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https://www.readbyqxmd.com/read/28922664/patchy-particles-made-by-colloidal-fusion
#1
Zhe Gong, Theodore Hueckel, Gi-Ra Yi, Stefano Sacanna
Patches on the surfaces of colloidal particles provide directional information that enables the self-assembly of the particles into higher-order structures. Although computational tools can make quantitative predictions and can generate design rules that link the patch motif of a particle to its internal microstructure and to the emergent properties of the self-assembled materials, the experimental realization of model systems of particles with surface patches (or 'patchy' particles) remains a challenge. Synthetic patchy colloidal particles are often poor geometric approximations of the digital building blocks used in simulations and can only rarely be manufactured in sufficiently high yields to be routinely used as experimental model systems...
September 18, 2017: Nature
https://www.readbyqxmd.com/read/28922309/quantifying-the-physiological-stress-response-to-simulated-maritime-pilotage-tasks-the-influence-of-task-complexity-and-pilot-experience
#2
Luana C Main, Alexander Wolkow, Timothy P Chambers
OBJECTIVE: The aim of this study was to quantify the stress associated with performing maritime pilotage tasks in a high-fidelity simulator. METHODS: Eight trainee and 13 maritime pilots completed two simulated pilotage tasks of varying complexity. Salivary cortisol samples were collected pre- and post-simulation for both trials. Heart rate was measured continuously throughout the study. RESULTS: Significant changes in salivary cortisol (P = 0...
September 15, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28922120/motion-estimation-in-echocardiography-using-sparse-representation-and-dictionary-learning
#3
Nora Ouzir, Adrian Basarab, Herve Liebgott, Brahim Harbaoui, Jean-Yves Tourneret
This paper introduces a new method for cardiac motion estimation in 2D ultrasound images. The motion estimation problem is formulated as an energy minimization, whose data fidelity term is built using the assumption that the images are corrupted by multiplicative Rayleigh noise. In addition to a classical spatial smoothness constraint, the proposed method exploits the sparse properties of the cardiac motion to regularize the solution via an appropriate dictionary learning step. The proposed method is evaluated on one dataset with available ground-truth, including four sequences of highly realistic simulations...
September 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28917963/an-efficient-computational-fluid-particle-dynamics-method-to-predict-deposition-in-a-simplified-approximation-of-the-deep-lung
#4
P G Koullapis, P Hofemeier, J Sznitman, S C Kassinos
High-fidelity simulations of the complete airway tree are still largely beyond current computational capabilities. Towards large-scale simulations of the human lung, the current study introduces a numerical methodology to predict particle deposition in a simplified approximation of the deep lung during a full breathing cycle. The geometrical model employed consists of an idealised bronchial tree that represents generations 10 to 19 of the conducting zone and an heterogeneous acinar model created using a space-filling algorithm...
September 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28915158/simulation-training-for-family-planning-procedures
#5
Lisa M Goldthwaite, Kristina Tocce
PURPOSE OF REVIEW: To review the current evidence for use of simulation in family planning procedural training. RECENT FINDINGS: A variety of simulation models exist for abortion, contraception, and sterilization procedures, ranging from low to high fidelity. Most models for abortion and contraception are low fidelity, inexpensive, and provide opportunities for acquisition and practice of procedural skills. Hysteroscopic and laparoscopic simulation models for sterilization procedures are generally higher fidelity, and their use has been shown to increase knowledge, skill performance, and procedural comfort...
September 14, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28913496/anaesthesiologists-simulation-training-during-emergencies-in-obstetrics
#6
Volodymyr V Artyomenko, Volodymyr M Nosenko
BACKGROUND AND AIMS: Methods of simulation training and quality assessment during obstetric emergencies are still ambiguous. The aim of this study was to evaluate the effectiveness of anaesthesiologists' simulation training for emergency situations in obstetrics. METHODS: We conducted a prospective, descriptive, and comparative study to evaluate the anaesthesiologists' simulation training effectiveness during obstetrical emergencies. Data of 109 obstetrical anaesthesiologists trained over two years for invasive procedures and cardiopulmonary resuscitation, high-fidelity scenarios and medical personnel teamwork included were analyzed...
April 2017: Rom J Anaesth Intensive Care
https://www.readbyqxmd.com/read/28891878/using-high-fidelity-simulation-and-video-assisted-debriefing-to-enhance-obstetrical-hemorrhage-mock-code-training
#7
Peggy J Jacobs
The purpose of this descriptive, one-group posttest study was to explore the nursing staff's perception of the benefits of using high-fidelity simulation during mandated obstetrical hemorrhage mock code training. In addition, the use of video-assisted debriefing was used to enhance the nursing staff's evaluation of their communication and teamwork processes during a simulated obstetrical crisis. The convenience sample of 84 members of the nursing staff consented to completing data collection forms and being videotaped during the simulation...
