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https://www.readbyqxmd.com/read/28088539/the-dna-damage-response-of-c-elegans-affected-by-gravity-sensing-and-radiosensitivity-during-the-shenzhou-8-spaceflight
#1
Ying Gao, Dan Xu, Lei Zhao, Yeqing Sun
Space radiation and microgravity are recognized as primary and inevitable risk factors for humans traveling in space, but the reports regarding their synergistic effects remain inconclusive and vary across studies due to differences in the environmental conditions and intrinsic biological sensitivity. Thus, we studied the synergistic effects on transcriptional changes in the global genome and DNA damage response (DDR) by using dys-1 mutant and ced-1 mutant of C. elegans, which respectively presented microgravity-insensitivity and radiosensitivity when exposure to spaceflight condition (SF) and space radiation (SR)...
January 7, 2017: Mutation Research
https://www.readbyqxmd.com/read/28088011/particulates-and-noise-exposure-during-bicycle-bus-and-car-commuting-a-study-in-three-european-cities
#2
Enembe O Okokon, Tarja Yli-Tuomi, Anu W Turunen, Pekka Taimisto, Arto Pennanen, Ilias Vouitsis, Zissis Samaras, Marita Voogt, Menno Keuken, Timo Lanki
BACKGROUND: In order to curb traffic-related air pollution and its impact on the physical environment, contemporary city commuters are encouraged to shift from private car use to active or public transport modes. However, personal exposures to particulate matter (PM), black carbon and noise during commuting may be substantial. Therefore, studies comparing exposures during recommended modes of transport versus car trips are needed. METHODS: We measured personal exposure to various-sized particulates, soot, and noise during commuting by bicycle, bus and car in three European cities: Helsinki in Finland, Rotterdam in the Netherlands and Thessaloniki in Greece using portable monitoring devices...
January 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28086893/seasonal-variation-in-geographical-access-to-maternal-health-services-in-regions-of-southern-mozambique
#3
Prestige Tatenda Makanga, Nadine Schuurman, Charfudin Sacoor, Helena Edith Boene, Faustino Vilanculo, Marianne Vidler, Laura Magee, Peter von Dadelszen, Esperança Sevene, Khátia Munguambe, Tabassum Firoz
BACKGROUND: Geographic proximity to health facilities is a known determinant of access to maternal care. Methods of quantifying geographical access to care have largely ignored the impact of precipitation and flooding. Further, travel has largely been imagined as unimodal where one transport mode is used for entire journeys to seek care. This study proposes a new approach for modeling potential spatio-temporal access by evaluating the impact of precipitation and floods on access to maternal health services using multiple transport modes, in southern Mozambique...
January 13, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/28086845/the-social-determinants-of-tuberculosis-treatment-adherence-in-a-remote-region-of-papua-new-guinea
#4
Tanya Diefenbach-Elstob, David Plummer, Robert Dowi, Sinba Wamagi, Bisato Gula, Keyanato Siwaeya, Daniel Pelowa, Peter Siba, Jeffrey Warner
BACKGROUND: Papua New Guinea (PNG) is a diverse and culturally-rich country with severe infrastructural and health problems. Tuberculosis (TB) is widespread, and the number of cases with drug resistance is rising. Treatment adherence is known to be important for both effective treatment and limiting the emergence of drug resistance. The aim of this study was to construct a matrix of the factors that act as facilitators or barriers to TB treatment adherence in a remote region of PNG. METHODS: The study was based in the Balimo region of the Western Province...
January 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28086810/genotypic-characterization-of-orientia-tsutsugamushi-from-patients-in-two-geographical-locations-in-sri-lanka
#5
Ranjan Premaratna, Lucas S Blanton, Dilhar N Samaraweera, G Nalika N de Silva, Nilmini T G A Chandrasena, David H Walker, H J de Silva
BACKGROUND: To date more than 20 antigenically distinct strains of Orientia tsutsugamushi (OT) reported within the tsutsugamushi triangle that cause an undifferentiated acute febrile illness in humans. Genotypic characterization of OT in different geographic regions or within the same country, is important in order to establish effective diagnostics, clinical management and to develop effective vaccines. Genetic and antigenic characterization of OT causing human disease in OT-endemic regions is not known for Sri Lanka...
January 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28080959/sentinel-surveillance-of-imported-dengue-via-travellers-to-europe-2012-to-2014-tropnet-data-from-the-denguetools-research-initiative
#6
Andreas Neumayr, Jose Muñoz, Mirjam Schunk, Emmanuel Bottieau, Jakob Cramer, Guido Calleri, Rogelio López-Vélez, Andrea Angheben, Thomas Zoller, Leo Visser, Núria Serre-Delcor, Blaise Genton, Francesco Castelli, Marjan Van Esbroeck, Alberto Matteelli, Laurence Rochat, Elena Sulleiro, Florian Kurth, Federico Gobbi, Francesca Norman, Ilaria Torta, Jan Clerinx, David Poluda, Miguel Martinez, Antonia Calvo-Cano, Maria Paz Sanchez-Seco, Annelies Wilder-Smith, Christoph Hatz, Leticia Franco
We describe the epidemiological pattern and genetic characteristics of 242 acute dengue infections imported to Europe by returning travellers from 2012 to 2014. The overall geographical pattern of imported dengue (South-east Asia > Americas > western Pacific region > Africa) remained stable compared with 1999 to 2010. We isolated the majority of dengue virus genotypes and epidemic lineages causing outbreaks and epidemics in Asia, America and Africa during the study period. Travellers acted as sentinels for four unusual dengue outbreaks (Madeira, 2012-13; Luanda, 2013; Dar es Salaam, 2014; Tokyo, 2014)...
