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https://www.readbyqxmd.com/read/29457381/a-multicentre-study-of-validity-and-reliability-of-responses-to-hand-cold-challenge-as-measured-by-laser-speckle-contrast-imaging-and-thermography-outcome-measures-for-systemic-sclerosis-related-raynaud-s-phenomenon
#1
Jack D Wilkinson, Sarah A Leggett, Elizabeth J Marjanovic, Tonia L Moore, John Allen, Marina E Anderson, Jason Britton, Maya H Buch, Francesco Del Galdo, Christopher P Denton, Graham Dinsdale, Bridgett Griffiths, Frances Hall, Kevin Howell, Audrey MacDonald, Neil J McHugh, Joanne B Manning, John D Pauling, Christopher Roberts, Jacqueline A Shipley, Ariane L Herrick, Andrea K Murray
BACKGROUND: Objective and reliable outcome measures to facilitate clinical trials of novel treatments for systemic sclerosis (SSc)-related Raynaud's phenomenon (RP) are badly needed. Laser speckle contrast imaging (LSCI) and thermography are non-invasive measures of perfusion that show excellent potential. The purpose of this multi-centre study was to determine the reliability and validity of a hand cold challenge protocol using LSCI, standard thermography and low-cost mobile phone-based thermography...
February 18, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29453582/the-clinical-phenotype-of-patients-positive-for-antibodies-to-myositis-and-myositis-related-disorders
#2
S G Gofrit, H Yonath, M Lidar, Y Shoenfeld, S Kivity
Inflammatory myopathies are a clinically diverse group of diseases, in which the detection of particular autoantibodies may facilitate diagnosis, treatment, and prognosis. The aim of this report is to summarize our experience with specific autoantibody testing in patients with inflammatory myopathies. Data were collected over the last decade in the Autoimmune Center of the Sheba Medical Center, a tertiary referral hospital. Data regarding patients' positive for autoantibodies against Jo-1, PL-7, PL-12, SRP, Mi-2, Ku, and PM-Scl antigens were retrospectively collected...
February 16, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29433114/-hepatitis-c-virus-induced-cryoglobulinemic-vasculitis
#3
Yasunori Minami, Masatoshi Kudo
Cryoglobulins are produced by the over-stimulated immune system of patients with hepatitis C virus (HCV). HCV-induced cryoglobulinemic vasculitis primarily affects small-sized vessels of systemic organs. The most common symptoms are purpura, joint pain, and peripheral neuropathy or Raynaud phenomenon. The blood tests of patients with HCV may exhibit raised erythrocyte sedimentation rate and C-reactive protein levels, positive rheumatoid factor and cryoglobulins, and decreased complement levels. Therapeutic options for HCV-induced cryoglobulinemic vasculitis, include anti-virals, Rituximab, steroids, immunosuppressant drugs, and plasma exchange...
February 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29429552/comment-renforcer-la-place-des-patients-dans-les-%C3%A3-valuations-des-technologies-de-sant%C3%A3-faites-par-les-autorit%C3%A3-s-de-sant%C3%A3
#4
Marie-France Mamzer, Sophie Dubois, Christian Saout, Nicolas Albin, Jehan-Michel Béhier, Anne Buisson, Vincent Diebolt, Olivier Delaitre, Christophe Duguet, Jean-Yves Fagon, Ségolène Gaillard, Claire Le Jeunne, René Mazars, Joëlle Micallef, Hervé Nabarette, Laurent Piazza, Catherine Raynaud, Nathalie Varoqueaux
No abstract text is available yet for this article.
December 11, 2017: Thérapie
https://www.readbyqxmd.com/read/29427827/nailfold-capillaroscopy-in-systemic-lupus-erythematosus-a-systematic-review-and-critical-appraisal
#5
REVIEW
Maurizio Cutolo, Karin Melsens, Sara Wijnant, Francesca Ingegnoli, Kristof Thevissen, Filip De Keyser, Saskia Decuman, Ulf Müller-Ladner, Yves Piette, Valeria Riccieri, Nicola Ughi, Els Vandecasteele, Amber Vanhaecke, Vanessa Smith
Nailfold capillaroscopy is an easy, non-invasive technique to assess microvascular involvement in rheumatic diseases. Multiple studies describe capillaroscopic changes in systemic lupus erythematosus (SLE), including a wide range of non-specific findings. On behalf of the European League Against Rheumatism (EULAR) study group on microcirculation in rheumatic diseases, a systematic review was done to obtain all original research studies (in English) in which SLE patients had capillaroscopy. Forty such studies are identified...