September 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28888157/nursing-students-evaluation-of-a-new-feedback-and-reflection-tool-for-use-in-high-fidelity-simulation-formative-assessment-of-clinical-skills-a-descriptive-quantitative-research-design
#8
Elisabeth Solheim, Hilde Syvertsen Plathe, Hilde Eide
Clinical skills training is an important part of nurses' education programmes. Clinical skills are complex. A common understanding of what characterizes clinical skills and learning outcomes needs to be established. The aim of the study was to develop and evaluate a new reflection and feedback tool for formative assessment. The study has a descriptive quantitative design. 129 students participated who were at the end of the first year of a Bachelor degree in nursing. After highfidelity simulation, data were collected using a questionnaire with 19 closed-ended and 2 open-ended questions...
September 4, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28887492/freeform-fabrication-of-tissue-simulating-phantom-for-potential-use-of-surgical-planning-in-conjoined-twins-separation-surgery
#9
Shuwei Shen, Haili Wang, Yue Xue, Li Yuan, Ximing Zhou, Zuhua Zhao, Erbao Dong, Bin Liu, Wendong Liu, Barrett Cromeens, Brent Adler, Gail Besner, Ronald X Xu
Preoperative assessment of tissue anatomy and accurate surgical planning is crucial in conjoined twin separation surgery. We developed a new method that combines three-dimensional (3D) printing, assembling, and casting to produce anatomic models of high fidelity for surgical planning. The related anatomic features of the conjoined twins were captured by computed tomography (CT), classified as five organ groups, and reconstructed as five computer models. Among these organ groups, the skeleton was produced by fused deposition modeling (FDM) using acrylonitrile-butadiene-styrene...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887485/direct-comparison-of-performance-of-single-nucleotide-variant-calling-in-human-genome-with-alignment-based-and-assembly-based-approaches
#10
Leihong Wu, Gokhan Yavas, Huixiao Hong, Weida Tong, Wenming Xiao
Complementary to reference-based variant detection, recent studies revealed that many novel variants could be detected with de novo assembled genomes. To evaluate the effect of reads coverage and the accuracy of assembly-based variant calling, we simulated short reads containing more than 3 million of single nucleotide variants (SNVs) from the whole human genome and compared the efficiency of SNV calling between the assembly-based and alignment-based calling approaches. We assessed the quality of the assembled contig and found that a minimum of 30X coverage of short reads was needed to ensure reliable SNV calling and to generate assembled contigs with a good coverage of genome and genes...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28885519/preparing-global-trauma-nurses-for-leadership-roles-in-global-trauma-systems
#11
Sol Angelica Muñiz, Richard W Lang, Lisa Falcon, Jasmine Garces-King, Suzanne Willard, Gregory L Peck
Trauma leads to 5.7 million annual deaths globally, accounting for 25%-33% of global unintentional deaths and 90% of the global trauma burden in low- and middle-income countries. The Lancet Commission on Global Surgery and the World Health Organization assert that emergent and essential surgical capacity building and trauma system improvement are essential to address the global burden of trauma. In response, the Rutgers Global Surgery program, the School of Nursing and Medicine, and the Robert Wood Johnson University Hospital faculty collaborated in the first Interprofessional Models in Global Injury Care and Education Symposium in June 2016...
September 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28882740/effect-of-sleep-deprivation-after-a-night-shift-duty-on-simulated-crisis-management-by-residents-in-anaesthesia-a-randomised-crossover-study
#12
Ségolène Arzalier-Daret, Clément Buléon, Marie-Laure Bocca, Pierre Denise, Jean-Louis Gérard, Jean-Luc Hanouz
BACKGROUND: Sleep deprivation has been associated with an increased incidence of medical errors and can jeopardise patients' safety during medical crisis management. The aim of the study was to assess the effect of sleep deprivation on the management of simulated anaesthesia crisis by residents in anaesthesiology. METHODS: A randomised, comparative, monocentric crossover study involving 48 residents in anaesthesia was performed on a high fidelity patient simulator...
September 4, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28878985/task-allocation-and-site-fidelity-jointly-influence-foraging-regulation-in-honeybee-colonies
#13
Thiago Mosqueiro, Chelsea Cook, Ramon Huerta, Jürgen Gadau, Brian Smith, Noa Pinter-Wollman
Variation in behaviour among group members often impacts collective outcomes. Individuals may vary both in the task that they perform and in the persistence with which they perform each task. Although both the distribution of individuals among tasks and differences among individuals in behavioural persistence can each impact collective behaviour, we do not know if and how they jointly affect collective outcomes. Here, we use a detailed computational model to examine the joint impact of colony-level distribution among tasks and behavioural persistence of individuals, specifically their fidelity to particular resource sites, on the collective trade-off between exploring for new resources and exploiting familiar ones...
