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https://www.readbyqxmd.com/read/27912892/-mesocolic-excision-for-colonic-adenocarcinoma
#1
REVIEW
Clotilde Debove, Jérémie H Lefèvre, Yann Parc
On the same principle than total mesorectal excision in rectal cancer, the effect of complete mesocolic excision on short and long-term outcomes is actually evaluated for colonic adenocarcinoma. This method, usually performed for left colectomy, offers a surgical specimen of higher quality, with a larger number of lymph nodes harvested. For right colectomy, surgical specifications make it less common complete mesocolic excision and conventional surgery offer comparable outcomes, as regards to postoperative morbidity and mortality rates...
November 29, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27895416/practice-guidelines-for-the-pathological-diagnosis-of-primary-liver-cancer-2015-update
#2
REVIEW
Wen-Ming Cong, Hong Bu, Jie Chen, Hui Dong, Yu-Yao Zhu, Long-Hai Feng, Jun Chen, Guideline Committee
In 2010, a panel of Chinese pathologists reported the first expert consensus for the pathological diagnosis of primary liver cancers to address the many contradictions and inconsistencies in the pathological characteristics and diagnostic criteria for PLC. Since then considerable clinicopathological studies have been conducted globally, prompting us to update the practice guidelines for the pathological diagnosis of PLC. In April 18, 2014, a Guideline Committee consisting of 40 specialists from seven Chinese Societies (including Chinese Society of Liver Cancer, Chinese Anti-Cancer Association; Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Pathology, Chinese Anti-Cancer Association; Digestive Disease Group, Chinese Society of Pathology, Chinese Medical Association; Chinese Society of Surgery, Chinese Medical Association; Chinese Society of Clinical Oncology, Chinese Anti-Cancer Association; Pathological Group of Hepatobiliary Tumor and Liver Transplantation, Chinese Society of Pathology, Chinese Medical Association) was created for the formulation of the first guidelines for the standardization of the pathological diagnosis of PLC, mainly focusing on the following topics: gross specimen sampling, concepts and diagnostic criteria of small hepatocellular carcinoma (SHCC), microvascular invasion (MVI), satellite nodules, and immunohistochemical and molecular diagnosis...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27890291/principles-and-applications-of-surgical-oncology-in-exotic-animals
#3
REVIEW
Michele A Steffey
The diagnosis and treatment of cancer in exotic species is a rapidly evolving area of veterinary medicine. In general, surgical excision remains pivotal in cancer treatment, although optimal outcomes are achieved when a coherent and thorough diagnostic and therapeutic plan is created prior to surgery. While surgical cure is not always achieveable, multimodal treatment plans can offer a variety of options, and palliative procedures may be used to improve quality of life. Treatment goals, whether curative intent or palliative intent, should be identified before surgery, and practitioners should endeavor to adhere to surgical principles in order to attain the best outcomes...
January 2017: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/27853982/spiritual-care-therapy-on-quality-of-life-in-cancer-patients-and-their-caregivers-a-prospective-non-randomized-single-cohort-study
#4
A Sankhe, K Dalal, V Agarwal, P Sarve
Spiritual care is still in infancy stage all over the globe including India. The present study was an original study evaluating the role of spiritual care in cancer patients and their primary caregivers regarding their spiritual and general well-being. The study was a prospective, non-randomized single-group study involving cancer patients undergoing surgery and their primary caregivers. Functional assessment of cancer therapy-general and functional assessment of chronic illness therapy-spiritual care was evaluated during the admission and at the time of discharge, two, four  and 6 months following discharge from the hospital...
