keyword
MENU ▼
Read by QxMD icon Read
search

challenging

keyword
https://www.readbyqxmd.com/read/28092865/investigations-on-the-immunosuppressive-activity-of-derivatives-of-mycophenolic-acid-in-immature-dendritic-cells
#1
Dorota Iwaszkiewicz-Grzes, Grzegorz Cholewinski, Agata Kot-Wasik, Piotr Trzonkowski, Krystyna Dzierzbicka
The main activity of mycophenolic acid 1 (MPA) and its analogs is the inhibition of proliferation of T cells. Here, we hypothesized that MPA and its conjugates inhibits also the activity of antigen-presenting cells (APC) including dendritic cells (DCs). We tested the effect of novel amino acid derivatives of MPA and conjugates of MPA with acridines/acridones on DCs by flow cytometry, ELISA and MLR assay. Both acridines/acridone derivatives could inhibit the maturation of DC, as shown by the decreased expression of B7 family receptors...
January 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28092838/development-and-validation-of-the-stigma-scale-for-epilepsy-in-turkey
#2
Sevim Baybaş, Zerrin Yıldırım, Harika Ertem Özhan, Ayten Dirican, Ahmet Dirican
OBJECTIVE: Epilepsy is a chronic disease with an increased risk of stigma. The aim of this study was to investigate the efficacy of a scale developed by the authors to determine the level of stigma in Turkish patients with epilepsy and their relatives. METHODS: In this pilot study, two scales were developed, one consisting of 32 questions for the patients and one of 20 questions for the patients' relatives. Initially, a total of 30 patients with epilepsy and 30 relatives of the patients were included...
January 13, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28092832/sampling-conformational-space-of-intrinsically-disordered-proteins-in-explicit-solvent-comparison-between-well-tempered-ensemble-approach-and-solute-tempering-method
#3
Mengzhi Han, Ji Xu, Ying Ren
Intrinsically disordered proteins (IDPs) are a class of proteins that expected to be largely unstructured under physiological conditions. Due to their heterogeneous nature, experimental characterization of IDP is challenging. Temperature replica exchange molecular dynamics (T-REMD) is a widely used enhanced sampling method to probe structural characteristics of these proteins. However, its application has been hindered due to its tremendous computational cost, especially when simulating large systems in explicit solvent...
December 28, 2016: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28092792/curiosity-improves-coping-efficacy-and-reduces-suicidal-ideation-severity-among-military-veterans-at-risk-for-suicide
#4
Lauren M Denneson, Derek J Smolenski, Nigel E Bush, Steven K Dobscha
Curiosity, the tendency to engage in novel and challenging opportunities, may be an important source of resilience for those at risk for suicide. We hypothesized that curiosity would have a buffering effect against risk conferred by multiple sources of distress, whereby curiosity would be associated with reduced suicidal ideation and increased coping efficacy. As part of a larger intervention trial designed to improve coping skills and reduce suicidal ideation, 117 military veterans with suicidal ideation completed measures of curiosity and distress (perceived stress, depression, anxiety, and sleep disturbances) at baseline, and completed measures of suicidal ideation and coping efficacy (to stop negative thoughts, to enlist support from friends and family) at baseline and 3-, 6-, and 12-week follow up...
January 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28092784/inflammatory-myofibroblastic-tumor-involving-liver-gallbladder-pylorus-duodenum-a-rare-case-presentation
#5
Lakshmi Sinha, Arshad Hasan, Akhilesh Kumar Singh, Poonam Prasad Bhadani, Achyuta Nand Jha, Prashant Kumar Singh, Manoj Kumar
Inflammatory myofibroblastic tumors are rare benign tumors that can mimic malignancy of unknown aetiology. It has spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. Recently, the concept of this lesion being reactive has been challenged based on the clinical demonstration of recurrences and metastasis and cytogenetic evidence of acquired clonal chromosomal abnormalities. We hereby report a case of inflammatory myofibroblastic tumor involving liver, gallbladder pylorus and 1st part of duodenum...
January 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28092776/periosteum-tissue-engineering-in-an-orthotopic-in%C3%A2-vivo-platform
#6
J G Baldwin, F Wagner, L C Martine, B M Holzapfel, C Theodoropoulos, O Bas, F M Savi, C Werner, E M De-Juan-Pardo, D W Hutmacher
The periosteum plays a critical role in bone homeostasis and regeneration. It contains a vascular component that provides vital blood supply to the cortical bone and an osteogenic niche that acts as a source of bone-forming cells. Periosteal grafts have shown promise in the regeneration of critical size defects, however their limited availability restricts their widespread clinical application. Only a small number of tissue-engineered periosteum constructs (TEPCs) have been reported in the literature. A current challenge in the development of appropriate TEPCs is a lack of pre-clinical models in which they can reliably be evaluated...
