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Diabetic Vitrectomy

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https://www.readbyqxmd.com/read/28435237/evaluation-of-ex-press-glaucoma-implant-in-elderly-diabetic-patients-after-23g-vitrectomy
#1
Anita Lyssek-Boroń, Adam Wylęgała, Dariusz Dobrowolski, Ewelina Kowalczyk, Katarzyna Polanowska, Edward Wylęgała
PURPOSE: The most frequent qualifications for pars plana vitrectomy (PPV) in diabetic patients include recurrent hemorrhage into the vitreous body chamber and vitreoretinal proliferation, also with traction retinal detachment. The aim of this study was to evaluate the effectiveness of EX-PRESS implant for the treatment of secondary glaucoma in elderly diabetic patients following PPV 23G with silicon oil or SF6 gas endotamponade. MATERIALS AND METHODS: This retrospective analysis comprised 18 patients (19 eyes)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28427074/enzymatic-vitreolysis-for-vitreomacular-traction-in-diabetic-retinopathy
#2
Stanislao Rizzo, Daniela Bacherini
Vitreomacular traction (VMT) is one of many possible factors involved in the etiology of diabetic macular edema (DME). Pharmacologic vitreoretinal separation is a potential alternative to vitrectomy for VMT in diabetic retinopathy. Small case series have been published on the use of enzymatic vitreolysis in tractional DME, and demonstrate that the enzymatic release of the posterior vitreous cortex is more likely following the injection of plasmin enzyme. Further prospective and randomized clinical trials are necessary to evaluate the clinical relevance of ocriplasmin for vitreomacular traction in diabetic retinopathy, and additional studies are needed to determine more accurately which patients might benefit most from this treatment and how often and at what concentration ocriplasmin should be administered...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28427072/anti-vascular-endothelial-growth-factor-injections-the-new-standard-of-care-in-proliferative-diabetic-retinopathy
#3
Xintong Li, Marco A Zarbin, Neelakshi Bhagat
For decades, panretinal photocoagulation (PRP) has been the standard of care for the treatment of proliferative diabetic retinopathy (PDR). The relatively recent advent of anti-vascular endothelial growth factor (VEGF) formulations for intravitreal injection has provided a fresh perspective on PDR treatment, especially in eyes with concurrent diabetic macular edema (DME). The anti-VEGF agent ranibizumab has demonstrated a potentially protective effect on eyes with DME in terms of progression to PDR in the RIDE/RISE trials, as has aflibercept in the VIVID/VISTA trials...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28426628/ocular-hypertension-and-glaucoma-following-vitrectomy-a-systematic-review
#4
Alba Miele, Andrea Govetto, Carlo Fumagalli, Simone Donati, Ilaria Biagini, Claudio Azzolini, Stanislao Rizzo, Gianni Virgili
PURPOSE: Pars plana vitrectomy has been reported to increase the risk of ocular hypertension and open-angle glaucoma. The authors conducted a systematic review of randomized and nonrandomized studies to compare the incidence of open-angle glaucoma and ocular hypertension in vitrectomized versus nonvitrectomized eyes. METHODS: A literature search was performed using MEDLINE and EMBASE until August 2016. Data on ocular hypertension and open-angle glaucoma incidence and mean intraocular pressure after at least 1 year were pooled using random-effects metaanalysis models...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28421343/antiplatelets-and-anticoagulants-in-vitreoretinal-surgery-with-a-special-emphasis-on-novel-anticoagulants-a-national-survey-and-review
#5
REVIEW
Rupa Patel, Stephen Charles, Assad Jalil
PURPOSE: To survey current practice and opinion regarding the cessation of antiplatelet and anticoagulant agents prior to vitreoretinal surgery, with special emphasis on novel anticoagulants, and to provide an overview of current literature. METHODS: An online survey was sent to 167 members of the British and Eire Association of Vitreoretinal Surgeons (BEAVRS). A literature search and analysis was conducted on studies that reviewed the bleeding risk of antiplatelet and anticoagulant agents...
