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https://www.readbyqxmd.com/read/29775722/inflammatory-and-oxidative-mechanisms-potentiate-bifenthrin-induced-neurological-alterations-and-anxiety-like-behavior-in-adult-rats
#1
Brahim Gargouri, Harsharan S Bhatia, Michèle Bouchard, Bernd L Fiebich, Hamadi Fetoui
Bifenthrin (BF) is a synthetic pyrethroid pesticide widely used in several countries to manage insect pests on diverse agricultural crops. Growing evidence indicates that BF exposure is associated with an increased risk of developing neurodegenerative disorders. However, the mechanisms by which BF induces neurological and anxiety alterations in the frontal cortex and striatum are not well known. The present in vivo study was carried out to determine whether reactive oxygen species (ROS)-mediated oxidative stress (OS) and neuroinflammation are involved in such alterations...
May 15, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29775613/suppression-of-nlrp3-inflammasome-attenuates-stress-induced-depression-like-behavior-in-nlgn3-deficient-mice
#2
Ze-Qun Li, Zhi-Yuan Yan, Bo-Jun Lan, Yi-Qun Dong, Ye Xiong
Depression, regulated by central nervous system (CNS), is a significant inflammatory disorder. Neuroligin3 (NLGN3) has been implicated in brain functions. In the study, a chronic unpredictable mild stress (CUMS) model in wild type (WT) or NLGN3-knockout (KO) mice was established to explore the role of NLGN3 in regulating depression and to reveal the underlying molecular mechanism. The results indicated that NLGN3-knockout markedly reversed the loss of body weight, the reduction of sucrose consumption, the decrease of immobile time in the forced swimming tests (FST) and tail suspension tests (TST) induced by CUMS paradigm...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29772801/ogt-o-glcnac-transferase-selectively-modifies-multiple-residues-unique-to-lamin-a
#3
Dan N Simon, Amanda Wriston, Qiong Fan, Jeffrey Shabanowitz, Alyssa Florwick, Tejas Dharmaraj, Sherket B Peterson, Yosef Gruenbaum, Cathrine R Carlson, Line M Grønning-Wang, Donald F Hunt, Katherine L Wilson
The LMNA gene encodes lamins A and C with key roles in nuclear structure, signaling, gene regulation, and genome integrity. Mutations in LMNA cause over 12 diseases ('laminopathies'). Lamins A and C are identical for their first 566 residues. However, they form separate filaments in vivo, with apparently distinct roles. We report that lamin A is β- O -linked N -acetylglucosamine- (O -GlcNAc)-modified in human hepatoma (Huh7) cells and in mouse liver. In vitro assays with purified O -GlcNAc transferase (OGT) enzyme showed robust O -GlcNAcylation of recombinant mature lamin A tails (residues 385⁻646), with no detectable modification of lamin B1, lamin C, or 'progerin' (Δ50) tails...
May 17, 2018: Cells
https://www.readbyqxmd.com/read/29772245/ape1-ref-1-redox-function-contributes-to-inflammatory-pain-sensitization
#4
Amira Zaky, Rabia Bouali-Benazzouz, Alexandre Favereaux, Gianluca Tell, Marc Landry
Inflammatory pain is a complex and multifactorial disorder. Apurinic/apyrimidinic endonuclease 1 (APE1), also called Redox Factor-1 (Ref-1), is constitutively expressed in the central nervous system and regulates various cellular functions including oxidative stress. In the present study, we investigated APE1 modulation and associated pain behavior changes in the complete Freund's adjuvant (CFA) model of inflammatory pain in rats. In addition we tested the anti-inflammatory effects of E3330, a selective inhibitor of APE1-redox activity, in CFA pain condition...
May 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29765479/protective-effects-of-evodiamine-in-experimental-paradigm-of-alzheimer-s-disease
#5
Dongmei Wang, Chenying Wang, Ling Liu, Sanqiang Li
Evodiamine, a major component of  Evodia rutaecarpa , has been reported to possess various pharmacological activities, including anti-inflammatory, antioxidative stress, and neuroprotective effects. Our previous study has shown that the potential effects of evodiamine on the learning and memory impairments in the transgenic mouse model of Alzheimer's disease (AD). The present study was designed to investigate neuroprotective mechanism and therapeutic potential of evodiamine against intracerebroventricular streptozotocin (ICV-STZ)-induced experimental sporadic Alzheimer's disease in mice...
