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Diabetic Vitrectomy

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https://www.readbyqxmd.com/read/28719903/thinning-of-inner-retinal-layers-after-vitrectomy-with-silicone-oil-versus-gas-endotamponade-in-eyes-with-macula-off-retinal-detachment
#1
Konstantine Purtskhvanidze, Jost Hillenkamp, Jan Tode, Olaf Junge, Jürgen Hedderich, Johann Roider, Felix Treumer
PURPOSE: To evaluate retinal layer thickness with optical coherence tomography (OCT) in eyes with macula-off retinal detachment after silicone oil (SiO) or gas endotamponade. PROCEDURES: Cross-sectional study of 40 eyes with macula-off rhegmatogenous retinal detachment that underwent vitrectomy. 20 eyes received SiO tamponade and 20 matched eyes received gas. 33 healthy fellow eyes served as controls. Macular spectral domain OCT was performed with automated layer detection in the 5 inner subfields of the Early Treatment Diabetic Retinopathy Study (ETDRS) map...
July 19, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28704441/a-comparison-of-sex-steroid-concentration-levels-in-the-vitreous-and-serum-of-patients-with-vitreoretinal-diseases
#2
Yuko Nishikawa, Seita Morishita, Taeko Horie, Masanori Fukumoto, Takaki Sato, Teruyo Kida, Hidehiro Oku, Jun Sugasawa, Tsunehiko Ikeda, Kimitoshi Nakamura
The purpose of this study was to compare steroid hormone concentration levels in the vitreous and serum of vitreoretinal disease patients to elucidate the possibility of neurosteroid production in the retina. Serum and vitreous samples were collected from vitrectomy patients, and estradiol (E2) and testosterone (T) concentrations were measured using electro-chemiluminescence immunoassay. We measured E2 in epiretinal membrane (ERM, n = 14), macular hole (MH, n = 18), proliferative diabetic retinopathy (PDR, n = 20), and retinal detachment (RD, n = 19) cases, and T in ERM (n = 14), MH (n = 17), PDR (n = 13), and RD (n = 17) cases...
2017: PloS One
https://www.readbyqxmd.com/read/28678306/beneficial-effects-of-phytochemicals-in-diabetic-retinopathy-experimental-and-clinical-evidence
#3
S Ojha, V Balaji, B Sadek, M Rajesh
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus and a major preventable cause of blindness. Strict control of blood glucose, blood pressure, and lipid profiles are the pivotal criteria to reduce the risk of developing DR. Although timely intervention with laser photocoagulation therapy could mitigate the progression of DR, it may not significantly improve visual acuity. Therefore, invasive surgical interventions such as vitrectomy are sometimes the only option to treat or manage advanced stages of DR...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28670654/comparative-study-of-27-gauge-and-25-gauge-vitrectomy-performed-as-day-surgery
#4
Ryusaburo Mori, Saigen Naruse, Hiroyuki Shimada
PURPOSE: To compare postoperative outcomes of 27-gauge (G) and 25-G vitrectomy conducted as day surgery. METHODS: In total, 200 consecutive eyes that underwent primary vitrectomy (27-G in 100 eyes, 25-G in 100 eyes) were analyzed. 27-G vitrectomy was performed using a cut rate of 7500 cpm and 25-G vitrectomy using a cut rate of 5000 cpm. RESULTS: The 27-G and 25-G groups did not differ significantly in underlying diseases and preoperative Early Treatment Diabetic Retinopathy Study (ETDRS) score...
July 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28669777/impaired-autoregulation-of-blood-flow-at-the-optic-nerve-head-during-vitrectomy-in-patients-with-type-2-diabetes
#5
Ryuya Hashimoto, Tetsuya Sugiyama, Hidetaka Masahara, Masashi Sakamoto, Makoto Ubuka, Takatoshi Maeno
PURPOSE: To determine whether type 2 diabetes (T2DM) influences autoregulation of optic nerve head (ONH) blood flow during vitrectomy. DESIGN: Cohort study METHODS: Thirteen eyes of 13 subjects with T2DM and 30 eyes of 30 controls without T2DM undergoing vitrectomy for epiretinal membrane or macular hole were included. Following 25-gauge vitrectomy, we measured the mean blur rate (MBR), an index of ONH blood flow, in the vascular area (vascular MBR) and in the tissue area (tissue MBR) using laser speckle flowgraphy...