November 16, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27849338/neck-dissections-emerging-role-of-oral-pathologists
#5
Madhusudan Astekar, Amolika Choube, Gaurav Sapra, Rajesh Kumar Chitlangiya
BACKGROUND: Surgical resection has been the principle treatment approach for early lesions as well as advanced stage carcinomas of upper aero digestive tract. Neck dissection is the primary treatment given to nodal metastasis of oral carcinomas. Choice of irradiation and chemotherapy post surgery relies heavily on the histopathological assessment of surgical margins of resected tumor, dissected lymph nodes and accessory tissues. METHODS: A total of ten cases of head and neck carcinomas reported in two years period were analyzed...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27846726/-new-technologies-for-in-vivo-cancer-diagnostics
#6
L Hernychova, D Coufalová, E Michalova, R Nenutil, B Vojtěšek
BACKGROUND: The treatment of oncological diseases is based on the combination of surgery, representing the key step for the removal of the tumor tissue, radiotherapy, chemotherapy, and hormone therapy. However, the surgery is often accompanied by issue of determining the boundaries of the tumor. Prior the operation, the surgeon has information on preoperative findings, which indicate the location and extent of the tumor, but does not specify a clear boundary between the tumor and healthy tissue...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27824248/robot-assisted-lymphadenectomy-in-urology-pelvic-retroperitoneal-and-inguinal-a-systematic-review
#7
Giovannalberto Pini, Surena F Matin, Nazareno Suardi, Mihir Desai, Inderbir Gill, James Porter, Robert J Stein, Rene Sotelo, Franco Gaboardi, Francesco Porpiglia
Lymph node dissection represents an essential surgical step in the treatment of the most commonly treated urological cancers. The introduction of robotic surgery has lead to the possibility of treating these diseases with a minimally invasive surgical approach, but the surgical principles of open surgery need to be carefully respected in order to achieve comparable oncological results. Therefore, the robotic approach to urological cancers must include a carefully performed lymph node dissection when indicated...
November 8, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27781239/-the-third-component-in-surgical-anatomy-and-its-impacts
#8
Jianping Gong
Surgical or local anatomy consists of two components conventionally, organs and their blood supply. In fact, they are enveloped by the fascia membrane and serous membrane. This is the third component in surgical or local anatomy, which is omitted by surgeons for many years. The omitted reasons are failed recognition and unknown function. Re-understanding of the third component in surgical or local anatomy will make some changes in the local anatomy, tumor pathology, oncology surgery and operations. Firstly, the third component makes surgical anatomy developed from organ anatomy, blood vessel anatomy to membrane anatomy, which consists of the mesentery in broad sense and its bed, both include serous membrane and fascia membrane...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27775302/-minimally-invasive-surgery-in-pediatric-oncology-tertiary-center-experience
#9
J Gómez-Chacón Villalba, L Rodríguez Caraballo, A Marco Macián, V Segarra Llido, J J Vila Carbó
AIMS: To describe our experience using Minimally Invasive Surgery (MIS) techniques in tertiary center with specific oncological pediatric surgery unit. METHODS: Retrospective review of patients undergoing MIS techniques in pediatric oncology surgery unit between January 2011 and December 2014. MIS procedures were considered made by both techniques such as laparoscopy and thoracoscopy with both diagnostic and therapeutic intent. RESULTS: 4 procedures were diagnostic and the rest were therapeutic: During the study, 56 procedures were performed by MIS...
July 20, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27765913/an-in-vitro-3d-bone-metastasis-model-by-using-a-human-bone-tissue-culture-and-human-sex-related-cancer-cells
#10
Francesca Salamanna, Veronica Borsari, Silvia Brogini, Gianluca Giavaresi, Annapaola Parrilli, Simona Cepollaro, Matteo Cadossi, Lucia Martini, Antonio Mazzotti, Milena Fini
One of the main limitations, when studying cancer-bone metastasis, is the complex nature of the native bone environment and the lack of reliable, simple, inexpensive models that closely mimic the biological processes occurring in patients and allowing the correct translation of results. To enhance the understanding of the mechanisms underlying human bone metastases and in order to find new therapies, we developed an in vitro three-dimensional (3D) cancer-bone metastasis model by culturing human breast or prostate cancer cells with human bone tissue isolated from female and male patients, respectively...
