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Nuclear stress test

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https://www.readbyqxmd.com/read/28940689/clinical-experience-of-a-new-reference-material-for-exercise-capacity-in-exercise-stress-testing-in-sweden
#1
Thomas Lindow, Henrik Mosén, Henrik Engblom
BACKGROUND: In 2014, the Swedish Association of Clinical Physiology recommended the use of a new reference material for exercise capacity in bicycle exercise stress testing, 'the Kalmar material'. Compared to the formerly used reference material, 'the Kristianstad material', an increase in the amount of patients being classified as having decreased exercise capacity was expected, but the extent of this in clinical practice is not known. METHODS: Results of exercise capacity from 1449 bicycle exercise tests, in patients aged ≥20 years (656 women, 793 men) performed at two departments of Clinical Physiology before and after change of reference materials, were collected...
September 21, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28931410/lentivirus-mediated-interleukin-1%C3%AE-il-1%C3%AE-knock-down-in-the-hippocampus-alleviates-lipopolysaccharide-lps-induced-memory-deficits-and-anxiety-and-depression-like-behaviors-in-mice
#2
Mengmeng Li, Chenli Li, Hanjie Yu, Xiongxiong Cai, Xinbei Shen, Xin Sun, Jinting Wang, Yanhua Zhang, Chuang Wang
BACKGROUND: Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents. Interleukin-1β (IL-1β), a pro-inflammatory cytokine, has been proposed to be a key mediator in a variety of behavioral dysfunction induced by LPS in mice. Thus, inhibition of IL-1β may have a therapeutic benefit in the treatment of neuropsychiatric disorders. However, the precise underlying mechanism of knock-down of IL-1β in repairing behavioral changes by LPS remains unclear...
September 20, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28911528/macrophages-in-oxidative-stress-and-models-to-evaluate-the-antioxidant-function-of-dietary-natural-compounds
#3
REVIEW
Omir Adrian Castaneda, Sheng-Chi Lee, Chi-Tang Ho, Tzou-Chi Huang
Antioxidant testing of natural products has attracted increasing interest in recent years, mainly due to the fact that an antioxidant-rich diet might provide health benefits. Activated macrophages are a major source of reactive oxygen species, reactive nitrogen species, and peroxynitrite generated through the so-called respiratory burst. Constitutively released proinflammatory cytokine, especially tumor necrosis factor-α, triggers nuclear factor-κB, and activator protein-1 translocation leading to the over production of reactive oxygen species and reactive nitrogen species in macrophages...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28910997/paediatric-nuclear-medicine-imaging
#4
Lorenzo Biassoni, Marina Easty
Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Sources of data: The data presented comes from clinical experience and some milestone papers on the subject...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28900834/coq10-increases-mitochondrial-mass-and-polarization-atp-and-oct4-potency-levels-and-bovine-oocyte-mii-during-ivm-while-decreasing-ampk-activity-and-oocyte-death
#5
M K Abdulhasan, Q Li, J Dai, H M Abu-Soud, E E Puscheck, D A Rappolee
PURPOSE: We tested whether mitochondrial electron transport chain electron carrier coenzyme Q10 (CoQ10) increases ATP during bovine IVM and increases %M2 oocytes, mitochondrial polarization/mass, and Oct4, and decreases pAMPK and oocyte death. METHODS: Bovine oocytes were aspirated from ovaries and cultured in IVM media for 24 h with 0, 20, 40, or 60 μM CoQ10. Oocytes were assayed for ATP by luciferase-based luminescence. Oocyte micrographs were quantitated for Oct4, pAMPK (i...
