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Nuclear stress test

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https://www.readbyqxmd.com/read/28550120/hiv-1-decreases-nrf2-are-activity-and-phagocytic-function-in-alveolar-macrophages
#1
Bashar S Staitieh, Lingmei Ding, Wendy A Neveu, Paul Spearman, David M Guidot, Xian Fan
Respiratory complications occur frequently in individuals living with human immunodeficiency-1 virus (HIV) infection, and there is evidence that HIV-related oxidative stress impairs alveolar macrophage immune function. We hypothesized that nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a master transcription factor that activates the antioxidant response element (ARE) and regulates antioxidant defenses, has an important role in alveolar macrophage (AMs) immune dysfunction in individuals with HIV infections...
May 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28542382/uv-b-induced-fibrillization-of-crystallin-protein-mixtures
#2
Sibel Cetinel, Valentyna Semenchenko, Jae-Young Cho, Mehdi Ghaffari Sharaf, Karim F Damji, Larry D Unsworth, Carlo Montemagno
Environmental factors, mainly oxidative stress and exposure to sunlight, induce the oxidation, cross-linking, cleavage, and deamination of crystallin proteins, resulting in their aggregation and, ultimately, cataract formation. Various denaturants have been used to initiate the aggregation of crystallin proteins in vitro. All of these regimens, however, are obviously far from replicating conditions that exist in vivo that lead to cataract formation. In fact, it is our supposition that only UV-B radiation may mimic the observed in vivo cause of crystallin alteration leading to cataract formation...
2017: PloS One
https://www.readbyqxmd.com/read/28533929/does-ischemic-burden-on-stress-testing-influence-patient-survival-in-subjects-with-known-severe-multi-vessel-cad
#3
Shey Mukundan, Mark I Travin, Jeffrey M Levsky, Matthew P Liakos, Daniel M Spevack
BACKGROUND: Ischemic burden observed during stress testing has been postulated to predict prognosis irrespective of anatomic atherosclerotic burden observed on angiography. However, it is not known if the stress test result influences the long-term prognosis of subjects with diffuse coronary artery disease. We sought to determine the prognostic importance of stress test false negativity amongst patients with severe multi-vessel coronary artery disease (CAD) undergoing stress testing in the previous decade...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28531190/real-time-cell-toxicity-profiling-of-tox21-10k-compounds-reveals-cytotoxicity-dependent-toxicity-pathway-linkage
#4
Jui-Hua Hsieh, Ruili Huang, Ja-An Lin, Alexander Sedykh, Jinghua Zhao, Raymond R Tice, Richard S Paules, Menghang Xia, Scott S Auerbach
Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration dependent fashion in two cell lines (HEK293, HepG2) using two multiplexed, real-time assay technologies. One technology measures the metabolic activity of cells (i.e., cell viability, glo) while the other evaluates cell membrane integrity (i.e., cell death, flor). Using glo technology, more actives and greater temporal variations were seen in HEK293 cells, while results for the flor technology were more similar across the two cell types...
2017: PloS One
https://www.readbyqxmd.com/read/28529531/the-protective-effect-of-lavender-essential-oil-and-its-main-component-linalool-against-the-cognitive-deficits-induced-by-d-galactose-and-aluminum-trichloride-in-mice
#5
Pan Xu, Kezhu Wang, Cong Lu, Liming Dong, Li Gao, Ming Yan, Silafu Aibai, Yanyan Yang, Xinmin Liu
Lavender essential oil (LO) is a traditional medicine used for the treatment of Alzheimer's disease (AD). It was extracted from Lavandula angustifolia Mill. This study was designed to investigate the effects of lavender essential oil (LO) and its active component, linalool (LI), against cognitive impairment induced by D-galactose (D-gal) and AlCl3 in mice and to explore the related mechanisms. Our results revealed that LO (100 mg/kg) or LI (100 mg/kg) significantly protected the cognitive impairments as assessed by the Morris water maze test and step-though test...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28526976/how-to-achieve-patient-centered-testing-role-of-the-protocol-nurse
#6
Patricia N Salimi, Joelyn B Niggel, Friederike K Keating
INTRODUCTION: Patient-centered cardiac testing is predicated on choosing the right test for the right patient. We studied the effects of changing from script-driven scheduling to nurse-driven protocoling of stress tests. METHODS AND RESULTS: A protocol nurse reviewed records before scheduling and communicated with patients and ordering providers if needed. We found that instituting nurse protocolling of all non-imaging (ETT) and nuclear (MPI) stress tests (N = 3071) resulted in protocol changes in 37% of our patients, and reduced the proportion of tests that could not be performed as scheduled by 56% and cancelations by 71% (P < 0...