August 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28877429/computational-simulations-of-dna-polymerases-detailed-insights-on-structure-function-mechanism-from-native-proteins-to-cancer-variants
#14
Alice R Walker, G Andres Cisneros
Genetic information is vital in the cell cycle of DNA--based organisms. DNA Polymerases (DNA Pols) are crucial players in transactions dealing with these processes. Therefore, the detailed understanding of the structure, function, and mechanism of these proteins has been the focus of significant effort. Computational simulations have been applied to investigate various facets of DNA polymerase structure and function. These simulations have provided significant insights over the years. This perspective presents the results of various computational studies that have been employed to research different aspects of DNA polymerases including detailed reaction mechanism investigation, mutagenicity of different metal cations, possible factors for fidelity synthesis, and discovery/functional characterization of cancer--related mutations on DNA polymerases...
September 6, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28876447/mask-ed-breaking-the-barrier-of-fear-of-intimate-care-for-nursing-students
#15
Kerry Reid-Searl, Barbara O'Neill
BACKGROUND: Nursing students learn to toilet, shower, and dress patients in the clinical laboratory with simulation modalities that lack the realism necessary to address the fears, values, and beliefs of nudity and intimate contact with patients. METHOD: A high-fidelity Mask-Ed™ (KRS [Knowledgeable, Realistic, Spontaneous] simulation) intervention was developed and piloted with first-year nursing students around patient showering to increase confidence and skills around intimate care...
September 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28874934/emergency-physician-performed-transesophageal-echocardiography-in-simulated-cardiac-arrest
#16
Don V Byars, Jordan Tozer, John M Joyce, Michael J Vitto, Lindsay Taylor, Turan Kayagil, Matt Jones, Matthew Bishop, Barry Knapp, David Evans
INTRODUCTION: Transesophageal echocardiography (TEE) is a well-established method of evaluating cardiac pathology. It has many advantages over transthoracic echocardiography (TTE), including the ability to image the heart during active cardiopulmonary resuscitation. This prospective simulation study aims to evaluate the ability of emergency medicine (EM) residents to learn TEE image acquisition techniques and demonstrate those techniques to identify common pathologic causes of cardiac arrest...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28873962/a-recurrence-based-approach-for-validating-structural-variation-using-long-read-sequencing-technology
#17
Xuefang Zhao, Alexandra M Weber, Ryan E Mills
Although numerous algorithms have been developed to identify structural variations (SVs) in genomic sequences, there is a dearth of approaches that can be used to evaluate their results. This is significant as the accurate identification of structural variation is still an outstanding but important problem in genomics. The emergence of new sequencing technologies that generate longer sequence reads can, in theory, provide direct evidence for all types of SVs regardless of the length of the region through which it spans...
August 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28873590/in-silico-analysis-and-molecular-docking-study-of-angiotensin-i-converting-enzyme-inhibitory-peptides-from-smooth-hound-viscera-protein-hydrolysates-fractionated-by-ultrafiltration
#18
Ola Abdelhedi, Rim Nasri, Letica Mora, Mourad Jridi, Fidel Toldrá, Moncef Nasri
Smooth-hound viscera hydrolysates (SHVHs) were prepared by treatment with Neutrase (SHVH-N) and Purafect (SHVH-P). Hydrolysates were then separated according to their molecular weight, using the ultra-filtration membrane system, into 5 fractions (≥50, 50-5, 5-3, 3-1 and ≤1kDa). Fractions showed different amino acid compositions and angiotensin I-converting enzyme (ACE) inhibitory potentials. The SHVH-P-FV (≤1kDa) and SHVH-N-FIV (3-1kDa) fractions showed the best ACE-inhibitory activities with IC50 values of 53...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28861850/novel-simulator-for-robotic-surgery
#19
Francisco Schlottmann, Marco G Patti
Surgical simulation avoids practicing skills in patients, allowing trainees to learn in a safe, controlled, and standardized environment. Current robotic surgical simulators available include virtual reality simulators, human cadavers, and live animals. The use of cadavers has the highest possible fidelity available to practice entire operations. Nevertheless, their cost, availability, tissue compliance, and infection risk outweigh the advantages of cadaver models. Drawbacks of using live animals include anatomical differences with humans, high costs due to their housing and handling requirements, and ethical concerns...
August 31, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28859651/video-based-feedback-as-a-method-for-training-rural-healthcare-workers-to-manage-medical-emergencies-a-pilot-study
#20
Zainab Oseni, Hla Hla Than, Edyta Kolakowska, Lauren Chalmers, Borimas Hanboonkunupakarn, Rose McGready
BACKGROUND: Video-based feedback has been shown to aid knowledge retention, skills learning and improve team functionality. We explored the use of video-based feedback and low fidelity simulation for training rural healthcare workers along the Thailand-Myanmar border and Papua New Guinea (PNG) to manage medical emergencies effectively. METHODS: Twenty-four study participants were recruited from three Shoklo Malaria Research Unit clinics along the Thailand-Myanmar border and eight participants from Kudjip Nazarene Hospital, PNG...
August 31, 2017: BMC Medical Education
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