September 12, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28900141/dianxianning-improved-amyloid-%C3%AE-induced-pathological-characteristics-partially-through-daf-2-daf-16-insulin-like-pathway-in-transgenic-c-elegans
#6
Dejuan Zhi, Dong Wang, Wenqi Yang, Ziyun Duan, Shuqian Zhu, Juan Dong, Na Wang, Ningbo Wang, Dongqing Fei, Zhanxin Zhang, Xin Wang, Meizhu Wang, Hongyu Li
Dianxianning (DXN) is a traditional Chinese formula, and has been approved in China for treating epilepsy since 1996. Here anti-Alzheimer's disease activity of DXN has been reported. DXN improved AD-like symptoms of paralysis and 5-HT sensitivity of transgenic Aβ1-42 C. elegans. In worms, DXN significantly increased Aβ monomers and decreased the toxic Aβ oligomers, thus reducing Aβ toxicity. DXN significantly suppressed the expression of hsp-16.2 induced by juglone, and up-regulated sod-3 expression. These results indicated that DXN increased stress resistance and protected C...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899227/phenethyl-isothiocyanate-protects-against-h2o2-induced-insulin-resistance-in-3t3-l1-adipocytes
#7
Moe Nagami, Yoshiaki Ito, Takashi Nagasawa
Obesity is associated with systemic oxidative stress and leads to insulin resistance. Phenethyl isothiocyanate (PEITC), a natural dietary isothiocyanate, has been shown to have beneficial effects in improving cellular defense activities against oxidative stress through activation of nuclear factor erythroid-2 related factor 2 (Nrf2) pathway. However, little evidence exists if the antioxidative activity has beneficial effects on glucose metabolism. Here, we tested the preventive potential of PEITC for impaired insulin-induced glucose uptake by oxidative stress in 3T3-L1 adipocytes...
September 13, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28898431/anti-inflammatory-and-anti-oxidant-properties-of-schisandrin-c-promote-mitochondrial-biogenesis-in-human-dental-pulp-cells
#8
J S Takanche, Y-H Lee, J-S Kim, J-E Kim, S-H Han, S-W Lee, H-K Yi
AIM: To examine the properties of Schisandrin C as an anti-inflammatory and anti-oxidant compound, and whether its characteristics promote mitochondrial biogenesis in human dental pulp cells (HDPCs). METHODOLOGY: HDPCs were extracted from fresh third molars and cultured for experiments. Reactive oxidative stress (ROS) and nitric oxide (NO) formation were analyzed by a Muse cell analyzer. Western blotting and gelatin zymography were used to identify the presence of anti-oxidants, as well as anti-inflammatory and mitochondrial biogenesis with specific antibody...
September 12, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28894373/curcumin-inhibits-apoptosis-by-modulating-bax-bcl-2-expression-and-alleviates-oxidative-stress-in-testes-of-streptozotocin-induced-diabetic-rats
#9
Lingling Zhao, Qianru Gu, Lanting Xiang, Xidan Dong, Huimin Li, Jinyao Ni, Li Wan, Guoping Cai, Guorong Chen
SCOPE: The present study was designed to examine the damage caused by high-fat diet and streptozotocin-induced diabetes on the testis of rats and the effects of curcumin against oxidative stress and apoptosis from high-fat diet and diabetes. METHODS: Diabetes was induced by intraperitoneal injection of streptozotocin (30 mg/kg in 0.1 M sodium citrate buffer, pH 4.5) in obese rats. The rats in the obese and diabetic groups were treated with a daily dose of curcumin by intragastric intubation (100 mg/kg body weight) for 8 weeks...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28892792/bamboo-leaf-extract-ameliorates-cardiac-fibrosis-possibly-via-alleviating-inflammation-oxidative-stress-and-apoptosis
#10
Lili Zhang, Yizhen Mao, Jiajun Pan, Shanshan Wang, Lei Chen, Jie Xiang
Previous studies have shown that inflammatory process contributes to the pathogenesis of cardiac damage induced by diabetes mellitus. However, the underlying mechanisms and strategies to alleviate inflammatory injury in the diabetic heart are not fully elucidated. In this study, we investigated the potential role and related mechanism of bamboo leaf extract (BLE) on diabetes-induced cardiac fibrosis in rats. Diabetes was induced by streptozocin (STZ) in rats, blood glucose and glycosylated hemoglobin A1c (HbAlc) were measured...