February 7, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29426682/retrospective-view-of-primary-raynaud-s-phenomenon-in-childhood
#6
Enes Turan, Sara Sebnem Kilic
OBJECTIVES: Primary Raynaud's phenomenon (PRP) manifests as episodes of transient spasms of peripheral blood vessels. To elucidate the clinical clues and laboratory characteristics will facilitate the identification of PRP. METHODS: A retrospective data collection of clinical and laboratory characteristics of 58 children with PRP was performed between January 2007 and December 2016. RESULTS: A positive ANA test at lower titers <1:100 was detected in 24...
February 6, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29425538/-etiological-profile-of-secondary-raynaud-s-phenomenon-in-an-internal-medicine-department-about-121-patients
#7
T Ben Salem, M Tougorti, S Bziouech, M Lamloum, M Khanfir, I Ben Ghorbel, M H Houman
INTRODUCTION: Raynaud's phenomenon is a reversible episodic vasospastic disorder triggered by cold or emotion. Two types of Raynaud's phenomenon were distinguished: Raynaud's disease and secondary Raynaud's phenomenon. The purpose of this study was to determine the etiologic profile of secondary Raynaud's phenomenon in an internal medicine department. METHODS: A descriptive retrospective study including patients with secondary Raynaud's phenomenon followed in a tertiary internal medicine department between 2000 and 2013...
February 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29425244/initiation-extension-and-termination-of-rna-synthesis-by-a-paramyxovirus-polymerase
#8
Paul C Jordan, Cheng Liu, Pauline Raynaud, Michael K Lo, Christina F Spiropoulou, Julian A Symons, Leo Beigelman, Jerome Deval
Paramyxoviruses represent a family of RNA viruses causing significant human diseases. These include measles virus, the most infectious virus ever reported, in addition to parainfluenza virus, and other emerging viruses. Paramyxoviruses likely share common replication machinery but their mechanisms of RNA biosynthesis activities and details of their complex polymerase structures are unknown. Mechanistic and functional details of a paramyxovirus polymerase would have sweeping implications for understanding RNA virus replication and for the development of new antiviral medicines...
February 9, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29417244/secondary-raynaud-s-phenomenon-and-skin-necrosis-of-toes-in-the-paraplegic-patient-with-hypertension
#9
Yong Jig Lee, Kisoo Park
We present two cases of paraplegic patients who developed secondary Raynaud's phenomenon. A 43-year-old man with paraplegia presented with dark purple discoloration and skin defects on his left second and third toes and complained of a cold sensation in both feet for a period of 1 year. He had been taking diuretics for 4 years. The capillary refilling time for both affected toes was delayed. His antihypertensive drug was changed to a calcium channel blocker under suspicion of Raynaud's phenomenon aggravated by hydrochlorothiazide, and the capillary refilling time normalized within 3 days...
February 7, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29409385/evidence-for-increase-in-finger-blood-flow-evaluated-by-laser-doppler-flowmetry-following-iloprost-infusion-in-patients-with-systemic-sclerosis-a-week-long-observational-longitudinal-study
#10
C Rotondo, M Nivuori, A Chialà, E Praino, M Matucci Cerinic, M Cutolo, G Lapadula, F Iannone
OBJECTIVES: Iloprost plays an important role in the treatment of Raynaud's phenomenon (RP), but has transient vasodilatory effects owing to its very short half-time. We aimed to evaluate short- and medium-term haemodynamic effects of iloprost by measuring dorsal finger microvessel blood flow using laser Doppler flowmetry (LDF), in patients with RP associated with systemic sclerosis (SSc). METHOD: In 24 consecutive SSc patients with RP (disease duration 10.5 ± 1...
