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https://www.readbyqxmd.com/read/29138827/gambogic-acid-inhibits-spinal-cord-injury-and-inflammation-through-suppressing-the-p38-and-akt-signaling-pathways
#1
Qiao Fu, Chaojian Li, Lehua Yu
Gamboge is the dry resin secreted by Garcinia hanburyi Hook.f, with the function of promoting blood circulation, detoxification, hemostasis and killing insects, used for the treatment of cancer, brain edema and other diseases. Gambogic acid is the main effective constituent of Gamboge. The present study investigated the protective effects of gambogic acid on spinal cord injury (SCI) and its anti‑inflammatory mechanism in an SCI model in vivo. Basso, Beattie and Bresnahan (BBB) testing was used to detect the protective effects of gambogic acid on nerve function of SCI rats...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29119268/gene-structure-expression-pattern-and-interaction-of-nuclear-factor-y-family-in-castor-bean-ricinus-communis
#2
Yue Wang, Wei Xu, Zexi Chen, Bing Han, Mohammad E Haque, Aizhong Liu
Nuclear Factor-Y transcription factors, which function in regulating seed development (including storage reservoir accumulation) and responding to abiotic stresses, were identified and characterized in castor bean. Nuclear Factor-Y (NF-Y) transcription factors in plants contain three subunits (NF-YA, NF-YB and NF-YC), and function as a heterodimer or heterotrimer complex in regulating plant growth, development and response to stresses. Castor bean (Ricinus communis, Euphorbiaceae) one of the most economically important non-edible oilseed crops, able to grow in diverse soil conditions and displays high tolerance to abiotic stresses...
November 8, 2017: Planta
https://www.readbyqxmd.com/read/29118329/aortic-stiffness-improves-the-prediction-of-both-diagnosis-and-severity-of-coronary-artery-disease
#3
Alexandra Yannoutsos, Mathieu Ahouah, Céline Dreyfuss Tubiana, Jirar Topouchian, Michel E Safar, Jacques Blacher
Elective coronography has low diagnostic yield for obstructive coronary artery disease (CAD). We aim to determine whether non-invasive aortic stiffness assessment improves diagnostic accuracy of CAD screening by reducing the number of false-positive results from the cardiac stress test. A cross-sectional study was conducted from January 2013 to September 2014 in our medical center. Electrocardiogram (ECG) stress test coupled with nuclear imaging was performed in 367 consecutive patients routinely followed for myocardial ischemia screening...
November 9, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29115830/gastrodin-and-isorhynchophylline-synergistically-inhibit-mpp-induced-oxidative-stress-in-sh-sy5y-cells-by-targeting-erk1-2-and-gsk-3%C3%AE-pathways-involvement-of-nrf2-nuclear-translocation
#4
Qiang Li, Chengu Niu, Xiaojie Zhang, Miaoxian Dong
Recently, the pathogenesis of Parkinson's disease (PD) is multifactorial event. Combination therapies might be more effective in controlling the disease. Thus, the studies reported were designed to test the hypothesis that gastrodin (GAS)-induced de novo synthesis of nuclear factor E2-related factor 2 (Nrf2) and isorhynchophylline (IRN) inhibition of Nrf2 nuclear export contribute to their additive or synergistic neuroprotective effect. Here, we have demonstrated that the combination of GAS and IRN (GAS/IRN) protect SH-SY5Y cells against 1-methyl-4-phenylpyridinium (MPP+) toxicity in a synergistic manner...
November 8, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29113806/cynatratoside-c-from-cynanchum-atratum-displays-anti-inflammatory-effect-via-suppressing-tlr4-mediated-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways-in-lps-induced-mastitis-in-mice
#5
Ge Hu, Dong Hong, Tao Zhang, Huiqin Duan, Panying Wei, Xinxin Guo, Xiang Mu
The present study was conducted to isolate anti-inflammatory compound from Cynanchum atratum and investigate the molecular mechanisms of active compound against lipopolysaccharide (LPS)-induced mastitis in mice. Bioassay-guided fractionations and isolation (via ex vivo tests) of compounds with anti-inflammatory activity were performed on roots of C. atratum yielding a pure bioactive compound: Cynatratoside-C, identified by comparing spectral data (EI-MS, (1)H NMR and (13)C NMR) with literature values. Ex vivo tests showed that Cynatratoside-C inhibited the expression of TLR4 and pro-inflammatory cytokine (TNF-α, IL-6 and IL-1β) production in LPS-stimulated primary mouse mammary epithelial cells...
