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https://www.readbyqxmd.com/read/28227099/a-large-scale-detailed-neuronal-model-of-electrical-stimulation-of-the-dentate-gyrus-and-perforant-path-as-a-platform-for-electrode-design-and-optimization
#1
Clayton S Bingham, Kyle Loizos, Gene Yu, Andrew Gilbert, Jean-Marie Bouteiller, Dong Song, Gianluca Lazzi, Theodore W Berger, Clayton S Bingham, Kyle Loizos, Gene Yu, Andrew Gilbert, Jean-Marie Bouteiller, Dong Song, Gianluca Lazzi, Theodore W Berger, Kyle Loizos, Gene Yu, Theodore W Berger, Gianluca Lazzi, Jean-Marie Bouteiller, Clayton S Bingham, Dong Song, Andrew Gilbert
Owing to the dramatic rise in treatment of neurological disorders with electrical micro-stimulation it has become apparent that the major technological limitation in deploying effective devices lies in the process of designing efficient, safe, and outcome specific electrode arrays. The time-consuming and low-fidelity nature of gathering test data using experimental means and the immense control and flexibility of computational models, has prompted us and others to build models of electrical stimulation of neural networks that can be simulated in a computer...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226811/day-to-day-variability-in-hybrid-passive-brain-computer-interfaces-comparing-two-studies-assessing-cognitive-workload
#2
Samantha L Klosterman, Justin R Estepp, Jason W Monnin, James C Christensen, Samantha L Klosterman, Justin R Estepp, Jason W Monnin, James C Christensen, Jason W Monnin, Samantha L Klosterman, Justin R Estepp, James C Christensen
As hybrid, passive brain-computer interface systems become more advanced, it is important to grow our understanding of how to produce generalizable pattern classifiers of physiological data. One of the most difficult problems in applying machine learning algorithms to these data types is nonstationarity, which can evolve over the course of hours and days, and is more susceptible to changes resulting from complex cognitive function in comparison to simple, stimulus-based processes. This nonstationarity, referenced as day-to-day variability, results in the inability of many learning algorithms to generalize to new data...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220187/-emergency-medical-training-through-simulation-always-the-same-for-everyone
#3
A Schaumberg, T Schröder, M Sander
Simulation assumes a growing importance in the field of emergency medical education. Many rescue service schools work with simulators or even have their own simulation center. Classic resuscitation training in the classroom is increasingly being replaced by realistic case scenarios. But simulators themselves do not train! Using a simulator in emergency medical training does not necessarily mean achieving sustained learning success among the participants. Depending on the skills, abilities or competences being taught, there seems to be different requirements for simulation...
February 20, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28215244/driving-home-from-the-night-shift-a-bright-light-intervention-study
#4
Denise M Weisgerber, Maria Nikol, Ralph E Mistlberger
: Sleep deprivation (SD) impairs vigilance and increases the risk of driving accidents during the commute home after night work. Bright light (BL) can enhance alertness and cognitive performance. We examined the effects of BL (5600 lux) versus dim light (DL, 35 lux) at the end of a night awake on driving performance. METHODS: Subjects (N = 19, 22.8 ± 4 ya) completed three conditions, counterbalanced for order at >1 week intervals. The two overnight SD conditions began in the lab at usual bedtime...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28211003/an-easy-to-build-low-budget-point-of-care-ultrasound-simulator-from-linux-to-a-web-based-solution
#5
Domagoj Damjanovic, Ulrich Goebel, Benedikt Fischer, Martin Huth, Hartmut Breger, Hartmut Buerkle, Axel Schmutz
BACKGROUND: Hands-on training in point-of-care ultrasound (POC-US) should ideally comprise bedside teaching, as well as simulated clinical scenarios. High-fidelity phantoms and portable ultrasound simulation systems are commercially available, however, at considerable costs. This limits their suitability for medical schools. A Linux-based software for Emergency Department Ultrasound Simulation (edus2TM) was developed by Kulyk and Olszynski in 2011. Its feasibility for POC-US education has been well-documented, and shows good acceptance...
December 2017: Critical Ultrasound Journal
https://www.readbyqxmd.com/read/28207398/acoustic-classification-and-optimization-for-multi-modal-rendering-of-real-world-scenes
#6
Carl Schissler, Christian Loftin, Dinesh Manocha
We present a novel algorithm to generate virtual acoustic effects in captured 3D models of real-world scenes for multimodal augmented reality. We leverage recent advances in 3D scene reconstruction in order to automatically compute acoustic material properties. Our technique consists of a two-step procedure that first applies a convolutional neural network (CNN) to estimate the acoustic material properties, including frequency-dependent absorption coefficients, that are used for interactive sound propagation...
