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https://www.readbyqxmd.com/read/29352757/refractory-heartburn-a-challenging-problem-in-clinical-practice
#1
REVIEW
Gerson Domingues, Joaquim Prado P Moraes-Filho, Ronnie Fass
Gastroesophageal reflux disease (GERD) is a condition which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Heartburn and regurgitation are the typical symptoms of GERD. The treatment of GERD encompasses lifestyle modifications, pharmacological, endoscopic, and surgical therapy. The majority of the patients respond to 4-8 weeks of proton-pump inhibitors therapy, but 20-42% will demonstrate partial or complete lack of response to treatment. While these patients have been considered as having refractory heartburn, a subset of them does not have GERD or have not been adequately treated...
January 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29352754/providing-ethical-healthcare-in-resource-poor-environments
#2
Kenneth V Iserson
The ethics of providing health care in resource-poor environments is a complex topic. It implies two related questions: What can we do with the resources on hand? Of all the things we can do, which ones should we do? "Resource-poor" (i.e., resource-challenged, resource-constrained) environments are situations in which clinicians, organizations, or healthcare systems have the knowledge and skills, but not the means, to carry out highly effective and beneficial interventions. Determinants of a population's health often rely less on disease and injury management than on recognizing and meeting their basic needs...
January 19, 2018: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/29352751/surgical-management-for-a-huge-presacral-teratoma-and-a-meningocele-in-an-adult-with-currarino-triad-a-case-report
#3
Shigenobu Emoto, Manabu Kaneko, Koji Murono, Kazuhito Sasaki, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Keisuke Hata, Kazushige Kawai, Hideaki Imai, Nobuhito Saito, Hiroshi Kobayashi, Sakae Tanaka, Masako Ikemura, Tetsuo Ushiku, Hiroaki Nozawa
BACKGROUND: The Currarino triad is a rare hereditary syndrome comprising anorectal malformation, sacral bony defect, and presacral mass. Most of the patients are diagnosed during infancy. CASE PRESENTATION: A 44-year-old man was diagnosed with Currarino triad, with a huge presacral teratoma and meningocele. One-stage surgery via posterior approach was successful. CONCLUSIONS: Treatment of the presacral mass in the Currarino triad, diagnosed in adulthood, is challenging...
January 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29352730/teaching-of-anatomical-sciences-a-blended-learning-approach
#4
REVIEW
Mohammed K Khalil, Eiman M Abdel Meguid, Ihsan E Elkhider
Blended learning is the integration of different learning approaches, new technologies and activities that combine traditional face-to-face teaching methods with authentic online methodologies. Although advances in educational technology have helped to expand the selection of different pedagogies, the teaching of anatomical sciences has been challenged by implementation difficulties and other limitations. These challenges are reported to include lack of time, costs, and lack of qualified teachers. Easy access to online information and advances in technology make it possible to resolve these limitations by adopting blended learning approaches...
January 20, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29352706/environmental-conditions-in-health-care-facilities-in-low-and-middle-income-countries-coverage-and-inequalities
#5
Ryan Cronk, Jamie Bartram
Safe environmental conditions and the availability of standard precaution items are important to prevent and treat infection in health care facilities (HCFs) and to achieve Sustainable Development Goal (SDG) targets for health and water, sanitation, and hygiene. Baseline coverage estimates for HCFs have yet to be formed for the SDGs; and there is little evidence describing inequalities in coverage. To address this, we produced the first coverage estimates of environmental conditions and standard precaution items in HCFs in low- and middle-income countries (LMICs); and explored factors associated with low coverage...
January 11, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29352648/learning-diversity-in-nurse-education-and-practice-current-challenges-contemporary-perspectives-and-innovative-solutions
#6
EDITORIAL
Jane Wray, Kerry Pace
No abstract text is available yet for this article.
December 29, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29352640/recent-advancements-in-bioremediation-of-dye-current-status-and-challenges
#7
REVIEW
Kumar Vikrant, Balendu Shekhar Giri, Nadeem Raza, Kangkan Roy, Ki-Hyun Kim, Birendra Nath Rai, Ram Sharan Singh
The rampant industrialization and unchecked growth of modern textile production facilities coupled with the lack of proper treatment facilities have proliferated the discharge of effluents enriched with toxic, baleful, and carcinogenic pollutants including dyes, heavy metals, volatile organic compounds, odorants, and other hazardous materials. Therefore, the development of cost-effective and efficient control measures against such pollution is imperative to safeguard ecosystems and natural resources. In this regard, recent advances in biotechnology and microbiology have propelled bioremediation as a prospective alternative to traditional treatment methods...