October 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27738626/cerenkov-luminescence-imaging-cli-for-image-guided-cancer-surgery
#11
M R Grootendorst, M Cariati, A Kothari, D S Tuch, A Purushotham
Cerenkov luminescence imaging (CLI) is a novel molecular optical imaging technique based on the detection of optical Cerenkov photons emitted by positron emission tomography (PET) imaging agents. The ability to use clinically approved tumour-targeted tracers in combination with small-sized imaging equipment makes CLI a particularly interesting technique for image-guided cancer surgery. The past few years have witnessed a rapid increase in proof-of-concept preclinical studies in this field, and several clinical trials are currently underway...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27702694/thoracic-endovascular-aortic-repair-for-embolizing-total-occlusion-of-the-descending-aorta-due-to-aortic-sarcoma
#12
Gabriele Piffaretti, Stefania Ferraro, Gianpaolo Carrafiello, Edoardo Macchi, Alessandro Bacuzzi, Patrizio Castelli
Primary malignant tumors of the aorta are extremely rare, and the diagnosis is difficult from the clinical onset. Accordingly to the principles of cancer surgery, "en bloc" resection of the tumor-involved aorta and graft interposition is the gold-standard, but it is still technically challenging and co-morbidities may rule out some patients from an operative treatment. Thoracic endovascular aortic repair has been reported anecdotally but it is an ease and rapid alternative in urgent circumstances, and proved to be effective to relieve symptoms caused by these lesions...
October 1, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27684746/transplantation-into-the-mouse-ovarian-fat-pad
#13
Andrea Flesken-Nikitin, Blaine A Harlan, Alexander Yu Nikitin
Orthotopic transplantation assays in mice are invaluable for studies of cell regeneration and neoplastic transformation. Common approaches for orthotopic transplantation of ovarian surface and tubal epithelia include intraperitoneal and intrabursal administration of cells. The respective limitations of these methods include poorly defined location of injected cells and limited space volume. Furthermore, they are poorly suited for long-term structural preservation of transplanted organs. To address these challenges, we have developed an alternative approach, which is based on the introduction of cells and tissue fragments into the mouse fat pad...
September 7, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27682158/reduction-mammoplasty-using-oxidized-regenerated-cellulose-as-a-filler-in-breast-conservation-surgery
#14
Gianluca Franceschini, Alejandro Martin Sanchez, Giuseppe Visconti, Alba Di Leone, Sabatino D'Archi, Antonino Mulè, Angela Santoro, Marzia Salgarello, Riccardo Masetti
: Oncoplastic surgery of the breast has generated great excitement over the past years and has become an integrated component of the surgical treatment of breast cancer. Oncoplastic procedures (OPP) associate the best surgical oncologic principles to achieve wide tumor-free margins with the best principles of plastic surgery to optimize cosmetic outcomes. So, a number of conventional mammoplasty techniques have been adapted to allow reconstruction of resection defects with parenchymal flaps using a variety of different approaches...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27629696/-training-course-transanal-total-mesorectal-excision-tatme-concept-and-establishment-of-a%C3%A2-training-course-for-safe-application
#15
F Aigner, M Biebl, A Fürst, T Jöns, J Pratschke, W Kneist
BACKGROUND: In recent years the video endoscopy-assisted transanal approach to total mesorectal excision (TME) combined with the conventional laparoscopic technique was developed as an alternative indication for treatment of low rectal cancer (TaTME). OBJECTIVE: The concept and results of the first German TaTME hands-on cadaver course with subsequent live surgery are presented. MATERIAL AND METHODS: The 2‑day training course was structured into an anatomical and a clinical surgery part...
September 15, 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27626365/patient-reported-outcomes-after-monitoring-surgery-or-radiotherapy-for-prostate-cancer
#16
Jenny L Donovan, Freddie C Hamdy, J Athene Lane, Malcolm Mason, Chris Metcalfe, Eleanor Walsh, Jane M Blazeby, Tim J Peters, Peter Holding, Susan Bonnington, Teresa Lennon, Lynne Bradshaw, Deborah Cooper, Phillipa Herbert, Joanne Howson, Amanda Jones, Norma Lyons, Elizabeth Salter, Pauline Thompson, Sarah Tidball, Jan Blaikie, Catherine Gray, Prasad Bollina, James Catto, Andrew Doble, Alan Doherty, David Gillatt, Roger Kockelbergh, Howard Kynaston, Alan Paul, Philip Powell, Stephen Prescott, Derek J Rosario, Edward Rowe, Michael Davis, Emma L Turner, Richard M Martin, David E Neal
Background Robust data on patient-reported outcome measures comparing treatments for clinically localized prostate cancer are lacking. We investigated the effects of active monitoring, radical prostatectomy, and radical radiotherapy with hormones on patient-reported outcomes. Methods We compared patient-reported outcomes among 1643 men in the Prostate Testing for Cancer and Treatment (ProtecT) trial who completed questionnaires before diagnosis, at 6 and 12 months after randomization, and annually thereafter...