February 9, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28199109/the-nucleotide-selectivity-at-a-pre-insertion-checkpoint-of-t7-rna-polymerase-transcription-elongation
#7
Chao E, Baogen Duan, Jin Yu
Nucleotide selection is crucial for transcription fidelity control, in particular, for viral T7 RNA polymerase (RNAP) lack of proofreading activity. It has been recognized that multiple kinetic checkpoints exist prior to full nucleotide incorporation. In this work, we implemented intensive atomistic molecular dynamics (MD) simulations to quantify how strong the nucleotide selection is at the initial checkpoint of an elongation cycle of T7 RNAP. The incoming nucleotides bind into a pre-insertion site where a critical tyrosine residue locates nearby to assist the nucleotide selection...
February 15, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28196566/using-high-fidelity-simulation-scenarios-in-the-classroom-to-engage-learners
#8
Stephanie Turner, Leslie G Cole
It is well known that active teaching strategies improve student learning outcomes. By using simulation scenarios as a tool to teach systematic decision making in the classroom, faculty allow a large group of students to develop abstract thinking and gain experience in a setting that has traditionally delivered information in a linear format. This article will describe the process of using a high-fidelity simulation scenario as an unfolding case study to teach students how to manage and care for a patient.
February 1, 2017: Creative Nursing
https://www.readbyqxmd.com/read/28195967/procedural-learning-perspectives-of-pulmonary-fellows-and-practitioners
#9
Hans J Lee, Briana Coleman, Andrew D Lerner, David Feller-Kopman, Roy Semaan, Bernice Frimpong, Lonny Yarmus
BACKGROUND: Procedural learning requires both didactic knowledge and motor skills. Optimal teaching styles and techniques remain to be defined for pulmonary procedural learning. We investigated the preferences of learners at 2 different points in a pulmonary career; as pulmonary fellows and as clinical practitioners. METHODS: A perception survey was conducted among pulmonary fellows and practitioners from multiple institutions throughout the United States. Fellows and practitioners were immediately surveyed on procedural learning factors after completing a procedural learning course using low/high-fidelity and/or cadaver simulators...
February 10, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28195962/ebus-stat-subscore-analysis-to-predict-the-efficacy-and-assess-the-validity-of-virtual-reality-simulation-for-ebus-tbna-training-among-experienced-bronchoscopists
#10
Simone Scarlata, Patrizio Palermo, Piero Candoli, Ariela Tofani, Tommasangelo Petitti, Lorenzo Corbetta
BACKGROUND: Linear endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) represents a pivotal innovation in interventional pulmonology; determining the best approach to guarantee systematic and efficient training is expected to become a main issue in the forthcoming years. Virtual reality simulators have been proposed as potential EBUS-TBNA training instruments, to avoid unskilled beginners practicing directly in real-life settings. A validated and perfected simulation program could be used before allowing beginners to practice on patients...
February 10, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28188471/visualization-of-vascular-injuries-in-extremity-trauma
#11
Kwitae Chong, Chenfanfu Jiang, Daniel Ram, Anand Santhanam, Demetri Terzopoulos, Peyman Benharash, Erik Dutson, Joseph Teran, Jeff D Eldredge
A tandem of particle-based computational methods is adapted to simulate injury and hemorrhage in the human body. In order to ensure anatomical fidelity, a three-dimensional model of a targeted portion of the human body is reconstructed from a dense sequence of CT scans of an anonymized patient. Skin, bone and muscular tissue are distinguished in the imaging data and assigned with their respective material properties. An injury geometry is then generated by simulating the mechanics of a ballistic projectile passing through the anatomical model with the material point method...
February 11, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28187249/parallel-transmission-rf-pulse-design-with-strict-temperature-constraints
#12
Cem M Deniz, Giuseppe Carluccio, Christopher Collins
RF safety in parallel transmission (pTx) is generally ensured by imposing specific absorption rate (SAR) limits during pTx RF pulse design. There is increasing interest in using temperature to ensure safety in MRI. In this work, we present a local temperature correlation matrix formalism and apply it to impose strict constraints on maximum absolute temperature in pTx RF pulse design for head and hip regions. Electromagnetic field simulations were performed on the head and hip of virtual body models. Temperature correlation matrices were calculated for four different exposure durations ranging between 6 and 24 min using simulated fields and body-specific constants...
February 10, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28178963/immersive-high-fidelity-simulation-of-critically-ill-patients-to-study-cognitive-errors-a-pilot-study
#13
Shivesh Prakash, Shailesh Bihari, Penelope Need, Cyle Sprick, Lambert Schuwirth
BACKGROUND: The majority of human errors in healthcare originate from cognitive errors or biases. There is dearth of evidence around relative prevalence and significance of various cognitive errors amongst doctors in their first post-graduate year. This study was conducted with the objective of using high fidelity clinical simulation as a tool to study the relative occurrence of selected cognitive errors amongst doctors in their first post-graduate year. METHODS: Intern simulation sessions on acute clinical problems, conducted in year 2014, were reviewed by two independent assessors with expertise in critical care...