January 5, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28079840/re-preparing-pediatric-international-travelers-for-travelers-diarrhea-insights-from-the-global-travepinet
#7
Miguel O'Ryan, Eli Schwartz, Shai Ashkenazi
No abstract text is available yet for this article.
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28079839/preparing-pediatric-international-travelers-for-travelers-diarrhea-insights-from-the-global-travepinet
#8
Stefan H F Hagmann, Regina C LaRocque, Edward T Ryan
No abstract text is available yet for this article.
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28078993/mirnas-new-biomarkers-and-therapeutic-targets-in-dementia
#9
Ana Teresa de Bastos Viegas, Joana Ribeiro Guedes, Ana Rafaela Oliveira, Ana Maria Sequeira Cardoso, Ana Luísa Colaço Cardoso
BACKGROUND: Dementia is a complex pathological state that affects millions of individuals worldwide and is responsible for a huge socioeconomic burden, making it a major health concern of current times. Given the impact of dementia in both patients and caregivers, it is crucial to fully clarify the molecular mechanisms underlying dementia-associated disorders, since without this knowledge our ability to correctly diagnose and treat these diseases is severely hampered. METHODS: Epigenetic mechanisms, such as miRNA-mediated post-transcriptional regulation, have been reported to play a role in dementia pathogenesis...
January 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28078983/cutaneous-larva-migrans
#10
Alexander K C Leung, Benjamin Barankin, Kam Lun Hon
BACKGROUND: Cutaneous larva migrans is one of the most common skin diseases reported in travelers returning from tropical regions. Western physicians, however, are often not familiar of this condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications, and treatment of cutaneous larva migrans. METHODS: A PubMed search was completed in Clinical Queries using the key term "cutaneous larva migrans"...
January 10, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28078947/monitoring-of-plasmodium-infection-in-humans-and-potential-vectors-of-malaria-in-a-newly-emerged-focus-in-southern-iran
#11
Mohsen Kalantari, Zahra Soltani, Mostafa Ebrahimi, Masoud Yousefi, Masoumeh Amin, Ayda Shafiei, Kourosh Azizi
Despite control programs, which aim to eliminate malaria from Iran by 2025, transmission of malaria has not been removed from the country. This study aimed to monitor malaria from asymptomatic parasitaemia and clinical cases from about one year of active case surveillance and potential vectors of malaria in the newly emerged focus of Mamasani and Rostam, southern Iran during 2014-2015. Samples were collected and their DNAs were extracted for Polymerase Chain Reaction (PCR) assay using specific primers for detection of Plasmodium species...
January 12, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28078718/fabric-based-alkaline-direct-formate-microfluidic-fuel-cells
#12
Kryls Domalaon, Catherine Tang, Alex Mendez, Franky Bernal, Krutarth Purohit, Linda Pham, John Haan, Frank A Gomez
Fabric-based microfluidic fuel cells (MFCs) serve as a novel, cost-efficient alternative to traditional FCs and batteries, since fluids naturally travel across fabric via capillary action, eliminating the need for an external pump and lowering production and operation costs. Building on previous research with Y-shaped paper-based MFCs, fabric-based MFCs mitigate fragility and durability issues caused by long periods of fuel immersion. In the present work we describe a microfluidic fabric-based direct formate fuel cell (DFFC), with 5 M potassium formate and 30% hydrogen peroxide as the anode fuel and cathode oxidant, respectively...
January 12, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28078485/a-simple-method-for-improving-the-spatial-resolution-in-infrared-laser-ablation-mass-spectrometry-imaging
#13
Juha-Pekka Hieta, Anu Vaikkinen, Samuli Auno, Heikki Räikkönen, Markus Haapala, Gianmario Scotti, Jaakko Kopra, Petteri Piepponen, Tiina J Kauppila
In mass spectrometry imaging of tissues, the size of structures that can be distinguished is determined by the spatial resolution of the imaging technique. Here, the spatial resolution of IR laser ablation is markedly improved by increasing the distance between the laser and the focusing lens. As the distance between the laser and the lens is increased from 1 to 18 m, the ablation spot size decreases from 440 to 44 μm. This way, only the collimated center of the divergent laser beam is directed on the focusing lens, which results in better focusing of the beam...