November 4, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29110132/novel-mesenchymal-stem-cell-strategy-in-alleviating-toll-like-receptor-4-p53-and-nrf2-signaling-in-isoproterenol-induced-myocardial-infarction-in-rat-model
#6
Mai O Kadry, Rehab M Abdel-Megeed
Mesenchymal stem cells (MSCs) are multipotent stromal cells that merit the differentiation into various cell types. The present study was designed to test the hypothesis that the cardioprotective effect of MSCs transplantation and digoxin treatment is mediated via the regulation of messenger RNA gene expression of pro-inflammatory cytokines and apoptotic markers. Myocardial infarction was induced in Wistar rats via isoproterenol injection in a dose of (85 mg/kg, subcutaneously, twice at an interval of 24 h)...
November 6, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29098059/curcumin-reverses-the-diazepam-induced-cognitive-impairment-by-modulation-of-oxidative-stress-and-erk-1-2-nf-%C3%AE%C2%BAb-pathway-in-brain
#7
Alexandra C Sevastre-Berghian, Vlad Făgărăsan, Vlad A Toma, Ioana Bâldea, Diana Olteanu, Remus Moldovan, Nicoleta Decea, Gabriela A Filip, Simona V Clichici
Oxidative stress and inflammation can be involved in cognitive dysfunction associated with neurodegenerative disorders. Diazepam (DZP) administration has been chosen to simulate the memory impairment. The aim of this study was to evaluate the effects of curcumin (CUR) on spatial cognition, ambulatory activity, and blood and brain oxidative stress levels. The ERK/NF-κB signaling pathway and the histopathological changes in the hippocampus and frontal lobe, in diazepam-treated rats, were also analyzed. The animals were divided into 4 groups: control, carboxymethylcellulose (CMC) + CUR, CMC + DZP, and CUR + CMC + DZP...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29091894/zinc-alogliptin-combination-attenuates-testicular-toxicity-induced-by-doxorubicin-in-rats-role-of-oxidative-stress-apoptosis-and-tgf-%C3%AE-1-nf-%C3%AE%C2%BAb-signaling
#8
Ahmed M Kabel
The aim of this study was to assess the effect of alogliptin and/or zinc on doxorubicin (DOX)-induced testicular toxicity in rats. Sixty male Wistar rats were divided into 6 equal groups: Control; DOX; DOX+Zinc; DOX+Alogliptin; DOX+Carboxymethyl cellulose and DOX+Zinc+Alogliptin. Testis weight, testicular functions, serum testosterone, luteinizing hormone, follicle stimulating hormone and zinc were measured. Also, testicular tissue zinc, 3 β-hydroxysteroid dehydrogenase, 17 β- hydroxysteroid dehydrogenase, antioxidant enzymes, pro-inflammatory cytokines, transforming growth factor beta 1 (TGF-β1), nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and sperm characteristics were assessed...
October 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29065547/phenolic-compounds-present-schinus-terebinthifolius-raddi-influence-the-lowering-of-blood-pressure-in-rats
#9
Lorena de Lima Glória, Mariana Barreto de Souza Arantes, Silvia Menezes de Faria Pereira, Guilherme de Souza Vieira, Camilla Xavier Martins, Almir Ribeiro de Carvalho Junior, Fernanda Antunes, Raimundo Braz-Filho, Ivo José Curcino Vieira, Larissa Leandro da Cruz, Douglas Siqueira de Almeida Chaves, Silvério de Paiva Freitas, Daniela Barros de Oliveira
This study identified two phenolic compounds in Schinus terebinthifolius Raddi fruits: naringenin (first report in this species) and gallic acid. Their structures were elucidated by nuclear magnetic resonance (NMR) data (¹H-, (13)C-NMR) and a high-performance liquid chromatography (HPLC) technique. A high content of phenolics (659.21 mg of gallic acid equivalents/g of sample-Folin-Ciocalteau method) and total flavonoids (140.69 mg of rutin equivalents/g of sample-aluminum chloride method) were quantified in S...
October 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29053994/dietary-resveratrol-confers-apoptotic-resistance-to-oxidative-stress-in-myoblasts
#10
Satoshi Haramizu, Shinichi Asano, David C Butler, David A Stanton, Ameena Hajira, Junaith S Mohamed, Stephen E Alway
High levels of reactive oxygen species (ROS) contribute to muscle cell death in aging and disuse. We have previously found that resveratrol can reduce oxidative stress in response to aging and hindlimb unloading in rodents in vivo, but it was not known if resveratrol would protect muscle stem cells during repair or regeneration when oxidative stress is high. To test the protective role of resveratrol on muscle stem cells directly, we treated the C2C12 mouse myoblast cell line with moderate (100 μM) or very high (1 mM) levels of H2O2 in the presence or absence of resveratrol...