February 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28178332/a-hierarchical-estimator-development-for-estimation-of-tire-road-friction-coefficient
#14
Xudong Zhang, Dietmar Göhlich
The effect of vehicle active safety systems is subject to the friction force arising from the contact of tires and the road surface. Therefore, an adequate knowledge of the tire-road friction coefficient is of great importance to achieve a good performance of these control systems. This paper presents a tire-road friction coefficient estimation method for an advanced vehicle configuration, four-motorized-wheel electric vehicles, in which the longitudinal tire force is easily obtained. A hierarchical structure is adopted for the proposed estimation design...
2017: PloS One
https://www.readbyqxmd.com/read/28178060/modified-beef-tongue-model-for-fourth-degree-laceration-repair-simulation
#15
Jana D Illston, Alicia C Ballard, David R Ellington, Holly E Richter
BACKGROUND: An existing model for fourth-degree laceration repair uses beef tongue with plastic or vinyl tubing. This modified model substitutes beef tripe for the anal mucosa and chicken leg muscles for the anal sphincter muscle analogs to create a realistic model. METHOD: Tripe is tunneled through the body of the trimmed beef tongue and sutured like an ostomy to simulate the anal canal. The tongue is incised toward the tripe "anal canal." Chicken leg muscles are tunneled from the incision out to the cut edges of the beef tongue to create anal sphincter muscle analogs...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28176890/contextualizing-the-relevance-of-basic-sciences-small-group-simulation-with-debrief-for-first-and-second-year-medical-students-in-an-integrated-curriculum
#16
Samara B Ginzburg, Judith Brenner, Michael Cassara, Thomas Kwiatkowski, Joanne M Willey
AIM: There has been a call for increased integration of basic and clinical sciences during preclinical years of undergraduate medical education. Despite the recognition that clinical simulation is an effective pedagogical tool, little has been reported on its use to demonstrate the relevance of basic science principles to the practice of clinical medicine. We hypothesized that simulation with an integrated science and clinical debrief used with early learners would illustrate the importance of basic science principles in clinical diagnosis and management of patients...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28167584/modelling-high-reynolds-number-wall-turbulence-interactions-in-laboratory-experiments-using-large-scale-free-stream-turbulence
#17
Eda Dogan, R Jason Hearst, Bharathram Ganapathisubramani
A turbulent boundary layer subjected to free-stream turbulence is investigated in order to ascertain the scale interactions that dominate the near-wall region. The results are discussed in relation to a canonical high Reynolds number turbulent boundary layer because previous studies have reported considerable similarities between these two flows. Measurements were acquired simultaneously from four hot wires mounted to a rake which was traversed through the boundary layer. Particular focus is given to two main features of both canonical high Reynolds number boundary layers and boundary layers subjected to free-stream turbulence: (i) the footprint of the large scales in the logarithmic region on the near-wall small scales, specifically the modulating interaction between these scales, and (ii) the phase difference in amplitude modulation...
March 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28167582/scaling-and-interaction-of-self-similar-modes-in-models-of-high-reynolds-number-wall-turbulence
#18
A S Sharma, R Moarref, B J McKeon
Previous work has established the usefulness of the resolvent operator that maps the terms nonlinear in the turbulent fluctuations to the fluctuations themselves. Further work has described the self-similarity of the resolvent arising from that of the mean velocity profile. The orthogonal modes provided by the resolvent analysis describe the wall-normal coherence of the motions and inherit that self-similarity. In this contribution, we present the implications of this similarity for the nonlinear interaction between modes with different scales and wall-normal locations...
March 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28167580/structure-identification-in-pipe-flow-using-proper-orthogonal-decomposition
#19
Leo H O Hellström, Alexander J Smits
The energetic motions in direct numerical simulations of turbulent pipe flow at Reτ=685 are investigated using proper orthogonal decomposition. The procedure is extended such that a pressure component is identified in addition to the three-component velocity field for each mode. The pressure component of the modes is shown to align with the streamwise velocity component associated with the large-scale motions, where positive pressure coincides with positive streamwise velocity, and vice versa. The streamwise evolution of structures is then visualized using a conditional mode, which exhibit a strong similarity to the large-scale, low-momentum motions...
March 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28167578/low-dimensional-representation-of-near-wall-dynamics-in-shear-flows-with-implications-to-wall-models
#20
P J Schmid, T Sayadi
The dynamics of coherent structures near the wall of a turbulent boundary layer is investigated with the aim of a low-dimensional representation of its essential features. Based on a triple decomposition into mean, coherent and incoherent motion and a dynamic mode decomposition to recover statistical information about the incoherent part of the flow field, a driven linear system coupling first- and second-order moments of the coherent structures is derived and analysed. The transfer function for this system, evaluated for a wall-parallel plane, confirms a strong bias towards streamwise elongated structures, and is proposed as an 'impedance' boundary condition which replaces the bulk of the transport between the coherent velocity field and the coherent Reynolds stresses, thus acting as a wall model for large-eddy simulations (LES)...
March 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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