June 2018: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29752770/one-carbon-cycle-support-rescues-sperm-damages-in-experimentally-induced-varicocele-in-rats
#6
Parisa Mohammadi, Hassan Hassani Bafrani, Marziyeh Tavalaee, Maurizio Dattilo, Mohammad Hossein Nasr-Esfahani
OBJECTIVES: To demonstrate that micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage following surgical varicocele in rats and that this effect is achieved without suffering a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS: Surgical varicocele was induced in adult male Wistar rats and resulted in significant damage to testis and sperm cells measured 2 and 4 months post-surgery...
May 11, 2018: BJU International
https://www.readbyqxmd.com/read/29742603/progression-of-multiple-myeloma-detected-on-cardiac-scintigraphy-with-99mtc-sestamibi
#7
Jonathan Bulzan, Jonathan Revels, Kathy Byun
It is important to understand normal and abnormal radiotracer biodistribution patterns in patients who undergo cardiac Tc-2-methoxyisobutyl-isonitrile (Tc-sestamibi) scans to provide important clinical guidance. Our case describes a 75-year-old man with a history of multiple myeloma in remission, who presented to the emergency department for unrelated chest pain and shortness of breath. The patient underwent a nuclear cardiac stress test with Tc-sestamibi scintigraphy as part of his cardiac workup. The images demonstrated diffuse radiotracer uptake in the skeletal structures raising concern for progression of multiple myeloma, of which, subsequent biopsy confirmed the presence of recurrent disease...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29727947/first-ecotoxicological-assessment-of-caretta-caretta-linnaeus-1758-in-the-mediterranean-sea-using-an-integrated-nondestructive-protocol
#8
Silvia Casini, Ilaria Caliani, Matteo Giannetti, Letizia Marsili, Silvia Maltese, Daniele Coppola, Nicola Bianchi, Tommaso Campani, Stefania Ancora, Chiara Caruso, Giovanni Furii, Mariluz Parga, Antonella D'Agostino, Maria Cristina Fossi
The loggerhead sea turtle (Caretta caretta) is a long-lived carnivorous reptile included in the IUCN Red List. The IUCN assessment for this species underlines the lack of information regarding pollution and pathogens and indicates as a priority effort to investigate and reduce the impacts of these threats. In this contest, the aim of our study was to conduct the first ecotoxicological assessment of this species in the Mediterranean Sea using a nondestructive integrated methodology. We set up and applied a monitoring protocol which includes endpoints, such as CYP1A, LPO, ENA assay, B esterases, never investigated before in this species...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29727723/identification-functional-characterization-and-expression-pattern-of-myeloid-differentiation-factor-88-myd88-in-sepiella-japonica
#9
Liping Huo, Miaomiao Bao, Zhenming Lv, Changfeng Chi, Tianming Wang, Huihui Liu
Myeloid differentiation factor 88 (MyD88) is an adaptor protein involved in the interleukin-1 receptor and Toll-like receptor-induced activation of nuclear factor-κB (NF-κB). In this study a novel isoform of MyD88 in Sepiella japonica (SjMyD88) was cloned and functionally characterized (GenBank accession no. AQY56781.1). The complete cDNA sequence of SjMyD88 was 1912 bp and contained a 1017 bp open reading frame encoding 338 amino acid residues, which was similar to its mollusk orthologues in the length. BLASTp analysis suggested the deduced amino acids sequence of SjMyD88 shared high identity to the known MyD88, for instance, 64% identity with Octopus bimaculoides...
May 1, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29722317/exendin-4-inhibits-high-altitude-cerebral-edema-by-protecting-against-neurobiological-dysfunction
#10
Zhong-Lei Sun, Xian-Feng Jiang, Yuan-Chi Cheng, Ying-Fu Liu, Kai Yang, Shuang-Long Zhu, Xian-Bin Kong, Yue Tu, Ke-Feng Bian, Zhen-Lin Liu, Xu-Yi Chen
The anti-inflammatory and antioxidant effects of exendin-4 (Ex-4) have been reported previously. However, whether (Ex-4) has anti-inflammatory and antioxidant effects on high-altitude cerebral edema (HACE) remains poorly understood. In this study, two rat models of HACE were established by placing rats in a hypoxic environment with a simulated altitude of either 6000- or 7000-m above sea level (MASL) for 72 hours. An altitude of 7000 MASL with 72-hours of hypoxia was found to be the optimized experimental paradigm for establishing HACE models...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29704151/extracellular-matrix-remodeling-and-modulation-of-inflammation-and-oxidative-stress-by-sulforaphane-in-experimental-diabetic-peripheral-neuropathy
#11
Passant E Moustafa, Noha F Abdelkader, Sally A El Awdan, Osama A El-Shabrawy, Hala F Zaki
The peripheral nervous system is one of many organ systems that can be profoundly impacted in diabetes mellitus. Diabetic peripheral neuropathy has a significant negative effect on patients' quality of life as it begins with loss of limbs' sensation and may result in lower limb amputation. This investigation aimed at exploring the effect of sulforaphane on peripheral neuropathy in diabetic rats. Experimental diabetes was induced through single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52...