January 8, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29352622/anaesthesia-for-caesarean-section-in-a-patient-with-parkinson-s-disease
#8
V D Ward
Parkinson's disease is prevalent worldwide but mainly affects the elderly and is rarely seen in women of child-bearing age. The clinical signs and symptoms, the physiological changes of pregnancy, and drug interactions, pose unique challenges for the anaesthetic management of patients with Parkinson's disease who present for delivery. A 36-year-old primigravid woman at 36 weeks' gestation, with Parkinson's disease, presented for pre-anaesthesia assessment prior to elective caesarean section. Her Parkinson's disease had been diagnosed four years previously and was treated with Sinemet (levodopa/carbidopa) and pramipexole...
November 21, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29352580/individual-student-characteristics-and-attainment-in-pre-registration-physiotherapy-a-retrospective-multi-site-cohort-study
#9
Meriel Norris, John A Hammond, Annabel Williams, Robert Grant, Sandra Naylor, Catherine Rozario
INTRODUCTION: Worldwide there is a desire to diversify the physiotherapy workforce. However, limited research indicates that some student characteristics linked to under-representation in pre registration physiotherapy education have lower attainment and greater attrition. This study explored the relationship between individual characteristics and success of students in pre registration physiotherapy education within South East England. DESIGN: A retrospective multi site cohort study including pre registration physiotherapy programmes in the South East of England...
October 31, 2017: Physiotherapy
https://www.readbyqxmd.com/read/29352579/informed-consent-in-physiotherapy-practice-it-is-not-what-is-said-but-how-it-is-said
#10
G Copnell
This paper discusses the concept of informed consent in the context of contemporary biomedical ethics. A change in UK law regarding what information should be provided to patients has brought to the fore the role of physiotherapists in the process of gaining informed consent. It is important that physiotherapists are aware of how this change in the law will affect their practice. For an individual to consent, they need to have both the capacity and freedom to exercise rational thought. These concepts are challenged in contemporary biomedical ethics...
August 7, 2017: Physiotherapy
https://www.readbyqxmd.com/read/29352553/why-measuring-quality-of-mental-health-care-is-still-an-unmet-challenge-and-how-to-meet-it
#11
Mirella Ruggeri
No abstract text is available yet for this article.
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29352538/the-promise-and-challenges-of-drug-repurposing-in-psychiatry
#12
EDITORIAL
Maurizio Fava
No abstract text is available yet for this article.
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29352521/microdenervation-of-the-spermatic-cord-for-post-vasectomy-pain-syndrome
#13
Wei Phin Tan, Peter N Tsambarlis, Laurence A Levine
INTRODUCTION: Post Vasectomy Pain Syndrome (PVPS) is an uncommon urologic problem that remains a challenge to manage. We aim to evaluate the outcomes of patients who underwent microdenervation of the spermatic cord (MDSC) for PVPS at our institution. METHODS: A retrospective study of all patients who underwent MDSC for PVPS by a single surgeon from March 2002 to October 2016 was performed. Pain was documented using the numerical rating scale (NRS). Spermatic cord block (SCB) was performed on all patients and success was defined as NRS ≤1 for >4 hours...
January 20, 2018: BJU International
https://www.readbyqxmd.com/read/29352516/successful-hematopoietic-cell-transplantation-following-cardiac-transplantation-in-two-pediatric-patients
#14
Rachel Phelan, Angela R Smith, Paul J Orchard, Rebecca K Ameduri
We report two patients who underwent cardiac transplantation at a young age and subsequently required a HCT for varied indications. Despite the challenges associated with HCT following cardiac transplant, including need for altered immunosuppression, toxicities related to chemotherapy exposure, and infection risks, both patients are currently alive and well. There is a paucity of such successful cases documented in the literature, and these cases highlight the critical importance of an experienced, multidisciplinary team when caring for this patient population...
