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Topical ivermectin

Atsushi Miyajima, Takashi Hirota, Mari Tashiro, Wataru Noguchi, Yayoi Kawano, Takehisa Hanawa, Akira Kigure, Taichi Anata, Yosuke Yamamoto, Nae Yuasa, Machi Koshino, Yumi Shiraishi, Kaoru Yuzawa, Keita Akagi, Takashi Yoshimasu, Kuniko Makigami, Masayo Komoda
As a novel administration method of ivermectin (IVM) for scabies treatment, we proposed a "whole-body bathing method (WBBM)". In this method, the patients would bathe themselves in a bathing fluid containing IVM at an effective concentration. Previously, we demonstrated that WBBM could deliver IVM to the skin but not to the plasma in rats. In the present study, to assess the clinical validity of the method an arm bathing examination (first trial) and a whole-body bathing examination (second trial) were conducted in healthy volunteers...
October 15, 2016: Journal of Dermatology
Charlotte Bernigaud, Fang Fang, Katja Fischer, Anne Lespine, Ludwig Serge Aho, Dominique Dreau, Andrew Kelly, Jean-François Sutra, Francis Moreau, Thomas Lilin, Françoise Botterel, Jacques Guillot, Olivier Chosidow
BACKGROUND: Scabies is one of the commonest dermatological conditions globally; however it is a largely underexplored and truly neglected infectious disease. Foremost, improvement in the management of this public health burden is imperative. Current treatments with topical agents and/or oral ivermectin (IVM) are insufficient and drug resistance is emerging. Moxidectin (MOX), with more advantageous pharmacological profiles may be a promising alternative. METHODOLOGY/PRINCIPAL FINDINGS: Using a porcine scabies model, 12 pigs were randomly assigned to receive orally either MOX (0...
October 2016: PLoS Neglected Tropical Diseases
Stefano Veraldi, Luisa Angileri, Bethsabeth Abigail Parducci, Gianluca Nazzaro
No abstract text is available yet for this article.
August 10, 2016: Journal of Dermatological Treatment
Dina M H El Akkad, Naglaa Saad M El-Gebaly, Hebat-Allah Salah A Yousof, Mousa A M Ismail
Head lice, Pediculus humanus capitis, infestation is an important public health problem in Egypt. Inadequate application of topical pediculicides and the increasing resistance to the commonly used pediculicides made the urgent need for the development of new agents able to induce irreversible changes in the exposed lice leading to their mortality. The aim of the present work is to evaluate pediculicidal efficacy of some natural products such as olive oil, tea tree oil, lemon juice, and ivermectin separately in comparison with tetramethrin-piperonyl butoxide (licid), as a standard pediculicide commonly used in Egypt...
August 2016: Korean Journal of Parasitology
Marta Mendieta Eckert, Nerea Landa Gundin
Rosacea is a highly prevalent, chronic inflammatory disease. The use of topical ivermectin cream has recently been described in the treatment of rosacea in three clinical trials. We report our experience in a series of 34 patients treated with topical ivermectin cream. The results are a reflection of the reality of clinical practice and the perception of patients of the treatment. We also evaluate the efficacy in cases of mild rosacea and erythematotelangiectatic rosacea which have not been studied in trials...
2016: Dermatology Online Journal
Ellen Koch, John Marshall Clark, Bernard Cohen, Terri L Meinking, William G Ryan, Audrey Stevenson, Robert Yetman, Kyong Sup Yoon
UNLABELLED: Head lice are a source of scalp irritation, social disruption, and loss of school time. Health care providers need authoritative information to help avoid the costs and risks of ineffective treatment. A review was completed to provide relevant information on infestation treatments available in the United States. Three major biomedical databases were searched from 1985, when current products were first available, to 2014, focusing on U.S. REPORTS: A total of 579 references remained after duplicates were removed...
September 2016: Pediatric Dermatology
Joseph F Fowler
Rosacea is a chronic skin disorder associated with flushing, erythema, dryness, burning and stinging, and inflammatory papules and pustules. New treatments available or in development target the inflammatory and erythematous components of the disease. These agents include the selective α2 receptor agonist brimonidine, the topical agents ivermectin cream 1% and azelaic acid foam 15%, and use of tetracyclinetype antibiotics, which affect the cathelicidin pathway. Semin Cutan Med Surg 35(supp6):S107-S109.
June 2016: Seminars in Cutaneous Medicine and Surgery
Xiaofei Shang, Yu Wang, Xuzheng Zhou, Xiao Guo, Shuwei Dong, Dongsheng Wang, Jiyu Zhang, Hu Pan, Yu Zhang, Xiaolou Miao
Oregano oil possesses marked antioxidant and antimicrobial activity and is widely applied in animal husbandry. In the present study, we aimed to investigate the acaricidal activities of oregano oil and its major component, carvacrol, thymol and p-cymene against Psoroptes cuniculi in vitro and in vivo. The results revealed that oregano oil exhibited significant acaricidal effects against P. cuniculi that were dose- and time-dependent response. In in vitro test, concentrations of 0.05% and 0.02% (v/v) killed all of the mites within 1h and 6h, respectively...
August 15, 2016: Veterinary Parasitology
Kashif Siddiqui, Linda Stein Gold, Japinder Gill
BACKGROUND: Rosacea is a common chronic skin condition that manifests as recurrent inflammatory lesions. Long-term treatment is required to control symptoms and disease progression, with topical treatments being the first-line choice. Ivermectin 1 % cream is a new once-daily (QD) topical treatment for the inflammatory lesions of rosacea, and it is important to compare the efficacy, safety, and tolerability of ivermectin with other currently available topical treatments. METHODS: A systematic literature review was performed from January 2011 to June 2015, with articles published prior to 2011 retrieved from a Cochrane review on rosacea...