May 19, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28522335/comparative-analysis-of-transcriptomic-responses-to-repeated-dose-exposure-to-2-mcpd-and-3-mcpd-in-rat-kidney-liver-and-testis
#7
Thorsten Buhrke, Katharina Schultrich, Albert Braeuning, Alfonso Lampen
3-Chloro-1,2-propanediol (3-MCPD) and its isomer 2-chloro-1,3-propanediol (2-MCPD) are heat-induced food contaminants present in oil- and fat-containing foodstuff. Kidney and testes are among the main target organs of 3-MCPD. Almost no data on 2-MCPD toxicity are available. Here, transcriptomic responses following repeated-dose exposure of rats to non-toxic doses of 10 mg/kg body weight per day 2-MCPD or 3-MCPD for 28 days were characterized by microarray analysis of kidney, liver, and testes. 3-MCPD exerted more pronounced effects than 2-MCPD in all organs...
May 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28521491/hif-1%C3%AE-acts-as-a-molecular-target-for-simvastatin-cytotoxicity-in-b16-f10-melanoma-cells-cultured-under-chemically-induced-hypoxia
#8
Emilia Licarete, Alina Sesarman, Valentin Florian Rauca, Lavinia Luput, Laura Patras, Manuela Banciu
Our previous studies reported that one of the main mechanisms of the antitumor activity of simvastatin (SIM) in B16.F10 murine melanoma cells was associated with strong suppression of the constitutive cell production of the α subunit of the heterodimeric transcription factor hypoxia-inducible factor (HIF)-1. Thus, the present study aimed to broaden this finding under hypoxic conditions induced by incubation of B16.F10 cells with cobalt chloride, when the constitutive production of HIF-1α in these melanoma cells is amplified by inducible expression of this factor...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28515848/coronary-artery-disease-detection-limitations-of-stress-testing-in-left-ventricular-dysfunction
#9
REVIEW
Ritin Bomb, Senthil Kumar, Anand Chockalingam
Incidental diagnosis of left ventricular systolic dysfunction (LVD) is common in clinical practice. The prevalence of asymptomatic LVD (Ejection Fraction, EF < 50%) is 6.0% in men and 0.8% in women and is twice as common as symptomatic LVD. The timely and definitive exclusion of an ischemic etiology is central to optimizing care and reducing mortality in LVD. Advances in cardiovascular imaging provide many options for imaging of patients with left ventricular dysfunction. Clinician experience, patient endurance, imaging modality characteristics, cost and safety determine the choice of testing...
April 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28515158/the-anti-psoriatic-drug-monomethylfumarate-increases-nuclear-factor-erythroid-2-related-factor-2-nrf2-levels-and-induces-aquaporin-3-aqp3-mrna-and-protein-expression
#10
Inas Helwa, Vivek Choudhary, Xunsheng Chen, Ismail Kaddour-Djebbar, Wendy B Bollag
BACKGROUND: Oxidative stress contributes to inflammatory skin diseases including psoriasis. Monomethylfumarate (MMF) is an anti-psoriatic agent with a poorly understood mechanism of action. In other cell types MMF increases the expression of nuclear factor erythroid-derived 2-like 2 (Nrf2), a transcription factor that regulates cellular anti-oxidant responses, to reduce oxidative stress like that observed in inflammatory disorders such as multiple sclerosis. OBJECTIVE: We tested the hypothesis that MMF enhances Nrf2 activity in keratinocytes, thereby improving their capacity to counteract environmental stresses...