June 29, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28632410/correlation-between-interleukin-6-and-thrombin-antithrombin-iii-complex-levels-in-retinal-diseases
#6
Rita Ehrlich, Alon Zahavi, Ruth Axer-Siegel, Ivan Budnik, Ayelet Dreznik, Mor Dahbash, Yael Nisgav, Elinor Megiddo, Gili Kenet, Dov Weinberger, Tami Livnat
PURPOSE: This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin-antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies. METHODS: Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical center. Patients were divided by the underlying vitreoretinal pathophysiology, as follows: macular hole (MH)/epiretinal membrane (ERM) (n = 26); rhegmatogenous retinal detachment (RRD) (n = 32); and proliferative diabetic retinopathy (PDR) (n = 20)...
June 20, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28627981/early-vitrectomy-for-dense-vitreous-hemorrhage-in-adults-with-non-traumatic-and-non-diabetic-retinopathy
#7
Ting Zhang, Jingjing Zhang, Xiaolei Sun, Jingyi Tian, Weiyun Shi, Gongqiang Yuan
Objective To evaluate the etiologies for dense vitreous hemorrhage in adults with non-traumatic and reveal management of early vitrectomy for the disease. Methods Study included 105 eyes from 105 patients. Outcome measures were etiologies of vitreous hemorrhage, formation of retinal and/or disk neovascular membrane (NVM), incidence of retinal tear and detachment, visual acuity (VA) and postoperative complications. Results Mean time between presentation and surgery was 7.1 days. The most common etiologies were retinal vein occlusion (RVO) (58...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28587359/effect-of-three-dimensional-reconstruction-assisted-23g-micro-invasive-vitrectomy-in-patients-with-proliferative-diabetic-retinopathy
#8
Min Fu, Xiaohe Lu, Huijun Hu, Songfu Feng, Wei Wu, Xiaoyun Ke, Xiaoping Xu, Xiaohong Chen, Huiqiao Hai
In the present study, we investigated the effect of optical coherence tomography (OCT) three-dimensional reconstruction-assisted 23G micro-invasive vitrectomy (abbreviated to'23G') in patients with proliferative diabetic retinopathy (PDR). A total of 66 PDR patients (66 eyes) were continuously selected and randomly divided into the control and observation groups with 33 patients in each group. Patients in the control group were treated with routine OCT examination while the patients in the observation group were treated with OCT three-dimensional retinal reconstruction...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28576207/effect-of-air-and-sulfur-hexafluoride-sf6-tamponade-on-visual-acuity-after-epiretinal-membrane-surgery-a-pilot-study
#9
Guillaume Chabot, Serge Bourgault, Benoit Cinq-Mars, Éric Tourville, Mathieu Caissie
OBJECTIVE: The aim of this study was to compare visual acuity improvement after epiretinal membrane (ERM) surgery using air and sulfur hexafluoride (SF6) tamponade. Secondary objectives were to evaluate Visual Function Questionnaire (VFQ) scores and central retinal thickness (CRT) changes. DESIGN: This was a prospective, randomized study. PARTICIPANTS: Thirty-two patients were prospectively randomized, 19 to the air group and 13 to the SF6 group...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28574495/black-patients-sustain-vision-loss-while-white-and-south-asian-patients-gain-vision-following-delamination-or-segmentation-surgery-for-tractional-complications-associated-with-proliferative-diabetic-retinopathy
#10
R Mastropasqua, Y H-L Luo, Y S Cheah, C Egan, J J Lewis, L da Cruz
PurposeThis retrospective comparative case series aims to determine whether patient ethnicity (White versus South Asian versus Black) is related to the outcome of surgical treatment for traction complications of severe proliferative diabetic retinopathy (PDR).SettingMoorfields Eye Hospital London, UK.MethodsAll patients who underwent vitrectomy with, delamination and/or segmentation for PDR over a 5-year period (2009-2014) were reviewed retrospectively. Patients were divided into White, South Asian or Black groups, and their age, gender, HbA1C and type of diabetes were recorded...