August 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29030784/anti-tnf-%C3%AE-antibody-alleviates-insulin-resistance-in-rats-with-sepsis-induced-stress-hyperglycemia
#11
W Qu, C Han, M Li, J Zhang, Z Jiang
PURPOSE: To explore the effects and mechanisms of anti-tumor necrosis factor-α (TNF-α) antibody on insulin resistance (IR) in rats with sepsis-induced stress hyperglycemia. METHODS: The sepsis-induced stress hyperglycemic rat model was constructed by cecal ligation and puncture combined with the intraperitoneal injection of lipopolysaccharide. The rats were randomly divided into six groups: normal control (NC) group, surgical rats (Cntl) group, high-dose anti-TNF-α antibody therapy (TNF, 6 mg/kg) group, low-dose anti-TNF-α antibody therapy (Tnf, 3 mg/kg) group, insulin therapy (INS) group, and INS + Tnf group...
October 13, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29024717/supplementation-of-american-ginseng-berry-extract-mitigated-cisplatin-evoked-nephrotoxicity-by-suppressing-ros-mediated-activation-of-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#12
Zhi-Na Ma, Zhi Liu, Zi Wang, Shen Ren, Shan Tang, Ying-Ping Wang, Sheng-Yuan Xiao, Chen Chen, Wei Li
Nephrotoxicity induced by cisplatin in 30% of all cisplatin treated patients seriously limits its clinical implication as a widely used anticancer agent, and may even cause patients to alter or give up cisplatin therapy. The purpose of this study is to test a protective effect of American ginseng berry extract (AGBE) on cisplatin-induced nephrotoxicity in mice. In this study, the histopathological changes and elevated levels of serum creatinine (CRE) and urea nitrogen (BUN) caused by cisplatin were significantly diminished by AGBE treatment...
October 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29018242/nuclear-factor-erythroid-derived-2-like-2-activation-increases-exercise-endurance-capacity-via-redox-modulation-in-skeletal-muscles
#13
Sechang Oh, Shoichi Komine, Eiji Warabi, Kentaro Akiyama, Akiko Ishii, Kazunori Ishige, Yuji Mizokami, Keisuke Kuga, Masaki Horie, Yoshihiro Miwa, Takao Iwawaki, Masayuki Yamamoto, Junichi Shoda
Sulforaphane (SFN) plays an important role in preventing oxidative stress by activating the nuclear factor (erythroid derived 2)-like 2 (Nrf2) signalling pathway. SFN may improve exercise endurance capacity by counteracting oxidative stress-induced damage during exercise. We assessed running ability based on an exhaustive treadmill test (progressive-continuous all-out) and examined the expression of markers for oxidative stress and muscle damage. Twelve- to 13-week-old Male wild-type mice (Nrf2 (+/+)) and Nrf2-null mice (Nrf2 (-/-)) on C57BL/6J background were intraperitoneally injected with SFN or vehicle prior to the test...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29016795/leonurine-exerts-antidepressant-like-effects-in-the-chronic-mild-stress-induced-depression-model-in-mice-by-inhibiting-neuroinflammation
#14
Miaomiao Jia, Chenxin Li, Ying Zheng, Xiaojing Ding, Meng Chen, Jianhua Ding, Renhong Du, Ming Lu, Gang Hu
Background: Leonurine is an active alkaloid that is extracted from Traditional Chinese Medicine Herba leonuri. Emerging evidence indicates that leonurine produces neuroprotective effects in ischemic stroke, Parkinson's disease, and Alzheimer's disease. However, the effect of leonurine in neuropsychiatric disorders, especially in major depression, remains unknown. Methods: We used the chronic mild stress mouse model to explore the antidepressant effects of leonurine and the potential mechanisms...
November 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29016792/antidepressant-like-actions-of-inhibitors-of-poly-adp-ribose-polymerase-in-rodent-models
#15
Gregory A Ordway, Attila Szebeni, Liza J Hernandez, Jessica D Crawford, Katalin Szebeni, Michelle J Chandley, Katherine C Burgess, Corwin Miller, Erol Bakkalbasi, Russell W Brown
Background: Many patients suffering from depressive disorders are refractory to treatment with currently available antidepressant medications, while many more exhibit only a partial response. These factors drive research to discover new pharmacological approaches to treat depression. Numerous studies demonstrate evidence of inflammation and elevated oxidative stress in major depression. Recently, major depression has been shown to be associated with elevated levels of DNA oxidation in brain cells, accompanied by increased gene expression of the nuclear base excision repair enzyme, poly(ADP-ribose) polymerase-1...