May 17, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28505604/nrf2-and-nf-%C3%AE%C2%BAb-modulation-by-plumbagin-attenuates-functional-behavioural-and-biochemical-deficits-in-rat-model-of-neuropathic-pain
#11
Vijay Arruri, Prashanth Komirishetty, Aparna Areti, Siva Kumar Naik Dungavath, Ashutosh Kumar
BACKGROUND: Plumbagin is known to exhibit a broad range of biological activities including anti-cancer, antimicrobial and has been widely used traditionally. Nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) inhibitory and Nuclear factor (erythroid derived-2) like-2 (Nrf2) modulatory activities of Plumbagin have been reported already. In nerve injury model of neuropathy in rats, the role of NF-κB upregulation and declined antioxidant defence has been well recognized...
February 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28499974/prefrontal-cortical-glutathione-dependent-defense-and-proinflammatory-mediators-in-chronically-isolated-rats-modulation-by-fluoxetine-or-clozapine
#12
Nevena Todorović, Dragana Filipović
Chronic psychosocial stress modulates brain antioxidant systems and causes neuroinflammation that plays a role in the pathophysiology of depression. Although the antidepressant fluoxetine (FLX) represents the first-line treatment for depression and the atypical antipsychotic clozapine (CLZ) is considered as a second-line treatment for psychotic disorders, the downstream mechanisms of action of these treatments, beyond serotonergic or dopaminergic signaling, remain elusive. We examined behavioral changes, glutathione (GSH)-dependent defense and levels of proinflammatory mediators in the prefrontal cortex (PFC) of adult male Wistar rats exposed to 21days of chronic social isolation (CSIS)...
May 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/28475120/protective-effect-of-fragaria-ananassa-crude-extract-on-cadmium-induced-lipid-peroxidation-antioxidant-enzymes-suppression-and-apoptosis-in-rat-testes
#13
Mohammed I Y Elmallah, Manal F Elkhadragy, Ebtesam M Al-Olayan, Ahmed E Abdel Moneim
Cadmium is a deleterious environmental pollutant that threats both animals and human health. Oxidative stress and elevated levels of reactive oxygen species (ROS) have recently been reported to be the main cause of cellular damage as a result of cadmium exposure. We investigate, here, the protective effect of strawberry crude extracts on cadmium-induced oxidative damage of testes in rats. Four groups (n = 8) of 32 adult male Wistar rats weighing 160-180 g were used. The control group received 0.9% saline solution all over the experimental period (5 days)...
May 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28473305/quality-of-social-media-and-web-based-information-regarding-inappropriate-nuclear-cardiac-stress-testing-and-the-choosing-wisely-campaign-a-cross-sectional-study
#14
David E Winchester, Diana Baxter, Merry J Markham, Rebecca J Beyth
BACKGROUND: The World Wide Web and social media provide the public with access to medical information unlike any other time in human history. However, the quality of content related to cardiac stress testing is not well understood. OBJECTIVE: The aim of our study was to evaluate the quality of content on the Internet relating to the use of cardiac nuclear stress testing and the Choosing Wisely campaign. METHODS: We searched the World Wide Web, Google Video (including YouTube), and Twitter for information relating to these two topics...
May 4, 2017: Interactive Journal of Medical Research
https://www.readbyqxmd.com/read/28471373/identification-and-expression-profiling-of-the-auxin-response-factors-in-dendrobium-officinale-under-abiotic-stresses
#15
Zhehao Chen, Ye Yuan, Di Fu, Chenjia Shen, Yanjun Yang
Auxin response factor (ARF) proteins play roles in plant responses to diverse environmental stresses by binding specifically to the auxin response element in the promoters of target genes. Using our latest public Dendrobium transcriptomes, a comprehensive characterization and analysis of 14 DnARF genes were performed. Three selected DnARFs, including DnARF1, DnARF4, and DnARF6, were confirmed to be nuclear proteins according to their transient expression in epidermal cells of Nicotiana benthamiana leaves. Furthermore, the transcription activation abilities of DnARF1, DnARF4, and DnARF6 were tested in a yeast system...