February 7, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29408338/a-systematic-review-and-meta-analysis-of-the-effects-of-topical-nitrates-in-the-treatment-of-primary-and-secondary-raynaud-s-phenomenon
#11
Paul Curtiss, Zachary Schwager, Gabriela Cobos, Kristen Lo Sicco, Andrew G Franks
BACKGROUND: Multiple placebo controlled trials have assessed locally applied topical nitrate preparations in treating Raynaud's phenomenon (RP). OBJECTIVES: The objective of this meta-analysis was to assess the effects of local topical nitrates in primary and secondary RP with respect to a combined endpoint integrating parameters of digital blood flow and clinical severity. METHODS: A systematic review was performed using MEDLINE, Embase and the Cochrane library...
February 2, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29397675/risperidone-related-raynaud-s-phenomenon-an-adolescent-case
#12
Serkan Güneş, Özalp Ekinci, Halenur Teke, Veli Yıldırım
Raynaud's phenomenon is a recurrent vasospastic condition with reducing in peripheral blood flow due to cold, or emotional stress. White, blue and red discolorations occur during the attacks. Serotonin reuptake inhibitors, psychostimulants, and aripiprazole are reported to be related with Raynaud's phenomenon. Risperidone is an atypical antipsychotic drug with dopaminergic and serotonergic effects. In children and adolescents, risperidone is used for bipolar disorder, tic disorders, conduct disorder, schizophrenia, symptoms of irritability and self-mutilation...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29392863/stem-cell-transplant-in-systemic-sclerosis-an-indian-experience
#13
Velu Nair, Vivek Vasdev, Abhishek Kumar, Subramanian Shankar, Vivek Nair, Ajay Sharma
AIM: To prospectively evaluate long term outcomes in a cohort of patients with Systemic sclerosis treated with Hematopoietic stem cell transplant (HSCT). METHOD: This is a prospective observational study of four SSc patients who underwent HSCT at a tertiary care center in India between 2008-2012. The selection criteria included young individuals with rapidly progressive disease and at least one major organ involvement. We used granulocyte colony-stimulating factor for peripheral blood stem cell mobilization, pre-transplant conditioning with fludarabine, cyclophosphamide and rabbit anti-thymocyte globulin followed by re-infusion of autologous stem cells as per standard institute protocol...
February 2, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29392502/mosaic-capillaroscopic-findings-in-systemic-sclerosis
#14
Sevdalina Nikolova Lambova, Ulf Müller-Ladner
A 67-year-old woman with triphasic Raynaud's phenomenon since 2 years was diagnosed as having limited cutaneous systemic sclerosis (SSc) 1 year ago based on puffy fingers, positive antinuclear and anti-Scl-70 autoantibodies, and initial pulmonary fibrosis. Capillaroscopic examination revealed "mosaic" capillaroscopic findings that included normal pattern; "scleroderma"-type capillaroscopic pattern "early" phase, with single giant capillaries and haemorrhages, preserved capillary distribution; and "scleroderma"-type capillaroscopic pattern "active" phase, with high number of giant capillary loops and haemorrhages, moderately disturbed distribution...
