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https://www.readbyqxmd.com/read/28806779/a-mutation-in-nischarin-causes-otitis-media-via-limk1-and-nf-%C3%AE%C2%BAb-pathways
#1
Michael Crompton, Tom Purnell, Hayley E Tyrer, Andrew Parker, Greg Ball, Rachel E Hardisty-Hughes, Richard Gale, Debbie Williams, Charlotte H Dean, Michelle M Simon, Ann-Marie Mallon, Sara Wells, Mahmood F Bhutta, Martin J Burton, Hilda Tateossian, Steve D M Brown
Otitis media (OM), inflammation of the middle ear (ME), is a common cause of conductive hearing impairment. Despite the importance of the disease, the aetiology of chronic and recurrent forms of middle ear inflammatory disease remains poorly understood. Studies of the human population suggest that there is a significant genetic component predisposing to the development of chronic OM, although the underlying genes are largely unknown. Using N-ethyl-N-nitrosourea mutagenesis we identified a recessive mouse mutant, edison, that spontaneously develops a conductive hearing loss due to chronic OM...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28806342/cognitive-abilities-and-quality-of-life-after-cochlear-implantation-in-the-elderly
#2
Marie-Hortense Sonnet, Bettina Montaut-Verient, Jean-Yves Niemier, Michel Hoen, Laurence Ribeyre, Cécile Parietti-Winkler
OBJECTIVE: To evaluate quality of life (QoL) and cognitive function in elderly patients with cochlear implants relative to auditory improvement, using geriatric validated scales. STUDY DESIGN: Prospective observational study. SETTING: A tertiary referral center for cochlear implantation (CI) and a geriatric center in Nancy, France. PATIENTS: Sixteen consecutive patients were included, from 65 to 80 years old, with postlingual severe-to-profound deafness...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28802383/absence-of-kcnq4-mutation-in-bengali-families-with-adnshl-originated-from-west-bengal-india
#3
Bidisha Adhikary, Biswabandhu Bankura, Subhradev Biswas, Silpita Paul, Madhusudan Das
OBJECTIVE: Autosomal Dominant Non-Syndromic Hearing Loss (ADNSHL) is extremely heterogeneous in nature. More than 60 loci with 30 different genes have been identified linked to ADNSHL. Mutation in KCNQ4 is considered as one of the most common causative factor responsible for ADNSHL. No study focused on the genetic alteration of KCNQ4 gene among hearing loss patients in India. The present study for the first time was carried out to determine the mutation spectrum of KCNQ4 gene in ADNSHL patients of West Bengal state, India...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28802353/hearing-loss-in-children-with-growth-hormone-deficiency
#4
John S Muus, Forest W Weir, Kathryn L Kreicher, Deborah A Bowlby, Christopher M Discolo, Ted A Meyer
OBJECTIVE: Although insulin-like growth factor 1 (IGF-1) has been shown to be important for inner-ear development in animal models, little is known about the otologic and audiologic findings of children with growth hormone deficiency (GHD). The goal of this study is to evaluate the prevalence, type, and severity of hearing impairment in children with GHD. METHODS: Audiologic, otologic, and demographic data were recorded for children with a diagnosis of GHD in the AudGen database...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28800372/alveolar-and-postalveolar-voiceless-fricative-and-affricate-productions-of-spanish-english-bilingual-children-with-cochlear-implants
#5
Fangfang Li, Ferenc Bunta, J Bruce Tomblin
Purpose: This study investigates the production of voiceless alveolar and postalveolar fricatives and affricates by bilingual and monolingual children with hearing loss who use cochlear implants (CIs) and their peers with normal hearing (NH). Method: Fifty-four children participated in our study, including 12 Spanish-English bilingual CI users (M = 6;0 [years;months]), 12 monolingual English-speaking children with CIs (M = 6;1), 20 bilingual children with NH (M = 6;5), and 10 monolingual English-speaking children with NH (M = 5;10)...