2016: SpringerPlus
Martin Steinhoff, Marc Vocanson, Johannes J Voegel, Feriel Hacini-Rachinel, Gregor Schäfer
Rosacea is a common, chronic inflammatory skin disease that can present with a variety of signs and symptoms. The potentially simultaneous occurrence of different signs and symptoms is due to different underlying inflammatory pathways, emphasizing the need for complementary treatment approaches. Topical ivermectin cream (10 mg/g) and systemic, oral anti-inflammatory doxycycline (40 mg modified-release) are both approved for the treatment of papulopustular rosacea (PPR). Whether or not a combined therapeutic approach may be more beneficial than monotherapy for patients with PPR remains to be tested...
September 2016: Advances in Therapy
Jonette Keri
Acne and rosacea are common conditions seen every day by dermatologists. This review will discuss the most recent therapeutic options for patients with these conditions. Specifically, for acne, there will be a discussion of the use of isotretinoin at higher cumulative doses as well as a new formulation of isotretinoin, isotretinoin-lidose. Adult women with acne represent a growing population of patients who present for treatment of acne; the use of hormonal therapies as well as topical dapsone gel will be reviewed for these patients...
June 2016: Seminars in Cutaneous Medicine and Surgery
Thomas Dirschka, Lutz Schmitz, Ágota Bartha
We report the case of a German female patient presenting with papulopustular rosacea (PPR) with a high count of facial inflammatory lesions and severe erythema who had not responded well to treatment with traditional therapies for a decade. In this patient, a sequential therapy consisting of oral modified-release doxycycline 40 mg (initially as monotherapy, then in combination with topical metronidazole), followed by topical ivermectin 10 mg/g was both rapidly active and effective. Following reduction of the inflammation with modified-release doxycycline 40 mg upfront and the disease becoming moderate in severity, the dose of this agent could be reduced and combination therapy with metronidazole 7...
June 1, 2016: Journal of Drugs in Dermatology: JDD
Alain Taieb, Linda Stein Gold, Steven R Feldman, Viktor Dansk, Evelina Bertranou
BACKGROUND: Papulopustular rosacea is a chronic skin disease involving central facial erythema in combination with papules and pustules. Papulopustular rosacea is treated with topical, systemic, or a combination of topical and systemic therapies. Currently approved topical therapies include azelaic acid gel/cream/foam twice daily (BID) and metronidazole cream/gel/lotion BID. Ivermectin 1% cream once daily (QD) is a new topical agent for the treatment of papulopustular rosacea that has been approved for the management of inflammatory lesions of rosacea and offers an alternative to current treatments...
June 2016: Journal of Managed Care & Specialty Pharmacy
Andrea E Hasbach, Adam W Stern
A 9-year-old, intact female alpaca (Vicugna pacos) was presented for a second opinion with a 1-year history of nonpruritic, multifocal scaling and crusted cutaneous lesions, mainly involving skin on the face, axillae, and ventral abdomen. Clinical abnormalities were limited to the skin, and the alpaca was otherwise healthy. The initial veterinarian had examined the alpaca, found no evidence of ectoparasites with laboratory testing, and had tried several trial therapies including oral antibiotics, ivermectin, and topical use of betadine solution...
July 2016: Journal of Veterinary Diagnostic Investigation
Vicki O'Donnell, Sarah Morris, Jeanette Ward
No abstract text is available yet for this article.
April 28, 2016: New England Journal of Medicine
Antoine Mahé
No abstract text is available yet for this article.
April 28, 2016: New England Journal of Medicine
Andrew C Steer, Lucia Romani, John M Kaldor
No abstract text is available yet for this article.
April 28, 2016: New England Journal of Medicine
Leah A Cardwell, Hossein Alinia, Sara Moradi Tuchayi, Steven R Feldman
Rosacea is a chronic dermatological disorder with a variety of clinical manifestations localized largely to the central face. The unclear etiology of rosacea fosters therapeutic difficulty; however, subtle clinical improvement with pharmacologic treatments of various drug categories suggests a multifactorial etiology of the disease. Factors that may contribute to disease pathogenesis include immune abnormality, vascular abnormality, neurogenic dysregulation, presence of cutaneous microorganisms, UV damage, and skin barrier dysfunction...
2016: Clinical, Cosmetic and Investigational Dermatology
Byron L Blagburn, Robert G Arther, Allen R Dillon, Jamie M Butler, Joy V Bowles, Cristiano von Simson, Robert Zolynas
BACKGROUND: Heartworm disease in dogs can be severe and life threatening. Resistance to available heartworm preventives was considered among potential causes of increased reports of failed heartworm prevention in dogs. The objective of the present study was to compare the efficacy of four commercially available heartworm disease preventives against the JYD-34 strain of D. immitis. METHODS: Forty laboratory-reared dogs approximately 6 months old were used. Each dog was infected with fifty, third-stage heartworm larvae on study day (SD) -30...
2016: Parasites & Vectors
Talal A Abdel-Raheem, Eman M H Méabed, Ghada A Nasef, Wafaa Y Abdel Wahed, Rania M A Rohaim
The aim of this study is to evaluate four drug regimens for treatment of scabies as regard their efficacy, acceptability and cost effectiveness. Two hundred cases with ordinary scabies were randomized into four groups. First group received ivermectin 200 μg/kg body weight single oral dose, repeated after one week. The second received benzyl benzoate 20% cream. The third received permethrin 2.5%-5% lotion, whereas the fourth group received 5-10% sulfur ointment. Topical treatments were applied for five consecutive nights...
October 2016: Journal of Dermatological Treatment
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