May 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28468966/protein-disulfide-isomerase-regulates-renal-at1-receptor-function-and-blood-pressure-in-rats
#16
Xitao Wang, Mohammad Asghar
Role and mechanism of renal PDI in blood pressure (BP) regulation has not been tested before. Here, we are testing this possibility in Sprague-Dawley (SD) rats. Rats were treated with PDI inhibitor bacitracin (100mg/kg, i.p./day for 14 days) followed by determining BP and renal AT1 receptor (AT1R) function in anesthetized rats. Renal AT1R function was determined as the ability of candesartan (an AT1R blocker) to increase diuresis and natriuresis. Second set of vehicle and bacitracin treated rats were used to determine biochemical parameters...
May 3, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28463035/inhibition-of-nf-%C3%AE%C2%BAb-tnf-%C3%AE-pathway-may-be-involved-in-the-protective-effect-of-resveratrol-against-cyclophosphamide-induced-multi-organ-toxicity
#17
Azza A El-Sheikh, Mohamed A Morsy, Ahmed M Okasha
CONTEXT: Cyclophosphamide (CyP), an efficient anticancer drug, may damage normal human cells. Resveratrol (RES), a natural polyphenol, has a diverse pharmacological properties. OBJECTIVE: To test possible protective effect of RES on multi-organ damage caused by CyP. MATERIALS AND METHODS: RES (10 mg/kg/day) was administered orally for 8 days. In independent rat groups, CyP toxicity was induced via a single dose of 150 mg/kg i.p. 3 days before the end of experiment, with or without RES treatment...
May 2, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28457936/epigallocatechin-gallate-upregulates-nrf2-to-prevent-diabetic-nephropathy-via-disabling-keap1
#18
Weixia Sun, Xiuxia Liu, Haifeng Zhang, Yanyan Song, Tie Li, Xiaona Liu, Yanze Liu, Le Guo, Fuchun Wang, Ting Yang, Weiying Guo, Junduo Wu, Hang Jin, Hao Wu
Epigallocatechin gallate (EGCG) is the most abundant and effective green tea catechin and has been reported to attenuate diabetic nephropathy (DN). However, the mechanism by which EGCG ameliorates DN, till now, has remained unclear. EGCG is known as a potent activator of nuclear factor erythroid 2-related factor 2 (NRF2), which plays a key role in cellular defense against diabetes-induced oxidative stress and in the prevention of DN. In the present study, we tested whether NRF2 is required for EGCG protection against DN...
April 27, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28452734/-influence-of-ionizing-radiation-on-the-locomotor-activity-and-body-weight-of-rats
#19
A Saimova, N Chaizhunusоva, Y Kairkhanova, D Uzbеkоv, М Hоshi
The aim of our study was to study influence of ionizing radiation on the locomotor activity and body weight of rats, for this animals was irradiated by via inhalation. Beta- emitter 56Mn was obtained by neutron activation of powdered MnО2 by using nuclear reactor IVG.1M (experimental facility «Baikal-1», Kurchatov, Kazakhstan). Exposure of rats to radioactive powder had two way, the first experiment was contained only air filter for animal's breathing and the second with the system of forced ventilation...
February 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28448946/oral-administration-of-methysticin-improves-cognitive-deficits-in-a-mouse-model-of-alzheimer-s-disease
#20
Athanassios Fragoulis, Stephanie Siegl, Markus Fendt, Sandra Jansen, Ulf Soppa, Lars-Ove Brandenburg, Thomas Pufe, Joachim Weis, Christoph Jan Wruck
INTRODUCTION: There is increasing evidence for the involvement of chronic inflammation and oxidative stress in the pathogenesis of Alzheimer's disease (AD). Nuclear factor erythroid 2-related factor 2 (Nrf2) is an anti-inflammatory transcription factor that regulates the oxidative stress defense. Our previous experiments demonstrated that kavalactones protect neuronal cells against Amyloid β (Aβ)-induced oxidative stress in vitro by Nrf2 pathway activation. Here, we tested an in vivo kavalactone treatment in a mouse model of AD...
April 19, 2017: Redox Biology
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