November 20, 2016: Biomaterials
https://www.readbyqxmd.com/read/28092754/public-participation-gis-for-improving-wood-burning-emissions-from-residential-heating-and-urban-environmental-management
#7
Susana López-Aparicio, Matthias Vogt, Philipp Schneider, Maarit Kahila-Tani, Anna Broberg
A crowdsourcing study supported by a public participation GIS tool was designed and carried out in two Norwegian regions. The aim was to improve the knowledge about emissions from wood burning for residential heating in urban areas based on the collection of citizens' localized insights. We focus on three main issues: 1) type of dwelling and residential heating source; 2) wood consumption and type of wood appliances; and 3) citizens' perception of the urban environment. Our study shows the importance of wood burning for residential heating, and of the resulted particle emissions, in Norwegian urban areas...
January 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28092715/-family-a-challenge-for-the-future-of-our-earth
#8
Gilberto A Gamboa-Bernal
The Universal Declaration of Human Rights recognizes the family as the basic cell of society, highlighting its importance, the need to protect it, to promote it as a natural and fundamental group unit of society. To reflect on the effects that the actual culture is in the family is important from the situation as it is now presented, then move to raise the changes seen necessary to ensure their own future and that of their habitat that is Earth. To accomplish this first task some study results World Family Map 2015 is glossed...
September 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28092713/%C3%A2-the-anthropocene%C3%A2-ecosystem-management-and-environmental-virtue
#9
Ronald Sandler
*Portions of this article are drawn from: Sandler, R. Environmental Ethics: Theory in Practice, Oxford University Press, New York, in press. In this article I consider contrasting views on the implications of rapid, macroscale anthropogenic change for environmental ethics, particularly ecosystem management, species conservation, and environmental virtue. I begin by reviewing the Anthropocene debate, which has become a primary point of discourse on whether we ought to embrace a more interventionist stance regarding ecosystem management and species conservation...
September 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28092709/the-centrality-of-philosophical-anthropology-to-a-future-environmental-ethics
#10
Arran Gare
While environmental ethics has successfully established itself in philosophy, as presently conceived it is still largely irrelevant to grappling the global ecological crisis because, as Alasdair MacIntyre has argued, ethical philosophy itself is in grave disorder. MacIntyre's historically oriented recovery of virtue ethics is defended, but it is argued that even MacIntyre was too constrained by received assumptions to overcome this disorder. As he himself realized, his ideas need to be integrated and defended through philosophical anthropology...
September 2016: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/28092703/enantioselective-three-component-amination-of-enecarbamates-enables-the-synthesis-of-structurally-complex-small-molecules
#11
Audrey Dumoulin, Guillaume Bernadat, Géraldine Masson
The control of asymmetric synthesis tools represents a major challenge, especially when it comes to the synthesis of bioactive molecules. In this context, the asymmetric synthesis of 1,2-diamines through amination of enecarbamates has appeared to us as a highly efficient and tunable approach. Indeed, reactivity of the latter species could be exploited to realize a double functionalization via an electrophilic amination followed by nucleophilic trapping. Herein, we describe a chiral phosphoric acid-catalyzed electrophilic amination of enecarbamates with dibenzylazodicarboxylate and oxygenated or thiol-containing nucleophiles affording stable precursors of α-hydrazinoimines in high yields and with almost complete enantioselectivities (up to >99%)...
January 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28092689/three-dimensional-imaging-of-dislocation-dynamics-during-the-hydriding-phase-transformation
#12
A Ulvestad, M J Welland, W Cha, Y Liu, J W Kim, R Harder, E Maxey, J N Clark, M J Highland, H You, P Zapol, S O Hruszkewycz, G B Stephenson
Crystallographic imperfections significantly alter material properties and their response to external stimuli, including solute-induced phase transformations. Despite recent progress in imaging defects using electron and X-ray techniques, in situ three-dimensional imaging of defect dynamics remains challenging. Here, we use Bragg coherent diffractive imaging to image defects during the hydriding phase transformation of palladium nanocrystals. During constant-pressure experiments we observe that the phase transformation begins after dislocation nucleation close to the phase boundary in particles larger than 300 nm...