January 11, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28077839/atypical-trigeminal-neuralgia-a-rare-neurological-manifestation-of-systemic-lupus-erythematosus
#14
Viki Kumar, Jaspinder Kaur, Pallavi Pothuri, Sahiba Bandagi
BACKGROUND Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder of unknown etiology which can present at any age with symptoms of mucocutaneous, musculoskeletal, renal, central nervous system, and nonspecific clinical pictures making the disease a "master of mimicry". CASE REPORT A 53-year-old female, who was recently diagnosed with SLE, presented with right-sided sharp and electric shock-like facial pain starting at the side of her right nostril and traveling down the naso-labial fold and then back to the angle of the jaw, mostly in the region of V2-V3 distribution with no radiation beyond trigeminal distribution...
January 12, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28077749/survey-of-obstetrician-gynecologists-in-the-united-states-about-taeniasis-and-cysticercosis
#15
Rebecca L Hall, Britta Anderson, Jay Schulkin, Paul T Cantey, Susan P Montgomery, Jeffrey L Jones
An estimated 50 million persons worldwide are infected with cysticerci, the larval forms of the Taenia solium tapeworm. Neurocysticercosis can cause seizures, epilepsy, and hydrocephalus, and fatal cases have been reported in the United States in immigrants and in travelers returning from endemic countries. Pregnant women with symptomatic neurocysticercosis present treatment challenges, whereas those with the adult tapeworm infection (i.e., taeniasis) can put their infants and other family members, as well as obstetrician-gynecologists and their staff, at risk for cysticercosis...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28077742/colonization-factors-in-enterotoxigenic-escherichia-coli-strains-in-travelers-to-mexico-guatemala-and-india-compared-with-children-in-houston-texas
#16
Vineetkumar B Kharat, Makhdum Ahmed, Zhi-Dong Jiang, Mark S Riddle, Herbert L DuPont
Enterotoxigenic Escherichia coli (ETEC) can be attributed to around 200 million diarrheal episodes and 380,000 deaths in the developing regions. Travelers' diarrhea occurs in 15-40% of travelers to developing regions with ETEC being the most important etiologic agent. This study aims to describe the distribution of enterotoxins and colonization factor (CF) profiles of ETEC isolates from stool samples of adult travelers acquiring diarrhea in Mexico, Guatemala, and India and a group of children with acute diarrhea in Houston, TX, between 2007 and 2012...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28077609/travellers-and-influenza-risks-and-prevention
#17
REVIEW
M Goeijenbier, P van Genderen, B J Ward, A Wilder-Smith, R Steffen, A D M E Osterhaus
BACKGROUND: Influenza viruses are among the major causes of serious human respiratory tract infection worldwide. In line with the high disease burden attributable to influenza, these viruses play an important, but often neglected, role in travel medicine. Guidelines and recommendations regarding prevention and management of influenza in travellers are scarce. Of special interest for travel medicine are risk populations and also circumstances that facilitate influenza virus transmission and spread, like travel by airplane or cruise ship and mass gatherings...
January 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28077608/-holiday-sickness-reported-exploratory-outcome-of-over-500-united-kingdom-holidaymakers-with-travellers-diarrhoea
#18
Prof Aali J Sheen, M Saad B Zahid, Andrew Fagbemi, Catherine Fullwood, Kathryn Whitehead
AIMS: To ascertain any predictors of potential food poisoning pathogens and development of post-infective irritable bowel syndrome (IBS) in UK travellers. An analysis was undertaken on prospectively collected data on 527 patients reporting symptoms of suspected food poisoning between June 2012 and June 2015. MAIN OUTCOME MEASURES: Positive stool sample indicative of food poisoning pathogens and diagnosis of post-infective IBS. RESULTS: Data on 527 patients were examined...
January 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28077481/splenomegaly-in-the-returning-traveller-a-diagnostic-workup
#19
Priya Umesh Patel, Padmini Sastry, Muhammad Jawad
Isolated splenomegaly is an unusual condition encompassing a broad range of diagnoses. We report a case of a 38-year-old Asian man who presented with insidious abdominal discomfort and night sweats following recent travel to India. Massive splenomegaly was the only prominent feature on clinical examination and on subsequent imaging. Extensive investigations were performed, ultimately resulting in transfer to a tertiary centre for definitive diagnosis via a splenic biopsy. A fine-needle aspiration was performed, and revealed diffuse large B-cell lymphoma (DLBCL)...
January 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28076589/time-volunteered-on-community-health-activities-by-brigadistas-in-nicaragua
#20
Meredith Adamo, Dixmer Rivera, Rashed Shah, Jeanne Koepsell, Leonel Martínez, Justo Pastor Ortiz, Carlos José Jarquín Navarrete, David R Marsh
Objective: To report on how brigadistas ("health brigadiers") in Nicaragua volunteer their time before the introduction of expanded responsibilities (beyond the scope of integrated community case management (iCCM)) for sick children 2-59 months old. Methods: Three complete teams of brigadistas (n = 12 brigadistas total) were selected from remote communities in the department of Matagalpa. Each respondent brigadista was interviewed privately regarding the frequency and duration (i...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
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