April 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28413403/two-cases-of-proliferative-diabetic-retinopathy-with-marked-sheathing-of-the-retinal-arteries-following-vitrectomy
#6
Yuko Nishikawa, Seita Morishita, Kimitoshi Nakamura, Masanori Fukumoto, Hiroyuki Suzuki, Kensuke Tajiri, Takaki Sato, Takatoshi Kobayashi, Teruyo Kida, Hidehiro Oku, Tsunehiko Ikeda
PURPOSE: The aim of this paper was to report 2 patients (3 eyes) with proliferative diabetic retinopathy (PDR) who showed marked sheathing of the retinal arterioles that was ultimately attributed to calcification following vitrectomy. CASES: Case 1 involved a 65-year-old female with PDR who underwent bilateral vitrectomy for traction retinal detachment. Postoperatively, bilateral retinal redetachment (reRD) was observed. Sheathing of the retinal arterioles was observed at the same time, yet was not apparent preoperatively...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28409025/the-impact-of-the-menstrual-cycle-on-perioperative-bleeding-in-vitreoretinal-surgery
#7
Zhong Lin, Nived Moonasar, Rong Han Wu, Robin R Seemongal-Dass
Purpose. To investigate the effect of menstrual cycle on perioperative bleeding of primary vitreoretinal surgery. Methods. Data on female patients who had vitrectomy surgery was retrospectively collected. Exclusion criteria were history of trauma, vitreous hemorrhage, previous vitreoretinal surgery, diabetic retinopathy, endophthalmitis, acute retinal necrosis, single vitreous opacity, and use of antiplatelet agents. Perioperative bleeding was defined as hemorrhage in the iris, vitreous, choroidal, retina, or subretina during surgery or up to one day postoperatively...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28402943/expression-of-wild-type-p53-induced-phosphatase-1-in-diabetic-epiretinal-membranes
#8
Jiping Xu, Haibin Zhong, Ling Cui, Qianqian Lan, Lifei Chen, Wenjing He, Yu Wu, Li Jiang, Hui Huang, Xin Zhao, Li Li, Siming Zeng, Min Li, Fan Xu
OBJECTIVE: The aims of the present study were to investigate the expression and distribution of Wild-type p53-induced phosphatase 1 (Wip1) in diabetic patients with proliferative diabetic retinopathy (PDR) with epiretinal membranes (ERMs) meanwhile analyze the colocalization of Wip1 and nuclear factor kappa-B (NF-κB) p65 in ERMs. METHODS: ERMs samples were collected from patients with PDR (PDR group) or non-diabetic patients with idiopathic epiretinal membranes (iERMs) (control group) during pars plana vitrectomy...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28367178/outcomes-of-transconjunctival-sutureless-27-gauge-micro-incision-vitrectomy-surgery-in-diabetic-vitreous-haemorrhage
#9
Bashiran Shahzadi, Syed Fawad Rizwi, Faisal Murtaza Qureshi, Kanwal Latif, Syed Asaad Mahmood
OBJECTIVE: To evaluate the visual outcomes of 27-gauge transconjunctival sutureless vitrectomy surgery and its complications in patients with diabetic vitreous hemorrhage. METHODS: A quasi-experimental study was conducted where eighty seven eyes of 87 uncontrolled type II diabetes mellitus patients presenting with diabetic vitreous hemorrhage were selected to undergo 27-gauge transconjunctival sutureless micro-incision vitrectomy surgery. Main outcome measured was best corrected visual acuity (BCVA)...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28365411/effects-of-intensive-glucose-control-on-microvascular-outcomes-in-patients-with-type-2-diabetes-a-meta-analysis-of-individual-participant-data-from-randomised-controlled-trials
#10
Sophia Zoungas, Hisatomi Arima, Hertzel C Gerstein, Rury R Holman, Mark Woodward, Peter Reaven, Rodney A Hayward, Timothy Craven, Ruth L Coleman, John Chalmers
BACKGROUND: Intensive glucose control is understood to prevent complications in adults with type 2 diabetes. We aimed to more precisely estimate the effects of more intensive glucose control, compared with less intensive glucose control, on the risk of microvascular events. METHODS: In this meta-analysis, we obtained de-identified individual participant data from large-scale randomised controlled trials assessing the effects of more intensive glucose control versus less intensive glucose control in adults with type 2 diabetes, with at least 1000 patient-years of follow-up in each treatment group and a minimum of 2 years average follow-up on randomised treatment...