September 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28884318/implications-of-fals-mutations-on-sod1-function-and-oligomerization-in-cell-models
#11
Aline A Brasil, Rayne S S Magalhães, Mariana D C De Carvalho, Isabel Paiva, Ellen Gerhardt, Marcos D Pereira, Tiago F Outeiro, Elis C A Eleutherio
Among the familial forms of amyotrophic lateral sclerosis (fALS), 20% are associated with the Cu,Zn-superoxide dismutase (Sod1). fALS is characterized by the accumulation of aggregated proteins and the increase in oxidative stress markers. Here, we used the non-invasive bimolecular fluorescence complementation (BiFC) assay in human H4 cells to investigate the kinetics of aggregation and subcellular localization of Sod1 mutants. We also studied the effect of the different Sod1 mutants to respond against oxidative stress by following the levels of reactive oxygen species (ROS) after treatment with hydrogen peroxide...
September 7, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28883695/schistosoma-japonicum-attenuates-dextran-sodium-sulfate-induced-colitis-in-mice-via-reduction-of-endoplasmic-reticulum-stress
#12
Ya Liu, Qing Ye, Yu-Lan Liu, Jian Kang, Yan Chen, Wei-Guo Dong
AIM: To elucidate the impact of Schistosoma (S.) japonicum infection on inflammatory bowel disease by studying the effects of exposure to S. japonicum cercariae on dextran sodium sulfate (DSS)-induced colitis. METHODS: Infection was percutaneously established with 20 ± 2 cercariae of S. japonicum, and colitis was induced by administration of 3% DSS at 4 wk post infection. Weight change, colon length, histological score (HS) and disease activity index (DAI) were evaluated...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28875366/saikosaponin-d-relieves-unpredictable-chronic-mild-stress-induced-depressive-like-behavior-in-rats-involvement-of-hpa-axis-and-hippocampal-neurogenesis
#13
Hong-Yan Li, Ying-Hua Zhao, Min-Jie Zeng, Fang Fang, Min Li, Ting-Ting Qin, Lu-Yu Ye, Hong-Wei Li, Rong Qu, Shi-Ping Ma
RATIONALE: Saikosaponin D (SSD), a major bioactive component isolated from Radix Bupleuri, has been reported to exert neuroprotective properties. OBJECTIVES: The present study was designed to investigate the anti-depressant-like effects and the potential mechanisms of SSD. METHODS: Behavioural tests including sucrose preference test (SPT), open field test (OFT) and forced swim test (FST) were performed to study the antidepressant-like effects of SSD...
September 5, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28870676/hypothermic-oxygenated-perfusion-hope-for-fatty-liver-grafts-in-rats-and-humans
#14
P Kron, A Schlegel, L Mancina, P-A Clavien, P Dutkowski
BACKGROUND: Pretreatment of marginal organs by perfusion is a promising opportunity to consider more organs for transplantation. Protection of human DCD (donation after cardiac death) livers by a novel machine perfusion technique, hypothermic oxygenated perfusion (HOPE), was recently established. Here we tested in a rodent transplant model, whether HOPE is also useful for fatty liver grafts. METHODS: Rats were fed over 3 weeks with a special Methionine-Choline-Deficient-Diet (MCDD) to induce severe hepatic macrosteatosis (≥60%)...
September 1, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28870649/lipopolysaccharide-impairs-permeability-of-pulmonary-microvascular-endothelial-cells-via-connexin40
#15
Hua-Song Zhou, Meng Li, Bing-Dong Sui, Lei Wei, Rui Hou, Wen-Sheng Chen, Qiang Li, Sheng-Hui Bi, Jin-Zhou Zhang, Ding-Hua Yi
The endotoxin lipopolysaccharide (LPS)-induced pulmonary endothelial barrier disruption is a key pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the molecular mechanisms underlying LPS-impaired permeability of pulmonary microvascular endothelial cells (PMVECs) are not fully understood. Gap junctions, particularly Connexin40 (Cx40), are necessary for the maintenance of normal vascular function. In this study, we for the first time investigated the role of Cx40 in LPS-impaired permeability of PMVECs and provided potential therapeutic approaches based on mechanistic findings of Cx40 regulation by LPS stimuli...