August 3, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28992620/potential-ameliorative-effects-of-qing-ye-dan-against-cadmium-induced-prostatic-deficits-via-regulating-nrf-2-ho-1-and-tgf-%C3%AE-1-smad-pathways
#16
Lifen Du, Yongfang Lei, Jinglou Chen, Hongping Song, Xinying Wu
BACKGROUND/AIMS: Cadmium (Cd) is an environmental pollutant with reproductive toxicity. Swertia mileensis is used in Chinese medicine for the treatment of prostatic deficits and named as Qing Ye Dan (QYD). This study was undertaken to investigate the potential protective effects of QYD against Cd-induced prostatic deficits. METHOD: Rat model of prostatic deficits was induced by 0.2 mg/kg/d CdCl2 subcutaneous injection for 15 days. The prostatic oxidative stress was evaluated by detecting the levels of malondialdehyde, nitric oxide, reduced/ oxidized glutathione, total sulfhydryl groups and enzymatic antioxidant status...
October 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28989083/resveratrol-activation-of-ampk-dependent-pathways-is-neuroprotective-in-human-neural-stem-cells-against-amyloid-beta-induced-inflammation-and-oxidative-stress
#17
Ming-Chang Chiang, Christopher J Nicol, Yi-Chuan Cheng
Alzheimer's disease (AD) is a neurodegenerative disorder with progressive memory loss resulting in dementia. Amyloid-beta (Aβ) peptides play a critical role in the pathogenesis of this disease, and are thought to promote inflammation and oxidative stress leading to neurodegeneration in the neocortex and hippocampus of the AD brains. AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis, and cell survival in response to inflammation and oxidative stress. However, the neuroprotective mechanisms by which AMPK achieves these beneficial effects in human neural stem cells (hNSCs) exposed to Aβ is still not well understood...
October 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28977522/psychogenic-stress-activates-c-fos-in-nucleus-accumbens-projecting-neurons-of-the-hippocampal-ventral-subiculum
#18
Witold J Lipski, Sofia M Dibble, Linda Rinaman, Anthony A Grace
Background: The ventral subiculum is known to be activated by the presentation of novel stressors. It has been hypothesized that neuronal ensembles at the ventral aspect of the hippocampal formation are involved in context-dependent processing and can guide the learning of appropriate action selections in response to threatening contexts. Artificial activation of the ventral subiculum can excite medium spiny neurons of the nucleus accumbens and can increase the excitability of mesolimbic dopamine neurons via a polysynaptic pathway through the basal ganglia...
October 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28974356/long-term-photoreceptor-rescue-in-two-rodent-models-of-retinitis-pigmentosa-by-adeno-associated-virus-delivery-of-stanniocalcin-1
#19
Gavin W Roddy, Douglas Yasumura, Michael T Matthes, Marcel V Alavi, Sanford L Boye, Robert H Rosa, Michael P Fautsch, William W Hauswirth, Matthew M LaVail
Retinal degenerations, including age-related macular degeneration and the retinitis pigmentosa family of diseases, are among the leading causes of legal blindness in the United States. We previously found that Stanniocalcin-1 (STC-1) reduced photoreceptor loss in the S334ter-3 and Royal College of Surgeons rat models of retinal degeneration. The results were attributed in part to a reduction in oxidative stress. Herein, we tested the hypothesis that long-term delivery of STC-1 would provide therapeutic rescue in more chronic models of retinal degeneration...
September 30, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28965254/lipid-metabolism-is-closely-associated-with-normal-testicular-growth-based-on-global-transcriptome-profiles-in-normal-and-underdeveloped-testis-of-obese-zucker-fa-fa-rats
#20
Jutika Datar, Alemu Regassa, Woo-Kyun Kim, Carla G Taylor, Peter Zahradka, Miyoung Suh
Zucker (fa/fa) obese rats often have non-identical and differently sized paired testes, leaving one testis underdeveloped. Our earlier study found that the underdeveloped testes, > 30% smaller than the normal ones, have a selective decrease in docosapentaenoic acid (22:5n-6), a dominant fatty acid in the testes. This study was conducted to examine global testicular transcriptome profile in underdeveloped testes relative to developed ones using Rat Gene 2.0 ST Array (Affymetrix, USA). Testes were obtained from 14-week-old, sexually mature male obese (fa/fa) Zucker rats...
November 2017: Lipids
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