March 29, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28358744/short-term-outcomes-of-hybrid-23-25-and-27-gauge-vitrectomy-for-complex-diabetic-tractional-retinal-detachment-repair
#11
M Ali Khan, Wasim A Samara, Jason Hsu, Sunir Garg
PURPOSE: To describe the short-term outcomes of complex diabetic retinal detachment repair using hybrid 23-gauge or 25-gauge vitrectomy instruments with a 27-gauge vitrectomy system. METHODS: Retrospective, interventional, consecutive case series. Ten eyes of 10 patients undergoing hybrid pars plana vitrectomy for diabetic tractional retinal detachment were reviewed. RESULTS: Combined use of 25-gauge and 27-gauge instrumentation was used in 8 of 10 eyes and combined use of 23-gauge and 27-gauge instrumentation in 2 of 10 eyes...
March 29, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28351053/macular-edema-rationale-for-therapy
#12
Thomas J Wolfensberger
Macular edema represents the end-stage of multiple pathophysiological pathways in a multitude of ocular vascular, inflammatory, and other diseases. The rationale for clinical treatment of macular edema is based on the understanding and the inhibition of these pathophysiological mechanisms. When macular edema is caused by a generalized health problem such as diabetes, high blood pressure, or generalized inflammatory conditions, treatment of these generalized diseases can in many cases cure macular edema directly...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28348188/influencing-factors-on-compliance-of-timely-visits-among-patients-with-proliferative-diabetic-retinopathy-in-southern-china-a-qualitative-study
#13
Fang Duan, Yuhong Liu, Xiang Chen, Nathan Congdon, Jian Zhang, Qianyun Chen, Lingling Chen, Xi Chen, Xiulan Zhang, Chengpu Yu, Yizhi Liu
OBJECTIVE: To identify the reasons for low adherence among patients with diabetic retinopathy (DR) in southern China using a qualitative method. METHODS: Exploratory indepth interviews were conducted in 27 diabetic patients with proliferative diabetic retinopathy who required vitrectomy surgery at Zhongshan Ophthalmic Centre, Sun Yat-sen University, from March to August 2015. Qualitative data analysis and research software (ATLAS.ti7) was used for data processing and analysis...
March 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28337065/acute-bacterial-endophthalmitis-following-intravitreal-dexamethasone-implant-a-case-report-and-review-of-literature
#14
Neha Goel
Endophthalmitis following intravitreal dexamethasone (DEX) implant has been rarely reported. This report describes the case of a 70-year-old male who underwent intravitreal DEX implant injection under aseptic conditions, for diabetic macular edema. He developed a clinical picture suggestive of endophthalmitis within 2 weeks of the injection, and vitreous culture grew coagulase negative Staphylococcus. He was treated with intravitreal antibiotics followed by pars plana vitrectomy and removal of the implant...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28333877/predicting-visual-outcomes-of-second-eye-vitrectomy-for-proliferative-diabetic-retinopathy
#15
Marko Sulak, Mojca Urbancic, Mojca Globocnik Petrovic
PURPOSE: To investigate predictive factors for visual outcome in the second operated eye of patients undergoing bilateral vitrectomy for proliferative diabetic retinopathy. METHODS: Clinical records of 55 patients undergoing bilateral vitrectomy for proliferative diabetic retinopathy at the University Eye Hospital Ljubljana between January 2009 and December 2014 were examined retrospectively. Statistical analysis was performed to identify variables associated with good visual outcomes...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28299499/evaluation-of-vitreous-levels-of-advanced-glycation-end-products-and-angiogenic-factors-as-biomarkers-for-severity-of-diabetic-retinopathy
#16
Makiko Katagiri, Jun Shoji, Noriko Inada, Satoshi Kato, Shigehiko Kitano, Yasuko Uchigata
BACKGROUND/AIMS: Glyceraldehyde-derived advanced glycation end products (glycer-AGE; also called Toxic-AGE [TAGE]) play a crucial role in the pathogenesis of diabetic angiopathy. However, the relationships between vitreous glycer-AGE levels and diabetic retinopathy (DR) severity, and between glycer-AGE levels and the levels of other angiogenic factors remain unknown. We investigated the correlation between levels of vitreous biomarkers, including glycer-AGE and angiogenic factors (vascular endothelial growth factor [VEGF], interleukin [IL]-8, leptin, placental growth factor [PlGF], endoglin, and fibroblast growth factor [FGF]-2) in patients with DR, using three DR staging groups...