September 1, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28868838/aluminium-induced-oxidative-stress-apoptosis-and-alterations-in-testicular-tissue-and-sperm-quality-in-wistar-rats-ameliorative-effects-of-curcumin
#16
Ebrahim Cheraghi, Alireza Golkar, Kambiz Roshanaei, Behrang Alani
Background: Reproductive toxicity is a major challenge associated with aluminum (Al) exposure. No studies have evaluated the possible effects of curcumin (CUR) on Al-induced reproductive dysfunction. Therefore, this study investigated the effects of CUR treatment on Al-induced reproductive damage. MATERIALS AND METHODS: In this experimental study, 40 male Wistar rats were allocated to the five groups (n=8) based on the treatment they received: no treatment (control), solvent [dimethyl sulfoxide (DMSO) or distilled water], CUR 10 mg/kg body weight (BW), Al chloride 10 mg/kg BW, and CUR+Al chloride (10 mg/kg BW/each alone)...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28868219/appraisal-of-biochemical-classes-of-radioprotectors-evidence-current-status-and-guidelines-for-future-development
#17
REVIEW
Krishnanand Mishra, Ghazi Alsbeih
The search for efficient radioprotective agents to protect from radiation-induced toxicity, due to planned or accidental radiation exposure, is still ongoing worldwide. Despite decades of research and development of widely different biochemical classes of natural and derivative compounds, a safe and effective radioprotector is largely unmet. In this comprehensive review, we evaluated the evidence for the radioprotective performance of classical thiols, vitamins, minerals, dietary antioxidants, phytochemicals, botanical and bacterial preparations, DNA-binding agents, cytokines, and chelators including adaptogens...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28865081/chronic-treatment-with-zoledronic-acid-increases-inflammatory-markers-in-periodontium-of-rats
#18
Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira Junior, Camila Carvalho de Oliveira, Luiz André Cavalcante Brizeno, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima Júnior, Fabrício Bitú Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves
BACKGROUND: Bisphosphonates (BF) rises proinflammatory markers and irreversibly binds to bone. Chronically BF can lead to an inflammatory status and can increase the local oxidative stress in periodontium. Therefore, the objective of this study was evaluated if the chronic infusion of Zoledronic Acid (ZA) increases inflammatory markers in periodontium of rats. METHODS AND RESULTS: Chronically infusion therapy was performed with ZA (0.04, 0.2 or 1 mg/kg or saline) by four doses in over a 70-day period to analysis periodontium of the first right inferior molar using histologic, histochemical (toluidine blue) and immunohistochemical (CD68, Tumor Necrosis Factor-α (TNF-α), Interleukin-1beta (IL-1β), Inducible Nitric Oxide Synthase (iNOS) and Nuclear Factor kappa B (NF-kB)) tests...
September 2, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28859148/stellate-ganglion-block-attenuates-chronic-stress-induced-depression-in-rats
#19
Weiwei Wang, Weidong Shi, Hua Qian, Xijin Deng, Tong Wang, Wenzhi Li
BACKGROUND: Stress is a significant factor in the etiology of depression. Stellate ganglion block (SGB) has been shown to maintain the stability of the autonomic system and to affect the neuroendocrine system, including the hypothalamic-pituitary-adrenal (HPA) axis. The objective of this study was to determine the antidepressant-like effects of SGB on the autonomic system and the HPA axis, apoptosis-related proteins, related spatial learning and memory impairment, and sensorimotor dysfunction...
2017: PloS One
https://www.readbyqxmd.com/read/28851995/melatonin-ameliorates-restraint-stress-induced-oxidative-stress-and-apoptosis-in-testicular-cells-via-nf-%C3%AE%C2%BAb-inos-and-nrf2-ho-1-signaling-pathway
#20
Ying Guo, Junyan Sun, Ting Li, Qiuwan Zhang, Shixia Bu, Qian Wang, Dongmei Lai
Decline in semen quality has become a global public health concern. Psychological stress is common in the current modern society and is associated with semen decline. Increasing evidence demonstrated that melatonin has anti-apoptotic and antioxidant functions. Whether melatonin can ameliorate the damage in testes induced by psychological stress has never been investigated. Here, a mouse model of restraint stress demonstrated that melatonin normalized the sperm density decline, testicular cells apoptosis, and testicular oxidative stress in stressed male mice...
August 29, 2017: Scientific Reports
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