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https://www.readbyqxmd.com/read/29679540/the-free-energy-of-biomembrane-and-nerve-excitation-and-the-role-of-anesthetics
#1
Tian Wang, Tea Mužić, Andrew D Jackson, Thomas Heimburg
In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference necessary to induce a phase transition in the nerve membrane. It is a function of temperature and pressure, and it is sensitively dependent on the presence of anesthetics which lower melting transitions. We investigate the free energy difference of solid and liquid membrane phases under the influence of anesthetics...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29679362/anatomical-variation-in-the-form-of-inter-and-intra-individual-laterality-of-the-calcaneofibular-ligament
#2
Hisayoshi Yoshizuka, Kentaro Shibata, Toyoko Asami, Akio Kuraoka
The lateral ligament complex of the ankle is involved in a large proportion of ankle sprains. The calcaneofibular ligament (CFL) is often involved in severe injuries. The purpose of this study was to evaluate the anatomical variation and laterality of the CFL to improve our understanding of the mechanisms of CFL-related injuries. This study utilized 110 paired ankles from 55 formalin-fixed Japanese cadavers (33 male and 22 female). The length and width of the CFL and the angle created by the CFL and long axis of the fibula (CF angle) were measured after exposing the CFL by careful dissection from the surrounding tissues...
April 20, 2018: Anatomical Science International
https://www.readbyqxmd.com/read/29679104/local-action-on-outdoor-air-pollution-to-improve-public-health
#3
REVIEW
Sotiris Vardoulakis, Rachel Kettle, Paul Cosford, Paul Lincoln, Stephen Holgate, Jonathan Grigg, Frank Kelly, David Pencheon
OBJECTIVES: The National Institute for Health and Care Excellence, jointly with Public Health England, have developed a guideline on outdoor air pollution and its links to health. The guideline makes recommendations on local interventions that can help improve air quality and prevent a range of adverse health outcomes associated with road-traffic-related air pollution. METHODS: The guideline was based on a rigorous assessment of the scientific evidence by an independent advisory committee, with input from public health professionals and other professional groups...
April 20, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29678885/the-burden-of-neurothrombectomy-call-a-multicenter-prospective-study
#4
Michelle M Williams, Taylor A Wilson, Thabele Leslie-Mazwi, Joshua A Hirsch, Ryan T Kellogg, Alejandro M Spiotta, Reade De Leacy, J Mocco, Felipe Albuquerque, Andrew F Ducruet, Adam Arthur, Visish M Srinivasan, Peter Kan, Maxim Mokin, Travis M Dumont, Alan Reeves, Jasmeet Singh, Stacey Q Wolfe, Kyle M Fargen
INTRODUCTION: Neurothrombectomy frequency is increasing, and a better understanding of the neurothrombectomy call burden is needed. METHODS: Neurointerventional physicians at nine participating stroke centers prospectively recorded time requirements for all neurothrombectomy (NT) consultations over 30 consecutive 24 hour call periods. RESULTS: Data were collected from a total of 270 days of call. 214 NT consultations were reported (mean 0...
April 20, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29678616/costs-of-community-based-interventions-from-the-community-transformation-grants
#5
Olga A Khavjou, Amanda A Honeycutt, Benjamin Yarnoff, Christina Bradley, Robin Soler, Diane Orenstein
Limited data are available on the costs of evidence-based community-wide prevention programs. The objective of this study was to estimate the per-person costs of strategies that support policy, systems, and environmental changes implemented under the Community Transformation Grants (CTG) program. We collected cost data from 29 CTG awardees and estimated program costs as spending on labor; consultants; materials, travel, and services; overhead activities; partners; and the value of in-kind contributions. We estimated costs per person reached for 20 strategies...
April 17, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29678494/household-food-waste-collection-building-service-networks-through-neighborhood-expansion
#6
William R Armington, Roger B Chen
In this paper we develop a residential food waste collection analysis and modeling framework that captures transportation costs faced by service providers in their initial stages of service provision. With this framework and model, we gain insights into network transportation costs and investigate possible service expansion scenarios faced by these organizations. We solve a vehicle routing problem (VRP) formulated for the residential neighborhood context using a heuristic approach developed. The scenarios considered follow a narrative where service providers start with an initial neighborhood or community and expands to incorporate other communities and their households...