August 11, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28799451/radiological-clinical-and-audiological-evaluation-of-jugular-bulb-vestibular-aqueduct-dehiscence
#6
Asli Tanrivermis Sayit, Muzaffer Elmali, Ozgur Kemal, Yuksel Terzi
OBJECTIVE: The aim of this study is to determine the prevalence of jugular bulb-vestibular aqueduct dehiscence (JBVAD) in patients undergoing temporal bone multidetector computed tomography (MDCT) and assess the relationship between JBVAD and hearing loss with the findings of audiometry. METHODS: About 1503 temporal bone MDCT scans were evaluated for the prevalence of JBVAD. Correlation of the imaging findings and audiometric data was performed. Patients were divided into two groups, those with and those without hearing loss, and were statistically compared...
August 11, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28796850/the-economic-impact-of-adult-hearing-loss-a-systematic-review
#7
Matthew G Huddle, Adele M Goman, Faradia C Kernizan, Danielle M Foley, Carrie Price, Kevin D Frick, Frank R Lin
Importance: Hearing impairment (HI) is highly prevalent in older adults and has been associated with adverse health outcomes. However, the overall economic impact of HI is not well described. Objective: The goal of this review was to summarize available data on all relevant costs associated with HI among adults. Evidence Review: A literature search of PubMed, Embase, the Cochrane Library, CINAHL, and Scopus was conducted in August 2015. For this systematic review, data extraction and quality assessment were performed by 2 independent reviewers...
August 10, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28794847/neuro-otological-and-peripheral-nerve-involvement-in-fabry-disease
#8
Sergio Carmona, Romina Weinschelbaum, Ana Pardal, Cintia Marchesoni, Paz Zuberbuhler, Patricia Acosta, Guillermo Cáceres, Isaac Kisinovsky, Luciana Bayón, Ricardo Reisin
Fabry disease (FD) is an X-linked lysosomal storage disease, with multisystemic glycosphingolipids deposits. Neuro-otological involvement leading to hearing loss and vestibular dysfunctions has been described, but there is limited information about the frequency, site of lesion, or the relationship with peripheral neuropathy. The aim was to evaluate the presence of auditory and vestibular symptoms, and assess neurophysiological involvement of the VIII cranial nerve, correlating these findings with clinical and neurophysiological features of peripheral neuropathy...
July 18, 2017: Audiology Research
https://www.readbyqxmd.com/read/28792529/discrepancy-between-self-assessed-hearing-status-and-measured-audiometric-evaluation
#9
So Young Kim, Hyung-Jong Kim, Min-Su Kim, Bumjung Park, Jin-Hwan Kim, Hyo Geun Choi
OBJECTIVE: The purpose of this study was to examine the difference between self-reported hearing status and hearing impairment assessed using conventional audiometry. The associated factors were examined when a concordance between self-reported hearing and audiometric measures was lacking. METHODS: In total, 19,642 individuals ≥20 years of age who participated in the Korea National Health and Nutrition Examination Surveys conducted from 2009 through 2012 were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28791082/protective-effect-of-nigella-sativa-oil-on-acoustic-trauma-induced-hearing-loss-in-rats
#10
Belde Culhaoglu, Selim S Erbek, Seyra Erbek, Evren Hizal
Acoustic trauma is a common reason for hearing loss. Different agents are used to prevent the harmful effect of acoustic trauma on hearing. The aim of this study was to evaluate the potential preventive effect of Nigella sativa (black cumin) oil in acoustic trauma. Our experimental study was conducted with 20 Sprague Downey female rats (mean age, 12 months; mean weight 250 g). All of the procedures were held under general anesthesia. Following otoscopic examinations, baseline-hearing thresholds were obtained using auditory brainstem responses (ABR)...