June 2, 2017: Eye
https://www.readbyqxmd.com/read/28572674/cytokine-profiling-in-the-sub-silicone-oil-fluid-after-vitrectomy-surgeries-for-refractory-retinal-diseases
#11
Hiroki Kaneko, Kei Takayama, Tetsu Asami, Yasuki Ito, Taichi Tsunekawa, Takeshi Iwase, Yasuhito Funahashi, Shinji Ueno, Norie Nonobe, Shunsuke Yasuda, Ayana Suzumura, Hideyuki Shimizu, Reona Kimoto, Shiang-Jyi Hwang, Hiroko Terasaki
Silicone oil (SO) is an intraocular surgical adjuvant that reduces the surgical complications in refractory retinal diseases, although membrane and cellular proliferation is often seen even in SO-filled eyes. We hypothesised that the fluid in the space between the SO and the retina, named the "sub-silicone oil fluid (SOF)", enhances these biological responses. We proposed a safe method for SOF extraction. We also analysed inflammatory cytokine expressions and SOF osmotic pressures from eyes with rhegmatogenous retinal detachment (RRD), proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR) and macular hole-associated retinal detachment (MHRD)...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28570745/nd-yag-laser-vitreolysis-versus-pars-plana-vitrectomy-for-vitreous-floaters
#12
REVIEW
Jan Kokavec, Zhichao Wu, Justin C Sherwin, Alan Js Ang, Ghee Soon Ang
BACKGROUND: The vitreous is the clear jelly of the eye and contains fine strands of proteins. Throughout life the composition of this vitreous changes, which causes the protein strands in it to bundle together and scatter light before it reaches the retina. Individuals perceive the shadows cast by these protein bundles as 'floaters'. Some people are so bothered by floaters that treatment is required to control their symptoms. Two major interventions for floaters include Nd:YAG laser vitreolysis and vitrectomy...
June 1, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28567164/pars-plana-vitrectomy-with-internal-limiting-membrane-peeling-for-nontractional-diabetic-macular-edema
#13
Jan Niklas Ulrich
BACKGROUND: Diabetes mellitus remains the leading cause of blindness among working age Americans with diabetic macular edema being the most common cause for moderate and severe vision loss. OBJECTIVE: To investigate the anatomical and visual benefits of pars plana vitrectomy with inner limiting membrane peeling in patients with nontractional diabetic macular edema as well as correlation of integrity of outer retinal layers on spectral domain optical coherence tomography to visual outcomes...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28558009/association-between-aqueous-humor-and-vitreous-fluid-levels-of-th17-cell-related-cytokines-in-patients-with-proliferative-diabetic-retinopathy
#14
Masaru Takeuchi, Tomohito Sato, Yutaka Sakurai, Manzo Taguchi, Kozo Harimoto, Yoko Karasawa, Masataka Ito
Inflammation is known to be involved in the progression of diabetic retinopathy. We have recently reported that vitreous levels of IL-4, IL-17A, IL-22, IL-31, and TNFα are higher than the respective serum levels in proliferative diabetic retinopathy (PDR) patients, and that vitreous levels of these cytokines are higher in PDR than in other non-inflammatory vitreoretinal diseases or uveitis associated with sarcoidosis. In the present study, we investigated inflammatory cytokines including Th17 cell-related cytokines in aqueous humor samples obtained from eyes with PDR, and analyzed the association between the aqueous humor and vitreous fluid levels of individual cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28534343/predictors-and-outcomes-of-vitrectomy-and-silicone-oil-injection-in-advanced-diabetic-retinopathy
#15
Alireza Ramezani, Hamid Ahmadieh, Amin Rozegar, Masoud Soheilian, Morteza Entezari, Siamak Moradian, Mohammad H Dehghan, Homayoun Nikkhah, Mehdi Yaseri
PURPOSE: To evaluate visual and anatomical results and identify factors that influence vitrectomy and silicone oil (SO) injection outcomes in proliferative diabetic retinopathy (PDR). METHODS: This retrospective study included 236 eyes with PDR that were undergoing vitrectomy and SO injection with >3-month follow-up. The primary outcomes were final best-corrected visual acuity (BCVA) and retinal attachment rate. RESULTS: At the final visit (mean, 88 ± 58 weeks), complete, partial, and no retinal attachment were observed in 86...