April 17, 2018: Waste Management
https://www.readbyqxmd.com/read/29678361/chikungunya-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#7
Pravin Amin, Gisele Sampaio Silva, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Dilip R Karnad, Guy A Richards
Chikungunya is an arbovirus that is transmitted by the Aedes mosquito causing a febrile illness with periodic outbreaks in large parts of the world. In the last decade it has become a public health concern in a host of countries and has affected international tourists. In the vast majority of cases Chikungunya presents as an acute febrile illness, associated with rash, headache, myalgia and debilitating arthralgia or even polyarthritis. A small proportion of patients present atypically with nervous, ocular, renal, myocardial, respiratory and renal system involvement and may require ICU management...
April 7, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29676814/potential-of-carnosine-a-histamine-precursor-in-rat-model-of-bilateral-common-carotid-artery-occlusion-induced-vascular-dementia
#8
Nidhi Tiwari, Pankaj Bhatia, Amit Kumar, Amteshwar S Jaggi, Nirmal Singh
The present study investigates the potential of Carnosine a histamine precursor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. The rats were subjected to Morris water-maze (MWM) test (6th day onwards post-surgery). MWM test was employed to assess learning and memory of the animals whereby ELT (escape latency time), TSTQ (time spent in target quadrant) and Path length (distance travelled) taken as important parameters...
April 20, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29676715/-european-reference-networks-for-rare-diseases
#9
J R Vos, W A G van Zelst-Stams, N Hoogerbrugge
Approximately one million patients in the Netherlands and 27-36 million patients in Europe have one of the 5,000-8,000 known rare diseases. These patients often do not receive the care they need or with a substantial delay from diagnosis to treatment. As of March 2017, 24 European Reference Networks (ERNs) were launched with the aim to improve the care for these patients through cross-border healthcare, where in principle the knowledge travels and not the patient. It is expected that through the ERNs, European patients with a rare disease get more often and more quickly access to expert care and that it will accelerate guideline development and research...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676052/rapamycin-protects-against-early-brain-injury-independent-of-cerebral-blood-flow-changes-in-a-mouse-model-of-subarachnoid-haemorrhage
#10
Kazumasu Sasaki, Shuzo Yamamoto, Tatsushi Mutoh, Yoshiharu Tsuru, Yasuyuki Taki, Ryuta Kawashima
We evaluated the neuroprotective role of rapamycin, a mammalian target of rapamycin (mTOR) kinase inhibitor, in cerebral ischaemia and locomotor function in a mouse model of subarachnoid haemorrhage (SAH). Pretreatment with rapamycin, a mTOR kinase inhibitor, resulted in better recovery from cerebral hypoxia early after SAH than control (P < .05), while the values of peak flow velocity in the middle cerebral artery did not change significantly (P > .05). The ratio of central-area distance/total travelled distance determined by open-field test after day 14 was significantly higher in mice pretreated with rapamycin than in control mice (P < ...
April 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29675570/driving-ability-after-right-sided-puncture-of-the-common-femoral-artery-during-coronary-angiography
#11
Christoph Brenner, Raoul Fuehring, David Niederseer, Rudolf Kirchmair, Christian Haid, Michael Liebensteiner
OBJECTIVES/BACKGROUND: To assess brake reaction time (BRT; key factor in driving ability) in patients receiving transfemoral coronary angiography (CAG). We assumed that patients would have a significantly impaired BRT after the procedure. METHODS: A prospective, observational study design was applied. Consecutive patients undergoing right-sided transfemoral CAG as part of the clinical routine were included. An experimental driving simulator was used to determine BRT after receiving a visual stimulus...
April 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29674252/predicting-enrollment-in-two-randomized-controlled-trials-of-nonpharmacologic-interventions-for-youth-with-primary-mood-disorders
#12
Andrea S Young, Adina M Seidenfeld, K Zachary Healy, L Eugene Arnold, Mary A Fristad
BACKGROUND: As recruitment and retention are often challenging in randomized controlled trials (RCTs), this study sought to identify predictors of participation (i.e., trial enrollment). METHOD: These analyses identified predictors of enrollment among 119 youth, ages 7-14, with a primary mood disorder, who screened eligible for the Omega-3 and Therapy pilot studies; 95 (79.8%) actually participated in the treatment. RESULTS: Youth who received some form of travel assistance (16...