July 18, 2017: Audiology Research
https://www.readbyqxmd.com/read/28780465/investigating-the-race-for-the-surface-and-skin-integration-in-clinically-retrieved-abutments-with-two-photon-microscopy
#11
D Kapsokalyvas, M van Hoof, S Wigren, T Chimhanda, H J Kuijpers, F C S Ramaekers, R J Stokroos, M A M J van Zandvoort
Bone conduction hearing implants can rehabilitate some types of hearing loss. A hydroxyapatite (HA)-coated skin-penetrating abutment was developed to allow for soft tissue preservation and increased skin-abutment adherence. Inflammation is thought to relate to bacterial infection of pockets around the abutment. Upon integration, the host's ability to cover the abutment surface ("race for the surface"), and thus control and prevent competitive bacteria from colonizing it, is improved. However, the attachment mechanisms behind it are not clear...
July 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28780171/disappearance-of-contralateral-dominant-neural-activity-of-auditory-cortex-after-single-sided-deafness-in-adult-rats
#12
Min Young Lee, Doo Hee Kim, Su-Kyoung Park, Sang Beom Jun, Yena Lee, Jun-Jae Choi, Hyun Ji Yoo, Yehoash Raphael, Seung-Ha Oh
Hearing loss in mature ears can cause functional reorganization of the auditory cortex. The functional reorganization is speculated to negatively affect the outcome of hearing rehabilitation. Therefore, once a hearing loss occurs, it is important to provide auditory input before extensive reorganization in the auditory pathways. We investigated the neural plasticity in auditory cortex after single-sided deafness (SSD) in an adult rat model. The animals were divided into two groups: a normal hearing (NH) and the SSD group...
August 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28777905/decompression-sickness-among-diving-fishermen-in-mexico-observational-retrospective-analysis-of-dcs-in-three-sea-cucumber-fishing-seasons
#13
Oswaldo Huchim-Lara, Walter Chin, Silvia Salas, Normando Rivera-Canul, Salvador Cordero-Romero, Juan Tec, Ellie Joo, Nina Mendez-Dominguez
The probabilities of decompression sickness (DCS) among diving fishermen are higher than in any other group of divers. Diving behavior of artisanal fishermen has been directed mainly to target high-value species. The aim of this study was to learn about the occurrence of DCS derived from sea cucumber harvesting in the Yucatán Peninsula, Mexico. We conducted a retrospective chart review of diving fishermen treated at a multiplace hyperbaric chamber in Tizimín, Mexico. In total, 233 recompression therapies were rendered to 166 diving fishermen from 2014 to 2016...
March 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28777515/early-treatment-response-predicts-outcome-in-patients-with-idiopathic-sudden-sensorineural-hearing-loss-treated-with-hyperbaric-oxygen-therapy
#14
Iclal Karatop-Cesur, Gunalp Uzun, Kubra Ozgok-Kangal, Mesut Mutluoglu, Senol Yildiz
Hyperbaric oxygen (HBO₂) therapy is used in the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL). Some patients, however, do not benefit from HBO₂ therapy despite several weeks of treatment. We hypothesized that early treatment response could predict treatment failure. We conducted a retrospective chart review and identified patients diagnosed with ISSNHL and recorded the pure tone average (PTA) levels prior to, after the first week and at completion of HBO₂ therapy. Early treatment response (ETR) was assessed after the first week of HBO₂ therapy, and an increase ⟨10 decibels (dB) in mean PTA level was defined as a negative ETR...
November 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28776715/cost-effectiveness-of-pediatric-bilateral-cochlear-implantation-in-spain
#15
Jorge Pérez-Martín, Miguel A Artaso, Francisco J Díez
OBJECTIVES/HYPOTHESIS: To determine the incremental cost-effectiveness of bilateral versus unilateral cochlear implantation for 1-year-old children suffering from bilateral sensorineural severe to profound hearing loss from the perspective of the Spanish public health system. STUDY DESIGN: Cost-utility analysis. METHODS: We conducted a general-population survey to estimate the quality-of-life increase contributed by the second implant. We built a Markov influence diagram and evaluated it for a life-long time horizon with a 3% discount rate in the base case...