February 1, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29390428/clinical-and-serological-features-of-systemic-sclerosis-in-a-multicenter-african-american-cohort-analysis-of-the-genome-research-in-african-american-scleroderma-patients-clinical-database
#15
Nadia D Morgan, Ami A Shah, Maureen D Mayes, Robyn T Domsic, Thomas A Medsger, Virginia D Steen, John Varga, Mary Carns, Paula S Ramos, Richard M Silver, Elena Schiopu, Dinesh Khanna, Vivien Hsu, Jessica K Gordon, Heather Gladue, Lesley A Saketkoo, Lindsey A Criswell, Chris T Derk, Marcin A Trojanowski, Victoria K Shanmugam, Lorinda Chung, Antonia Valenzuela, Reem Jan, Avram Goldberg, Elaine F Remmers, Daniel L Kastner, Fredrick M Wigley, Pravitt Gourh, Francesco Boin
Racial differences exist in the severity of systemic sclerosis (SSc). To enhance our knowledge about SSc in African Americans, we established a comprehensive clinical database from the largest multicenter cohort of African American SSc patients assembled to date (the Genome Research in African American Scleroderma Patients (GRASP) cohort).African American SSc patients were enrolled retrospectively and prospectively over a 30-year period (1987-2016), from 18 academic centers throughout the United States. The cross-sectional prevalence of sociodemographic, clinical, and serological features was evaluated...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390349/sj%C3%A3-gren-s-syndrome-manifesting-as-clinicopathological-features-of-tafro-syndrome-a-case-report
#16
Shino Fujimoto, Hiroshi Kawabata, Nozomu Kurose, Haruka Kawanami-Iwao, Tomoyuki Sakai, Takafumi Kawanami, Yoshimasa Fujita, Toshihiro Fukushima, Yasufumi Masaki
RATIONALE: TAFRO syndrome is a newly proposed disorder that manifests as thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. In this report, we describe the development of severe TAFRO syndrome-like systemic symptoms during the clinical course of juvenile-onset Sjögren's syndrome in a 32-year-old woman. PATIENT CONCERNS: The patient was admitted due to dyspnea, fever, polyarthralgia, and generalized edema. She had been diagnosed with Sjögren's syndrome at the age of 14 years, based on histopathological examination of a biopsy of the minor salivary glands and the development of Raynaud's phenomenon, with no follow-up treatment required...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390130/comment-on-reproducibility-of-the-scleroderma-pattern-assessed-by-wide-field-capillaroscopy-in-subjects-suffering-from-raynaud-s-phenomenon-reply
#17
Joël Constans, Sophie Blaise, Isabelle Lazareth, Claire Le Hello, Marc-Antoine Pistorius, Bernard Imbert, Marion Mangin, Pierre Sintes, Patricia Senet, Joelle Decamps-Le Chevoir, Laurent Tribout, Patrick Carpentier, Carine Boulon
No abstract text is available yet for this article.
January 29, 2018: Rheumatology
https://www.readbyqxmd.com/read/29390117/comment-on-reproducibility-of-the-scleroderma-pattern-assessed-by-wide-field-capillaroscopy-in-raynaud-s-phenomenon-patients
#18
Siamak Sabour
No abstract text is available yet for this article.
January 29, 2018: Rheumatology
https://www.readbyqxmd.com/read/29388433/annals-express-post-hoc-analysis-of-plasma-amino-acid-profiles-towards-a-specific-pattern-in-autism-spectrum-disorder-and-intellectual-disability
#19
Jean-Baptiste Delaye, Franck Patin, Emmanuelle Lagrue, Olivier Le Tilly, Clement Bruno, Marie-Laure Vuillaume, Martine Raynaud, Isabelle Benz-de Bretagne, Frederic Laumonnier, Patrick Vourc'h, Christian Andres, Helene Blasco
Objectives Autism Spectrum Disorders (ASD) and Intellectual Disability (ID) present a challenge for therapeutic and dietary management. We performed a re-analysis of plasma amino acid chromatography (AAC) of children with ASD (n=22) or ID (n=29) to search for a metabolic signature that can distinguish individuals with these disorders from controls (n=30). Methods We performed univariate and multivariate analysis using different machine learning strategies, from the raw data of the AAC. Finally, we analyzed the metabolic pathways associated with discriminant biomarkers...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29359173/immune-myopathies-with-perimysial-pathology-clinical-and-laboratory-features
#20
Robert C Bucelli, Alan Pestronk
Objective: Immune myopathies with perimysial pathology (IMPP) have a combination of damage to perimysial connective tissue and muscle fiber necrosis, more prominent near the perimysium. We studied the clinical and laboratory correlates of patients with pathologically defined IMPP. Methods: This is a retrospective chart and pathology review of 57 consecutive patients with IMPP myopathology and, for comparison, 20 patients with dermatomyositis with vascular pathology (DM-VP)...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
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