April 27, 2018: Inflammation
https://www.readbyqxmd.com/read/29696484/determining-post-test-risk-in-a-national-sample-of-stress-nuclear-myocardial-perfusion-imaging-reports-implications-for-natural-language-processing-tools
#12
Andrew E Levy, Nishant R Shah, Michael E Matheny, Ruth M Reeves, Glenn T Gobbel, Steven M Bradley
BACKGROUND: Reporting standards promote clarity and consistency of stress myocardial perfusion imaging (MPI) reports, but do not require an assessment of post-test risk. Natural Language Processing (NLP) tools could potentially help estimate this risk, yet it is unknown whether reports contain adequate descriptive data to use NLP. METHODS: Among VA patients who underwent stress MPI and coronary angiography between January 1, 2009 and December 31, 2011, 99 stress test reports were randomly selected for analysis...
April 25, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29695420/human-cytomegalovirus-protein-pul38-prevents-premature-cell-death-by-binding-to-ubiquitin-specific-protease-24-and-regulating-iron-metabolism
#13
Yamei Sun, Qunchao Bao, Baoqin Xuan, Wenjia Xu, Deng Pan, Qi Li, Zhikang Qian
Human cytomegalovirus (HCMV) protein pUL38 has been shown to prevent premature cell death by antagonizing cellular stress responses; however, the underlying mechanism remains unknown. In this study, we identified the host protein ubiquitin-specific protease 24 (USP24) as an interaction partner of pUL38. Mutagenesis analysis of pUL38 revealed that amino acids TFV at 227-230 were critical for its interaction with USP24. Mutant pUL38 TFV/AAA protein did not bind to USP24 and failed to prevent cell death induced by pUL38-deficient HCMV infection...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29684657/engineering-low-cadmium-rice-through-stress-inducible-expression-of-oxs3-family-member-genes
#14
Changhu Wang, Weili Guo, Xingzhe Cai, Ruyu Li, David W Ow
Cadmium (Cd) as a carcinogen poses a great threat to food security and public health through plant-derived foods such as rice, the staple for nearly half of the world's population. We have previously reported that overexpression of truncated gene fragments derived from the rice genes OsO3L2 and OsO3L3 could reduce Cd accumulation in transgenic rice. However, we did not test the full length genes due to prior work in Arabidopsis where overexpression of these genes caused seedling lethality. Here, we report on limiting the overexpression of OsO3L2 and OsO3L3 through the use of the stress- inducible promoter RD29B...
April 20, 2018: New Biotechnology
https://www.readbyqxmd.com/read/29684505/protective-effects-of-sulforaphane-on-cognitive-impairments-and-ad-like-lesions-in-diabetic-mice-are-associated-with-the-upregulation-of-nrf2-transcription-activity
#15
Die Pu, Yuxing Zhao, Jinliang Chen, Yue Sun, Ankang Lv, Shiyu Zhu, Cheng Luo, Kexiang Zhao, Qian Xiao
Type 2 diabetes mellitus (T2DM)-associated oxidative stress contributes to cognitive deficiencies and Alzheimer's disease (AD). Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions. This study investigated the effects of SFN on DM-related cognitive decline and its potential mechanisms. Morris water maze (MWM) tests showed that SFN (1 mg/kg i.p. for 28 days) mitigated the cognitive decline of db/db mice, a transgenic mouse model of T2DM...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29684396/jsh-23-prevents-depressive-like-behaviors-in-mice-subjected-to-chronic-mild-stress-effects-on-inflammation-and-antioxidant-defense-in-the-hippocampus
#16
Qi Wang, Xiaomei Dong, Nannan Li, Yan Wang, Xiaofeng Guan, Yiwei Lin, Jiguang Kang, Xia Zhang, Yuchen Zhang, Xiaobai Li, Tianchao Xu
Nuclear factor-kappa B (NF-κB), which is reported to play an important role in the pathogenesis of depression, also has a central role in the genesis and progression of inflammation. Here, we have targeted the nuclear translocation of NF-κB using 4-methyl-N1-(3-phenyl-propyl)-benzene-1,2-diamine (JSH-23) to elucidate its role in depression. We investigated the antidepressant-like effects of JSH-23 in the chronic mild stress (CMS) mouse model, which is a valid, reasonably reliable, and useful model of depression...