August 4, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28762345/assessment-of-dental-caries-and-periodontal-status-in-institutionalized-hearing-impaired-children-in-khordha-district-of-odisha
#16
Avinash Jnaneswar, Goutham Bala Subramaniya, Jayashree Pathi, Kunal Jha, Vinay Suresan, Gunjan Kumar
INTRODUCTION: Over 5% of the world's population has disabling hearing loss. The oral health of the disabled may be disused for the reason of the disabling condition, a challenging disease or the limited access to oral health care. OBJECTIVES: The objectives of the study were to assess the prevalence of dental caries and periodontal status of institutionalized hearing impaired (HI) children in Khordha district of Odisha. MATERIALS AND METHODS: A descriptive cross-sectional study on the HI children was conducted in Khordha district, Odisha...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28760859/sound-evoked-activity-influences-myelination-of-brainstem-axons-in-the-trapezoid-body
#17
James L Sinclair, Matthew J Fischl, Olga Alexandrova, Martin Heß, Benedikt Grothe, Christian Leibold, Conny Kopp-Scheinpflug
Plasticity of myelination represents a mechanism to tune the flow of information by balancing functional requirements with metabolic and spatial constraints. The auditory system is heavily myelinated and operates at the upper limits of action potential generation frequency and speed observed in the mammalian CNS. This study aimed to characterize the development of myelin within the trapezoid body, a central auditory fiber tract, and determine the influence sensory experience has on this process in mice of both sexes...
July 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28756570/sensitivity-and-specificity-of-the-abbreviated-profile-of-hearing-aid-benefit-aphab
#18
Jan Löhler, F Gräbner, B Wollenberg, P Schlattmann, R Schönweiler
Subjective hearing loss in hearing-impaired patients can be assessed by inventory questionnaires. The abbreviated profile of hearing aid benefit (APHAB) measures subjective hearing loss in four typical hearing situations (subscales). It is used to fit hearing aids in patients with statutory insurance in Germany. In addition, the unaided APHAB (APHABu) can be used as a primary diagnostic instrument in audiology. There are no published data regarding the sensitivity and specificity of the unaided APHABu. Therefore, we investigated these parameters for detecting hearing loss of at least 25 dB at any frequency between 0...
July 29, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28750130/prevalence-of-hearing-loss-among-children-9-to-11-years-old-the-generation-r-study
#19
Carlijn M P le Clercq, Gijs van Ingen, Liesbet Ruytjens, André Goedegebure, Henriette A Moll, Hein Raat, Vincent W V Jaddoe, Rob J Baatenburg de Jong, Marc P van der Schroeff
Importance: Hearing loss (HL), a major cause of disability globally, negatively affects both personal and professional life. Objective: To describe the prevalence of sensorineural hearing loss (SNHL) among a population-based cohort of 9- to 11-year-old children, and to examine potential associations between purported risk factors and SNHL in early childhood. Design, Setting, and Participants: The study was among the general, nonclinical, pediatric community within the city of Rotterdam, the Netherlands, and was conducted between 2012 and 2015 as a cross-sectional assessment within the Generation R Study, a population-based longitudinal cohort study from fetal life until adulthood...
July 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28738977/glutathione-peroxidase-3-gene-polymorphisms-and-the-risk-of-sudden-sensorineural-hearing-loss
#20
Chen-Yu Chien, Tzu-Yen Huang, Shu-Yu Tai, Ning-Chia Chang, Hsun-Mo Wang, Ling-Feng Wang, Kuen-Yao Ho
The glutathione peroxidase 3 gene (GPX3) is reported to be a risk factor for arterial ischaemic stroke and cerebral venous thrombosis. GPX3 may be one of the aetiologies of sudden sensorineural hearing loss (SSNHL), which might be attributed to the genetic effect of GPX3 by influence reactive oxygen species (ROS). Unbalanced ROS have been associated with susceptibility to SSNHL. Therefore, we conducted a case-control study with 416 SSNHL cases and 255 controls. Five single nucleotide polymorphisms (SNPs) were selected...
July 2017: Kaohsiung Journal of Medical Sciences
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