January 16, 2017: Nature Materials
https://www.readbyqxmd.com/read/28092658/mutation-effects-predicted-from-sequence-co-variation
#13
Thomas A Hopf, John B Ingraham, Frank J Poelwijk, Charlotta P I Schärfe, Michael Springer, Chris Sander, Debora S Marks
Many high-throughput experimental technologies have been developed to assess the effects of large numbers of mutations (variation) on phenotypes. However, designing functional assays for these methods is challenging, and systematic testing of all combinations is impossible, so robust methods to predict the effects of genetic variation are needed. Most prediction methods exploit evolutionary sequence conservation but do not consider the interdependencies of residues or bases. We present EVmutation, an unsupervised statistical method for predicting the effects of mutations that explicitly captures residue dependencies between positions...
January 16, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28092578/experienced-gray-wolf-optimization-through-reinforcement-learning-and-neural-networks
#14
E Emary, Hossam M Zawbaa, Crina Grosan
In this paper, a variant of gray wolf optimization (GWO) that uses reinforcement learning principles combined with neural networks to enhance the performance is proposed. The aim is to overcome, by reinforced learning, the common challenge of setting the right parameters for the algorithm. In GWO, a single parameter is used to control the exploration/exploitation rate, which influences the performance of the algorithm. Rather than using a global way to change this parameter for all the agents, we use reinforcement learning to set it on an individual basis...
January 10, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28092574/dynamics-in-epistasis-analysis
#15
Aseel Awdeh, Hilary Phenix, Mads Kaern, Theodore Perkins
Finding regulatory relationships between genes, including the direction and nature of influence between them, is a fundamental challenge in the field of molecular genetics. One classical approach to this problem is epistasis analysis. Broadly speaking, epistasis analysis infers the regulatory relationships between a pair of genes in a genetic pathway by considering the patterns of change in an observable trait resulting from single and double deletion of genes. While classical epistasis analysis has yielded deep insights on numerous genetic pathways, it is not without limitations...
January 16, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28092573/environment-sensitivity-based-cooperative-co-evolutionary-algorithms-for-dynamic-multi-objective-optimization
#16
Biao Xu, Yong Zhang, Dunwei Gong, Yinan Guo, Miao Rong
Dynamic multi-objective optimization problems (DMOPs) not only involve multiple conflicting objectives, but these objectives may also vary with time, raising a challenge for researchers to solve them. This paper presents a cooperative co-evolutionary strategy based on environment sensitivities for solving DMOPs. In this strategy, a new method that groups decision variables is first proposed, in which all the decision variables are partitioned into two subcomponents according to their interrelation with environment...
January 16, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28092565/a-passive-eeg-bci-for-single-trial-detection-of-changes-in-mental-state
#17
Andrew Myrden, Tom Chau
Traditional brain-computer interfaces often exhibit unstable performance over time. It has recently been proposed that passive brain-computer interfaces may provide a way to complement and stabilize these traditional systems. In this study, we investigated the feasibility of a passive brain-computer interface that uses electroencephalography to monitor changes in mental state on a single-trial basis. We recorded cortical activity from 15 locations while 11 able-bodied adults completed a series of challenging mental tasks...
January 9, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28092556/study-of-saliency-in-objective-video-quality-assessment
#18
Wei Zhang, Hantao Liu
Reliably predicting video quality as perceived by humans remains challenging and is of high practical relevance. A significant research trend is to investigate visual saliency and its implications for video quality assessment. Fundamental problems regarding how to acquire reliable eye-tracking data for the purpose of video quality research and how saliency should be incorporated in objective video quality metrics (VQMs) are largely unsolved. In this paper, we propose a refined methodology for reliably collecting eye-tracking data, which essentially eliminates bias induced by each subject having to view multiple variations of the same scene in a conventional experiment...
January 10, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28092555/progressive-shape-distribution-encoder-for-3d-shape-retrieval
#19
Jin Xie, Fan Zhu, Guoxian Dai, Ling Shao, Yi Fang
Since there are complex geometric variations with 3D shapes, extracting efficient 3D shape features is one of the most challenging tasks in shape matching and retrieval. In this paper, we propose a deep shape descriptor by learning shape distributions at different diffusion time via a progressive shape-distribution-encoder (PSDE). First, we develop a shape distribution representation with the kernel density estimator to characterize the intrinsic geometry structures of 3D shapes. Then, we propose to learn a deep shape feature through an unsupervised PSDE...
January 10, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28092553/deep-aesthetic-quality-assessment-with-semantic-information
#20
Yueying Kao, Ran He, Kaiqi Huang
Human beings often assess the aesthetic quality of an image coupled with the identification of the image's semantic content. This paper addresses the correlation issue between automatic aesthetic quality assessment and semantic recognition. We cast the assessment problem as the main task among a multitask deep model, and argue that semantic recognition task offers the key to address this problem. Based on convolutional neural networks, we employ a single and simple multi-task framework to efficiently utilize the supervision of aesthetic and semantic labels...
January 11, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
keyword
keyword
46671
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"