January 19, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29352494/the-effects-of-late-gestation-nutrient-restriction-of-dams-on-beef-heifer-intake-metabolites-and-hormones-during-an-ad-libitum-feeding-trial
#15
J E Tipton, R E Ricks, C T LeMaster, N M Long
This study's objective was to determine if nutrient restriction during late gestation affected beef heifer feed intake, body weight (BW) gain and endocrine regulation during a 10-week feeding trial. During the last 100 days of gestation, control (CON) dams were fed to increase body condition score (BCS). Whereas, nutrient-restricted dams (NR) and NR dams protein supplemented 3 days/week (NRS) were fed to decrease BCS by 1.2. After parturition, all cow-calf pairs were moved to a common pasture and fed in excess of requirements until weaning...
January 19, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29352468/developmental-plasticity-of-gabaergic-neurotransmission-to-brainstem-motoneurons
#16
Lila Buls Wollman, Richard B Levine, Ralph F Fregosi
Nicotinic acetylcholine receptor (nAChR) signalling regulates neuronal differentiation and synaptogenesis. Here we test the hypothesis that developmental nicotine exposure (DNE) disrupts the development of GABAergic synaptic transmission to hypoglossal motoneurons (XIIMNs). GABAergic spontaneous and miniature inhibitory postsynaptic currents (sIPSC/mIPSC) were recorded from XIIMNs in brainstem slices from control and DNE rat pups of either sex, 1-5 days old, at baseline and following acute stimulation of nAChRs with nicotine...
January 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29352449/continuous-exposure-to-microplastics-does-not-cause-physiological-effects-in-the-cultivated-mussel-perna-perna
#17
Marina F M Santana, Fabiana T Moreira, Camilo D S Pereira, Denis M S Abessa, Alexander Turra
The environmental impact of microplastics is a challenging theme, especially under realistic experimental conditions. We investigated physiological responses to 0.1-1.0 μm PVC particles intake by the mussel Perna perna after a relative long-term exposure (90 days) at a less extreme concentration compared with previous studies (0.125 g/L). Microplastic intake was inferred by the presence of PVC in the feces of mussels, and physiological damages were assessed through ingestion rate, assimilation efficiency, growth rate, cellular and molecular biomarkers (lysosomal integrity, lipid peroxidation, and DNA damage), and condition index...
January 19, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29352421/predictors-of-insulin-initiation-in-patients-with-type-2-diabetes-an-analysis-of-the-look-ahead-randomized-trial
#18
Scott J Pilla, Hsin-Chieh Yeh, Stephen P Juraschek, Jeanne M Clark, Nisa M Maruthur
BACKGROUND: The decision to initiate insulin in patients with type 2 diabetes is a challenging escalation of care that requires an individualized approach. However, the sociodemographic and clinical factors affecting insulin initiation are not well understood. OBJECTIVE: We sought to identify patient factors that were independent predictors of insulin initiation among participants in the Look AHEAD (Action for Health in Diabetes) clinical trial. DESIGN: Retrospective analysis of a randomized clinical trial...
January 19, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29352416/point-of-care-ultrasound-in-pediatric-anesthesiology-and-critical-care-medicine
#19
REVIEW
Erik Su, Nicholas Dalesio, Aliaksei Pustavoitau
Ultrasound has increasingly become a clinical asset in the hands of the anesthesiologist and intensivist who cares for children. Though many applications for ultrasound parallel adult modalities, children as always are not simply small adults and benefit from the application of ultrasound to their management in various ways. Body composition and size are important factors that affect ultrasound performance in the child, as are the pathologies that may uniquely afflict children and aspects of procedures unique to this patient population...
January 19, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29352393/eco-friendly-pheromone-dispensers-a-green-route-to-manage-the-european-grapevine-moth
#20
Andrea Lucchi, Edith Ladurner, Andrea Iodice, Francesco Savino, Renato Ricciardi, Francesca Cosci, Giuseppe Conte, Giovanni Benelli
The development of environmentally sustainable control strategies to fight insect pests is a key challenge nowadays. Pheromone-mediated mating disruption (MD) is based on the release of synthetic sex attractants into a crop, interfering with mate finding of a given pest species. However, a limited number of research items have been published on the optimization of MD strategies against the European grapevine moth, Lobesia botrana, as well as on the use of biodegradable dispensers to reduce waste production in vineyards, despite the high economic importance of this pest...
January 19, 2018: Environmental Science and Pollution Research International
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