October 13, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27587627/principles-of-treatment-for-borderline-micropapillary-serous-and-low-grade-ovarian-cancer
#17
REVIEW
Kari E Hacker, Shitanshu Uppal, Carolyn Johnston
Borderline ovarian tumors (BOTs) are less common than epithelial ovarian cancers (EOCs). Low-grade EOCs (LG-EOCs) occur even less frequently than BOTs. After primary therapy, recurrence rates of BOTs and LG-EOCs are significantly lower and the stage-adjusted survival is higher than for high-grade EOCs. Thus, determining the best management in terms of traditional ovarian cancer staging and debulking procedures is more challenging and has been recently brought to question. This article reviews the particulars of BOTs and LG-EOCs, their similarities and differences, and how they are best managed and treated, and emphasizes the major role of surgery and the controversial role of chemotherapy...
September 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27582646/endoluminal-therapy-in-colorectal-cancer
#18
REVIEW
Katherine A Kelley, V Liana Tsikitis
Appropriate endoscopic resection for colorectal polyps can present a challenge to endoscopists, as these lesions may harbor malignancy. With recent advances in endoscopy, however, we are now entering an exciting frontier of endoscopic therapy for gastrointestinal lesions. These techniques include endoluminal mucosal resection and endoscopic submucosal dissection, which may be utilized on several colonic lesions. This article will discuss these principle endoscopic techniques, their outcomes, and briefly highlight their influence on endoscopic interventions, including transanal endoscopic microsurgery and natural orifice transluminal endoscopic surgery...
September 2016: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/27579720/-3rd-hungarian-breast-cancer-consensus-conference-surgery-guidelines
#19
György Lázár, Attila Bursics, Zoltán Farsang, László Harsányi, Csaba Kósa, Róbert Maráz, Zoltán Mátrai, Attila Paszt, Gábor Pavlovics, Róbert Tamás
Therapy for breast cancer today is characterised by ever more precise diagnostic methods and ever more effective oncological treatments, a trend which will certainly continue in the future. Breast preservation and the application of oncoplastic principles are increasingly popular. A sentinel lymph node biopsy in the surgical treatment of the axilla is primary, with the indication for axillary block dissection (ABD) narrowing and radiation therapy becoming an alternative to ABD in certain cases. This publication summarises our recommendations on the surgical treatment of breast cancer based on the content of the 2nd Breast Cancer Consensus Conference and considering the latest international studies and professional recommendations...
September 2016: Magyar Onkologia
https://www.readbyqxmd.com/read/27576678/mirna-profiling-of-circulating-epcam-extracellular-vesicles-promising-biomarkers-of-colorectal-cancer
#20
Marie Stampe Ostenfeld, Steffen Grann Jensen, Dennis Kjølhede Jeppesen, Lise-Lotte Christensen, Stine Buch Thorsen, Jan Stenvang, Michael Lykke Hvam, Anni Thomsen, Peter Mouritzen, Mads Heilskov Rasmussen, Hans Jørgen Nielsen, Torben Falck Ørntoft, Claus Lindbjerg Andersen
Cancer cells secrete small membranous extracellular vesicles (EVs) into their microenvironment and circulation. These contain biomolecules, including proteins and microRNAs (miRNAs). Both circulating EVs and miRNAs have received much attention as biomarker candidates for non-invasive diagnostics. Here we describe a sensitive analytical method for isolation and subsequent miRNA profiling of epithelial-derived EVs from blood samples of patients with colorectal cancer (CRC). The epithelial-derived EVs were isolated by immunoaffinity-capture using the epithelial cell adhesion molecule (EpCAM) as marker...
2016: Journal of Extracellular Vesicles
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