June 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28498374/ranibizumab-pretreatment-in-diabetic-vitrectomy-a-pilot-randomised-controlled-trial-the-radivit-study
#16
O Comyn, L Wickham, D G Charteris, P M Sullivan, E Ezra, Z Gregor, G W Aylward, L da Cruz, D Fabinyi, T Peto, M Restori, W Xing, C Bunce, P G Hykin, J W Bainbridge
PurposeOur aim was to evaluate the impact of intravitreal ranibizumab pretreatment on the outcome of vitrectomy surgery for advanced proliferative diabetic retinopathy. The objective was to determine the feasibility of a subsequent definitive trial and estimate the effect size and variability of the outcome measure.Patients and methodsWe performed a pilot randomised double-masked single-centre clinical trial in 30 participants with tractional retinal detachment associated with proliferative diabetic retinopathy...
May 12, 2017: Eye
https://www.readbyqxmd.com/read/28497987/elevated-activating-transcription-factor-4-and-glucose-regulated-78-kda-protein-levels-correlate-with-inflammatory-cytokines-in-the-aqueous-humor-and-vitreous-of-proliferative-diabetic-retinopathy
#17
Yanuo Wang, Sha Gao, Yanji Zhu, Xi Shen
PURPOSE: To determine concentrations of endoplasmic reticulum (ER) stress-related factors activating transcription factor 4 (ATF4) and glucose-regulated 78 kDa protein (GRP78) in vitreous and aqueous humor (AqH) of patients with proliferative diabetic retinopathy (PDR) and the correlation of ATF4, GRP78 and inflammatory cytokines interleukin-6(IL-6) and monocyte chemoattractant protein-1 (MCP-1). MATERIALS AND METHODS: AqH and vitreous samples were collected from eyes of patients with PDR and idiopathic macular hole (IMH) which needed vitrectomy...
May 12, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28489747/postoperative-changes-in-the-retinal-thickness-and-volume-after-vitrectomy-for-epiretinal-membrane-and-internal-limiting-membrane-peeling
#18
Jae Yon Won, Mirinae Kim, Young-Hoon Park
The aim of the study was to investigate the thickness and volume profiles of each retinal layer in postoperative patients with epiretinal membranes.Twenty-four patients who underwent pars plana vitrectomy with internal limiting membrane (ILM) peeling for epiretinal membrane were included. The best corrected visual acuity, thickness, and volume were recorded from the medical records through a retrospective review. Spectral domain optical coherence tomography was used to measure the average thickness and volume of each retinal layer before surgery and 6 months postoperatively...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489694/efficacy-of-intravitreal-ranibizumab-injections-in-the-treatment-of-vitreous-hemorrhage-related-to-proliferative-diabetic-retinopathy
#19
Elias Chelala, Joseph Nehme, Hala El Rami, Roni Aoun, Ali Dirani, Ali Fadlallah, Alex Jalkh
PURPOSE: To investigate the efficacy of intravitreal ranibizumab injections in proliferative diabetic retinopathy associated with vitreous hemorrhage (VH). METHODS: A prospective study including patients with proliferative diabetic retinopathy who presented with persistent VH. Vitreous hemorrhage was graded into mild, moderate, and severe. Patients were randomized into two groups: the ranibizumab group was treated with intravitreal injections of ranibizumab and the control group was assigned to observation alone...
May 9, 2017: Retina
https://www.readbyqxmd.com/read/28435237/evaluation-of-ex-press-glaucoma-implant-in-elderly-diabetic-patients-after-23g-vitrectomy
#20
Anita Lyssek-Boroń, Adam Wylęgała, Dariusz Dobrowolski, Ewelina Kowalczyk, Katarzyna Polanowska, Edward Wylęgała
PURPOSE: The most frequent qualifications for pars plana vitrectomy (PPV) in diabetic patients include recurrent hemorrhage into the vitreous body chamber and vitreoretinal proliferation, also with traction retinal detachment. The aim of this study was to evaluate the effectiveness of EX-PRESS implant for the treatment of secondary glaucoma in elderly diabetic patients following PPV 23G with silicon oil or SF6 gas endotamponade. MATERIALS AND METHODS: This retrospective analysis comprised 18 patients (19 eyes)...
2017: Clinical Interventions in Aging
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