April 20, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29678455/different-behavioral-and-pathological-changes-between-epilepsy-associated-depression-and-primary-depression-models
#17
Wei-Feng Peng, Fan Fan, Xin Li, Qian-Qian Zhang, Jing Ding, Xin Wang
PURPOSE: Comorbid depression is common in patients with epilepsy. However, the epilepsy-associated depression is generally atypical and has not been fully recognized by neurologists. This study aimed to compare the behavioral and pathological changes between the chronic lithium chloride-pilocarpine rat epilepsy model (Licl-pilocarpine model) and the Chronic Unpredictable Mild Stress rat depression model (CUMS model), to evaluate for differences between epilepsy-associated depression and primary depression...
April 17, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29677563/polysaccharide-of-hericium-erinaceus-attenuates-colitis-in-c57bl-6-mice-via-regulation-of-oxidative-stress-inflammation-related-signaling-pathways-and-modulating-the-composition-of-the-gut-microbiota
#18
Yilin Ren, Yan Geng, Yan Du, Wang Li, Zhen-Ming Lu, Hong-Yu Xu, Guo-Hua Xu, Jin-Song Shi, Zheng-Hong Xu
Inflammatory bowel disease (IBD) is a disease caused by a dysregulated immune with unknown etiology. Hericium erinaceus (H. erinaceus) is a Chinese medicinal fungus, with the effect of prevention and treatment of gastrointestinal disorders. In this study, we have tested the anti-inflammatory effect of polysaccharide of H. erinaceus (HECP, Mw: 86.67 kDa) in the model of dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice. Our data indicated that HECP could improve clinical symptoms and down-regulate key markers of oxidative stresses, including nitric oxide (NO), malondialdehyde (MDA), total superoxide dismutase (T-SOD), and myeloperoxidase (MPO)...
March 16, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29674975/possible-role-of-nadph-oxidase-4-in-angiotensin-ii-induced-muscle-wasting-in-mice
#19
Tomoyasu Kadoguchi, Kazunori Shimada, Hiroshi Koide, Tetsuro Miyazaki, Tomoyuki Shiozawa, Shuhei Takahashi, Tatsuro Aikawa, Shohei Ouchi, Kenichi Kitamura, Yurina Sugita, Al Shahi Hamad, Mitsuhiro Kunimoto, Yayoi Sato-Okabayashi, Koji Akita, Kikuo Isoda, Hiroyuki Daida
Background: Muscle wasting is a debilitating phenotype associated with chronic heart failure (CHF). We have previously demonstrated that angiotensin II (AII) directly induces muscle wasting in mice through the activation of NADPH oxidase (Nox). In this study, we tested the hypothesis that deficiency of NADPH oxidase 4 (Nox4), a major source of oxidative stress, ameliorates AII-induced muscle wasting through the regulation of redox balance. Methods and Results: Nox4 knockout (KO) and wild-type (WT) mice were used...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29663102/docosahexaenoic-acid-dha-provides-neuroprotection-in-traumatic-brain-injury-models-via-activating-nrf2-are-signaling
#20
Wei Zhu, Yuexia Ding, Wei Kong, Tuo Li, Hongguang Chen
In this study, we explored the neuroprotective effects of docosahexaenoic acid (DHA) in traumatic brain injury (TBI) models. In this study, we first confirmed that DHA was neuroprotective against TBI via the NSS test and Morris water maze experiment. Western blot was conducted to identify the expression of Bax, caspase-3, and Bcl-2. And the cell apoptosis of the TBI models was validated by TUNEL staining. Relationships between nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) pathway-related genes and DHA were explored by RT-PCR and Western blot...
April 16, 2018: Inflammation
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