for implantable hearing systems. Depending on the bone conduction threshold, various options are available. Patients with mild sensorineural deafness usually benefit from transcutaneous bone conduction implants (BCI), while percutaneous BCI systems are recommended also for moderate hearing loss. For combined hearing losses with moderate and high-grade cochlear hearing loss, active middle ear implants are recommended. For patients with incompatibilities or middle ear surgery, implants are a valuable and proven addition to the therapeutic options...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/29278615/risk-for-speech-and-language-impairments-in-pre-school-aged-hiv-exposed-uninfected-children-with-in-utero-combination-antiretroviral-exposure
#19
Mabel L Rice, Jonathan S Russell, Toni Frederick, Murli Purswani, Paige L Williams, George K Siberry, Sean M Redmond, Howard J Hoffman, Tzy-Jyun Yao
BACKGROUND: Perinatally HIV-exposed but uninfected (HEU) children have elevated risk of late language emergence at age 1 year, with possible links to in utero antiretroviral (ARV) exposure. We investigated possible risks for speech impairments (SI) and language impairments (LI) in preschool monolingual HEU children in the United States. METHODS: Speech and language assessments were conducted as part of the PHACS Surveillance Monitoring of ART Toxicities (SMARTT) study at ages 3 (N= 208) and 5 (N = 429) years...
December 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29273441/mri-screening-of-the-internal-auditory-canal-is-gadolinium-necessary-to-detect-intralabyrinthine-schwannomas
#20
Johnathan C Valesano, Carrie M Carr, Laurence J Eckel, Matthew L Carlson, John I Lane
OBJECTIVE: Non-contrast MRI of the internal auditory canal (IAC) using high-resolution T2WI (T2 weighted image) has been proposed as the primary screening study in patients with sudden or asymmetric sensorineural hearing loss (ASNHL). However, there are concerns that non-contrast MRI may not detect labyrinthine pathology, specifically intralabyrinthine schwannomas (ILSs). The purpose of this study was to determine if non-contrast high-resolution T2WI alone are adequate to exclude these uncommon intralabyrinthine tumors...
December 13, 2017: American Journal of Otolaryngology
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