April 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29672873/space-time-analyses-of-alcohol-outlets-and-related-motor-vehicle-crashes-associations-at-city-and-census-block-group-levels
#13
Robert Lipton, William R Ponicki, Paul J Gruenewald, Andrew Gaidus
OBJECTIVES: Past research has linked alcohol outlet densities to drinking, drunken driving and alcohol-related motor vehicle crashes (MVCs). Because impaired drivers travel some distances from drinking places to crash locations, spatial relationships between outlets and crashes are complex. We investigate these relationships at three geographic levels: Census block groups (CBGs), adjacent (nearby) areas, and whole cities. METHODS: We examined risks for all injury MVCs as well as 'had been drinking' (HBD) and single-vehicle nighttime (SVN) subgroups using data from the Statewide Integrated Traffic Records System (SWITRS) across CBGs among 50 California cities from 2001 to 2008...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29672711/high-altitude-travel-and-mental-health
#14
Gerard T Flaherty, Chen Wei Chua
No abstract text is available yet for this article.
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29672709/surveillance-of-travel-associated-diseases-at-two-referral-centres-in-marseille-france-a-12-year-survey
#15
Karolina M Griffiths, Hélène Savini, Philippe Brouqui, Fabrice Simon, Philippe Parola, Philippe Gautret
Background: With increasing international travel and historically high numbers of residents visiting friends and relatives overseas, travel-associated illnesses are frequent in Marseille, France. We report the changing epidemiology of travel-related illnesses over a 12-year period. Methods: A single site GeoSentinel surveillance analysis was undertaken for 3460 ill returned travellers presenting to two public hospitals in Marseille, France from March 2003 to October 2015, with travel-related illnesses...
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29672708/do-prebiotics-reduce-the-risk-of-travellers-diarrhoea-promising-but-more-research-needed
#16
Bradley A Connor
No abstract text is available yet for this article.
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29671913/measuring-the-financial-and-productivity-burden-of-paediatric-hospitalisation-on-the-wider-family-network
#17
Virginia Mumford, Melissa T Baysari, Djala Kalinin, Magdalena Z Raban, Cheryl McCullagh, Jonathon Karnon, Johanna I Westbrook
AIM: To estimate the non-medical out-of-pocket costs for families with a child in hospital. METHODS: This study was a survey of 225 parents of paediatric inpatients on nine wards of an Australian public paediatric teaching hospital on two separate days. Our primary outcomes were the costs associated with: (i) time taken off work to care for the child in hospital; (ii) time off work or contributed by family and friends to care for other dependents; and (iii) travel, meals, accommodation and incidental expenses during the child's stay...
April 19, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29671067/vaccinations-in-pediatric-kidney-transplant-recipients
#18
REVIEW
Thomas G Fox, Corina Nailescu
Pediatric kidney transplant (KT) candidates should be fully immunized according to routine childhood schedules using age-appropriate guidelines. Unfortunately, vaccination rates in KT candidates remain suboptimal. With the exception of influenza vaccine, vaccination after transplantation should be delayed 3-6 months to maximize immunogenicity. While most vaccinations in the KT recipient are administered by primary care physicians, there are specific schedule alterations in the cases of influenza, hepatitis B, pneumococcal, and meningococcal vaccinations; consequently, these vaccines are usually administered by transplant physicians...
April 18, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29670984/magnetically-driven-omnidirectional-artificial-microswimmers
#19
Mojca Vilfan, Natan Osterman, Andrej Vilfan
We present an experimental realisation of two new artificial microswimmers that swim at low Reynolds number. The swimmers are externally driven with a periodically modulated magnetic field that induces an alternating attractive/repulsive interaction between the swimmer parts. The field sequence also modulates the drag on the swimmer components, making the working cycle non-reciprocal. The resulting net translational displacement leads to velocities of up to 2 micrometers per second. The swimmers can be made omnidirectional, meaning that the same magnetic field sequence can drive swimmers in any direction in the sample plane...
April 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29670815/transatlantic-air-travel-in-the-third-trimester-of-pregnancy-does-it-affect-the-fetus
#20
B Petrikovsky, M Terrani, L Sichinava
Most commercial airlines allow pregnant women to fly up to 36 weeks of gestation. Available information suggests that noise, vibration, and cosmic radiation present a small risk for the pregnant air traveler. The goal of the study was to assess the possible effect of transatlantic flights on the condition of the third-trimester fetus. In total, 112 patients were recruited into the study between January 2005 and June 2016. All underwent a transatlantic flight in the third trimester of pregnancy. All underwent nonstress test before and within 12 hours after the transatlantic flight, and 24 hours later...
April 2018: American Journal of Perinatology Reports
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