March 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28294558/trends-in-diabetic-retinopathy-and-related-medical-practices-among-type-2-diabetes-results-from-the-national-insurance-service-survey-2006-2013
#17
REVIEW
Su Jeong Song, Kyungdo Han, Kyung Seek Choi, Seung-Hyun Ko, Eun-Jung Rhee, Cheol-Young Park, Joong-Yeol Park, Kyung-Soo Ko, Ki-Up Lee
AIMS/INTRODUCTION: This study aimed to analyze the temporal changes in the prevalence, screening rate, visual impairments, and treatment patterns of diabetic retinopathy in the Korean population over 8 years. MATERIALS AND METHODS: This was a retrospective population-based study of Korean national health insurance beneficiaries aged 30 years or older with type 2 diabetes, obtained from the Korean National Health Insurance Claims database from 2006 to 2013 (n = 1,655,495 in 2006 and 2,720,777 in 2013)...
March 10, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28272234/neovascular-glaucoma-after-vitrectomy-in-patients-with-proliferative-diabetic-retinopathy
#18
Jin-Woo Kwon, Donghyun Jee, Tae Yoon La
To evaluate the prevalence and risk factors of neovascular glaucoma (NVG) after vitrectomy in patients with vitreous hemorrhage associated with proliferative diabetic retinopathy (PDR). This retrospective, noncomparative, observational study included 127 eyes of 127 patients with PDR who received vitrectomy with a follow-up period of at least 6 months. The prevalence of NVG and associated risk factors were assessed including sex, age, previous panretinal photocoagulation, baseline intraocular pressure, combined phacovitrectomy, and pretreatment with intravitreal bevacizumab (IVB) before vitrectomy for the treatment of vitreous hemorrhage...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28271229/characteristics-of-patients-with-spontaneous-dislocation-of-in-the-bag-intraocular-lens-after-pars-plana-vitrectomy
#19
Takayuki Koike, Takayuki Baba, Tomohiro Nizawa, Toshiyuki Oshitari, Shuichi Yamamoto
PURPOSE: To determine the characteristics of eyes with late in-the-bag dislocation of an intraocular lens (IOL) after pars plana vitrectomy (PPV). METHODS: Fourteen eyes of 14 patients with a dislocated IOL after PPV were studied retrospectively. The data collected from the medical charts included the age, sex, history of eye diseases, axial length, and interval from PPV to time of IOL dislocation. The surgical procedures used during the PPV were also recorded. RESULTS: Seven eyes had undergone PPV for rhegmatogenous retinal detachment; 6 eyes, for proliferative diabetic retinopathy; and 1 eye, for retinal vein occlusion...
March 7, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28264049/vitreous-advanced-glycation-endproducts-and-%C3%AE-dicarbonyls-in-retinal-detachment-patients-with-type-2-diabetes-mellitus-and-non-diabetic-controls
#20
Bernardina T Fokkens, Douwe J Mulder, Casper G Schalkwijk, Jean L Scheijen, Andries J Smit, Leonoor I Los
PURPOSE: Advanced glycation endproducts (AGEs) and their precursors α-dicarbonyls are implicated in the progression of diabetic retinopathy. The purpose of this study was to assess AGEs and α-dicarbonyls in the vitreous of patients with type 2 diabetes mellitus (T2DM) with early stages or absence of diabetic retinopathy. METHODS: We examined vitreous samples obtained during vitrectomy from 31 T2DM patients presenting themselves with rhegmatogenous retinal detachment and compared these to 62 non-diabetic rhegmatogenous retinal detachment patients, matched on age, estimated glomerular filtration rate, smoking, intra-ocular lens implantation, and proliferative vitreoretinopathy...
2017: PloS One
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